hydrogen carbonate and Pre-Eclampsia studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.

Research Excerpts

Excerpt	Relevance	Reference
"We report a case of baking powder pica during pregnancy that was associated with maternal hypertension, hypokalemia, and elevated liver function tests."	7.68	Baking powder pica mimicking preeclampsia. ( Barton, JR; Riely, CA; Sibai, BM, 1992)
"We report a case of baking powder pica during pregnancy that was associated with maternal hypertension, hypokalemia, and elevated liver function tests."	3.68	Baking powder pica mimicking preeclampsia. ( Barton, JR; Riely, CA; Sibai, BM, 1992)
"Fifty women with severe preeclampsia, 25 healthy non-pregnant- and 46 healthy pregnant controls (26-40 weeks' gestation), were enrolled in this prospective case-control study."	2.80	Strong ion and weak acid analysis in severe preeclampsia: potential clinical significance. ( Allie, S; Cain, K; Combrinck, B; Dyer, RA; Landau, R; Ortner, CM; Story, D, 2015)
"Severe preeclampsia affects placental function and causes fetal compromise."	1.28	The value of cordocentesis in management of patients with severe preeclampsia. ( Chiu, TH; Hsieh, TT; Kuo, DM; Lo, LM, 1991)

Research

Studies (19)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Mean Umbilical Artery Lactate at Delivery

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (73.68)	18.7374
1990's	3 (15.79)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (10.53)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Markovic, S	1
Fages, A	1
Roussel, T	1
Hadas, R	1
Brandis, A	1
Neeman, M	1
Frydman, L	1
Ortner, CM	1
Combrinck, B	1
Allie, S	1
Story, D	1
Landau, R	1
Cain, K	1
Dyer, RA	1
COMBRINK, PB	1
BLECHER, JA	1
RAIHA, NC	1
KAURANIEMI, TV	1
Westgren, M	1
Divon, M	1
Horal, M	1
Ingemarsson, I	1
Kublickas, M	1
Shimojo, N	1
Nordström, L	1
Fadel, HE	1
Northrop, G	1
Misenhimer, HR	1
Harp, RJ	1
Tanev, AV	1
Barton, JR	1
Riely, CA	1
Sibai, BM	1
Hsieh, TT	1
Kuo, DM	1
Lo, LM	1
Chiu, TH	1
Wendt, M	1
Bickhardt, K	1
Kronfeld, DS	1
McCarthy, GT	1
O'Connell, B	1
Robinson, AE	1
Fish, SA	1
Morrison, JC	1
Bucovaz, ET	1
Wiser, WL	1
Whybrew, WD	1
Linari, F	1
Ragni, R	1
Stratta, P	1
Dogliani, M	1
Malato, M	1
Arienzo, R	1
Dziewulska, W	1
Kretowicz, J	1
Wójcicka, J	1
Roszkowski, I	1
Krause, W	1
Arosio, G	1
Bertolizio, G	1
Frangipani, GC	1
Bartoli, E	1
Revelli, E	1
Molaschi, M	1
Sismondi, P	1
Sartoris, S	1
Massobrio, M	1
Bocci, A	1
Pupita, F	1

Trial	Enrollment	Study Type	Start Date	Status
Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach[NCT02164370]	120 participants (Actual)	Observational	2013-10-31	Completed
Oxygen for Category II Intrauterine Fetal Resuscitation: A Randomized, Noninferiority Trial[NCT02741284]	114 participants (Actual)	Interventional	2016-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Determined by umbilical artery cord gas collected at time of delivery and only in patients with paired (umbilical artery and umbilical vein) cord gases. (NCT02741284)
Timeframe: At delivery

Number of Patients With Resolved Recurrent Decelerations

Intervention	mmol/L (Mean)
Room Air	3.5
Oxygen	3.4

Number of patients with resolution of recurrent variable or recurrent late decelerations within 60 minutes of randomization (NCT02741284)
Timeframe: 60 minutes after randomization

Umbilical Artery Base Deficit

Intervention	Participants (Count of Participants)
No Oxygen	49
Oxygen	43

As determined by cord gas collection at time of delivery (NCT02741284)
Timeframe: At time of delivery

Umbilical Artery pCO2

Intervention	meq/L (Mean)
Room Air	-3.6
Oxygen	-3.6

Partial pressure of carbon dioxide as collected on cord gases at time of delivery (NCT02741284)
Timeframe: At time of delivery

Umbilical Artery pH

Intervention	mmHg (Mean)
Room Air	55.9
Oxygen	57.4

Determined by umbilical artery cord gas collected at time of delivery and only in patients with paired (umbilical artery and umbilical vein) cord gases. (NCT02741284)
Timeframe: At time of delivery

Umbilical Artery pO2

Intervention	pH units (Mean)
Room Air	7.26
Oxygen	7.25

Partial pressure of oxygen as collected on cord gases at time of delivery (NCT02741284)
Timeframe: Time of delivery

Mode of Delivery

Intervention	mm Hg (Mean)
Room Air	19.7
Oxygen	24.4

Delivery via Cesarean section, operative vaginal delivery (forceps or vacuum), or spontaneous vaginal delivery (NCT02741284)
Timeframe: At delivery

Article	Year
Placental physiology monitored by hyperpolarized dynamic Proceedings of the National Academy of Sciences of the United States of America, 2018, 03-06, Volume: 115, Issue:10 Topics: Animals; Bicarbonates; Carbon Isotopes; Disease Models, Animal; Female; Humans; Lactic Acid; Magneti	2018
SEVERE EARLY TOXAEMIA OF PREGNANCY. A NEW TREATMENT. Lancet (London, England), 1964, Jun-06, Volume: 1, Issue:7345 Topics: Abdomen; Atmospheric Pressure; Bicarbonates; Blood Pressure; Blood Pressure Determination; Chlorothi	1964
Carbon dioxide tension and acid-base balance of human amniotic fluid at the end of gestation. Biologia neonatorum. Neo-natal studies, 1962, Volume: 4 Topics: Acid-Base Equilibrium; Amniotic Fluid; Bicarbonates; Carbon Dioxide; Female; Humans; Pre-Eclampsia;	1962
Routine measurements of umbilical artery lactate levels in the prediction of perinatal outcome. American journal of obstetrics and gynecology, 1995, Volume: 173, Issue:5 Topics: Bicarbonates; Carbon Dioxide; Cesarean Section; Delivery, Obstetric; Female; Fetal Blood; Humans; Hy	1995
Acid base balance in pre-eclamptic, hypertensive and diabetic pregnancies. Maternal blood and amniotic fluid studies. Journal of perinatal medicine, 1979, Volume: 7, Issue:4 Topics: Acid-Base Equilibrium; Adult; Amniotic Fluid; Bicarbonates; Carbon Dioxide; Female; Humans; Hydrogen	1979
[Acid-base equilibrium and its relationship with certain electrolytic and biochemical indicators in late pregnancy toxemias]. Akusherstvo i ginekologiia, 1975, Issue:9 Topics: Acid-Base Equilibrium; Ammonia; Bicarbonates; Carbon Dioxide; Chlorides; Female; Humans; Hydroxyindo	1975
Baking powder pica mimicking preeclampsia. American journal of obstetrics and gynecology, 1992, Volume: 167, Issue:1 Topics: Adult; Alum Compounds; Aspartate Aminotransferases; Bicarbonates; Bilirubin; Black People; Blood Pre	1992
The value of cordocentesis in management of patients with severe preeclampsia. Asia-Oceania journal of obstetrics and gynaecology, 1991, Volume: 17, Issue:1 Topics: Acidosis; Bicarbonates; Carbon Dioxide; Female; Fetal Blood; Fetal Diseases; Humans; Hydrogen-Ion Co	1991
[Stress reactions in sows during difficult births and after transport]. Tierarztliche Praxis. Supplement, 1988, Volume: 3 Topics: Animals; Bicarbonates; Cesarean Section; Creatine Kinase; Dystocia; Female; Fetal Death; Heart Rate;	1988
Blood levels of diazepam in infants of two mothers given large doses of diazepam during labour. The Journal of obstetrics and gynaecology of the British Commonwealth, 1973, Volume: 80, Issue:4 Topics: Adolescent; Adult; Apnea; Asphyxia Neonatorum; Bicarbonates; Cyanosis; Diazepam; Eclampsia; Female;	1973
Cerebral spinal fluid studies in eclampsia. American journal of obstetrics and gynecology, 1972, Feb-15, Volume: 112, Issue:4 Topics: Bicarbonates; Cerebrospinal Fluid; Chlorides; Eclampsia; Female; Hematocrit; Humans; Hypertension; N	1972
[Therapeutic findings in acute renal insufficiency due to gestosis]. Minerva medica, 1972, Jul-28, Volume: 63, Issue:56 Topics: Abortion, Spontaneous; Abruptio Placentae; Acute Kidney Injury; Adult; Bicarbonates; Dextrans; Femal	1972
[The use of the bicarbonate buffer in the treatment of gestosis]. Archivio di ostetricia e ginecologia, 1969, Volume: 74, Issue:6 Topics: Acidosis; Adult; Bicarbonates; Female; Humans; Pre-Eclampsia; Pregnancy	1969
[Acid-base equilibrium in cases of pregnancy toxemias and urinary tract infection in pregnancy]. Ginekologia polska, 1971, Volume: 42, Issue:2 Topics: Acid-Base Equilibrium; Bacteriuria; Bicarbonates; Carbon Dioxide; Female; Humans; Hydrogen-Ion Conce	1971
[Diagnosis of fetal diseases and amniotic fluid gas analysis]. Medizinische Klinik, 1969, Aug-01, Volume: 64, Issue:31 Topics: Amniotic Fluid; Bicarbonates; Carbon Dioxide; Erythroblastosis, Fetal; Female; Fetal Death; Fetal Di	1969
[Study of acid-base equilibrium of the amniotic fluid in the course of normal and pathological pregnancies]. Annali di ostetricia e ginecologia, 1965, Volume: 87, Issue:12 Topics: Amniotic Fluid; Bicarbonates; Blood Group Incompatibility; Carbon Dioxide; Female; Humans; Hydrogen-	1965
[Renal excretion of bicarbonates in normal pregnancy and in gestosis]. Minerva ginecologica, 1966, Mar-15, Volume: 18, Issue:5 Topics: Adult; Bicarbonates; Female; Humans; In Vitro Techniques; Kidney; Pre-Eclampsia; Pregnancy; Urine	1966

hydrogen carbonate and Pre-Eclampsia