hydroquinone has been researched along with Ochronosis in 43 studies
Ochronosis: The yellowish discoloration of connective tissue due to deposition of HOMOGENTISIC ACID (a brown-black pigment). This is due to defects in the metabolism of PHENYLALANINE and TYROSINE. Ochronosis occurs in ALKAPTONURIA, but has also been associated with exposure to certain chemicals (e.g., PHENOL, trinitrophenol, BENZENE DERIVATIVES).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Three cases of suspected hydroquinone-induced exogenous ochronosis while treating melasma were subjected to dermatoscopy and histopathology studies." | 7.79 | Diagnostic utility of dermatoscopy in hydroquinone-induced exogenous ochronosis. ( Deshpande, DJ; Dhurat, RS; Mishra, SN; Nayak, CS, 2013) |
| "Two patients with exogenous ochronosis, an unfamiliar side effect of hydroquinone-containing bleaching creams, are presented." | 7.68 | [Exogenous ochronosis, a little-known side effect of hydroquinone-containing ointments]. ( Dekker, SK; Menke, HE; Noordhoek Hegt, V; Pavel, S; Westerhof, W, 1992) |
| "Exogenous localized ochronosis can result from the repeated use of hydroquinone-containing creams, many of which are available over the counter." | 7.68 | Hydroquinone-induced localized exogenous ochronosis treated with dermabrasion and CO2 laser. ( Diven, DG; Lee, M; Pupo, RA; Smith, EB, 1990) |
| "Hyperpigmentation is the most common complaint in the age group 40-45 years, seeking consultation for skin disorders." | 6.82 | Hyperpigmentation: Looking beyond hydroquinone. ( Charoo, NA, 2022) |
| " The principal adverse effects of its chronic use are confetti-like depigmentation and exogenous ochronosis." | 5.35 | Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy. ( Azulay-Abulafia, L; Barcaui, CB; Charlín, R; Kac, BK; Rabello-Fonseca, R; Soares, DB, 2008) |
| "Recently, the US Food and Drug Administration proposed a ban on over-the-counter hydroquinone mainly on the basis of high absorption, reports of exogenous ochronosis in humans, and murine hepatic adenomas, renal adenomas, and leukemia with large doses over extended time periods." | 4.84 | The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register. ( Levitt, J, 2007) |
| "Exogenous ochronosis (EO) is a deposition disease associated with application of hydroquinone-containing preparations." | 3.96 | Exogenous Ochronosis as an Elastotic Disease: A Light-Microscopic Approach. ( Goldberg, LJ; Ho, JD; Vashi, N, 2020) |
| " All 3 had been using skin-lightening lotions containing hydroquinone on their faces for between 3 and 15 years and had black-blue facial pigmentation of exogenous ochronosis, a recognized complication of these creams." | 3.91 | Corneal and Scleral Problems Caused by Skin-Lightening Creams. ( Angunawela, RI; Gore, DM; Hollick, EJ; Igwe, C; Jones, SM; Papamichael, E; Philippidou, M, 2019) |
| "We present a case of exogenous ochronosis in a 53-year-old woman with skin type IV, who used a topical hydroquinone preparation of an unknown concentration for several years." | 3.80 | Exogenous ochronosis. ( Hale, CS; Leger, M; Meehan, SA; Nagler, A, 2014) |
| "Exogenous ochronosis (EO), a disfiguring cutaneous complication of topical hydroquinone use, is difficult to treat." | 3.79 | Exogenous ochronosis - successful outcome after treatment with Q-switched Nd:YAG laser. ( Tan, SK, 2013) |
| " Three cases of suspected hydroquinone-induced exogenous ochronosis while treating melasma were subjected to dermatoscopy and histopathology studies." | 3.79 | Diagnostic utility of dermatoscopy in hydroquinone-induced exogenous ochronosis. ( Deshpande, DJ; Dhurat, RS; Mishra, SN; Nayak, CS, 2013) |
| "Exogenous (cosmetic) ochronosis is caused by the long term use of skin-lightening creams containing hydroquinone." | 3.76 | Cutaneous annular sarcoidosis developing on a background of exogenous ochronosis: a report of two cases and review of the literature. ( Glassman, SJ; Grayson, W; Moche, MJ; Modi, D, 2010) |
| "We describe a 63-year-old Hispanic woman who developed exogenous ochronosis lesions on her face after using topical bleaching creams containing hydroquinone, 2% to 3%, and oxybenzone, 2%, for several years." | 3.76 | Dermoscopic and reflectance confocal microscopic features of exogenous ochronosis. ( Gil, I; Herrero-González, JE; Lloreta, J; Martínez-Escala, E; Puig, S; Pujol, RM; Segura, S; Vélez, M, 2010) |
| "A 55-year-old woman with melasma develops biopsy-proved exogenous ochronosis in the setting of prolonged topical hydroquinone use." | 3.74 | Exogenous ochronosis. ( Brown, L; Meehan, S; Merola, JF; Walters, RF, 2008) |
| "Exogenous ochronosis is a paradoxical hyper-pigmentation of the skin caused by the long-term use of hydroquinone-containing bleaching creams." | 3.73 | Exogenous ochronosis and striae atrophicae following the use of bleaching creams. ( Aricò, M; Bongiorno, MR, 2005) |
| "Exogenous ochronosis is a cutaneous disorder characterized by blue-black or slate-gray hyperpigmentation resulting from the prolonged use of certain topical agents, most commonly hydroquinones." | 3.72 | Treatment of exogenous ochronosis with a Q-switched alexandrite (755 nm) laser. ( Alster, TS; Bellew, SG, 2004) |
| " We also note the incidental histologic finding of exogenous ochronosis, which, in our case, indicates the patient's use of hydroquinone-containing bleaching creams in an attempt to treat the disorder." | 3.71 | Primary multiple miliary osteoma cutis and exogenous ochronosis. ( Bowman, PH; Lesher, JL, 2001) |
| "Two patients with exogenous ochronosis, an unfamiliar side effect of hydroquinone-containing bleaching creams, are presented." | 3.68 | [Exogenous ochronosis, a little-known side effect of hydroquinone-containing ointments]. ( Dekker, SK; Menke, HE; Noordhoek Hegt, V; Pavel, S; Westerhof, W, 1992) |
| "Exogenous ochronosis is caused by the long-term application of skin-lightening creams containing hydroquinone." | 3.68 | Transepidermal elimination in exogenous ochronosis. A report of two cases. ( Jordaan, HF; Van Niekerk, DJ, 1991) |
| " Fifty-four patients had photodermatoses from exogenous causes, of which hydroquinone-induced exogenous ochronosis constituted the largest group of patients." | 3.67 | Photodermatoses in Lagos. ( Olumide, YM, 1987) |
| "Hyperpigmentation is the most common complaint in the age group 40-45 years, seeking consultation for skin disorders." | 2.82 | Hyperpigmentation: Looking beyond hydroquinone. ( Charoo, NA, 2022) |
| "Hydroquinone has pharmacological uses in disorders of pigmentation because of its ability to competitively inhibit the enzyme tyrosinase." | 2.72 | Hydroquinone: myths and reality. ( Al-Niaimi, F; Ali, FR; Searle, T, 2021) |
| "Exogenous ochronosis is clinically and histologically similar to its endogenous counterpart; however, it exhibits no systemic effects and is not an inherited disorder." | 2.41 | Exogenous ochronosis. An update on clinical features, causative agents and treatment options. ( Levin, CY; Maibach, H, 2001) |
| " The principal adverse effects of its chronic use are confetti-like depigmentation and exogenous ochronosis." | 1.35 | Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy. ( Azulay-Abulafia, L; Barcaui, CB; Charlín, R; Kac, BK; Rabello-Fonseca, R; Soares, DB, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (9.30) | 18.7374 |
| 1990's | 7 (16.28) | 18.2507 |
| 2000's | 12 (27.91) | 29.6817 |
| 2010's | 15 (34.88) | 24.3611 |
| 2020's | 5 (11.63) | 2.80 |
| Authors | Studies |
|---|---|
| Charoo, NA | 1 |
| Ma, Y | 1 |
| Millette, D | 1 |
| Nalluri, R | 1 |
| Yoo, J | 1 |
| Ho, JD | 1 |
| Vashi, N | 1 |
| Goldberg, LJ | 1 |
| Roche, L | 1 |
| White, J | 1 |
| Bourke, J | 1 |
| Searle, T | 1 |
| Al-Niaimi, F | 1 |
| Ali, FR | 1 |
| Pirrone, J | 1 |
| Broyer, J | 1 |
| Otte, N | 1 |
| Reich, K | 1 |
| Boer-Auer, A | 1 |
| Sánchez-Martínez, EM | 1 |
| García-Briz, MI | 1 |
| Moneva-Léniz, LM | 1 |
| Gegúndez-Hernández, H | 1 |
| Pose-Lapausa, P | 1 |
| Mateu-Puchades, A | 1 |
| Hollick, EJ | 1 |
| Igwe, C | 1 |
| Papamichael, E | 1 |
| Gore, DM | 1 |
| Angunawela, RI | 1 |
| Philippidou, M | 1 |
| Jones, SM | 1 |
| Tan, SK | 2 |
| Liu, WC | 1 |
| Tey, HL | 1 |
| Lee, JS | 1 |
| Goh, BK | 1 |
| Kindem, S | 1 |
| Serra-Guillén, C | 1 |
| Guillén, C | 1 |
| Nagler, A | 1 |
| Hale, CS | 1 |
| Meehan, SA | 1 |
| Leger, M | 1 |
| Simmons, BJ | 1 |
| Griffith, RD | 1 |
| Bray, FN | 1 |
| Falto-Aizpurua, LA | 1 |
| Nouri, K | 1 |
| Ndoye Roth, PA | 1 |
| Ly, F | 1 |
| Kane, H | 1 |
| Bissang, AA | 1 |
| Wane, AM | 1 |
| Sow, AS | 1 |
| Ndiaye, JM | 1 |
| Nguer, M | 1 |
| Ba, EA | 1 |
| Ndiaye, MR | 1 |
| Cinotti, E | 1 |
| Labeille, B | 1 |
| Douchet, C | 1 |
| Cambazard, F | 1 |
| Perrot, JL | 1 |
| Córdova, ME | 1 |
| Pérez-Rojas, DO | 1 |
| López-Marquet, AD | 1 |
| Arenas, R | 1 |
| Merola, JF | 1 |
| Meehan, S | 1 |
| Walters, RF | 1 |
| Brown, L | 1 |
| Moche, MJ | 1 |
| Glassman, SJ | 1 |
| Modi, D | 1 |
| Grayson, W | 1 |
| Zawar, V | 1 |
| Chuh, A | 1 |
| Gil, I | 1 |
| Segura, S | 1 |
| Martínez-Escala, E | 1 |
| Lloreta, J | 1 |
| Puig, S | 1 |
| Vélez, M | 1 |
| Pujol, RM | 1 |
| Herrero-González, JE | 1 |
| Mishra, SN | 1 |
| Dhurat, RS | 1 |
| Deshpande, DJ | 1 |
| Nayak, CS | 1 |
| Bellew, SG | 1 |
| Alster, TS | 1 |
| Kooyers, TJ | 1 |
| Westerhof, W | 2 |
| Bongiorno, MR | 1 |
| Aricò, M | 1 |
| Huerta Brogeras, M | 1 |
| Sánchez-Viera, M | 1 |
| Palm, MD | 1 |
| Toombs, EL | 1 |
| Levitt, J | 1 |
| Charlín, R | 1 |
| Barcaui, CB | 1 |
| Kac, BK | 1 |
| Soares, DB | 1 |
| Rabello-Fonseca, R | 1 |
| Azulay-Abulafia, L | 1 |
| Olumide, YM | 2 |
| Akinkugbe, AO | 1 |
| Altraide, D | 1 |
| Mohammed, T | 1 |
| Ahamefule, N | 1 |
| Ayanlowo, S | 1 |
| Onyekonwu, C | 1 |
| Essen, N | 1 |
| Sim, CS | 1 |
| Goh, CL | 1 |
| Jacyk, WK | 1 |
| Camarasa, JG | 1 |
| Serra-Baldrich, E | 1 |
| Snider, RL | 1 |
| Thiers, BH | 1 |
| Fisher, AA | 1 |
| Bowman, PH | 1 |
| Lesher, JL | 1 |
| Levin, CY | 1 |
| Maibach, H | 1 |
| Menke, HE | 1 |
| Dekker, SK | 1 |
| Noordhoek Hegt, V | 1 |
| Pavel, S | 1 |
| Jordaan, HF | 1 |
| Van Niekerk, DJ | 1 |
| Diven, DG | 1 |
| Smith, EB | 1 |
| Pupo, RA | 1 |
| Lee, M | 1 |
| Lawrence, N | 1 |
| Bligard, CA | 1 |
| Reed, R | 1 |
| Perret, WJ | 1 |
| Tidman, MJ | 1 |
| Horton, JJ | 1 |
| MacDonald, DM | 1 |
| Hoshaw, RA | 1 |
| Zimmerman, KG | 1 |
| Menter, A | 1 |
8 reviews available for hydroquinone and Ochronosis
| Article | Year |
|---|---|
Hyperpigmentation: Looking beyond hydroquinone.
Topics: Adult; Humans; Hydroquinones; Hyperpigmentation; Middle Aged; Ochronosis | 2022 |
Hydroquinone: myths and reality.
Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Drug Therapy, Combination; Humans; Hydroquinones | 2021 |
Exogenous ochronosis: a comprehensive review of the diagnosis, epidemiology, causes, and treatments.
Topics: Dermatologic Agents; Dermoscopy; Humans; Hydroquinones; Ochronosis; Skin Pigmentation | 2015 |
[Toxicological aspects and health risks associated with hydroquinone in skin bleaching formula].
Topics: Administration, Topical; Cosmetics; Dose-Response Relationship, Drug; Face; Humans; Hydroquinones; H | 2004 |
The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register.
Topics: Absorption; Adenoma; Animals; Carcinogenicity Tests; Drug Approval; Fertility; Humans; Hydroquinones | 2007 |
Complications of chronic use of skin lightening cosmetics.
Topics: Black People; Cosmetics; Cushing Syndrome; Dermatologic Agents; Female; Glucocorticoids; Humans; Hyd | 2008 |
Hydroquinone-induced exogenous ochronosis in Chinese--two case reports and a review.
Topics: Administration, Cutaneous; Asian People; Dermatologic Agents; Female; Humans; Hydroquinones; Melanos | 2008 |
Exogenous ochronosis. An update on clinical features, causative agents and treatment options.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Bacterial Agents; Caustics; Cosmetics; Cryotherapy; Derma | 2001 |
35 other studies available for hydroquinone and Ochronosis
| Article | Year |
|---|---|
UK-based dermatologist online survey on the current practice and training in the management of melasma and postinflammatory hyperpigmentation.
Topics: Administration, Topical; Alkaptonuria; Dermatologists; Drug Therapy, Combination; Humans; Hydroquino | 2020 |
Exogenous Ochronosis as an Elastotic Disease: A Light-Microscopic Approach.
Topics: Elastic Tissue; Humans; Hydroquinones; Ochronosis; Retrospective Studies | 2020 |
Black symmetrical papular eruption of the zygomata.
Topics: Administration, Topical; Alkaptonuria; Biopsy; Exanthema; Humans; Hydroquinones; Male; Middle Aged; | 2020 |
Extensive hyperpigmentation of the face in a Filipina.
Topics: Administration, Topical; Diagnosis, Differential; Facial Dermatoses; Female; Hispanic or Latino; Hum | 2017 |
Exogenous ochronosis: the failure of depigmenting creams.
Topics: Antioxidants; Back; Facial Dermatoses; Female; Humans; Hydroquinones; Hyperpigmentation; Middle Aged | 2019 |
Corneal and Scleral Problems Caused by Skin-Lightening Creams.
Topics: Administration, Topical; Aged; Alkaptonuria; Biopsy; Cornea; Dermatologic Agents; Female; Humans; Hy | 2019 |
Exogenous ochronosis - successful outcome after treatment with Q-switched Nd:YAG laser.
Topics: Adult; Aged; Asian People; Facial Dermatoses; Female; Humans; Hydroquinones; Hyperpigmentation; Lase | 2013 |
Exogenous ochronosis in a Chinese patient: use of dermoscopy aids early diagnosis and selection of biopsy site.
Topics: Alkaptonuria; Biopsy; Bleaching Agents; China; Dermoscopy; Humans; Hydroquinones; Male; Melanosis; M | 2014 |
Patchy facial hyperpigmentation.
Topics: Facial Dermatoses; Female; Humans; Hydroquinones; Middle Aged; Ochronosis; Skin Lightening Preparati | 2015 |
Exogenous ochronosis.
Topics: Antioxidants; Facial Dermatoses; Female; Humans; Hydroquinones; Middle Aged; Ochronosis | 2014 |
[Ocular lesions of artificial depigmentation].
Topics: Adrenal Cortex Hormones; Adult; Age Factors; Case-Control Studies; Cataract; Eye Diseases; Eyelid Di | 2015 |
[Role of dermoscopy and reflectance confocal microscopy as an aid in the diagnosis of exogenous ochronosis].
Topics: Adult; Biopsy; Dermoscopy; Facial Dermatoses; Female; Humans; Hydroquinones; Macrophages; Melanins; | 2016 |
Exogenous Ochronosis in Facial Melasma.
Topics: Dermoscopy; Facial Dermatoses; Female; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Hyd | 2017 |
Exogenous ochronosis.
Topics: Dermatologic Agents; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Hydroquinones; Mela | 2008 |
Cutaneous annular sarcoidosis developing on a background of exogenous ochronosis: a report of two cases and review of the literature.
Topics: Cosmetics; Drug Eruptions; Female; Humans; Hydroquinones; Middle Aged; Ochronosis; Sarcoidosis; Skin | 2010 |
Exogenous ochronosis in Asians.
Topics: Antioxidants; Asian People; Humans; Hydroquinones; Melanosis; Ochronosis; Pigmentation Disorders | 2010 |
Dermoscopic and reflectance confocal microscopic features of exogenous ochronosis.
Topics: Benzophenones; Biopsy, Needle; Cosmetics; Dermoscopy; Facial Dermatoses; Female; Follow-Up Studies; | 2010 |
Diagnostic utility of dermatoscopy in hydroquinone-induced exogenous ochronosis.
Topics: Adult; Dermoscopy; Humans; Hydroquinones; Male; Melanosis; Ochronosis | 2013 |
Treatment of exogenous ochronosis with a Q-switched alexandrite (755 nm) laser.
Topics: Beryllium; Dermatologic Agents; Face; Female; Humans; Hydroquinones; Hyperpigmentation; Laser Therap | 2004 |
Exogenous ochronosis and striae atrophicae following the use of bleaching creams.
Topics: Atrophy; Dermatologic Agents; Female; Glucocorticoids; Humans; Hydroquinones; Hyperpigmentation; Mid | 2005 |
Exogenous ochronosis.
Topics: Aged; Female; Humans; Hydroquinones; Ochronosis | 2006 |
Hydroquinone and the FDA--the debate?
Topics: Africa; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Humans; Hydroquinones; Ochro | 2007 |
Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy.
Topics: Administration, Cutaneous; Adult; Dermatologic Agents; Dermoscopy; Female; Humans; Hydroquinones; Hy | 2008 |
Annular granulomatous lesions in exogenous ochronosis are manifestation of sarcoidosis.
Topics: Adult; Aged; Collagen; Diagnosis, Differential; Elastic Tissue; Eosinophils; Facial Dermatoses; Fema | 1995 |
Exogenous ochronosis with allergic contact dermatitis from hydroquinone.
Topics: Dermatitis, Allergic Contact; Drug Eruptions; Facial Dermatoses; Female; Humans; Hydroquinones; Midd | 1994 |
Exogenous ochronosis.
Topics: Administration, Cutaneous; Dermatologic Agents; Facial Dermatoses; Female; Humans; Hydroquinones; Mi | 1993 |
Exogenous ochronosis from hydroquinone bleaching cream.
Topics: Cosmetics; Female; Humans; Hydroquinones; Ochronosis; Ointments | 1998 |
Primary multiple miliary osteoma cutis and exogenous ochronosis.
Topics: Aged; Biopsy, Needle; Facial Neoplasms; Female; Humans; Hydroquinones; Immunohistochemistry; Ochrono | 2001 |
[Exogenous ochronosis, a little-known side effect of hydroquinone-containing ointments].
Topics: Adult; Female; Humans; Hydroquinones; Middle Aged; Ochronosis; Ointments; Pigmentation Disorders; Sk | 1992 |
Transepidermal elimination in exogenous ochronosis. A report of two cases.
Topics: Adult; Black People; Cosmetics; Female; Humans; Hydroquinones; Male; Middle Aged; Ochronosis; Skin | 1991 |
Hydroquinone-induced localized exogenous ochronosis treated with dermabrasion and CO2 laser.
Topics: Dermabrasion; Female; Humans; Hydroquinones; Laser Therapy; Middle Aged; Ochronosis | 1990 |
Photodermatoses in Lagos.
Topics: Black People; Female; Histamine H1 Antagonists; Humans; Hydroquinones; Male; Middle Aged; Nigeria; O | 1987 |
Exogenous ochronosis in the United States.
Topics: Adult; Female; Humans; Hydroquinones; Male; Middle Aged; Ochronosis; Phenol; Phenols; Resorcinols; S | 1988 |
Hydroquinone-induced ochronosis--light and electronmicroscopic features.
Topics: Female; Humans; Hydroquinones; Middle Aged; Ochronosis; Skin | 1986 |
Ochronosislike pigmentation from hydroquinone bleaching creams in American blacks.
Topics: Aged; Black or African American; Cosmetics; Female; Humans; Hydroquinones; Middle Aged; Ochronosis; | 1985 |