Page last updated: 2024-10-18

hydrogen carbonate and Proteinuria

hydrogen carbonate has been researched along with Proteinuria in 46 studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.

Research Excerpts

ExcerptRelevanceReference
"Tenidap is a novel antirheumatic agent that causes a mild, reversible proteinuria in human clinical trials."7.69Model development and analysis of tenidap-induced proteinuria in the rat. ( Aleo, MD; Giebisch, G; Lopez-Anaya, A; Sanders, MJ; Walsh, AH; Wang, T, 1996)
" The evolution of blood pressure (BP) control, CRP levels, nutritional data (body mass index, serum albumin, prealbumin, transferrin, cholesterol), proteinuria, calcium-phosphorus product, bicarbonate, haemoglobin (Hb), the weekly dose of erythropoietin (Epo)/kg body weight, and the Hb/Epo dose ratio were measured and compared between patients with high (>6 mg/l) or low (<6 mg/l) CRP levels at baseline."3.71Significance of high C-reactive protein levels in pre-dialysis patients. ( Carreño, A; Espejo, B; Gallar, P; Gutierrez, M; Jimenez, J; Oliet, A; Ortega, O; Ortiz, M; Rodriguez, I; Vigil, A, 2002)
"Tenidap is a novel antirheumatic agent that causes a mild, reversible proteinuria in human clinical trials."3.69Model development and analysis of tenidap-induced proteinuria in the rat. ( Aleo, MD; Giebisch, G; Lopez-Anaya, A; Sanders, MJ; Walsh, AH; Wang, T, 1996)
"Although hyperkalemia is a well-recognized complication of CKD, the prevalence rates of hyperkalemia (14%-20%) and hypokalemia (12%-18%) are similar."2.55Hyperkalemia and Hypokalemia in CKD: Prevalence, Risk Factors, and Clinical Outcomes. ( Gilligan, S; Raphael, KL, 2017)
"Metabolic acidosis is common in chronic kidney disease (CKD) and may have various deleterious consequences."1.51Metabolic acidosis is associated with pulse wave velocity in chronic kidney disease: Results from the KNOW-CKD Study. ( Ahn, C; Han, M; Kang, E; Kim, HJ; Kim, YS; Lee, KB; Oh, KH; Ryu, H; Sung, S, 2019)
"Proteinuria was obtained from a 24-h urine collection."1.40In chronic kidney disease, serum α-Klotho is related to serum bicarbonate and proteinuria. ( Cuerq, C; Drai, J; Dubourg, L; Fouque, D; Hadj-Aissa, A; Hage, V; Laville, M; Lemoine, S; Pelletier, S, 2014)
"Metabolic acidosis is a consequence of chronic renal failure and it may produce bone demineralization, muscle proteolysis, and progression of chronic renal failure."1.32Calcium citrate ameliorates the progression of chronic renal injury. ( Boggia, J; Ferreiro, A; Gadola, L; García, S; Márquez, MN; Musto, ML; Nin, N; Noboa, O; Ortega, V; Pizarrosa, C; Ponte, P; Ravaglio, S; Rodriguez, MJ; Sesser, P; Vallega, A, 2004)
"The metabolic acidosis was a consistent finding and was severe in all cats (venous pH, 7."1.26Characterization and treatment of acid-base and renal defects due to urethral obstruction in cats. ( Bovée, KC; Burrows, CF, 1978)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199024 (52.17)18.7374
1990's6 (13.04)18.2507
2000's9 (19.57)29.6817
2010's6 (13.04)24.3611
2020's1 (2.17)2.80

Authors

AuthorsStudies
Meremo, A1
Paget, G1
Duarte, R1
Dickens, C1
Dix-Peek, T1
Bintabara, D1
Naicker, S1
Kim, HJ1
Kang, E1
Ryu, H1
Han, M1
Lee, KB1
Kim, YS1
Sung, S1
Ahn, C1
Oh, KH1
Gilligan, S1
Raphael, KL2
Hage, V1
Pelletier, S1
Dubourg, L1
Drai, J1
Cuerq, C1
Lemoine, S1
Hadj-Aissa, A1
Laville, M1
Fouque, D1
Mehta, RL1
Awdishu, L1
Davenport, A1
Murray, PT1
Macedo, E1
Cerda, J1
Chakaravarthi, R1
Holden, AL1
Goldstein, SL1
Dad, T1
Garimella, PS1
Strom, JA1
Zahmatkesh, M1
Kadkhodaee, M1
Seifi, B1
Shams, S1
Wei, G1
Baird, BC1
Greene, T1
Beddhu, S1
BORMAN, JB1
DAVIDSON, JT1
BLONDHEIM, SH1
TESCHAN, PE1
MASON, AD1
Gadola, L1
Noboa, O1
Márquez, MN1
Rodriguez, MJ1
Nin, N1
Boggia, J1
Ferreiro, A1
García, S1
Ortega, V1
Musto, ML1
Ponte, P1
Sesser, P1
Pizarrosa, C1
Ravaglio, S1
Vallega, A1
Li, SL1
Liou, LB1
Fang, JT1
Tsai, WP1
Igarashi, T1
Sabbatini, ME1
Rodríguez, MR1
Dabas, P1
Vatta, MS1
Bianciotti, LG1
Backman, U2
Danielson, BG2
Johansson, G2
Ljunghall, S2
Wikström, B1
Hannaford, MC1
Leiter, LA1
Josse, RG1
Goldstein, MB1
Marliss, EB1
Halperin, ML1
Aleo, MD1
Wang, T1
Giebisch, G1
Sanders, MJ1
Walsh, AH1
Lopez-Anaya, A1
Ong-ajyooth, L1
Malasit, P1
Ong-ajyooth, S1
Fucharoen, S1
Pootrakul, P1
Vasuvattakul, S1
Siritanaratkul, N1
Nilwarangkur, S1
Mazouz, H1
Kacso, I1
Ghazali, A1
El Esper, N1
Moriniere, P1
Makdassi, R1
Hardy, P1
Westeel, PF1
Achard, JM1
Pruna, A1
Fournier, A1
Aparicio, M1
Chauveau, P1
Précigout, V1
Bouchet, JL1
Lasseur, C1
Combe, C1
Mahoney, CP1
Striker, GE1
Tanaka, M1
Schmidlin, O1
Olson, JL1
Yi, SL1
Morris, RC1
Ortega, O1
Rodriguez, I1
Gallar, P1
Carreño, A1
Ortiz, M1
Espejo, B1
Jimenez, J1
Gutierrez, M1
Oliet, A1
Vigil, A1
Sohtell, M1
Litkowski, LJ1
Wilson, TL1
Ling, GV1
Lowenstine, LJ1
Pulley, LT1
Kaneko, JJ1
Burrows, CF1
Bovée, KC1
Cade, R1
Spooner, G1
Juncos, L1
Fuller, T1
Tarrant, D1
Raulerson, D1
Mahoney, J1
Pickering, M1
Grubb, W1
Marbury, T1
Wechsler, D1
Ibsen, L1
Fosarelli, P1
Odum, L1
Hansen-Nord, G1
Nielsen, CA1
Nath, KA2
Salahudeen, AK1
Hostetter, MK1
Hostetter, TH1
Trevisan, R1
Nosadini, R1
Fioretto, P1
Avogaro, A1
Duner, E1
Jori, E1
Valerio, A1
Doria, A1
Crepaldi, G1
Bichler, KH1
Porzsolt, F1
Naber, K1
Bennett, WM1
Hempel, KH1
Berland, JE1
Porter, GA1
Kavanagh, T1
Shephard, RH1
Pandit, V1
Purvis, ML1
Buckalew, VM1
Hall, PW1
Piscator, M1
Vasiljević, M1
Popović, N1
Unzelman, RF1
Alderfer, GR1
Chojnacki, RE1
Abbassi, V1
Lowe, CU1
Calcagno, PL1
Hoyle, CL1
McCall, DC1
Danford, RO1
DeSuto-Nagy, GI1
Hayes, MA1
Raska, B1
Rossmann, P1
Hamanová, J1
Edwards, OM1
Edwards, P1
Huskisson, EC1
Taylor, RT1
Klete, H1
Knochel, JP1
Buitendag, B1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Genetic Contribution to Drug Induced Renal Injury: The Drug Induced Renal Injury Consortium (DIRECT)[NCT02159209]634 participants (Actual)Observational2013-02-28Completed
Randomized Trial of Sodium Bicarbonate in Renal Transplant Recipients With Low-normal Serum Bicarbonate Levels[NCT01225796]Early Phase 129 participants (Actual)Interventional2010-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for hydrogen carbonate and Proteinuria

ArticleYear
Hyperkalemia and Hypokalemia in CKD: Prevalence, Risk Factors, and Clinical Outcomes.
    Advances in chronic kidney disease, 2017, Volume: 24, Issue:5

    Topics: Age Factors; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bicarbonate

2017
[Dent disease (idiopathic tubular proteinuria): Pathogenesis, pathophysiology, and therapy].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 2

    Topics: Animals; Bicarbonates; Calcinosis; Calcium; Chloride Channels; Glomerulosclerosis, Focal Segmental;

2006
Oculo-cerebro-renal syndrome. A review.
    American journal of diseases of children (1960), 1968, Volume: 115, Issue:2

    Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Amino Acids; Bicarbonates; Bone Diseases; Brain Dise

1968

Trials

1 trial available for hydrogen carbonate and Proteinuria

ArticleYear
Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans.
    Kidney international, 2011, Volume: 79, Issue:3

    Topics: Adult; Aged; Antihypertensive Agents; Bicarbonates; Biomarkers; Black or African American; Chronic D

2011

Other Studies

42 other studies available for hydrogen carbonate and Proteinuria

ArticleYear
Demographic and clinical profile of black patients with chronic kidney disease attending a tertiary hospital in Johannesburg, South Africa.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Acidosis; Aged; Allopurinol; Anemia; Bicarbonates; Cross-Sectional Studies; Diabetes Mellitus; Doxaz

2022
Metabolic acidosis is associated with pulse wave velocity in chronic kidney disease: Results from the KNOW-CKD Study.
    Scientific reports, 2019, 11-06, Volume: 9, Issue:1

    Topics: Acidosis; Adult; Aged; Ankle Brachial Index; Bicarbonates; Cholesterol; Cross-Sectional Studies; Fem

2019
In chronic kidney disease, serum α-Klotho is related to serum bicarbonate and proteinuria.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2014, Volume: 24, Issue:6

    Topics: Adult; Aging; Bicarbonates; Biomarkers; C-Reactive Protein; Creatinine; Cross-Sectional Studies; Fem

2014
Phenotype standardization for drug-induced kidney disease.
    Kidney international, 2015, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Bicarbonates; Biopsy; Consensus; Creatinine; Delphi Technique; Electrolytes; Gl

2015
Quiz: An Unusual Case of Metabolic Alkalosis in a Patient With CKD.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017, Volume: 69, Issue:1

    Topics: Aged, 80 and over; Alkalosis; Antacids; Bicarbonates; Chelating Agents; Creatinine; Diagnosis, Diffe

2017
Effect of bicarbonate administration on cyclosporine-induced nephrotoxicity in rats.
    Transplantation proceedings, 2009, Volume: 41, Issue:7

    Topics: Acetylglucosaminidase; Animals; Bicarbonates; Creatinine; Cyclosporine; Immunosuppressive Agents; Ki

2009
IDIOPATHIC RHABDOMYOLYSIS (MYOGLOBINURIA) AS AN ACUTE RESPIRATORY PROBLEM.
    British medical journal, 1963, Sep-21, Volume: 2, Issue:5359

    Topics: Bicarbonates; Heart Arrest; Heart Massage; Myoglobin; Myoglobinuria; Positive-Pressure Respiration;

1963
STUDIES IN ACUTE RENAL FAILURE. II. INCIDENCE, MORTALITY, URINARY AND PLASMA CHEMICAL ALTERATIONS AND CLINICAL CHARACTERISTICS OF REVERSIBLE ACUTE RENAL FAILURE IN THE RAT.
    The Journal of surgical research, 1963, Volume: 3

    Topics: Acute Kidney Injury; Bicarbonates; Blood Chemical Analysis; Diuresis; Ferrocyanides; Incidence; Meth

1963
Calcium citrate ameliorates the progression of chronic renal injury.
    Kidney international, 2004, Volume: 65, Issue:4

    Topics: Alkalies; Animals; Bicarbonates; Calcium Citrate; Captopril; Cell Division; Disease Progression; Dru

2004
Symptomatic renal tubular acidosis (RTA) in patients with systemic lupus erythematosus: an analysis of six cases with new association of type 4 RTA.
    Rheumatology (Oxford, England), 2005, Volume: 44, Issue:9

    Topics: Acidosis, Renal Tubular; Adult; Bicarbonates; Female; Glucocorticoids; Humans; Lupus Erythematosus,

2005
C-type natriuretic peptide stimulates pancreatic exocrine secretion in the rat: role of vagal afferent and efferent pathways.
    European journal of pharmacology, 2007, Dec-22, Volume: 577, Issue:1-3

    Topics: Afferent Pathways; Animals; Autonomic Nervous System; Bicarbonates; Chlorides; Cholecystokinin; Dose

2007
Incidence and clinical importance of renal tubular defects in recurrent renal stone formers.
    Nephron, 1980, Volume: 25, Issue:2

    Topics: Acid-Base Equilibrium; Adult; Bicarbonates; Cyclic AMP; Female; Humans; Hydrogen-Ion Concentration;

1980
Protein wasting due to acidosis of prolonged fasting.
    The American journal of physiology, 1982, Volume: 243, Issue:3

    Topics: Acidosis; Adult; Bicarbonates; Blood Urea Nitrogen; Fasting; Female; Humans; Ketone Bodies; Ketosis;

1982
Model development and analysis of tenidap-induced proteinuria in the rat.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:3

    Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicarbonates; Disease Models, Animal; Do

1996
Renal function in adult beta-thalassemia/Hb E disease.
    Nephron, 1998, Volume: 78, Issue:2

    Topics: Acetylglucosaminidase; Adult; Ammonia; beta 2-Microglobulin; beta-Thalassemia; Bicarbonates; Creatin

1998
Risk factors of renal failure progression two years prior to dialysis.
    Clinical nephrology, 1999, Volume: 51, Issue:6

    Topics: Anemia; Bicarbonates; Blood Proteins; Calcium; Cholesterol; Creatinine; Diabetic Nephropathies; Dise

1999
Nutrition and outcome on renal replacement therapy of patients with chronic renal failure treated by a supplemented very low protein diet.
    Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bicarbonates; Diet, Protein-Restricted; Female; Glomerul

2000
Early development of the renal lesions in infantile cystinosis.
    Pediatric nephrology (Berlin, Germany), 2000, Volume: 15, Issue:1-2

    Topics: Amino Acids; Bicarbonates; Biopsy; Cystinosis; Glycosuria; Humans; Infant; Kidney; Kidney Function T

2000
Chloride-sensitive renal microangiopathy in the stroke-prone spontaneously hypertensive rat.
    Kidney international, 2001, Volume: 59, Issue:3

    Topics: Animals; Bicarbonates; Blood Pressure; Chlorides; Creatinine; Disease Susceptibility; Hypertension;

2001
Significance of high C-reactive protein levels in pre-dialysis patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17, Issue:6

    Topics: Bicarbonates; Biomarkers; Blood Pressure; C-Reactive Protein; Cholesterol; Cohort Studies; Hemoglobi

2002
[Kidney function in kidney calculi patients].
    Lakartidningen, 1978, May-10, Volume: 75, Issue:19

    Topics: beta 2-Microglobulin; Bicarbonates; Humans; Hydrogen-Ion Concentration; Kidney; Kidney Calculi; Kidn

1978
Effect of protein on titrimetry of bicarbonate, titratable acid, and ammonium in urine.
    Clinical chemistry, 1979, Volume: 25, Issue:3

    Topics: Acid-Base Equilibrium; Ammonia; Bicarbonates; Humans; Hydrogen-Ion Concentration; Methods; Proteinur

1979
Diabetes mellitus in dogs: a review of initial evaluation, immediate and long-term management, and outcome.
    Journal of the American Veterinary Medical Association, 1977, Mar-01, Volume: 170, Issue:5

    Topics: Amylases; Animals; Anorexia; Bicarbonates; Blood Glucose; Blood Urea Nitrogen; Cushing Syndrome; Deh

1977
Characterization and treatment of acid-base and renal defects due to urethral obstruction in cats.
    Journal of the American Veterinary Medical Association, 1978, Apr-01, Volume: 172, Issue:7

    Topics: Acid-Base Imbalance; Acidosis; Animals; Bicarbonates; Cat Diseases; Cats; Infusions, Parenteral; Kid

1978
Chronic renal vein thrombosis.
    The American journal of medicine, 1977, Volume: 63, Issue:3

    Topics: Adolescent; Adult; Aged; Angiography; Bicarbonates; Biopsy; Chlorides; Chronic Disease; Female; Fibr

1977
Apparent proteinuria as a consequence of sodium bicarbonate ingestion.
    Pediatrics, 1990, Volume: 86, Issue:2

    Topics: Bicarbonates; Humans; Infant; Male; Proteinuria; Sodium; Sodium Bicarbonate

1990
Reversible microproteinuria induced by L-aspartate infusion.
    Nephron, 1990, Volume: 56, Issue:1

    Topics: Adult; Albuminuria; Arginine; Aspartic Acid; beta 2-Microglobulin; Bicarbonates; Female; Glycoprotei

1990
Induction of renal growth and injury in the intact rat kidney by dietary deficiency of antioxidants.
    The Journal of clinical investigation, 1990, Volume: 86, Issue:4

    Topics: Ammonia; Animals; Antioxidants; Bicarbonates; Growth; Hemodynamics; Iron; Kidney; Lipid Peroxidation

1990
Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3.
    The Journal of clinical investigation, 1985, Volume: 76, Issue:2

    Topics: Acid-Base Equilibrium; Ammonia; Animals; Bicarbonates; Complement C3; Complement Pathway, Alternativ

1985
Ketone bodies increase glomerular filtration rate in normal man and in patients with type 1 (insulin-dependent) diabetes mellitus.
    Diabetologia, 1987, Volume: 30, Issue:4

    Topics: Acetoacetates; Bicarbonates; Diabetes Mellitus, Type 1; Female; Glomerular Filtration Rate; Hemodyna

1987
[Proteinuria after physical exercise].
    Deutsche medizinische Wochenschrift (1946), 1972, Aug-25, Volume: 97, Issue:34

    Topics: Acidosis; Adult; Albuminuria; Beta-Globulins; Bicarbonates; Ceruloplasmin; Creatinine; Glycoproteins

1972
Renal tubular acidosis.
    Archives of internal medicine, 1968, Volume: 121, Issue:1

    Topics: Acidosis, Renal Tubular; Bicarbonates; Blood Urea Nitrogen; Chronic Disease; Electrolytes; Fanconi S

1968
Marathon running after myocardial infarction.
    JAMA, 1974, Sep-16, Volume: 229, Issue:12

    Topics: Adult; Bicarbonates; Blood Glucose; Blood Pressure; Body Weight; Cell Membrane Permeability; Chlorid

1974
Lysozymuria in distal renal tubular acidosis.
    Nephron, 1974, Volume: 13, Issue:6

    Topics: Acidosis, Renal Tubular; Adult; Bicarbonates; Chromatography, DEAE-Cellulose; Female; Humans; Hydrog

1974
Renal function studies in indivuals with the tubular proteinuria of endemic Balkan nephropathy.
    The Quarterly journal of medicine, 1972, Volume: 41, Issue:164

    Topics: Ammonia; Bicarbonates; Creatinine; Electrophoresis; Glycosuria; Humans; Hydrogen-Ion Concentration;

1972
Pregnancy and chronic hemodialysis.
    Transactions - American Society for Artificial Internal Organs, 1973, Volume: 19

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bicarbonates; Bile A

1973
Renal function during the early post-burn period: a comparison of colloid versus non-colloid containing balanced salt solution.
    Annals of surgery, 1969, Volume: 169, Issue:3

    Topics: Albumins; Animals; Bicarbonates; Blood Pressure; Blood Proteins; Burns; Central Venous Pressure; Col

1969
[Unusual tubular disorder with hypopotassemia and retinitis pigmentosa in a 9-year-old girl].
    Ceskoslovenska pediatrie, 1970, Volume: 25, Issue:6

    Topics: Bicarbonates; Blood; Child; Female; Glycosuria; Humans; Hydrogen-Ion Concentration; Hypokalemia; Kid

1970
Paracetamol and renal damage.
    British medical journal, 1971, Apr-10, Volume: 2, Issue:5753

    Topics: Acetaminophen; Aged; Bacteriuria; Bicarbonates; Creatinine; Female; Hemoglobinometry; Humans; Kidney

1971
[The serum magnesium level in kidney diseases].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1967, Dec-01, Volume: 22, Issue:23

    Topics: Acute Kidney Injury; Bicarbonates; Blood Proteins; Calcium; Cholesterol; Chronic Disease; Female; Gl

1967
Hematuria in sickle cell trait: the effect of intravenous administration of distilled water, urinary alkalinization, and diuresis.
    Archives of internal medicine, 1969, Volume: 123, Issue:2

    Topics: Adult; Anemia, Sickle Cell; Bicarbonates; Blood Cell Count; Creatinine; Cystoscopy; Diuresis; Erythr

1969
[The hemolytic-uremic syndrome].
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1969, Mar-29, Volume: 43, Issue:13

    Topics: Acute Kidney Injury; Anemia, Hemolytic; Bicarbonates; Blood Platelets; Child, Preschool; Diagnosis,

1969