hydrogen sulfide has been researched along with Disease Models, Animal in 339 studies
Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the changes of hydrogen sulfide (H(2)S) in vascular tissues of rats with septic shock and endotoxin shock and its possible pathophysiological implication." | 9.10 | Changes in arterial hydrogen sulfide (H(2)S) content during septic shock and endotoxin shock in rats. ( Bin, G; Du, J; Hui, Y; Jiang, H; Tang, C, 2003) |
| " In this study, the effect of fetal hypothyroidism on impairment of aortic vasorelaxation responses in adulthood was investigated with emphasis on possible involvement of hydrogen sulfide (H2S)/nitric oxide interaction." | 8.02 | Fetal Hypothyroidism Impairs Aortic Vasorelaxation Responses in Adulthood: Involvement of Hydrogen Sulfide and Nitric Oxide Cross talk. ( Baluchnejadmojarad, T; Nourabadi, D; Ramazi, S; Roghani, M; Serenjeh, MN; Zarch, SMM, 2021) |
| "This study evaluates the effect of the slow releasing hydrogen sulfide donor GYY4137 (GYY) on neointimal formation in vivo." | 7.96 | The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in mice. ( Grambow, E; Klar, E; Klee, G; Vollmar, B, 2020) |
| "Atorvastatin significantly ameliorated renal dysfunction and morphological changes in CIAKI rats, as well as inflammation, apoptosis, and excessive oxidative stress." | 7.96 | Atorvastatin protects against contrast-induced acute kidney injury via upregulation of endogenous hydrogen sulfide. ( Jiaqiong, L; Ming, L; Xiaoyong, L; Xinxue, L; Xuexian, T; Yan, L; Yinglan, L; Yue, G; Zena, H, 2020) |
| "Hydrogen sulfide donors can block the cardiovascular injury of hyperhomocysteinemia." | 7.91 | Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S-sulfhydration in ApoE-knockout atherosclerotic mice. ( Cai, J; Cui, C; Cui, Q; Fan, J; Geng, B; Jiang, S; Li, S; Tang, X; Xu, G; Yang, J; Zhang, J; Zheng, F, 2019) |
| "In this study, the vitamin D3 plus nicotine (VDN) model of rats was used to prove that H2S alleviates vascular calcification (VC) and phenotype transformation of vascular smooth muscle cells (VSMC)." | 7.83 | Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress. ( Guo, Q; Li, H; Teng, X; Wu, YM; Xiao, L; Xue, HM; Yang, R, 2016) |
| "Hydrogen sulfide (H2S) is an attractive agent for myocardial ischemia-reperfusion injury, however, systemic delivery of H2S may cause unwanted side effects." | 7.83 | Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury. ( Bin, J; Cao, S; Chen, G; Cui, K; Huang, Q; Kutty, S; Liao, W; Liao, Y; Wang, Y; Wu, J; Xiu, J; Yang, L; Zhang, W; Zhong, L, 2016) |
| "The effects of hydrogen sulfide (H2S) on blood-brain barrier (BBB) and brain edema after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) remain poorly understood." | 7.81 | Hydrogen sulfide inhalation decreases early blood-brain barrier permeability and brain edema induced by cardiac arrest and resuscitation. ( Cheng, L; Geng, Y; Li, E; Li, H; Mu, Q; Wei, X; Zhang, B; Zhang, Y, 2015) |
| "During a course of colitis, production of the gaseous mediator hydrogen sulfide (H2S) is markedly up-regulated at sites of mucosal damage and contributes significantly to healing and resolution of inflammation." | 7.81 | Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α. ( Agbor, TA; Buret, AG; Ferraz, JG; Flannigan, KL; Motta, JP; Wallace, JL; Wang, R, 2015) |
| "The discovery of carbon monoxide (CO) and hydrogen sulfide (H2S) as pathogenic signaling molecules in airway-related diseases has led to significant insights into the pathophysiologic mechanisms underlying the development of allergic rhinitis (AR)." | 7.81 | Impact of carbon monoxide/heme oxygenase on hydrogen sulfide/cystathionine-γ-lyase pathway in the pathogenesis of allergic rhinitis in guinea pigs. ( Che, N; Ge, R; Yan, Z; Yu, S; Zhang, X, 2015) |
| "Hydrogen sulfide (H2S) plays multiple roles in the function of the central nervous system in physiological and pathological conditions, such as cerebral ischemia." | 7.81 | Effect of the Inhibition of Hydrogen Sulfide Synthesis on Ischemic Injury and Oxidative Stress Biomarkers in a Transient Model of Focal Cerebral Ischemia in Rats. ( Bandegi, AR; Hadadha, M; Vakili, A, 2015) |
| "This study is to determine the therapeutic effects of Panax notoginseng saponins (PNSs) on coxsackievirus B3 (CVB3)-induced myocarditis, and whether cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S) pathway is involved." | 7.81 | Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway. ( Chu, M; Geng, Z; Jia, L; Lu, J; Pan, L; Rong, X; Wang, Z; Wu, R; Zhang, C; Zhang, Y; Zhao, Q, 2015) |
| "Acute pulmonary edema (APE) is one of the fatal outcomes after exposure to high levels of hydrogen sulfide (H2S), available evidence suggest that dexamethasone (DXM), a potent anti-inflammatory agent, has been widely used or proposed as a therapeutic approach for H2S-induced APE in clinical practice, however, the underlying mechanism remains poorly understood." | 7.80 | α-ENaC, a therapeutic target of dexamethasone on hydrogen sulfide induced acute pulmonary edema. ( Chen, J; Jiang, L; Qian, W; Su, C; Wang, J; Xiao, H; Zhang, H; Zhang, J; Zhu, B, 2014) |
| "To assess the protective effect of exogenous hydrogen sulfide (H₂S) against myocardial injury after skeletal muscle ischemia/reperfusion (IR) in rats and explore the mechanism." | 7.79 | [Exogenous hydrogen sulfide protects against myocardial injury after skeletal muscle ischemia/reperfusion by inhibiting inflammatory cytokines and oxidative stress in rats]. ( Chen, W; Deng, Z; Li, X; Liu, N; Qi, Y; Xie, X; Yang, J; Zhang, Y, 2013) |
| " The goal of the present study was to determine the therapeutic potential of a stable, long-acting H2S donor, diallyl trisulfide, in a model of pressure-overload heart failure and to assess the effects of chronic H2S therapy on myocardial vascular density and angiogenesis." | 7.79 | Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis. ( Bhushan, S; Bir, SC; Calvert, JW; Kevil, CG; Kondo, K; Lefer, DJ; Murohara, T; Polhemus, D, 2013) |
| "The aim of this study was to determine whether thioredoxin 1 (Trx1) mediates the cardioprotective effects of hydrogen sulfide (H2S) in a model of ischemic-induced heart failure (HF)." | 7.79 | Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. ( Calvert, JW; Lambert, JP; Molkentin, JD; Nicholson, CK; Sadoshima, J, 2013) |
| "The role of hydrogen sulfide (H2 S) in inflammation remains unclear with both pro- and anti-inflammatory actions of this gas described." | 7.79 | The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. ( Fox, B; Keeble, J; Li, L; Moore, PK; Salto-Tellez, M; Whiteman, M; Winyard, PG; Wood, ME, 2013) |
| "Hydrogen sulfide (H(2) S), generated by enzymes such as cystathionine-γ-lyase (CSE) from L-cysteine, facilitates pain signals by activating the Ca(v) 3." | 7.78 | Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice. ( Hayashi, Y; Kawabata, A; Kubo, L; Matsunami, M; Miki, T; Nishikawa, H; Nishiura, K; Okawa, Y; Ozaki, T; Sekiguchi, F; Tsujiuchi, T, 2012) |
| "Hydrogen sulfide (H(2)S) is a novel gaseous mediator that plays important roles in atherosclerosis." | 7.78 | Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice. ( Fan, Y; Gu, T; Guo, C; Sparatore, A; Wang, C; Wu, D; Zhang, A; Zhang, H, 2012) |
| "To investigate the interaction between hydrogen sulfide (H2S)/cystathionine gamma-lyase (CSE) system and nitric oxide (NO)/nitric oxide synthase (NOS) system on cardiac protection in metabolic syndrome (MS) rats." | 7.77 | Interaction between hydrogen sulfide and nitric oxide on cardiac protection in rats with metabolic syndrome. ( Gang, H; Ling-qiao, L; Rong-na, L; Xiang-jun, Z; Yu-han, C, 2011) |
| "In vitro (enterocyte anoxia-normoxia) and in vivo (rat intestinal ischemia-reperfusion) models of ischemia-reperfusion injury were tested with or without the addition of hydrogen sulfide." | 7.76 | Hydrogen sulfide attenuates ischemia-reperfusion injury in in vitro and in vivo models of intestine free tissue transfer. ( Henderson, PW; Nagineni, V; Singh, SP; Spector, JA; Sung, J; Weinstein, AL, 2010) |
| "To investigate whether pharmacologic post-conditioning of intestinal tissue with hydrogen sulfide (HS) protects against ischemia reperfusion injury (IRI)." | 7.76 | Hydrogen sulfide attenuates intestinal ischemia-reperfusion injury when delivered in the post-ischemic period. ( Henderson, PW; Jimenez, N; Krijgh, DD; Sohn, AM; Spector, JA; Weinstein, AL, 2010) |
| "Endogenous hydrogen sulfide (H(2)S) is hypothesized to have an important role in systemic inflammation." | 7.75 | Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma. ( Chen, YH; Geng, B; Qi, YF; Tang, CS; Wang, PP; Wu, R; Yao, WZ, 2009) |
| "To explore the role of hydrogen sulfide/cystathionine-gamma-lyase (H(2)S/CSE) system in lipopolysaccharide (LPS)- induced acute lung injury (ALI) in rats and the underlying mechanisms." | 7.75 | [Role of hydrogen sulfide/cystathionine-gamma-lyase system in acute lung injury induced by lipopolysaccharide in rats]. ( Huang, XL; Ling, YL; Tian, FJ; Wei, P; Zhou, XH, 2009) |
| "Elevated level of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), is associated with end-stage renal diseases." | 7.75 | Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure. ( Abe, OA; Basu, P; Givvimani, S; Metreveli, N; Passmore, JC; Sen, U; Shah, KS; Tyagi, N; Tyagi, SC, 2009) |
| "The animal model of acute lung injury (ALI) caused by intravenous injection of lipopolysaccharides (LPS) and cultured human peripheral blood polymorphonuclear neutrophil (PMN) were used to study the effects of sodium hydrosulfide (NaHS), hydrogen sulfide (H2S) donor, on LPS-induced PMN accumulation, microvascular permeability and PMN apoptosis." | 7.75 | [Role of polymorphonuclear neutrophil in exogenous hydrogen sulfide attenuating endotoxin-induced acute lung injury]. ( Ding, CH; Huang, XL; Xian, XH; Zhou, JL; Zhou, XH, 2009) |
| "The role of hydrogen sulfide (H(2)S) in myocardial infarction (MI) has not been previously studied." | 7.74 | Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats. ( Ho, P; Huang, SH; Loke, YY; Lu, J; Moore, PK; Tan, CS; Wang, ZJ; Whiteman, M; Zhu, YC; Zhu, YZ, 2007) |
| "Mesalamine is the first-line therapy for colitis, but it lacks potency and is only effective for mild-to-moderate forms of this disease." | 7.74 | Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. ( Caliendo, G; Cirino, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Orlandi, S; Santagada, V; Santucci, L; Wallace, JL, 2007) |
| "To study the changes of endogenous hydrogen sulfide (H(2)S) and the effect of exogenously applied H(2)S on ovalbumin-induced acute asthma." | 7.74 | [The regulatory effect of endogenous hydrogen sulfide on acute asthma]. ( Chen, YH; Geng, B; Lu, M; Tang, CS; Wu, R; Yao, WZ, 2007) |
| "Cysteine is known to cause neuronal cell death and has been reported to be elevated in brain ischemia, but it has not been studied in clinical stroke." | 7.73 | High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide. ( Chang, HM; Chen, CP; Chimon, GN; Halliwell, B; Ng, YK; Qu, K; Rumpel, H; Seah, AB; Wong, MC; Wong, PT, 2006) |
| "To explore the impact of hydrogen sulfide (H2S) donor, sodium hydrosulfide (NaHS), on pulmonary vascular structure and vasoactive peptides in rats with pulmonary hypertension induced by high pulmonary blood flow." | 7.73 | [Impact of hydrogen sulfide donor on pulmonary vascular structure and vasoactive peptides in rats with pulmonary hypertension induced by high pulmonary blood flow]. ( Du, JB; Li, XH; Tang, CS, 2006) |
| "Hypertension is a major risk factor for intimal hyperplasia (IH) and re-stenosis following vascular and endovascular interventions." | 5.72 | Hydrogen Sulphide Release via the Angiotensin Converting Enzyme Inhibitor Zofenopril Prevents Intimal Hyperplasia in Human Vein Segments and in a Mouse Model of Carotid Artery Stenosis. ( Allagnat, F; Corpataux, JM; Déglise, S; Deslarzes-Dubuis, C; Lambelet, M; Longchamp, A; Macabrey, D; Ozaki, CK, 2022) |
| "Sepsis often leads to multiple organ failure or even death and is a significant health problem that contributes to a heavy economic burden." | 5.72 | Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury. ( Li, J; Li, L; Li, M; Ma, J; Yao, C; Yao, S, 2022) |
| "Glaucoma is a neurodegenerative disease of visual system characterized by gradual loss of retinal ganglion cells (RGC)." | 5.72 | Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model. ( Chen, J; Huang, P; Huang, S; Liu, X; Shen, X; Wang, J; Yu, H; Zhong, Y, 2022) |
| "Hydrogen sulfide (H2S) has drawn considerable attention in recent years for its potential as a cardiovascular protector." | 5.56 | Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway. ( Ling, X; Sun, J; Wang, P; Xi, W; Xiao, J; Xue, X; Yang, Q, 2020) |
| "Glaucoma is a group of neurodegenerative eye diseases characterized by progressive impairment of visual function due to loss of retinal ganglion cells (RGC)." | 5.48 | Hydrogen sulfide supplement attenuates the apoptosis of retinal ganglion cells in experimental glaucoma. ( Guo, L; Huang, P; Huang, S; Li, C; Lin, Z; Liu, X; Shen, X; Xu, X; Zhong, Y, 2018) |
| "Hydrogen sulfide has been recognized as an important neuroprotective agent in the nervous system." | 5.48 | Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat. ( Jiang, A; Liu, Y; Pan, L; Yin, M, 2018) |
| "Hydrogen sulfide (H2S) is an essential neuromodulator, generates by cystathionine β synthase (CBS) or 3-mecaptopyruvate sulfurtransferase (3MST) in the brain." | 5.48 | Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis. ( Cai, J; Cui, C; Cui, Q; Geng, B; Han, J; Lu, H; Tang, C; Xu, G; Yang, J; Zheng, F; Zhou, Y, 2018) |
| "Hydrogen sulfide (H2S) has anti‑inflammatory and neuroprotective properties, particularly during pathological processes." | 5.46 | Hydrogen sulfide protects against the development of experimental cerebral malaria in a C57BL/6 mouse model. ( Han, Z; Huang, J; Jiang, P; Lun, Z; Xiao, B; Xu, J; Xu, Z; Zhou, W, 2017) |
| "Autophagy is upregulated in spinal cord ischemia reperfusion (SCIR) injury; however, its expression mechanism is largely unknown; moreover, whether autophagy plays a neuroprotective or neurodegenerative role in SCIR injury remains controversial." | 5.46 | Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury. ( Li, C; Liang, Y; Xie, L; Yang, K; Yu, S, 2017) |
| "Glaucoma is an irreversible and blinding neurodegenerative disease of the eye, and is characterized by progressive loss of retinal ganglion cells (RGCs)." | 5.46 | Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model. ( Guo, L; Huang, P; Huang, S; Leung, CK; Lin, Z; Liu, X; Wang, J; Xu, S; Zhong, Y, 2017) |
| "During resuscitated septic shock in swine with CAD, GYY4137 shifted metabolism to preferential carbohydrate utilization." | 5.46 | Metabolic, Cardiac, and Renal Effects of the Slow Hydrogen Sulfide-Releasing Molecule GYY4137 During Resuscitated Septic Shock in Swine with Pre-Existing Coronary Artery Disease. ( Calzia, E; Georgieff, M; Gröger, M; Hafner, S; Matallo, J; McCook, O; Nußbaum, BL; Radermacher, P; Vogt, J; Wachter, U; Wepler, M; Whiteman, M; Wood, ME, 2017) |
| "We investigated whether mild hypothermia combined with sodium hydrosulfide treatment during resuscitation improves neuron survival following cerebral ischemia-reperfusion injury beyond that observed for the individual treatments." | 5.43 | Mild Hypothermia Combined with Hydrogen Sulfide Treatment During Resuscitation Reduces Hippocampal Neuron Apoptosis Via NR2A, NR2B, and PI3K-Akt Signaling in a Rat Model of Cerebral Ischemia-Reperfusion Injury. ( Dai, HB; Duan, ML; Ji, XJ; Lv, J; Ma, RM; Miao, XL; Xu, MM; Zhu, SH, 2016) |
| "Obesity was found to be associated with decreased vessel H2S concentration, inward hypertrophic remodeling, altered collagen-to-elastin ratio, and reduced vessel stiffness." | 5.43 | Hydrogen sulfide depletion contributes to microvascular remodeling in obesity. ( Candela, J; Velmurugan, GV; White, C, 2016) |
| "Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule with significant pathophysiological importance, but its role in retinal neovascular diseases is unknown." | 5.43 | Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy. ( Coletta, C; Gersztenkorn, D; Ha, Y; Liu, H; Motamedi, M; Szabo, C; Tie, H; Zhang, W; Zhou, J; Zhu, S, 2016) |
| "Hydrogen sulfide (H2S) has been shown to exert cardioprotective effects in MI." | 5.43 | Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages. ( Miao, L; Moore, PK; Shen, X; Shen, Y; Whiteman, M; Xin, H; Xin, X; Zhu, YZ, 2016) |
| "In the mice with cerulein-induced acute pancreatitis, the referred hyperalgesia was suppressed by NNC 55-0396 (NNC), a selective T-channel inhibitor; zinc chloride; or ascorbic acid, known to inhibit Ca(v)3." | 5.42 | Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis. ( Fujimura, M; Kawabata, A; Nishimura, S; Sekiguchi, F; Terada, Y; Tsubota, M, 2015) |
| "Hydrogen sulfide is a mediator of IRI and can ameliorate tissue injury in many organ systems." | 5.42 | Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats. ( Furness, P; Hosgood, SA; Hunter, JP; Nicholson, ML; Patel, M; Sayers, RD, 2015) |
| "Rats underwent 2-h middle cerebral artery occlusion (MCAO) and received 40 ppm or 80 ppm H2S inhalation for 3h at the beginning of reperfusion." | 5.42 | Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC. ( Cheng, L; Chi, M; Deng, L; Pan, H; Wang, G; Wei, X; Yao, X; Zhang, B, 2015) |
| "Ischemia-reperfusion injury is unavoidable during organ transplantation." | 5.42 | Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation. ( Carter, D; Davison, M; Gunaratnam, L; Haig, A; Liu, W; Lobb, I; Sener, A, 2015) |
| "Hydrogen sulfide has recently been found decreased in chronic kidney disease." | 5.40 | Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy. ( Hu, LF; Li, Q; Liu, CF; Peng, H; Shen, HY; Shi, YB; Song, K; Wang, F; Zheng, HF, 2014) |
| "Hydrogen sulfide (H2S) is a toxic gas now being recognized as an endogenous signaling molecule in multiple organ systems, in particular, the cardiovascular system." | 5.40 | Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis. ( Dong, M; Hu, N; Ren, J, 2014) |
| "Hydrogen sulfide (H2 S) is a potent vasodilator and regulates cardiovascular homeostasis." | 5.40 | Hydrogen sulfide treatment induces angiogenesis after cerebral ischemia. ( Choi, IY; Jang, H; Kim, YJ; Lee, SH; Oh, MY; Ryu, WS; Yang, HS; Yoon, BW, 2014) |
| "Hydrogen sulfide (H2S) is an important gaseous signaling agent mediated by many physiological processes and diseases." | 5.40 | Inorganic-organic hybrid nanoprobe for NIR-excited imaging of hydrogen sulfide in cell cultures and inflammation in a mouse model. ( Chen, W; Huang, L; Huang, W; Loo, JS; Pei, W; Wang, C; Yan, Q; Yao, C; Zhang, Q; Zhou, Y; Zhu, J, 2014) |
| "Hydrogen sulfide has been demonstrated to be a critical mediator of gastric and intestinal mucosal protection and repair." | 5.40 | Cytoprotective effects of hydrogen sulfide in novel rat models of non-erosive esophagitis. ( Bula, N; Grushka, O; Havryluk, O; Hrycevych, N; Wallace, JL; Zayachkivska, O, 2014) |
| "The exact etiology of preeclampsia is unknown, but there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation." | 5.39 | Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia. ( Ahmad, S; Ahmed, A; Baily, J; Buhimschi, CS; Buhimschi, IA; Cai, M; Crispi, F; Cudmore, M; Fujisawa, T; Gratacós, E; Hadoke, PW; Miller, MR; Rennie, J; Wang, K; Wang, R, 2013) |
| "Depression is a common and debilitating mental illness and is often comorbid with anxiety disorders." | 5.39 | Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in behavioral models of depression and anxiety. ( Chen, WL; Hu, B; Niu, YY; Tang, XQ; Tian, Y; Xie, B; Xu, KL; Zhang, C; Zhang, P; Zou, W, 2013) |
| "Hydrogen sulfide (H(2)S) is a gaseous neuromodulator endogenously produced in the brain by the enzyme cystathionine β-synthase (CBS)." | 5.39 | Hydrogen sulfide inhibits preoptic prostaglandin E2 production during endotoxemia. ( Araujo, RM; Azevedo, LU; Batalhao, ME; Branco, LG; Carnio, EC; Coimbra, TM; Francescato, HD; Kwiatkoski, M; Soriano, RN, 2013) |
| "In septic rats pretreated with AOAA, sepsis-associated hippocampus inflammation was reduced." | 5.37 | Effects of hydrogen sulfide on a rat model of sepsis-associated encephalopathy. ( Chen, D; Lan, X; Li, C; Liu, B; Pan, H; Yang, G, 2011) |
| "Hydrogen sulfide (H(2)S) is a gaseous messenger and serves as an important neuromodulator in central nervous system." | 5.36 | Dynamic change of hydrogen sulfide during global cerebral ischemia-reperfusion and its effect in rats. ( Du, A; Li, D; Mayhan, WG; Ren, C; Sui, J; Zhao, H, 2010) |
| "Hydrogen sulfide (H(2)S) is an endogenously produced gaseous signaling molecule with diverse physiological activity." | 5.35 | Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling. ( Calvert, JW; Duranski, MR; Jha, S; Lefer, DJ; Ramachandran, A, 2008) |
| "Hydrogen sulfide (H2S) is an endogenously gaseous mediator, regulating many pathophysiological functions in mammalian cells." | 5.35 | Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. ( Bai, XB; Cao, YX; Liu, H; Shi, S, 2009) |
| "Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator of mucosal defense with antiinflammatory effects that promote ulcer healing." | 5.35 | Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. ( Dicay, M; Martin, GR; McKnight, W; Vong, L; Wallace, JL, 2009) |
| "Hydrogen sulfide (H2S) is a naturally occurring gaseous transmitter, which may play important roles in normal physiology and disease." | 5.33 | Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. ( Anuar, FB; Bhatia, M; Collin, M; Moore, PK; Murch, O; Thiemermann, C, 2005) |
| "To explore the changes of hydrogen sulfide (H(2)S) in vascular tissues of rats with septic shock and endotoxin shock and its possible pathophysiological implication." | 5.10 | Changes in arterial hydrogen sulfide (H(2)S) content during septic shock and endotoxin shock in rats. ( Bin, G; Du, J; Hui, Y; Jiang, H; Tang, C, 2003) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| " In this study, the effect of fetal hypothyroidism on impairment of aortic vasorelaxation responses in adulthood was investigated with emphasis on possible involvement of hydrogen sulfide (H2S)/nitric oxide interaction." | 4.02 | Fetal Hypothyroidism Impairs Aortic Vasorelaxation Responses in Adulthood: Involvement of Hydrogen Sulfide and Nitric Oxide Cross talk. ( Baluchnejadmojarad, T; Nourabadi, D; Ramazi, S; Roghani, M; Serenjeh, MN; Zarch, SMM, 2021) |
| "It was found that chronic and acute uses of both propargylglycine and hydroxylamine prevented the development of tolerance to morphine, whereas they had no effect on morphine dependence." | 4.02 | The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice. ( Cetin, Z; Dokmeci, D; Gunduz, O; Karadag, HC; Topuz, RD; Ulugol, A, 2021) |
| "This study evaluates the effect of the slow releasing hydrogen sulfide donor GYY4137 (GYY) on neointimal formation in vivo." | 3.96 | The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in mice. ( Grambow, E; Klar, E; Klee, G; Vollmar, B, 2020) |
| "Atorvastatin significantly ameliorated renal dysfunction and morphological changes in CIAKI rats, as well as inflammation, apoptosis, and excessive oxidative stress." | 3.96 | Atorvastatin protects against contrast-induced acute kidney injury via upregulation of endogenous hydrogen sulfide. ( Jiaqiong, L; Ming, L; Xiaoyong, L; Xinxue, L; Xuexian, T; Yan, L; Yinglan, L; Yue, G; Zena, H, 2020) |
| "Halitosis is highly prevalent in periodontitis and attributed mainly to the presence of volatile sulfur compounds (VSC), where hydrogen sulfide (H2S) is the chief culprit in the characteristic malodor of periodontitis and thus may play an active role in its pathogenesis." | 3.91 | H ( Demasi, AP; Ferreira, HH; Guimarães, RA; Napimoga, MH; Niederauer, AJ; Oliveira, KL; Peruzzo, DC; Pires, AR; Sperandio, M, 2019) |
| "Hydrogen sulfide donors can block the cardiovascular injury of hyperhomocysteinemia." | 3.91 | Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S-sulfhydration in ApoE-knockout atherosclerotic mice. ( Cai, J; Cui, C; Cui, Q; Fan, J; Geng, B; Jiang, S; Li, S; Tang, X; Xu, G; Yang, J; Zhang, J; Zheng, F, 2019) |
| "Studies have shown that hydrogen sulfide (H2S) exerts a neuroprotective effect and may have a therapeutic value for treating neurodegenerative diseases including Parkinson's disease." | 3.88 | Involvement of adenosine triphosphate-sensitive potassium channels in the neuroprotective activity of hydrogen sulfide in the 6-hydroxydopamine-induced animal model of Parkinson's disease. ( Babayan-Tazehkand, A; Haghdoost-Yazdi, H; Rastgoo, N; Sarbazi-Golezari, A; Sarookhani, MR, 2018) |
| "S-sulfhydration is a signalling pathway of hydrogen sulfide (H2S), which is suggested as an anti-atherogenic molecule that may protect against atherosclerosis." | 3.88 | Hydrogen sulfide mediates athero-protection against oxidative stress via S-sulfhydration. ( Cheung, SH; Lau, JYW, 2018) |
| "Previous studies have suggested that exogenous hydrogen sulfide can alleviate the development of diabetic cardiomyopathy (DCM) by inhibiting oxidative stress, inflammation, and apoptosis." | 3.88 | Exogenous hydrogen sulfide attenuates the development of diabetic cardiomyopathy via the FoxO1 pathway. ( Chao, YL; Chen, SL; Gu, Y; Kong, XQ; Luo, J; Ren, XM; Ye, P; Zhang, DM; Zhu, YR; Zuo, GF, 2018) |
| "45) required to produce apnea." | 3.85 | Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model. ( Bebarta, VS; Boss, GR; Boudreau, S; Brenner, M; Castaneda, M; Garrett, N; Maddry, JK; Mahon, SB, 2017) |
| "This study aims to explore the effects of the exogenous hydrogen sulfide (H2S)-mediated scavenger receptor A (SR-A) signaling pathway on renal ischemia/reperfusion injury (IRI) by regulating endoplasmic reticulum (ER) stress-induced autophagy in rats." | 3.85 | Roles of the Exogenous H2S-Mediated SR-A Signaling Pathway in Renal Ischemia/ Reperfusion Injury in Regulating Endoplasmic Reticulum Stress-Induced Autophagy in a Rat Model. ( Ling, Q; Liu, JH; Wang, SG; Wang, T; Ye, ZQ; Yu, X, 2017) |
| "Emerging evidence has suggested that hydrogen sulfide (H2S) may alleviate the cellular damage associated with cerebral ischemia/reperfusion (I/R) injury." | 3.85 | The administration of hydrogen sulphide prior to ischemic reperfusion has neuroprotective effects in an acute stroke model. ( Choi, CG; Choi, Y; Ha, HK; Ham, SJ; Jeon, SB; Jung, SC; Kim, J; Kim, JK; Kim, KW; Kim, ST; Kwon, JI; Shim, WH; Sung, YS; Woo, CW; Woo, DC, 2017) |
| "Allergic asthma was induced with ovalbumin in wild-type (WT) and CSE knock-out (KO) mice at young and old ages." | 3.85 | Age-Dependent Allergic Asthma Development and Cystathionine Gamma-Lyase Deficiency. ( Fu, M; Ju, Y; Qian, Z; Shuang, T; Wang, P; Wang, R; Wu, L, 2017) |
| "In this study, the vitamin D3 plus nicotine (VDN) model of rats was used to prove that H2S alleviates vascular calcification (VC) and phenotype transformation of vascular smooth muscle cells (VSMC)." | 3.83 | Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress. ( Guo, Q; Li, H; Teng, X; Wu, YM; Xiao, L; Xue, HM; Yang, R, 2016) |
| "Hydrogen sulfide (H2S) is an attractive agent for myocardial ischemia-reperfusion injury, however, systemic delivery of H2S may cause unwanted side effects." | 3.83 | Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury. ( Bin, J; Cao, S; Chen, G; Cui, K; Huang, Q; Kutty, S; Liao, W; Liao, Y; Wang, Y; Wu, J; Xiu, J; Yang, L; Zhang, W; Zhong, L, 2016) |
| "The effects of hydrogen sulfide (H2S) on blood-brain barrier (BBB) and brain edema after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) remain poorly understood." | 3.81 | Hydrogen sulfide inhalation decreases early blood-brain barrier permeability and brain edema induced by cardiac arrest and resuscitation. ( Cheng, L; Geng, Y; Li, E; Li, H; Mu, Q; Wei, X; Zhang, B; Zhang, Y, 2015) |
| "During a course of colitis, production of the gaseous mediator hydrogen sulfide (H2S) is markedly up-regulated at sites of mucosal damage and contributes significantly to healing and resolution of inflammation." | 3.81 | Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α. ( Agbor, TA; Buret, AG; Ferraz, JG; Flannigan, KL; Motta, JP; Wallace, JL; Wang, R, 2015) |
| "The discovery of carbon monoxide (CO) and hydrogen sulfide (H2S) as pathogenic signaling molecules in airway-related diseases has led to significant insights into the pathophysiologic mechanisms underlying the development of allergic rhinitis (AR)." | 3.81 | Impact of carbon monoxide/heme oxygenase on hydrogen sulfide/cystathionine-γ-lyase pathway in the pathogenesis of allergic rhinitis in guinea pigs. ( Che, N; Ge, R; Yan, Z; Yu, S; Zhang, X, 2015) |
| " We have previously reported that exposing rats to intermittent hypoxia (IH) to simulate sleep apnea augments myogenic tone in mesenteric arteries through loss of hydrogen sulfide (H2S)-induced dilation." | 3.81 | Intermittent hypoxia in rats reduces activation of Ca2+ sparks in mesenteric arteries. ( Gonzalez Bosc, LV; Jackson-Weaver, O; Kanagy, NL; Naik, JS; Osmond, JM; Walker, BR, 2015) |
| "Hydrogen sulfide (H2S) plays multiple roles in the function of the central nervous system in physiological and pathological conditions, such as cerebral ischemia." | 3.81 | Effect of the Inhibition of Hydrogen Sulfide Synthesis on Ischemic Injury and Oxidative Stress Biomarkers in a Transient Model of Focal Cerebral Ischemia in Rats. ( Bandegi, AR; Hadadha, M; Vakili, A, 2015) |
| "This study is to determine the therapeutic effects of Panax notoginseng saponins (PNSs) on coxsackievirus B3 (CVB3)-induced myocarditis, and whether cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S) pathway is involved." | 3.81 | Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway. ( Chu, M; Geng, Z; Jia, L; Lu, J; Pan, L; Rong, X; Wang, Z; Wu, R; Zhang, C; Zhang, Y; Zhao, Q, 2015) |
| "Acute lung injury (ALI) is one of the fatal outcomes after exposure to high levels of hydrogen sulfide (H2S), and the matrix metalloproteinases (MMPs) especially MMP-2 and MMP-9 are believed to be involved in the development of ALI by degrading the extracellular matrix (ECM) of blood-air barrier." | 3.80 | Dexamethasone ameliorates H₂S-induced acute lung injury by alleviating matrix metalloproteinase-2 and -9 expression. ( Chen, J; Su, C; Wang, J; Xiao, H; Zhang, H; Zhang, J; Zhu, B, 2014) |
| "The aim of the study was to evaluate the clinical efficacy of hydrogen sulfide (H2S) treatment on the endothelin-induced cardiac hypertrophy." | 3.80 | Hydrogen sulfide endothelin-induced myocardial hypertrophy in rats and the mechanism involved. ( Li, Z; Liu, Z; Wang, Q; Wang, Y; Yang, F; Yu, H, 2014) |
| "Acute pulmonary edema (APE) is one of the fatal outcomes after exposure to high levels of hydrogen sulfide (H2S), available evidence suggest that dexamethasone (DXM), a potent anti-inflammatory agent, has been widely used or proposed as a therapeutic approach for H2S-induced APE in clinical practice, however, the underlying mechanism remains poorly understood." | 3.80 | α-ENaC, a therapeutic target of dexamethasone on hydrogen sulfide induced acute pulmonary edema. ( Chen, J; Jiang, L; Qian, W; Su, C; Wang, J; Xiao, H; Zhang, H; Zhang, J; Zhu, B, 2014) |
| "To assess the protective effect of exogenous hydrogen sulfide (H₂S) against myocardial injury after skeletal muscle ischemia/reperfusion (IR) in rats and explore the mechanism." | 3.79 | [Exogenous hydrogen sulfide protects against myocardial injury after skeletal muscle ischemia/reperfusion by inhibiting inflammatory cytokines and oxidative stress in rats]. ( Chen, W; Deng, Z; Li, X; Liu, N; Qi, Y; Xie, X; Yang, J; Zhang, Y, 2013) |
| " The goal of the present study was to determine the therapeutic potential of a stable, long-acting H2S donor, diallyl trisulfide, in a model of pressure-overload heart failure and to assess the effects of chronic H2S therapy on myocardial vascular density and angiogenesis." | 3.79 | Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis. ( Bhushan, S; Bir, SC; Calvert, JW; Kevil, CG; Kondo, K; Lefer, DJ; Murohara, T; Polhemus, D, 2013) |
| "The aim of this study was to determine whether thioredoxin 1 (Trx1) mediates the cardioprotective effects of hydrogen sulfide (H2S) in a model of ischemic-induced heart failure (HF)." | 3.79 | Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. ( Calvert, JW; Lambert, JP; Molkentin, JD; Nicholson, CK; Sadoshima, J, 2013) |
| "The role of hydrogen sulfide (H2 S) in inflammation remains unclear with both pro- and anti-inflammatory actions of this gas described." | 3.79 | The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. ( Fox, B; Keeble, J; Li, L; Moore, PK; Salto-Tellez, M; Whiteman, M; Winyard, PG; Wood, ME, 2013) |
| "Hydrogen sulfide (H(2) S), generated by enzymes such as cystathionine-γ-lyase (CSE) from L-cysteine, facilitates pain signals by activating the Ca(v) 3." | 3.78 | Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice. ( Hayashi, Y; Kawabata, A; Kubo, L; Matsunami, M; Miki, T; Nishikawa, H; Nishiura, K; Okawa, Y; Ozaki, T; Sekiguchi, F; Tsujiuchi, T, 2012) |
| "Hydrogen sulfide (H(2)S) is a novel gaseous mediator that plays important roles in atherosclerosis." | 3.78 | Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice. ( Fan, Y; Gu, T; Guo, C; Sparatore, A; Wang, C; Wu, D; Zhang, A; Zhang, H, 2012) |
| "To investigate the interaction between hydrogen sulfide (H2S)/cystathionine gamma-lyase (CSE) system and nitric oxide (NO)/nitric oxide synthase (NOS) system on cardiac protection in metabolic syndrome (MS) rats." | 3.77 | Interaction between hydrogen sulfide and nitric oxide on cardiac protection in rats with metabolic syndrome. ( Gang, H; Ling-qiao, L; Rong-na, L; Xiang-jun, Z; Yu-han, C, 2011) |
| " Although in chronic heart failure (CHF) there is robust increase in ROS, RNS, and MMP activation, recent data suggest that hydrogen sulfide (H(2)S, a strong antioxidant gas) is cardioprotective." | 3.76 | H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure. ( Givvimani, S; Mishra, PK; Sen, U; Tyagi, N; Tyagi, SC, 2010) |
| "In vitro (enterocyte anoxia-normoxia) and in vivo (rat intestinal ischemia-reperfusion) models of ischemia-reperfusion injury were tested with or without the addition of hydrogen sulfide." | 3.76 | Hydrogen sulfide attenuates ischemia-reperfusion injury in in vitro and in vivo models of intestine free tissue transfer. ( Henderson, PW; Nagineni, V; Singh, SP; Spector, JA; Sung, J; Weinstein, AL, 2010) |
| " Hydrogen sulfide can induce hypothermia and suspended animation-like states in mice." | 3.76 | Inhaled hydrogen sulfide protects against ventilator-induced lung injury. ( Choi, AM; Faller, S; Hoetzel, A; Loop, T; Ryter, SW; Schmidt, R, 2010) |
| "To investigate whether pharmacologic post-conditioning of intestinal tissue with hydrogen sulfide (HS) protects against ischemia reperfusion injury (IRI)." | 3.76 | Hydrogen sulfide attenuates intestinal ischemia-reperfusion injury when delivered in the post-ischemic period. ( Henderson, PW; Jimenez, N; Krijgh, DD; Sohn, AM; Spector, JA; Weinstein, AL, 2010) |
| "To study the protective function and pathophysiology of cystathionine gamma-lyase (CSE)/hydrogen sulfide (H(2)S) system in hepatic ischemia-reperfusion injury (HIRI) in rats." | 3.76 | [Protection of CSE/H2S system in hepatic ischemia reperfusion injury in rats]. ( Jiang, HC; Kang, K; Pan, SH; Sun, XY; Zhao, MY, 2010) |
| "Endogenous hydrogen sulfide (H(2)S) is hypothesized to have an important role in systemic inflammation." | 3.75 | Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma. ( Chen, YH; Geng, B; Qi, YF; Tang, CS; Wang, PP; Wu, R; Yao, WZ, 2009) |
| "To explore the role of hydrogen sulfide/cystathionine-gamma-lyase (H(2)S/CSE) system in lipopolysaccharide (LPS)- induced acute lung injury (ALI) in rats and the underlying mechanisms." | 3.75 | [Role of hydrogen sulfide/cystathionine-gamma-lyase system in acute lung injury induced by lipopolysaccharide in rats]. ( Huang, XL; Ling, YL; Tian, FJ; Wei, P; Zhou, XH, 2009) |
| "Elevated level of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), is associated with end-stage renal diseases." | 3.75 | Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure. ( Abe, OA; Basu, P; Givvimani, S; Metreveli, N; Passmore, JC; Sen, U; Shah, KS; Tyagi, N; Tyagi, SC, 2009) |
| "In this study, we determined the cardioprotective effects of S-propargyl-cysteine (SPRC), a structural analog of S-allylcysteine (SAC), using in vivo models of acute myocardial infarction (MI) and in vitro hypoxic cardiomyocytes models." | 3.75 | S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway. ( Liu, HR; Mu, Q; Rose, P; Wang, Q; Zhu, YZ, 2009) |
| "The animal model of acute lung injury (ALI) caused by intravenous injection of lipopolysaccharides (LPS) and cultured human peripheral blood polymorphonuclear neutrophil (PMN) were used to study the effects of sodium hydrosulfide (NaHS), hydrogen sulfide (H2S) donor, on LPS-induced PMN accumulation, microvascular permeability and PMN apoptosis." | 3.75 | [Role of polymorphonuclear neutrophil in exogenous hydrogen sulfide attenuating endotoxin-induced acute lung injury]. ( Ding, CH; Huang, XL; Xian, XH; Zhou, JL; Zhou, XH, 2009) |
| "The role of hydrogen sulfide (H(2)S) in myocardial infarction (MI) has not been previously studied." | 3.74 | Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats. ( Ho, P; Huang, SH; Loke, YY; Lu, J; Moore, PK; Tan, CS; Wang, ZJ; Whiteman, M; Zhu, YC; Zhu, YZ, 2007) |
| "Mesalamine is the first-line therapy for colitis, but it lacks potency and is only effective for mild-to-moderate forms of this disease." | 3.74 | Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. ( Caliendo, G; Cirino, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Orlandi, S; Santagada, V; Santucci, L; Wallace, JL, 2007) |
| "To study the changes of endogenous hydrogen sulfide (H(2)S) and the effect of exogenously applied H(2)S on ovalbumin-induced acute asthma." | 3.74 | [The regulatory effect of endogenous hydrogen sulfide on acute asthma]. ( Chen, YH; Geng, B; Lu, M; Tang, CS; Wu, R; Yao, WZ, 2007) |
| "Cysteine is known to cause neuronal cell death and has been reported to be elevated in brain ischemia, but it has not been studied in clinical stroke." | 3.73 | High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide. ( Chang, HM; Chen, CP; Chimon, GN; Halliwell, B; Ng, YK; Qu, K; Rumpel, H; Seah, AB; Wong, MC; Wong, PT, 2006) |
| "To explore the impact of hydrogen sulfide (H2S) donor, sodium hydrosulfide (NaHS), on pulmonary vascular structure and vasoactive peptides in rats with pulmonary hypertension induced by high pulmonary blood flow." | 3.73 | [Impact of hydrogen sulfide donor on pulmonary vascular structure and vasoactive peptides in rats with pulmonary hypertension induced by high pulmonary blood flow]. ( Du, JB; Li, XH; Tang, CS, 2006) |
| "Mycophenolic acid was detected in all cats." | 2.61 | ( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019) |
| "Hydrogen sulfide (H2S) is an endogenous gas with important physiologic functions in the brain, vasculature and other organs." | 2.55 | Hydrogen Sulfide and Inflammatory Joint Diseases. ( Blanco, FJ; Burguera, EF; Meijide-Failde, R, 2017) |
| "Obesity is associated with elevated plasma cysteine, whereas diabetes is associated with reduced cysteine levels." | 2.53 | Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology. ( Carter, RN; Morton, NM, 2016) |
| "Animal models of CBS deficiency have provided invaluable insights into the pathological effects of transsulfuration impairment and of both mild and severe HHcy." | 2.47 | Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research. ( Beard, RS; Bearden, SE, 2011) |
| "Physiopathological mechanisms and treatment of pain remain a significant challenge." | 2.47 | Hydrogen sulphide and pain. ( Distrutti, E, 2011) |
| "H2S (hydrogen sulfide) is a well known and pungent gas recently discovered to be synthesized enzymatically in mammalian and human tissues." | 2.47 | Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. ( Chopra, M; Fox, B; Le Trionnaire, S; Whatmore, J; Whiteman, M, 2011) |
| "Hypertension is a major risk factor for intimal hyperplasia (IH) and re-stenosis following vascular and endovascular interventions." | 1.72 | Hydrogen Sulphide Release via the Angiotensin Converting Enzyme Inhibitor Zofenopril Prevents Intimal Hyperplasia in Human Vein Segments and in a Mouse Model of Carotid Artery Stenosis. ( Allagnat, F; Corpataux, JM; Déglise, S; Deslarzes-Dubuis, C; Lambelet, M; Longchamp, A; Macabrey, D; Ozaki, CK, 2022) |
| "Sepsis often leads to multiple organ failure or even death and is a significant health problem that contributes to a heavy economic burden." | 1.72 | Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury. ( Li, J; Li, L; Li, M; Ma, J; Yao, C; Yao, S, 2022) |
| "Glaucoma is a neurodegenerative disease of visual system characterized by gradual loss of retinal ganglion cells (RGC)." | 1.72 | Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model. ( Chen, J; Huang, P; Huang, S; Liu, X; Shen, X; Wang, J; Yu, H; Zhong, Y, 2022) |
| "Therapies to treat chronic neuropathic pain and its associated comorbidities are limited." | 1.56 | Treatment with slow-releasing hydrogen sulfide donors inhibits the nociceptive and depressive-like behaviours accompanying chronic neuropathic pain: Endogenous antioxidant system activation. ( Batallé, G; Cabarga, L; Pol, O, 2020) |
| "Hydrogen sulfide (H2S) has drawn considerable attention in recent years for its potential as a cardiovascular protector." | 1.56 | Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway. ( Ling, X; Sun, J; Wang, P; Xi, W; Xiao, J; Xue, X; Yang, Q, 2020) |
| "Prenatal treatment of Down syndrome fetuses is also suggested." | 1.51 | Mental retardation in Down syndrome: Two ways to treat. ( Kamoun, PP, 2019) |
| "Trimetazidine is a piperazine-derived metabolic agent." | 1.51 | The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress. ( Liu, C; Zheng, W, 2019) |
| "Backgroud: Alzheimer disease is an age-related severe neurodegenerative pathology." | 1.51 | Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer's Disease in Transgenic Mice at Different Ages. ( Calevro, A; Canalini, F; Cavallini, GM; Giuliani, D; Guarini, S; Ottani, A; Rossi, R; Vandini, E; Zaffe, D, 2019) |
| "Hydrogen sulfide (H2S) is a novel gasotransmitter that regulates vascular homeostasis." | 1.51 | Hydrogen sulfide improves vascular repair by promoting endothelial nitric oxide synthase-dependent mobilization of endothelial progenitor cells. ( Chen, Y; Deng, B; Hu, Q; Huang, Q; Ke, X; Nie, R; Wang, J; Xie, S; Zhang, T, 2019) |
| "Hydrogen sulfide (H2S) is an important signaling molecule with promising protective effects in many physiological and pathological processes." | 1.51 | Controllable thioester-based hydrogen sulfide slow-releasing donors as cardioprotective agents. ( Liu, J; Liu, Y; Luo, S; Xie, S; Xu, J; Xu, S; Yao, H; Zhu, Z, 2019) |
| "Hemorrhagic shock was induced by bleeding the animals." | 1.48 | Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks. ( Coskun, CN; Demirel-Yilmaz, E; Savci, V; Usanmaz, SE, 2018) |
| "Glaucoma is a group of neurodegenerative eye diseases characterized by progressive impairment of visual function due to loss of retinal ganglion cells (RGC)." | 1.48 | Hydrogen sulfide supplement attenuates the apoptosis of retinal ganglion cells in experimental glaucoma. ( Guo, L; Huang, P; Huang, S; Li, C; Lin, Z; Liu, X; Shen, X; Xu, X; Zhong, Y, 2018) |
| "Bladder pain is a prominent symptom of interstitial cystitis/painful bladder syndrome." | 1.48 | Endogenous H ( Bo, Q; Cui, J; Du, J; Shi, B; Wang, W; Wang, Y; Yu, X; Zhao, H; Zhu, K; Zhu, Y, 2018) |
| "Hydrogen sulfide has been recognized as an important neuroprotective agent in the nervous system." | 1.48 | Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat. ( Jiang, A; Liu, Y; Pan, L; Yin, M, 2018) |
| "Hydrogen sulfide (H2S) is a gaseous mediator recognized as important neuromodulator agent in the central nervous system." | 1.48 | Novel neuroprotective role of hydrogen sulfide in a rat model of stress brain injury. ( Elbassuoni, EA; Nazmy, WH, 2018) |
| "Hydrogen sulfide (H2S) is an essential neuromodulator, generates by cystathionine β synthase (CBS) or 3-mecaptopyruvate sulfurtransferase (3MST) in the brain." | 1.48 | Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis. ( Cai, J; Cui, C; Cui, Q; Geng, B; Han, J; Lu, H; Tang, C; Xu, G; Yang, J; Zheng, F; Zhou, Y, 2018) |
| "Cardiac hypertrophy is a critical component of phenotype in the failing heart." | 1.46 | Protective effect of hydrogen sulphide against myocardial hypertrophy in mice. ( Chen, G; Hu, L; Jiang, R; Lin, C; Ping, J; Shan, J; Shao, M; Tian, H; Wang, L; Zhuo, C, 2017) |
| "Hydrogen sulfide (H2S) is a crucial signaling molecule with a wide range of physiological functions." | 1.46 | Hydrogen Sulfide Inhibits Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior by Upregulation of Sirt-1: Involvement in Suppression of Hippocampal Endoplasmic Reticulum Stress. ( Gu, HF; Kan, LY; Li, D; Liu, SY; Tang, XQ; Zeng, HY; Zhang, P; Zou, W, 2017) |
| "Hydrogen sulfide (H2S) has anti‑inflammatory and neuroprotective properties, particularly during pathological processes." | 1.46 | Hydrogen sulfide protects against the development of experimental cerebral malaria in a C57BL/6 mouse model. ( Han, Z; Huang, J; Jiang, P; Lun, Z; Xiao, B; Xu, J; Xu, Z; Zhou, W, 2017) |
| "Autophagy is upregulated in spinal cord ischemia reperfusion (SCIR) injury; however, its expression mechanism is largely unknown; moreover, whether autophagy plays a neuroprotective or neurodegenerative role in SCIR injury remains controversial." | 1.46 | Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury. ( Li, C; Liang, Y; Xie, L; Yang, K; Yu, S, 2017) |
| "Glaucoma is an irreversible and blinding neurodegenerative disease of the eye, and is characterized by progressive loss of retinal ganglion cells (RGCs)." | 1.46 | Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model. ( Guo, L; Huang, P; Huang, S; Leung, CK; Lin, Z; Liu, X; Wang, J; Xu, S; Zhong, Y, 2017) |
| "During resuscitated septic shock in swine with CAD, GYY4137 shifted metabolism to preferential carbohydrate utilization." | 1.46 | Metabolic, Cardiac, and Renal Effects of the Slow Hydrogen Sulfide-Releasing Molecule GYY4137 During Resuscitated Septic Shock in Swine with Pre-Existing Coronary Artery Disease. ( Calzia, E; Georgieff, M; Gröger, M; Hafner, S; Matallo, J; McCook, O; Nußbaum, BL; Radermacher, P; Vogt, J; Wachter, U; Wepler, M; Whiteman, M; Wood, ME, 2017) |
| "Hydrogen sulfide (H2S) plays an essential role in bone formation, in part, by inhibiting osteoclast differentiation, maintaining mesenchymal stem cell osteogenesis ability, or reducing osteoblast injury." | 1.46 | Cystathionine γ-Lyase-Hydrogen Sulfide Induces Runt-Related Transcription Factor 2 Sulfhydration, Thereby Increasing Osteoblast Activity to Promote Bone Fracture Healing. ( Cai, J; Cui, Q; Fan, J; Geng, B; Liao, F; Lin, X; Yang, J; Zheng, F; Zheng, Y, 2017) |
| "Hydrogen sulfide (H₂S) is an endogenous mediator, synthesized from l-cysteine by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) or 3-mercaptopyruvate sulfurtransferase (3-MST)." | 1.46 | Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations. ( Brzozowski, T; Ginter, G; Hubalewska-Mazgaj, M; Kwiecien, S; Magierowska, K; Magierowski, M; Pajdo, R; Sliwowski, Z, 2017) |
| "We investigated whether mild hypothermia combined with sodium hydrosulfide treatment during resuscitation improves neuron survival following cerebral ischemia-reperfusion injury beyond that observed for the individual treatments." | 1.43 | Mild Hypothermia Combined with Hydrogen Sulfide Treatment During Resuscitation Reduces Hippocampal Neuron Apoptosis Via NR2A, NR2B, and PI3K-Akt Signaling in a Rat Model of Cerebral Ischemia-Reperfusion Injury. ( Dai, HB; Duan, ML; Ji, XJ; Lv, J; Ma, RM; Miao, XL; Xu, MM; Zhu, SH, 2016) |
| "Obesity was found to be associated with decreased vessel H2S concentration, inward hypertrophic remodeling, altered collagen-to-elastin ratio, and reduced vessel stiffness." | 1.43 | Hydrogen sulfide depletion contributes to microvascular remodeling in obesity. ( Candela, J; Velmurugan, GV; White, C, 2016) |
| " Endothelial function and NO bioavailability were significantly reduced in the WD group (p < 0." | 1.43 | Decreased vascular H2S production is associated with vascular oxidative stress in rats fed a high-fat western diet. ( Hart, JL; Jenkins, TA; Nguyen, JC, 2016) |
| "Hydrogen sulfide (H2S) is a critical signaling molecule that regulates many physiological and/or pathological processes." | 1.43 | pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury. ( Kang, J; Lefer, DJ; Li, Z; Organ, CL; Pacheco, A; Park, CM; Wang, D; Xian, M; Yang, CT, 2016) |
| "Hydrogen sulfide (H2S) has been found to be the third gaseous signaling molecule with anti‑ER stress effects." | 1.43 | Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model. ( Li, F; Li, L; Li, Y; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2016) |
| "Current COPD therapy involving anticholinergics, β2-adrenoceptor agonists and/or corticosteroids, do not specifically target oxidative stress, nor do they reduce chronic pulmonary inflammation and disease progression in all patients." | 1.43 | The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease. ( Bos, IS; Graaf, AC; Halayko, AJ; Han, B; Henning, RH; Krenning, G; Maarsingh, H; Meurs, H; Poppinga, WJ; Schmidt, M; Smit, M; Stienstra, S; van Vliet, B; Vogelaar, P; Zuidhof, AB; Zuo, H, 2016) |
| "Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule with significant pathophysiological importance, but its role in retinal neovascular diseases is unknown." | 1.43 | Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy. ( Coletta, C; Gersztenkorn, D; Ha, Y; Liu, H; Motamedi, M; Szabo, C; Tie, H; Zhang, W; Zhou, J; Zhu, S, 2016) |
| "Hydrogen sulfide (H2S) has been shown to exert cardioprotective effects in MI." | 1.43 | Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages. ( Miao, L; Moore, PK; Shen, X; Shen, Y; Whiteman, M; Xin, H; Xin, X; Zhu, YZ, 2016) |
| "Patients with sleep apnea and rodents exposed to intermittent hypoxia exhibit hypertension." | 1.43 | H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. ( Khan, SA; Kumar, GK; Nanduri, J; Peng, YJ; Prabhakar, NR; Semenza, GL; Singh, A; Snyder, SH; Vasavda, C; Yuan, G, 2016) |
| " Here, we report that chronic administration of sodium hydrosulfide (NaHS, a H2S donor) elevated hippocampal H2S levels and enhanced hippocampus-dependent contextual fear memory and novel object recognition in amyloid precursor protein (APP)/presenilin-1 (PS1) transgenic mice." | 1.43 | GluN2B-containing NMDA receptors contribute to the beneficial effects of hydrogen sulfide on cognitive and synaptic plasticity deficits in APP/PS1 transgenic mice. ( Tang, ZY; Wang, T; Wang, W; Wei, B; Xu, GG; Yang, YJ; Yu, B; Zhan, JQ; Zhao, Y, 2016) |
| "Hydrogen sulfide (H2S) has been proposed to exert pro- as well as anti-inflammatory effects in various models of critical illness." | 1.43 | Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase. ( Ahmad, A; Gerö, D; Olah, G; Szabo, C, 2016) |
| "Hydrogen sulfide (H2S) is an endogenously produced gasotransmitter with cardioprotective properties." | 1.42 | Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats. ( de Boer, RA; Frenay, AR; Hillebrands, JL; Leuvenink, HG; Pasch, A; Snijder, PM; van Goor, H, 2015) |
| " Both aortic endothelial function and NO bioavailability were significantly attenuated in the AngII group (P < 0." | 1.42 | Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice. ( Al-Magableh, MR; Hart, JL; Kemp-Harper, BK, 2015) |
| "In the mice with cerulein-induced acute pancreatitis, the referred hyperalgesia was suppressed by NNC 55-0396 (NNC), a selective T-channel inhibitor; zinc chloride; or ascorbic acid, known to inhibit Ca(v)3." | 1.42 | Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis. ( Fujimura, M; Kawabata, A; Nishimura, S; Sekiguchi, F; Terada, Y; Tsubota, M, 2015) |
| "Hydrogen sulfide is a mediator of IRI and can ameliorate tissue injury in many organ systems." | 1.42 | Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats. ( Furness, P; Hosgood, SA; Hunter, JP; Nicholson, ML; Patel, M; Sayers, RD, 2015) |
| "Three animals (18%) presented a cardiac arrest within 90 s and were unable to receive any antidote or vehicle." | 1.42 | High-dose hydroxocobalamin administered after H2S exposure counteracts sulfide-poisoning-induced cardiac depression in sheep. ( Chenuel, B; Haouzi, P; Sonobe, T, 2015) |
| "Treatment with naproxen increased the thickness of the corneal and epithelial layers of the oesophagus, as well as producing disorganization of the muscle plate and irregular submucosal oedema." | 1.42 | Exposure to non-steroid anti-inflammatory drugs (NSAIDs) and suppressing hydrogen sulfide synthesis leads to altered structure and impaired function of the oesophagus and oesophagogastric junction. ( Bula, N; Gavrilyuk, E; Khyrivska, D; Wallace, JL; Zayachkivska, O, 2015) |
| "Hydrogen sulfide (H2S) was first proposed to be a neuromodulator in 1996." | 1.42 | Neuroprotective effects of hydrogen sulfide in Parkinson's disease animal models: methods and protocols. ( Bian, JS; Xue, X, 2015) |
| "Seventy-five percent of the comatose rats that received saline (n = 8) died within 7 min, while all the 7 rats that were given MB survived (p = 0." | 1.42 | H2S induced coma and cardiogenic shock in the rat: Effects of phenothiazinium chromophores. ( Haouzi, P; Sonobe, T, 2015) |
| "Rats underwent 2-h middle cerebral artery occlusion (MCAO) and received 40 ppm or 80 ppm H2S inhalation for 3h at the beginning of reperfusion." | 1.42 | Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC. ( Cheng, L; Chi, M; Deng, L; Pan, H; Wang, G; Wei, X; Yao, X; Zhang, B, 2015) |
| "Hydrogen sulfide (H2S) is a vasoactive gasotransmitter that is endogenously produced in the vasculature by the enzyme cystathionine γ-lyase (CSE)." | 1.42 | Cystathionine γ-lyase regulates arteriogenesis through NO-dependent monocyte recruitment. ( Bir, SC; Kevil, CG; Kolluru, GK; Pardue, S; Shen, X; Wang, R; Yuan, S, 2015) |
| "Ischemia-reperfusion injury is unavoidable during organ transplantation." | 1.42 | Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation. ( Carter, D; Davison, M; Gunaratnam, L; Haig, A; Liu, W; Lobb, I; Sener, A, 2015) |
| "Hydrogen sulfide (H2S) has been reported to be interwined in multiple systems, specifically in the cardiovascular system." | 1.42 | An exogenous hydrogen sulphide donor, NaHS, inhibits the apoptosis signaling pathway to exert cardio-protective effects in a rat hemorrhagic shock model. ( Dai, X; Gao, C; Wu, C; Xu, X; Xu, Y; Zhu, D, 2015) |
| "Transient cerebral ischemia was induced using the Pulsinelli four-vessel occlusion method." | 1.42 | Hydrogen sulphide and mild hypothermia activate the CREB signaling pathway and prevent ischemia-reperfusion injury. ( Dai, HB; Duan, ML; Hu, YM; Ji, X; Li, WY; Ma, RM; Miao, XL; Zhang, LD; Zhu, SH, 2015) |
| "Hydrogen sulfide has recently been found decreased in chronic kidney disease." | 1.40 | Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy. ( Hu, LF; Li, Q; Liu, CF; Peng, H; Shen, HY; Shi, YB; Song, K; Wang, F; Zheng, HF, 2014) |
| "Hydrogen sulfide (H2 S) is a gas transmitter that may mediate cerebral ischemic injury." | 1.40 | Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability. ( Chen, JG; Guan, XL; He, JG; Hu, ZL; Luo, Y; Wang, F; Wu, PF; Xiao, W; Zhang, JT; Zhou, J, 2014) |
| "Hydrogen sulfide (H2S) has been reported to have proangiogenic effects." | 1.40 | Hydrogen sulfide improves wound healing via restoration of endothelial progenitor cell functions and activation of angiopoietin-1 in type 2 diabetes. ( Chen, AF; Chen, DD; Jia, W; Jia, WP; Liu, F; Sun, X; Xie, HH; Yuan, H, 2014) |
| "Hydrogen sulfide (H2S) is a toxic gas now being recognized as an endogenous signaling molecule in multiple organ systems, in particular, the cardiovascular system." | 1.40 | Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis. ( Dong, M; Hu, N; Ren, J, 2014) |
| "Hydrogen sulfide (H2S) is a highly toxic gas for which no effective antidotes exist." | 1.40 | The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model. ( Alexander, C; Azer, SM; Benavides, S; Boss, GR; Brenner, M; Chan, A; Jiang, J; Lee, J; Mahon, SB; Mukai, D; Narula, N; Viseroi, M; Yoon, D, 2014) |
| "Hydrogen sulfide (H2 S) is a potent vasodilator and regulates cardiovascular homeostasis." | 1.40 | Hydrogen sulfide treatment induces angiogenesis after cerebral ischemia. ( Choi, IY; Jang, H; Kim, YJ; Lee, SH; Oh, MY; Ryu, WS; Yang, HS; Yoon, BW, 2014) |
| "Hydrogen sulfide (H2S) is an important gaseous signaling agent mediated by many physiological processes and diseases." | 1.40 | Inorganic-organic hybrid nanoprobe for NIR-excited imaging of hydrogen sulfide in cell cultures and inflammation in a mouse model. ( Chen, W; Huang, L; Huang, W; Loo, JS; Pei, W; Wang, C; Yan, Q; Yao, C; Zhang, Q; Zhou, Y; Zhu, J, 2014) |
| "Pretreatment with naproxen in the WRS model caused an increase in severity of damage and a decrease in NOS activity." | 1.40 | Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage. ( Biletska, L; Bondarchuk, T; Fomenko, I; Panasyuk, N; Sklyarov, A; Wallace, JL, 2014) |
| "Hydrogen sulfide has been demonstrated to be a critical mediator of gastric and intestinal mucosal protection and repair." | 1.40 | Cytoprotective effects of hydrogen sulfide in novel rat models of non-erosive esophagitis. ( Bula, N; Grushka, O; Havryluk, O; Hrycevych, N; Wallace, JL; Zayachkivska, O, 2014) |
| "The exact etiology of preeclampsia is unknown, but there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation." | 1.39 | Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia. ( Ahmad, S; Ahmed, A; Baily, J; Buhimschi, CS; Buhimschi, IA; Cai, M; Crispi, F; Cudmore, M; Fujisawa, T; Gratacós, E; Hadoke, PW; Miller, MR; Rennie, J; Wang, K; Wang, R, 2013) |
| "Depression is a common and debilitating mental illness and is often comorbid with anxiety disorders." | 1.39 | Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in behavioral models of depression and anxiety. ( Chen, WL; Hu, B; Niu, YY; Tang, XQ; Tian, Y; Xie, B; Xu, KL; Zhang, C; Zhang, P; Zou, W, 2013) |
| "Hydrogen sulfide (H(2)S) has recently been found to play beneficial roles in ameliorating several diseases, including hypertension, atherosclerosis and cardiac/renal ischemia-reperfusion injuries." | 1.39 | Distribution of hydrogen sulfide (H₂S)-producing enzymes and the roles of the H₂S donor sodium hydrosulfide in diabetic nephropathy. ( Imai, E; Kimura, T; Kojima, H; Kosugi, T; Maruyama, S; Matsuo, S; Niki, I; Sato, W; Taniguchi, S; Yamamoto, J; Yamamoto, T; Yuzawa, Y, 2013) |
| "Hydrogen sulfide (H(2)S) is a gaseous neuromodulator endogenously produced in the brain by the enzyme cystathionine β-synthase (CBS)." | 1.39 | Hydrogen sulfide inhibits preoptic prostaglandin E2 production during endotoxemia. ( Araujo, RM; Azevedo, LU; Batalhao, ME; Branco, LG; Carnio, EC; Coimbra, TM; Francescato, HD; Kwiatkoski, M; Soriano, RN, 2013) |
| "Hydrogen sulfide (H(2)S) is an endogenous signaling gas, which possesses potent anti-oxidant, anti-inflammatory, anti-hypertensive and other regulatory functions." | 1.38 | Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease. ( Aminzadeh, MA; Vaziri, ND, 2012) |
| "Hydrogen sulfide (H(2)S) is a novel agent that has been previously shown to scavenge ROS and slow metabolism." | 1.38 | Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation. ( Arnaoutakis, GJ; Beaty, CA; Berkowitz, DE; George, TJ; Jandu, SK; Santhanam, L; Shah, AS, 2012) |
| "Hydrogen sulfide (H(2)S) has been shown to protect neurons." | 1.37 | Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease. ( Ichinose, F; Kakinohana, M; Kaneki, M; Kida, K; Marutani, E; Tokuda, K; Yamada, M, 2011) |
| "In septic rats pretreated with AOAA, sepsis-associated hippocampus inflammation was reduced." | 1.37 | Effects of hydrogen sulfide on a rat model of sepsis-associated encephalopathy. ( Chen, D; Lan, X; Li, C; Liu, B; Pan, H; Yang, G, 2011) |
| "Hydrogen sulfide (H( 2)S) is a biological mediator produced by enzyme-regulated pathways from L-cysteine, which is a substrate for cystathionine-gamma-lyase (CSE)." | 1.36 | L-cysteine stimulates hydrogen sulfide synthesis in myocardium associated with attenuation of ischemia-reperfusion injury. ( Baxter, GF; Elsey, DJ; Fowkes, RC, 2010) |
| "Hydrogen sulfide (H(2)S) is a gaseous messenger and serves as an important neuromodulator in central nervous system." | 1.36 | Dynamic change of hydrogen sulfide during global cerebral ischemia-reperfusion and its effect in rats. ( Du, A; Li, D; Mayhan, WG; Ren, C; Sui, J; Zhao, H, 2010) |
| "Hydrogen sulfide (H(2)S) is an endogenously produced gaseous signaling molecule with diverse physiological activity." | 1.35 | Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling. ( Calvert, JW; Duranski, MR; Jha, S; Lefer, DJ; Ramachandran, A, 2008) |
| "Hydrogen sulfide was administered to rats either via airway as gas, or intravenous infusion as liquid." | 1.35 | Surviving blood loss using hydrogen sulfide. ( Blackwood, JE; Iwata, A; Lockett, SL; Morrison, ML; Roth, MB; Winn, RK, 2008) |
| "Hydrogen sulfide (H2S) is an endogenously gaseous mediator, regulating many pathophysiological functions in mammalian cells." | 1.35 | Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. ( Bai, XB; Cao, YX; Liu, H; Shi, S, 2009) |
| "Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator of mucosal defense with antiinflammatory effects that promote ulcer healing." | 1.35 | Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. ( Dicay, M; Martin, GR; McKnight, W; Vong, L; Wallace, JL, 2009) |
| "In aged humans, stroke is a major cause of disability for which no neuroprotective measures are available." | 1.35 | Strategies to improve post-stroke behavioral recovery in aged subjects. ( Bălşeanu, A; Buga, AM; Mogoantă, L; Popa-Wagner, A, 2009) |
| "Hydrogen sulfide (H(2)S) is a naturally occurring gas that has been shown to be a potent vasodilator." | 1.35 | Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injury. ( Bhatia, M; Moore, PK; Sidhapuriwala, JN; Sparatore, A, 2008) |
| "Focal cerebral ischemia was produced by reversible occlusion of the right middle cerebral artery in 17-month-old male Sprague-Dawley rats." | 1.35 | Long-term hypothermia reduces infarct volume in aged rats after focal ischemia. ( Balseanu, AT; Buga, AM; Florian, B; Grisk, O; Kessler, C; Popa-Wagner, A; Vintilescu, R; Walker, LC, 2008) |
| "Hydrogen sulfide (H2S) is a naturally occurring gaseous transmitter, which may play important roles in normal physiology and disease." | 1.33 | Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. ( Anuar, FB; Bhatia, M; Collin, M; Moore, PK; Murch, O; Thiemermann, C, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 52 (15.34) | 29.6817 |
| 2010's | 237 (69.91) | 24.3611 |
| 2020's | 50 (14.75) | 2.80 |
| Authors | Studies |
|---|---|
| Ali Qaba, MAM | 1 |
| Saleem, MK | 1 |
| Ali Qaba, NK | 1 |
| Alani, MA | 1 |
| Ahmed, MM | 1 |
| Sabry, SM | 1 |
| Macabrey, D | 1 |
| Deslarzes-Dubuis, C | 1 |
| Longchamp, A | 3 |
| Lambelet, M | 1 |
| Ozaki, CK | 3 |
| Corpataux, JM | 2 |
| Allagnat, F | 1 |
| Déglise, S | 1 |
| Li, J | 7 |
| Li, M | 2 |
| Li, L | 9 |
| Ma, J | 1 |
| Yao, C | 2 |
| Yao, S | 1 |
| Corvino, A | 1 |
| Citi, V | 1 |
| Fiorino, F | 1 |
| Frecentese, F | 1 |
| Magli, E | 1 |
| Perissutti, E | 1 |
| Santagada, V | 2 |
| Calderone, V | 2 |
| Martelli, A | 2 |
| Gorica, E | 1 |
| Brogi, S | 1 |
| Colombo, FF | 1 |
| Capello, CN | 1 |
| Araujo Ferreira, HH | 1 |
| Rimoli, MG | 1 |
| Sodano, F | 1 |
| Rolando, B | 1 |
| Pavese, F | 1 |
| Petti, A | 1 |
| Muscará, MN | 1 |
| Caliendo, G | 2 |
| Severino, B | 1 |
| Nakladal, D | 1 |
| Lambooy, SPH | 1 |
| Mišúth, S | 1 |
| Čepcová, D | 1 |
| Joschko, CP | 1 |
| van Buiten, A | 1 |
| Goris, M | 1 |
| Hoogstra-Berends, F | 1 |
| Kloosterhuis, NJ | 2 |
| Huijkman, N | 1 |
| van de Sluis, B | 1 |
| Diercks, GF | 1 |
| Buikema, JH | 1 |
| Henning, RH | 3 |
| Deelman, LE | 1 |
| Huang, S | 4 |
| Huang, P | 3 |
| Yu, H | 3 |
| Chen, J | 6 |
| Liu, X | 7 |
| Wang, J | 10 |
| Shen, X | 5 |
| Zhong, Y | 3 |
| Shahi, SK | 1 |
| Ghimire, S | 1 |
| Lehman, P | 1 |
| Mangalam, AK | 1 |
| Nagashima, F | 2 |
| Miyazaki, Y | 2 |
| Kanemaru, E | 2 |
| Ezaka, M | 2 |
| Hara, H | 2 |
| Sugiura, K | 2 |
| Boerboom, SL | 2 |
| Ostrom, KF | 2 |
| Jiang, W | 3 |
| Bloch, DB | 2 |
| Ichinose, F | 3 |
| Marutani, E | 3 |
| Wilkie, SE | 1 |
| Marcu, DE | 1 |
| Carter, RN | 2 |
| Morton, NM | 2 |
| Gonzalo, S | 1 |
| Selman, C | 1 |
| Hunter, CE | 1 |
| Mesfin, FM | 1 |
| Manohar, K | 1 |
| Liu, J | 6 |
| Shelley, WC | 2 |
| Brokaw, JP | 1 |
| Pecoraro, AR | 1 |
| Hosfield, BD | 1 |
| Markel, TA | 2 |
| Bobenko, AI | 1 |
| Heller, S | 1 |
| Schmitt, N | 1 |
| Cherdtrakulkiat, R | 1 |
| Lawung, R | 1 |
| Nabu, S | 1 |
| Tantimavanich, S | 1 |
| Sinthupoom, N | 1 |
| Prachayasittikul, S | 1 |
| Prachayasittikul, V | 1 |
| Zhang, B | 3 |
| Wu, C | 2 |
| Zhang, Z | 2 |
| Yan, K | 1 |
| Li, C | 6 |
| Li, Y | 8 |
| Zheng, C | 1 |
| Xiao, Y | 3 |
| He, D | 1 |
| Zhao, F | 1 |
| Su, JF | 1 |
| Lun, SM | 1 |
| Hou, YJ | 1 |
| Duan, LJ | 1 |
| Wang, NC | 1 |
| Shen, FF | 1 |
| Zhang, YW | 1 |
| Gao, ZW | 1 |
| Du, XJ | 1 |
| Zhou, FY | 1 |
| Yin, Z | 1 |
| Zhu, J | 4 |
| Yan, D | 1 |
| Lou, H | 1 |
| Feng, C | 1 |
| Wang, Z | 6 |
| Wang, Y | 12 |
| Hu, X | 2 |
| Li, Z | 7 |
| Shen, Y | 2 |
| Hu, D | 1 |
| Chen, H | 1 |
| Wu, X | 1 |
| Duan, Y | 1 |
| Zhi, D | 1 |
| Zou, M | 2 |
| Zhao, Z | 2 |
| Zhang, X | 3 |
| Yang, X | 5 |
| Zhang, J | 6 |
| Wang, H | 2 |
| Popović, KJ | 1 |
| Popović, DJ | 1 |
| Miljković, D | 1 |
| Lalošević, D | 1 |
| Čapo, I | 1 |
| Popović, JK | 1 |
| Liu, M | 2 |
| Song, H | 2 |
| Xing, Z | 1 |
| Lu, G | 1 |
| Chen, D | 2 |
| Valentini, AM | 1 |
| Di Pinto, F | 1 |
| Coletta, S | 1 |
| Guerra, V | 1 |
| Armentano, R | 1 |
| Caruso, ML | 1 |
| Gong, J | 1 |
| Wang, N | 2 |
| Bian, L | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease[NCT05457881] | 226 participants (Anticipated) | Interventional | 2024-03-01 | Not yet recruiting | |||
| A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock[NCT03783091] | Phase 2 | 20 participants (Anticipated) | Interventional | 2019-08-05 | Recruiting | ||
| Hydrogen Sulfide as Prognostic Factor[NCT01088490] | 50 participants (Actual) | Observational | 2010-01-31 | Completed | |||
| Comparison of the Concentration of Estrogen and Testosterone Ratio in Male Patients With Cirrhosis and Hypotension Compared to Male Cirrhosis Patients Without Hypotension[NCT05051293] | 0 participants (Actual) | Observational | 2021-08-22 | Withdrawn (stopped due to Study will be changed from prospective to retrospective) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
21 reviews available for hydrogen sulfide and Disease Models, Animal
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P | 2019 |
To solve our new emergency care crisis, let's start with the old one.
Topics: Animals; Argon; Carbon Monoxide; Disease Models, Animal; Emergency Medical Services; Helium; Humans; | 2020 |
A New Hope for a Devastating Disease: Hydrogen Sulfide in Parkinson's Disease.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Humans; Hydrogen Sulfide; Neurons; Parkinson Dise | 2018 |
Is hydrogen sulfide a potential novel therapy to prevent renal damage during ureteral obstruction?
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Fibrosis; Gasotransmitters; Humans; Hydrogen Sulfi | 2018 |
Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects.
Topics: Animals; Brain Ischemia; Caloric Restriction; Comorbidity; Diabetes Mellitus; Diet, High-Fat; Diseas | 2017 |
Role of hydrogen sulfide in cerebrovascular alteration during aging.
Topics: Aging; Animals; Apoptosis; Brain; Cellular Senescence; Cerebrovascular Circulation; Cognitive Dysfun | 2019 |
Potential role of hydrogen sulfide in the pathogenesis of vascular dysfunction in septic shock.
Topics: Animals; Disease Models, Animal; Endothelium, Vascular; Humans; Hydrogen Sulfide; Muscle, Smooth, Va | 2013 |
Hydrogen sulfide in cell signaling, signal transduction, cellular bioenergetics and physiology in C. elegans.
Topics: Adenosine Triphosphate; Animals; Caenorhabditis elegans; Cystathionine beta-Synthase; Disease Models | 2013 |
Gaseous therapeutics in acute lung injury.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Carbon Monoxide; Disease Models, Animal; Hum | 2011 |
Advances in the pathophysiology of preeclampsia and related podocyte injury.
Topics: Animals; Disease Models, Animal; Female; Guidelines as Topic; Humans; Hydrogen Sulfide; Podocytes; P | 2014 |
H₂S and substance P in inflammation.
Topics: Acute Disease; Animals; Burns; Carrageenan; Ceruletide; Disease Models, Animal; Drug Synergism; Edem | 2015 |
Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology.
Topics: Adipose Tissue; Animals; Blood Glucose; Cysteine; Diabetes Mellitus, Type 2; Disease Models, Animal; | 2016 |
Hydrogen Sulfide and Inflammatory Joint Diseases.
Topics: Animals; Arthritis, Rheumatoid; Cells, Cultured; Clinical Trials as Topic; Disease Models, Animal; H | 2017 |
[Hydrogen sulfide (H2S), an endogenous gas with odor of rotten eggs might be a cardiovascular function regulator].
Topics: Animals; Biomedical Research; Cardiovascular Physiological Phenomena; Cardiovascular System; Chromos | 2008 |
Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research.
Topics: Animals; Disease Models, Animal; Homocysteine; Homocystinuria; Humans; Hydrogen Sulfide; Mice; Vascu | 2011 |
Hydrogen sulphide and pain.
Topics: Analgesics; Animals; Calcium Channels, T-Type; Disease Models, Animal; Humans; Hydrogen Sulfide; KAT | 2011 |
Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools.
Topics: Animals; Biomarkers; Cytoprotection; Disease Models, Animal; Humans; Hydrogen Sulfide; Inflammation; | 2011 |
The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule.
Topics: Adrenomedullin; Animals; Biological Factors; Blood Pressure; Cannabinoid Receptor Modulators; Carbon | 2006 |
Hydrogen sulphide--a novel mediator of inflammation?
Topics: Animals; Disease Models, Animal; Humans; Hydrogen Sulfide; Inflammation; Vasodilator Agents | 2006 |
NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizon.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal; | 2007 |
2 trials available for hydrogen sulfide and Disease Models, Animal
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Changes in arterial hydrogen sulfide (H(2)S) content during septic shock and endotoxin shock in rats.
Topics: Analysis of Variance; Animals; Arteries; Blood Glucose; Disease Models, Animal; Hemodynamics; Hydrog | 2003 |
317 other studies available for hydrogen sulfide and Disease Models, Animal
| Article | Year |
|---|---|
Assessment of Inhaled Hydrogen Sulfide in Suppressing Deterioration in Patients With COVID-19.
Topics: Administration, Inhalation; Animals; COVID-19; Disease Models, Animal; Humans; Hydrogen Sulfide; SAR | 2021 |
Hydrogen Sulphide Release via the Angiotensin Converting Enzyme Inhibitor Zofenopril Prevents Intimal Hyperplasia in Human Vein Segments and in a Mouse Model of Carotid Artery Stenosis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Carotid Arteries; Caro | 2022 |
Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Autophagy; Cecum; Cell Line; Disease Models, Animal; Ferroptosis; Hydrog | 2022 |
H
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Asthma; Disease Models, Animal; Humans; | 2022 |
Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia.
Topics: Aging; Alopecia; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Female; Homocystinuri | 2022 |
Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model.
Topics: Animals; Cytochromes c; Disease Models, Animal; Glaucoma; Hydrogen Sulfide; Mitochondria; Neurodegen | 2022 |
Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Encephalomyelitis, Autoimmune, Experimen | 2022 |
Sulfide:quinone oxidoreductase ameliorates neurodegeneration in a murine model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Hydrogen Sulfide; Mice; Parkinson Disease; Quinones; Sulfides | 2023 |
Sulfide:quinone oxidoreductase ameliorates neurodegeneration in a murine model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Hydrogen Sulfide; Mice; Parkinson Disease; Quinones; Sulfides | 2023 |
Sulfide:quinone oxidoreductase ameliorates neurodegeneration in a murine model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Hydrogen Sulfide; Mice; Parkinson Disease; Quinones; Sulfides | 2023 |
Sulfide:quinone oxidoreductase ameliorates neurodegeneration in a murine model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Hydrogen Sulfide; Mice; Parkinson Disease; Quinones; Sulfides | 2023 |
Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome.
Topics: Aging; Animals; Disease Models, Animal; Humans; Hydrogen Sulfide; Lamin Type A; Longevity; Mice; Pro | 2023 |
Hydrogen Sulfide Improves Outcomes in a Murine Model of Necrotizing Enterocolitis via the Cys440 Residue on Endothelial Nitric Oxide Synthase.
Topics: Animals; Disease Models, Animal; Enterocolitis, Necrotizing; Humans; Hydrogen Sulfide; Infant, Newbo | 2023 |
Mental retardation in Down syndrome: Two ways to treat.
Topics: Aminooxyacetic Acid; Animals; Benserazide; Brain; Chromosomes, Human, Pair 21; Cobamides; Cystathion | 2019 |
The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cystathionine gamma-Lyase; Disease Models, Animal; Hydrogen | 2019 |
Hydrogen sulfide potentiates the favorable metabolic effects of inorganic nitrite in type 2 diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, | 2019 |
Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down-modulating PGE
Topics: Animals; Cystathionine beta-Synthase; Cytokines; Dinoprostone; Disease Models, Animal; Drug Toleranc | 2020 |
Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Cognitive Dys | 2020 |
Hydrogen sulfide formation in experimental model of acute pancreatitis.
Topics: Animals; Bile Ducts, Extrahepatic; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-L | 2019 |
A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway.
Topics: Animals; Antioxidants; Cardiotonic Agents; Cystathionine gamma-Lyase; Cysteine; Disease Models, Anim | 2019 |
The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in mice.
Topics: Animals; Carotid Arteries; Carotid Artery, Common; Disease Models, Animal; Hydrogen Sulfide; Male; M | 2020 |
Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis.
Topics: Animals; Copper; Cystathionine beta-Synthase; Cytokines; Disease Models, Animal; Electron Transport | 2020 |
Protective effect of GYY4137, a water‑soluble hydrogen sulfide‑releasing molecule, on intestinal ischemia‑reperfusion.
Topics: Animals; Apoptosis; Biomarkers; Disease Models, Animal; Gene Expression; Hydrogen Sulfide; Immunohis | 2020 |
Evaluation of combined therapeutic effects of hydrogen sulfide donor sodium hydrogen sulfide and phosphodiesterase type-5 inhibitor tadalafil on erectile dysfunction in a partially bladder outlet obstructed rat model.
Topics: Animals; Disease Models, Animal; Erectile Dysfunction; Hydrogen; Hydrogen Sulfide; Male; Muscle, Smo | 2020 |
H
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Disease Models, Animal; Gingiva; Halitosis; Hydrogen | 2019 |
Cysteine becomes conditionally essential during hypobaric hypoxia and regulates adaptive neuro-physiological responses through CBS/H
Topics: Acetylcysteine; Adaptation, Physiological; Adult; Altitude Sickness; Animals; Brain; Cerebrovascular | 2020 |
Anti-inflammatory, antioxidant, and gaso-protective mechanism of 3α-hydroxymasticadienoic acid and diligustilide combination on indomethacin gastric damage.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Dinoprostone; Disease Models, An | 2020 |
Treatment with slow-releasing hydrogen sulfide donors inhibits the nociceptive and depressive-like behaviours accompanying chronic neuropathic pain: Endogenous antioxidant system activation.
Topics: Animals; Antioxidants; Anxiety; Behavior, Animal; Chronic Pain; Depression; Disease Models, Animal; | 2020 |
Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats.
Topics: Amylin Receptor Agonists; Animals; Carbenoxolone; Connexin 43; Diabetic Angiopathies; Diabetic Cardi | 2020 |
LncRNA Oprm1 overexpression attenuates myocardial ischemia/reperfusion injury by increasing endogenous hydrogen sulfide via Oprm1/miR-30b-5p/CSE axis.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Humans; Hydrogen Sulfide; MicroRNAs; Myo | 2020 |
The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model With Underlying Atherosclerosis.
Topics: Animals; Atherosclerosis; Cystathionine gamma-Lyase; Disease Models, Animal; Gene Expression Regulat | 2020 |
Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway.
Topics: Animals; Atrial Fibrillation; Cell Culture Techniques; Diabetes Mellitus, Experimental; Disease Mode | 2020 |
Beneficial effect of sodium thiosulfate extends beyond myocardial tissue in isoproterenol model of infarction: Implication for nootropic effects.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Heart; Hydrogen Sulfide; Isoproterenol; Male; Mit | 2020 |
Diabetic nephropathy associates with deregulation of enzymes involved in kidney sulphur metabolism.
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Models, Animal; Gene Expression | 2020 |
Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function.
Topics: Animals; Diet; Dietary Proteins; Disease Models, Animal; Disease Progression; Escherichia coli; Gast | 2020 |
Anticontractile Effect of Perivascular Adipose Tissue But Not of Endothelium Is Enhanced by Hydrogen Sulfide Stimulation in Hypertensive Pregnant Rat Aortae.
Topics: Adaptation, Physiological; Adipose Tissue; Animals; Aorta, Thoracic; Desoxycorticosterone Acetate; D | 2020 |
Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis.
Topics: Animals; Arthralgia; Cartilage, Articular; Cyclooxygenase 2; Disease Models, Animal; Female; Gene Ex | 2020 |
Periprocedural Hydrogen Sulfide Therapy Improves Vascular Remodeling and Attenuates Vein Graft Disease.
Topics: Anastomosis, Surgical; Animals; Carotid Artery, Common; Disease Models, Animal; Gasotransmitters; Hy | 2020 |
Fetal Hypothyroidism Impairs Aortic Vasorelaxation Responses in Adulthood: Involvement of Hydrogen Sulfide and Nitric Oxide Cross talk.
Topics: Animals; Aorta; Cell Differentiation; Disease Models, Animal; Female; Fetal Diseases; Gasotransmitte | 2021 |
The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice.
Topics: Alkynes; Animals; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Enzyme Inhibitors; Glyci | 2021 |
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Topics: Animals; Apoptosis; Autophagy; Cell Line; Cystathionine gamma-Lyase; Disease Models, Animal; Endopla | 2020 |
Activation of the CaR-CSE/H2S pathway confers cardioprotection against ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Cells, Cultured; Cystathionine gamma-Lyase; Disease Models, Animal; Endothelial | 2021 |
Hydrogen sulfide releasing molecule MZe786 inhibits soluble Flt-1 and prevents preeclampsia in a refined RUPP mouse model.
Topics: Animals; Disease Models, Animal; Female; Hydrogen Sulfide; Mice; Mice, Inbred C57BL; Perfusion; Plac | 2021 |
The mitochondria-targeted hydrogen sulfide donor AP39 improves health and mitochondrial function in a C. elegans primary mitochondrial disease model.
Topics: Adenosine Triphosphate; Animals; Caenorhabditis elegans; Disease Models, Animal; Energy Metabolism; | 2021 |
Design Strategy of Fluorescent Probes for Live Drug-Induced Acute Liver Injury Imaging.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Design; Fluorescent Dy | 2021 |
Exogenous hydrogen sulfide inhibits neutrophils extracellular traps formation via the HMGB1/TLR4/p-38 MAPK/ROS axis in hyperhomocysteinemia rats.
Topics: Animals; Blood Platelets; Disease Models, Animal; Extracellular Traps; HMGB1 Protein; Hydrogen Sulfi | 2021 |
Pre-exposure to hydrogen sulfide modulates the innate inflammatory response to organic dust.
Topics: Animals; Disease Models, Animal; Dust; Humans; Hydrogen Sulfide; Inflammation; Mice | 2021 |
A comparison study of the influence of milk protein versus whey protein in high-protein diets on adiposity in rats.
Topics: Activating Transcription Factor 4; Adipose Tissue; Adiposity; Animals; Antioxidants; Body Weight; Di | 2021 |
A hydrogen sulfide donor suppresses pentylenetetrazol-induced seizures in rats via PKC signaling.
Topics: Animals; Anticonvulsants; Aquaporin 4; Brain Waves; Cytokines; Disease Models, Animal; Hippocampus; | 2021 |
Hydrogen sulphide reduces hyperhomocysteinaemia-induced endothelial ER stress by sulfhydrating protein disulphide isomerase to attenuate atherosclerosis.
Topics: Animals; Atherosclerosis; Cell Line; Disease Models, Animal; Endoplasmic Reticulum Stress; Endotheli | 2021 |
Atorvastatin protects against contrast-induced acute kidney injury via upregulation of endogenous hydrogen sulfide.
Topics: Acute Kidney Injury; Animals; Apoptosis; Atorvastatin; Contrast Media; Cystathionine beta-Synthase; | 2020 |
H
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Line, Tumor; Cell Survival; Cyclic AMP; Cyclic Nu | 2021 |
Ambient hydrogen sulfide exposure increases the severity of influenza A virus infection in swine.
Topics: Animals; Antigens, Viral; Cytokines; Disease Models, Animal; Female; Hydrogen Sulfide; Influenza A V | 2021 |
Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells.
Topics: Amino Acid Transport System y+; Animals; Cell Line, Tumor; Colonic Neoplasms; Cysteine; Deubiquitina | 2021 |
GYY4137 protected the integrity of the blood-brain barrier via activation of the Nrf2/ARE pathway in mice with sepsis.
Topics: Animals; Apoptosis; Biological Transport; Blood-Brain Barrier; Brain; Disease Models, Animal; Hydrog | 2021 |
Hydrogen Sulfide Improves Functional Recovery in Rat Traumatic Spinal Cord Injury Model by Inducing Nuclear Translocation of NF-E2-Related Factor 2.
Topics: Animals; Apoptosis; Disease Models, Animal; Endoplasmic Reticulum Stress; Hydrogen Sulfide; Inflamma | 2021 |
Cystathionine-gamma-lyase deficient mice are protected against the development of multiorgan failure and exhibit reduced inflammatory response during burn.
Topics: Analysis of Variance; Animals; Biomarkers; Blotting, Western; Burns; Cystathionine gamma-Lyase; Cyto | 2017 |
Microvascular Endothelial Dysfunction in Obesity Is Driven by Macrophage-Dependent Hydrogen Sulfide Depletion.
Topics: Adipose Tissue; Animals; Arterioles; Cell Communication; Coculture Techniques; Cystathionine gamma-L | 2017 |
Hydrogen Sulphide Production in Healthy and Ulcerated Gastric Mucosa of Rats.
Topics: Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Gastric Muc | 2017 |
Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Glutathione; Hydrogen Sulfide; Hyperhom | 2017 |
Protective effect of hydrogen sulphide against myocardial hypertrophy in mice.
Topics: Animals; Aorta; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Echocardiography; Heart Failu | 2017 |
Hydrogen Sulfide Confers Lung Protection During Mechanical Ventilation via Cyclooxygenase 2, 15-deoxy Δ12,14-Prostaglandin J2, and Peroxisome Proliferator-Activated Receptor Gamma.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hydrogen Sulfide; Male; Mice; Mice, Inbred C57BL; | 2017 |
Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model.
Topics: Administration, Intravenous; Animals; Antidotes; Apnea; Cobamides; Disease Models, Animal; Female; H | 2017 |
Roles of the Exogenous H2S-Mediated SR-A Signaling Pathway in Renal Ischemia/ Reperfusion Injury in Regulating Endoplasmic Reticulum Stress-Induced Autophagy in a Rat Model.
Topics: Animals; Autophagy; Creatine; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasm | 2017 |
Hydrogen Sulfide Inhibits Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior by Upregulation of Sirt-1: Involvement in Suppression of Hippocampal Endoplasmic Reticulum Stress.
Topics: Animals; Antidepressive Agents; Caspase 12; Depression; Disease Models, Animal; Dose-Response Relati | 2017 |
Protective effects of hydrogen sulfide on portal hypertensive vasculopathy in rabbits by activating AKT-NF-κB pathway.
Topics: Alkynes; Animals; Antihypertensive Agents; Apoptosis; Cystathionine gamma-Lyase; Disease Models, Ani | 2017 |
Hydrogen sulfide protects against the development of experimental cerebral malaria in a C57BL/6 mouse model.
Topics: Animals; Blood-Brain Barrier; Cystathionine beta-Synthase; Disease Models, Animal; Female; Hydrogen | 2017 |
Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury.
Topics: Animals; Autophagy; Disease Models, Animal; Humans; Hydrogen Sulfide; Male; Oxidative Stress; Rats; | 2017 |
The protective effect of hydrogen sulfide (H
Topics: Analysis of Variance; Animals; Brain Injuries, Traumatic; Disease Models, Animal; Hydrogen Sulfide; | 2017 |
Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats.
Topics: Adrenergic Agents; Animals; Behavior, Animal; Cystathionine beta-Synthase; Disease Models, Animal; H | 2017 |
Impaired CBS-H
Topics: Animals; Astrocytes; Cell Line, Tumor; Cells, Cultured; Corpus Striatum; Cystathionine beta-Synthase | 2018 |
Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation.
Topics: Animals; Disease Models, Animal; Gene Expression; Hydrogen Sulfide; Kelch-Like ECH-Associated Protei | 2017 |
GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney.
Topics: Animals; Collagen; Diabetic Nephropathies; Disease Models, Animal; Endothelial Cells; Hydrogen Sulfi | 2017 |
Edoxaban improves venous thrombosis via increasing hydrogen sulfide and homocysteine in rat model.
Topics: Animals; Anticoagulants; Chlorides; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease | 2017 |
Hydrogen Sulfide Protects Retinal Ganglion Cells Against Glaucomatous Injury In Vitro and In Vivo.
Topics: Animals; Disease Models, Animal; Female; Glaucoma; Hydrogen Peroxide; Hydrogen Sulfide; Hydrostatic | 2017 |
Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks.
Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Disease Models, Animal; Endothelial Cel | 2018 |
Changes in hydrogen sulfide in rats with hepatic cirrhosis in different stages.
Topics: Animals; Carbon Tetrachloride; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Model | 2017 |
The administration of hydrogen sulphide prior to ischemic reperfusion has neuroprotective effects in an acute stroke model.
Topics: Animals; Apoptosis; Aspartic Acid; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Humans; Hy | 2017 |
Involvement of adenosine triphosphate-sensitive potassium channels in the neuroprotective activity of hydrogen sulfide in the 6-hydroxydopamine-induced animal model of Parkinson's disease.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dop | 2018 |
Hydrogen sulfide supplement attenuates the apoptosis of retinal ganglion cells in experimental glaucoma.
Topics: Animals; Apoptosis; Autophagy; Disease Models, Animal; Glaucoma; Hydrogen Sulfide; Male; Mitochondri | 2018 |
Endogenous H
Topics: Alkynes; Aminooxyacetic Acid; Analgesics; Animals; Cell Line; Cystathionine gamma-Lyase; Cystitis, I | 2018 |
Porphyromonas gingivalis hydrogen sulfide enhances methyl mercaptan-induced pathogenicity in mouse abscess formation.
Topics: Abscess; Animals; Bacterial Proteins; Bacteroidaceae Infections; Carbon-Sulfur Lyases; Cysteine; Dis | 2018 |
Hydrogen sulfide mediates athero-protection against oxidative stress via S-sulfhydration.
Topics: Animals; Atherosclerosis; Disease Models, Animal; Glutathione Peroxidase; Glutathione Peroxidase GPX | 2018 |
Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H
Topics: Activating Transcription Factor 4; Amino Acids, Sulfur; Animals; Cystathionine gamma-Lyase; Disease | 2018 |
Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat.
Topics: Animals; Apoptosis; Base Sequence; Beclin-1; Cell Line; Disease Models, Animal; Glucose; Humans; Hyd | 2018 |
Novel neuroprotective role of hydrogen sulfide in a rat model of stress brain injury.
Topics: Animals; Brain; Disease Models, Animal; Hydrogen Sulfide; Male; Neuroprotective Agents; Oxidative St | 2018 |
Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure.
Topics: Animals; Biological Availability; Blood Pressure; Cystathionine gamma-Lyase; Disease Models, Animal; | 2018 |
Evaluation of the antiparkinsonism and neuroprotective effects of hydrogen sulfide in acute 6-hydroxydopamine-induced animal model of Parkinson's disease: behavioral, histological and biochemical studies.
Topics: Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopam | 2018 |
Thiol-Activated Hydrogen Sulfide Donors Antiviral and Anti-Inflammatory Activity in Respiratory Syncytial Virus Infection.
Topics: A549 Cells; Administration, Intranasal; Animals; Antiviral Agents; Cytokines; Disease Models, Animal | 2018 |
Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease.
Topics: Adult; Animals; Bacterial Physiological Phenomena; Biofilms; Case-Control Studies; Disease Models, A | 2018 |
Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.
Topics: Aged; Aged, 80 and over; Animals; Atherosclerosis; Carotid Arteries; Carotid Artery Diseases; Cathep | 2019 |
Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis.
Topics: Animals; Cells, Cultured; Corticotropin-Releasing Hormone; Cystathionine beta-Synthase; Diet, High-F | 2018 |
Exogenous hydrogen sulfide attenuates the development of diabetic cardiomyopathy via the FoxO1 pathway.
Topics: Animals; Apoptosis; Diabetic Cardiomyopathies; Disease Models, Animal; Forkhead Box Protein O1; Hear | 2018 |
Evaluation on the effect of hydrogen sulfide on the NLRP3 signaling pathway and its involvement in the pathogenesis of atherosclerosis.
Topics: Animals; Atherosclerosis; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Cell Line, T | 2019 |
CoQ
Topics: Alkyl and Aryl Transferases; Animals; Antioxidants; Ataxia; Disease Models, Animal; HeLa Cells; Huma | 2018 |
Involvement of MicroRNA-133a in the Protective Effect of Hydrogen Sulfide against Ischemia/Reperfusion-Induced Endoplasmic Reticulum Stress and Cardiomyocyte Apoptosis.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Disease Models, Animal; Endoplasmic Reticulum Str | 2019 |
Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer's Disease in Transgenic Mice at Different Ages.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brai | 2019 |
Hydrogen sulfide improves vascular repair by promoting endothelial nitric oxide synthase-dependent mobilization of endothelial progenitor cells.
Topics: Animals; Carotid Artery Injuries; Cell Adhesion; Cell Movement; Cells, Cultured; Disease Models, Ani | 2019 |
Dietary Methionine Restriction Upregulates Endogenous H
Topics: Animals; Body Composition; Body Weight; Cystathionine gamma-Lyase; Diet, High-Fat; Disease Models, A | 2019 |
Composite Graft Pretreatment With Hydrogen Sulfide Delays the Onset of Acute Rejection.
Topics: Acute Disease; Animals; Composite Tissue Allografts; Disease Models, Animal; Graft Rejection; Graft | 2019 |
Inhibiting hydrogen sulfide production in umbilical stem cells reduces their protective effects during experimental necrotizing enterocolitis.
Topics: Animals; Disease Models, Animal; Enterocolitis, Necrotizing; Hydrogen Sulfide; Mesenchymal Stem Cell | 2019 |
Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine γ-lyase.
Topics: Animals; Carotid Artery, Common; Cholesterol, Dietary; Cystathionine gamma-Lyase; Diet, High-Fat; Di | 2020 |
Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.
Topics: Animals; Anti-Inflammatory Agents; Caspase 1; Colitis; Colon; Cystathionine gamma-Lyase; Dextran Sul | 2019 |
Controllable thioester-based hydrogen sulfide slow-releasing donors as cardioprotective agents.
Topics: Animals; Cardiotonic Agents; Cell Line; Disease Models, Animal; Esters; Hydrogen Peroxide; Hydrogen | 2019 |
Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S-sulfhydration in ApoE-knockout atherosclerotic mice.
Topics: Animals; Atherosclerosis; Cells, Cultured; Cystathionine gamma-Lyase; Disease Models, Animal; Dose-R | 2019 |
Acetylcholine- and sodium hydrosulfide-induced endothelium-dependent relaxation and hyperpolarization in cerebral vessels of global cerebral ischemia-reperfusion rat.
Topics: Acetylcholine; Animals; Biological Factors; Cerebral Arteries; Disease Models, Animal; Endothelium, | 2013 |
[Exogenous hydrogen sulfide protects against myocardial injury after skeletal muscle ischemia/reperfusion by inhibiting inflammatory cytokines and oxidative stress in rats].
Topics: Animals; Creatine Kinase, MB Form; Disease Models, Animal; Hydrogen Sulfide; Ischemia; Male; Malondi | 2013 |
Gaseous hydrogen sulfide protects against myocardial ischemia-reperfusion injury in mice partially independent from hypometabolism.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Carbon Dioxide; Cell Line; Disease Models, Anima | 2013 |
Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia.
Topics: Adolescent; Adult; Alkynes; Animals; Antigens, CD; Cells, Cultured; Cystathionine gamma-Lyase; Disea | 2013 |
Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Proliferation; Cystathionine gamma-Lyase; Disease | 2013 |
Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Disease Progression; Hipp | 2013 |
Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice.
Topics: Animals; Benzoates; Biphenyl Compounds; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal | 2013 |
Exogenous hydrogen sulfide prevents kidney damage following unilateral ureteral obstruction.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Fibrosis; Gasotransmitters; Hydrogen Sulfide; | 2014 |
Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis.
Topics: Allyl Compounds; Angiostatins; Animals; Disease Models, Animal; Fibrosis; Heart Failure; Hydrogen Su | 2013 |
Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury.
Topics: Acidosis, Lactic; Adamantane; Adenosine Triphosphate; Alkynes; Animals; Cytokines; Disease Models, A | 2013 |
Cardioprotective effects of a novel hydrogen sulfide agent-controlled release formulation of S-propargyl-cysteine on heart failure rats and molecular mechanisms.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cysteine; Delayed-Action Preparations; Disease Models, Anima | 2013 |
Immunohistochemical approach reveals localization of cystathionine-γ-lyase and cystathionine-β-synthetase in ethanol-induced gastric mucosa damage in mice.
Topics: Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Ethanol; Ga | 2013 |
Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism.
Topics: Animals; Colitis; Colon; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Ani | 2013 |
Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in behavioral models of depression and anxiety.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Disease | 2013 |
Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload.
Topics: Animals; Blotting, Western; Cardiac Volume; Disease Models, Animal; Gene Expression Regulation; Hear | 2013 |
Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats.
Topics: Animals; Choline Deficiency; Cytochrome P-450 CYP2E1; Disease Models, Animal; Disease Progression; F | 2014 |
Pharmacologic attenuation of the hyperdynamic response to supraceliac aortic clamping.
Topics: Animals; Aorta; Arterial Pressure; Cardiac Output; Cardiopulmonary Resuscitation; Cardiotonic Agents | 2015 |
S-propargyl-cysteine, a novel water-soluble modulator of endogenous hydrogen sulfide, promotes angiogenesis through activation of signal transducer and activator of transcription 3.
Topics: Active Transport, Cell Nucleus; Angiogenesis Inducing Agents; Animals; Cell Adhesion; Cell Movement; | 2014 |
Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy.
Topics: Actins; Animals; Cell Line; Cell Proliferation; Collagen; Cystathionine beta-Synthase; Cystathionine | 2014 |
Hydrogen sulfide mitigates reperfusion injury in a porcine model of vascularized composite autotransplantation.
Topics: Allografts; Animals; Aspartate Aminotransferases; Biomarkers; Cytokines; Disease Models, Animal; Gra | 2014 |
Increased protein aggregation in Zucker diabetic fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide.
Topics: Animals; Autophagy; Brain; Diabetes Mellitus, Experimental; Disease Models, Animal; Fibronectins; Gl | 2014 |
Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Hydrogen Sulfide; Magnesium Def | 2014 |
Hydrogen sulfide improves wound healing via restoration of endothelial progenitor cell functions and activation of angiopoietin-1 in type 2 diabetes.
Topics: Angiopoietin-1; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelial Cells; Hydro | 2014 |
Hydrogen sulphide and tempol treatments improve the blood pressure and renal excretory responses in spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Cyclic N-Oxides; Disease Models, Animal; Drinkin | 2014 |
Systemic hydrogen sulfide administration partially restores normal alveolarization in an experimental animal model of bronchopulmonary dysplasia.
Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Cytokines; Disease Models, Animal; Hydrogen S | 2014 |
Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease.
Topics: Adult; Animals; Apoptosis; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models | 2014 |
Exogenous hydrogen sulfide (H2S) protects alveolar growth in experimental O2-induced neonatal lung injury.
Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Disease Models, Animal; Endothelial Cells; Hu | 2014 |
Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis.
Topics: Animals; Apoptosis; Calcium; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase K | 2014 |
The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model.
Topics: Animals; Antidotes; Cobamides; Disease Models, Animal; Hemoglobins; Hydrogen Sulfide; Hydroxocobalam | 2014 |
Dexamethasone ameliorates H₂S-induced acute lung injury by alleviating matrix metalloproteinase-2 and -9 expression.
Topics: Acute Lung Injury; Animals; Cell Line; Dexamethasone; Disease Models, Animal; Glucocorticoids; Hydro | 2014 |
Hydrogen sulfide attenuates the recruitment of CD11b⁺Gr-1⁺ myeloid cells and regulates Bax/Bcl-2 signaling in myocardial ischemia injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; CD11b Antigen; Cell Moveme | 2014 |
Hydrogen sulfide treatment induces angiogenesis after cerebral ischemia.
Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Brain Infarction; Brain Ischemia; Cells, Cul | 2014 |
Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Disease Models, Anim | 2015 |
Hydrogen sulfide endothelin-induced myocardial hypertrophy in rats and the mechanism involved.
Topics: Animals; Cardiomegaly; Collagen; Disease Models, Animal; Endothelins; Heart Ventricles; Hydrogen Sul | 2014 |
Involvement of miR-1 in the protective effect of hydrogen sulfide against cardiomyocyte apoptosis induced by ischemia/reperfusion.
Topics: Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Gene Expression Regulation; Hydrogen S | 2014 |
Central hydrogen sulphide mediates ventilatory responses to hypercapnia in adult conscious rats.
Topics: Aging; Aminooxyacetic Acid; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease | 2014 |
Inorganic-organic hybrid nanoprobe for NIR-excited imaging of hydrogen sulfide in cell cultures and inflammation in a mouse model.
Topics: Animals; Carbocyanines; Coumarins; Disease Models, Animal; Fluorescent Dyes; HeLa Cells; Humans; Hyd | 2014 |
Selective detection of endogenous H₂S in living cells and the mouse hippocampus using a ratiometric fluorescent probe.
Topics: Animals; Carbamates; Cattle; Cystathionine beta-Synthase; Depression; Disease Models, Animal; Down-R | 2014 |
Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice.
Topics: Angiotensin II; Animals; Blood Pressure; Cystathionine gamma-Lyase; Disease Models, Animal; Drug Eva | 2015 |
α-ENaC, a therapeutic target of dexamethasone on hydrogen sulfide induced acute pulmonary edema.
Topics: Animals; Cell Line; Dexamethasone; Disease Models, Animal; Epithelial Sodium Channels; Gene Expressi | 2014 |
Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Celecoxib; Disease Models, Animal; Epi | 2014 |
Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis.
Topics: Analysis of Variance; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; C | 2015 |
Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide.
Topics: Animals; Blood Pressure; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Hydroge | 2014 |
Cytoprotective effects of hydrogen sulfide in novel rat models of non-erosive esophagitis.
Topics: Animals; Cytoprotection; Disease Models, Animal; Esophagitis; Gastroesophageal Reflux; Humans; Hydro | 2014 |
Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Constriction; Disease Mode | 2015 |
Hydrogen sulfide inhalation decreases early blood-brain barrier permeability and brain edema induced by cardiac arrest and resuscitation.
Topics: Administration, Inhalation; Animals; Blood-Brain Barrier; Blotting, Western; Brain Edema; Capillary | 2015 |
Hypoxia disrupts proteostasis in Caenorhabditis elegans.
Topics: Adaptation, Physiological; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Hy | 2015 |
Antioxidant effects of hydrogen sulfide on left ventricular remodeling in smoking rats are mediated via PI3K/Akt-dependent activation of Nrf2.
Topics: Animals; Animals, Newborn; Antioxidants; Cells, Cultured; Cytoprotection; Disease Models, Animal; En | 2015 |
High-dose hydroxocobalamin administered after H2S exposure counteracts sulfide-poisoning-induced cardiac depression in sheep.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Arrest; Hemodynamics; Hydrogen Sulfide; Hydro | 2015 |
Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α.
Topics: Allyl Compounds; Animals; Benzenesulfonates; Colitis; Cystathionine gamma-Lyase; Disease Models, Ani | 2015 |
Impact of carbon monoxide/heme oxygenase on hydrogen sulfide/cystathionine-γ-lyase pathway in the pathogenesis of allergic rhinitis in guinea pigs.
Topics: Air Pollutants; Animals; Antimetabolites; Blotting, Western; Carbon Monoxide; Cystathionine gamma-Ly | 2015 |
Cystathionine-β-Synthase Gene Transfer Into Rostral Ventrolateral Medulla Exacerbates Hypertension via Nitric Oxide in Spontaneously Hypertensive Rats.
Topics: Animals; Blood Pressure; Cystathionine beta-Synthase; Disease Models, Animal; Enzyme Induction; gamm | 2015 |
Exposure to non-steroid anti-inflammatory drugs (NSAIDs) and suppressing hydrogen sulfide synthesis leads to altered structure and impaired function of the oesophagus and oesophagogastric junction.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cystathionine beta-Synthase; Cystathionine gamma-L | 2015 |
Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
Topics: Animals; Cell Line; Cyclic GMP-Dependent Protein Kinases; Cysteine; Diabetes Mellitus; Disease Model | 2015 |
Neuroprotective effects of hydrogen sulfide in Parkinson's disease animal models: methods and protocols.
Topics: Animals; Brain; Disease Models, Animal; Enzyme Assays; Humans; Hydrogen Sulfide; Neuroprotective Age | 2015 |
Effects of Hydrogen Sulfide on Modulation of Theta-Gamma Coupling in Hippocampus in Vascular Dementia Rats.
Topics: Animals; Brain Waves; Dementia, Vascular; Disease Models, Animal; Electrodes, Implanted; Electroence | 2015 |
Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway.
Topics: Animals; Calcium-Binding Proteins; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, | 2015 |
Effect of CCl4 and blocking H2S biosynthesis on oesophageal mucosa rats: model of nonerosive oesophagitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Disease Models, Animal; Enzy | 2014 |
[Effect of intestinal resection on hydrogen sulfide biosynthesis and the damage of Cajal interstitial cells].
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Hydrogen Sulfide; Inflammation; Intersti | 2015 |
H2S induced coma and cardiogenic shock in the rat: Effects of phenothiazinium chromophores.
Topics: Animals; Antidotes; Azure Stains; Biotransformation; Cardiac Output; Cardiotonic Agents; Coma; Disea | 2015 |
Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide.
Topics: Allyl Compounds; Animals; Apoptosis; Cardiomyopathies; Cardiotonic Agents; Cell Line; Cystathionine | 2015 |
Hydrogen Sulfide Signaling in Oxidative Stress and Aging Development.
Topics: Aging; Animals; Disease Models, Animal; Fibrosis; Humans; Hydrogen Sulfide; Oxidative Stress; Protec | 2015 |
Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice.
Topics: Aging; Animals; Cell Survival; Cells, Cultured; Cystathionine beta-Synthase; Cystathionine gamma-Lya | 2015 |
Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC.
Topics: Administration, Inhalation; Animals; Aquaporin 4; Brain; Brain Edema; Disease Models, Animal; Down-R | 2015 |
Cystathionine γ-lyase regulates arteriogenesis through NO-dependent monocyte recruitment.
Topics: Animals; Cystathionine gamma-Lyase; Cytokines; Disease Models, Animal; Hydrogen Sulfide; Ischemia; M | 2015 |
Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation.
Topics: Allografts; Animals; Cell Line, Tumor; Cell Survival; Cold Ischemia; Disease Models, Animal; Graft S | 2015 |
Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Cell Transdifferentiation; Disease Models, An | 2015 |
An exogenous hydrogen sulphide donor, NaHS, inhibits the apoptosis signaling pathway to exert cardio-protective effects in a rat hemorrhagic shock model.
Topics: Animals; Apoptosis; Blotting, Western; Cardiotonic Agents; Disease Models, Animal; Heart; Hemodynami | 2015 |
The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expr | 2015 |
Hydrogen sulphide and mild hypothermia activate the CREB signaling pathway and prevent ischemia-reperfusion injury.
Topics: Analysis of Variance; Animals; Blotting, Western; Brain Injuries; Brain Ischemia; Brain-Derived Neur | 2015 |
[Suppressive effect of hydrogen sulfide donor on endothelin-1 production in aorta of atherosclerotic rats].
Topics: Animals; Aorta; Atherosclerosis; Coronary Vessels; Disease Models, Animal; Endothelin-1; Hydrogen Su | 2015 |
Mild Hypothermia Combined with Hydrogen Sulfide Treatment During Resuscitation Reduces Hippocampal Neuron Apoptosis Via NR2A, NR2B, and PI3K-Akt Signaling in a Rat Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; Hippocampus; | 2016 |
Caffeic Acid Phenethyl Ester inhibit Hepatic Fibrosis by Nitric Oxide Synthase and Cystathionine Gamma-Lyase in Rats.
Topics: Animals; Caffeic Acids; Cystathionine gamma-Lyase; Disease Models, Animal; Enzyme-Linked Immunosorbe | 2015 |
Reducing Ischemia-Reperfusion Injury in Renal Transplantation.
Topics: Animals; Cold Ischemia; Disease Models, Animal; Graft Survival; Hydrogen Sulfide; Kidney Transplanta | 2015 |
Intermittent hypoxia in rats reduces activation of Ca2+ sparks in mesenteric arteries.
Topics: Animals; Calcium Channel Blockers; Calcium Signaling; Disease Models, Animal; Hydrogen Sulfide; Hypo | 2015 |
Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis.
Topics: Amylases; Animals; Blood Chemical Analysis; Ceruletide; Cystathionine gamma-Lyase; Cytokines; Diseas | 2016 |
Effect of the Inhibition of Hydrogen Sulfide Synthesis on Ischemic Injury and Oxidative Stress Biomarkers in a Transient Model of Focal Cerebral Ischemia in Rats.
Topics: Aminooxyacetic Acid; Animals; Biomarkers; Brain; Brain Ischemia; Disease Models, Animal; Enzyme Inhi | 2015 |
Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway.
Topics: Analysis of Variance; Animals; Biomarkers; Blotting, Western; Coxsackievirus Infections; Cystathioni | 2015 |
A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzenesulfonates; Colon; Disease Models, Animal; Hydrogen | 2016 |
A Fast Hydrogen Sulfide-Releasing Donor Increases the Tumor Response to Radiotherapy.
Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Femal | 2016 |
Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Inhalation; Animals; Brain Infarction; Deoxyguanosine; | 2016 |
Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.
Topics: Acute Lung Injury; Alkynes; Angiopoietin-2; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Con | 2017 |
Sulfate-reducing bacteria impairs working memory in mice.
Topics: Animals; Bartonella Infections; Disease Models, Animal; Dose-Response Relationship, Drug; Gasotransm | 2016 |
Post-stroke gaseous hypothermia increases vascular density but not neurogenesis in the ischemic penumbra of aged rats.
Topics: Aging; Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Doublecortin Domain Protei | 2016 |
Cystathionine γ lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor γ activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Anti-Obesity Agents; Cystathionine gamma-Lyase; Cys | 2016 |
Cystathionine-γ-lyase gene silencing with siRNA in monocytes/ macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Gene Silencing; Humans; Hydrogen Sulfide | 2016 |
Exogenous hydrogen sulphide ameliorates diabetic cardiomyopathy in rats by reversing disordered calcium-handling system in sarcoplasmic reticulum.
Topics: Animals; Calcium; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal | 2016 |
Hydrogen sulfide depletion contributes to microvascular remodeling in obesity.
Topics: Alkynes; Animals; Arterioles; Cells, Cultured; Collagen; Collagenases; Cystathionine gamma-Lyase; Di | 2016 |
Hydrogen Sulfide Attenuates Tissue Plasminogen Activator-Induced Cerebral Hemorrhage Following Experimental Stroke.
Topics: Analysis of Variance; Animals; Brain Edema; Brain Infarction; Cells, Cultured; Cerebral Hemorrhage; | 2016 |
Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress.
Topics: Animals; Aorta; Cholecalciferol; Disease Models, Animal; Endoplasmic Reticulum Stress; Hydrogen Sulf | 2016 |
Hydrosulfide attenuates acute myocardial ischemic injury through the glycogen synthase kinase-3β/β-catenin signaling pathway.
Topics: Animals; Apoptosis; beta Catenin; Biomarkers; Blood Pressure; Disease Models, Animal; Glycogen Synth | 2016 |
Sodium Sulfide Attenuates Ischemic-Induced Heart Failure by Enhancing Proteasomal Function in an Nrf2-Dependent Manner.
Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Endoplasmic Reticulum Stress; Heart Failure; | 2016 |
Decreased vascular H2S production is associated with vascular oxidative stress in rats fed a high-fat western diet.
Topics: Animals; Aorta; Cystathionine gamma-Lyase; Diet, High-Fat; Diet, Western; Disease Models, Animal; Do | 2016 |
pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury.
Topics: Animals; Disease Models, Animal; Hydrogen Sulfide; Hydrogen-Ion Concentration; Mice; Myocardial Repe | 2016 |
H2S Regulates Hypobaric Hypoxia-Induced Early Glio-Vascular Dysfunction and Neuro-Pathophysiological Effects.
Topics: Altitude Sickness; Animals; Cerebrovascular Circulation; Cognitive Dysfunction; Disease Models, Anim | 2016 |
Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model.
Topics: Animals; Blood Glucose; Body Weight; Cardiotonic Agents; Diabetic Cardiomyopathies; Disease Models, | 2016 |
The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Line, Transformed; Chromans; Co | 2016 |
Role of central hydrogen sulfide on ventilatory and cardiovascular responses to hypoxia in spontaneous hypertensive rats.
Topics: Animals; Arterial Pressure; Cardiovascular Agents; Cardiovascular System; Disease Models, Animal; Fo | 2016 |
Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy.
Topics: Animals; Blotting, Western; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, | 2016 |
Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages.
Topics: Animals; Disease Models, Animal; Fatty Acids; Heart Function Tests; Hydrogen Sulfide; Lipolysis; Mac | 2016 |
Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse.
Topics: ADAM17 Protein; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anim | 2016 |
Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137.
Topics: Animals; Cytoprotection; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Glycoge | 2016 |
Novel phenanthridine (PHE-4i) derivative inhibits carrageenan-induced rat hind paw oedema through suppression of hydrogen sulfide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Edema; Hydrog | 2016 |
Hydrogen Sulfide, a Potential Cardioprotective Gas Activating a Life Span Regulator.
Topics: Animals; Biomarkers; Cardiotonic Agents; Disease Models, Animal; Evidence-Based Medicine; Humans; Hy | 2016 |
Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury.
Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Hydrogen Sulfide; Lung; Microbubbles; Myocar | 2016 |
Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain Diseases; Brain-Derived Neurotrophic Factor; C | 2016 |
H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.
Topics: Animals; Carotid Body; Cystathionine gamma-Lyase; Disease Models, Animal; Heme Oxygenase (Decyclizin | 2016 |
GluN2B-containing NMDA receptors contribute to the beneficial effects of hydrogen sulfide on cognitive and synaptic plasticity deficits in APP/PS1 transgenic mice.
Topics: Amyloid beta-Peptides; Animals; Disease Models, Animal; Hydrogen Sulfide; Long-Term Potentiation; Ma | 2016 |
Synthesis and biological evaluation of novel hydrogen sulfide releasing nicotinic acid derivatives.
Topics: Animals; Brain Ischemia; Cell Line; Cell Survival; Disease Models, Animal; Dose-Response Relationshi | 2016 |
S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway.
Topics: Anemia; Animals; Cysteine; Disease Models, Animal; Hepcidins; Hydrogen Sulfide; Inflammation; Interl | 2016 |
Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase.
Topics: Animals; Biomarkers; Blood Urea Nitrogen; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cy | 2016 |
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Disease Models, Animal; DNA | 2016 |
Cystathionine γ-Lyase Deficiency Exacerbates CCl
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2017 |
Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model.
Topics: Animals; Cell Survival; Cells, Cultured; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Dis | 2017 |
Hydrogen Sulfide Ameliorates Homocysteine-Induced Cognitive Dysfunction by Inhibition of Reactive Aldehydes Involving Upregulation of ALDH2.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Animals; Cognition Disorders; Disease Models, Anim | 2017 |
Hydrogen Sulfide Promotes Learning and Memory and Suppresses Proinflammatory Cytokines in Repetitive Febrile Seizures.
Topics: Animals; Animals, Newborn; CD11b Antigen; Cytokines; Disease Models, Animal; Electroencephalography; | 2016 |
Metabolic, Cardiac, and Renal Effects of the Slow Hydrogen Sulfide-Releasing Molecule GYY4137 During Resuscitated Septic Shock in Swine with Pre-Existing Coronary Artery Disease.
Topics: Animals; Coronary Artery Disease; Delayed-Action Preparations; Disease Models, Animal; Heart; Hydrog | 2017 |
Rapid Antidepressant Effect of Hydrogen Sulfide: Evidence for Activation of mTORC1-TrkB-AMPA Receptor Pathways.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Disease Models, Animal; Gene Expression | 2017 |
Cystathionine γ-Lyase-Hydrogen Sulfide Induces Runt-Related Transcription Factor 2 Sulfhydration, Thereby Increasing Osteoblast Activity to Promote Bone Fracture Healing.
Topics: Animals; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Cystathionine gamma-Lyase; Disea | 2017 |
Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Progression; Gastric Mucosa; Gene Expression; H | 2017 |
Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
Topics: Activating Transcription Factor 4; Activating Transcription Factors; Animals; Apolipoprotein B-100; | 2017 |
Age-Dependent Allergic Asthma Development and Cystathionine Gamma-Lyase Deficiency.
Topics: Age Factors; Animals; Asthma; Cells, Cultured; Cystathionine gamma-Lyase; Cytokines; Disease Models, | 2017 |
Hydrogen sulfide as an oxygen sensor in trout gill chemoreceptors.
Topics: Animals; Cells, Cultured; Chemoreceptor Cells; Cystathionine beta-Synthase; Cystathionine gamma-Lyas | 2008 |
Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Cytoprotection; | 2008 |
Surviving blood loss using hydrogen sulfide.
Topics: Administration, Inhalation; Air Pollutants; Animals; Disease Models, Animal; Hemorrhage; Hydrogen Su | 2008 |
Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cystathionine gamma-Lyase; Disease Models, Animal; Hyd | 2008 |
Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice.
Topics: Active Transport, Cell Nucleus; Alkynes; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Body We | 2009 |
Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cystathionine gamma-Lyase; Disease Models, Animal; En | 2009 |
Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels.
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cerebellum; Disea | 2009 |
Hydrogen sulfide triggers late-phase preconditioning in postischemic small intestine by an NO- and p38 MAPK-dependent mechanism.
Topics: Animals; Anti-Inflammatory Agents; Cell Adhesion; Disease Models, Animal; Enzyme Inhibitors; Hydroge | 2009 |
[Interaction between endogenous cystathionine synthase/hydrogen sulfide and heme oxygenase-1/carbon monoxide systems during myocardial ischemic-reperfusion: experiment with rats].
Topics: Animals; Carbon Monoxide; Cystathionine beta-Synthase; Disease Models, Animal; Heme Oxygenase (Decyc | 2008 |
Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione Peroxidase; Hydrogen Sulfide; Intestinal | 2009 |
Blood pressure control: hydrogen sulfide, a new gasotransmitter, takes stage.
Topics: Animals; Autocrine Communication; Blood Pressure; Cystathionine gamma-Lyase; Disease Models, Animal; | 2009 |
[Role of hydrogen sulfide/cystathionine-gamma-lyase system in acute lung injury induced by lipopolysaccharide in rats].
Topics: Acute Lung Injury; Animals; Carbon Monoxide; Cystathionine gamma-Lyase; Disease Models, Animal; Heme | 2009 |
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Colitis; Cyclooxygenase 1; Cyclooxygenase | 2009 |
Ischemia-reperfusion reduces cystathionine-beta-synthase-mediated hydrogen sulfide generation in the kidney.
Topics: Animals; Apoptosis; Cyclic N-Oxides; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease | 2009 |
Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure.
Topics: Animals; Antioxidants; Apoptosis; Cystathionine beta-Synthase; Desmin; Disease Models, Animal; Gluta | 2009 |
A single application of hydrogen sulphide induces a transient osteoclast differentiation with RANKL expression in the rat model.
Topics: Acid Phosphatase; Administration, Topical; Alveolar Process; Animals; Biomarkers; Cell Differentiati | 2009 |
S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway.
Topics: Animals; Animals, Newborn; Cell Hypoxia; Cell Survival; Cystathionine gamma-Lyase; Cysteine; Disease | 2009 |
[Mechanism of endogenous carbon monoxide effect on hydrogen sulfide in guinea pigs with established allergic rhinitis].
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Guinea Pigs; Heme Oxygenase-1; Hydrogen Sulfide; I | 2009 |
Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Survival; Coronary Circulation; Disease Models, Animal; | 2009 |
Hydrogen sulfide-induced hypometabolism prevents renal ischemia/reperfusion injury.
Topics: Adaptation, Physiological; Air Pollutants; Animals; Disease Models, Animal; Energy Metabolism; Hiber | 2009 |
Cardioprotective effect of hydrogen sulfide in ischemic reperfusion experimental rats and its influence on expression of survivin gene.
Topics: Alkynes; Animals; Apoptosis; Blood Pressure; Blotting, Western; Cardiotonic Agents; Cystathionine ga | 2009 |
The dual role of the cystathionine gamma-lyase/hydrogen sulfide pathway in CVB3-induced myocarditis in mice.
Topics: Animals; Coxsackievirus Infections; Cystathionine gamma-Lyase; Disease Models, Animal; HeLa Cells; H | 2009 |
[Role of polymorphonuclear neutrophil in exogenous hydrogen sulfide attenuating endotoxin-induced acute lung injury].
Topics: Acute Lung Injury; Animals; Apoptosis; Disease Models, Animal; Humans; Hydrogen Sulfide; Lipopolysac | 2009 |
ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture.
Topics: Animals; Blotting, Western; Caspases; Cells, Cultured; Disease Models, Animal; Electrophoresis, Poly | 2010 |
Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Blotting, Western; Burns; Cytochromes c; Disease Models, Animal; Enzyme- | 2009 |
Hydrogen sulphide: an increasing need for scientific equipoise.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Disease Models, Animal; Dose-Response Relationshi | 2009 |
H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure.
Topics: ADAM Proteins; ADAM12 Protein; Animals; Antioxidants; Apoptosis; Chronic Disease; Disease Models, An | 2010 |
Strategies to improve post-stroke behavioral recovery in aged subjects.
Topics: Aging; Animals; Behavior; Brain; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Feedba | 2009 |
Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Cell Line; Cell Line, Tumor; Disease Models, Anim | 2010 |
L-cysteine stimulates hydrogen sulfide synthesis in myocardium associated with attenuation of ischemia-reperfusion injury.
Topics: Alkynes; Analysis of Variance; Animals; Cysteine; Disease Models, Animal; Drug Therapy, Combination; | 2010 |
Hydrogen sulfide inhibits plasma renin activity.
Topics: Adenylyl Cyclases; Animals; Blood Pressure; Cells, Cultured; Colforsin; Cyclic AMP; Disease Models, | 2010 |
Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blood Pressure; Cardiotonic Agents; Caspase 3; Cytoc | 2011 |
Dynamic change of hydrogen sulfide during global cerebral ischemia-reperfusion and its effect in rats.
Topics: Animals; Blotting, Western; Brain Ischemia; Central Nervous System Agents; Cerebral Cortex; Cystathi | 2010 |
Hydrogen sulfide attenuates ischemia-reperfusion injury in in vitro and in vivo models of intestine free tissue transfer.
Topics: Animals; Cell Line; Cell Survival; Cytoprotection; Disease Models, Animal; Enterocytes; Hydrogen Sul | 2010 |
Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain.
Topics: Analgesia; Analgesics; Animals; Cell Line; Disease Models, Animal; Humans; Hydrogen Sulfide; KATP Ch | 2010 |
Inhaled hydrogen sulfide protects against ventilator-induced lung injury.
Topics: Administration, Inhalation; Animals; Apoptosis; Biomarkers; Blotting, Western; Bronchoalveolar Lavag | 2010 |
Inhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage.
Topics: Alkynes; Animals; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Enzyme Inhibitors; Glyci | 2011 |
Hydrogen sulfide attenuates intestinal ischemia-reperfusion injury when delivered in the post-ischemic period.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen Sulfide | 2010 |
Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Inhalation; Animals; Apoptosis; Base S | 2011 |
[Protection of CSE/H2S system in hepatic ischemia reperfusion injury in rats].
Topics: Animals; Apoptosis; Cystathionine gamma-Lyase; Disease Models, Animal; Hydrogen Sulfide; Interleukin | 2010 |
Mechanisms of action of the gasotransmitter hydrogen sulfide in modulating contractile activity of longitudinal muscle of rat ileum.
Topics: Animals; Disease Models, Animal; Gastrointestinal Motility; Hydrogen Sulfide; Ileum; KATP Channels; | 2011 |
Hydrogen sulfide: from physiology to pharmacology.
Topics: Animals; Anti-Inflammatory Agents; Cysteine; Disease Models, Animal; Drug Design; Humans; Hydrogen S | 2011 |
Chelating luminal zinc mimics hydrogen sulfide-evoked colonic pain in mice: possible involvement of T-type calcium channels.
Topics: Abdominal Pain; Animals; Calcium Channels, T-Type; Chelating Agents; Colon; Disease Models, Animal; | 2011 |
Interaction between hydrogen sulfide and nitric oxide on cardiac protection in rats with metabolic syndrome.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Heart; Hydrogen Sulfide; Male; Metabolic | 2011 |
Myocardial and lung injuries induced by hydrogen sulfide and the effectiveness of oxygen therapy in rats.
Topics: Acute Lung Injury; Air Pollutants; Alveolar Epithelial Cells; Animals; Blood Gas Analysis; Cardiomyo | 2011 |
Hydrogen sulfide and asthma.
Topics: Airway Remodeling; Animals; Asthma; Biomarkers; Bronchoconstriction; Cystathionine beta-Synthase; Cy | 2011 |
Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of heme oxygenase-1.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Cell Adhesion; Disease Models, Animal; Dose | 2011 |
Effects of hydrogen sulfide synthesis inhibitors on posthypoxic ventilatory behavior in the C57BL/6J mouse.
Topics: Animals; Disease Models, Animal; Guanidines; Hydrogen Sulfide; Hydroxylamine; Male; Mice; Mice, Inbr | 2011 |
[Effect of hydrogen sulfide-induced delayed preconditioning on glutathione S-transferase expression during myocardial ischemia-reperfusion in rats].
Topics: Animals; Disease Models, Animal; Glutathione Transferase; Hydrogen Sulfide; Ischemic Preconditioning | 2011 |
Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease.
Topics: Animals; Biomarkers; Blood Pressure Determination; Blotting, Western; Brain; Disease Models, Animal; | 2012 |
Effects of hydrogen sulfide on a rat model of sepsis-associated encephalopathy.
Topics: Aminooxyacetic Acid; Animals; Brain Diseases; Cystathionine beta-Synthase; Cytokines; Disease Models | 2011 |
Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfide.
Topics: Animals; Apoptosis; Benzoates; Cell Survival; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyst | 2012 |
Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in mice.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Cysteine; Cyt | 2012 |
Metabolic and cardiac signaling effects of inhaled hydrogen sulfide and low oxygen in male rats.
Topics: Administration, Inhalation; Animals; Body Temperature Regulation; Creatine Kinase, MB Form; Disease | 2012 |
Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hydrogen Sulfide; Lung Transplantation; Perfusion; | 2012 |
Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia.
Topics: Aging; Animals; Annexin A1; Blotting, Western; Brain; Brain Ischemia; Disease Models, Animal; Electr | 2012 |
Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice.
Topics: Acetanilides; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclophos | 2012 |
Protective role of methionine sulfoxide reductase A against ischemia/reperfusion injury in mouse kidney and its involvement in the regulation of trans-sulfuration pathway.
Topics: Animals; Antigens, Ly; Disease Models, Animal; Enzyme Activation; Gene Deletion; Gene Expression Reg | 2013 |
An exogenous hydrogen sulphide donor, NaHS, inhibits the nuclear factor κB inhibitor kinase/nuclear factor κb inhibitor/nuclear factor-κB signaling pathway and exerts cardioprotective effects in a rat hemorrhagic shock model.
Topics: Animals; Cardiotonic Agents; Creatine Kinase; Disease Models, Animal; Hydrogen Sulfide; I-kappa B Ki | 2012 |
Distribution of hydrogen sulfide (H₂S)-producing enzymes and the roles of the H₂S donor sodium hydrosulfide in diabetic nephropathy.
Topics: Animals; Calmodulin; Capillaries; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diabetes M | 2013 |
Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in β-amyloid rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Hippocampus; Hydrogen Sul | 2012 |
Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aorta, Thoracic; Arginine; Disease Models, Animal; Endothelium, Vascular; Hydrogen Sulfide; | 2013 |
Detrimental effects of prolonged warm renal ischaemia-reperfusion injury are abrogated by supplemental hydrogen sulphide: an analysis using real-time intravital microscopy and polymerase chain reaction.
Topics: Animals; Biomarkers; Dietary Supplements; Disease Models, Animal; Hydrogen Sulfide; Kidney; Kidney T | 2012 |
Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice.
Topics: Animals; Apolipoproteins E; Aspirin; Atherosclerosis; Brachiocephalic Trunk; Cell Line; Chemotaxis; | 2012 |
[Effects of hydrogen sulfide preconditioning on myocardial ischemia reperfusion injury in rats].
Topics: Animals; Disease Models, Animal; Hydrogen Sulfide; Ischemic Preconditioning, Myocardial; Male; Myoca | 2012 |
Protective effects of hydrogen sulfide on oxidative stress and fibrosis in hepatic stellate cells.
Topics: Animals; Apoptosis; Calcium; Cell Line; Cell Proliferation; Collagen Type I; Cytoplasm; Disease Mode | 2013 |
Effects of hydrogen sulphide in an experimental model of renal ischaemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Biomarkers; Constriction; Creatinine; Disease Models, Animal; Female; | 2012 |
Hydrogen sulfide inhibits preoptic prostaglandin E2 production during endotoxemia.
Topics: Animals; Dinoprostone; Disease Models, Animal; Endotoxemia; Fever; Hydrogen Sulfide; Male; Preoptic | 2013 |
Supplemental hydrogen sulphide protects transplant kidney function and prolongs recipient survival after prolonged cold ischaemia-reperfusion injury by mitigating renal graft apoptosis and inflammation.
Topics: Animals; Apoptosis; Dietary Supplements; Disease Models, Animal; Graft Survival; Hydrogen Sulfide; I | 2012 |
Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes.
Topics: 3T3-L1 Cells; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2013 |
Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.
Topics: Active Transport, Cell Nucleus; Animals; Cardiotonic Agents; Disease Models, Animal; Genes, Reporter | 2013 |
The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells.
Topics: Acute Disease; Animals; Arthritis; Cartilage; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Cytok | 2013 |
Hydrogen sulfide may improve the hippocampal damage induced by recurrent febrile seizures in rats.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; Hippocampus; Hydrogen Sulfide; Immunoh | 2005 |
Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia.
Topics: Alanine Transaminase; Alkynes; Analysis of Variance; Animals; Blood Pressure; Chemotaxis, Leukocyte; | 2005 |
The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis.
Topics: Animals; Base Sequence; Carbon Tetrachloride Poisoning; Cystathionine gamma-Lyase; Disease Models, A | 2005 |
Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats.
Topics: Animals; Disease Models, Animal; Hippocampus; Hydrogen Sulfide; Hydroxylamine; Immunohistochemistry; | 2005 |
Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Cloning, Molecular; Cyst | 2005 |
Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse.
Topics: Alkynes; Animals; Cecum; Disease Models, Animal; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Liver | 2006 |
High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Animals; Brain; Cysteine; Cystine; Disease Models, Anim | 2006 |
[Impact of hydrogen sulfide donor on pulmonary vascular structure and vasoactive peptides in rats with pulmonary hypertension induced by high pulmonary blood flow].
Topics: Animals; Atrial Natriuretic Factor; Calcitonin Gene-Related Peptide; Disease Models, Animal; Endothe | 2006 |
Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats.
Topics: Alkynes; Animals; Cell Death; Cells, Cultured; Culture Media; Cystathionine gamma-Lyase; Disease Mod | 2007 |
Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB.
Topics: Alkynes; Animals; Cecum; Chemokines; Cystathionine gamma-Lyase; Cytokines; Disease Models, Animal; G | 2007 |
Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Chemokines; Colitis; Colon; Cytokines; Disease Models, Animal; Di | 2007 |
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dinoprostone; Disease Mod | 2007 |
Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Diclofenac; Disease Models, Animal; Hy | 2008 |
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.
Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Cell Survival; Chromones; Disease Models, Animal; | 2008 |
The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow.
Topics: Alkynes; Animals; Aorta, Abdominal; Arteriovenous Shunt, Surgical; Carbon Monoxide; Cystathionine ga | 2007 |
Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats.
Topics: Adrenocorticotropic Hormone; Animals; Body Temperature; Caspase 12; Corticosterone; Disease Models, | 2008 |
[The regulatory effect of endogenous hydrogen sulfide on acute asthma].
Topics: Animals; Asthma; Cystathionine gamma-Lyase; Disease Models, Animal; Hydrogen Sulfide; Lung; Male; Ov | 2007 |
Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Electron Transport Complex IV; Endoplasm | 2008 |
The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats.
Topics: Acetylcholine; Animals; Disease Models, Animal; Homocysteine; Hydrogen Sulfide; Hyperhomocysteinemia | 2008 |
Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation.
Topics: Animals; Burns; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hydrogen Sulfide; Infl | 2008 |
Long-term hypothermia reduces infarct volume in aged rats after focal ischemia.
Topics: Aging; Animals; Apoptosis; Apoptosis Regulatory Proteins; Body Temperature; Brain; Brain Infarction; | 2008 |