hydroquinone has been researched along with Leukemia in 14 studies
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous studies indicated that the benzene metabolite hydroquinone (HQ) evokes the ROS/p38 MAPK/protein phosphatase 2A/tristetraprolin axis, leading to increased TNF-α expression in human acute myeloid leukemia cell lines U937 and HL-60." | 8.31 | Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells. ( Chang, LS; Chen, YJ; Chiou, JT; Lee, YC; Wang, LJ, 2023) |
| "Hydroquinone (HQ) is an important benzene-derived metabolite associated with acute myelogenous leukemia risk." | 7.83 | Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells. ( Bollati, V; Conti, A; Dieci, G; Favero, C; Fustinoni, S; Lazzari, L; Motta, V; Ragni, E; Rota, F, 2016) |
| "Studies on HQ-treated human leukemia K562 (Bcr/Abl-positive) cells were conducted to address the hydroquinone (HQ) mechanism that promotes soluble TNF-α (sTNF-α) production." | 7.79 | Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl. ( Chang, LS; Chen, YJ, 2013) |
| "Recently, the US Food and Drug Administration proposed a ban on over-the-counter hydroquinone mainly on the basis of high absorption, reports of exogenous ochronosis in humans, and murine hepatic adenomas, renal adenomas, and leukemia with large doses over extended time periods." | 4.84 | The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register. ( Levitt, J, 2007) |
| "Hydroquinone (HQ) produced renal adenomas in male F344 rats, and these tumors appeared to arise from areas of spontaneous progressive nephropathy; the nephropathy itself has been found to be enhanced by HQ." | 4.79 | Analysis of studies related to tumorigenicity induced by hydroquinone. ( English, JC; Verna, L; Whysner, J; Williams, GM, 1995) |
| "Our previous studies indicated that the benzene metabolite hydroquinone (HQ) evokes the ROS/p38 MAPK/protein phosphatase 2A/tristetraprolin axis, leading to increased TNF-α expression in human acute myeloid leukemia cell lines U937 and HL-60." | 4.31 | Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells. ( Chang, LS; Chen, YJ; Chiou, JT; Lee, YC; Wang, LJ, 2023) |
| "Hydroquinone (HQ) is an important benzene-derived metabolite associated with acute myelogenous leukemia risk." | 3.83 | Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells. ( Bollati, V; Conti, A; Dieci, G; Favero, C; Fustinoni, S; Lazzari, L; Motta, V; Ragni, E; Rota, F, 2016) |
| "Studies on HQ-treated human leukemia K562 (Bcr/Abl-positive) cells were conducted to address the hydroquinone (HQ) mechanism that promotes soluble TNF-α (sTNF-α) production." | 3.79 | Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl. ( Chang, LS; Chen, YJ, 2013) |
| "This study investigated tumor necrosis factor-α (TNF-α)-mediated death pathway contribution to hydroquinone (HQ) cytotoxicity in human leukemia U937 cells." | 3.79 | p38 MAPK/PP2Acα/TTP pathway on the connection of TNF-α and caspases activation on hydroquinone-induced apoptosis. ( Chang, LS; Chou, WM; Liu, WH, 2013) |
| "Benzene is a known hematotoxic and leukemogenic chemical." | 1.91 | Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar-γ pathway. ( Cheng, X; Li, J; Lian, N; Lu, Y; Sui, P; Wang, QF; Xing, C; Xu, P; Zhou, J, 2023) |
| "Benzene is an established human and animal carcinogen." | 1.33 | Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene. ( Eastmond, DA; Hasegawa, L; Mondrala, ST, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, LJ | 1 |
| Lee, YC | 1 |
| Chiou, JT | 1 |
| Chen, YJ | 3 |
| Chang, LS | 4 |
| Xuan, M | 1 |
| Wu, Y | 1 |
| Wang, H | 1 |
| Ye, Z | 1 |
| Wu, H | 1 |
| Chen, Y | 1 |
| Yang, H | 1 |
| Tang, H | 1 |
| Lu, Y | 1 |
| Sui, P | 1 |
| Li, J | 1 |
| Lian, N | 1 |
| Zhou, J | 1 |
| Cheng, X | 1 |
| Wang, QF | 1 |
| Xing, C | 1 |
| Xu, P | 1 |
| Conti, A | 1 |
| Rota, F | 1 |
| Ragni, E | 1 |
| Favero, C | 1 |
| Motta, V | 1 |
| Lazzari, L | 1 |
| Bollati, V | 1 |
| Fustinoni, S | 1 |
| Dieci, G | 1 |
| Liu, WH | 2 |
| Chou, WM | 1 |
| Eastmond, DA | 2 |
| Mondrala, ST | 1 |
| Hasegawa, L | 1 |
| Rivedal, E | 1 |
| Witz, G | 1 |
| Levitt, J | 1 |
| Whysner, J | 1 |
| Verna, L | 1 |
| English, JC | 1 |
| Williams, GM | 1 |
| Lévay, G | 1 |
| Ross, D | 1 |
| Bodell, WJ | 1 |
| McDonald, TA | 1 |
| Holland, NT | 1 |
| Skibola, C | 1 |
| Duramad, P | 1 |
| Smith, MT | 2 |
| Robertson, ML | 1 |
| Yager, JW | 1 |
4 reviews available for hydroquinone and Leukemia
| Article | Year |
|---|---|
The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register.
Topics: Absorption; Adenoma; Animals; Carcinogenicity Tests; Drug Approval; Fertility; Humans; Hydroquinones | 2007 |
Analysis of studies related to tumorigenicity induced by hydroquinone.
Topics: Adenoma; Animals; Carcinogenicity Tests; Female; Humans; Hydroquinones; Kidney Neoplasms; Leukemia; | 1995 |
Hypothesis: phenol and hydroquinone derived mainly from diet and gastrointestinal flora activity are causal factors in leukemia.
Topics: Diet; Digestive System; Humans; Hydroquinones; Leukemia; Mutagens; Phenols | 2001 |
Role of metabolism in benzene-induced myelotoxicity and leukemogenesis.
Topics: Animals; Benzene; Biotransformation; Bone Marrow; Catechols; Cells, Cultured; Cytochrome P-450 Enzym | 1990 |
10 other studies available for hydroquinone and Leukemia
| Article | Year |
|---|---|
Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells.
Topics: Humans; Hydroquinones; Leukemia; MicroRNAs; NADPH Oxidase 4; Nucleotide Transport Proteins; Reactive | 2023 |
Effect of mir-92a-3p on hydroquinone induced changes in human lymphoblastoid cell cycle and apoptosis.
Topics: Animals; Apoptosis; Cell Division; Humans; Hydroquinones; Leukemia; Mice; Mice, Nude; MicroRNAs | 2023 |
Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar-γ pathway.
Topics: Animals; Benzene; Cell Proliferation; Hydroquinones; Leukemia; Mice; PPAR gamma | 2023 |
Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl.
Topics: ADAM Proteins; ADAM17 Protein; Base Sequence; Cell Line, Tumor; DNA Primers; Down-Regulation; Enzyme | 2013 |
Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells.
Topics: Cell Line; DNA; DNA Methylation; Dose-Response Relationship, Drug; Hematopoietic Stem Cells; Humans; | 2016 |
Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells.
Topics: ADAM17 Protein; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Transcription Fa | 2017 |
p38 MAPK/PP2Acα/TTP pathway on the connection of TNF-α and caspases activation on hydroquinone-induced apoptosis.
Topics: Activating Transcription Factor 2; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Caspase | 2013 |
Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene.
Topics: Benzene; Benzoquinones; Carcinogens; Dithiothreitol; DNA Topoisomerases, Type II; DNA, Kinetoplast; | 2005 |
Benzene metabolites block gap junction intercellular communication. Role in hematotoxicity and leukemia?
Topics: Aldehydes; Animals; Benzene; Cell Communication; Cell Line; Gap Junctions; Hematologic Diseases; Hyd | 2005 |
Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells, mouse bone marrow macrophages and human bone marrow.
Topics: Animals; Benzoquinones; Biotransformation; Bone Marrow; Cell Line; DNA; DNA, Neoplasm; Humans; Hydro | 1993 |