Page last updated: 2024-10-17

hydrogen sulfide and Acute Kidney Injury

hydrogen sulfide has been researched along with Acute Kidney Injury in 27 studies

Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.

Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Research Excerpts

ExcerptRelevanceReference
"Atorvastatin significantly ameliorated renal dysfunction and morphological changes in CIAKI rats, as well as inflammation, apoptosis, and excessive oxidative stress."7.96Atorvastatin protects against contrast-induced acute kidney injury via upregulation of endogenous hydrogen sulfide. ( Jiaqiong, L; Ming, L; Xiaoyong, L; Xinxue, L; Xuexian, T; Yan, L; Yinglan, L; Yue, G; Zena, H, 2020)
" We investigated the role of hydrogen sulfide (H2S) in PHSML drainage in alleviating acute kidney injury (AKI) by administering D,L-propargylglycine (PPG) and sodium hydrosulfide hydrate (NaHS) to 12 specific pathogen-free male Wistar rats with PHSML drainage."7.81Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats. ( Han, B; Li, SG; Niu, CY; Zhang, LM; Zhao, ZG, 2015)
"Hydrogen sulfide (H2S) has been known as a novel gaseous signaling molecule."6.82Administration of hydrogen sulfide protects ischemia reperfusion-induced acute kidney injury by reducing the oxidative stress. ( Ahghari, P; Azizi, F; Kadkhodaee, M; Seifi, B, 2016)
"Hydrogen sulfide is a mediator of IRI and can ameliorate tissue injury in many organ systems."5.42Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats. ( Furness, P; Hosgood, SA; Hunter, JP; Nicholson, ML; Patel, M; Sayers, RD, 2015)
"Atorvastatin significantly ameliorated renal dysfunction and morphological changes in CIAKI rats, as well as inflammation, apoptosis, and excessive oxidative stress."3.96Atorvastatin protects against contrast-induced acute kidney injury via upregulation of endogenous hydrogen sulfide. ( Jiaqiong, L; Ming, L; Xiaoyong, L; Xinxue, L; Xuexian, T; Yan, L; Yinglan, L; Yue, G; Zena, H, 2020)
" We investigated the role of hydrogen sulfide (H2S) in PHSML drainage in alleviating acute kidney injury (AKI) by administering D,L-propargylglycine (PPG) and sodium hydrosulfide hydrate (NaHS) to 12 specific pathogen-free male Wistar rats with PHSML drainage."3.81Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats. ( Han, B; Li, SG; Niu, CY; Zhang, LM; Zhao, ZG, 2015)
"Hydrogen sulfide (H2S) has been known as a novel gaseous signaling molecule."2.82Administration of hydrogen sulfide protects ischemia reperfusion-induced acute kidney injury by reducing the oxidative stress. ( Ahghari, P; Azizi, F; Kadkhodaee, M; Seifi, B, 2016)
"Our main objective was to investigate the effect of chronic administration of hydrogen sulphide donor (sodium hydrosulphide) on the expression of intercellular adhesion molecule-1 (ICAM-1) and concentration of nuclear factor-kappa B (NF-kB) in a renal ischemia-reperfusion injury (IRI) model of WKY and L-nitro-arginine-methyl-ester (L-NAME)-induced hypertensive rats."1.62Hydrogen Sulphide Treatment Prevents Renal Ischemia-Reperfusion Injury by Inhibiting the Expression of ICAM-1 and NF-kB Concentration in Normotensive and Hypertensive Rats. ( Ahmad, A; Chia, TY; Gan, CY; Hashmi, SF; Johns, EJ; Rathore, HA; Sattar, MA, 2021)
"Hydrogen sulfide (H2S) plays an important role in renal physiological and pathophysiological processes."1.43Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice. ( Chen, M; Gao, B; Ji, A; Li, H; Li, M; Li, Y; Ma, C; Wang, S; Wu, D; Yao, L, 2016)
"Hydrogen sulfide is a mediator of IRI and can ameliorate tissue injury in many organ systems."1.42Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats. ( Furness, P; Hosgood, SA; Hunter, JP; Nicholson, ML; Patel, M; Sayers, RD, 2015)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's19 (70.37)24.3611
2020's8 (29.63)2.80

Authors

AuthorsStudies
Hashmi, SF1
Rathore, HA2
Sattar, MA1
Johns, EJ2
Gan, CY1
Chia, TY1
Ahmad, A2
Wang, S3
Liu, X1
Liu, Y1
Sun, HJ1
Leng, B1
Wu, ZY1
Bian, JS1
Wijerathne, CUB1
Madduma Hewage, S1
Siow, YL1
O, K1
Yan, L1
Jiaqiong, L1
Yue, G1
Xiaoyong, L1
Xuexian, T1
Ming, L1
Yinglan, L1
Xinxue, L1
Zena, H1
Roorda, M1
Miljkovic, JL1
van Goor, H2
Henning, RH1
Bouma, HR1
Su, Y1
Wang, Y1
Liu, M1
Chen, H1
Kasinath, BS1
Lee, HJ1
Martin-Lorenzo, M1
Gonzalez-Calero, L1
Ramos-Barron, A1
Sanchez-Niño, MD1
Gomez-Alamillo, C1
García-Segura, JM1
Ortiz, A1
Arias, M1
Vivanco, F1
Alvarez-Llamas, G1
Sekijima, M1
Sahara, H1
Miki, K1
Villani, V1
Ariyoshi, Y1
Iwanaga, T1
Tomita, Y1
Yamada, K1
Hashmp, SF1
Sattar, MZA1
Ahmadi, A1
Chen, Y2
Jin, S1
Teng, X1
Hu, Z1
Zhang, Z1
Qiu, X1
Tian, D1
Wu, Y1
Ozatik, FY1
Teksen, Y1
Kadioglu, E1
Ozatik, O1
Bayat, Z1
Yuan, Y1
Zhu, L1
Li, L1
Liu, J1
Cheng, J1
Peng, T1
Lu, Y1
Jiang, D1
Zhang, Y1
Yang, M1
Jiang, Z1
Li, Z1
Otunctemur, A1
Ozbek, E1
Dursun, M1
Sahin, S1
Besiroglu, H1
Ozsoy, OD1
Cekmen, M1
Somay, A1
Ozbay, N1
Hunter, JP2
Hosgood, SA2
Patel, M2
Furness, P1
Sayers, RD1
Nicholson, ML2
Kaur, S1
Schwartz, AL1
Miller, TW1
Roberts, DD1
Han, B1
Zhao, ZG1
Zhang, LM1
Li, SG1
Niu, CY1
Azizi, F1
Seifi, B1
Kadkhodaee, M1
Ahghari, P1
Oosterhuis, NR1
Frenay, AR1
Wesseling, S1
Snijder, PM1
Slaats, GG1
Yazdani, S1
Fernandez, BO1
Feelisch, M1
Giles, RH1
Verhaar, MC1
Joles, JA1
Olah, G1
Szczesny, B1
Wood, ME1
Whiteman, M1
Szabo, C1
Rovcanin, B1
Medic, B1
Kocic, G1
Cebovic, T1
Ristic, M1
Prostran, M1
Markó, L1
Szijártó, IA1
Filipovic, MR1
Kaßmann, M1
Balogh, A1
Park, JK1
Przybyl, L1
N'diaye, G1
Krämer, S1
Anders, J1
Ishii, I1
Müller, DN1
Gollasch, M1
Wu, D1
Gao, B1
Li, M1
Yao, L1
Chen, M1
Li, H1
Ma, C1
Ji, A1
Li, Y1
Regner, KR1
Roman, RJ1
Rose, R1
Read, K1

Reviews

4 reviews available for hydrogen sulfide and Acute Kidney Injury

ArticleYear
Spatiotemporal regulation of hydrogen sulfide signaling in the kidney.
    Redox biology, 2021, Volume: 43

    Topics: Acute Kidney Injury; Animals; Hydrogen Sulfide; Kidney; Nitric Oxide; Signal Transduction

2021
A CRITICAL REVIEW ON PHARMACOLOGICAL SIGNIFICANCE OF HYDROGEN SULFIDE (H₂S) ON NF-κB CONCENTRATION AND ICAM-1 EXPRESSION IN RENAL ISCHEMIA REPERFUSION INJURY.
    Acta poloniae pharmaceutica, 2017, Volume: 74, Issue:3

    Topics: Acute Kidney Injury; Animals; Humans; Hydrogen Sulfide; Intercellular Adhesion Molecule-1; Kidney; K

2017
Molecular Dissection of Renal Ischemia-Reperfusion: Oxidative Stress and Cellular Events.
    Current medicinal chemistry, 2016, Volume: 23, Issue:19

    Topics: Acute Kidney Injury; Gene Expression; Heat-Shock Proteins; Humans; Hydrogen Sulfide; Inflammation; M

2016
Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury.
    Current opinion in nephrology and hypertension, 2012, Volume: 21, Issue:1

    Topics: Acute Kidney Injury; Angiopoietin-1; Animals; Atrial Natriuretic Factor; Carbon Monoxide; Heme Oxyge

2012

Trials

1 trial available for hydrogen sulfide and Acute Kidney Injury

ArticleYear
Administration of hydrogen sulfide protects ischemia reperfusion-induced acute kidney injury by reducing the oxidative stress.
    Irish journal of medical science, 2016, Volume: 185, Issue:3

    Topics: Acute Kidney Injury; Animals; Hydrogen Sulfide; Kidney; Male; Oxidative Stress; Rats; Rats, Wistar;

2016

Other Studies

22 other studies available for hydrogen sulfide and Acute Kidney Injury

ArticleYear
Hydrogen Sulphide Treatment Prevents Renal Ischemia-Reperfusion Injury by Inhibiting the Expression of ICAM-1 and NF-kB Concentration in Normotensive and Hypertensive Rats.
    Biomolecules, 2021, 10-19, Volume: 11, Issue:10

    Topics: Acute Kidney Injury; Animals; Gene Expression Regulation; Humans; Hydrogen Sulfide; Intercellular Ad

2021
Hydrogen sulfide protects from acute kidney injury via attenuating inflammation activated by necroptosis in dogs.
    Journal of veterinary science, 2022, Volume: 23, Issue:5

    Topics: Acute Kidney Injury; Adenosine Diphosphate Ribose; Animals; Cisplatin; Dog Diseases; Dogs; Hydrogen

2022
Polysulfide and Hydrogen Sulfide Ameliorate Cisplatin-Induced Nephrotoxicity and Renal Inflammation through Persulfidating STAT3 and IKKβ.
    International journal of molecular sciences, 2020, Oct-21, Volume: 21, Issue:20

    Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Cisplatin; Hydrogen Sulfide; I-kappa B Kinase;

2020
Kidney Ischemia-Reperfusion Decreases Hydrogen Sulfide and Increases Oxidative Stress in the Heart.
    Biomolecules, 2020, 11-17, Volume: 10, Issue:11

    Topics: Acute Kidney Injury; Animals; Female; Hydrogen Sulfide; Male; Myocardium; Oxidative Stress; Rats; Ra

2020
Atorvastatin protects against contrast-induced acute kidney injury via upregulation of endogenous hydrogen sulfide.
    Renal failure, 2020, Volume: 42, Issue:1

    Topics: Acute Kidney Injury; Animals; Apoptosis; Atorvastatin; Contrast Media; Cystathionine beta-Synthase;

2020
Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition.
    Molecular medicine reports, 2021, Volume: 24, Issue:1

    Topics: Acute Kidney Injury; Animals; Apoptosis; Caspase 1; Gene Expression Regulation; Heme Oxygenase-1; Hy

2021
Hydrogen Sulfide and the Kidney.
    Advances in experimental medicine and biology, 2021, Volume: 1315

    Topics: Acute Kidney Injury; Gasotransmitters; Humans; Hydrogen Sulfide; Kidney; Oxidative Stress

2021
Urine metabolomics insight into acute kidney injury point to oxidative stress disruptions in energy generation and H
    Journal of molecular medicine (Berlin, Germany), 2017, Volume: 95, Issue:12

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Energy Metabolism; Female; Gene Expression Regu

2017
Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine.
    The Journal of surgical research, 2017, Volume: 219

    Topics: Acute Kidney Injury; Animals; Female; Gasotransmitters; Hydrogen Sulfide; Infusions, Intra-Arterial;

2017
Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress.
    Oxidative medicine and cellular longevity, 2018, Volume: 2018

    Topics: Acute Kidney Injury; Animals; Hydrogen Sulfide; Inflammation; Lipopolysaccharides; Male; Mice; Oxida

2018
Effects of hydrogen sulfide on acetaminophen-induced acute renal toxicity in rats.
    International urology and nephrology, 2019, Volume: 51, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Acute-Phase Proteins; Analgesics, Non-Narcotic;

2019
S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury.
    Antioxidants & redox signaling, 2019, Volume: 31, Issue:17

    Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Cells, Cultured; Cisp

2019
Exogenous hydrogen sulfide prevents kidney damage following unilateral ureteral obstruction.
    Neurourology and urodynamics, 2014, Volume: 33, Issue:5

    Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Fibrosis; Gasotransmitters; Hydrogen Sulfide;

2014
Protective effect of hydrogen sulfide on gentamicin-induced renal injury.
    Renal failure, 2014, Volume: 36, Issue:6

    Topics: Acute Kidney Injury; Animals; Drug Evaluation, Preclinical; Gentamicins; Hydrogen Sulfide; Kidney; M

2014
Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats.
    Annals of vascular surgery, 2015, Volume: 29, Issue:2

    Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Constriction; Disease Mode

2015
CD47-dependent regulation of H₂S biosynthesis and signaling in T cells.
    Methods in enzymology, 2015, Volume: 555

    Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Asthma

2015
Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:7

    Topics: Acute Kidney Injury; Alkynes; Animals; Creatinine; Cystathionine gamma-Lyase; Cytokines; Drainage; E

2015
DL-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats.
    Nitric oxide : biology and chemistry, 2015, Sep-15, Volume: 49

    Topics: Acute Kidney Injury; Alkynes; Angiotensin II; Animals; Blood Pressure; Cell Proliferation; Glycine;

2015
AP39, A Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo.
    Shock (Augusta, Ga.), 2016, Volume: 45, Issue:1

    Topics: Acute Kidney Injury; Animals; Cell Hypoxia; Cells, Cultured; Cytoprotection; Dose-Response Relations

2016
Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury.
    Scientific reports, 2016, 06-08, Volume: 6

    Topics: Acute Kidney Injury; Animals; Cystathionine gamma-Lyase; Hydrogen Sulfide; Kidney; Mice; Mice, Trans

2016
Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Acute Kidney Injury; Animals; Diet, High-Fat; Hydrogen Sulfide; Male; Mice; Mice, Inbred C57BL; Mice

2016
Effects of hydrogen sulphide in an experimental model of renal ischaemia-reperfusion injury.
    The British journal of surgery, 2012, Volume: 99, Issue:12

    Topics: Acute Kidney Injury; Animals; Biomarkers; Constriction; Creatinine; Disease Models, Animal; Female;

2012