Page last updated: 2024-10-17

hydrogen sulfide and Down Syndrome

hydrogen sulfide has been researched along with Down Syndrome in 10 studies

Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.

Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Research Excerpts

ExcerptRelevanceReference
"Mental retardation is progressive in Down syndrome: individuals are born with normal intelligence which starts to decline linearly within the first year."5.31Mental retardation in Down syndrome: a hydrogen sulfide hpothesis. ( Kamoun, P, 2001)
" Chronic administration of CSE inhibitor induces arterial hypertension in the rat."2.42[Hydrogen sulfide as a biologically active mediator in the cardiovascular system]. ( Bełtowski, J, 2004)
"Prenatal treatment of Down syndrome fetuses is also suggested."1.51Mental retardation in Down syndrome: Two ways to treat. ( Kamoun, PP, 2019)
"Mental retardation is progressive in Down syndrome: individuals are born with normal intelligence which starts to decline linearly within the first year."1.31Mental retardation in Down syndrome: a hydrogen sulfide hpothesis. ( Kamoun, P, 2001)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (50.00)29.6817
2010's2 (20.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Kamoun, PP1
Panagaki, T2
Randi, EB2
Augsburger, F2
Szabo, C4
Zuhra, K1
Majtan, T1
Kamoun, P4
Belardinelli, MC2
Chabli, A2
Lallouchi, K1
Chadefaux-Vekemans, B2
Bełtowski, J1

Reviews

4 reviews available for hydrogen sulfide and Down Syndrome

ArticleYear
The re-emerging pathophysiological role of the cystathionine-β-synthase - hydrogen sulfide system in Down syndrome.
    The FEBS journal, 2020, Volume: 287, Issue:15

    Topics: Animals; Cystathionine beta-Synthase; Down Syndrome; Energy Metabolism; Humans; Hydrogen Sulfide; Ox

2020
Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition.
    Biomolecules, 2020, 04-30, Volume: 10, Issue:5

    Topics: Animals; Cystathionine beta-Synthase; Down Syndrome; Enzyme Inhibitors; Humans; Hydrogen Sulfide; Ne

2020
Endogenous production of hydrogen sulfide in mammals.
    Amino acids, 2004, Volume: 26, Issue:3

    Topics: Alzheimer Disease; Animals; Down Syndrome; Enzymes; Humans; Hydrogen Sulfide

2004
[Hydrogen sulfide as a biologically active mediator in the cardiovascular system].
    Postepy higieny i medycyny doswiadczalnej (Online), 2004, Jul-19, Volume: 58

    Topics: Alzheimer Disease; Animals; Brain; Cardiovascular System; Cyclic AMP; Cystathionine beta-Synthase; D

2004

Other Studies

6 other studies available for hydrogen sulfide and Down Syndrome

ArticleYear
Mental retardation in Down syndrome: Two ways to treat.
    Medical hypotheses, 2019, Volume: 131

    Topics: Aminooxyacetic Acid; Animals; Benserazide; Brain; Chromosomes, Human, Pair 21; Cobamides; Cystathion

2019
Overproduction of H
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 09-17, Volume: 116, Issue:38

    Topics: Aminooxyacetic Acid; Cell Proliferation; Cells, Cultured; Cystathionine beta-Synthase; Down Syndrome

2019
Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts.
    Biomolecules, 2020, 04-23, Volume: 10, Issue:4

    Topics: Cell Proliferation; Child; Child, Preschool; Cysteine; Down Syndrome; Energy Metabolism; Female; Fib

2020
Endogenous hydrogen sulfide overproduction in Down syndrome.
    American journal of medical genetics. Part A, 2003, Jan-30, Volume: 116A, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Down Syndrome; Female; Humans; Hydrogen Sulfide; I

2003
Urinary sulfur compounds in Down syndrome.
    Clinical chemistry, 2001, Volume: 47, Issue:8

    Topics: Adult; Cystine; Down Syndrome; Female; Humans; Hydrogen Sulfide; Male; Sulfur Compounds; Taurine; Th

2001
Mental retardation in Down syndrome: a hydrogen sulfide hpothesis.
    Medical hypotheses, 2001, Volume: 57, Issue:3

    Topics: Down Syndrome; Humans; Hydrogen Sulfide; Infant; Infant, Newborn; Intellectual Disability; Intellige

2001