Page last updated: 2024-10-17

hydrogen sulfide and Disease Exacerbation

hydrogen sulfide has been researched along with Disease Exacerbation in 29 studies

Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.

Research Excerpts

ExcerptRelevanceReference
"Literature was collected from PubMed until February 2019, using the search terms including "Hydrogen sulfide," "Chronic kidney disease," "Renal interstitial fibrosis," "Kidney disease," "Inflammation factor," "Oxidative stress," "Epithelial-to-mesenchymal transition," "H2S donor," "Hypertensive kidney dysfunction," "Myofibroblasts," "Vascular remodeling," "transforming growth factor (TGF)-beta/Smads signaling," and "Sulfate potassium channels."9.01Involvement of hydrogen sulfide in the progression of renal fibrosis. ( Huang, L; Peng, ZZ; Qin, J; Tang, WB; Tao, LJ; Tu, JK; Wang, W; Wang, Y; Xiao, XC; Xie, YY; Xing, QQ; Xu, H; Yuan, QJ; Yuan, XN, 2019)
"Glaucoma is an irreversible and blinding neurodegenerative disease of the eye, and is characterized by progressive loss of retinal ganglion cells (RGCs)."5.46Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model. ( Guo, L; Huang, P; Huang, S; Leung, CK; Lin, Z; Liu, X; Wang, J; Xu, S; Zhong, Y, 2017)
"Hydrogen sulfide (H2S) is a gaseous mediator that promotes tissue repair and resolution of inflammation."5.40Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis. ( Agbor, TA; Blackler, RW; Ferraz, JG; Flannigan, KL; Khan, WI; Kim, JJ; Verdu, EF; Wallace, JL, 2014)
"Literature was collected from PubMed until February 2019, using the search terms including "Hydrogen sulfide," "Chronic kidney disease," "Renal interstitial fibrosis," "Kidney disease," "Inflammation factor," "Oxidative stress," "Epithelial-to-mesenchymal transition," "H2S donor," "Hypertensive kidney dysfunction," "Myofibroblasts," "Vascular remodeling," "transforming growth factor (TGF)-beta/Smads signaling," and "Sulfate potassium channels."5.01Involvement of hydrogen sulfide in the progression of renal fibrosis. ( Huang, L; Peng, ZZ; Qin, J; Tang, WB; Tao, LJ; Tu, JK; Wang, W; Wang, Y; Xiao, XC; Xie, YY; Xing, QQ; Xu, H; Yuan, QJ; Yuan, XN, 2019)
"Transient molecules in the gastrointestinal tract such as nitric oxide and hydrogen sulfide are key signals and mediators of inflammation."4.31Sub-1.4 cm ( Ahn, J; Chandrakasan, AP; Fabian, N; Hayward, A; Inda-Webb, ME; Ishida, K; Jenkins, J; Jimenez, M; Kuosmanen, J; Lai, Y; Liu, Q; Lu, TK; Madani, W; McNally, R; Mimee, M; Nadeau, P; Phan, NV; Riaz, A; Steiger, C; Traverso, G; Wentworth, A; Wong, K; Yazicigil, RT; Zirtiloglu, T, 2023)
" The potential for HNF4α to regulate SBP1 expression was supported by data indicating that HNF4α inhibition resulted in a dose-response increase in the levels of SBP1 messenger RNA and protein, identifying HNF4α as a novel negative regulator of SBP1 expression in prostate cancer cells."1.56Selenium-binding protein 1 alters energy metabolism in prostate cancer cells. ( Diamond, AM; Elhodaky, M; Hong, LK; Kadkol, S, 2020)
"Prenatal treatment of Down syndrome fetuses is also suggested."1.51Mental retardation in Down syndrome: Two ways to treat. ( Kamoun, PP, 2019)
"Patients with chronic obstructive pulmonary disease and non-alcoholic steatohepatitis, which developed against the background of obesity, are characterized by a significant increase in the synthesis of collagen and glycoproteins, which was accompanied by an ineffective resorption of newly formed collagen against the background of substantial activation of proteinase inhibitors (α2-MG), accompanied by the hyperproduction of nitrogen monoxide, endothelin-1, hyperlipidemia, deficiency of hydrogen sulfide liberation."1.51The role of hydrogen sulfide in the progression of chronic obstructive pulmonary disease in patients with non-alcoholic steatohepatitis ( Dudka, IV; Dudka, TV; Hryniuk, OY; Khukhlina, OS; Kovalenko, SV; Mandry, OY, 2019)
"Glaucoma is an irreversible and blinding neurodegenerative disease of the eye, and is characterized by progressive loss of retinal ganglion cells (RGCs)."1.46Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model. ( Guo, L; Huang, P; Huang, S; Leung, CK; Lin, Z; Liu, X; Wang, J; Xu, S; Zhong, Y, 2017)
"Hydrogen sulfide (H₂S) is an endogenous mediator, synthesized from l-cysteine by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) or 3-mercaptopyruvate sulfurtransferase (3-MST)."1.46Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations. ( Brzozowski, T; Ginter, G; Hubalewska-Mazgaj, M; Kwiecien, S; Magierowska, K; Magierowski, M; Pajdo, R; Sliwowski, Z, 2017)
"Hydrogen sulfide (H2S) is a gaseous mediator that promotes tissue repair and resolution of inflammation."1.40Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis. ( Agbor, TA; Blackler, RW; Ferraz, JG; Flannigan, KL; Khan, WI; Kim, JJ; Verdu, EF; Wallace, JL, 2014)
"Hydrogen sulfide (H(2)S) has recently been found to play beneficial roles in ameliorating several diseases, including hypertension, atherosclerosis and cardiac/renal ischemia-reperfusion injuries."1.39Distribution of hydrogen sulfide (H₂S)-producing enzymes and the roles of the H₂S donor sodium hydrosulfide in diabetic nephropathy. ( Imai, E; Kimura, T; Kojima, H; Kosugi, T; Maruyama, S; Matsuo, S; Niki, I; Sato, W; Taniguchi, S; Yamamoto, J; Yamamoto, T; Yuzawa, Y, 2013)
"Hydrogen sulfide (H(2)S) is an endogenous signaling gas, which possesses potent anti-oxidant, anti-inflammatory, anti-hypertensive and other regulatory functions."1.38Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease. ( Aminzadeh, MA; Vaziri, ND, 2012)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's25 (86.21)24.3611
2020's4 (13.79)2.80

Authors

AuthorsStudies
Inda-Webb, ME1
Jimenez, M1
Liu, Q1
Phan, NV1
Ahn, J1
Steiger, C1
Wentworth, A1
Riaz, A1
Zirtiloglu, T1
Wong, K1
Ishida, K1
Fabian, N1
Jenkins, J1
Kuosmanen, J1
Madani, W1
McNally, R1
Lai, Y1
Hayward, A1
Mimee, M1
Nadeau, P1
Chandrakasan, AP1
Traverso, G1
Yazicigil, RT1
Lu, TK1
Kamoun, PP1
Wang, YH1
Huang, JT1
Chen, WL1
Wang, RH1
Kao, MC1
Pan, YR1
Chan, SH1
Tsai, KW1
Kung, HJ1
Lin, KT1
Wang, LH1
Wang, Y3
Xing, QQ1
Tu, JK1
Tang, WB1
Yuan, XN1
Xie, YY1
Wang, W1
Peng, ZZ1
Huang, L1
Xu, H1
Qin, J1
Xiao, XC1
Tao, LJ1
Yuan, QJ1
Khukhlina, OS1
Hryniuk, OY1
Dudka, IV1
Kovalenko, SV1
Dudka, TV1
Mandry, OY1
Elhodaky, M1
Hong, LK1
Kadkol, S1
Diamond, AM1
Lobel, L1
Cao, YG1
Fenn, K1
Glickman, JN1
Garrett, WS1
Minaei, A1
Sarookhani, MR1
Haghdoost-Yazdi, H1
Rajaei, F1
Han, SJ2
Noh, MR1
Jung, JM1
Ishii, I1
Yoo, J1
Kim, JI2
Park, KM2
Suzuki, Y1
Saito, J1
Kikuchi, M1
Uematsu, M1
Fukuhara, A1
Sato, S1
Munakata, M1
Kuang, Q1
Xue, N1
Chen, J1
Shen, Z1
Cui, X1
Fang, Y1
Ding, X1
Bibli, SI1
Hu, J1
Sigala, F1
Wittig, I1
Heidler, J1
Zukunft, S1
Tsilimigras, DI1
Randriamboavonjy, V1
Wittig, J1
Kojonazarov, B1
Schürmann, C1
Siragusa, M1
Siuda, D1
Luck, B1
Abdel Malik, R1
Filis, KA1
Zografos, G1
Chen, C1
Wang, DW1
Pfeilschifter, J1
Brandes, RP1
Szabo, C1
Papapetropoulos, A2
Fleming, I1
Aytekin, K1
Erhan, SŞ1
Erişgin, Z1
Esenyel, CZ1
Takır, S1
Giuliani, D1
Ottani, A1
Zaffe, D1
Galantucci, M1
Strinati, F1
Lodi, R1
Guarini, S1
Jung, KJ1
Jang, HS1
Park, JW1
Luo, ZL1
Tang, LJ1
Wang, T1
Dai, RW1
Ren, JD1
Cheng, L1
Xiang, K1
Tian, FZ1
Kirkham, PA1
Whiteman, M1
Winyard, PG1
Caramori, G1
Gordon, F1
Ford, PA1
Barnes, PJ1
Adcock, IM1
Chung, KF1
Flannigan, KL1
Agbor, TA1
Blackler, RW1
Kim, JJ1
Khan, WI1
Verdu, EF1
Ferraz, JG1
Wallace, JL1
Panza, E1
De Cicco, P1
Armogida, C1
Scognamiglio, G1
Gigantino, V1
Botti, G1
Germano, D1
Napolitano, M1
Bucci, M1
Cirino, G1
Ianaro, A1
Li, H2
Feng, SJ1
Zhang, GZ1
Wang, SX1
Yang, J1
Ochs, T1
Zhao, J2
Zhang, Q1
Du, S1
Chen, Y1
Liu, P1
Feng, X1
Zhang, C1
Tang, C1
Du, J1
Jin, H1
Sun, J1
Shen, X1
Li, Y1
Guo, Z1
Zhu, W1
Zuo, L1
Gu, L1
Gong, J1
Li, J1
Ji, L1
Li, L1
Qu, F1
Zhang, G1
Bai, X1
Pan, S1
Xue, D1
Wang, G1
Sun, B1
Huang, S1
Huang, P1
Liu, X1
Lin, Z1
Wang, J1
Xu, S1
Guo, L1
Leung, CK1
Zhong, Y1
Magierowski, M1
Magierowska, K1
Hubalewska-Mazgaj, M1
Sliwowski, Z1
Pajdo, R1
Ginter, G1
Kwiecien, S1
Brzozowski, T1
Givvimani, S1
Munjal, C1
Gargoum, R1
Sen, U1
Tyagi, N1
Vacek, JC1
Tyagi, SC1
Aminzadeh, MA1
Vaziri, ND1
Ahmad, FU1
Sattar, MA1
Rathore, HA1
Abdullah, MH1
Tan, S1
Abdullah, NA1
Johns, EJ1
Yamamoto, J1
Sato, W1
Kosugi, T1
Yamamoto, T1
Kimura, T1
Taniguchi, S1
Kojima, H1
Maruyama, S1
Imai, E1
Matsuo, S1
Yuzawa, Y1
Niki, I1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Plasma Measurement of Hydrogen Sulfide, Nitric Oxide and Stress Hyperglycemia in Acute Myocardial Infarction[NCT03829605]50 participants (Anticipated)Observational2019-02-15Not yet recruiting
Enhancement of In-vitro GC Function in Patients With COPD. A Randomised, Double Blind, Placebo Controlled, Parallel-group Study to Investigate the Effect of Theophylline and Fluticasone on Induced Sputum Cells Obtained Form COPD Patients[NCT00241631]Phase 249 participants (Actual)Interventional2006-04-30Completed
Intermittent Fasting as a Primary Means for Improving Quality of Life for Acute and Chronic Pancreatitis[NCT04760847]64 participants (Anticipated)Interventional2023-12-07Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Interleukin 8 (IL8)

Interleukin 8 (IL8) assessed from sputum (NCT00241631)
Timeframe: 10 weeks

Interventionng/mL (Mean)
Placebo33.3
Steroid28.3

Sputum Inflammatory Cell Counts

Supernatant collect, cell pellets count on slides (NCT00241631)
Timeframe: 10 weeks

Interventionmillions cells/ ml (Mean)
Placebo5.42
Steroid3.89

Total Sputum Eosinophils

Total eosinophils cells assessed from sputum (NCT00241631)
Timeframe: 10 weeks

Interventionmillions cells/ml (Mean)
Placebo0.132
Steroid0.053

Reviews

2 reviews available for hydrogen sulfide and Disease Exacerbation

ArticleYear
Involvement of hydrogen sulfide in the progression of renal fibrosis.
    Chinese medical journal, 2019, Dec-05, Volume: 132, Issue:23

    Topics: Animals; Disease Progression; Fibrosis; Humans; Hydrogen Sulfide; Kidney

2019
Therapeutic Potential to Modify the Mucus Barrier in Inflammatory Bowel Disease.
    Nutrients, 2016, Jan-14, Volume: 8, Issue:1

    Topics: Animals; Colitis, Ulcerative; Crohn Disease; Disease Progression; Fatty Acid Synthases; Fatty Acids,

2016

Trials

1 trial available for hydrogen sulfide and Disease Exacerbation

ArticleYear
Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD.
    The European respiratory journal, 2014, Volume: 43, Issue:5

    Topics: Adrenal Cortex Hormones; Biomarkers; Bronchodilator Agents; Disease Progression; Forced Expiratory V

2014

Other Studies

26 other studies available for hydrogen sulfide and Disease Exacerbation

ArticleYear
Sub-1.4 cm
    Nature, 2023, Volume: 620, Issue:7973

    Topics: Administration, Oral; Animals; Bacteria; Biomarkers; Biosensing Techniques; Body Size; Capsules; Dis

2023
Mental retardation in Down syndrome: Two ways to treat.
    Medical hypotheses, 2019, Volume: 131

    Topics: Aminooxyacetic Acid; Animals; Benserazide; Brain; Chromosomes, Human, Pair 21; Cobamides; Cystathion

2019
Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis.
    EMBO reports, 2019, 10-04, Volume: 20, Issue:10

    Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Cystathi

2019
The role of hydrogen sulfide in the progression of chronic obstructive pulmonary disease in patients with non-alcoholic steatohepatitis
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2019, Oct-31, Volume: 72, Issue:10

    Topics: Adult; Disease Progression; Humans; Hydrogen Sulfide; Middle Aged; Non-alcoholic Fatty Liver Disease

2019
Selenium-binding protein 1 alters energy metabolism in prostate cancer cells.
    The Prostate, 2020, Volume: 80, Issue:12

    Topics: AMP-Activated Protein Kinase Kinases; Cell Line, Tumor; Cell Transformation, Viral; Disease Progress

2020
Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function.
    Science (New York, N.Y.), 2020, 09-18, Volume: 369, Issue:6510

    Topics: Animals; Diet; Dietary Proteins; Disease Models, Animal; Disease Progression; Escherichia coli; Gast

2020
Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress.
    Toxicology and applied pharmacology, 2021, 07-15, Volume: 423

    Topics: Animals; Disease Progression; Endoplasmic Reticulum Stress; Gasotransmitters; Hydrogen Sulfide; KATP

2021
Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis.
    Free radical biology & medicine, 2017, Volume: 112

    Topics: Actins; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Progression; Epithe

2017
Sputum-to-serum hydrogen sulphide ratio as a novel biomarker of predicting future risks of asthma exacerbation.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2018, Volume: 48, Issue:9

    Topics: Adult; Aged; Asthma; Biomarkers; Cross-Sectional Studies; Cytokines; Disease Progression; Female; Hu

2018
Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction.
    American journal of nephrology, 2018, Volume: 47, Issue:5

    Topics: Adult; Aged; Biomarkers; Disease Progression; Echocardiography; Female; Glomerular Filtration Rate;

2018
Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.
    Circulation, 2019, 01-02, Volume: 139, Issue:1

    Topics: Aged; Aged, 80 and over; Animals; Atherosclerosis; Carotid Arteries; Carotid Artery Diseases; Cathep

2019
Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis.
    Canadian journal of physiology and pharmacology, 2019, Volume: 97, Issue:1

    Topics: Animals; Disease Progression; Gasotransmitters; Hydrogen Sulfide; Injections, Intra-Articular; Male;

2019
Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms.
    Neurobiology of learning and memory, 2013, Volume: 104

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Disease Progression; Hipp

2013
Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction.
    Biochimica et biophysica acta, 2013, Volume: 1832, Issue:12

    Topics: Animals; Blood Pressure; Blotting, Western; Cystathionine beta-Synthase; Cystathionine gamma-Lyase;

2013
Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:1

    Topics: Animals; Choline Deficiency; Cytochrome P-450 CYP2E1; Disease Models, Animal; Disease Progression; F

2014
Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Sep-16, Volume: 111, Issue:37

    Topics: Animals; Colitis; Colon; Dextran Sulfate; Diet; Disease Progression; Humans; Hydrogen Sulfide; Hyper

2014
Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression.
    Pigment cell & melanoma research, 2015, Volume: 28, Issue:1

    Topics: Allyl Compounds; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; C

2015
Correlation of lower concentrations of hydrogen sulfide with atherosclerosis in chronic hemodialysis patients with diabetic nephropathy.
    Blood purification, 2014, Volume: 38, Issue:3-4

    Topics: Adult; Aged; Carotid Artery Diseases; Carotid Artery, Common; Carotid Intima-Media Thickness; Diabet

2014
Erythrocytic hydrogen sulfide production is increased in children with vasovagal syncope.
    The Journal of pediatrics, 2015, Volume: 166, Issue:4

    Topics: Adolescent; Biomarkers; Child; Child, Preschool; Disease Progression; Electrocardiography; Erythrocy

2015
Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK/mTOR pathway.
    Journal of cellular and molecular medicine, 2016, Volume: 20, Issue:12

    Topics: Alkynes; AMP-Activated Protein Kinases; Animals; Autophagy; Cell Line; Disease Progression; Glycine;

2016
Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model.
    Neuroscience, 2017, 01-26, Volume: 341

    Topics: Animals; Cell Survival; Cells, Cultured; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Dis

2017
Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations.
    Molecules (Basel, Switzerland), 2017, Feb-15, Volume: 22, Issue:2

    Topics: Animals; Biomarkers; Disease Models, Animal; Disease Progression; Gastric Mucosa; Gene Expression; H

2017
Hydrogen sulfide mitigates transition from compensatory hypertrophy to heart failure.
    Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:4

    Topics: Analysis of Variance; Animals; Blotting, Western; Cardiomegaly; Disease Progression; Echocardiograph

2011
Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:2

    Topics: Animals; Biomarkers; Blood Pressure Determination; Blotting, Western; Brain; Disease Models, Animal;

2012
Exogenous hydrogen sulfide (H2S) reduces blood pressure and prevents the progression of diabetic nephropathy in spontaneously hypertensive rats.
    Renal failure, 2012, Volume: 34, Issue:2

    Topics: Animals; Blood Pressure; Diabetic Nephropathies; Disease Progression; Hydrogen Sulfide; Hypertension

2012
Distribution of hydrogen sulfide (H₂S)-producing enzymes and the roles of the H₂S donor sodium hydrosulfide in diabetic nephropathy.
    Clinical and experimental nephrology, 2013, Volume: 17, Issue:1

    Topics: Animals; Calmodulin; Capillaries; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diabetes M

2013