Page last updated: 2024-10-17

hydrogen sulfide and Diabetes Mellitus

hydrogen sulfide has been researched along with Diabetes Mellitus in 32 studies

Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

ExcerptRelevanceReference
"Sensitive detection of acetone and hydrogen sulfide levels in exhaled human breath, serving as breath markers for some diseases such as diabetes and halitosis, may offer useful information for early diagnosis of these diseases."7.80Selective detection of acetone and hydrogen sulfide for the diagnosis of diabetes and halitosis using SnO(2) nanofibers functionalized with reduced graphene oxide nanosheets. ( Choi, SJ; Jang, BH; Kim, ID; Lee, SJ; Min, BK; Rothschild, A, 2014)
"Hydrogen sulfide (H2S)has emerged as the third gasotransmitter following the nitric oxide and carbon monoxide in the body, and plays an important role in both physiology and pathophysiology."6.58[Research Advances in Hydrogen Sulfide and Diabetes Mellitus as Well as Diabetic Complications]. ( Gu, Y; Ji, Y; Meng, GL; Xie, LP, 2018)
"Hydrogen sulfide (H2S) has been shown to have powerful antioxidative and anti-inflammatory properties that can regulate multiple cardiovascular functions."5.43Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation. ( Ferro, A; Gu, Y; Han, Y; Huang, Z; Ji, Y; Liu, G; Ma, Y; Meng, G; Moore, PK; Wang, H; Wang, W; Wang, X; Wang, Y; Wen, M; Xie, L; Yu, Y; Zhang, Z; Zhao, S, 2016)
"DNA-based sensors can detect disease biomarkers, including acetone and ethanol for diabetes and H2S for cardiovascular diseases."3.83Ranking of Molecular Biomarker Interaction with Targeted DNA Nucleobases via Full Atomistic Molecular Dynamics. ( Cranford, SW; Wang, ML; Zhang, W, 2016)
"Sensitive detection of acetone and hydrogen sulfide levels in exhaled human breath, serving as breath markers for some diseases such as diabetes and halitosis, may offer useful information for early diagnosis of these diseases."3.80Selective detection of acetone and hydrogen sulfide for the diagnosis of diabetes and halitosis using SnO(2) nanofibers functionalized with reduced graphene oxide nanosheets. ( Choi, SJ; Jang, BH; Kim, ID; Lee, SJ; Min, BK; Rothschild, A, 2014)
" Here, we report ultrafast as well as highly sensitive bumpy WO3 hemitube nanostructure assisted by O2 plasma surface modification with functionalization of graphene-based material for the detection of acetone (CH3COCH3) and hydrogen sulfide (H2S) which are biomarkers for the diagnosis of diabetes and halitosis, respectively."3.80Fast responding exhaled-breath sensors using WO3 hemitubes functionalized by graphene-based electronic sensitizers for diagnosis of diseases. ( Choi, SJ; Demadrille, R; Fuchs, F; Grévin, B; Jang, BH; Kim, ID; Lee, JH; Lee, SJ; Tuller, HL, 2014)
"Hydrogen sulfide (H2S)has emerged as the third gasotransmitter following the nitric oxide and carbon monoxide in the body, and plays an important role in both physiology and pathophysiology."2.58[Research Advances in Hydrogen Sulfide and Diabetes Mellitus as Well as Diabetic Complications]. ( Gu, Y; Ji, Y; Meng, GL; Xie, LP, 2018)
"Hydrogen sulfide (H2S) is a biologically active gas that is synthesized naturally by three enzymes, cystathionine γ-lyase (CSE), cystathionine β-synthetase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST)."2.52H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects. ( Huang, CW; Moore, PK, 2015)
"Hydrogen sulfide (H2S) is a gasotransmitter that regulates numerous physiological and pathophysiological processes in our body."2.50Hydrogen sulfide and the liver. ( Cao, W; Mani, S; Wang, R; Wu, L, 2014)
" In patients with diabetes, a lower bioavailability of the different gasotransmitters is observed when compared with healthy individuals."1.43Gasotransmitters in Vascular Complications of Diabetes. ( Greffrath, W; Hammes, HP; Hillebrands, JL; van den Born, JC; van Goor, H, 2016)
"Hydrogen sulfide (H2S) has been shown to have powerful antioxidative and anti-inflammatory properties that can regulate multiple cardiovascular functions."1.43Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation. ( Ferro, A; Gu, Y; Han, Y; Huang, Z; Ji, Y; Liu, G; Ma, Y; Meng, G; Moore, PK; Wang, H; Wang, W; Wang, X; Wang, Y; Wen, M; Xie, L; Yu, Y; Zhang, Z; Zhao, S, 2016)
"Hydrogen sulfide (H(2)S) has recently been found to play beneficial roles in ameliorating several diseases, including hypertension, atherosclerosis and cardiac/renal ischemia-reperfusion injuries."1.39Distribution of hydrogen sulfide (H₂S)-producing enzymes and the roles of the H₂S donor sodium hydrosulfide in diabetic nephropathy. ( Imai, E; Kimura, T; Kojima, H; Kosugi, T; Maruyama, S; Matsuo, S; Niki, I; Sato, W; Taniguchi, S; Yamamoto, J; Yamamoto, T; Yuzawa, Y, 2013)
"Hydrogen sulfide (H(2)S) is an important signaling molecule in various mammalian cells and tissues."1.37Significance of hydrogen sulfide production in the pancreatic β-cell. ( Niki, I; Taniguchi, S, 2011)
"Hydrogen sulfide (H(2)S) has been traditionally known for its toxic effects on living organisms."1.35Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats. ( Cao, K; Duridanova, D; Jia, X; Wang, R; Wu, L; Yang, G; Yang, W, 2009)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (9.38)29.6817
2010's19 (59.38)24.3611
2020's10 (31.25)2.80

Authors

AuthorsStudies
Carbone, F1
Montecucco, F1
Zhao, H1
Liu, H3
Yang, Y1
Lan, T1
Wang, H4
Wu, D1
Inada, R1
Mendoza, HY1
Tanaka, T1
Horie, T1
Satomi, T1
Sun, HJ1
Xiong, SP1
Wang, ZC1
Nie, XW1
Bian, JS1
Ge, Y1
Rong, F1
Lu, Y1
Wang, Z1
Liu, J1
Xu, F1
Chen, J1
Li, W1
Wang, Y2
Bushell, CJ1
Forgan, LG1
Aston-Mourney, K1
Connor, T1
McGee, SL1
McNeill, BA1
Liu, X1
Han, X1
Shang, Y1
Wang, L1
Shen, J1
Yuan, J1
Kang, SC1
Sohn, EH1
Lee, SR1
Shi, X1
Qiu, M1
Lv, S2
Zheng, H1
Niu, B1
Sandu, RE1
Dumbrava, D1
Surugiu, R1
Glavan, DG1
Gresita, A1
Petcu, EB1
Kashfi, K1
Gu, Y2
Xie, LP1
Meng, GL1
Ji, Y2
Okamoto, M1
Yamaoka, M1
Kimura, T2
Choi, SJ2
Jang, BH2
Lee, SJ2
Min, BK1
Rothschild, A1
Kim, ID2
Mani, S1
Cao, W1
Wu, L3
Wang, R3
Song, P1
Zou, MH1
Fuchs, F1
Demadrille, R1
Grévin, B1
Lee, JH1
Tuller, HL1
Coletta, C1
Módis, K1
Szczesny, B1
Brunyánszki, A1
Oláh, G1
Rios, EC1
Yanagi, K1
Ahmad, A1
Papapetropoulos, A1
Szabo, C2
Huang, CW1
Moore, PK2
Zhang, W1
Wang, ML1
Cranford, SW1
van den Born, JC1
Hammes, HP1
Greffrath, W1
van Goor, H1
Hillebrands, JL1
Xie, L1
Wen, M1
Zhao, S1
Wang, W1
Ma, Y1
Meng, G1
Han, Y1
Liu, G1
Wang, X1
Zhang, Z1
Yu, Y1
Ferro, A1
Huang, Z1
Gerő, D1
Torregrossa, R1
Perry, A1
Waters, A1
Le-Trionnaire, S1
Whatmore, JL1
Wood, M1
Whiteman, M1
Durante, W1
Yang, W2
Jia, X1
Yang, G2
Duridanova, D1
Cao, K1
Du, JB1
Tang, CS1
Taniguchi, S2
Niki, I3
Yamamoto, J1
Sato, W1
Kosugi, T1
Yamamoto, T1
Kojima, H1
Maruyama, S1
Imai, E1
Matsuo, S1
Yuzawa, Y1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease[NCT05457881]226 participants (Anticipated)Interventional2024-03-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for hydrogen sulfide and Diabetes Mellitus

ArticleYear
Hydrogen Sulfide Plays an Important Role by Regulating Endoplasmic Reticulum Stress in Diabetes-Related Diseases.
    International journal of molecular sciences, 2022, Jun-28, Volume: 23, Issue:13

    Topics: Diabetes Mellitus; Diabetic Cardiomyopathies; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; H

2022
Hydrogen Sulfide in Diabetic Complications Revisited: The State of the Art, Challenges, and Future Directions.
    Antioxidants & redox signaling, 2023, Volume: 38, Issue:1-3

    Topics: Diabetes Complications; Diabetes Mellitus; Humans; Hydrogen Sulfide; Liver

2023
Hydrogen Sulfide as a Potential Alternative for the Treatment of Myocardial Fibrosis.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Animals; Cardiomyopathies; Diabetes Mellitus; Fibrosis; Humans; Hydrogen Sulfide; Hypertension; Myoc

2020
Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome.
    International journal of biological sciences, 2020, Volume: 16, Issue:14

    Topics: Animals; Diabetes Mellitus; Humans; Hydrogen Sulfide; Inflammasomes; Macrophages; Neuroprotection; N

2020
Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related Diseases.
    International journal of molecular sciences, 2021, Jun-23, Volume: 22, Issue:13

    Topics: Animals; Autophagy; Depressive Disorder; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Cardiomy

2021
Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects.
    International journal of molecular sciences, 2017, Dec-29, Volume: 19, Issue:1

    Topics: Animals; Brain Ischemia; Caloric Restriction; Comorbidity; Diabetes Mellitus; Diet, High-Fat; Diseas

2017
[Research Advances in Hydrogen Sulfide and Diabetes Mellitus as Well as Diabetic Complications].
    Sheng li ke xue jin zhan [Progress in physiology], 2018, Jun-21, Volume: 48, Issue:1

    Topics: Carbon Monoxide; Diabetes Complications; Diabetes Mellitus; Humans; Hydrogen Sulfide; Nitric Oxide

2018
[Hydrogen sulfide and its effect on pancreatic beta-cells].
    Nihon rinsho. Japanese journal of clinical medicine, 2013, Volume: 71, Issue:1

    Topics: Animals; Cell Survival; Diabetes Mellitus; Humans; Hydrogen Sulfide; Insulin; Insulin-Secreting Cell

2013
Hydrogen sulfide and the liver.
    Nitric oxide : biology and chemistry, 2014, Sep-15, Volume: 41

    Topics: Animals; Diabetes Mellitus; Glucose; Humans; Hydrogen Sulfide; Lipid Metabolism; Liver; Liver Diseas

2014
H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects.
    Handbook of experimental pharmacology, 2015, Volume: 230

    Topics: Animals; Asthma; Atherosclerosis; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diabetes M

2015
Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications.
    Antioxidants & redox signaling, 2012, Jul-01, Volume: 17, Issue:1

    Topics: Animals; Diabetes Complications; Diabetes Mellitus; Humans; Hydrogen Sulfide

2012

Other Studies

21 other studies available for hydrogen sulfide and Diabetes Mellitus

ArticleYear
Hydrogen sulphide: Diabetic cardiomyopathy as the paradigm of its pleiotropic function.
    European journal of clinical investigation, 2022, Volume: 52, Issue:9

    Topics: Diabetes Mellitus; Diabetic Cardiomyopathies; Humans; Hydrogen Sulfide

2022
Preclinical study for the treatment of diabetes mellitus using β-like cells derived from human dental pulp stem cells.
    Regenerative medicine, 2022, Volume: 17, Issue:12

    Topics: Animals; Dental Pulp; Diabetes Mellitus; Humans; Hydrogen Sulfide; Insulins; Rats; Stem Cells

2022
Glucose Oxidase Driven Hydrogen Sulfide-Releasing Nanocascade for Diabetic Infection Treatment.
    Nano letters, 2023, 07-26, Volume: 23, Issue:14

    Topics: Diabetes Mellitus; Glucose; Glucose Oxidase; Humans; Hydrogen Peroxide; Hydrogen Sulfide; Nanopartic

2023
Characterisation of the hydrogen sulfide system in early diabetic kidney disease.
    Journal of molecular endocrinology, 2023, 11-01, Volume: 71, Issue:4

    Topics: Animals; Diabetes Mellitus; Diabetic Nephropathies; Endothelial Cells; Glucose; Hydrogen Sulfide; Ki

2023
Hydrogen sulfide releasing poly(γ-glutamic acid) biocomposite hydrogel with monitoring, antioxidant, and antibacterial properties for diabetic wound healing.
    International journal of biological macromolecules, 2023, Dec-31, Volume: 253, Issue:Pt 6

    Topics: Anthocyanins; Anti-Bacterial Agents; Antioxidants; Diabetes Mellitus; Glutamic Acid; Humans; Hydroge

2023
The role of hydrogen sulfide in health and disease.
    Biochemical pharmacology, 2018, Volume: 149

    Topics: Carbon Monoxide; Diabetes Mellitus; Gasotransmitters; Gastrointestinal Diseases; Gene Expression Reg

2018
Selective detection of acetone and hydrogen sulfide for the diagnosis of diabetes and halitosis using SnO(2) nanofibers functionalized with reduced graphene oxide nanosheets.
    ACS applied materials & interfaces, 2014, Feb-26, Volume: 6, Issue:4

    Topics: Acetone; Diabetes Mellitus; Graphite; Halitosis; Humans; Hydrogen Sulfide; Microscopy, Electron, Sca

2014
Redox regulation of endothelial cell fate.
    Cellular and molecular life sciences : CMLS, 2014, Volume: 71, Issue:17

    Topics: Animals; Apoptosis; Cardiovascular Diseases; Cell Cycle; Cell Movement; Cell Transdifferentiation; C

2014
Fast responding exhaled-breath sensors using WO3 hemitubes functionalized by graphene-based electronic sensitizers for diagnosis of diseases.
    ACS applied materials & interfaces, 2014, Jun-25, Volume: 6, Issue:12

    Topics: Acetone; Biosensing Techniques; Breath Tests; Diabetes Mellitus; Graphite; Halitosis; Humans; Hydrog

2014
Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
    Molecular medicine (Cambridge, Mass.), 2015, Feb-18, Volume: 21

    Topics: Animals; Cell Line; Cyclic GMP-Dependent Protein Kinases; Cysteine; Diabetes Mellitus; Disease Model

2015
Ranking of Molecular Biomarker Interaction with Targeted DNA Nucleobases via Full Atomistic Molecular Dynamics.
    Scientific reports, 2016, Jan-11, Volume: 6

    Topics: Acetone; Adenine; Biomarkers; Biosensing Techniques; Cardiovascular Diseases; Cytosine; Diabetes Mel

2016
Gasotransmitters in Vascular Complications of Diabetes.
    Diabetes, 2016, Volume: 65, Issue:2

    Topics: Biological Availability; Carbon Monoxide; Diabetes Mellitus; Diabetic Angiopathies; Gasotransmitters

2016
Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation.
    Diabetes, 2016, Volume: 65, Issue:10

    Topics: Active Transport, Cell Nucleus; Animals; Atherosclerosis; Diabetes Mellitus; Female; Glucose; Heme O

2016
The novel mitochondria-targeted hydrogen sulfide (H
    Pharmacological research, 2016, Volume: 113, Issue:Pt A

    Topics: Animals; Cell Line; Diabetes Mellitus; Electron Transport; Endothelial Cells; Endothelium, Vascular;

2016
Hydrogen Sulfide Therapy in Diabetes-Accelerated Atherosclerosis: A Whiff of Success.
    Diabetes, 2016, Volume: 65, Issue:10

    Topics: Atherosclerosis; Diabetes Mellitus; Humans; Hydrogen Sulfide

2016
Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats.
    Laboratory investigation; a journal of technical methods and pathology, 2009, Volume: 89, Issue:1

    Topics: Alkynes; Animals; Blood Glucose; Catalysis; Cystathionine gamma-Lyase; Diabetes Mellitus; Glycine; H

2009
[Study on hydrogen sulfide as a gasotransmitter: from bench to bedside].
    Zhonghua yi xue za zhi, 2008, Aug-19, Volume: 88, Issue:32

    Topics: Animals; Apoptosis; Cell Proliferation; Diabetes Mellitus; Gases; Humans; Hydrogen Sulfide; Hyperten

2008
Significance of hydrogen sulfide production in the pancreatic β-cell.
    Journal of pharmacological sciences, 2011, Volume: 116, Issue:1

    Topics: Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diabetes Mellitus; Humans; Hydrogen

2011
[Production of hydrogen sulfide and its protective role in the pancreatic B-cell].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2012, Volume: 139, Issue:1

    Topics: Animals; Diabetes Mellitus; Humans; Hydrogen Sulfide; Insulin; Insulin Secretion; Insulin-Secreting

2012
Distribution of hydrogen sulfide (H₂S)-producing enzymes and the roles of the H₂S donor sodium hydrosulfide in diabetic nephropathy.
    Clinical and experimental nephrology, 2013, Volume: 17, Issue:1

    Topics: Animals; Calmodulin; Capillaries; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diabetes M

2013
H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells.
    The Journal of biological chemistry, 2007, Jun-01, Volume: 282, Issue:22

    Topics: Adenoviridae; Air Pollutants; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Cystathionine gam

2007