Page last updated: 2024-10-18

hydroquinone and Facial Dermatoses

hydroquinone has been researched along with Facial Dermatoses in 31 studies

Facial Dermatoses: Skin diseases involving the FACE.

Research Excerpts

ExcerptRelevanceReference
"In this prospective pilot study, we evaluated the efficacy and safety for a novel combination therapy based on low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's melanosis."7.85A pilot study for triple combination therapy with a low-fluence 1064 nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's Melanosis. ( Choi, SC; Jung, JY; Kwon, HH; Kwon, IH; Ohn, J; Park, GH; Park, HY; Suh, DH, 2017)
"

Purpose: Though hydroquinone (HQ) remains the gold standard for treatment of hyperpigmentation, concerns about its safety have prompted the development of HQ-free topical skin lightening systems."

5.24A Randomized, Investigator-Blinded Comparison of Two Topical Regimens in Fitzpatrick Skin Types III-VI With Moderate to Severe Facial Hyperpigmentation. ( Bolton, J; Goldman, MP; Jones, IT; Larsen, L; Vanaman Wilson, MJ; Wu, DC, 2017)
"There was no significant difference in the incidence of post-CO2 laser resurfacing hyperpigmentation between subjects who received pretreatment with either topical glycolic acid cream or combination tretinoin/hydroquinone creams and those who received no pretreatment regimen."5.09Effect of pretreatment on the incidence of hyperpigmentation following cutaneous CO2 laser resurfacing. ( Alster, TS; West, TB, 1999)
"In this prospective pilot study, we evaluated the efficacy and safety for a novel combination therapy based on low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's melanosis."3.85A pilot study for triple combination therapy with a low-fluence 1064 nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's Melanosis. ( Choi, SC; Jung, JY; Kwon, HH; Kwon, IH; Ohn, J; Park, GH; Park, HY; Suh, DH, 2017)
"We present a case of exogenous ochronosis in a 53-year-old woman with skin type IV, who used a topical hydroquinone preparation of an unknown concentration for several years."3.80Exogenous ochronosis. ( Hale, CS; Leger, M; Meehan, SA; Nagler, A, 2014)
"Exogenous ochronosis (EO), a disfiguring cutaneous complication of topical hydroquinone use, is difficult to treat."3.79Exogenous ochronosis - successful outcome after treatment with Q-switched Nd:YAG laser. ( Tan, SK, 2013)
"We describe a 63-year-old Hispanic woman who developed exogenous ochronosis lesions on her face after using topical bleaching creams containing hydroquinone, 2% to 3%, and oxybenzone, 2%, for several years."3.76Dermoscopic and reflectance confocal microscopic features of exogenous ochronosis. ( Gil, I; Herrero-González, JE; Lloreta, J; Martínez-Escala, E; Puig, S; Pujol, RM; Segura, S; Vélez, M, 2010)
"A 55-year-old woman with melasma develops biopsy-proved exogenous ochronosis in the setting of prolonged topical hydroquinone use."3.74Exogenous ochronosis. ( Brown, L; Meehan, S; Merola, JF; Walters, RF, 2008)
" Safety was assessed through the reporting of adverse events."2.73A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma. ( Chan, R; Chang, SE; Kerrouche, N; Lee, ES; Lee, MH; Legarda-Montinola, F; Leow, YH; Park, KC; Shek, S; Tay, YK; Thomas, G; Tsai, RY; Tsai, TH; Verallo-Rowell, V, 2008)
"Melasma is a common hyperpigmentation disorder that is frequently recalcitrant to treatment."2.72Community-based trial of a triple-combination agent for the treatment of facial melasma. ( Grimes, P; Kelly, AP; Torok, H; Willis, I, 2006)
" only 3 patients (1%) withdrew from the study due to treatment-related adverse events (AEs)."2.71Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12-month treatment for melasma. ( Jones, T; Rich, P; Smith, S; Torok, HM; Tschen, E, 2005)
"Melasma is difficult to clear."2.69Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. ( Lim, JT, 1999)
"Acne was the most frequent motive for consulting (24%), followed by the paradoxical peri-orbital hyperpigmentation (21."1.33[Reasons for consulting related to skin-bleaching products used by 104 women in Brazzaville]. ( Gathse, A; Ibara, JR, 2005)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.23)18.7374
1990's7 (22.58)18.2507
2000's12 (38.71)29.6817
2010's11 (35.48)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pirrone, J1
Broyer, J1
Otte, N1
Reich, K1
Boer-Auer, A1
Vanaman Wilson, MJ1
Jones, IT1
Bolton, J1
Larsen, L1
Wu, DC1
Goldman, MP1
Sánchez-Martínez, EM1
García-Briz, MI1
Moneva-Léniz, LM1
Gegúndez-Hernández, H1
Pose-Lapausa, P1
Mateu-Puchades, A1
Tan, SK1
Kindem, S1
Serra-Guillén, C1
Guillén, C1
Nagler, A1
Hale, CS1
Meehan, SA1
Leger, M1
Cinotti, E1
Labeille, B1
Douchet, C1
Cambazard, F1
Perrot, JL1
Kwon, HH1
Ohn, J1
Suh, DH1
Park, HY1
Choi, SC1
Jung, JY1
Kwon, IH1
Park, GH1
Sarkar, R1
Parmar, NV1
Kapoor, S1
Córdova, ME1
Pérez-Rojas, DO1
López-Marquet, AD1
Arenas, R1
Chan, R1
Park, KC1
Lee, MH1
Lee, ES1
Chang, SE1
Leow, YH1
Tay, YK1
Legarda-Montinola, F1
Tsai, RY1
Tsai, TH1
Shek, S1
Kerrouche, N1
Thomas, G1
Verallo-Rowell, V1
Merola, JF1
Meehan, S1
Walters, RF1
Brown, L1
Gil, I1
Segura, S1
Martínez-Escala, E1
Lloreta, J1
Puig, S1
Vélez, M1
Pujol, RM1
Herrero-González, JE1
Yoon, TY1
Lee, GC1
Kim, YG1
Kim, MK1
Kim, CY1
Grimes, PE1
Torok, HM1
Jones, T1
Rich, P1
Smith, S1
Tschen, E1
Gathse, A1
Ibara, JR1
Grimes, P1
Kelly, AP1
Torok, H1
Willis, I1
Hexsel, D1
Arellano, I1
Rendon, M1
Ferreira Cestari, T1
Hassun, K1
Sittart, A1
de Lourdes Viegas, M1
Lupo, MP1
Jacyk, WK1
Rubin, MG1
Camarasa, JG1
Serra-Baldrich, E1
Snider, RL1
Thiers, BH1
Apfelberg, DB1
West, TB1
Alster, TS1
Lim, JT1
Ozluer, SM1
Muir, J1
Barrientos, N1
Ortiz-Frutos, J1
Gómez, E1
Iglesias, L1
Melli, MC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Solar Lentigines Treatment With the Triple Combination Cream (Hydroquinone 4%, Tretinoin 0.05%, and Fluocinolone Acetonide 0.01%). Randomized, Double Blind, Controlled Trial.[NCT00975312]Phase 222 participants (Actual)Interventional2008-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

9 trials available for hydroquinone and Facial Dermatoses

ArticleYear
A Randomized, Investigator-Blinded Comparison of Two Topical Regimens in Fitzpatrick Skin Types III-VI With Moderate to Severe Facial Hyperpigmentation.
    Journal of drugs in dermatology : JDD, 2017, Nov-01, Volume: 16, Issue:11

    Topics: Administration, Cutaneous; Adult; Aged; Dermatologic Agents; Facial Dermatoses; Female; Humans; Hydr

2017
Treatment of Postinflammatory Hyperpigmentation With a Combination of Glycolic Acid Peels and a Topical Regimen in Dark-Skinned Patients: A Comparative Study.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2017, Volume: 43, Issue:4

    Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents; Chemexfoliation; Drug Combinations; Faci

2017
A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma.
    The British journal of dermatology, 2008, Volume: 159, Issue:3

    Topics: Administration, Cutaneous; Adult; Analysis of Variance; Asian People; Double-Blind Method; Drug Comb

2008
A microsponge formulation of hydroquinone 4% and retinol 0.15% in the treatment of melasma and postinflammatory hyperpigmentation.
    Cutis, 2004, Volume: 74, Issue:6

    Topics: Administration, Topical; Adult; Dermatologic Agents; Drug Administration Schedule; Drug Combinations

2004
Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12-month treatment for melasma.
    Cutis, 2005, Volume: 75, Issue:1

    Topics: Antioxidants; Drug Combinations; Facial Dermatoses; Female; Fluocinolone Acetonide; Glucocorticoids;

2005
Community-based trial of a triple-combination agent for the treatment of facial melasma.
    Cutis, 2006, Volume: 77, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Dermato

2006
A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasma.
    Journal of cosmetic dermatology, 2007, Volume: 6, Issue:1

    Topics: Administration, Topical; Adult; Drug Combinations; Emollients; Facial Dermatoses; Female; Fluocinolo

2007
Effect of pretreatment on the incidence of hyperpigmentation following cutaneous CO2 laser resurfacing.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1999, Volume: 25, Issue:1

    Topics: Administration, Cutaneous; Adult; Carbon Dioxide; Dermatologic Surgical Procedures; Facial Dermatose

1999
Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1999, Volume: 25, Issue:4

    Topics: Adult; Aspergillus oryzae; Double-Blind Method; Drug Combinations; Facial Dermatoses; Female; Gels;

1999

Other Studies

22 other studies available for hydroquinone and Facial Dermatoses

ArticleYear
Extensive hyperpigmentation of the face in a Filipina.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2017, Volume: 15, Issue:11

    Topics: Administration, Topical; Diagnosis, Differential; Facial Dermatoses; Female; Hispanic or Latino; Hum

2017
Exogenous ochronosis: the failure of depigmenting creams.
    Dermatology online journal, 2019, Apr-15, Volume: 25, Issue:4

    Topics: Antioxidants; Back; Facial Dermatoses; Female; Humans; Hydroquinones; Hyperpigmentation; Middle Aged

2019
Exogenous ochronosis - successful outcome after treatment with Q-switched Nd:YAG laser.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2013, Volume: 15, Issue:5

    Topics: Adult; Aged; Asian People; Facial Dermatoses; Female; Humans; Hydroquinones; Hyperpigmentation; Lase

2013
Patchy facial hyperpigmentation.
    Actas dermo-sifiliograficas, 2015, Volume: 106, Issue:4

    Topics: Facial Dermatoses; Female; Humans; Hydroquinones; Middle Aged; Ochronosis; Skin Lightening Preparati

2015
Exogenous ochronosis.
    Dermatology online journal, 2014, Dec-16, Volume: 20, Issue:12

    Topics: Antioxidants; Facial Dermatoses; Female; Humans; Hydroquinones; Middle Aged; Ochronosis

2014
[Role of dermoscopy and reflectance confocal microscopy as an aid in the diagnosis of exogenous ochronosis].
    Annales de dermatologie et de venereologie, 2016, Volume: 143, Issue:4

    Topics: Adult; Biopsy; Dermoscopy; Facial Dermatoses; Female; Humans; Hydroquinones; Macrophages; Melanins;

2016
A pilot study for triple combination therapy with a low-fluence 1064 nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's Melanosis.
    The Journal of dermatological treatment, 2017, Volume: 28, Issue:2

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Combined Modality Therapy; Erythema; Facial

2017
Exogenous Ochronosis in Facial Melasma.
    Actas dermo-sifiliograficas, 2017, Volume: 108, Issue:4

    Topics: Dermoscopy; Facial Dermatoses; Female; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Hyd

2017
Exogenous ochronosis.
    Dermatology online journal, 2008, Oct-15, Volume: 14, Issue:10

    Topics: Dermatologic Agents; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Hydroquinones; Mela

2008
Dermoscopic and reflectance confocal microscopic features of exogenous ochronosis.
    Archives of dermatology, 2010, Volume: 146, Issue:9

    Topics: Benzophenones; Biopsy, Needle; Cosmetics; Dermoscopy; Facial Dermatoses; Female; Follow-Up Studies;

2010
A case of idiopathic eruptive macular pigmentation.
    The Journal of dermatology, 2004, Volume: 31, Issue:5

    Topics: Adult; Diagnosis, Differential; Dicarboxylic Acids; Facial Dermatoses; Female; Humans; Hydroquinones

2004
[Reasons for consulting related to skin-bleaching products used by 104 women in Brazzaville].
    Bulletin de la Societe de pathologie exotique (1990), 2005, Volume: 98, Issue:5

    Topics: Acne Vulgaris; Adolescent; Adrenal Cortex Hormones; Adult; Congo; Cosmetics; Dermatologic Agents; De

2005
Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation.
    The British journal of dermatology, 2006, Volume: 156 Suppl 1

    Topics: Administration, Topical; Drug Therapy, Combination; Facial Dermatoses; Fluocinolone Acetonide; Gluco

2006
Dermatosis papulosis nigra: treatment options.
    Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:1

    Topics: Black People; Facial Dermatoses; Female; Humans; Hydroquinones; Laser Therapy; Postoperative Care; R

2007
Annular granulomatous lesions in exogenous ochronosis are manifestation of sarcoidosis.
    The American Journal of dermatopathology, 1995, Volume: 17, Issue:1

    Topics: Adult; Aged; Collagen; Diagnosis, Differential; Elastic Tissue; Eosinophils; Facial Dermatoses; Fema

1995
Chemical peeling as adjuvant therapy for facial neurotic excoriations.
    Journal of the American Academy of Dermatology, 1995, Volume: 32, Issue:2 Pt 1

    Topics: Chemexfoliation; Facial Dermatoses; Glycolates; Humans; Hydroquinones; Hydroxy Acids; Neurotic Disor

1995
Exogenous ochronosis with allergic contact dermatitis from hydroquinone.
    Contact dermatitis, 1994, Volume: 31, Issue:1

    Topics: Dermatitis, Allergic Contact; Drug Eruptions; Facial Dermatoses; Female; Humans; Hydroquinones; Midd

1994
Exogenous ochronosis.
    Journal of the American Academy of Dermatology, 1993, Volume: 28, Issue:4

    Topics: Administration, Cutaneous; Dermatologic Agents; Facial Dermatoses; Female; Humans; Hydroquinones; Mi

1993
Ultrapulse carbon dioxide laser with CPG scanner for full-face resurfacing for rhytids, photoaging, and acne scars.
    Plastic and reconstructive surgery, 1997, Volume: 99, Issue:7

    Topics: Acne Vulgaris; Acyclovir; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antiviral Agents

1997
Nail staining from hydroquinone cream.
    The Australasian journal of dermatology, 2000, Volume: 41, Issue:4

    Topics: Administration, Topical; Adult; Coloring Agents; Facial Dermatoses; Follow-Up Studies; Humans; Hydro

2000
Allergic contact dermatitis from a bleaching cream.
    American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 2001, Volume: 12, Issue:1

    Topics: Allergens; Dermatitis, Allergic Contact; Diagnosis, Differential; Facial Dermatoses; Female; Humans;

2001
[Clinical evaluation of the efficacy of a topical preparation containing 2% hydroquinone in chloasma].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1987, Volume: 122, Issue:12

    Topics: Administration, Topical; Adult; Facial Dermatoses; Female; Humans; Hydroquinones; Melanosis; Middle

1987