Page last updated: 2024-10-18

hydroquinone and Chloasma

hydroquinone has been researched along with Chloasma in 133 studies

Research Excerpts

ExcerptRelevanceReference
"To evaluate the use of a nonablative, fractional, 1,927-nm diode laser with and without topical 2% hydroquinone (HQ) cream for moderate-to-severe facial hyperpigmentation in Fitzpatrick skin Types III-V."9.27The Safety and Efficacy of Treatment With a 1,927-nm Diode Laser With and Without Topical Hydroquinone for Facial Hyperpigmentation and Melasma in Darker Skin Types. ( Bolton, J; Fabi, SG; Jones, IT; Larsen, L; Vanaman Wilson, MJ, 2018)
"To observe and analyze the efficacy of tranexamic acid combined with reduced glutathione in chloasma treatment."9.27Clinical observation on tranexamic acid combined with reduced glutathione for the treatment of chloasma. ( Feng, C; Yan, M, 2018)
"Determine the efficacy and tolerability of a topical, non-hydroquinone, non-retinol pigment-correcting serum (LYT2) for the treatment of pregnancy-induced melasma."8.12Pigmentation control in pregnancy-induced melasma: Clinical assessment of a non-hydroquinone, non-retinol pigment-correcting serum. ( Jiang, LI; Makino, ET; Mehta, RC; Mikati, M; Stephens, TJ, 2022)
"In this prospective pilot study, we evaluated the efficacy and safety for a novel combination therapy based on low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's melanosis."7.85A pilot study for triple combination therapy with a low-fluence 1064 nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's Melanosis. ( Choi, SC; Jung, JY; Kwon, HH; Kwon, IH; Ohn, J; Park, GH; Park, HY; Suh, DH, 2017)
"  Three cases of suspected hydroquinone-induced exogenous ochronosis while treating melasma were subjected to dermatoscopy and histopathology studies."7.79Diagnostic utility of dermatoscopy in hydroquinone-induced exogenous ochronosis. ( Deshpande, DJ; Dhurat, RS; Mishra, SN; Nayak, CS, 2013)
"Although bleaching treatment using all-trans retinoic acid (RA) and hydroquinone (HQ) improves epidermal melanosis, the application of two medications and the irritant dermatitis induced by RA inconvenience patients."7.79Silicone sheet containing all-trans retinoic acid and hydroquinone for the treatment of epidermal melanosis. ( Harii, K; Iida, S; Kurita, M; Ohura, N; Sato, S; Takushima, A, 2013)
"Melasma is a common disorder affecting a significant percentage of the population, particularly those with skin of color."6.74A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream. ( Bhawan, J; Byers, HR; Colón, LE; Gottschalk, R; Grimes, P; Guevara, IL; Johnson, LA; Keady, M; Pandya, AG, 2009)
"Melasma is a common hyperpigmented skin condition that occurs on the face and other areas prone to light exposure, seriously affecting people's quality of life."5.91Hydroquinone cream-based polymer microneedle roller for the combined treatment of large-area chloasma. ( Chen, BZ; Cui, Y; Guo, XD; Hao, YY; He, YT; Yu, RX; Zhang, C, 2023)
" The principal adverse effects of its chronic use are confetti-like depigmentation and exogenous ochronosis."5.35Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy. ( Azulay-Abulafia, L; Barcaui, CB; Charlín, R; Kac, BK; Rabello-Fonseca, R; Soares, DB, 2008)
"To observe and analyze the efficacy of tranexamic acid combined with reduced glutathione in chloasma treatment."5.27Clinical observation on tranexamic acid combined with reduced glutathione for the treatment of chloasma. ( Feng, C; Yan, M, 2018)
"To evaluate the use of a nonablative, fractional, 1,927-nm diode laser with and without topical 2% hydroquinone (HQ) cream for moderate-to-severe facial hyperpigmentation in Fitzpatrick skin Types III-V."5.27The Safety and Efficacy of Treatment With a 1,927-nm Diode Laser With and Without Topical Hydroquinone for Facial Hyperpigmentation and Melasma in Darker Skin Types. ( Bolton, J; Fabi, SG; Jones, IT; Larsen, L; Vanaman Wilson, MJ, 2018)
"To evaluate the erythema and pigmentation of melasma lesions and the surrounding areas in patients receiving triple combination (TC: hydroquinone, tretinoin, and fluocinolone acetonide) regimens."5.19Objective assessment of erythema and pigmentation of melasma lesions and surrounding areas in long-term management regimens with triple combination. ( Fernandes, JD; Hexsel, D; Siega, C; Soirefmann, M, 2014)
"Hydroquinone is superior to tretinoin as a priming agent in maintaining the results achieved with peels and in decreasing the incidence of postpeel reactive hyperpigmentation."5.11Efficacy of hydroquinone (2%) versus tretinoin (0.025%) as adjunct topical agents for chemical peeling in patients of melasma. ( Grover, C; Nanda, S; Reddy, BS, 2004)
"Determine the efficacy and tolerability of a topical, non-hydroquinone, non-retinol pigment-correcting serum (LYT2) for the treatment of pregnancy-induced melasma."4.12Pigmentation control in pregnancy-induced melasma: Clinical assessment of a non-hydroquinone, non-retinol pigment-correcting serum. ( Jiang, LI; Makino, ET; Mehta, RC; Mikati, M; Stephens, TJ, 2022)
"In this prospective pilot study, we evaluated the efficacy and safety for a novel combination therapy based on low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's melanosis."3.85A pilot study for triple combination therapy with a low-fluence 1064 nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's Melanosis. ( Choi, SC; Jung, JY; Kwon, HH; Kwon, IH; Ohn, J; Park, GH; Park, HY; Suh, DH, 2017)
"  Three cases of suspected hydroquinone-induced exogenous ochronosis while treating melasma were subjected to dermatoscopy and histopathology studies."3.79Diagnostic utility of dermatoscopy in hydroquinone-induced exogenous ochronosis. ( Deshpande, DJ; Dhurat, RS; Mishra, SN; Nayak, CS, 2013)
"Although bleaching treatment using all-trans retinoic acid (RA) and hydroquinone (HQ) improves epidermal melanosis, the application of two medications and the irritant dermatitis induced by RA inconvenience patients."3.79Silicone sheet containing all-trans retinoic acid and hydroquinone for the treatment of epidermal melanosis. ( Harii, K; Iida, S; Kurita, M; Ohura, N; Sato, S; Takushima, A, 2013)
"A 55-year-old woman with melasma develops biopsy-proved exogenous ochronosis in the setting of prolonged topical hydroquinone use."3.74Exogenous ochronosis. ( Brown, L; Meehan, S; Merola, JF; Walters, RF, 2008)
"Hydroquinone has been successfully used to treat hyperpigmentation disorders for many years."3.72Lustra, Lustra-AF and Alustra. ( Gupta, AK; Ryder, JE, 2003)
" The hydroquinone 4% cohort experienced 5 adverse events, while there were no adverse events associated with the novel topical product."3.30A Multi-Center, Randomized, Blinded Clinical Study Evaluating the Efficacy and Safety of a Novel Topical Product for Facial Dyschromia. ( Bajaj, S; Bell, M; Fabi, S; Geronemus, R; Robinson, D; Wang, J; Widgerow, A, 2023)
" Original studies that reported pre- and post-treatment Melasma Area Severity Index (MASI)/modified Melasma Area Severity Index (mMASI) scores and/or adverse effects (AEs) were eligible for inclusion."3.01Efficacy and safety of topical agents in the treatment of melasma: What's evidence? A systematic review and meta-analysis. ( Aljabban, A; Bain, PA; Bay, CP; Chang, YF; Chung, HJ; Desai, SR; Lee, TL; Oyerinde, O, 2023)
"Tranexamic acid (TXA) is a plasmin inhibitor used off-label in the treatment of melasma."3.01Tranexamic acid in melasma: A focused review on drug administration routes. ( Balazic, E; Jaller, JA; Khanna, U; Kobets, K; Konisky, H, 2023)
"Hydroquinone cream was generally better tolerated that cysteamine cream."3.01Evaluation of the efficacy of cysteamine cream compared to hydroquinone in the treatment of melasma: A randomised, double-blinded trial. ( Chung, IY; Gourani-Tehrani, S; Honigman, A; Nguyen, J; Paul, E; Remyn, L; Rodrigues, M; Wong, C; Wutami, I, 2021)
"Melasma is a common acquired pigmentary disorder characterized by symmetric hyperpigmented macules on the face."2.94Topical metformin in the treatment of melasma: A preliminary clinical trial. ( Andanooru Chandrappa, NK; Banavase Channakeshavaiah, R, 2020)
"Melasma is a common pigmentary disorder for which oral tranexamic acid has shown some efficacy in previous studies."2.94Randomised, controlled, double-blind study of combination therapy of oral tranexamic acid and topical hydroquinone in the treatment of melasma. ( Agustin, T; Legiawati, L; Pandya, AG; Prihartono, J; Shihab, N; Tovar-Garza, A, 2020)
"Melasma is a pigmentary disorder affecting mainly face ."2.94Study of oral tranexamic acid, topical tranexamic acid, and modified Kligman's regimen in treatment of melasma. ( Jawade, S; Kulkarni, S; Madke, B; Sahu, PJ; Saoji, V; Singh, AL, 2020)
"Melasma is a common disorder of hyperpigmentation that disproportionately affects individuals with skin of color."2.94Randomized, Double-Blinded, Split-Face Study Comparing the Efficacy and Tolerability of Two Topical Products for Melasma. ( Alexis, AF; Kaufman, BP, 2020)
"The management of melasma is still challenging, and new treatment modalities with favorable side effect profile are required."2.94The efficacy and safety of topical 5% methimazole vs 4% hydroquinone in the treatment of melasma: A randomized controlled trial. ( Dadkhahfar, S; Gheisari, M; Moghimi, HR; Najar Nobari, N; Niknejad, N; Olamaei, E, 2020)
"Hydroquinone is the basic treatment that its effect alone and in combination with other medications has been proven."2.90Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma. ( Banihashemi, M; Dorri, M; Golnouri, F; Jaafari, MR; Marhamati, H; Salehi, M; Taghavi, F; Zabolinejad, N, 2019)
"Melasma is a pigmentary disorder characterized by hyperpigmented patchy skin in sun-exposed areas, especially the face."2.90Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma. ( Arrowitz, C; Jiang, LI; Kolbe, L; Mann, T; Schoelermann, AM; Weber, T, 2019)
"Tranexamic acid (TA) is a relatively new brightening agent that interferes with keratinocyte-melanocyte interactions."2.87Comparing the efficacy of topical hydroquinone 2% versus intradermal tranexamic acid microinjections in treating melasma: a split-face controlled trial. ( Darayesh, M; Heiran, A; Saki, N, 2018)
" No serious adverse events were reported."2.84Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split-face, 2% hydroquinone cream-controlled clinical trial. ( Choi, YJ; Kim, BJ; Kim, JY; Kim, WS; Ko, EJ; Min, JH; Nam, JH; Park, KY, 2017)
"Melasma's high prevalence and profound psychological impact on patients necessitate efficacious, economical, and safe therapeutic interventions."2.84Comparison of the therapeutic efficacy and safety of combined oral tranexamic acid and topical hydroquinone 4% treatment vs. topical hydroquinone 4% alone in melasma: a parallel-group, assessor- and analyst-blinded, randomized controlled trial with a shor ( Abedini, R; Akbari, Z; Ghayoumi, A; Goodarzi, A; Hedayat, K; Hosseini, H; Lajevardi, V, 2017)
"Melasma is an abnormal acquired hyperpigmentation of the face of unknown origin, it is considered a single disease and very little has been found regarding its pathogenesis."2.82Raman spectroscopy analysis of the skin of patients with melasma before standard treatment with topical corticosteroids, retinoic acid, and hydroquinone mixture. ( Arenas, E; Castillo-Martínez, C; González, FJ; León-Bejarano, F; Moncada, B; Ramírez-Elías, MG, 2016)
"Melasma is a common acquired skin disorder."2.82Comparison between Intralesional Triamcinolone and Kligman's Formula in Treatment of Melasma. ( Eshghi, G; Esna Ashari, F; Khezrian, L, 2016)
"Melasma is acquired symmetric hypermelanosis characterized by light-to-deep brown pigmentation over cheeks, forehead, upper lip, and nose."2.82Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma. ( Bansal, S; Garg, V; Gupta, C; Sarkar, R; Sethi, S, 2016)
"Treatment of melasma is unsatisfactory most of the times."2.80The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial. ( Adalatkhah, H; Sadeghi-Bazargani, H, 2015)
"Melasma is one of the most common cosmetic disorders with skin darkening."2.80Comparison of therapeutic effects of liposomal Tranexamic Acid and conventional Hydroquinone on melasma. ( Banihashemi, M; Jaafari, MR; Jabari, A; Salehi, M; Zabolinejad, N, 2015)
"1%) reported adverse effects."2.80Efficacy and safety of fluocinolone acetonide, hydroquinone, and tretinoin cream in chinese patients with melasma: a randomized, double-blind, placebo-controlled, multicenter, parallel-group study. ( Dang, Y; Gong, Z; Lai, W; Li, L; Liu, L; Wang, X; Yang, Q; Zhao, G; Zheng, M; Zou, Y, 2015)
"Melasma is a common melanosis often difficult to treat."2.79Combination of fractional erbium-glass laser and topical therapy in melasma resistant to triple-combination cream. ( Bencini, PL; Galimberti, MG; Pellacani, G; Tourlaki, A, 2014)
" Adverse events were noted on every visit."2.79A randomized, double-blind, placebo-controlled clinical trial on the efficacy and safety of 3% Rumex occidentalis cream versus 4% hydroquinone cream in the treatment of melasma among Filipinos. ( Handog, EB; Mendoza, CG; Singzon, IA, 2014)
"Together these products offer not only treatment of melasma but also a complete skin care regimen."2.78Treating epidermal melasma with a 4% hydroquinone skin care system plus tretinoin cream 0.025%. ( Grimes, P; Watson, J, 2013)
"  Melasma is an irregular brown or grayish-brown symmetric facial hypermelanosis, often affecting women, especially those living in areas with intense ultraviolet radiation."2.76Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma. ( Farshi, S, 2011)
"Melasma is common among females."2.76Instrumental analysis of the pattern of improvement and that of recurrence of melasma in Thai females treated with Kligman-Willis triple combination therapy: confirmation by using its two different formulae. ( Pratchyapruit, W; Sindhavananda, J; Tagami, H; Vashrangsi, N, 2011)
"Melasma is a frequent skin disorder characterized by the appearance of abnormal pigment (melanin) deposits in different layers of the skin."2.75Characterization and evaluation of pigment distribution and response to therapy in melasma using in vivo reflectance confocal microscopy: a preliminary study. ( Ardigo, M; Berardesca, E; Cameli, N; Gonzalez, S, 2010)
"QS-Nd:YAG laser treatment for melasma in Asians produced only temporary improvement and had side effects."2.75Low-fluence Q-switched neodymium-doped yttrium aluminum garnet (1,064 nm) laser for the treatment of facial melasma in Asians. ( Eimpunth, S; Mornchan, R; Wattanakrai, P, 2010)
"Melasma is a common disorder affecting a significant percentage of the population, particularly those with skin of color."2.74A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream. ( Bhawan, J; Byers, HR; Colón, LE; Gottschalk, R; Grimes, P; Guevara, IL; Johnson, LA; Keady, M; Pandya, AG, 2009)
"Melasma is a common disorder of facial hyperpigmentation that can be resistant to treatment."2.74Melasma: treatment evaluation. ( Amer, A; Gamil, H; Harras, M; Ramadan, A; Salem, A, 2009)
" Safety was assessed through the reporting of adverse events."2.73A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma. ( Chan, R; Chang, SE; Kerrouche, N; Lee, ES; Lee, MH; Legarda-Montinola, F; Leow, YH; Park, KC; Shek, S; Tay, YK; Thomas, G; Tsai, RY; Tsai, TH; Verallo-Rowell, V, 2008)
"Melasma is a common hyperpigmentation disorder that is frequently recalcitrant to treatment."2.72Community-based trial of a triple-combination agent for the treatment of facial melasma. ( Grimes, P; Kelly, AP; Torok, H; Willis, I, 2006)
"Glycolic acid has been added to hydroquinone formulations in the past to enhance their depigmentation effects, but may cause irritation, leading to postinflammatory hyperpigmentation."2.71Safety and efficacy of 4% hydroquinone combined with 10% glycolic acid, antioxidants, and sunscreen in the treatment of melasma. ( Guevara, IL; Pandya, AG, 2003)
"Melasma is an acquired treatment-resistant hyperpigmentation of the skin."2.71A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma. ( Castanedo-Cazares, JP; Espinal-Perez, LE; Moncada, B, 2004)
" only 3 patients (1%) withdrew from the study due to treatment-related adverse events (AEs)."2.71Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12-month treatment for melasma. ( Jones, T; Rich, P; Smith, S; Torok, HM; Tschen, E, 2005)
"Melasma is a common problem in Asians, but treatments have not been satisfactory."2.69Intermittent therapy for melasma in Asian patients with combined topical agents (retinoic acid, hydroquinone and hydrocortisone): clinical and histological studies. ( Chun, SC; Kang, WH; Lee, S, 1998)
"Melasma is difficult to clear."2.69Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. ( Lim, JT, 1999)
"Melasma is a common disorder of macular hyperpigmentation which involves mostly in sun exposed areas of the face and neck."2.69Melasma. ( Kauh, YC; Zachian, TF, 1999)
"Melasma is a common disorder of facial hyperpigmentation among Asian women."2.68Glycolic acid peels in the treatment of melasma among Asian women. ( Lim, JT; Tham, SN, 1997)
"Melasma is a circumscribed brown macular hypermelanosis of the areas of the face and neck that are exposed to light."2.66Usefulness of retinoic acid in the treatment of melasma. ( Fitzpatrick, TB; Kraus, EW; Pathak, MA, 1986)
"Melasma is a macular hypermelanosis of the sun-exposed areas of the face and neck."2.66Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. ( Garcia-Lopez, M; Graupe, K; Lopez-Villafuerte, L; Verallo, V; Verallo-Rowell, VM, 1989)
"With proper treatment, melasma can be controlled, improved, and maintained; alternatively, PIH can be cured in most cases."2.53Melasma and Post Inflammatory Hyperpigmentation: Management Update and Expert Opinion. ( Emer, J; Prado, G; Sofen, B, 2016)
"Melasma is a commonly acquired hypermelanosis that affects sun-exposed areas of the skin, with frequent facial involvement."2.53Heterogeneous Pathology of Melasma and Its Clinical Implications. ( Hwang, YJ; Kwon, SH; Lee, SK; Park, KC, 2016)
"Melasma is a common acquired disorder of pigmentation most commonly seen in those with skin of colour."2.52Melasma: clinical diagnosis and management options. ( Pandya, AG; Rodrigues, M, 2015)
"Melasma is a complex multifactorial disorder whose pathogenesis is not well understood."2.48Treatment of melasma and the use of intense pulsed light: a review. ( Fabi, S; Goldman, MP; Zaleski, L, 2012)
"Melasma is a common, acquired facial skin disorder, mostly involving sun-exposed areas like cheeks, forehead and upper lip."2.47Melasma--updated treatments. ( Bolanca, Z; Kolić, M; Ljubicić, I; Misanović, B; Situm, M, 2011)
"Care must be taken when treating melasma to avoid inducing post-inflammatory hyperpigmentation and ochronosis."2.45Melasma in Latin America: options for therapy and treatment algorithm. ( Arellano, I; Cestari, T; Hexsel, D; Ortonne, JP, 2009)
"Melasma is a common disorder of hyperpigmentation and generally involves areas of the face and neck."2.43A comprehensive review of the long-term and short-term treatment of melasma with a triple combination cream. ( Torok, HM, 2006)
"Melasma is an irregular brown or grayish-brown facial hypermelanosis, often affecting women, especially those living in areas of intense UV radiation."2.43The treatment of melasma: a review of clinical trials. ( Gover, MD; Gupta, AK; Nouri, K; Taylor, S, 2006)
"Melasma is a common acquired symmetric hypermelanosis characterized by irregular light- to gray-brown macules and patches involving sun-exposed areas of skin."2.39Melasma. Etiologic and therapeutic considerations. ( Grimes, PE, 1995)
" While many pharmaceutical (topical or systemic) or procedural (lasers/chemical peels) options are available, some treatments are not safe/tolerable for long-term use or can induce/exacerbate PIH."1.91Topical Treatments for Melasma and Post-inflammatory Hyperpigmentation. ( Abidi, Z; Arruda, S; Pannu, S; Sadick, N, 2023)
"The aim of this study was to assess the effectiveness of photo rejuvenation combined with tranexamic acid and hydroquinone cream in the treatment of complex facial pigmentation."1.91Efficacy of photorejuvenation combined with tranexamic acid and hydroquinone cream in the treatment of complex facial pigmentation. ( Lin, C; Zhu, X, 2023)
"The search for new compounds for the treatment of melasma without side effects is constant."1.91Analysis of the antimelanogenic activity of zinc and selenium in vitro. ( da Silva, ACC; de Souza da Costa, N; Galiciolli, MEA; Irioda, AC; Oliveira, CS; Ribeiro, MM; Souza, JV, 2023)
"Melasma is a common hyperpigmented skin condition that occurs on the face and other areas prone to light exposure, seriously affecting people's quality of life."1.91Hydroquinone cream-based polymer microneedle roller for the combined treatment of large-area chloasma. ( Chen, BZ; Cui, Y; Guo, XD; Hao, YY; He, YT; Yu, RX; Zhang, C, 2023)
"Melasma is a common acquired circumscribed hyper-pigmentary disorder involving sun-exposed areas, particularly face."1.72Combination of autologous platelet rich plasma and hydroquinone 4% is more effective than hydroquinone alone in treatment of melasma: A split-face comparative study. ( Belgaumkar, VA; Tekam, PS, 2022)
"Melasma is an acquired disorder of facial pigmentation which is a treatment challenge."1.56Melasma: A critical analysis of clinical trials investigating treatment modalities published in the past 10 years. ( Spierings, NMK, 2020)
"Melasma is a highly prevalent hyperpigmentation disorder with a high relapsing rate and a negative impact on the psychological state of the affected patients."1.51Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study. ( Gamal, N; Ibrahim, AM; Nofal, A; Nofal, E; Osman, S, 2019)
"Melasma is an acquired, facial hyperpigmentation without a specific origin."1.51Detection of hydroquinone by Raman spectroscopy in patients with melasma before and after treatment. ( Cabrera-Alonso, R; González, FJ; Guevara, E; Moncada, B; Ramírez-Elías, MG, 2019)
"Mefenamic acid was used as an internal standard (I."1.51A New HPLC-DAD Method for the Concurrent Determination of Hydroquinone, Hydrocortisone Acetate and Tretinoin in Different Pharmaceuticals for Melasma Treatment. ( El-Deen, AK; Ibrahim, F; Sharaf El-Din, MK; Shimizu, K, 2019)
"In all, 25 patients completing the study per protocol were treated daily for 24 weeks (cohort A); 6 patients were treated daily for 12 weeks followed by 12 weeks of maintenance therapy (cohort B); and 21 patients were treated daily for 12 weeks, relapsed during the maintenance phase, and returned to daily dosing (cohort C)."1.36Continuous therapy followed by a maintenance therapy regimen with a triple combination cream for melasma. ( Bhawan, J; Colón, LE; Gottschalk, RW; Grimes, PE; Guevara, IL; Johnson, LA; Pandya, AG, 2010)
" The principal adverse effects of its chronic use are confetti-like depigmentation and exogenous ochronosis."1.35Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy. ( Azulay-Abulafia, L; Barcaui, CB; Charlín, R; Kac, BK; Rabello-Fonseca, R; Soares, DB, 2008)
"A classification of melasma is based on Wood's light examination, classifying it in four major clinical types and patterns: epidermal, dermal, mixed, and indeterminate."1.34Therapeutical approaches in melasma. ( Buggiani, G; Lotti, T; Ortonne, JP; Prignano, F, 2007)
"Melasma is a common disorder of hyperpigmentation typically characterized by relatively symmetric brown or gray-brown patches on sun-exposed facial areas."1.34An efficacy study of 3 commercially available hydroquinone 4% treatments for melasma. ( Grimes, PE, 2007)
"Cutaneous pseudolymphoma is an aggregate of mature or abnormal looking lymphocytes in the dermis, which clinically and /or histologically simulates lymphoma but has a benign course and outcome."1.33Cutaneous pseudolymphoma due to topical application of 4% hydroquinone cream for melasma. ( Dar, NR; Mustafvi, SA; Raza, N, 2005)
"The kojic acid preparation was more irritating."1.29The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions. ( Fulton, JE; Garcia, A, 1996)

Research

Studies (133)

TimeframeStudies, this research(%)All Research%
pre-19905 (3.76)18.7374
1990's9 (6.77)18.2507
2000's34 (25.56)29.6817
2010's60 (45.11)24.3611
2020's25 (18.80)2.80

Authors

AuthorsStudies
Makino, ET1
Jiang, LI2
Stephens, TJ1
Mikati, M1
Mehta, RC1
Tekam, PS1
Belgaumkar, VA1
Manuskiatti, W1
Yan, C1
Gulfan, MCB1
Techapichetvanich, T1
Wanitphakdeedecha, R1
Wattanakrai, P3
Nimmannitya, K2
Chang, YF1
Lee, TL1
Oyerinde, O1
Desai, SR1
Aljabban, A1
Bay, CP1
Bain, PA1
Chung, HJ1
Konisky, H1
Balazic, E1
Jaller, JA1
Khanna, U1
Kobets, K1
He, YT1
Hao, YY1
Yu, RX1
Zhang, C1
Chen, BZ1
Cui, Y1
Guo, XD1
Wang, J1
Fabi, S2
Robinson, D1
Bajaj, S1
Geronemus, R1
Bell, M1
Widgerow, A1
Yousefi, M1
Hadian, K1
Babossalam, S1
Diab, R1
Akhlaghi, M1
Aghighi, M1
Abdollahimajd, F1
Shokri, B1
da Silva, ACC1
Ribeiro, MM1
de Souza da Costa, N1
Galiciolli, MEA1
Souza, JV1
Irioda, AC1
Oliveira, CS1
Lin, C1
Zhu, X1
Sadick, N1
Pannu, S1
Abidi, Z1
Arruda, S1
Wang, YJ1
Lin, ET1
Chen, YT1
Chiu, PC1
Lin, BS1
Chiang, HM1
Huang, YH1
Wang, KY1
Lin, HY1
Chang, TM1
Chang, CC1
Banavase Channakeshavaiah, R1
Andanooru Chandrappa, NK1
Spierings, NMK1
Bronzina, E1
Clement, A1
Marie, B1
Fook Chong, KT1
Faure, P1
Passeron, T3
Ma, Y1
Millette, D1
Nalluri, R1
Yoo, J1
Shihab, N1
Prihartono, J1
Tovar-Garza, A1
Agustin, T1
Legiawati, L1
Pandya, AG8
Arreola Jauregui, IE1
Huerta Rivera, G1
Soria Orozco, M1
Meyer-Nava, S1
Paniagua Santos, JE1
López Zaldo, JB1
Meyer-Nava, I1
Madrid Carrillo, C1
Zaldo Rolón, IE1
Baeza Echeverría, AE1
Vázquez Huerta, M1
Ramírez-Oliveros, JF1
de Abreu, L1
Tamler, C1
Vilhena, P1
de Barros, MH1
Mohamed, EM1
Younes, AH1
Hussein, GM1
Sahu, PJ1
Singh, AL1
Kulkarni, S1
Madke, B1
Saoji, V1
Jawade, S1
Nguyen, J1
Remyn, L1
Chung, IY1
Honigman, A1
Gourani-Tehrani, S1
Wutami, I1
Wong, C1
Paul, E1
Rodrigues, M2
Kaufman, BP1
Alexis, AF1
Choi, YJ1
Nam, JH1
Kim, JY1
Min, JH1
Park, KY1
Ko, EJ1
Kim, BJ1
Kim, WS2
Chalermchai, T1
Rummaneethorn, P1
Saki, N1
Darayesh, M1
Heiran, A1
Vanaman Wilson, MJ1
Jones, IT1
Bolton, J1
Larsen, L1
Fabi, SG2
Cabrera-Alonso, R1
Guevara, E1
Ramírez-Elías, MG2
Moncada, B3
González, FJ2
Taghavi, F1
Banihashemi, M2
Zabolinejad, N2
Salehi, M2
Jaafari, MR2
Marhamati, H1
Golnouri, F1
Dorri, M1
Nofal, A1
Ibrahim, AM1
Nofal, E1
Gamal, N1
Osman, S1
Feng, C1
Yan, M1
Arrowitz, C1
Schoelermann, AM1
Mann, T1
Weber, T1
Kolbe, L1
Zubair, R1
Lyons, AB1
Vellaichamy, G1
Peacock, A1
Hamzavi, I1
Pekmezci, E1
Ibrahim, F1
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El-Deen, AK1
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Gheisari, M1
Dadkhahfar, S1
Olamaei, E1
Moghimi, HR1
Niknejad, N1
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Dreher, F2
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Gold, MH2
Goldman, MP3
Puissegur Lupo, ML1
Grimes, P3
Watson, J1
Monheit, GD1
Iida, S1
Takushima, A1
Ohura, N1
Sato, S1
Kurita, M1
Harii, K1
Chaudhary, S1
Dayal, S1
Thornfeldt, C1
Rizer, RL1
Trookman, NS1
Liu, WC1
Tey, HL1
Lee, JS1
Goh, BK1
Hexsel, D4
Soirefmann, M1
Fernandes, JD1
Siega, C1
Hsieh, PW2
Aljuffali, IA1
Fang, CL1
Chang, SH1
Fang, JY2
Mendoza, CG1
Singzon, IA1
Handog, EB1
Hammami Ghorbel, H1
Boukari, F1
Fontas, E2
Montaudié, H1
Bahadoran, P2
Lacour, JP2
Ibrahim, ZA1
Gheida, SF1
El Maghraby, GM1
Farag, ZE1
Gong, Z1
Lai, W1
Zhao, G1
Wang, X1
Zheng, M1
Li, L1
Yang, Q1
Dang, Y1
Liu, L1
Zou, Y1
Jabari, A1
Castillo-Martínez, C1
Arenas, E1
León-Bejarano, F1
Adalatkhah, H1
Sadeghi-Bazargani, H1
Eshghi, G1
Khezrian, L1
Esna Ashari, F1
Sarkar, R3
Garg, V1
Bansal, S1
Sethi, S1
Gupta, C1
Rendon, M2
Dryer, L1
Sofen, B1
Prado, G1
Emer, J1
Kwon, SH1
Hwang, YJ1
Lee, SK1
Park, KC2
Kwon, HH1
Ohn, J1
Suh, DH1
Park, HY1
Choi, SC1
Jung, JY1
Kwon, IH1
Park, GH1
Lajevardi, V1
Ghayoumi, A1
Abedini, R1
Hosseini, H1
Goodarzi, A1
Akbari, Z1
Hedayat, K1
Rendon, MI1
Barkovic, S1
Córdova, ME1
Pérez-Rojas, DO1
López-Marquet, AD1
Arenas, R1
Hung, CF1
Lin, CH1
Huang, CW1
Chan, R1
Lee, MH1
Lee, ES1
Chang, SE1
Leow, YH1
Tay, YK1
Legarda-Montinola, F1
Tsai, RY1
Tsai, TH1
Shek, S1
Kerrouche, N1
Thomas, G1
Verallo-Rowell, V1
Merola, JF1
Meehan, S1
Walters, RF1
Brown, L1
Cardona, LM1
Bussear, EW1
Benitez, AL1
Colón, LE4
Johnson, LA4
Salem, A1
Gamil, H1
Ramadan, A1
Harras, M1
Amer, A1
Grimes, PE5
Cestari, T3
Arellano, I2
Ortonne, JP3
Bhawan, J2
Keady, M1
Byers, HR1
Guevara, IL6
Gottschalk, R1
Alikhan, A1
Daly, M1
Wu, J1
Balkrishnan, R1
Feldman, SR3
Werlinger, KD1
Mornchan, R1
Eimpunth, S1
Ardigo, M1
Cameli, N1
Berardesca, E1
Gonzalez, S1
Jeong, SY1
Shin, JB1
Yeo, UC1
Kim, IH1
Gottschalk, RW2
Zawar, V1
Chuh, A1
Kodali, S1
Carrigan, CR1
Daulat, S1
Blanco, G1
Boker, A1
Hynan, LS1
Kroon, MW1
Wind, BS1
Beek, JF1
van der Veen, JP1
Nieuweboer-Krobotová, L1
Bos, JD1
Wolkerstorfer, A1
Pratchyapruit, W1
Vashrangsi, N1
Sindhavananda, J1
Tagami, H1
Palm, MD1
Preston, N1
Godse, KV1
Sakhia, J1
Ocampo-Candiani, J1
Azulay-Abulafia, L2
Bezerra Trindade Neto, P1
Machado-Pinto, J1
Muñoz, H1
Rivitti-Machado, MC1
Sittart, JA1
Trindade de Almeida, AR1
Rego, V1
Paliargues, F1
Marques-Hassun, K1
Rossi, AM1
Perez, MI1
Kang, HY1
Farshi, S1
Situm, M1
Kolić, M1
Bolanca, Z1
Ljubicić, I1
Misanović, B1
Kauvar, AN1
Mishra, SN1
Dhurat, RS1
Deshpande, DJ1
Nayak, CS1
Tourlaki, A1
Galimberti, MG1
Pellacani, G1
Bencini, PL1
Zaleski, L1
Kaur, C1
Bhalla, M1
Kanwar, AJ1
Haddad, AL1
Matos, LF1
Brunstein, F1
Ferreira, LM1
Silva, A1
Costa, D1
Gupta, AK2
Ryder, JE1
ZAMITH, VA1
FISHER, AA1
Nanda, S1
Grover, C1
Reddy, BS1
Espinal-Perez, LE1
Castanedo-Cazares, JP1
Cayce, KA1
McMichael, AJ1
Torok, HM2
Jones, T1
Rich, P1
Smith, S1
Tschen, E1
Astaneh, R1
Farboud, E1
Nazemi, MJ1
Dar, NR1
Mustafvi, SA1
Raza, N1
Kelly, AP1
Torok, H1
Willis, I1
Yoshimura, K1
Sato, K1
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Matsumoto, D1
Machino, C1
Nagase, T1
Gonda, K1
Koshima, I1
Stanfield, JW1
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Lynde, CB1
Kraft, JN1
Lynde, CW1
Gover, MD1
Nouri, K1
Taylor, S1
Cestari, TF1
Viegas, ML1
Azulay, L1
Hassun, K2
Almeida, AR1
Rêgo, VR1
Mendes, AM1
Filho, JW1
Junqueira, H1
Ferreira Cestari, T1
Sittart, A1
de Lourdes Viegas, M1
Adjadj, L1
Hux, M1
Shimizu, MR1
Rives, VP1
Prignano, F1
Buggiani, G1
Lotti, T1
Picardo, M1
Carrera, M1
Charlín, R1
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Kac, BK1
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Garg, VK1
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Goh, CL1
Yi, K1
Hart, LL1
Menke, HE1
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Garcia, A1
Fulton, JE1
Lim, JT2
Tham, SN1
Kang, WH1
Chun, SC1
Lee, S1
Kimura, T1
Doi, K1
Kauh, YC1
Zachian, TF1
Verallo-Rowell, VM1
Verallo, V1
Graupe, K1
Lopez-Villafuerte, L1
Garcia-Lopez, M1
Melli, MC1
Pathak, MA1
Fitzpatrick, TB1
Kraus, EW1

Clinical Trials (16)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Using Combination of 755-nm Picosecond Alexandrite Laser and 2% Hydroquinone Compared With 2% Hydroquinone Alone for the Treatment of Melasma: a Randomized Split-face Controlled Trial[NCT04597203]20 participants (Anticipated)Interventional2020-10-31Recruiting
Efficacy and Safety of Topical Cysteamine for Postinflammatory Hyperpigmentation: A Randomized Control, Double Blinded-trial[NCT05206318]40 participants (Anticipated)Interventional2021-12-10Recruiting
OneDoc Picopulse™ for the Treatment of Melasma Among Malaysian Women[NCT04834167]32 participants (Actual)Interventional2021-05-01Completed
Comparing Tranexamic Acid Microinjection Alone Versus Its Combination With Fractional Carbon Dioxide Laser in Melasma Treatment[NCT03899233]Phase 425 participants (Anticipated)Interventional2019-04-01Not yet recruiting
Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma[NCT03982849]Phase 292 participants (Actual)Interventional2019-07-15Completed
Topical Silymarin Versus Combined Topical Silymarin and Microneedling in Treatment of Melasma: Split Face Study[NCT05099601]Phase 430 participants (Anticipated)Interventional2022-05-31Not yet recruiting
Comparative Study of Dual Yellow Laser Versus Stabilized Kilnman Preparation in the Treatment of Melasma[NCT01850186]20 participants (Actual)Interventional2012-02-29Completed
An Assessment of the Atrophogenic Potential of Triple Combination Cream Using Histology Measures in the Treatment of Moderate to Severe Melasma[NCT00469183]Phase 470 participants (Actual)Interventional2006-05-31Completed
Comparing the Efficacy and Safety of Combined Glycolic Acid and Salicylic Acid Peel Versus Glycolic Acid Peel Alone in the Treatment of Melasma: A Split Face Study[NCT02812719]Early Phase 10 participants (Actual)Interventional2018-07-31Withdrawn (stopped due to Study did not receive funding and will not be implemented.)
Efficacy and Tolerability of an Isobutylamido-thiazolyl-resorcinol Cream 0.2% for Facial Hyperpigmentation, A Randomized Double-blind and Vehicle-Controlled Study[NCT03926845]200 participants (Actual)Interventional2019-04-29Completed
Inflammation in Melasma: Study of Its Infiltrate and the Expression of Acute and Chronic Mediators[NCT01952379]20 participants (Actual)Observational2013-07-31Completed
Double Blind Randomized Study of 2% Miconazol Versus 4% Hydroquinone in the Treatment for Melasma.[NCT01661556]Phase 460 participants (Anticipated)Interventional2011-10-31Recruiting
A Double Blind Randomized Study Comparing the Ultraviolet (UV) Photoprotection With UV Plus Visible Light Photoprotection in the Treatment of Melasma.[NCT01695356]Phase 468 participants (Actual)Interventional2012-09-30Completed
Solar Lentigines Treatment With the Triple Combination Cream (Hydroquinone 4%, Tretinoin 0.05%, and Fluocinolone Acetonide 0.01%). Randomized, Double Blind, Controlled Trial.[NCT00975312]Phase 222 participants (Actual)Interventional2008-08-31Completed
The Efficacy of Combined Peels in Treatment of Melasma Using Modified Jessner's Solution With 20%Trichloroacetic Acid Versus 70%Glycolic Acid With 20% Trichloroacetic Acid : A Split-face Study[NCT03153852]Phase 430 participants (Anticipated)Interventional2018-03-15Not yet recruiting
Evaluation of the Therapeutic Effect of Platelet Rich Plasma in Melasma[NCT03308370]Phase 326 participants (Anticipated)Interventional2017-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

17 reviews available for hydroquinone and Chloasma

ArticleYear
Efficacy and safety of topical agents in the treatment of melasma: What's evidence? A systematic review and meta-analysis.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:4

    Topics: Cysteamine; Humans; Melanosis; Tranexamic Acid; Treatment Outcome; Zinc Sulfate

2023
Tranexamic acid in melasma: A focused review on drug administration routes.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:4

    Topics: Administration, Topical; Adult; Female; Humans; Hydroquinones; Melanosis; Tranexamic Acid; Treatment

2023
What's New in Pigmentary Disorders.
    Dermatologic clinics, 2019, Volume: 37, Issue:2

    Topics: alpha-MSH; Antifibrinolytic Agents; Bimatoprost; Dermatologic Agents; Humans; Hydroquinones; Inflamm

2019
Melasma: clinical diagnosis and management options.
    The Australasian journal of dermatology, 2015, Volume: 56, Issue:3

    Topics: Administration, Cutaneous; Antioxidants; Chemexfoliation; Cosmetics; Drug Combinations; Humans; Hydr

2015
Melasma and Post Inflammatory Hyperpigmentation: Management Update and Expert Opinion.
    Skin therapy letter, 2016, Volume: 21, Issue:1

    Topics: Dermatologic Agents; Humans; Hydroquinones; Hyperpigmentation; Inflammation; Melanosis; Phototherapy

2016
Heterogeneous Pathology of Melasma and Its Clinical Implications.
    International journal of molecular sciences, 2016, May-26, Volume: 17, Issue:6

    Topics: Administration, Topical; Antioxidants; Basement Membrane; Chloroquine; Dermis; Disease Management; G

2016
Management of hyperpigmentation in darker racial ethnic groups.
    Seminars in cutaneous medicine and surgery, 2009, Volume: 28, Issue:2

    Topics: Antioxidants; Chemexfoliation; Dermabrasion; Humans; Hydroquinones; Hyperpigmentation; Laser Therapy

2009
Melasma in Latin America: options for therapy and treatment algorithm.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2009, Volume: 23, Issue:7

    Topics: Algorithms; Drug Therapy, Combination; Evidence-Based Medicine; Fluocinolone Acetonide; Humans; Hydr

2009
Melasma--updated treatments.
    Collegium antropologicum, 2011, Volume: 35 Suppl 2

    Topics: Adrenal Cortex Hormones; Female; Humans; Hydroquinones; Keratolytic Agents; Male; Melanosis; Photoch

2011
Treatment of melasma and the use of intense pulsed light: a review.
    Journal of drugs in dermatology : JDD, 2012, Volume: 11, Issue:11

    Topics: Administration, Cutaneous; Adult; Combined Modality Therapy; Dermatologic Agents; Face; Female; Foll

2012
Hyperpigmentation: an overview of the common afflictions.
    Dermatology nursing, 2004, Volume: 16, Issue:5

    Topics: Chemexfoliation; Cryotherapy; Dermatologic Agents; Dicarboxylic Acids; Humans; Hydroquinones; Hyperp

2004
A comprehensive review of the long-term and short-term treatment of melasma with a triple combination cream.
    American journal of clinical dermatology, 2006, Volume: 7, Issue:4

    Topics: Administration, Cutaneous; Fluocinolone Acetonide; Glucocorticoids; Humans; Hydroquinones; Keratolyt

2006
Topical treatments for melasma and postinflammatory hyperpigmentation.
    Skin therapy letter, 2006, Volume: 11, Issue:9

    Topics: Administration, Topical; Dermatologic Agents; Female; Humans; Hydroquinones; Hyperpigmentation; Infl

2006
The treatment of melasma: a review of clinical trials.
    Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy

2006
The treatment of melasma: a review of clinical trials.
    Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy

2006
The treatment of melasma: a review of clinical trials.
    Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy

2006
The treatment of melasma: a review of clinical trials.
    Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy

2006
New and experimental treatments of cloasma and other hypermelanoses.
    Dermatologic clinics, 2007, Volume: 25, Issue:3

    Topics: Chemexfoliation; Dermatologic Agents; Drug Combinations; Flavonoids; Glucocorticoids; Humans; Hydroq

2007
Hydroquinone-induced exogenous ochronosis in Chinese--two case reports and a review.
    International journal of dermatology, 2008, Volume: 47, Issue:6

    Topics: Administration, Cutaneous; Asian People; Dermatologic Agents; Female; Humans; Hydroquinones; Melanos

2008
Melasma. Etiologic and therapeutic considerations.
    Archives of dermatology, 1995, Volume: 131, Issue:12

    Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans;

1995
Melasma. Etiologic and therapeutic considerations.
    Archives of dermatology, 1995, Volume: 131, Issue:12

    Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans;

1995
Melasma. Etiologic and therapeutic considerations.
    Archives of dermatology, 1995, Volume: 131, Issue:12

    Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans;

1995
Melasma. Etiologic and therapeutic considerations.
    Archives of dermatology, 1995, Volume: 131, Issue:12

    Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans;

1995

Trials

67 trials available for hydroquinone and Chloasma

ArticleYear
Combination of a 755-nm picosecond laser and hydroquinone 2% cream versus hydroquinone 2% cream alone for the treatment of melasma: A randomized, split-face, and controlled trial.
    Lasers in surgery and medicine, 2022, Volume: 54, Issue:10

    Topics: Humans; Hydroquinones; Lasers, Solid-State; Melanins; Melanosis; Treatment Outcome

2022
A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
    Journal of drugs in dermatology : JDD, 2022, Dec-01, Volume: 21, Issue:12

    Topics: Double-Blind Method; Humans; Hydroquinones; Melanosis; Silymarin; Treatment Outcome

2022
A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
    Journal of drugs in dermatology : JDD, 2022, Dec-01, Volume: 21, Issue:12

    Topics: Double-Blind Method; Humans; Hydroquinones; Melanosis; Silymarin; Treatment Outcome

2022
A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
    Journal of drugs in dermatology : JDD, 2022, Dec-01, Volume: 21, Issue:12

    Topics: Double-Blind Method; Humans; Hydroquinones; Melanosis; Silymarin; Treatment Outcome

2022
A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
    Journal of drugs in dermatology : JDD, 2022, Dec-01, Volume: 21, Issue:12

    Topics: Double-Blind Method; Humans; Hydroquinones; Melanosis; Silymarin; Treatment Outcome

2022
A Multi-Center, Randomized, Blinded Clinical Study Evaluating the Efficacy and Safety of a Novel Topical Product for Facial Dyschromia.
    Journal of drugs in dermatology : JDD, 2023, Apr-01, Volume: 22, Issue:4

    Topics: Administration, Cutaneous; Dermatologic Agents; Humans; Hydroquinones; Hyperpigmentation; Melanosis;

2023
Split-face comparison of hydroquinone 4% plus nitrogen plasma vs. hydroquinone 4% alone in the treatment of melasma.
    Lasers in medical science, 2023, Apr-27, Volume: 38, Issue:1

    Topics: Female; Humans; Hydroquinones; Melanins; Melanosis; Treatment Outcome

2023
Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2020, Volume: 34, Issue:3

    Topics: Adult; Asian People; Combined Modality Therapy; Drug Combinations; Female; Fluocinolone Acetonide; H

2020
Topical metformin in the treatment of melasma: A preliminary clinical trial.
    Journal of cosmetic dermatology, 2020, Volume: 19, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Drug Combinations; Female; Fluocinolone Acetonide; Humans; Hydroquin

2020
Efficacy and tolerability on melasma of a topical cosmetic product acting on melanocytes, fibroblasts and endothelial cells: a randomized comparative trial against 4% hydroquinone.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2020, Volume: 34, Issue:4

    Topics: Administration, Topical; Adult; Cosmetics; Double-Blind Method; Endothelial Cells; Female; Fibroblas

2020
Randomised, controlled, double-blind study of combination therapy of oral tranexamic acid and topical hydroquinone in the treatment of melasma.
    The Australasian journal of dermatology, 2020, Volume: 61, Issue:3

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Antifibrinolytic Agents; Double-Blind Method

2020
Efficacy of 577 nm pro-yellow laser in the treatment of melasma: a prospective split-face study.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2020, Feb-17, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Combined Modality Therapy; Female; Humans; Hydroquinones; Lasers, Solid-State; Lo

2020
Study of oral tranexamic acid, topical tranexamic acid, and modified Kligman's regimen in treatment of melasma.
    Journal of cosmetic dermatology, 2020, Volume: 19, Issue:6

    Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Drug Combinations; Female; Fluoc

2020
Evaluation of the efficacy of cysteamine cream compared to hydroquinone in the treatment of melasma: A randomised, double-blinded trial.
    The Australasian journal of dermatology, 2021, Volume: 62, Issue:1

    Topics: Administration, Topical; Adult; Cysteamine; Dermatologic Agents; Double-Blind Method; Female; Humans

2021
Randomized, Double-Blinded, Split-Face Study Comparing the Efficacy and Tolerability of Two Topical Products for Melasma.
    Journal of drugs in dermatology : JDD, 2020, Sep-01, Volume: 19, Issue:9

    Topics: Adult; Aged; Dermatologic Agents; Face; Female; Humans; Hydroquinones; Male; Melanosis; Middle Aged;

2020
Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split-face, 2% hydroquinone cream-controlled clinical trial.
    Lasers in surgery and medicine, 2017, Volume: 49, Issue:10

    Topics: Administration, Cutaneous; Adult; Aged; Combined Modality Therapy; Enzyme Inhibitors; Female; Follow

2017
Effects of a fractional picosecond 1,064 nm laser for the treatment of dermal and mixed type melasma.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2018, Volume: 20, Issue:3

    Topics: Adult; Erythema; Female; Humans; Hydroquinones; Lasers, Solid-State; Low-Level Light Therapy; Melano

2018
Comparing the efficacy of topical hydroquinone 2% versus intradermal tranexamic acid microinjections in treating melasma: a split-face controlled trial.
    The Journal of dermatological treatment, 2018, Volume: 29, Issue:4

    Topics: Administration, Topical; Adult; Erythema; Face; Female; Humans; Hydroquinones; Melanins; Melanosis;

2018
The Safety and Efficacy of Treatment With a 1,927-nm Diode Laser With and Without Topical Hydroquinone for Facial Hyperpigmentation and Melasma in Darker Skin Types.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2018, Volume: 44, Issue:10

    Topics: Administration, Cutaneous; Adult; Aged; Antioxidants; Face; Female; Humans; Hydroquinones; Hyperpigm

2018
Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma.
    Journal of cosmetic dermatology, 2019, Volume: 18, Issue:3

    Topics: Administration, Cutaneous; Adult; Double-Blind Method; Face; Female; Humans; Hydroquinones; Liposome

2019
Clinical observation on tranexamic acid combined with reduced glutathione for the treatment of chloasma.
    Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:6(Special)

    Topics: Administration, Cutaneous; Adult; Drug Therapy, Combination; Female; Glutathione; Humans; Hydroquino

2018
Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:8

    Topics: Administration, Cutaneous; Adult; Aged; Double-Blind Method; Face; Female; Humans; Hydroquinones; Me

2019
The efficacy and safety of topical 5% methimazole vs 4% hydroquinone in the treatment of melasma: A randomized controlled trial.
    Journal of cosmetic dermatology, 2020, Volume: 19, Issue:1

    Topics: Adult; Double-Blind Method; Female; Humans; Hydroquinones; Melanosis; Methimazole; Middle Aged; Pati

2020
Treating epidermal melasma with a 4% hydroquinone skin care system plus tretinoin cream 0.025%.
    Cutis, 2013, Volume: 91, Issue:1

    Topics: Administration, Cutaneous; Antioxidants; Drug Therapy, Combination; Female; Humans; Hydroquinones; K

2013
Comparison of a skin-lightening cream targeting melanogenesis on multiple levels to triple combination cream for melasma.
    Journal of drugs in dermatology : JDD, 2013, Volume: 12, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Dermatologic Agents; Drug Combinations; Female;

2013
Efficacy of combination of glycolic acid peeling with topical regimen in treatment of melasma.
    Journal of drugs in dermatology : JDD, 2013, Volume: 12, Issue:10

    Topics: Adult; Anti-Inflammatory Agents; Antioxidants; Chemexfoliation; Female; Glycolates; Humans; Hydrocor

2013
Objective assessment of erythema and pigmentation of melasma lesions and surrounding areas in long-term management regimens with triple combination.
    Journal of drugs in dermatology : JDD, 2014, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antioxidants; Drug Therapy, Combination; Erythema; Fluo

2014
A randomized, double-blind, placebo-controlled clinical trial on the efficacy and safety of 3% Rumex occidentalis cream versus 4% hydroquinone cream in the treatment of melasma among Filipinos.
    International journal of dermatology, 2014, Volume: 53, Issue:11

    Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Hydroquinones; Male; Melanosis; Middle Aged;

2014
Copper Bromide Laser vs Triple-Combination Cream for the Treatment of Melasma: A Randomized Clinical Trial.
    JAMA dermatology, 2015, Volume: 151, Issue:7

    Topics: Adult; Bromides; Copper; Dexamethasone; Drug Combinations; Female; Humans; Hydroquinones; Laser Ther

2015
Efficacy and safety of fluocinolone acetonide, hydroquinone, and tretinoin cream in chinese patients with melasma: a randomized, double-blind, placebo-controlled, multicenter, parallel-group study.
    Clinical drug investigation, 2015, Volume: 35, Issue:6

    Topics: Adolescent; Adult; Asian People; Double-Blind Method; Female; Fluocinolone Acetonide; Humans; Hydroq

2015
Comparison of therapeutic effects of liposomal Tranexamic Acid and conventional Hydroquinone on melasma.
    Journal of cosmetic dermatology, 2015, Volume: 14, Issue:3

    Topics: Adult; Dermatologic Agents; Double-Blind Method; Female; Humans; Hydroquinones; Liposomes; Melanosis

2015
Raman spectroscopy analysis of the skin of patients with melasma before standard treatment with topical corticosteroids, retinoic acid, and hydroquinone mixture.
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2016, Volume: 22, Issue:2

    Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Dermatologic Ag

2016
The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Administration, Cutaneous; Adult; Double-Blind Method; Female; Flutamide; Humans; Hydroquinones; Ira

2015
Comparison between Intralesional Triamcinolone and Kligman's Formula in Treatment of Melasma.
    Acta medica Iranica, 2016, Volume: 54, Issue:1

    Topics: Administration, Topical; Adult; Dexamethasone; Female; Humans; Hydroquinones; Melanosis; Middle Aged

2016
Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2016, Volume: 42, Issue:3

    Topics: Adult; Antioxidants; Chemexfoliation; Drug Combinations; Female; Follow-Up Studies; Glycolates; Huma

2016
Comparison of the therapeutic efficacy and safety of combined oral tranexamic acid and topical hydroquinone 4% treatment vs. topical hydroquinone 4% alone in melasma: a parallel-group, assessor- and analyst-blinded, randomized controlled trial with a shor
    Journal of cosmetic dermatology, 2017, Volume: 16, Issue:2

    Topics: Administration, Oral; Administration, Topical; Adult; Drug Therapy, Combination; Female; Follow-Up S

2017
A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma.
    The British journal of dermatology, 2008, Volume: 159, Issue:3

    Topics: Administration, Cutaneous; Adult; Analysis of Variance; Asian People; Double-Blind Method; Drug Comb

2008
Successful treatment of moderate to severe melasma with triple-combination cream and glycolic acid peels: a pilot study.
    Cutis, 2008, Volume: 82, Issue:5

    Topics: Administration, Cutaneous; Adult; Chemexfoliation; Dermatologic Agents; Drug Combinations; Drug Ther

2008
Melasma: treatment evaluation.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2009, Volume: 11, Issue:3

    Topics: Administration, Cutaneous; Caustics; Dermatologic Agents; Egypt; Female; Humans; Hydroquinones; Lase

2009
A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream.
    The American Journal of dermatopathology, 2009, Volume: 31, Issue:8

    Topics: Administration, Cutaneous; Adult; Atrophy; Dermatologic Agents; Drug Combinations; Female; Fluocinol

2009
Low-fluence Q-switched neodymium-doped yttrium aluminum garnet (1,064 nm) laser for the treatment of facial melasma in Asians.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2010, Volume: 36, Issue:1

    Topics: Administration, Topical; Adult; Asian People; Combined Modality Therapy; Dermatologic Agents; Female

2010
Characterization and evaluation of pigment distribution and response to therapy in melasma using in vivo reflectance confocal microscopy: a preliminary study.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2010, Volume: 24, Issue:11

    Topics: Adult; Drug Monitoring; Drug Therapy, Combination; Epidermis; Face; Female; Follow-Up Studies; Human

2010
Low-fluence Q-switched neodymium-doped yttrium aluminum garnet laser for melasma with pre- or post-treatment triple combination cream.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2010, Volume: 36, Issue:6

    Topics: Administration, Topical; Adult; Antioxidants; Combined Modality Therapy; Cross-Over Studies; Drug Ad

2010
A prospective, randomized, split-face, controlled trial of salicylic acid peels in the treatment of melasma in Latin American women.
    Journal of the American Academy of Dermatology, 2010, Volume: 63, Issue:6

    Topics: Adult; Chemexfoliation; Female; Hispanic or Latino; Humans; Hydroquinones; Keratolytic Agents; Melan

2010
Nonablative 1550-nm fractional laser therapy versus triple topical therapy for the treatment of melasma: a randomized controlled pilot study.
    Journal of the American Academy of Dermatology, 2011, Volume: 64, Issue:3

    Topics: Administration, Topical; Adult; Female; Humans; Hydroquinones; Laser Therapy; Melanosis; Middle Aged

2011
Instrumental analysis of the pattern of improvement and that of recurrence of melasma in Thai females treated with Kligman-Willis triple combination therapy: confirmation by using its two different formulae.
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2011, Volume: 17, Issue:2

    Topics: Administration, Topical; Adrenal Cortex Hormones; Adult; Asian People; Chemistry, Pharmaceutical; Dr

2011
Sequential treatment with triple combination cream and intense pulsed light is more efficacious than sequential treatment with an inactive (control) cream and intense pulsed light in patients with moderate to severe melasma.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2011, Volume: 37, Issue:2

    Topics: Adult; Aged; Anti-Inflammatory Agents; Combined Modality Therapy; Female; Fluocinolone Acetonide; Hu

2011
Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2012, Volume: 26, Issue:5

    Topics: Dermatologic Agents; Drug Therapy, Combination; Fluocinolone Acetonide; Humans; Hydroquinones; Melan

2012
Melasma treatment with pulsed-dye laser and triple combination cream: a prospective, randomized, single-blind, split-face study.
    Archives of dermatology, 2011, Volume: 147, Issue:9

    Topics: Adult; Bleaching Agents; Dermatologic Agents; Drug Combinations; Female; Fluocinolone Acetonide; Glu

2011
Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma.
    Journal of cosmetic dermatology, 2011, Volume: 10, Issue:4

    Topics: Adult; Antioxidants; Dermatologic Agents; Dicarboxylic Acids; Emollients; Female; Humans; Hydroquino

2011
Successful treatment of melasma using a combination of microdermabrasion and Q-switched Nd:YAG lasers.
    Lasers in surgery and medicine, 2012, Volume: 44, Issue:2

    Topics: Adult; Antioxidants; Ascorbic Acid; Combined Modality Therapy; Dermabrasion; Female; Follow-Up Studi

2012
Combination of fractional erbium-glass laser and topical therapy in melasma resistant to triple-combination cream.
    The Journal of dermatological treatment, 2014, Volume: 25, Issue:3

    Topics: Adult; Combined Modality Therapy; Dermatologic Agents; Female; Humans; Hydrocortisone; Hydroquinones

2014
The combination of glycolic acid peels with a topical regimen in the treatment of melasma in dark-skinned patients: a comparative study.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2002, Volume: 28, Issue:9

    Topics: Administration, Topical; Adult; Chemexfoliation; Drug Combinations; Female; Glycolates; Humans; Hydr

2002
A clinical, prospective, randomized, double-blind trial comparing skin whitening complex with hydroquinone vs. placebo in the treatment of melasma.
    International journal of dermatology, 2003, Volume: 42, Issue:2

    Topics: Adult; Dermatologic Agents; Double-Blind Method; Drug Eruptions; Humans; Hydroquinones; Melanosis; M

2003
Safety and efficacy of 4% hydroquinone combined with 10% glycolic acid, antioxidants, and sunscreen in the treatment of melasma.
    International journal of dermatology, 2003, Volume: 42, Issue:12

    Topics: Administration, Cutaneous; Adult; Ascorbic Acid; Drug Therapy, Combination; Female; Glycolates; Huma

2003
Efficacy of hydroquinone (2%) versus tretinoin (0.025%) as adjunct topical agents for chemical peeling in patients of melasma.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2004, Volume: 30, Issue:3

    Topics: Administration, Topical; Adolescent; Adult; Chemexfoliation; Double-Blind Method; Female; Humans; Hy

2004
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
    International journal of dermatology, 2004, Volume: 43, Issue:8

    Topics: Administration, Topical; Adult; Ascorbic Acid; Dermatologic Agents; Double-Blind Method; Female; Hum

2004
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
    International journal of dermatology, 2004, Volume: 43, Issue:8

    Topics: Administration, Topical; Adult; Ascorbic Acid; Dermatologic Agents; Double-Blind Method; Female; Hum

2004
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
    International journal of dermatology, 2004, Volume: 43, Issue:8

    Topics: Administration, Topical; Adult; Ascorbic Acid; Dermatologic Agents; Double-Blind Method; Female; Hum

2004
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
    International journal of dermatology, 2004, Volume: 43, Issue:8

    Topics: Administration, Topical; Adult; Ascorbic Acid; Dermatologic Agents; Double-Blind Method; Female; Hum

2004
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
    International journal of dermatology, 2004, Volume: 43, Issue:8

    Topics: Administration, Topical; Adult; Ascorbic Acid; Dermatologic Agents; Double-Blind Method; Female; Hum

2004
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
    International journal of dermatology, 2004, Volume: 43, Issue:8

    Topics: Administration, Topical; Adult; Ascorbic Acid; Dermatologic Agents; Double-Blind Method; Female; Hum

2004
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
    International journal of dermatology, 2004, Volume: 43, Issue:8

    Topics: Administration, Topical; Adult; Ascorbic Acid; Dermatologic Agents; Double-Blind Method; Female; Hum

2004
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
    International journal of dermatology, 2004, Volume: 43, Issue:8

    Topics: Administration, Topical; Adult; Ascorbic Acid; Dermatologic Agents; Double-Blind Method; Female; Hum

2004
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
    International journal of dermatology, 2004, Volume: 43, Issue:8

    Topics: Administration, Topical; Adult; Ascorbic Acid; Dermatologic Agents; Double-Blind Method; Female; Hum

2004
A microsponge formulation of hydroquinone 4% and retinol 0.15% in the treatment of melasma and postinflammatory hyperpigmentation.
    Cutis, 2004, Volume: 74, Issue:6

    Topics: Administration, Topical; Adult; Dermatologic Agents; Drug Administration Schedule; Drug Combinations

2004
Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12-month treatment for melasma.
    Cutis, 2005, Volume: 75, Issue:1

    Topics: Antioxidants; Drug Combinations; Facial Dermatoses; Female; Fluocinolone Acetonide; Glucocorticoids;

2005
Community-based trial of a triple-combination agent for the treatment of facial melasma.
    Cutis, 2006, Volume: 77, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Dermato

2006
Sun protection strength of a hydroquinone 4%/retinol 0.3% preparation containing sunscreens.
    Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:4

    Topics: Administration, Cutaneous; Adult; Chalcones; Cinnamates; Dose-Response Relationship, Drug; Dose-Resp

2006
A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasma.
    Journal of cosmetic dermatology, 2007, Volume: 6, Issue:1

    Topics: Administration, Topical; Adult; Drug Combinations; Emollients; Facial Dermatoses; Female; Fluocinolo

2007
Cost-effectiveness of a fixed combination of hydroquinone/tretinoin/fluocinolone cream compared with hydroquinone alone in the treatment of melasma.
    Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:2

    Topics: Administration, Topical; Cost-Benefit Analysis; Drug Combinations; Drug Costs; Fluocinolone Acetonid

2007
Comparative evaluation of beneficiary effects of priming agents (2% hydroquinone and 0.025% retinoic acid) in the treatment of melasma with glycolic acid peels.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2008, Volume: 34, Issue:8

    Topics: Adolescent; Adult; Chemexfoliation; Female; Glycolates; Humans; Hydroquinones; Male; Melanosis; Midd

2008
Glycolic acid peels in the treatment of melasma among Asian women.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1997, Volume: 23, Issue:3

    Topics: Administration, Topical; Adult; Asian People; Chemexfoliation; China; Drug Combinations; Female; Gly

1997
Intermittent therapy for melasma in Asian patients with combined topical agents (retinoic acid, hydroquinone and hydrocortisone): clinical and histological studies.
    The Journal of dermatology, 1998, Volume: 25, Issue:9

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Asian People; Dermis; Drug Administration

1998
Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1999, Volume: 25, Issue:4

    Topics: Adult; Aspergillus oryzae; Double-Blind Method; Drug Combinations; Facial Dermatoses; Female; Gels;

1999
Melasma.
    Advances in experimental medicine and biology, 1999, Volume: 455

    Topics: Adult; Demography; Female; Humans; Hydroquinones; Keratolytic Agents; Melanosis; Middle Aged; Radiat

1999
Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma.
    Acta dermato-venereologica. Supplementum, 1989, Volume: 143

    Topics: Administration, Topical; Dicarboxylic Acids; Double-Blind Method; Drug Eruptions; Female; Humans; Hy

1989
Usefulness of retinoic acid in the treatment of melasma.
    Journal of the American Academy of Dermatology, 1986, Volume: 15, Issue:4 Pt 2

    Topics: Administration, Topical; Clinical Trials as Topic; Drug Combinations; Female; Humans; Hydroquinones;

1986

Other Studies

49 other studies available for hydroquinone and Chloasma

ArticleYear
Pigmentation control in pregnancy-induced melasma: Clinical assessment of a non-hydroquinone, non-retinol pigment-correcting serum.
    Journal of cosmetic dermatology, 2022, Volume: 21, Issue:11

    Topics: Administration, Cutaneous; Adult; Female; Humans; Hydroquinones; Hyperpigmentation; Melanosis; Pregn

2022
Combination of autologous platelet rich plasma and hydroquinone 4% is more effective than hydroquinone alone in treatment of melasma: A split-face comparative study.
    Dermatologic therapy, 2022, Volume: 35, Issue:11

    Topics: Humans; Hydroquinones; Melanosis; Platelet-Rich Plasma; Treatment Outcome

2022
Hydroquinone cream-based polymer microneedle roller for the combined treatment of large-area chloasma.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2023, Volume: 185

    Topics: Animals; Hydroquinones; Melanosis; Mice; Paraffin; Polymers; Quality of Life; Ultraviolet Rays

2023
Analysis of the antimelanogenic activity of zinc and selenium in vitro.
    Archives of dermatological research, 2023, Volume: 315, Issue:10

    Topics: Humans; Hydroquinones; Melanins; Melanosis; Selenium; Trace Elements; Zinc

2023
Efficacy of photorejuvenation combined with tranexamic acid and hydroquinone cream in the treatment of complex facial pigmentation.
    Medicine, 2023, Aug-25, Volume: 102, Issue:34

    Topics: Humans; Hydroquinones; Melanosis; Pigmentation; Retrospective Studies; Tranexamic Acid; Water

2023
Topical Treatments for Melasma and Post-inflammatory Hyperpigmentation.
    Journal of drugs in dermatology : JDD, 2023, Nov-01, Volume: 22, Issue:11

    Topics: Adult; Female; Humans; Hyperpigmentation; Melanosis; Retinoids; Skin

2023
Melasma: A critical analysis of clinical trials investigating treatment modalities published in the past 10 years.
    Journal of cosmetic dermatology, 2020, Volume: 19, Issue:6

    Topics: Administration, Cutaneous; Administration, Oral; Chemexfoliation; Clinical Trials as Topic; Combined

2020
UK-based dermatologist online survey on the current practice and training in the management of melasma and postinflammatory hyperpigmentation.
    Clinical and experimental dermatology, 2020, Volume: 45, Issue:4

    Topics: Administration, Topical; Alkaptonuria; Dermatologists; Drug Therapy, Combination; Humans; Hydroquino

2020
A cross-sectional report on melasma among Hispanic patients: Evaluating the role of oral tranexamic acid versus oral tranexamic acid plus hydroquinone.
    Journal of the American Academy of Dermatology, 2020, Volume: 83, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Cross-Sectional Studies; Drug Combinations; Female; Hispani

2020
Microneedling with Drug Delivery (Hydroquinone 4% Serum) as an Adjuvant Therapy for Recalcitrant Melasma.
    Skinmed, 2020, Volume: 18, Issue:1

    Topics: Adult; Combined Modality Therapy; Cosmetic Techniques; Dermatologic Agents; Drug Delivery Systems; F

2020
Detection of hydroquinone by Raman spectroscopy in patients with melasma before and after treatment.
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2019, Volume: 25, Issue:1

    Topics: Adult; Drug Monitoring; Drug Therapy, Combination; Female; Fluocinolone Acetonide; Humans; Hydroquin

2019
Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study.
    Journal of cosmetic dermatology, 2019, Volume: 18, Issue:1

    Topics: Administration, Cutaneous; Adult; Antioxidants; Female; Humans; Hydroquinones; Melanosis; Middle Age

2019
Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study.
    Journal of cosmetic dermatology, 2019, Volume: 18, Issue:1

    Topics: Administration, Cutaneous; Adult; Antioxidants; Female; Humans; Hydroquinones; Melanosis; Middle Age

2019
Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study.
    Journal of cosmetic dermatology, 2019, Volume: 18, Issue:1

    Topics: Administration, Cutaneous; Adult; Antioxidants; Female; Humans; Hydroquinones; Melanosis; Middle Age

2019
Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study.
    Journal of cosmetic dermatology, 2019, Volume: 18, Issue:1

    Topics: Administration, Cutaneous; Adult; Antioxidants; Female; Humans; Hydroquinones; Melanosis; Middle Age

2019
A novel triple combination in treatment of melasma: Significant outcome with far less actives.
    Journal of cosmetic dermatology, 2019, Volume: 18, Issue:6

    Topics: Administration, Cutaneous; Adult; Dermatologic Agents; Diagnostic Self Evaluation; Dicarboxylic Acid

2019
A New HPLC-DAD Method for the Concurrent Determination of Hydroquinone, Hydrocortisone Acetate and Tretinoin in Different Pharmaceuticals for Melasma Treatment.
    Journal of chromatographic science, 2019, Jul-01, Volume: 57, Issue:6

    Topics: Chromatography, High Pressure Liquid; Dermatologic Agents; Drug Combinations; Humans; Hydrocortisone

2019
Efficacy of hydroquinone-free skin-lightening cream for photoaging.
    Journal of cosmetic dermatology, 2013, Volume: 12, Issue:1

    Topics: Administration, Cutaneous; Adult; Aged; California; Dermatologic Agents; Drug Combinations; Female;

2013
Silicone sheet containing all-trans retinoic acid and hydroquinone for the treatment of epidermal melanosis.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013, Volume: 39, Issue:8

    Topics: Adult; Aged; Antioxidants; Drug Therapy, Combination; Female; Humans; Hydroquinones; Keratolytic Age

2013
Blockade of melanin synthesis, activation and distribution pathway by a nonprescription natural regimen is equally effective to a multiple prescription-based therapeutic regimen.
    Journal of drugs in dermatology : JDD, 2013, Volume: 12, Issue:12

    Topics: Adult; Biological Products; Dermatologic Agents; Female; Follow-Up Studies; Humans; Hydroquinones; H

2013
Exogenous ochronosis in a Chinese patient: use of dermoscopy aids early diagnosis and selection of biopsy site.
    Singapore medical journal, 2014, Volume: 55, Issue:1

    Topics: Alkaptonuria; Biopsy; Bleaching Agents; China; Dermoscopy; Humans; Hydroquinones; Male; Melanosis; M

2014
Hydroquinone-salicylic acid conjugates as novel anti-melasma actives show superior skin targeting compared to the parent drugs.
    Journal of dermatological science, 2014, Volume: 76, Issue:2

    Topics: Animals; Hydrolysis; Hydroquinones; Melanosis; Mice; Molecular Docking Simulation; Monophenol Monoox

2014
Evaluation of the efficacy and safety of combinations of hydroquinone, glycolic acid, and hyaluronic acid in the treatment of melasma.
    Journal of cosmetic dermatology, 2015, Volume: 14, Issue:2

    Topics: Dermatologic Agents; Dermoscopy; Female; Glycolates; Humans; Hyaluronic Acid; Hydroquinones; Melanos

2015
Investigator-Blinded, Single-Center Study to Evaluate the Efficacy and Tolerability of a 4% Hydroquinone Skin Care System Plus 0.02% Tretinoin Cream in Mild-to-Moderate Melasma and Photodamage.
    Journal of drugs in dermatology : JDD, 2016, Volume: 15, Issue:4

    Topics: Administration, Cutaneous; Adult; Aged; Drug Compounding; Drug Therapy, Combination; Female; Humans;

2016
A pilot study for triple combination therapy with a low-fluence 1064 nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's Melanosis.
    The Journal of dermatological treatment, 2017, Volume: 28, Issue:2

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Combined Modality Therapy; Erythema; Facial

2017
Clinical Evaluation of a 4% Hydroquinone + 1% Retinol Treatment Regimen for Improving Melasma and Photodamage in Fitzpatrick Skin Types III-VI.
    Journal of drugs in dermatology : JDD, 2016, Nov-01, Volume: 15, Issue:11

    Topics: Administration, Cutaneous; Adult; Aged; Drug Compounding; Drug Therapy, Combination; Female; Humans;

2016
Exogenous Ochronosis in Facial Melasma.
    Actas dermo-sifiliograficas, 2017, Volume: 108, Issue:4

    Topics: Dermoscopy; Facial Dermatoses; Female; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Hyd

2017
Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2017, Volume: 114

    Topics: Administration, Cutaneous; Animals; Drug Combinations; Female; Hydrolysis; Hydroquinones; Interleuki

2017
Exogenous ochronosis.
    Dermatology online journal, 2008, Oct-15, Volume: 14, Issue:10

    Topics: Dermatologic Agents; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Hydroquinones; Mela

2008
Cost-effectiveness of a hydroquinone/tretinoin/fluocinolone acetonide cream combination in treating melasma in the United States.
    The Journal of dermatological treatment, 2010, Volume: 21, Issue:5

    Topics: Administration, Cutaneous; Clinical Trials as Topic; Cost-Benefit Analysis; Dermatologic Agents; Dru

2010
Tolerability and efficacy of a novel formulation in the treatment of melasma.
    Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:3

    Topics: Adult; Dermatologic Agents; Drug Therapy, Combination; Female; Glycolates; Humans; Hyaluronic Acid;

2010
Continuous therapy followed by a maintenance therapy regimen with a triple combination cream for melasma.
    Journal of the American Academy of Dermatology, 2010, Volume: 62, Issue:6

    Topics: Administration, Topical; Adolescent; Adult; Aged; Drug Administration Schedule; Drug Combinations; F

2010
Exogenous ochronosis in Asians.
    International journal of dermatology, 2010, Volume: 49, Issue:1

    Topics: Antioxidants; Asian People; Humans; Hydroquinones; Melanosis; Ochronosis; Pigmentation Disorders

2010
Triple combination and glycolic acid peels in melasma in Indian patients.
    Journal of cosmetic dermatology, 2011, Volume: 10, Issue:1

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Antioxidants; Chemexfoliation; Drug Combin

2011
Treatment of hyperpigmentation.
    Facial plastic surgery clinics of North America, 2011, Volume: 19, Issue:2

    Topics: Anisoles; Combined Modality Therapy; Dermatologic Agents; Drug Therapy, Combination; Humans; Hydroqu

2011
Diagnostic utility of dermatoscopy in hydroquinone-induced exogenous ochronosis.
    International journal of dermatology, 2013, Volume: 52, Issue:4

    Topics: Adult; Dermoscopy; Humans; Hydroquinones; Male; Melanosis; Ochronosis

2013
Lustra, Lustra-AF and Alustra.
    Skin therapy letter, 2003, Volume: 8, Issue:5

    Topics: Drug Therapy, Combination; Humans; Hydroquinones; Hyperpigmentation; Melanosis; Tretinoin

2003
[LEUCOMELANODERMA CAUSED BY HYDROQUINONE].
    Revista da Associacao Medica Brasileira, 1965, Volume: 11

    Topics: Colonic Diseases; Humans; Hydroquinones; Melanosis; Phenols; Pigmentation Disorders; Toxicology

1965
Treatment of chloasma with monobenzyl ether of hydroquinone.
    A.M.A. archives of dermatology and syphilology, 1951, Volume: 64, Issue:5

    Topics: Ether; Ethers; Humans; Hydroquinones; Melanosis; Pigmentation; Quinones

1951
4% hydroquinone versus 4% hydroquinone, 0.05% dexamethasone and 0.05% tretinoin in the treatment of melasma: a comparative study.
    International journal of dermatology, 2005, Volume: 44, Issue:7

    Topics: Administration, Topical; Dermatologic Agents; Dexamethasone; Drug Combinations; Humans; Hydroquinone

2005
Cutaneous pseudolymphoma due to topical application of 4% hydroquinone cream for melasma.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2005, Volume: 15, Issue:8

    Topics: Adult; Face; Humans; Hydroquinones; Male; Melanosis; Pseudolymphoma; Skin Diseases

2005
Repeated treatment protocols for melasma and acquired dermal melanocytosis.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2006, Volume: 32, Issue:3

    Topics: Adult; Antioxidants; Asian People; Combined Modality Therapy; Drug Therapy, Combination; Facial Neop

2006
Validation of a melasma quality of life questionnaire for Brazilian Portuguese language: the MelasQoL-BP study and improvement of QoL of melasma patients after triple combination therapy.
    The British journal of dermatology, 2006, Volume: 156 Suppl 1

    Topics: Adult; Drug Therapy, Combination; Female; Fluocinolone Acetonide; Glucocorticoids; Humans; Hydroquin

2006
Therapeutical approaches in melasma.
    Dermatologic clinics, 2007, Volume: 25, Issue:3

    Topics: Chemexfoliation; Cosmetics; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Humans; Hydr

2007
Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy.
    International journal of dermatology, 2008, Volume: 47, Issue:1

    Topics: Administration, Cutaneous; Adult; Dermatologic Agents; Dermoscopy; Female; Humans; Hydroquinones; Hy

2008
An efficacy study of 3 commercially available hydroquinone 4% treatments for melasma.
    Cutis, 2007, Volume: 80, Issue:6

    Topics: Administration, Topical; Adult; Antioxidants; Female; Fluocinolone Acetonide; Humans; Hydroquinones;

2007
Use of hydroquinone as a bleaching cream.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:5

    Topics: Chemistry, Pharmaceutical; Humans; Hydroquinones; Melanosis; Ointments; Pigmentation Disorders

1993
[Minor symptoms in family medicine; chloasma or 'pregnancy mask'].
    Nederlands tijdschrift voor geneeskunde, 1995, Dec-23, Volume: 139, Issue:51

    Topics: Female; Humans; Hydroquinones; Melanosis; Ointments; Pigmentation Disorders; Pregnancy; Radiation-Pr

1995
The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1996, Volume: 22, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Drug Evaluation; Drug Therapy, Combination; Female; Glycolates; Huma

1996
Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs (Xoloitzcuintli).
    Laboratory animal science, 1998, Volume: 48, Issue:5

    Topics: Animals; Animals, Newborn; Cell Count; Dihydroxyphenylalanine; Dog Diseases; Dogs; Female; Hydroquin

1998
Melasma treated with hydroquinone, tretinoin, and a fluorinated steroid.
    International journal of dermatology, 2001, Volume: 40, Issue:3

    Topics: Adult; Anti-Inflammatory Agents; Antioxidants; Clinical Trials as Topic; Drug Combinations; Female;

2001
[Clinical evaluation of the efficacy of a topical preparation containing 2% hydroquinone in chloasma].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1987, Volume: 122, Issue:12

    Topics: Administration, Topical; Adult; Facial Dermatoses; Female; Humans; Hydroquinones; Melanosis; Middle

1987