hydrogen sulfide and Reperfusion Injury studies

Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

Excerpt	Relevance	Reference
"Rats with type 2 diabetes were exposed to GYY4137, a slow release donor of hydrogen sulfide with or without administration of the Sirtuin3 short hairpin ribonucleic acid plasmid, and then subjected to a surgical model of ischemia-reperfusion injury of the lung (n = 8)."	7.91	Hydrogen sulfide attenuates lung ischemia-reperfusion injury through SIRT3-dependent regulation of mitochondrial function in type 2 diabetic rats. ( Cui, X; Ding, W; Jiang, T; Liu, T; Liu, Y; Lv, X; Meng, Q; Yue, Z, 2019)
"Hydrogen sulfide (H2S) is an attractive agent for myocardial ischemia-reperfusion injury, however, systemic delivery of H2S may cause unwanted side effects."	7.83	Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury. ( Bin, J; Cao, S; Chen, G; Cui, K; Huang, Q; Kutty, S; Liao, W; Liao, Y; Wang, Y; Wu, J; Xiu, J; Yang, L; Zhang, W; Zhong, L, 2016)
"Cardiac mitochondrial dysfunction is considered to be the main manifestation in the pathology of ischemia reperfusion injury, and by restoring its functional activity, hydrogen sulfide (H2S), a novel endogenous gaseotransmitter renders cardioprotection."	7.83	Hydrogen sulfide post-conditioning preserves interfibrillar mitochondria of rat heart during ischemia reperfusion injury. ( Banu, SA; Kurian, GA; Ravindran, S, 2016)
"In this study, we investigated the impact of endogenous hydrogen sulfide (H2S) on toll-like receptors (TLRs)-mediated inflammatory response and apoptosis in renal ischemia-reperfusion injury (IRI)."	7.81	Impact of endogenous hydrogen sulfide on toll-like receptor pathway in renal ischemia/reperfusion injury in rats. ( Li, G; Li, R; Liu, W; Shi, Y; Tan, Z; Yan, Y, 2015)
"The present study was undertaken to study the effects of exogenous hydrogen sulfide (H(2)S) on global cerebral ischemia-reperfusion(I/R) and the underlying mechanisms."	7.79	Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats. ( Chen, G; Liu, Y; Ou, D; Tu, C; Xiao, X; Yin, J; Zhao, J, 2013)
"To explore the neuroprotective mechanism of exogenous hydrogen sulfide after cerebral ischemia-reperfusion (I/R) in rats."	7.79	[Neuroprotective mechanism of hydrogen sulfide after cerebral ischemia-reperfusion in rats]. ( Shen, Q; Yang, XS; Yin, J; Zeng, QH, 2013)
"To explore the relationship between the protection of hydrogen sulfide (H(2)S) against hepatic ischemia-reperfusion injury and thioredoxin system in rats."	7.78	[Alternation of thioredoxin system in postconditioning with hydrogen sulfide against hepatic ischemia-reperfusion injury in rats]. ( DU, J; Li, QM; Wang, GL; Wang, Q; Xie, KL; Zhang, BM, 2012)
"These findings confirm that the preischemic delivery of hydrogen sulfide limits ischemia-reperfusion injury-induced cellular damage in myotubes and skeletal muscle and suggests that, when given in the appropriate dose, this molecule may have significant therapeutic applications in multiple clinical scenarios."	7.76	Therapeutic metabolic inhibition: hydrogen sulfide significantly mitigates skeletal muscle ischemia reperfusion injury in vitro and in vivo. ( Henderson, PW; Kadouch, D; Krijgh, DD; Nagineni, V; Rafii, DC; Singh, SP; Spector, JA; Weinstein, AL, 2010)
"To investigate whether pharmacologic post-conditioning of intestinal tissue with hydrogen sulfide (HS) protects against ischemia reperfusion injury (IRI)."	7.76	Hydrogen sulfide attenuates intestinal ischemia-reperfusion injury when delivered in the post-ischemic period. ( Henderson, PW; Jimenez, N; Krijgh, DD; Sohn, AM; Spector, JA; Weinstein, AL, 2010)
"Hydrogen sulfide significantly attenuates ischemia-reperfusion injury in intestinal tissue in vitro and in vivo."	7.76	Hydrogen sulfide attenuates ischemia-reperfusion injury in in vitro and in vivo models of intestine free tissue transfer. ( Henderson, PW; Nagineni, V; Singh, SP; Spector, JA; Sung, J; Weinstein, AL, 2010)
"Hydrogen sulfide (H2S) has been known as a novel gaseous signaling molecule."	6.82	Administration of hydrogen sulfide protects ischemia reperfusion-induced acute kidney injury by reducing the oxidative stress. ( Ahghari, P; Azizi, F; Kadkhodaee, M; Seifi, B, 2016)
"Ischemic heart disease is one of the major causes of cardiovascular‑related mortality worldwide."	6.72	Cardioprotective effects of hydrogen sulfide in attenuating myocardial ischemia‑reperfusion injury (Review). ( Gu, Y; Wu, D; Zhu, D, 2021)
"Ischemia-reperfusion injury is caused by a period of ischemia followed by massive blood flow into a tissue that had experienced restricted blood flow."	6.61	Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis. ( Wenke, JC; Wetzel, MD, 2019)
"Hydrogen sulfide (H(2)S) has been known as a highly toxic gas for several centuries."	6.47	Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury. ( King, AL; Lefer, DJ, 2011)
"Ischemia-reperfusion injury is a critical liver condition during hepatic transplantation, trauma, or shock."	5.91	Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury. ( Bauer, M; Clemens, MG; Dahmen, U; Figge, MT; Kan, C; Lupp, A; Medyukhina, A; Nietzsche, S; Pennington, SA; Press, AT; Settmacher, U; Ungelenk, L; Wang, R; Wetzker, R, 2023)
"Testicular torsion is an acute pediatric surgical emergency requiring rapid diagnosis to prevent the permanent ischaemic damage of the testicles."	5.72	The effect of hydrogen sulfide on ischemi̇a /reperfusion injury in an experimental testicular torsion model. ( Aydın, F; Bingul, I; Erginel, B; Karatay, H; Keskin, E; Ozluk, Y; Yuksel, S, 2022)
"Hydrogen sulfide has been recognized as an important neuroprotective agent in the nervous system."	5.48	Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat. ( Jiang, A; Liu, Y; Pan, L; Yin, M, 2018)
"Hydrogen sulfide (H₂S) is an endogenous gaseous molecule with important physiological roles."	5.48	Beneficial Role of Hydrogen Sulfide in Renal Ischemia Reperfusion Injury in Rats. ( Choi, EK; Hong, SW; Jung, H; Kwak, KH; Lim, DG; Lim, JA; Park, SH; Park, SS, 2018)
"Autophagy is upregulated in spinal cord ischemia reperfusion (SCIR) injury; however, its expression mechanism is largely unknown; moreover, whether autophagy plays a neuroprotective or neurodegenerative role in SCIR injury remains controversial."	5.46	Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury. ( Li, C; Liang, Y; Xie, L; Yang, K; Yu, S, 2017)
"Cognitive dysfunction was detected in the hepatic I/R group, and this dysfunction was associated with a decrease in the mRNA and protein levels of the NR2B subunit of the NMDA receptors in the hippocampus."	5.43	Effects of hydrogen sulfide on cognitive dysfunction and NR2B in rats. ( Li, JX; Li, Q; Tu, FP; Wang, J, 2016)
"Hydrogen sulfide (H2S) functions as a protective gas transmitter in various physiological and pathological processes, but the lack of ideal donors severely hampers the clinical application of H2S."	5.43	Controlled release hydrogen sulfide delivery system based on mesoporous silica nanoparticles protects graft endothelium from ischemia-reperfusion injury. ( Guo, C; Liu, Y; Sun, X; Wang, C; Wang, W; Yang, C; Yang, W; Zhang, H, 2016)
"We investigated whether mild hypothermia combined with sodium hydrosulfide treatment during resuscitation improves neuron survival following cerebral ischemia-reperfusion injury beyond that observed for the individual treatments."	5.43	Mild Hypothermia Combined with Hydrogen Sulfide Treatment During Resuscitation Reduces Hippocampal Neuron Apoptosis Via NR2A, NR2B, and PI3K-Akt Signaling in a Rat Model of Cerebral Ischemia-Reperfusion Injury. ( Dai, HB; Duan, ML; Ji, XJ; Lv, J; Ma, RM; Miao, XL; Xu, MM; Zhu, SH, 2016)
"Hydrogen sulfide is a mediator of IRI and can ameliorate tissue injury in many organ systems."	5.42	Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats. ( Furness, P; Hosgood, SA; Hunter, JP; Nicholson, ML; Patel, M; Sayers, RD, 2015)
"Ischemia-reperfusion injury is unavoidable during organ transplantation."	5.42	Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation. ( Carter, D; Davison, M; Gunaratnam, L; Haig, A; Liu, W; Lobb, I; Sener, A, 2015)
"Focal ischemia was induced by 60-min middle cerebral artery occlusion (MCAO), followed by 23-h reperfusion."	5.40	Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia. ( Aboutaleb, N; Asadi, Y; Gheibi, A; Gheibi, S; Kalalian-Moghaddam, H; Khaksari, M; Mehrjerdi, FZ; Vakili, A, 2014)
"Hydrogen sulfide (H2S) has been proposed as a novel gas-transmittter, which plays multiple physiological and pathological functions in various body systems, including gastrointestinal tract."	5.40	Hydrogen sulfide protected gastric epithelial cell from ischemia/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-κB dependent anti-inflammation pathway. ( Guo, C; Liang, F; Shah Masood, W; Yan, X, 2014)
"Hydrogen sulfide treatment significantly increased L-selectin shedding from human neutrophils following activation by fMLP and interleukin-8 in an ADAM-17-dependent manner."	5.39	Hydrogen sulfide reduces neutrophil recruitment in hind-limb ischemia-reperfusion injury in an L-selectin and ADAM-17-dependent manner. ( Ball, CJ; Chintalapani, S; Kim, M; King, MR; Reiffel, AJ; Spector, JA, 2013)
"Hydrogen sulfide (H(2)S) was recently shown to be neuroprotective in the brain and retina due to its antiapoptotic effects."	5.37	Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia/reperfusion injury. ( Biermann, J; Goebel, U; Lagrèze, WA; Schallner, N; Schwer, CI, 2011)
"Hydrogen sulfide (H(2)S) is a gaseous messenger and serves as an important neuromodulator in central nervous system."	5.36	Dynamic change of hydrogen sulfide during global cerebral ischemia-reperfusion and its effect in rats. ( Du, A; Li, D; Mayhan, WG; Ren, C; Sui, J; Zhao, H, 2010)
"Hydrogen sulfide (H2S) is an endogenously gaseous mediator, regulating many pathophysiological functions in mammalian cells."	5.35	Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. ( Bai, XB; Cao, YX; Liu, H; Shi, S, 2009)
"Hydrogen sulfide (H(2)S) is an endogenously produced gaseous signaling molecule with diverse physiological activity."	5.35	Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling. ( Calvert, JW; Duranski, MR; Jha, S; Lefer, DJ; Ramachandran, A, 2008)
"53."	5.34	Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels. ( Huang, H; Liu, P; Tang, C; Wang, J; Zhang, Z, 2007)
"Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients."	4.40	Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Rats with type 2 diabetes were exposed to GYY4137, a slow release donor of hydrogen sulfide with or without administration of the Sirtuin3 short hairpin ribonucleic acid plasmid, and then subjected to a surgical model of ischemia-reperfusion injury of the lung (n = 8)."	3.91	Hydrogen sulfide attenuates lung ischemia-reperfusion injury through SIRT3-dependent regulation of mitochondrial function in type 2 diabetic rats. ( Cui, X; Ding, W; Jiang, T; Liu, T; Liu, Y; Lv, X; Meng, Q; Yue, Z, 2019)
"This study aims to explore the effects of the exogenous hydrogen sulfide (H2S)-mediated scavenger receptor A (SR-A) signaling pathway on renal ischemia/reperfusion injury (IRI) by regulating endoplasmic reticulum (ER) stress-induced autophagy in rats."	3.85	Roles of the Exogenous H2S-Mediated SR-A Signaling Pathway in Renal Ischemia/ Reperfusion Injury in Regulating Endoplasmic Reticulum Stress-Induced Autophagy in a Rat Model. ( Ling, Q; Liu, JH; Wang, SG; Wang, T; Ye, ZQ; Yu, X, 2017)
"Emerging evidence has suggested that hydrogen sulfide (H2S) may alleviate the cellular damage associated with cerebral ischemia/reperfusion (I/R) injury."	3.85	The administration of hydrogen sulphide prior to ischemic reperfusion has neuroprotective effects in an acute stroke model. ( Choi, CG; Choi, Y; Ha, HK; Ham, SJ; Jeon, SB; Jung, SC; Kim, J; Kim, JK; Kim, KW; Kim, ST; Kwon, JI; Shim, WH; Sung, YS; Woo, CW; Woo, DC, 2017)
"Hydrogen sulfide (H2S) can protect against hepatic ischemia-reperfusion injury (HIR)."	3.83	Silymarin preconditioning protected insulin resistant rats from liver ischemia-reperfusion injury: role of endogenous H2S. ( Mahmoud, MF; Shaheen, MA; Younis, NN, 2016)
"Cardiac mitochondrial dysfunction is considered to be the main manifestation in the pathology of ischemia reperfusion injury, and by restoring its functional activity, hydrogen sulfide (H2S), a novel endogenous gaseotransmitter renders cardioprotection."	3.83	Hydrogen sulfide post-conditioning preserves interfibrillar mitochondria of rat heart during ischemia reperfusion injury. ( Banu, SA; Kurian, GA; Ravindran, S, 2016)
"Hydrogen sulfide (H2S) is an attractive agent for myocardial ischemia-reperfusion injury, however, systemic delivery of H2S may cause unwanted side effects."	3.83	Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury. ( Bin, J; Cao, S; Chen, G; Cui, K; Huang, Q; Kutty, S; Liao, W; Liao, Y; Wang, Y; Wu, J; Xiu, J; Yang, L; Zhang, W; Zhong, L, 2016)
"In this study, we investigated the impact of endogenous hydrogen sulfide (H2S) on toll-like receptors (TLRs)-mediated inflammatory response and apoptosis in renal ischemia-reperfusion injury (IRI)."	3.81	Impact of endogenous hydrogen sulfide on toll-like receptor pathway in renal ischemia/reperfusion injury in rats. ( Li, G; Li, R; Liu, W; Shi, Y; Tan, Z; Yan, Y, 2015)
" In a mouse model of DR-mediated stress resistance, we found that sulfur amino acid (SAA) restriction increased expression of the transsulfuration pathway (TSP) enzyme cystathionine γ-lyase (CGL), resulting in increased hydrogen sulfide (H2S) production and protection from hepatic ischemia reperfusion injury."	3.81	Endogenous hydrogen sulfide production is essential for dietary restriction benefits. ( Brace, L; Gladyshev, VN; Harputlugil, E; Hine, C; Lee, BC; Longchamp, A; Madeo, F; Mair, WB; Mejia, P; Mitchell, JR; Ozaki, CK; Ruckenstuhl, C; Treviño-Villarreal, JH; Wang, R; Zhang, Y, 2015)
"To explore the neuroprotective mechanism of exogenous hydrogen sulfide after cerebral ischemia-reperfusion (I/R) in rats."	3.79	[Neuroprotective mechanism of hydrogen sulfide after cerebral ischemia-reperfusion in rats]. ( Shen, Q; Yang, XS; Yin, J; Zeng, QH, 2013)
"The present study was undertaken to study the effects of exogenous hydrogen sulfide (H(2)S) on global cerebral ischemia-reperfusion(I/R) and the underlying mechanisms."	3.79	Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats. ( Chen, G; Liu, Y; Ou, D; Tu, C; Xiao, X; Yin, J; Zhao, J, 2013)
"To explore the relationship between the protection of hydrogen sulfide (H(2)S) against hepatic ischemia-reperfusion injury and thioredoxin system in rats."	3.78	[Alternation of thioredoxin system in postconditioning with hydrogen sulfide against hepatic ischemia-reperfusion injury in rats]. ( DU, J; Li, QM; Wang, GL; Wang, Q; Xie, KL; Zhang, BM, 2012)
"Hydrogen sulfide significantly attenuates ischemia-reperfusion injury in intestinal tissue in vitro and in vivo."	3.76	Hydrogen sulfide attenuates ischemia-reperfusion injury in in vitro and in vivo models of intestine free tissue transfer. ( Henderson, PW; Nagineni, V; Singh, SP; Spector, JA; Sung, J; Weinstein, AL, 2010)
"To investigate whether pharmacologic post-conditioning of intestinal tissue with hydrogen sulfide (HS) protects against ischemia reperfusion injury (IRI)."	3.76	Hydrogen sulfide attenuates intestinal ischemia-reperfusion injury when delivered in the post-ischemic period. ( Henderson, PW; Jimenez, N; Krijgh, DD; Sohn, AM; Spector, JA; Weinstein, AL, 2010)
"To study the protective function and pathophysiology of cystathionine gamma-lyase (CSE)/hydrogen sulfide (H(2)S) system in hepatic ischemia-reperfusion injury (HIRI) in rats."	3.76	[Protection of CSE/H2S system in hepatic ischemia reperfusion injury in rats]. ( Jiang, HC; Kang, K; Pan, SH; Sun, XY; Zhao, MY, 2010)
"These findings confirm that the preischemic delivery of hydrogen sulfide limits ischemia-reperfusion injury-induced cellular damage in myotubes and skeletal muscle and suggests that, when given in the appropriate dose, this molecule may have significant therapeutic applications in multiple clinical scenarios."	3.76	Therapeutic metabolic inhibition: hydrogen sulfide significantly mitigates skeletal muscle ischemia reperfusion injury in vitro and in vivo. ( Henderson, PW; Kadouch, D; Krijgh, DD; Nagineni, V; Rafii, DC; Singh, SP; Spector, JA; Weinstein, AL, 2010)
"Hydrogen sulfide (H2S) displays anti-inflammatory and cytoprotective activities as evidenced by the inhibition of myocardial ischemia-reperfusion injury and production of lipid peroxidation."	3.75	Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats. ( Jiang, H; Kang, K; Pan, S; Sun, X; Tan, G; Zhao, M, 2009)
"Hydrogen sulfide (H2S) has been known as a novel gaseous signaling molecule."	2.82	Administration of hydrogen sulfide protects ischemia reperfusion-induced acute kidney injury by reducing the oxidative stress. ( Ahghari, P; Azizi, F; Kadkhodaee, M; Seifi, B, 2016)
"Ischemic heart disease is one of the major causes of cardiovascular‑related mortality worldwide."	2.72	Cardioprotective effects of hydrogen sulfide in attenuating myocardial ischemia‑reperfusion injury (Review). ( Gu, Y; Wu, D; Zhu, D, 2021)
"Ischemia-reperfusion injury is caused by a period of ischemia followed by massive blood flow into a tissue that had experienced restricted blood flow."	2.61	Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis. ( Wenke, JC; Wetzel, MD, 2019)
"While we focus on hemorrhagic shock, many of the described treatments may be used in other situations of hypoxia or ischemia/reperfusion injury."	2.58	Hibernation-Based Approaches in the Treatment of Hemorrhagic Shock. ( Beilman, GJ; Lusczek, ER; Wolf, A, 2018)
"Hydrogen sulfide (H(2)S) is a gasomediator synthesized from L- and D-cysteine in various tissues."	2.53	Medical Functions of Hydrogen Sulfide. ( Olas, B, 2016)
"Hydrogen sulfide (H(2)S) has been known as a highly toxic gas for several centuries."	2.47	Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury. ( King, AL; Lefer, DJ, 2011)
"Hydrogen sulfide (H(2)S) is a colorless, water soluble, flammable gas that has the characteristic smell of rotten eggs."	2.46	Novel insights into hydrogen sulfide--mediated cytoprotection. ( Calvert, JW; Coetzee, WA; Lefer, DJ, 2010)
"1."	2.46	Interaction of hydrogen sulfide with ion channels. ( Tang, G; Wang, R; Wu, L, 2010)
" Finally, in addition to the question of dosing and timing (for example, bolus administration versus continuous intravenous infusion), the preferred route of H2S administration remains to be settled--that is, inhaling gaseous H2S versus intra-venous administration of injectable H2S preparations or H2S donors."	2.45	Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical care. ( Asfar, P; Calzia, E; Radermacher, P; Szabó, C; Wagner, F, 2009)
"Ischemia-reperfusion injury is a critical liver condition during hepatic transplantation, trauma, or shock."	1.91	Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury. ( Bauer, M; Clemens, MG; Dahmen, U; Figge, MT; Kan, C; Lupp, A; Medyukhina, A; Nietzsche, S; Pennington, SA; Press, AT; Settmacher, U; Ungelenk, L; Wang, R; Wetzker, R, 2023)
"Testicular torsion is an acute pediatric surgical emergency requiring rapid diagnosis to prevent the permanent ischaemic damage of the testicles."	1.72	The effect of hydrogen sulfide on ischemi̇a /reperfusion injury in an experimental testicular torsion model. ( Aydın, F; Bingul, I; Erginel, B; Karatay, H; Keskin, E; Ozluk, Y; Yuksel, S, 2022)
"Our main objective was to investigate the effect of chronic administration of hydrogen sulphide donor (sodium hydrosulphide) on the expression of intercellular adhesion molecule-1 (ICAM-1) and concentration of nuclear factor-kappa B (NF-kB) in a renal ischemia-reperfusion injury (IRI) model of WKY and L-nitro-arginine-methyl-ester (L-NAME)-induced hypertensive rats."	1.62	Hydrogen Sulphide Treatment Prevents Renal Ischemia-Reperfusion Injury by Inhibiting the Expression of ICAM-1 and NF-kB Concentration in Normotensive and Hypertensive Rats. ( Ahmad, A; Chia, TY; Gan, CY; Hashmi, SF; Johns, EJ; Rathore, HA; Sattar, MA, 2021)
"Trimetazidine is a piperazine-derived metabolic agent."	1.51	The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress. ( Liu, C; Zheng, W, 2019)
"Hydrogen sulfide (H₂S) is an endogenous gaseous molecule with important physiological roles."	1.48	Beneficial Role of Hydrogen Sulfide in Renal Ischemia Reperfusion Injury in Rats. ( Choi, EK; Hong, SW; Jung, H; Kwak, KH; Lim, DG; Lim, JA; Park, SH; Park, SS, 2018)
"Hydrogen sulfide has been recognized as an important neuroprotective agent in the nervous system."	1.48	Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat. ( Jiang, A; Liu, Y; Pan, L; Yin, M, 2018)
"Hydrogen sulfide (H₂S) is an endogenous mediator, synthesized from l-cysteine by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) or 3-mercaptopyruvate sulfurtransferase (3-MST)."	1.46	Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations. ( Brzozowski, T; Ginter, G; Hubalewska-Mazgaj, M; Kwiecien, S; Magierowska, K; Magierowski, M; Pajdo, R; Sliwowski, Z, 2017)
"Autophagy is upregulated in spinal cord ischemia reperfusion (SCIR) injury; however, its expression mechanism is largely unknown; moreover, whether autophagy plays a neuroprotective or neurodegenerative role in SCIR injury remains controversial."	1.46	Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury. ( Li, C; Liang, Y; Xie, L; Yang, K; Yu, S, 2017)
"Hydrogen sulfide (H2S) functions as a protective gas transmitter in various physiological and pathological processes, but the lack of ideal donors severely hampers the clinical application of H2S."	1.43	Controlled release hydrogen sulfide delivery system based on mesoporous silica nanoparticles protects graft endothelium from ischemia-reperfusion injury. ( Guo, C; Liu, Y; Sun, X; Wang, C; Wang, W; Yang, C; Yang, W; Zhang, H, 2016)
"Cognitive dysfunction was detected in the hepatic I/R group, and this dysfunction was associated with a decrease in the mRNA and protein levels of the NR2B subunit of the NMDA receptors in the hippocampus."	1.43	Effects of hydrogen sulfide on cognitive dysfunction and NR2B in rats. ( Li, JX; Li, Q; Tu, FP; Wang, J, 2016)
"We investigated whether mild hypothermia combined with sodium hydrosulfide treatment during resuscitation improves neuron survival following cerebral ischemia-reperfusion injury beyond that observed for the individual treatments."	1.43	Mild Hypothermia Combined with Hydrogen Sulfide Treatment During Resuscitation Reduces Hippocampal Neuron Apoptosis Via NR2A, NR2B, and PI3K-Akt Signaling in a Rat Model of Cerebral Ischemia-Reperfusion Injury. ( Dai, HB; Duan, ML; Ji, XJ; Lv, J; Ma, RM; Miao, XL; Xu, MM; Zhu, SH, 2016)
"Hydrogen sulfide is a mediator of IRI and can ameliorate tissue injury in many organ systems."	1.42	Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats. ( Furness, P; Hosgood, SA; Hunter, JP; Nicholson, ML; Patel, M; Sayers, RD, 2015)
"Ischemia-reperfusion injury is unavoidable during organ transplantation."	1.42	Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation. ( Carter, D; Davison, M; Gunaratnam, L; Haig, A; Liu, W; Lobb, I; Sener, A, 2015)
"Transient cerebral ischemia was induced using the Pulsinelli four-vessel occlusion method."	1.42	Hydrogen sulphide and mild hypothermia activate the CREB signaling pathway and prevent ischemia-reperfusion injury. ( Dai, HB; Duan, ML; Hu, YM; Ji, X; Li, WY; Ma, RM; Miao, XL; Zhang, LD; Zhu, SH, 2015)
"Focal ischemia was induced by 60-min middle cerebral artery occlusion (MCAO), followed by 23-h reperfusion."	1.40	Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia. ( Aboutaleb, N; Asadi, Y; Gheibi, A; Gheibi, S; Kalalian-Moghaddam, H; Khaksari, M; Mehrjerdi, FZ; Vakili, A, 2014)
"Hydrogen sulfide (H2S) has been proposed as a novel gas-transmittter, which plays multiple physiological and pathological functions in various body systems, including gastrointestinal tract."	1.40	Hydrogen sulfide protected gastric epithelial cell from ischemia/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-κB dependent anti-inflammation pathway. ( Guo, C; Liang, F; Shah Masood, W; Yan, X, 2014)
"The rat model of global cerebral ischemia/reperfusion injury was established by bilateral common carotid arteries occlusion combined with hemorrhagic hypotension."	1.39	[Protective effect of H2S pretreatment on cerebral ischemia-reperfusion injury and its mechanisms in rats]. ( Gao, L; Gu, LZ; Guo, J; Qin, H, 2013)
"Hydrogen sulfide (H2S) is an endogenous gasotransmitter with physiologic functions similar to nitric oxide and carbon monoxide."	1.39	Cystathionine γ-lyase protects against renal ischemia/reperfusion by modulating oxidative stress. ( Boersema, M; Bos, EM; Damman, J; Fu, M; Hillebrands, JL; Leuvenink, HG; Moser, J; Ploeg, RJ; Snijder, PM; van Goor, H; Wang, R; Yang, G, 2013)
"Hydrogen sulfide treatment significantly increased L-selectin shedding from human neutrophils following activation by fMLP and interleukin-8 in an ADAM-17-dependent manner."	1.39	Hydrogen sulfide reduces neutrophil recruitment in hind-limb ischemia-reperfusion injury in an L-selectin and ADAM-17-dependent manner. ( Ball, CJ; Chintalapani, S; Kim, M; King, MR; Reiffel, AJ; Spector, JA, 2013)
"Ischemia-reperfusion injury is a common complication after lung transplantation."	1.38	Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation. ( Arnaoutakis, GJ; Beaty, CA; Berkowitz, DE; George, TJ; Jandu, SK; Santhanam, L; Shah, AS, 2012)
"Hydrogen sulfide (H(2)S) is a novel agent previously shown to slow metabolism and scavenge reactive oxygen species, potentially mitigating IRI."	1.38	Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation. ( Arnaoutakis, GJ; Beaty, CA; Berkowitz, DE; George, TJ; Jandu, SK; Santhanam, L; Shah, AS, 2012)
"S-memantine was synthesized by chemically combining a slow releasing H(2)S donor 4-(3-thioxo-3H-1,2-dithiol-4-yl)-benzoic acid (ACS48) with a NMDAR antagonist memantine."	1.38	A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. ( Arai, K; Atochin, DN; Ichinose, F; Khatri, A; Kida, K; Kosugi, S; Marutani, E; Nguyen, R; Tokuda, K; Van Leyen, K, 2012)
"Hydrogen sulfide (H₂S) is a physiologic gaseous signaling molecule, like nitric oxide (NO) and carbon monoxide (CO)."	1.37	Delivery of the bioactive gas hydrogen sulfide during cold preservation of rat liver: effects on hepatic function in an ex vivo model. ( Balaban, CL; Guibert, EE; Rodriguez, JV, 2011)
"Hydrogen sulfide (H(2)S) was recently shown to be neuroprotective in the brain and retina due to its antiapoptotic effects."	1.37	Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia/reperfusion injury. ( Biermann, J; Goebel, U; Lagrèze, WA; Schallner, N; Schwer, CI, 2011)
"Hydrogen sulfide (H(2)S) is a gaseous messenger and serves as an important neuromodulator in central nervous system."	1.36	Dynamic change of hydrogen sulfide during global cerebral ischemia-reperfusion and its effect in rats. ( Du, A; Li, D; Mayhan, WG; Ren, C; Sui, J; Zhao, H, 2010)
"Hydrogen sulfide (H(2)S) is an endogenously produced gaseous signaling molecule with diverse physiological activity."	1.35	Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling. ( Calvert, JW; Duranski, MR; Jha, S; Lefer, DJ; Ramachandran, A, 2008)
"Hydrogen sulfide (H2S) is an endogenously gaseous mediator, regulating many pathophysiological functions in mammalian cells."	1.35	Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. ( Bai, XB; Cao, YX; Liu, H; Shi, S, 2009)
"53."	1.34	Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels. ( Huang, H; Liu, P; Tang, C; Wang, J; Zhang, Z, 2007)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	15 (10.56)	29.6817
2010's	106 (74.65)	24.3611
2020's	21 (14.79)	2.80

Trial	Enrollment	Study Type	Start Date	Status
Dietary Restriction in Vascular Surgery[NCT04013412]	19 participants (Actual)	Interventional	2018-12-31	Completed
Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease[NCT05457881]	226 participants (Anticipated)	Interventional	2024-03-01	Not yet recruiting
Short-Term Endogenous Hydrogen Sulfide Upregulation[NCT03303534]	9 participants (Actual)	Interventional	2017-09-14	Completed
Hydrogen Sulfide and Peripheral Arterial Disease[NCT01407172]	252 participants (Actual)	Observational	2011-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Cardioprotective effects of hydrogen sulfide in attenuating myocardial ischemia‑reperfusion injury (Review). Molecular medicine reports, 2021, Volume: 24, Issue:6 Topics: Animals; Cardiotonic Agents; Heart; Humans; Hydrogen Sulfide; Ischemic Postconditioning; Myocardial	2021
Protective Effect of Hydrogen Sulfide on Cerebral Ischemia-Reperfusion Injury. Cellular and molecular neurobiology, 2023, Volume: 43, Issue:1 Topics: Apoptosis; Humans; Hydrogen Sulfide; Hypoxia; Oxidative Stress; Reperfusion Injury	2023
Cystathionine beta-Synthase in hypoxia and ischemia/reperfusion: A current overview. Archives of biochemistry and biophysics, 2022, 03-30, Volume: 718 Topics: Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Humans; Hydrogen Sulfide; Hypoxia; Ischemia;	2022
Effect of hydrogen sulfide on ischemia-reperfusion injury of kidney: A systematic review and meta-analysis of in vivo animal studies. European journal of pharmacology, 2023, Mar-15, Volume: 943 Topics: Animals; Creatinine; Hydrogen Sulfide; Kidney; Reperfusion Injury	2023
Pre-Treatment of Transplant Donors with Hydrogen Sulfide to Protect against Warm and Cold Ischemia-Reperfusion Injury in Kidney and Other Transplantable Solid Organs. International journal of molecular sciences, 2023, Feb-09, Volume: 24, Issue:4 Topics: Animals; Humans; Hydrogen Sulfide; Kidney; Kidney Transplantation; Reperfusion Injury; Tissue Donors	2023
Hydrogen sulfide and its donors for the treatment of cerebral ischaemia-reperfusion injury: A comprehensive review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 161 Topics: Animals; Brain Injuries; Brain Ischemia; Cerebral Infarction; Hydrogen Sulfide; Mammals; Oxidative S	2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. Science & sports, 2023, Apr-04 Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp	2023
Molecular strategies used by hibernators: Potential therapeutic directions for ischemia reperfusion injury and preservation of human donor organs. Transplantation reviews (Orlando, Fla.), 2020, Volume: 34, Issue:1 Topics: Adenylate Kinase; Animals; Cryobiology; Heme Oxygenase-1; Hibernation; Humans; Hydrogen Sulfide; Mod	2020
The Role of Reactive Oxygen Species, Kinases, Hydrogen Sulfide, and Nitric Oxide in the Regulation of Autophagy and Their Impact on Ischemia and Reperfusion Injury in the Heart. Current cardiology reviews, 2021, Volume: 17, Issue:4 Topics: Autophagy; Humans; Hydrogen Sulfide; Ischemia; Myocytes, Cardiac; Nitric Oxide; Reactive Oxygen Spec	2021
Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms. International journal of molecular sciences, 2021, Jun-16, Volume: 22, Issue:12 Topics: Animals; Gastrointestinal Hormones; Humans; Hydrogen Sulfide; Metabolic Networks and Pathways; Oxida	2021
H Pharmacological research, 2021, Volume: 172 Topics: Animals; Cold Ischemia; Humans; Hydrogen Sulfide; Models, Animal; Organ Transplantation; Reperfusion	2021
Hibernation-Based Approaches in the Treatment of Hemorrhagic Shock. Shock (Augusta, Ga.), 2018, Volume: 50, Issue:1 Topics: Animals; Hibernation; Humans; Hydrogen Sulfide; Melatonin; Reperfusion Injury; Shock, Hemorrhagic	2018
A CRITICAL REVIEW ON PHARMACOLOGICAL SIGNIFICANCE OF HYDROGEN SULFIDE (H₂S) ON NF-κB CONCENTRATION AND ICAM-1 EXPRESSION IN RENAL ISCHEMIA REPERFUSION INJURY. Acta poloniae pharmaceutica, 2017, Volume: 74, Issue:3 Topics: Acute Kidney Injury; Animals; Humans; Hydrogen Sulfide; Intercellular Adhesion Molecule-1; Kidney; K	2017
Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis. Journal of translational medicine, 2019, 01-21, Volume: 17, Issue:1 Topics: Animals; Apoptosis; Humans; Hydrogen Sulfide; Mitochondria; Muscles; Proto-Oncogene Proteins c-akt;	2019
Hydrogen sulfide in pharmacology and medicine--An update. Pharmacological reports : PR, 2015, Volume: 67, Issue:3 Topics: Animals; Humans; Hydrogen Sulfide; Mitochondria; Neoplasms; Reperfusion Injury; Signal Transduction	2015
Molecular Dissection of Renal Ischemia-Reperfusion: Oxidative Stress and Cellular Events. Current medicinal chemistry, 2016, Volume: 23, Issue:19 Topics: Acute Kidney Injury; Gene Expression; Heat-Shock Proteins; Humans; Hydrogen Sulfide; Inflammation; M	2016
Medical Functions of Hydrogen Sulfide. Advances in clinical chemistry, 2016, Volume: 74 Topics: Angiogenesis Inducing Agents; Cardiovascular Agents; Cysteine; Diclofenac; Disulfides; Heart; Humans	2016
Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical care. Critical care (London, England), 2009, Volume: 13, Issue:3 Topics: Animals; Hibernation; Humans; Hydrogen Sulfide; Inflammation; Reperfusion Injury; Shock; Signal Tran	2009
Novel insights into hydrogen sulfide--mediated cytoprotection. Antioxidants & redox signaling, 2010, May-15, Volume: 12, Issue:10 Topics: Air Pollutants; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Vessels; Cardiotonic Agents;	2010
Hydrogen sulfide and ischemia-reperfusion injury. Pharmacological research, 2010, Volume: 62, Issue:4 Topics: Animals; Cytoprotection; Humans; Hydrogen Sulfide; Reperfusion Injury	2010
Interaction of hydrogen sulfide with ion channels. Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:7 Topics: Animals; ATP-Binding Cassette Transporters; Cytoprotection; Humans; Hydrogen Sulfide; Ion Channels;	2010
Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury. Experimental physiology, 2011, Volume: 96, Issue:9 Topics: Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cytoprotection; Humans; Hydrogen Sulfide; Li	2011
Modulation of h(2)s metabolism by statins: a new aspect of cardiovascular pharmacology. Antioxidants & redox signaling, 2012, Jul-01, Volume: 17, Issue:1 Topics: Animals; Humans; Hydrogen Sulfide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Reperfusion Injur	2012
Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury. Current opinion in nephrology and hypertension, 2012, Volume: 21, Issue:1 Topics: Acute Kidney Injury; Angiopoietin-1; Animals; Atrial Natriuretic Factor; Carbon Monoxide; Heme Oxyge	2012
Ischemia-reperfusion injury: influencing the microcirculatory and cellular environment. Annals of plastic surgery, 2014, Volume: 72, Issue:2 Topics: Cardiovascular Agents; Cell Adhesion Molecules; Endothelium-Dependent Relaxing Factors; Free Radical	2014

Article	Year
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. Science & sports, 2023, Apr-04 Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp	2023
Administration of hydrogen sulfide protects ischemia reperfusion-induced acute kidney injury by reducing the oxidative stress. Irish journal of medical science, 2016, Volume: 185, Issue:3 Topics: Acute Kidney Injury; Animals; Hydrogen Sulfide; Kidney; Male; Oxidative Stress; Rats; Rats, Wistar;	2016

Article	Year
Hydrogen Sulfide Reduces Ischemia and Reperfusion Injury in Neuronal Cells in a Dose- and Time-Dependent Manner. International journal of molecular sciences, 2021, Sep-18, Volume: 22, Issue:18 Topics: Animals; Apoptosis; Cytokines; Dose-Response Relationship, Drug; Drug Administration Schedule; Hydro	2021
Hydrogen Sulphide Treatment Prevents Renal Ischemia-Reperfusion Injury by Inhibiting the Expression of ICAM-1 and NF-kB Concentration in Normotensive and Hypertensive Rats. Biomolecules, 2021, 10-19, Volume: 11, Issue:10 Topics: Acute Kidney Injury; Animals; Gene Expression Regulation; Humans; Hydrogen Sulfide; Intercellular Ad	2021
Quercetin ameliorated remote myocardial injury induced by renal ischemia/reperfusion in rats: Role of Rho-kinase and hydrogen sulfide. Life sciences, 2021, Dec-15, Volume: 287 Topics: Animals; Antioxidants; Hydrogen Sulfide; Kidney; Male; Myocardial Infarction; Quercetin; Rats; Rats,	2021
The effect of hydrogen sulfide on ischemi̇a /reperfusion injury in an experimental testicular torsion model. Journal of pediatric urology, 2022, Volume: 18, Issue:1 Topics: Animals; Humans; Hydrogen Sulfide; Male; Malondialdehyde; Rats; Rats, Wistar; Reperfusion Injury; Sp	2022
SAM, a cystathionine beta-synthase activator, promotes hydrogen sulfide to promote neural repair resulting from massive cerebral infarction induced by middle cerebral artery occlusion. Metabolic brain disease, 2022, Volume: 37, Issue:5 Topics: Animals; Apoptosis; Brain Ischemia; Cystathionine beta-Synthase; Glucose; Glutamic Acid; Humans; Hyd	2022
Comparison of Inflation and Ventilation with Hydrogen Sulfide during the Warm Ischemia Phase on Ischemia-Reperfusion Injury in a Rat Model of Non-Heart-Beating Donor Lung Transplantation. BioMed research international, 2023, Volume: 2023 Topics: Animals; Hydrogen Sulfide; Lung; Lung Transplantation; Pulmonary Surfactants; Rats; Reperfusion Inju	2023
Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury. Free radical biology & medicine, 2023, 08-01, Volume: 204 Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury, Chronic; Glutathione; Hydrogen Sulfid	2023
The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress. Anatolian journal of cardiology, 2019, Volume: 22, Issue:3 Topics: Animals; Apoptosis; Cardiotonic Agents; Cystathionine gamma-Lyase; Disease Models, Animal; Hydrogen	2019
Protective effect of GYY4137, a water‑soluble hydrogen sulfide‑releasing molecule, on intestinal ischemia‑reperfusion. Molecular medicine reports, 2020, Volume: 21, Issue:3 Topics: Animals; Apoptosis; Biomarkers; Disease Models, Animal; Gene Expression; Hydrogen Sulfide; Immunohis	2020
Kidney Ischemia-Reperfusion Decreases Hydrogen Sulfide and Increases Oxidative Stress in the Heart. Biomolecules, 2020, 11-17, Volume: 10, Issue:11 Topics: Acute Kidney Injury; Animals; Female; Hydrogen Sulfide; Male; Myocardium; Oxidative Stress; Rats; Ra	2020
Activation of the CaR-CSE/H2S pathway confers cardioprotection against ischemia-reperfusion injury. Experimental cell research, 2021, 01-15, Volume: 398, Issue:2 Topics: Animals; Apoptosis; Cells, Cultured; Cystathionine gamma-Lyase; Disease Models, Animal; Endothelial	2021
Roles of the Exogenous H2S-Mediated SR-A Signaling Pathway in Renal Ischemia/ Reperfusion Injury in Regulating Endoplasmic Reticulum Stress-Induced Autophagy in a Rat Model. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 41, Issue:6 Topics: Animals; Autophagy; Creatine; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasm	2017
Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury. Oxidative medicine and cellular longevity, 2017, Volume: 2017 Topics: Animals; Autophagy; Disease Models, Animal; Humans; Hydrogen Sulfide; Male; Oxidative Stress; Rats;	2017
A Hibernation-Like State for Transplantable Organs: Is Hydrogen Sulfide Therapy the Future of Organ Preservation? Antioxidants & redox signaling, 2018, 06-01, Volume: 28, Issue:16 Topics: Animals; Hibernation; Humans; Hydrogen Sulfide; Kidney Transplantation; Organ Preservation; Reperfus	2018
Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine. The Journal of surgical research, 2017, Volume: 219 Topics: Acute Kidney Injury; Animals; Female; Gasotransmitters; Hydrogen Sulfide; Infusions, Intra-Arterial;	2017
The administration of hydrogen sulphide prior to ischemic reperfusion has neuroprotective effects in an acute stroke model. PloS one, 2017, Volume: 12, Issue:11 Topics: Animals; Apoptosis; Aspartic Acid; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Humans; Hy	2017
Exogenous Hydrogen Sulfide Protects SH-SY5Y Cells from OGD/RInduced Injury. Current molecular medicine, 2017, Volume: 17, Issue:8 Topics: Cell Survival; Gasotransmitters; Glucose; Humans; Hydrogen Sulfide; Neuroblastoma; Neuroprotective A	2017
Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 98 Topics: Animals; Apoptosis; Base Sequence; Beclin-1; Cell Line; Disease Models, Animal; Glucose; Humans; Hyd	2018
Beneficial Role of Hydrogen Sulfide in Renal Ischemia Reperfusion Injury in Rats. Yonsei medical journal, 2018, Volume: 59, Issue:8 Topics: Animals; Apoptosis; Creatinine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Extracellula	2018
[INFLUENCE OF HYDROGEN SULFIDE ON BLOOD OXYGEN PARAMETERS DURING HEPATIC ISCHEMIA-REPERFUSION IN RATS]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2016, Volume: 102, Issue:6 Topics: Animals; Hydrogen Sulfide; Liver; Liver Diseases; Male; Oxygen; Rats; Reperfusion Injury	2016
Characterization and Biological Activity of a Hydrogen Sulfide-Releasing Red Light-Activated Ruthenium(II) Complex. Journal of the American Chemical Society, 2018, 10-03, Volume: 140, Issue:39 Topics: A549 Cells; Cell Line; Coordination Complexes; Crystallography, X-Ray; Humans; Hydrogen Sulfide; Mor	2018
H Nitric oxide : biology and chemistry, 2018, 12-01, Volume: 81 Topics: Adenosine; Allopurinol; Animals; Apoptosis; Cell Line; Cell Survival; Cytoprotection; Epithelial Cel	2018
Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia. The Journal of surgical research, 2019, Volume: 234 Topics: Animals; Biomarkers; Cytokines; Drug Administration Schedule; Endothelium, Vascular; Enterocolitis,	2019
Breathing hydrogen sulfide prevents delayed paraplegia in mice. Free radical biology & medicine, 2019, 02-01, Volume: 131 Topics: Administration, Inhalation; Animals; Apoptosis; bcl-X Protein; Cell Line, Tumor; Gene Expression Reg	2019
Hydrogen sulfide attenuates lung ischemia-reperfusion injury through SIRT3-dependent regulation of mitochondrial function in type 2 diabetic rats. Surgery, 2019, Volume: 165, Issue:5 Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Drug	2019
Supplementing preservation solution with mitochondria-targeted H American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019, Volume: 19, Issue:11 Topics: Animals; Heart Transplantation; Hydrogen Sulfide; Male; Mice; Mice, Inbred C57BL; Mitochondria; Orga	2019
Hydrogen sulfide reduces neutrophil recruitment in hind-limb ischemia-reperfusion injury in an L-selectin and ADAM-17-dependent manner. Plastic and reconstructive surgery, 2013, Volume: 131, Issue:3 Topics: ADAM Proteins; ADAM17 Protein; Animals; Hindlimb; Hydrogen Sulfide; L-Selectin; Male; Mice; Mice, In	2013
Cystathionine γ-lyase protects against renal ischemia/reperfusion by modulating oxidative stress. Journal of the American Society of Nephrology : JASN, 2013, Volume: 24, Issue:5 Topics: Adolescent; Adult; Aged; Animals; Cell Survival; Cystathionine beta-Synthase; Cystathionine gamma-Ly	2013
Acetylcholine- and sodium hydrosulfide-induced endothelium-dependent relaxation and hyperpolarization in cerebral vessels of global cerebral ischemia-reperfusion rat. Journal of pharmacological sciences, 2013, Volume: 121, Issue:4 Topics: Acetylcholine; Animals; Biological Factors; Cerebral Arteries; Disease Models, Animal; Endothelium,	2013
Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice. American journal of physiology. Heart and circulatory physiology, 2013, Aug-15, Volume: 305, Issue:4 Topics: Animals; Benzoates; Biphenyl Compounds; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal	2013
[Protective effect of H2S pretreatment on cerebral ischemia-reperfusion injury and its mechanisms in rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2013, Volume: 35, Issue:3 Topics: Animals; Brain Ischemia; Free Radicals; Hippocampus; HSP70 Heat-Shock Proteins; Hydrogen Sulfide; Ma	2013
Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury. Critical care (London, England), 2013, Jul-10, Volume: 17, Issue:4 Topics: Acidosis, Lactic; Adamantane; Adenosine Triphosphate; Alkynes; Animals; Cytokines; Disease Models, A	2013
[Neuroprotective mechanism of hydrogen sulfide after cerebral ischemia-reperfusion in rats]. Zhonghua yi xue za zhi, 2013, Mar-19, Volume: 93, Issue:11 Topics: Animals; Brain Ischemia; HSP20 Heat-Shock Proteins; Hydrogen Sulfide; Male; Neurons; Neuroprotective	2013
Hydrogen sulfide preconditioning protects rat liver against ischemia/reperfusion injury by activating Akt-GSK-3β signaling and inhibiting mitochondrial permeability transition. PloS one, 2013, Volume: 8, Issue:9 Topics: Animals; Apoptosis; Aspartate Aminotransferases; Calcium; Caspase 3; Caspase 9; Cytochromes c; Enzym	2013
Hydrogen sulfide mitigates reperfusion injury in a porcine model of vascularized composite autotransplantation. Annals of plastic surgery, 2014, Volume: 72, Issue:5 Topics: Allografts; Animals; Aspartate Aminotransferases; Biomarkers; Cytokines; Disease Models, Animal; Gra	2014
Hydrogen sulfide protected gastric epithelial cell from ischemia/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-κB dependent anti-inflammation pathway. European journal of pharmacology, 2014, Feb-15, Volume: 725 Topics: Active Transport, Cell Nucleus; Apoptosis; Cell Line; Cell Nucleus; Cytoprotection; Epithelial Cells	2014
Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia. Journal of molecular neuroscience : MN, 2014, Volume: 54, Issue:2 Topics: Animals; Apoptosis; Brain; Edema; Hydrogen Sulfide; Infarction, Middle Cerebral Artery; Male; Neurop	2014
Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts. Pharmacological reports : PR, 2014, Volume: 66, Issue:3 Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antioxidants; Arrhythmias, C	2014
mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection. PloS one, 2014, Volume: 9, Issue:6 Topics: Animals; Cardiotonic Agents; Chromones; Humans; Hydrogen Sulfide; Mechanistic Target of Rapamycin Co	2014
H₂S protecting against lung injury following limb ischemia-reperfusion by alleviating inflammation and water transport abnormality in rats. Biomedical and environmental sciences : BES, 2014, Volume: 27, Issue:6 Topics: Acute Lung Injury; Animals; Aquaporins; Drug Evaluation, Preclinical; Edema; Hydrogen Sulfide; Infla	2014
Hydrogen sulfide ameliorates ischemia/reperfusion-induced hepatitis by inhibiting apoptosis and autophagy pathways. Mediators of inflammation, 2014, Volume: 2014 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Beclin-1;	2014
Signaling of hydrogen sulfide and polysulfides. Antioxidants & redox signaling, 2015, Feb-10, Volume: 22, Issue:5 Topics: Animals; Gasotransmitters; Humans; Hydrogen Sulfide; Inflammation; Reperfusion Injury; Signal Transd	2015
Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S. Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:5 Topics: Animals; Beta vulgaris; Blotting, Western; Hydrogen Sulfide; Male; Mice; Myocardial Infarction; Poly	2015
The role of miR-34a in the hepatoprotective effect of hydrogen sulfide on ischemia/reperfusion injury in young and old rats. PloS one, 2014, Volume: 9, Issue:11 Topics: Age Factors; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Cells, C	2014
Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats. Annals of vascular surgery, 2015, Volume: 29, Issue:2 Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Constriction; Disease Mode	2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell, 2015, Jan-15, Volume: 160, Issue:1-2 Topics: Animals; Biological Evolution; Caenorhabditis elegans; Caloric Restriction; Cystathionine gamma-Lyas	2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell, 2015, Jan-15, Volume: 160, Issue:1-2 Topics: Animals; Biological Evolution; Caenorhabditis elegans; Caloric Restriction; Cystathionine gamma-Lyas	2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell, 2015, Jan-15, Volume: 160, Issue:1-2 Topics: Animals; Biological Evolution; Caenorhabditis elegans; Caloric Restriction; Cystathionine gamma-Lyas	2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell, 2015, Jan-15, Volume: 160, Issue:1-2 Topics: Animals; Biological Evolution; Caenorhabditis elegans; Caloric Restriction; Cystathionine gamma-Lyas	2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell, 2015, Jan-15, Volume: 160, Issue:1-2 Topics: Animals; Biological Evolution; Caenorhabditis elegans; Caloric Restriction; Cystathionine gamma-Lyas	2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell, 2015, Jan-15, Volume: 160, Issue:1-2 Topics: Animals; Biological Evolution; Caenorhabditis elegans; Caloric Restriction; Cystathionine gamma-Lyas	2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell, 2015, Jan-15, Volume: 160, Issue:1-2 Topics: Animals; Biological Evolution; Caenorhabditis elegans; Caloric Restriction; Cystathionine gamma-Lyas	2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell, 2015, Jan-15, Volume: 160, Issue:1-2 Topics: Animals; Biological Evolution; Caenorhabditis elegans; Caloric Restriction; Cystathionine gamma-Lyas	2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell, 2015, Jan-15, Volume: 160, Issue:1-2 Topics: Animals; Biological Evolution; Caenorhabditis elegans; Caloric Restriction; Cystathionine gamma-Lyas	2015
Sirtuin 6 is essential for sodium sulfide-mediated cytoprotective effect in ischemia/reperfusion-stimulated brain endothelial cells. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2015, Volume: 24, Issue:3 Topics: Animals; Antioxidants; Brain Ischemia; Catalase; Cell Death; Cell Hypoxia; Cell Line; Cystathionine	2015
Impact of endogenous hydrogen sulfide on toll-like receptor pathway in renal ischemia/reperfusion injury in rats. Renal failure, 2015, Volume: 37, Issue:4 Topics: Animals; Hydrogen Sulfide; Kidney; Male; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury;	2015
Attenuation of inflammatory responses by hydrogen sulfide (H₂S) in ischemia/reperfusion injury. Methods in enzymology, 2015, Volume: 555 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular System; Central Nervous System; Cyt	2015
Hydrogen sulphide as a novel therapy to ameliorate cyclosporine nephrotoxicity. The Journal of surgical research, 2015, Volume: 197, Issue:2 Topics: Animals; Calcineurin Inhibitors; Cyclosporine; Female; Hydrogen Sulfide; Kidney; Protective Agents;	2015
The effect of a hydrogen sulfide releasing molecule (Na2S) on the cold storage of livers from cardiac dead donor rats. A study in an ex vivo model. Cryobiology, 2015, Volume: 71, Issue:1 Topics: Animals; Cryopreservation; Cytoprotection; Glucose; Heme Oxygenase-1; Hydrogen Sulfide; Ischemia; Li	2015
Hydrogen sulfide protects spinal cord and induces autophagy via miR-30c in a rat model of spinal cord ischemia-reperfusion injury. Journal of biomedical science, 2015, Jul-07, Volume: 22 Topics: Animals; Autophagy; Gene Expression Regulation; Humans; Hydrogen Sulfide; MicroRNAs; Neuroprotective	2015
ROS-Dependent Neuroprotective Effects of NaHS in Ischemia Brain Injury Involves the PARP/AIF Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 36, Issue:4 Topics: Animals; Antioxidants; Brain; Brain Injuries; Brain Ischemia; Cell Line; Hydrogen Sulfide; Male; Neu	2015
Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation. The Journal of urology, 2015, Volume: 194, Issue:6 Topics: Allografts; Animals; Cell Line, Tumor; Cell Survival; Cold Ischemia; Disease Models, Animal; Graft S	2015
Hydrogen sulphide and mild hypothermia activate the CREB signaling pathway and prevent ischemia-reperfusion injury. BMC anesthesiology, 2015, Aug-18, Volume: 15 Topics: Analysis of Variance; Animals; Blotting, Western; Brain Injuries; Brain Ischemia; Brain-Derived Neur	2015
Mild Hypothermia Combined with Hydrogen Sulfide Treatment During Resuscitation Reduces Hippocampal Neuron Apoptosis Via NR2A, NR2B, and PI3K-Akt Signaling in a Rat Model of Cerebral Ischemia-Reperfusion Injury. Molecular neurobiology, 2016, Volume: 53, Issue:7 Topics: Animals; Apoptosis; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; Hippocampus;	2016
Reducing Ischemia-Reperfusion Injury in Renal Transplantation. The Journal of urology, 2015, Volume: 194, Issue:6 Topics: Animals; Cold Ischemia; Disease Models, Animal; Graft Survival; Hydrogen Sulfide; Kidney Transplanta	2015
Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway. Brain research bulletin, 2016, Volume: 121 Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Inhalation; Animals; Brain Infarction; Deoxyguanosine;	2016
Hydrogen sulfide post-conditioning preserves interfibrillar mitochondria of rat heart during ischemia reperfusion injury. Cell stress & chaperones, 2016, Volume: 21, Issue:4 Topics: Animals; Cardiotonic Agents; Creatine Kinase; Electron Transport; Electron Transport Chain Complex P	2016
Hydrogen Sulfide, a Potential Cardioprotective Gas Activating a Life Span Regulator. International heart journal, 2016, Jul-27, Volume: 57, Issue:4 Topics: Animals; Biomarkers; Cardiotonic Agents; Disease Models, Animal; Evidence-Based Medicine; Humans; Hy	2016
Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury. Scientific reports, 2016, 07-29, Volume: 6 Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Hydrogen Sulfide; Lung; Microbubbles; Myocar	2016
Controlled release hydrogen sulfide delivery system based on mesoporous silica nanoparticles protects graft endothelium from ischemia-reperfusion injury. International journal of nanomedicine, 2016, Volume: 11 Topics: Allyl Compounds; Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Delayed-Action Prepar	2016
Silymarin preconditioning protected insulin resistant rats from liver ischemia-reperfusion injury: role of endogenous H2S. The Journal of surgical research, 2016, Volume: 204, Issue:2 Topics: Animals; Antioxidants; Apoptosis; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Drug Evalu	2016
Effects of hydrogen sulfide on cognitive dysfunction and NR2B in rats. The Journal of surgical research, 2016, Volume: 205, Issue:2 Topics: Animals; Biomarkers; Blotting, Western; Cognitive Dysfunction; Drug Administration Schedule; Hippoca	2016
Protecting the Mitochondria Against Ischemia Reperfusion: A Gassy Solution? American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017, Volume: 17, Issue:2 Topics: Delayed Graft Function; Humans; Hydrogen Sulfide; Kidney Transplantation; Mitochondria; Reperfusion	2017
Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations. Molecules (Basel, Switzerland), 2017, Feb-15, Volume: 22, Issue:2 Topics: Animals; Biomarkers; Disease Models, Animal; Disease Progression; Gastric Mucosa; Gene Expression; H	2017
Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:2 Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Cytoprotection;	2008
Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction. Laboratory investigation; a journal of technical methods and pathology, 2008, Volume: 88, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cystathionine gamma-Lyase; Disease Models, Animal; Hyd	2008
Hydrogen sulfide triggers late-phase preconditioning in postischemic small intestine by an NO- and p38 MAPK-dependent mechanism. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Cell Adhesion; Disease Models, Animal; Enzyme Inhibitors; Hydroge	2009
Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:2 Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione Peroxidase; Hydrogen Sulfide; Intestinal	2009
Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study. European journal of pharmacology, 2009, Mar-15, Volume: 606, Issue:1-3 Topics: Animals; Cystathionine gamma-Lyase; Gene Expression Regulation; Hydrogen Sulfide; Kidney; Male; Mice	2009
Ischemia-reperfusion reduces cystathionine-beta-synthase-mediated hydrogen sulfide generation in the kidney. American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:1 Topics: Animals; Apoptosis; Cyclic N-Oxides; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease	2009
Hydrogen sulfide-induced hypometabolism prevents renal ischemia/reperfusion injury. Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:9 Topics: Adaptation, Physiological; Air Pollutants; Animals; Disease Models, Animal; Energy Metabolism; Hiber	2009
ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture. Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:1 Topics: Animals; Blotting, Western; Caspases; Cells, Cultured; Disease Models, Animal; Electrophoresis, Poly	2010
Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2009, Volume: 15, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cystathionine gamma-Lyase; Hydrogen Sulfide; I	2009
Hydrogen sulfide protects against ischemia-reperfusion injury in an in vitro model of cutaneous tissue transplantation. The Journal of surgical research, 2010, Volume: 159, Issue:1 Topics: 3T3 Cells; Animals; Cytoprotection; Endothelial Cells; Fibroblasts; Humans; Hydrogen Sulfide; Mice;	2010
Hydrogen sulphide ameliorates ischaemia-reperfusion injury in an experimental model of non-heart-beating donor kidney transplantation. The British journal of surgery, 2010, Volume: 97, Issue:2 Topics: Acid-Base Equilibrium; Animals; Biomarkers; Dinoprost; Dose-Response Relationship, Drug; Hemodynamic	2010
Effect of hydrogen sulfide on myocardial protection in the setting of cardioplegia and cardiopulmonary bypass. Interactive cardiovascular and thoracic surgery, 2010, Volume: 10, Issue:4 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Cardiopulmonary Bypass; Cardiotonic Ag	2010
Hypoxia in the renal medulla: implications for hydrogen sulfide signaling. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:2 Topics: Animals; Humans; Hydrogen Sulfide; Hypertension; Hypoxia; Kidney; Kidney Medulla; Oxygen; Renal Insu	2010
Dynamic change of hydrogen sulfide during global cerebral ischemia-reperfusion and its effect in rats. Brain research, 2010, Jul-23, Volume: 1345 Topics: Animals; Blotting, Western; Brain Ischemia; Central Nervous System Agents; Cerebral Cortex; Cystathi	2010
Hydrogen sulfide attenuates ischemia-reperfusion injury in in vitro and in vivo models of intestine free tissue transfer. Plastic and reconstructive surgery, 2010, Volume: 125, Issue:6 Topics: Animals; Cell Line; Cell Survival; Cytoprotection; Disease Models, Animal; Enterocytes; Hydrogen Sul	2010
Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia/reperfusion injury. Shock (Augusta, Ga.), 2011, Volume: 35, Issue:2 Topics: Air Pollutants; Animals; Aorta; bcl-X Protein; Caspase 3; Creatinine; Energy Metabolism; Female; Glo	2011
Hydrogen sulfide attenuates intestinal ischemia-reperfusion injury when delivered in the post-ischemic period. Journal of gastroenterology and hepatology, 2010, Volume: 25, Issue:10 Topics: Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen Sulfide	2010
Hydrogen sulphide attenuates renal and cardiac injury after total hepatic ischemia and reperfusion. The Journal of surgical research, 2010, Volume: 164, Issue:2 Topics: Animals; Cell Adhesion Molecules; Enzyme-Linked Immunosorbent Assay; Hepatic Artery; Hydrogen Sulfid	2010
H2S protects hippocampal neurons from anoxia-reoxygenation through cAMP-mediated PI3K/Akt/p70S6K cell-survival signaling pathways. Journal of molecular neuroscience : MN, 2011, Volume: 43, Issue:3 Topics: Air Pollutants; Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cyclic AMP; Hippocampus;	2011
[Protection of CSE/H2S system in hepatic ischemia reperfusion injury in rats]. Zhonghua wai ke za zhi [Chinese journal of surgery], 2010, Jun-15, Volume: 48, Issue:12 Topics: Animals; Apoptosis; Cystathionine gamma-Lyase; Disease Models, Animal; Hydrogen Sulfide; Interleukin	2010
Therapeutic metabolic inhibition: hydrogen sulfide significantly mitigates skeletal muscle ischemia reperfusion injury in vitro and in vivo. Plastic and reconstructive surgery, 2010, Volume: 126, Issue:6 Topics: Administration, Inhalation; Animals; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; H	2010
Hydrogen sulfide attenuates ischemia-reperfusion injury in in vitro and in vivo models of intestine free tissue transfer. Plastic and reconstructive surgery, 2011, Volume: 127, Issue:1 Topics: Animals; Hydrogen Sulfide; In Vitro Techniques; Intestines; Reperfusion Injury; Surgical Flaps	2011
Delivery of the bioactive gas hydrogen sulfide during cold preservation of rat liver: effects on hepatic function in an ex vivo model. Artificial organs, 2011, Volume: 35, Issue:5 Topics: Adenosine; Allopurinol; Allyl Compounds; Animals; Bile; Cold Ischemia; Disulfides; Gases; Glutathion	2011
Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia/reperfusion injury. Molecular vision, 2011, Volume: 17 Topics: Administration, Inhalation; Animals; Apoptosis; Caspase Inhibitors; Cell Death; DNA; Female; Glial F	2011
Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of heme oxygenase-1. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:3 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Cell Adhesion; Disease Models, Animal; Dose	2011
Emerging roles for gasotransmitters. Experimental physiology, 2011, Volume: 96, Issue:9 Topics: Carbon Monoxide; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Humans; Hydrogen Sulfide; I	2011
Hydrogen sulfide preconditioning or neutrophil depletion attenuates ischemia-reperfusion-induced mitochondrial dysfunction in rat small intestine. American journal of physiology. Gastrointestinal and liver physiology, 2012, Jan-01, Volume: 302, Issue:1 Topics: Animals; Benzimidazoles; Cytochromes c; Hydrogen Sulfide; Intestinal Diseases; Intestine, Small; Isc	2012
[Exogenous hydrogen sulfide attenuates gastric ischemia-reperfusion injury via activation of K(ATP) channel]. Sheng li xue bao : [Acta physiologica Sinica], 2012, Feb-25, Volume: 64, Issue:1 Topics: Animals; Gastric Mucosa; Hydrogen Sulfide; Ischemic Preconditioning; KATP Channels; Male; Rats; Rats	2012
Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation. The Journal of surgical research, 2012, Volume: 178, Issue:1 Topics: Animals; Blood Pressure; Disease Models, Animal; Hydrogen Sulfide; Lung Transplantation; Perfusion;	2012
Hydrogen sulfide decreases the levels of ROS by inhibiting mitochondrial complex IV and increasing SOD activities in cardiomyocytes under ischemia/reperfusion. Biochemical and biophysical research communications, 2012, May-04, Volume: 421, Issue:2 Topics: Animals; Cells, Cultured; Cytoprotection; Electron Transport Complex IV; Hydrogen Sulfide; Mitochond	2012
Solubility and permeation of hydrogen sulfide in lipid membranes. PloS one, 2012, Volume: 7, Issue:4 Topics: Animals; Cell Membrane; Diffusion; Hexanes; Hydrogen Sulfide; Mice; Octanols; Permeability; Phosphol	2012
Protective role of methionine sulfoxide reductase A against ischemia/reperfusion injury in mouse kidney and its involvement in the regulation of trans-sulfuration pathway. Antioxidants & redox signaling, 2013, Jun-10, Volume: 18, Issue:17 Topics: Animals; Antigens, Ly; Disease Models, Animal; Enzyme Activation; Gene Deletion; Gene Expression Reg	2013
The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia/reperfusion injury in mice. Autophagy, 2012, Volume: 8, Issue:6 Topics: Animals; Autophagy; Cytokines; Cytoprotection; Hepatocytes; Hydrogen Sulfide; Inflammation Mediators	2012
Beneficial effects of gaseous hydrogen sulfide in hepatic ischemia/reperfusion injury. Transplant international : official journal of the European Society for Organ Transplantation, 2012, Volume: 25, Issue:8 Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Hydrogen Sulfide; Male; Mice;	2012
Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation. The Journal of surgical research, 2012, Volume: 178, Issue:2 Topics: Administration, Inhalation; Animals; Cyclic AMP; Electron Transport Complex IV; Hydrogen Sulfide; Lu	2012
A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. The Journal of biological chemistry, 2012, Sep-14, Volume: 287, Issue:38 Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Cell Line, Tumor; Cells, Cultured; Drug Design;	2012
Dual effects of hydrogen sulphide on focal cerebral ischaemic injury via modulation of oxidative stress-induced apoptosis. Clinical and experimental pharmacology & physiology, 2012, Volume: 39, Issue:9 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Infarction; Brain Ischemia; Cerebral Cortex	2012
Detrimental effects of prolonged warm renal ischaemia-reperfusion injury are abrogated by supplemental hydrogen sulphide: an analysis using real-time intravital microscopy and polymerase chain reaction. BJU international, 2012, Volume: 110, Issue:11 Pt C Topics: Animals; Biomarkers; Dietary Supplements; Disease Models, Animal; Hydrogen Sulfide; Kidney; Kidney T	2012
Inhibition of hydrogen sulfide generation contributes to lung injury after experimental orthotopic lung transplantation. The Journal of surgical research, 2013, Jun-01, Volume: 182, Issue:1 Topics: Alkynes; Animals; Cold Ischemia; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Hydrogen Sul	2013
Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats. Brain research, 2013, Jan-23, Volume: 1491 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Biomarkers; Blotting, Wes	2013
Effects of hydrogen sulphide in an experimental model of renal ischaemia-reperfusion injury. The British journal of surgery, 2012, Volume: 99, Issue:12 Topics: Acute Kidney Injury; Animals; Biomarkers; Constriction; Creatinine; Disease Models, Animal; Female;	2012
Supplemental hydrogen sulphide protects transplant kidney function and prolongs recipient survival after prolonged cold ischaemia-reperfusion injury by mitigating renal graft apoptosis and inflammation. BJU international, 2012, Volume: 110, Issue:11 Pt C Topics: Animals; Apoptosis; Dietary Supplements; Disease Models, Animal; Graft Survival; Hydrogen Sulfide; I	2012
[Alternation of thioredoxin system in postconditioning with hydrogen sulfide against hepatic ischemia-reperfusion injury in rats]. Zhonghua yi xue za zhi, 2012, Oct-09, Volume: 92, Issue:37 Topics: Animals; Hydrogen Sulfide; Ischemic Postconditioning; Liver; Male; Rats; Rats, Sprague-Dawley; Reper	2012
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. Nature communications, 2013, Volume: 4 Topics: Animals; Biosynthetic Pathways; Brain; Cells, Cultured; Cysteine; Cytoprotection; D-Amino-Acid Oxida	2013
A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium. Toxicology, 2007, Nov-20, Volume: 241, Issue:1-2 Topics: Air Pollutants; Animals; Apoptosis; ATP-Binding Cassette Transporters; Bisbenzimidazole; Cell Death;	2007
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, 2007, Sep-25, Volume: 104, Issue:39 Topics: Animals; Apoptosis; Echocardiography; Heart Ventricles; Hydrogen Sulfide; Inflammation; Male; Mice;	2007
Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels. Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:12 Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Cells, Cultured; Glyburide; Heart; Hydrogen Sulfi	2007
Hemodynamic and metabolic effects of hydrogen sulfide during porcine ischemia/reperfusion injury. Shock (Augusta, Ga.), 2008, Volume: 30, Issue:4 Topics: Animals; Aorta; Carbon Dioxide; Female; Glucose; Hemodynamics; Hydrogen Sulfide; Lactates; Male; Mit	2008
Effects of hydrogen sulphide on ischaemia-reperfusion injury and ischaemic preconditioning in the isolated, perfused rat heart. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:2 Topics: Animals; Blotting, Western; Cardiotonic Agents; Drug Evaluation, Preclinical; HSP72 Heat-Shock Prote	2008
Hydrogen sulfide protects rat lung from ischemia-reperfusion injury. Life sciences, 2008, Jun-06, Volume: 82, Issue:23-24 Topics: Animals; Cystathionine gamma-Lyase; Free Radicals; Hydrogen Sulfide; In Vitro Techniques; Lung; Lung	2008

hydrogen sulfide and Reperfusion Injury

Research Excerpts

Research

Studies (142)

Authors

Clinical Trials (4)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Scheid, S	1
Goeller, M	1
Baar, W	1
Wollborn, J	1
Buerkle, H	1
Schlunck, G	1
Lagrèze, W	1
Goebel, U	2
Ulbrich, F	1
Hashmi, SF	1
Rathore, HA	2
Sattar, MA	1
Johns, EJ	2
Gan, CY	1
Chia, TY	1
Ahmad, A	1
Wu, D	1
Gu, Y	1
Zhu, D	1
El-Sayed, SS	1
Shahin, RM	1
Fahmy, A	1
Elshazly, SM	1
Yuksel, S	1
Erginel, B	1
Bingul, I	1
Ozluk, Y	1
Karatay, H	1
Aydın, F	1
Keskin, E	1
Deng, G	1
Muqadas, M	1
Adlat, S	1
Zheng, H	2
Li, G	3
Zhu, P	1
Nasser, MI	1
Omorou, M	2
Liu, N	1
Huang, Y	2
Al-Ward, H	1
Gao, M	2
Mu, C	2
Zhang, L	1
Hui, X	1
Wang, F	2
Zhou, H	1
Zhang, X	1
Emre Aydıngöz, S	1
Teimoori, A	1
Orhan, HG	1
Efe, OE	1
Kibaroğlu, S	1
Erdem, ŞR	1
Yan, J	1
Zhang, B	1
Yu, J	1
Wang, X	1
Zhao, H	2
Yin, Y	1
Meng, C	1
McFarlane, L	1
Nelson, P	1
Dugbartey, GJ	4
Sener, A	9
Xu, W	1
Xu, H	1
Press, AT	1
Ungelenk, L	1
Medyukhina, A	1
Pennington, SA	1
Nietzsche, S	1
Kan, C	1
Lupp, A	1
Dahmen, U	1
Wang, R	4
Settmacher, U	1
Wetzker, R	1
Figge, MT	1
Clemens, MG	1
Bauer, M	1
Zheng, W	1
Liu, C	1
Soo, E	1
Welch, A	1
Marsh, C	1
McKay, DB	1
Cui, N	1
Luo, H	2
Zhao, Y	1
Krylatov, A	1
Maslov, L	1
Tsibulnikov, SY	1
Voronkov, N	1
Boshchenko, A	1
Downey, J	1
Mentzer, R	1
Wijerathne, CUB	1
Madduma Hewage, S	1
Siow, YL	2
O, K	2
Luo, Y	1
Liu, LM	1
Xie, L	2
Zhao, HL	1
Lu, YK	1
Wu, BQ	1
Wu, ZY	1
Zhang, ZL	1
Hao, YL	1
Ou, WH	1
Liu, RS	1
Xu, WM	1
Chen, XH	1
Zhang, MY	2
Juriasingani, S	4
Ling, Q	1
Yu, X	1
Wang, T	1
Wang, SG	1
Ye, ZQ	1
Liu, JH	1
Yu, S	1
Yang, K	1
Li, C	1
Liang, Y	1
Bouma, HR	1
Saha, MN	1
Lobb, I	4
Henning, RH	1
Sekijima, M	1
Sahara, H	1
Miki, K	1
Villani, V	1
Ariyoshi, Y	1
Iwanaga, T	1
Tomita, Y	1
Yamada, K	1
Woo, CW	1
Kwon, JI	1
Kim, KW	1
Kim, JK	1
Jeon, SB	1
Jung, SC	1
Choi, CG	1
Kim, ST	1
Kim, J	1
Ham, SJ	1
Shim, WH	1
Sung, YS	1
Ha, HK	1
Choi, Y	1
Woo, DC	1
Wolf, A	1
Lusczek, ER	1
Beilman, GJ	1
Xin, L	1
Junhua, W	1
Long, L	1
Jun, Y	1
Yang, X	1
Hashmp, SF	1
Sattar, MZA	1
Ahmadi, A	1
Liu, Y	6
Pan, L	1
Jiang, A	1
Yin, M	1
Choi, EK	1
Park, SH	1
Lim, JA	1
Hong, SW	1
Kwak, KH	1
Park, SS	1
Lim, DG	1
Jung, H	1
Khodosovskii, MN	1
Woods, JJ	1
Cao, J	1
Lippert, AR	1
Wilson, JJ	1
Akbari, M	1
Chan, JY	1
Whiteman, M	2
Drucker, NA	1
Jensen, AR	1
Te Winkel, JP	1
Markel, TA	1
Kakinohana, M	1
Marutani, E	2
Tokuda, K	2
Kida, K	2
Kosugi, S	2
Kasamatsu, S	1
Magliocca, A	1
Ikeda, K	1
Kai, S	1
Sakaguchi, M	1
Hirai, S	1
Xian, M	1
Kaneki, M	1
Ichinose, F	2
Wetzel, MD	1
Wenke, JC	1
Jiang, T	1
Meng, Q	1
Lv, X	1
Yue, Z	1
Ding, W	1
Liu, T	1
Cui, X	1
Zhu, C	1
Su, Y	1
Veramkovich, V	1
Jiang, J	1
Lacefield, J	1
Nagpal, D	1
Alotaibi, F	1
Liu, K	1
Zheng, X	1
Ball, CJ	1
Reiffel, AJ	1
Chintalapani, S	1
Kim, M	1
Spector, JA	5
King, MR	1
Bos, EM	3
Snijder, PM	3
Boersema, M	1
Damman, J	1
Fu, M	1
Moser, J	1
Hillebrands, JL	3
Ploeg, RJ	1
Yang, G	1
Leuvenink, HG	3
van Goor, H	3
Han, J	1
Chen, ZW	1
He, GW	1
Wang, WZ	1
Jones, AW	1
Wang, M	2
Durante, W	2
Korthuis, RJ	4
Qin, H	1
Gu, LZ	1
Gao, L	1
Guo, J	1
Issa, K	1
Kimmoun, A	1
Collin, S	1
Ganster, F	1
Fremont-Orlowski, S	1
Asfar, P	2
Mertes, PM	1
Levy, B	1
Yin, J	2
Zeng, QH	1
Shen, Q	1
Yang, XS	1
Zhang, Q	1
Fu, H	1
Zhang, H	3
Xu, F	1
Zou, Z	1
Liu, M	1
Wang, Q	3
Miao, M	1
Shi, X	1
Villamaria, CY	1
Fries, CA	1
Spencer, JR	1
Roth, M	1
Davis, MR	1
Guo, C	3
Liang, F	1
Shah Masood, W	1
Yan, X	1
Gheibi, S	1
Aboutaleb, N	1
Khaksari, M	1
Kalalian-Moghaddam, H	1
Vakili, A	1
Asadi, Y	1
Mehrjerdi, FZ	1
Gheibi, A	1
Dudek, M	1
Knutelska, J	1
Bednarski, M	1
Nowiński, L	1
Zygmunt, M	1
Bilska-Wilkosz, A	1
Iciek, M	1
Otto, M	1
Żytka, I	1
Sapa, J	1
Włodek, L	1
Filipek, B	1
Zhou, Y	2
Wang, D	2
Gao, X	1
Lew, K	1
Richards, AM	1
Wang, P	1
Qi, QY	1
Chen, W	1
Li, XL	1
Wang, YW	1
Xie, XH	1
Cheng, P	1
Chen, K	1
Shen, M	1
Dai, W	1
Xu, L	1
Zhang, Y	2
Wang, C	2
Li, J	1
Yang, J	1
Zhu, R	1
Zheng, Y	1
Lu, J	1
Kimura, H	3
Salloum, FN	1
Sturz, GR	1
Yin, C	1
Rehman, S	1
Hoke, NN	1
Kukreja, RC	1
Xi, L	1
Huang, X	1
Gao, Y	1
Qin, J	1
Lu, S	1
Hunter, JP	2
Hosgood, SA	4
Patel, M	2
Furness, P	1
Sayers, RD	1
Nicholson, ML	4
Hine, C	1
Harputlugil, E	1
Ruckenstuhl, C	1
Lee, BC	1
Brace, L	1
Longchamp, A	1
Treviño-Villarreal, JH	1
Mejia, P	1
Ozaki, CK	1
Gladyshev, VN	1
Madeo, F	1
Mair, WB	1
Mitchell, JR	1
Hu, Y	1
Li, R	2
Yang, H	1
Chen, Z	1
Tan, Z	1
Shi, Y	1
Yan, Y	1
Liu, W	3
Sodha, NR	1
Sellke, FW	2
Bełtowski, J	3
Lee, G	1
Patel, MS	1
Balaban, CL	2
Rodríguez, JV	2
Tiribelli, C	1
Guibert, EE	2
Azizi, F	1
Seifi, B	1
Kadkhodaee, M	1
Ahghari, P	1
Li, L	1
Jiang, HK	1
Li, YP	1
Guo, YP	1
Yu, Q	1
Lu, Z	1
Tao, L	2
Yang, L	2
Guo, Y	1
Yang, Y	1
Sun, X	4
Ding, Q	1
Davison, M	2
Carter, D	1
Haig, A	1
Gunaratnam, L	1
Dai, HB	2
Ji, X	1
Zhu, SH	2
Hu, YM	1
Zhang, LD	1
Miao, XL	2
Ma, RM	2
Duan, ML	2
Li, WY	1
Xu, MM	1
Lv, J	1
Ji, XJ	1
Ko, DS	1
Rovcanin, B	1
Medic, B	1
Kocic, G	1
Cebovic, T	1
Ristic, M	1
Prostran, M	1
Ji, K	1
Xue, L	1
Cheng, J	1
Bai, Y	1
Banu, SA	1
Ravindran, S	1
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