hydrogen sulfide has been researched along with Disease Exacerbation in 29 studies
Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.
Excerpt | Relevance | Reference |
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"Literature was collected from PubMed until February 2019, using the search terms including "Hydrogen sulfide," "Chronic kidney disease," "Renal interstitial fibrosis," "Kidney disease," "Inflammation factor," "Oxidative stress," "Epithelial-to-mesenchymal transition," "H2S donor," "Hypertensive kidney dysfunction," "Myofibroblasts," "Vascular remodeling," "transforming growth factor (TGF)-beta/Smads signaling," and "Sulfate potassium channels." | 9.01 | Involvement of hydrogen sulfide in the progression of renal fibrosis. ( Huang, L; Peng, ZZ; Qin, J; Tang, WB; Tao, LJ; Tu, JK; Wang, W; Wang, Y; Xiao, XC; Xie, YY; Xing, QQ; Xu, H; Yuan, QJ; Yuan, XN, 2019) |
"Glaucoma is an irreversible and blinding neurodegenerative disease of the eye, and is characterized by progressive loss of retinal ganglion cells (RGCs)." | 5.46 | Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model. ( Guo, L; Huang, P; Huang, S; Leung, CK; Lin, Z; Liu, X; Wang, J; Xu, S; Zhong, Y, 2017) |
"Hydrogen sulfide (H2S) is a gaseous mediator that promotes tissue repair and resolution of inflammation." | 5.40 | Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis. ( Agbor, TA; Blackler, RW; Ferraz, JG; Flannigan, KL; Khan, WI; Kim, JJ; Verdu, EF; Wallace, JL, 2014) |
"Literature was collected from PubMed until February 2019, using the search terms including "Hydrogen sulfide," "Chronic kidney disease," "Renal interstitial fibrosis," "Kidney disease," "Inflammation factor," "Oxidative stress," "Epithelial-to-mesenchymal transition," "H2S donor," "Hypertensive kidney dysfunction," "Myofibroblasts," "Vascular remodeling," "transforming growth factor (TGF)-beta/Smads signaling," and "Sulfate potassium channels." | 5.01 | Involvement of hydrogen sulfide in the progression of renal fibrosis. ( Huang, L; Peng, ZZ; Qin, J; Tang, WB; Tao, LJ; Tu, JK; Wang, W; Wang, Y; Xiao, XC; Xie, YY; Xing, QQ; Xu, H; Yuan, QJ; Yuan, XN, 2019) |
"Transient molecules in the gastrointestinal tract such as nitric oxide and hydrogen sulfide are key signals and mediators of inflammation." | 4.31 | Sub-1.4 cm ( Ahn, J; Chandrakasan, AP; Fabian, N; Hayward, A; Inda-Webb, ME; Ishida, K; Jenkins, J; Jimenez, M; Kuosmanen, J; Lai, Y; Liu, Q; Lu, TK; Madani, W; McNally, R; Mimee, M; Nadeau, P; Phan, NV; Riaz, A; Steiger, C; Traverso, G; Wentworth, A; Wong, K; Yazicigil, RT; Zirtiloglu, T, 2023) |
" The potential for HNF4α to regulate SBP1 expression was supported by data indicating that HNF4α inhibition resulted in a dose-response increase in the levels of SBP1 messenger RNA and protein, identifying HNF4α as a novel negative regulator of SBP1 expression in prostate cancer cells." | 1.56 | Selenium-binding protein 1 alters energy metabolism in prostate cancer cells. ( Diamond, AM; Elhodaky, M; Hong, LK; Kadkol, S, 2020) |
"Prenatal treatment of Down syndrome fetuses is also suggested." | 1.51 | Mental retardation in Down syndrome: Two ways to treat. ( Kamoun, PP, 2019) |
"Patients with chronic obstructive pulmonary disease and non-alcoholic steatohepatitis, which developed against the background of obesity, are characterized by a significant increase in the synthesis of collagen and glycoproteins, which was accompanied by an ineffective resorption of newly formed collagen against the background of substantial activation of proteinase inhibitors (α2-MG), accompanied by the hyperproduction of nitrogen monoxide, endothelin-1, hyperlipidemia, deficiency of hydrogen sulfide liberation." | 1.51 | The role of hydrogen sulfide in the progression of chronic obstructive pulmonary disease in patients with non-alcoholic steatohepatitis ( Dudka, IV; Dudka, TV; Hryniuk, OY; Khukhlina, OS; Kovalenko, SV; Mandry, OY, 2019) |
"Glaucoma is an irreversible and blinding neurodegenerative disease of the eye, and is characterized by progressive loss of retinal ganglion cells (RGCs)." | 1.46 | Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model. ( Guo, L; Huang, P; Huang, S; Leung, CK; Lin, Z; Liu, X; Wang, J; Xu, S; Zhong, Y, 2017) |
"Hydrogen sulfide (H₂S) is an endogenous mediator, synthesized from l-cysteine by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) or 3-mercaptopyruvate sulfurtransferase (3-MST)." | 1.46 | Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations. ( Brzozowski, T; Ginter, G; Hubalewska-Mazgaj, M; Kwiecien, S; Magierowska, K; Magierowski, M; Pajdo, R; Sliwowski, Z, 2017) |
"Hydrogen sulfide (H2S) is a gaseous mediator that promotes tissue repair and resolution of inflammation." | 1.40 | Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis. ( Agbor, TA; Blackler, RW; Ferraz, JG; Flannigan, KL; Khan, WI; Kim, JJ; Verdu, EF; Wallace, JL, 2014) |
"Hydrogen sulfide (H(2)S) has recently been found to play beneficial roles in ameliorating several diseases, including hypertension, atherosclerosis and cardiac/renal ischemia-reperfusion injuries." | 1.39 | Distribution of hydrogen sulfide (H₂S)-producing enzymes and the roles of the H₂S donor sodium hydrosulfide in diabetic nephropathy. ( Imai, E; Kimura, T; Kojima, H; Kosugi, T; Maruyama, S; Matsuo, S; Niki, I; Sato, W; Taniguchi, S; Yamamoto, J; Yamamoto, T; Yuzawa, Y, 2013) |
"Hydrogen sulfide (H(2)S) is an endogenous signaling gas, which possesses potent anti-oxidant, anti-inflammatory, anti-hypertensive and other regulatory functions." | 1.38 | Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease. ( Aminzadeh, MA; Vaziri, ND, 2012) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 25 (86.21) | 24.3611 |
2020's | 4 (13.79) | 2.80 |
Authors | Studies |
---|---|
Inda-Webb, ME | 1 |
Jimenez, M | 1 |
Liu, Q | 1 |
Phan, NV | 1 |
Ahn, J | 1 |
Steiger, C | 1 |
Wentworth, A | 1 |
Riaz, A | 1 |
Zirtiloglu, T | 1 |
Wong, K | 1 |
Ishida, K | 1 |
Fabian, N | 1 |
Jenkins, J | 1 |
Kuosmanen, J | 1 |
Madani, W | 1 |
McNally, R | 1 |
Lai, Y | 1 |
Hayward, A | 1 |
Mimee, M | 1 |
Nadeau, P | 1 |
Chandrakasan, AP | 1 |
Traverso, G | 1 |
Yazicigil, RT | 1 |
Lu, TK | 1 |
Kamoun, PP | 1 |
Wang, YH | 1 |
Huang, JT | 1 |
Chen, WL | 1 |
Wang, RH | 1 |
Kao, MC | 1 |
Pan, YR | 1 |
Chan, SH | 1 |
Tsai, KW | 1 |
Kung, HJ | 1 |
Lin, KT | 1 |
Wang, LH | 1 |
Wang, Y | 3 |
Xing, QQ | 1 |
Tu, JK | 1 |
Tang, WB | 1 |
Yuan, XN | 1 |
Xie, YY | 1 |
Wang, W | 1 |
Peng, ZZ | 1 |
Huang, L | 1 |
Xu, H | 1 |
Qin, J | 1 |
Xiao, XC | 1 |
Tao, LJ | 1 |
Yuan, QJ | 1 |
Khukhlina, OS | 1 |
Hryniuk, OY | 1 |
Dudka, IV | 1 |
Kovalenko, SV | 1 |
Dudka, TV | 1 |
Mandry, OY | 1 |
Elhodaky, M | 1 |
Hong, LK | 1 |
Kadkol, S | 1 |
Diamond, AM | 1 |
Lobel, L | 1 |
Cao, YG | 1 |
Fenn, K | 1 |
Glickman, JN | 1 |
Garrett, WS | 1 |
Minaei, A | 1 |
Sarookhani, MR | 1 |
Haghdoost-Yazdi, H | 1 |
Rajaei, F | 1 |
Han, SJ | 2 |
Noh, MR | 1 |
Jung, JM | 1 |
Ishii, I | 1 |
Yoo, J | 1 |
Kim, JI | 2 |
Park, KM | 2 |
Suzuki, Y | 1 |
Saito, J | 1 |
Kikuchi, M | 1 |
Uematsu, M | 1 |
Fukuhara, A | 1 |
Sato, S | 1 |
Munakata, M | 1 |
Kuang, Q | 1 |
Xue, N | 1 |
Chen, J | 1 |
Shen, Z | 1 |
Cui, X | 1 |
Fang, Y | 1 |
Ding, X | 1 |
Bibli, SI | 1 |
Hu, J | 1 |
Sigala, F | 1 |
Wittig, I | 1 |
Heidler, J | 1 |
Zukunft, S | 1 |
Tsilimigras, DI | 1 |
Randriamboavonjy, V | 1 |
Wittig, J | 1 |
Kojonazarov, B | 1 |
Schürmann, C | 1 |
Siragusa, M | 1 |
Siuda, D | 1 |
Luck, B | 1 |
Abdel Malik, R | 1 |
Filis, KA | 1 |
Zografos, G | 1 |
Chen, C | 1 |
Wang, DW | 1 |
Pfeilschifter, J | 1 |
Brandes, RP | 1 |
Szabo, C | 1 |
Papapetropoulos, A | 2 |
Fleming, I | 1 |
Aytekin, K | 1 |
Erhan, SŞ | 1 |
Erişgin, Z | 1 |
Esenyel, CZ | 1 |
Takır, S | 1 |
Giuliani, D | 1 |
Ottani, A | 1 |
Zaffe, D | 1 |
Galantucci, M | 1 |
Strinati, F | 1 |
Lodi, R | 1 |
Guarini, S | 1 |
Jung, KJ | 1 |
Jang, HS | 1 |
Park, JW | 1 |
Luo, ZL | 1 |
Tang, LJ | 1 |
Wang, T | 1 |
Dai, RW | 1 |
Ren, JD | 1 |
Cheng, L | 1 |
Xiang, K | 1 |
Tian, FZ | 1 |
Kirkham, PA | 1 |
Whiteman, M | 1 |
Winyard, PG | 1 |
Caramori, G | 1 |
Gordon, F | 1 |
Ford, PA | 1 |
Barnes, PJ | 1 |
Adcock, IM | 1 |
Chung, KF | 1 |
Flannigan, KL | 1 |
Agbor, TA | 1 |
Blackler, RW | 1 |
Kim, JJ | 1 |
Khan, WI | 1 |
Verdu, EF | 1 |
Ferraz, JG | 1 |
Wallace, JL | 1 |
Panza, E | 1 |
De Cicco, P | 1 |
Armogida, C | 1 |
Scognamiglio, G | 1 |
Gigantino, V | 1 |
Botti, G | 1 |
Germano, D | 1 |
Napolitano, M | 1 |
Bucci, M | 1 |
Cirino, G | 1 |
Ianaro, A | 1 |
Li, H | 2 |
Feng, SJ | 1 |
Zhang, GZ | 1 |
Wang, SX | 1 |
Yang, J | 1 |
Ochs, T | 1 |
Zhao, J | 2 |
Zhang, Q | 1 |
Du, S | 1 |
Chen, Y | 1 |
Liu, P | 1 |
Feng, X | 1 |
Zhang, C | 1 |
Tang, C | 1 |
Du, J | 1 |
Jin, H | 1 |
Sun, J | 1 |
Shen, X | 1 |
Li, Y | 1 |
Guo, Z | 1 |
Zhu, W | 1 |
Zuo, L | 1 |
Gu, L | 1 |
Gong, J | 1 |
Li, J | 1 |
Ji, L | 1 |
Li, L | 1 |
Qu, F | 1 |
Zhang, G | 1 |
Bai, X | 1 |
Pan, S | 1 |
Xue, D | 1 |
Wang, G | 1 |
Sun, B | 1 |
Huang, S | 1 |
Huang, P | 1 |
Liu, X | 1 |
Lin, Z | 1 |
Wang, J | 1 |
Xu, S | 1 |
Guo, L | 1 |
Leung, CK | 1 |
Zhong, Y | 1 |
Magierowski, M | 1 |
Magierowska, K | 1 |
Hubalewska-Mazgaj, M | 1 |
Sliwowski, Z | 1 |
Pajdo, R | 1 |
Ginter, G | 1 |
Kwiecien, S | 1 |
Brzozowski, T | 1 |
Givvimani, S | 1 |
Munjal, C | 1 |
Gargoum, R | 1 |
Sen, U | 1 |
Tyagi, N | 1 |
Vacek, JC | 1 |
Tyagi, SC | 1 |
Aminzadeh, MA | 1 |
Vaziri, ND | 1 |
Ahmad, FU | 1 |
Sattar, MA | 1 |
Rathore, HA | 1 |
Abdullah, MH | 1 |
Tan, S | 1 |
Abdullah, NA | 1 |
Johns, EJ | 1 |
Yamamoto, J | 1 |
Sato, W | 1 |
Kosugi, T | 1 |
Yamamoto, T | 1 |
Kimura, T | 1 |
Taniguchi, S | 1 |
Kojima, H | 1 |
Maruyama, S | 1 |
Imai, E | 1 |
Matsuo, S | 1 |
Yuzawa, Y | 1 |
Niki, I | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Plasma Measurement of Hydrogen Sulfide, Nitric Oxide and Stress Hyperglycemia in Acute Myocardial Infarction[NCT03829605] | 50 participants (Anticipated) | Observational | 2019-02-15 | Not yet recruiting | |||
Enhancement of In-vitro GC Function in Patients With COPD. A Randomised, Double Blind, Placebo Controlled, Parallel-group Study to Investigate the Effect of Theophylline and Fluticasone on Induced Sputum Cells Obtained Form COPD Patients[NCT00241631] | Phase 2 | 49 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
Intermittent Fasting as a Primary Means for Improving Quality of Life for Acute and Chronic Pancreatitis[NCT04760847] | 64 participants (Anticipated) | Interventional | 2023-12-07 | Not yet recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Interleukin 8 (IL8) assessed from sputum (NCT00241631)
Timeframe: 10 weeks
Intervention | ng/mL (Mean) |
---|---|
Placebo | 33.3 |
Steroid | 28.3 |
Supernatant collect, cell pellets count on slides (NCT00241631)
Timeframe: 10 weeks
Intervention | millions cells/ ml (Mean) |
---|---|
Placebo | 5.42 |
Steroid | 3.89 |
Total eosinophils cells assessed from sputum (NCT00241631)
Timeframe: 10 weeks
Intervention | millions cells/ml (Mean) |
---|---|
Placebo | 0.132 |
Steroid | 0.053 |
2 reviews available for hydrogen sulfide and Disease Exacerbation
Article | Year |
---|---|
Involvement of hydrogen sulfide in the progression of renal fibrosis.
Topics: Animals; Disease Progression; Fibrosis; Humans; Hydrogen Sulfide; Kidney | 2019 |
Therapeutic Potential to Modify the Mucus Barrier in Inflammatory Bowel Disease.
Topics: Animals; Colitis, Ulcerative; Crohn Disease; Disease Progression; Fatty Acid Synthases; Fatty Acids, | 2016 |
1 trial available for hydrogen sulfide and Disease Exacerbation
Article | Year |
---|---|
Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD.
Topics: Adrenal Cortex Hormones; Biomarkers; Bronchodilator Agents; Disease Progression; Forced Expiratory V | 2014 |
26 other studies available for hydrogen sulfide and Disease Exacerbation
Article | Year |
---|---|
Sub-1.4 cm
Topics: Administration, Oral; Animals; Bacteria; Biomarkers; Biosensing Techniques; Body Size; Capsules; Dis | 2023 |
Mental retardation in Down syndrome: Two ways to treat.
Topics: Aminooxyacetic Acid; Animals; Benserazide; Brain; Chromosomes, Human, Pair 21; Cobamides; Cystathion | 2019 |
Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Cystathi | 2019 |
The role of hydrogen sulfide in the progression of chronic obstructive pulmonary disease in patients with non-alcoholic steatohepatitis
Topics: Adult; Disease Progression; Humans; Hydrogen Sulfide; Middle Aged; Non-alcoholic Fatty Liver Disease | 2019 |
Selenium-binding protein 1 alters energy metabolism in prostate cancer cells.
Topics: AMP-Activated Protein Kinase Kinases; Cell Line, Tumor; Cell Transformation, Viral; Disease Progress | 2020 |
Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function.
Topics: Animals; Diet; Dietary Proteins; Disease Models, Animal; Disease Progression; Escherichia coli; Gast | 2020 |
Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress.
Topics: Animals; Disease Progression; Endoplasmic Reticulum Stress; Gasotransmitters; Hydrogen Sulfide; KATP | 2021 |
Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis.
Topics: Actins; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Progression; Epithe | 2017 |
Sputum-to-serum hydrogen sulphide ratio as a novel biomarker of predicting future risks of asthma exacerbation.
Topics: Adult; Aged; Asthma; Biomarkers; Cross-Sectional Studies; Cytokines; Disease Progression; Female; Hu | 2018 |
Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction.
Topics: Adult; Aged; Biomarkers; Disease Progression; Echocardiography; Female; Glomerular Filtration Rate; | 2018 |
Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.
Topics: Aged; Aged, 80 and over; Animals; Atherosclerosis; Carotid Arteries; Carotid Artery Diseases; Cathep | 2019 |
Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis.
Topics: Animals; Disease Progression; Gasotransmitters; Hydrogen Sulfide; Injections, Intra-Articular; Male; | 2019 |
Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Disease Progression; Hipp | 2013 |
Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction.
Topics: Animals; Blood Pressure; Blotting, Western; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; | 2013 |
Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats.
Topics: Animals; Choline Deficiency; Cytochrome P-450 CYP2E1; Disease Models, Animal; Disease Progression; F | 2014 |
Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Diet; Disease Progression; Humans; Hydrogen Sulfide; Hyper | 2014 |
Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression.
Topics: Allyl Compounds; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; C | 2015 |
Correlation of lower concentrations of hydrogen sulfide with atherosclerosis in chronic hemodialysis patients with diabetic nephropathy.
Topics: Adult; Aged; Carotid Artery Diseases; Carotid Artery, Common; Carotid Intima-Media Thickness; Diabet | 2014 |
Erythrocytic hydrogen sulfide production is increased in children with vasovagal syncope.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Disease Progression; Electrocardiography; Erythrocy | 2015 |
Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK/mTOR pathway.
Topics: Alkynes; AMP-Activated Protein Kinases; Animals; Autophagy; Cell Line; Disease Progression; Glycine; | 2016 |
Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model.
Topics: Animals; Cell Survival; Cells, Cultured; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Dis | 2017 |
Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Progression; Gastric Mucosa; Gene Expression; H | 2017 |
Hydrogen sulfide mitigates transition from compensatory hypertrophy to heart failure.
Topics: Analysis of Variance; Animals; Blotting, Western; Cardiomegaly; Disease Progression; Echocardiograph | 2011 |
Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease.
Topics: Animals; Biomarkers; Blood Pressure Determination; Blotting, Western; Brain; Disease Models, Animal; | 2012 |
Exogenous hydrogen sulfide (H2S) reduces blood pressure and prevents the progression of diabetic nephropathy in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Diabetic Nephropathies; Disease Progression; Hydrogen Sulfide; Hypertension | 2012 |
Distribution of hydrogen sulfide (H₂S)-producing enzymes and the roles of the H₂S donor sodium hydrosulfide in diabetic nephropathy.
Topics: Animals; Calmodulin; Capillaries; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diabetes M | 2013 |