Page last updated: 2024-10-17

hydrogen sulfide and Hemorrhagic Shock

hydrogen sulfide has been researched along with Hemorrhagic Shock in 18 studies

Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.

Research Excerpts

ExcerptRelevanceReference
" We investigated the role of hydrogen sulfide (H2S) in PHSML drainage in alleviating acute kidney injury (AKI) by administering D,L-propargylglycine (PPG) and sodium hydrosulfide hydrate (NaHS) to 12 specific pathogen-free male Wistar rats with PHSML drainage."7.81Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats. ( Han, B; Li, SG; Niu, CY; Zhang, LM; Zhao, ZG, 2015)
"This study was designed to investigate the protective effects of exogenous hydrogen sulfide (H(2)S) on trauma-hemorrhagic shock (T-H)."7.78Exogenous hydrogen sulfide protects against traumatic hemorrhagic shock via attenuation of oxidative stress. ( Chai, W; Ding, Q; Gao, CJ; Jiang, W; Lin, JY; Sun, XD; Wang, Y; Yang, YH; Yao, LN; Zhao, H, 2012)
"Heart rate increased similarly during hemorrhagic shock in both groups."5.37Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs. ( Bayir, H; Drabek, T; Kochanek, PM; Morhard, RC; Stezoski, J; Stezoski, SW; Tisherman, SA; Wu, X, 2011)
"Hydrogen sulfide (H2S) has been shown to improve survival in rodent models of lethal hemorrhage."5.36Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats. ( Asfar, P; Burban, M; Calès, P; de la Bourdonnaye, M; Douay, O; Fizanne, L; Ganster, F; Henrion, D; Loufrani, L; Mercat, A; Meziani, F; Radermacher, P, 2010)
" We investigated the role of hydrogen sulfide (H2S) in PHSML drainage in alleviating acute kidney injury (AKI) by administering D,L-propargylglycine (PPG) and sodium hydrosulfide hydrate (NaHS) to 12 specific pathogen-free male Wistar rats with PHSML drainage."3.81Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats. ( Han, B; Li, SG; Niu, CY; Zhang, LM; Zhao, ZG, 2015)
"This study was designed to investigate the protective effects of exogenous hydrogen sulfide (H(2)S) on trauma-hemorrhagic shock (T-H)."3.78Exogenous hydrogen sulfide protects against traumatic hemorrhagic shock via attenuation of oxidative stress. ( Chai, W; Ding, Q; Gao, CJ; Jiang, W; Lin, JY; Sun, XD; Wang, Y; Yang, YH; Yao, LN; Zhao, H, 2012)
"The role of the gaseous mediator hydrogen sulfide (H2S) in hemorrhagic shock is still a matter of debate."3.78Endogenous H2S in hemorrhagic shock: innocent bystander or central player? ( Calzia, E; Olson, KR; Radermacher, P, 2012)
"While we focus on hemorrhagic shock, many of the described treatments may be used in other situations of hypoxia or ischemia/reperfusion injury."2.58Hibernation-Based Approaches in the Treatment of Hemorrhagic Shock. ( Beilman, GJ; Lusczek, ER; Wolf, A, 2018)
"Hemorrhagic shock was induced by bleeding the animals."1.48Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks. ( Coskun, CN; Demirel-Yilmaz, E; Savci, V; Usanmaz, SE, 2018)
"Hydrogen sulfide (H2S) has been demonstrated to induce a "suspended animation-like" state in rodent models by reversible inhibition of cellular respiration and marked metabolic suppression and has been proposed as a potential pharmacologic adjunct to resuscitation from shock states."1.42Hydrogen sulfide improves resuscitation via non-hibernatory mechanisms in a porcine shock model. ( DeHart, MJ; Hempel, J; Hoffer, Z; Martin, M; Raywin, H; Salgar, S; Satterly, SA; Stallings, JD; Wingerd, M, 2015)
"Hydrogen sulfide (H2S) has been reported to be interwined in multiple systems, specifically in the cardiovascular system."1.42An exogenous hydrogen sulphide donor, NaHS, inhibits the apoptosis signaling pathway to exert cardio-protective effects in a rat hemorrhagic shock model. ( Dai, X; Gao, C; Wu, C; Xu, X; Xu, Y; Zhu, D, 2015)
" In conclusion, sulfide treatment can be effective in hemorrhagic shock, but its effectiveness is restricted to a narrow timing and dosing window."1.38Effects of intravenous sulfide during resuscitated porcine hemorrhagic shock*. ( Asfar, P; Bracht, H; Calzia, E; Georgieff, M; Gröger, M; Hauser, B; Hoppe, K; Lampl, L; Matallo, J; Matejovic, M; McCook, O; Möller, P; Radermacher, P; Scheuerle, A; Seifritz, A; Simon, F; Stahl, B; Stahl, W; Szabó, C; Vogt, JA; Wachter, U; Wagner, F, 2012)
"Heart rate increased similarly during hemorrhagic shock in both groups."1.37Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs. ( Bayir, H; Drabek, T; Kochanek, PM; Morhard, RC; Stezoski, J; Stezoski, SW; Tisherman, SA; Wu, X, 2011)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (16.67)29.6817
2010's15 (83.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Coskun, CN1
Usanmaz, SE1
Savci, V1
Demirel-Yilmaz, E1
Wolf, A1
Lusczek, ER1
Beilman, GJ1
Haouzi, P2
Issa, K1
Kimmoun, A1
Collin, S1
Ganster, F2
Fremont-Orlowski, S1
Asfar, P3
Mertes, PM1
Levy, B1
Han, B1
Zhao, ZG1
Zhang, LM1
Li, SG1
Niu, CY1
Satterly, SA1
Salgar, S1
Hoffer, Z1
Hempel, J1
DeHart, MJ1
Wingerd, M1
Raywin, H1
Stallings, JD1
Martin, M1
Xu, Y1
Dai, X1
Zhu, D1
Xu, X1
Gao, C2
Wu, C1
Mok, YY2
Moore, PK2
Drabek, T2
Kochanek, PM1
Stezoski, J1
Wu, X1
Bayir, H1
Morhard, RC1
Stezoski, SW1
Tisherman, SA1
Burban, M1
de la Bourdonnaye, M1
Fizanne, L1
Douay, O1
Loufrani, L1
Mercat, A1
Calès, P1
Radermacher, P3
Henrion, D1
Meziani, F1
Chai, W2
Wang, Y1
Lin, JY1
Sun, XD1
Yao, LN2
Yang, YH1
Zhao, H1
Jiang, W1
Gao, CJ2
Ding, Q2
Bracht, H1
Scheuerle, A1
Gröger, M1
Hauser, B1
Matallo, J1
McCook, O1
Seifritz, A1
Wachter, U1
Vogt, JA1
Matejovic, M1
Möller, P1
Calzia, E2
Szabó, C2
Stahl, W1
Hoppe, K1
Stahl, B1
Lampl, L1
Georgieff, M1
Wagner, F1
Simon, F1
Xu, DQ1
Li, ZC1
Van de Louw, A1
Olson, KR1
Atan, MS1
Yoke Ping, C1
Zhong Jing, W1
Bhatia, M1
Moochhala, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hydrogen Sulfide as Prognostic Factor[NCT01088490]50 participants (Actual)Observational2010-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for hydrogen sulfide and Hemorrhagic Shock

ArticleYear
Hibernation-Based Approaches in the Treatment of Hemorrhagic Shock.
    Shock (Augusta, Ga.), 2018, Volume: 50, Issue:1

    Topics: Animals; Hibernation; Humans; Hydrogen Sulfide; Melatonin; Reperfusion Injury; Shock, Hemorrhagic

2018
Hydrogen sulphide and its therapeutic potential.
    Nature reviews. Drug discovery, 2007, Volume: 6, Issue:11

    Topics: Animals; Cardiovascular Diseases; Humans; Hydrogen Sulfide; Inflammation; Motor Activity; Shock, Hem

2007

Other Studies

16 other studies available for hydrogen sulfide and Hemorrhagic Shock

ArticleYear
Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks.
    Inflammation, 2018, Volume: 41, Issue:1

    Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Disease Models, Animal; Endothelial Cel

2018
Tissue hypoxia during acute hemorrhage.
    Critical care (London, England), 2013, Mar-28, Volume: 17, Issue:2

    Topics: Animals; Hydrogen Sulfide; Hypoxia; Oxygen; Shock, Hemorrhagic

2013
Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury.
    Critical care (London, England), 2013, Jul-10, Volume: 17, Issue:4

    Topics: Acidosis, Lactic; Adamantane; Adenosine Triphosphate; Alkynes; Animals; Cytokines; Disease Models, A

2013
Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:7

    Topics: Acute Kidney Injury; Alkynes; Animals; Creatinine; Cystathionine gamma-Lyase; Cytokines; Drainage; E

2015
Hydrogen sulfide improves resuscitation via non-hibernatory mechanisms in a porcine shock model.
    The Journal of surgical research, 2015, Volume: 199, Issue:1

    Topics: Acidosis; Animals; Biomarkers; Cardiac Output; Combined Modality Therapy; Homeostasis; Hydrogen Sulf

2015
An exogenous hydrogen sulphide donor, NaHS, inhibits the apoptosis signaling pathway to exert cardio-protective effects in a rat hemorrhagic shock model.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:6

    Topics: Animals; Apoptosis; Blotting, Western; Cardiotonic Agents; Disease Models, Animal; Heart; Hemodynami

2015
Hydrogen sulphide is pro-inflammatory in haemorrhagic shock.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2008, Volume: 57, Issue:11

    Topics: Alkynes; Animals; Blood Pressure; Glycine; Heart Rate; Hydrogen Sulfide; Inflammation; Interleukin-1

2008
Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs.
    Shock (Augusta, Ga.), 2011, Volume: 35, Issue:1

    Topics: Animals; Cardiac Output; Heart Rate; Hydrogen Sulfide; Hypothermia; Male; Oxygen Consumption; Random

2011
Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats.
    Critical care (London, England), 2010, Volume: 14, Issue:5

    Topics: Animals; Hemodynamics; Hydrogen Sulfide; Inflammation Mediators; Male; Oxidative Stress; Random Allo

2010
Exogenous hydrogen sulfide protects against traumatic hemorrhagic shock via attenuation of oxidative stress.
    The Journal of surgical research, 2012, Volume: 176, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Heart; Hemodynamics; Hydrogen Sulfide; Kidney; Liver; Lun

2012
Hydrogen sulfide-curiouser and curiouser!*.
    Critical care medicine, 2012, Volume: 40, Issue:7

    Topics: Female; Humans; Hydrogen Sulfide; Male; Resuscitation; Shock, Hemorrhagic

2012
Effects of intravenous sulfide during resuscitated porcine hemorrhagic shock*.
    Critical care medicine, 2012, Volume: 40, Issue:7

    Topics: Bilirubin; Creatinine; Female; Humans; Hydrogen Sulfide; Hydroxyethyl Starch Derivatives; Infusions,

2012
An exogenous hydrogen sulphide donor, NaHS, inhibits the nuclear factor κB inhibitor kinase/nuclear factor κb inhibitor/nuclear factor-κB signaling pathway and exerts cardioprotective effects in a rat hemorrhagic shock model.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:7

    Topics: Animals; Cardiotonic Agents; Creatine Kinase; Disease Models, Animal; Hydrogen Sulfide; I-kappa B Ki

2012
Oxygen deficit and H2S in hemorrhagic shock in rats.
    Critical care (London, England), 2012, Oct-02, Volume: 16, Issue:5

    Topics: Animals; Hydrogen Sulfide; Hypoxia; Inhalation; Oxygen; Rats; Rats, Sprague-Dawley; Shock, Hemorrhag

2012
Endogenous H2S in hemorrhagic shock: innocent bystander or central player?
    Critical care (London, England), 2012, Nov-29, Volume: 16, Issue:6

    Topics: Animals; Hydrogen Sulfide; Hypoxia; Oxygen; Shock, Hemorrhagic

2012
Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis.
    British journal of pharmacology, 2004, Volume: 143, Issue:7

    Topics: Alanine; Alkynes; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Cystathionine gamma-Ly

2004