hydrogen sulfide has been researched along with Pulmonary Disease, Chronic Obstructive in 22 studies
Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.
Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Results have been conflicting whether long-term ambient hydrogen sulfide (H2S) affects lung function or is a risk factor for asthma or chronic obstructive pulmonary disease (COPD)." | 7.81 | Investigation of hydrogen sulfide exposure and lung function, asthma and chronic obstructive pulmonary disease in a geothermal area of New Zealand. ( Balmes, JR; Bates, MN; Crane, J; Garrett, N, 2015) |
| "Airway inflammation was classified in 77 COPD subjects based on the presence of inflammatory cells in induced sputum." | 5.42 | Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD. ( Chen, Y; Wang, X; Yao, W; Zhang, J, 2015) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "A panel of 23 stable COPD patients was repeatedly measured for biomarkers of airway inflammation including exhaled nitric oxide (FeNO) and exhaled hydrogen sulfide (FeH2S) (215 measurements) and recorded for daily respiratory symptoms (794person-days) in two study periods in Beijing, China in January-September 2014." | 3.83 | Short-term exposure to high ambient air pollution increases airway inflammation and respiratory symptoms in chronic obstructive pulmonary disease patients in Beijing, China. ( Baccarelli, AA; Chen, Y; Deng, F; Guo, X; Li, H; Ni, Y; Pan, L; Shima, M; Wu, S; Yang, D, 2016) |
| "Results have been conflicting whether long-term ambient hydrogen sulfide (H2S) affects lung function or is a risk factor for asthma or chronic obstructive pulmonary disease (COPD)." | 3.81 | Investigation of hydrogen sulfide exposure and lung function, asthma and chronic obstructive pulmonary disease in a geothermal area of New Zealand. ( Balmes, JR; Bates, MN; Crane, J; Garrett, N, 2015) |
| "Chronic obstructive pulmonary disease (COPD) is a significant public health problem but it is unclear whether agricultural work causes an increased risk of disease." | 2.55 | Chronic Obstructive Pulmonary Disease in Farmers: A Systematic Review. ( Capitanelli, I; Fontana, L; Iavicoli, I; Lee, SJ; Maniscalco, M; Mauriello, MC; Re, A, 2017) |
| "Inflammation is a response to traumatic, infectious, post-ischemic, toxic, or autoimmune injury." | 2.52 | H2S and Inflammation: An Overview. ( Bhatia, M, 2015) |
| "Chronic Obstructive Pulmonary Disease (COPD) was defined according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD)." | 1.91 | Exposure to low levels of hydrogen sulphide and its impact on chronic obstructive pulmonary disease and lung function in the geothermal area of Mt. Amiata in Italy: The cross-sectional InVETTA study. ( Barbone, F; Centi, L; Crocetti, E; Nisticò, F; Nuvolone, D; Petri, D; Stoppa, G; Voller, F, 2023) |
| "Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, which is usually caused by exposure to noxious particles or gases." | 1.72 | The Protective Role of Hydrogen Sulfide and Its Impact on Gene Expression Profiling in Rat Model of COPD. ( Chen, Y; He, Y; Liao, C; Lin, F; Qi, Y; Sun, Y; Xia, Z, 2022) |
| "Patients with chronic obstructive pulmonary disease and non-alcoholic steatohepatitis, which developed against the background of obesity, are characterized by a significant increase in the synthesis of collagen and glycoproteins, which was accompanied by an ineffective resorption of newly formed collagen against the background of substantial activation of proteinase inhibitors (α2-MG), accompanied by the hyperproduction of nitrogen monoxide, endothelin-1, hyperlipidemia, deficiency of hydrogen sulfide liberation." | 1.51 | The role of hydrogen sulfide in the progression of chronic obstructive pulmonary disease in patients with non-alcoholic steatohepatitis ( Dudka, IV; Dudka, TV; Hryniuk, OY; Khukhlina, OS; Kovalenko, SV; Mandry, OY, 2019) |
| "COPD is a common, highly debilitating disease of the airways, primarily caused by smoking." | 1.48 | The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide. ( Adcock, I; Caramori, G; Casolari, P; Chung, KF; Halayko, AJ; Papi, A; Perry, MM; Rempel, KL; Tildy, B, 2018) |
| "Current COPD therapy involving anticholinergics, β2-adrenoceptor agonists and/or corticosteroids, do not specifically target oxidative stress, nor do they reduce chronic pulmonary inflammation and disease progression in all patients." | 1.43 | The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease. ( Bos, IS; Graaf, AC; Halayko, AJ; Han, B; Henning, RH; Krenning, G; Maarsingh, H; Meurs, H; Poppinga, WJ; Schmidt, M; Smit, M; Stienstra, S; van Vliet, B; Vogelaar, P; Zuidhof, AB; Zuo, H, 2016) |
| "Airway inflammation was classified in 77 COPD subjects based on the presence of inflammatory cells in induced sputum." | 1.42 | Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD. ( Chen, Y; Wang, X; Yao, W; Zhang, J, 2015) |
| "Hydrogen sulfide (H2S ) has been implicated in the pathogenesis of COPD, but its expression and effects in lung tissue from COPD patients are not clear." | 1.42 | Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity. ( Chang, JR; Chen, YH; He, W; Li, MX; Liao, CC; Lin, F; Qi, YF; Sun, Y; Wang, K; Wang, R, 2015) |
| "Hydrogen sulfide (H₂S) is a gas produced by respiratory cells including smooth muscle cells and may play a role as a cellular gasotransmitter." | 1.40 | Sputum-to-serum hydrogen sulfide ratio in COPD. ( Bhavsar, PK; Chung, KF; Gibeon, D; Macedo, P; Mackay, AJ; Rossios, C; Saito, J; Sinharay, R; Wedzicha, JA, 2014) |
| "Within the COPD group, patients with Anthonisen type 1 exacerbations had a lower serum H(2)S concentration (22." | 1.35 | Serum hydrogen sulfide as a novel marker predicting bacterial involvement in patients with community-acquired lower respiratory tract infections. ( Chen, YH; Gao, JZ; Geng, B; Tang, CS; Wang, PP; Yao, WZ, 2009) |
| "(4) AECOPD with pulmonary hypertension pulmonary artery systolic pressure (PASP) > or = 35 mm Hg (1 mm Hg = 0." | 1.33 | [Endogenous hydrogen sulfide in patients with chronic obstructive pulmonary disease]. ( Chen, YH; Ding, YL; Geng, B; Lu, M; Tang, CS; Yao, WZ; Zhao, MW, 2005) |
| "Patients with AECOPD had arterial blood gas levels measured and underwent Doppler echocardiography." | 1.33 | Endogenous hydrogen sulfide in patients with COPD. ( Chen, YH; Ding, YL; Geng, B; Lu, M; Tang, CS; Yao, WZ; Zhao, MW, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 5 (22.73) | 2.80 |
| Authors | Studies |
|---|---|
| He, Y | 1 |
| Sun, Y | 4 |
| Liao, C | 1 |
| Lin, F | 3 |
| Xia, Z | 1 |
| Qi, Y | 1 |
| Chen, Y | 3 |
| Stoppa, G | 1 |
| Nuvolone, D | 1 |
| Petri, D | 1 |
| Centi, L | 1 |
| Nisticò, F | 1 |
| Crocetti, E | 1 |
| Barbone, F | 1 |
| Voller, F | 1 |
| Khukhlina, OS | 1 |
| Hryniuk, OY | 1 |
| Dudka, IV | 1 |
| Kovalenko, SV | 1 |
| Dudka, TV | 1 |
| Mandry, OY | 1 |
| Wang, L | 1 |
| Meng, J | 1 |
| Wang, C | 1 |
| Yang, C | 1 |
| Wang, Y | 1 |
| Li, Y | 2 |
| Suzuki, Y | 1 |
| Saito, J | 2 |
| Munakata, M | 1 |
| Shibata, Y | 1 |
| Fontana, L | 1 |
| Lee, SJ | 1 |
| Capitanelli, I | 1 |
| Re, A | 1 |
| Maniscalco, M | 1 |
| Mauriello, MC | 1 |
| Iavicoli, I | 1 |
| Perry, MM | 1 |
| Tildy, B | 1 |
| Papi, A | 1 |
| Casolari, P | 1 |
| Caramori, G | 2 |
| Rempel, KL | 1 |
| Halayko, AJ | 2 |
| Adcock, I | 1 |
| Chung, KF | 3 |
| Wang, XM | 1 |
| Chen, YH | 7 |
| Zhu, RX | 1 |
| Liao, CC | 3 |
| Kirkham, PA | 1 |
| Whiteman, M | 1 |
| Winyard, PG | 1 |
| Gordon, F | 1 |
| Ford, PA | 1 |
| Barnes, PJ | 1 |
| Adcock, IM | 1 |
| Mackay, AJ | 1 |
| Rossios, C | 1 |
| Gibeon, D | 1 |
| Macedo, P | 1 |
| Sinharay, R | 1 |
| Bhavsar, PK | 1 |
| Wedzicha, JA | 1 |
| Zhang, J | 1 |
| Wang, X | 1 |
| Yao, W | 1 |
| Bates, MN | 1 |
| Crane, J | 1 |
| Balmes, JR | 1 |
| Garrett, N | 1 |
| Bhatia, M | 1 |
| Wang, K | 1 |
| Li, MX | 2 |
| He, W | 1 |
| Chang, JR | 1 |
| Qi, YF | 2 |
| Wang, R | 1 |
| Wu, S | 1 |
| Ni, Y | 1 |
| Li, H | 1 |
| Pan, L | 1 |
| Yang, D | 1 |
| Baccarelli, AA | 1 |
| Deng, F | 1 |
| Shima, M | 1 |
| Guo, X | 1 |
| Han, B | 1 |
| Poppinga, WJ | 1 |
| Zuo, H | 1 |
| Zuidhof, AB | 1 |
| Bos, IS | 1 |
| Smit, M | 1 |
| Vogelaar, P | 1 |
| Krenning, G | 1 |
| Henning, RH | 1 |
| Maarsingh, H | 1 |
| van Vliet, B | 1 |
| Stienstra, S | 1 |
| Graaf, AC | 1 |
| Meurs, H | 1 |
| Schmidt, M | 1 |
| Bai, Y | 1 |
| Mi, WJ | 1 |
| Yao, WZ | 4 |
| Gao, JZ | 1 |
| Geng, B | 4 |
| Wang, PP | 1 |
| Tang, CS | 4 |
| Ding, YL | 3 |
| Lu, M | 3 |
| Zhao, MW | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Enhancement of In-vitro GC Function in Patients With COPD. A Randomised, Double Blind, Placebo Controlled, Parallel-group Study to Investigate the Effect of Theophylline and Fluticasone on Induced Sputum Cells Obtained Form COPD Patients[NCT00241631] | Phase 2 | 49 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Interleukin 8 (IL8) assessed from sputum (NCT00241631)
Timeframe: 10 weeks
| Intervention | ng/mL (Mean) |
|---|---|
| Placebo | 33.3 |
| Steroid | 28.3 |
Supernatant collect, cell pellets count on slides (NCT00241631)
Timeframe: 10 weeks
| Intervention | millions cells/ ml (Mean) |
|---|---|
| Placebo | 5.42 |
| Steroid | 3.89 |
Total eosinophils cells assessed from sputum (NCT00241631)
Timeframe: 10 weeks
| Intervention | millions cells/ml (Mean) |
|---|---|
| Placebo | 0.132 |
| Steroid | 0.053 |
4 reviews available for hydrogen sulfide and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Hydrogen sulfide as a novel biomarker of asthma and chronic obstructive pulmonary disease.
Topics: Animals; Asthma; Biomarkers; Humans; Hydrogen Sulfide; Pulmonary Disease, Chronic Obstructive | 2021 |
Chronic Obstructive Pulmonary Disease in Farmers: A Systematic Review.
Topics: Agriculture; Ammonia; Animals; Dairying; Dust; Endotoxins; Humans; Hydrogen Sulfide; Livestock; Mite | 2017 |
H2S and Inflammation: An Overview.
Topics: Animals; Arthritis; Humans; Hydrogen Sulfide; Inflammation; Pancreatitis; Pulmonary Disease, Chronic | 2015 |
3 trials available for hydrogen sulfide and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD.
Topics: Adrenal Cortex Hormones; Biomarkers; Bronchodilator Agents; Disease Progression; Forced Expiratory V | 2014 |
Effect of theophylline on endogenous hydrogen sulfide production in patients with COPD.
Topics: Aged; Blood Cell Count; Bronchodilator Agents; Female; Humans; Hydrogen Sulfide; Interleukin-8; Male | 2008 |
16 other studies available for hydrogen sulfide and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
The Protective Role of Hydrogen Sulfide and Its Impact on Gene Expression Profiling in Rat Model of COPD.
Topics: Animals; Gene Expression Profiling; Hydrogen Sulfide; Microarray Analysis; Pulmonary Disease, Chroni | 2022 |
Exposure to low levels of hydrogen sulphide and its impact on chronic obstructive pulmonary disease and lung function in the geothermal area of Mt. Amiata in Italy: The cross-sectional InVETTA study.
Topics: Adult; Cross-Sectional Studies; Humans; Hydrogen Sulfide; Italy; Lung; Pulmonary Disease, Chronic Ob | 2023 |
The role of hydrogen sulfide in the progression of chronic obstructive pulmonary disease in patients with non-alcoholic steatohepatitis
Topics: Adult; Disease Progression; Humans; Hydrogen Sulfide; Middle Aged; Non-alcoholic Fatty Liver Disease | 2019 |
Hydrogen sulfide alleviates cigarette smoke-induced COPD through inhibition of the TGF-
Topics: Animals; Hydrogen Sulfide; Male; Pulmonary Disease, Chronic Obstructive; Rats, Sprague-Dawley; Signa | 2020 |
The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide.
Topics: Aged; Anti-Inflammatory Agents; Cell Proliferation; Cells, Cultured; Female; Humans; Hydrogen Sulfid | 2018 |
Exhaled hydrogen sulfide in patients with chronic obstructive pulmonary disease and its correlation with exhaled nitric oxide.
Topics: Aged; Breath Tests; Female; Forced Expiratory Volume; Humans; Hydrogen Sulfide; Male; Middle Aged; N | 2013 |
Sputum-to-serum hydrogen sulfide ratio in COPD.
Topics: Aged; Biomarkers; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Hydrogen Sulfid | 2014 |
Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD.
Topics: Aged; Area Under Curve; Biomarkers; Breath Tests; Eosinophilia; Eosinophils; Exhalation; Female; For | 2015 |
Investigation of hydrogen sulfide exposure and lung function, asthma and chronic obstructive pulmonary disease in a geothermal area of New Zealand.
Topics: Adolescent; Adult; Air Pollutants; Asthma; Bronchodilator Agents; Female; Humans; Hydrogen Sulfide; | 2015 |
Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Cystathionine beta-Syn | 2015 |
Short-term exposure to high ambient air pollution increases airway inflammation and respiratory symptoms in chronic obstructive pulmonary disease patients in Beijing, China.
Topics: Aged; Air Pollutants; Air Pollution; Beijing; Biomarkers; Dyspnea; Environmental Exposure; Female; H | 2016 |
The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Line, Transformed; Chromans; Co | 2016 |
[Role and mechanism of hydrogen sulfide in cigarette smoke induced chronic obstructive pulmonary disease related pulmonary vascular remodeling in rats].
Topics: Alkynes; Animals; Glycine; Hydrogen Sulfide; Lung; Male; Nicotiana; Pulmonary Artery; Pulmonary Dise | 2017 |
Serum hydrogen sulfide as a novel marker predicting bacterial involvement in patients with community-acquired lower respiratory tract infections.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Biomarkers; C-Reactive Protein; Case-Control | 2009 |
[Endogenous hydrogen sulfide in patients with chronic obstructive pulmonary disease].
Topics: Aged; Case-Control Studies; Female; Humans; Hydrogen Sulfide; Male; Middle Aged; Nitric Oxide; Pulmo | 2005 |
Endogenous hydrogen sulfide in patients with COPD.
Topics: Aged; Female; Humans; Hydrogen Sulfide; Male; Middle Aged; Nitric Oxide; Pulmonary Disease, Chronic | 2005 |