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hydroquinone and Leukemia

hydroquinone has been researched along with Leukemia in 14 studies

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Our previous studies indicated that the benzene metabolite hydroquinone (HQ) evokes the ROS/p38 MAPK/protein phosphatase 2A/tristetraprolin axis, leading to increased TNF-α expression in human acute myeloid leukemia cell lines U937 and HL-60."8.31Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells. ( Chang, LS; Chen, YJ; Chiou, JT; Lee, YC; Wang, LJ, 2023)
"Hydroquinone (HQ) is an important benzene-derived metabolite associated with acute myelogenous leukemia risk."7.83Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells. ( Bollati, V; Conti, A; Dieci, G; Favero, C; Fustinoni, S; Lazzari, L; Motta, V; Ragni, E; Rota, F, 2016)
"Studies on HQ-treated human leukemia K562 (Bcr/Abl-positive) cells were conducted to address the hydroquinone (HQ) mechanism that promotes soluble TNF-α (sTNF-α) production."7.79Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl. ( Chang, LS; Chen, YJ, 2013)
"Recently, the US Food and Drug Administration proposed a ban on over-the-counter hydroquinone mainly on the basis of high absorption, reports of exogenous ochronosis in humans, and murine hepatic adenomas, renal adenomas, and leukemia with large doses over extended time periods."4.84The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register. ( Levitt, J, 2007)
"Hydroquinone (HQ) produced renal adenomas in male F344 rats, and these tumors appeared to arise from areas of spontaneous progressive nephropathy; the nephropathy itself has been found to be enhanced by HQ."4.79Analysis of studies related to tumorigenicity induced by hydroquinone. ( English, JC; Verna, L; Whysner, J; Williams, GM, 1995)
"Our previous studies indicated that the benzene metabolite hydroquinone (HQ) evokes the ROS/p38 MAPK/protein phosphatase 2A/tristetraprolin axis, leading to increased TNF-α expression in human acute myeloid leukemia cell lines U937 and HL-60."4.31Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells. ( Chang, LS; Chen, YJ; Chiou, JT; Lee, YC; Wang, LJ, 2023)
"Hydroquinone (HQ) is an important benzene-derived metabolite associated with acute myelogenous leukemia risk."3.83Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells. ( Bollati, V; Conti, A; Dieci, G; Favero, C; Fustinoni, S; Lazzari, L; Motta, V; Ragni, E; Rota, F, 2016)
"Studies on HQ-treated human leukemia K562 (Bcr/Abl-positive) cells were conducted to address the hydroquinone (HQ) mechanism that promotes soluble TNF-α (sTNF-α) production."3.79Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl. ( Chang, LS; Chen, YJ, 2013)
"This study investigated tumor necrosis factor-α (TNF-α)-mediated death pathway contribution to hydroquinone (HQ) cytotoxicity in human leukemia U937 cells."3.79p38 MAPK/PP2Acα/TTP pathway on the connection of TNF-α and caspases activation on hydroquinone-induced apoptosis. ( Chang, LS; Chou, WM; Liu, WH, 2013)
"Benzene is a known hematotoxic and leukemogenic chemical."1.91Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar-γ pathway. ( Cheng, X; Li, J; Lian, N; Lu, Y; Sui, P; Wang, QF; Xing, C; Xu, P; Zhou, J, 2023)
"Benzene is an established human and animal carcinogen."1.33Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene. ( Eastmond, DA; Hasegawa, L; Mondrala, ST, 2005)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (21.43)18.2507
2000's4 (28.57)29.6817
2010's4 (28.57)24.3611
2020's3 (21.43)2.80

Authors

AuthorsStudies
Wang, LJ1
Lee, YC1
Chiou, JT1
Chen, YJ3
Chang, LS4
Xuan, M1
Wu, Y1
Wang, H1
Ye, Z1
Wu, H1
Chen, Y1
Yang, H1
Tang, H1
Lu, Y1
Sui, P1
Li, J1
Lian, N1
Zhou, J1
Cheng, X1
Wang, QF1
Xing, C1
Xu, P1
Conti, A1
Rota, F1
Ragni, E1
Favero, C1
Motta, V1
Lazzari, L1
Bollati, V1
Fustinoni, S1
Dieci, G1
Liu, WH2
Chou, WM1
Eastmond, DA2
Mondrala, ST1
Hasegawa, L1
Rivedal, E1
Witz, G1
Levitt, J1
Whysner, J1
Verna, L1
English, JC1
Williams, GM1
Lévay, G1
Ross, D1
Bodell, WJ1
McDonald, TA1
Holland, NT1
Skibola, C1
Duramad, P1
Smith, MT2
Robertson, ML1
Yager, JW1

Reviews

4 reviews available for hydroquinone and Leukemia

ArticleYear
The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register.
    Journal of the American Academy of Dermatology, 2007, Volume: 57, Issue:5

    Topics: Absorption; Adenoma; Animals; Carcinogenicity Tests; Drug Approval; Fertility; Humans; Hydroquinones

2007
Analysis of studies related to tumorigenicity induced by hydroquinone.
    Regulatory toxicology and pharmacology : RTP, 1995, Volume: 21, Issue:1

    Topics: Adenoma; Animals; Carcinogenicity Tests; Female; Humans; Hydroquinones; Kidney Neoplasms; Leukemia;

1995
Hypothesis: phenol and hydroquinone derived mainly from diet and gastrointestinal flora activity are causal factors in leukemia.
    Leukemia, 2001, Volume: 15, Issue:1

    Topics: Diet; Digestive System; Humans; Hydroquinones; Leukemia; Mutagens; Phenols

2001
Role of metabolism in benzene-induced myelotoxicity and leukemogenesis.
    Progress in clinical and biological research, 1990, Volume: 340B

    Topics: Animals; Benzene; Biotransformation; Bone Marrow; Catechols; Cells, Cultured; Cytochrome P-450 Enzym

1990

Other Studies

10 other studies available for hydroquinone and Leukemia

ArticleYear
Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells.
    Cell biology and toxicology, 2023, Volume: 39, Issue:5

    Topics: Humans; Hydroquinones; Leukemia; MicroRNAs; NADPH Oxidase 4; Nucleotide Transport Proteins; Reactive

2023
Effect of mir-92a-3p on hydroquinone induced changes in human lymphoblastoid cell cycle and apoptosis.
    Environmental toxicology, 2023, Volume: 38, Issue:6

    Topics: Animals; Apoptosis; Cell Division; Humans; Hydroquinones; Leukemia; Mice; Mice, Nude; MicroRNAs

2023
Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar-γ pathway.
    Toxicology letters, 2023, Jun-01, Volume: 382

    Topics: Animals; Benzene; Cell Proliferation; Hydroquinones; Leukemia; Mice; PPAR gamma

2023
Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl.
    Biochemical pharmacology, 2013, Sep-01, Volume: 86, Issue:5

    Topics: ADAM Proteins; ADAM17 Protein; Base Sequence; Cell Line, Tumor; DNA Primers; Down-Regulation; Enzyme

2013
Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells.
    Biochemical and biophysical research communications, 2016, 06-10, Volume: 474, Issue:4

    Topics: Cell Line; DNA; DNA Methylation; Dose-Response Relationship, Drug; Hematopoietic Stem Cells; Humans;

2016
Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells.
    Archives of toxicology, 2017, Volume: 91, Issue:2

    Topics: ADAM17 Protein; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Transcription Fa

2017
p38 MAPK/PP2Acα/TTP pathway on the connection of TNF-α and caspases activation on hydroquinone-induced apoptosis.
    Carcinogenesis, 2013, Volume: 34, Issue:4

    Topics: Activating Transcription Factor 2; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Caspase

2013
Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene.
    Chemico-biological interactions, 2005, May-30, Volume: 153-154

    Topics: Benzene; Benzoquinones; Carcinogens; Dithiothreitol; DNA Topoisomerases, Type II; DNA, Kinetoplast;

2005
Benzene metabolites block gap junction intercellular communication. Role in hematotoxicity and leukemia?
    Chemico-biological interactions, 2005, May-30, Volume: 153-154

    Topics: Aldehydes; Animals; Benzene; Cell Communication; Cell Line; Gap Junctions; Hematologic Diseases; Hyd

2005
Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells, mouse bone marrow macrophages and human bone marrow.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: Animals; Benzoquinones; Biotransformation; Bone Marrow; Cell Line; DNA; DNA, Neoplasm; Humans; Hydro

1993