hydrogen carbonate and Pancreatitis, Chronic studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Pancreatitis, Chronic: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.

Research Excerpts

Excerpt	Relevance	Reference
" This could contribute to the development of chronic pancreatitis by decreasing luminal pH and promoting premature activation of trypsinogen in the pancreatic ducts."	3.77	Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers. ( Argent, BE; Borka, K; Geisz, A; Gray, MA; Hegyi, P; Judák, L; Korompay, A; Lerch, MM; Maléth, J; Mayerle, J; Ozsvári, B; Pallagi, P; Rakonczay, Z; Sahin-Tóth, M; Schnúr, A; Takács, T; Venglovecz, V; Wittmann, T, 2011)
" Autoimmune pancreatitis accompanied with diabetes mellitus showed a reduction both in DeltaC-peptide response (beta-cell response) and Deltaglucagon (alpha-cell response)."	3.74	Evaluation of pancreatic endocrine and exocrine function in patients with autoimmune pancreatitis. ( Arita, Y; Funakoshi, A; Hisano, T; Igarashi, H; Ito, T; Kawabe, K; Sumii, T; Takayanagi, R; Yamanaka, T, 2007)
"Diagnosis of early chronic pancreatitis is a clinical challenge and hindered by the lack of a gold standard."	1.56	Endoscopic ultrasound-based multimodal evaluation of the pancreas in patients with suspected early chronic pancreatitis. ( Alvarez-Castro, A; de la Iglesia-Garcia, D; Domínguez-Muñoz, JE; Iglesias-Garcia, J; Lariño-Noia, J; Leal, S; Lojo, S; Nieto, L, 2020)
"The diagnosis of chronic pancreatitis is often difficult in the early stages of the disease."	1.35	A rapid, endoscopic exocrine pancreatic function test and the Lundh test: a comparative study. ( Jensen, NM; Larsen, S, 2008)

Research

Studies (31)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Pancreatic Stiffness as Measured by Magnetic Resonance Elastography (MRE)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (6.45)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (25.81)	29.6817
2010's	17 (54.84)	24.3611
2020's	4 (12.90)	2.80

Authors	Studies
Futagami, S	1
Wakabayashi, M	1
Iglesias-Garcia, J	2
Lariño-Noia, J	2
Nieto Bsn, L	1
Alvarez-Castro, A	2
Lojo, S	2
Leal, S	2
de la Iglesia-Garcia, D	2
Domínguez-Muñoz, JE	2
Berke, G	1
Gede, N	1
Szadai, L	1
Ocskay, K	1
Hegyi, P	2
Sahin-Tóth, M	2
Hegyi, E	1
Nieto, L	1
Lara, LF	1
Takita, M	1
Burdick, JS	1
DeMarco, DC	1
Pimentel, RR	1
Erim, T	1
Levy, MF	1
Kothari, D	1
Ketwaroo, G	1
Freedman, SD	1
Sheth, SG	1
Erchinger, F	2
Engjom, T	2
Tjora, E	2
Hoem, D	1
Hausken, T	1
Gilja, OH	2
Dimcevski, G	1
Lærum, BN	1
Georg, D	1
Sainani, NI	2
Kadiyala, V	2
Mortele, K	2
Lee, L	1
Suleiman, S	2
Rosenblum, J	2
Wang, W	2
Banks, PA	3
Conwell, DL	6
Domínguez Muñoz, JE	1
Tirkes, T	1
Fogel, EL	1
Sherman, S	2
Lin, C	1
Swensson, J	1
Akisik, F	1
Sandrasegaran, K	1
Jensen, NM	1
Larsen, S	1
Stevens, T	6
Dumot, JA	3
Zuccaro, G	4
Vargo, JJ	3
Parsi, MA	4
Lopez, R	6
Kirchner, HL	1
Purich, E	3
Zuccaro, P	1
Repas, K	1
Diamond, R	1
Wu, B	1
Xiao, Z	1
Dodig, M	1
Schneider, A	1
Larusch, J	1
Sun, X	1
Aloe, A	1
Lamb, J	1
Hawes, R	1
Cotton, P	1
Brand, RE	1
Anderson, MA	1
Money, ME	1
Lewis, MD	1
Baillie, J	1
Disario, J	1
Burton, FR	1
Gardner, TB	3
Amann, ST	1
Gelrud, A	1
George, R	1
Rockacy, MJ	1
Kassabian, S	1
Martinson, J	1
Slivka, A	1
Yadav, D	1
Oruc, N	1
Barmada, MM	1
Frizzell, R	1
Whitcomb, DC	1
Zhong, N	1
Saenger, AK	1
Topazian, M	1
Gleeson, FC	1
Chari, ST	1
Clain, JE	1
Levy, MJ	1
Rajan, E	1
Enders, FT	1
Pallagi, P	1
Venglovecz, V	1
Rakonczay, Z	1
Borka, K	1
Korompay, A	1
Ozsvári, B	1
Judák, L	1
Geisz, A	1
Schnúr, A	1
Maléth, J	1
Takács, T	1
Gray, MA	1
Argent, BE	1
Mayerle, J	1
Lerch, MM	1
Wittmann, T	1
Purich, ED	1
Gordon, SR	2
Pelley, JR	1
Law, R	1
Costanzo, A	1
Lieb, JG	1
Brensinger, CM	1
Toskes, PP	1
Lee, LS	1
Paulo, JA	1
MUELLER-WIELAND, K	1
THIEMANN, KJ	1
FRIEDMAN, MH	1
SNAPE, WJ	1
Talamini, G	1
Pollack, BJ	1
Grendell, JH	1
Ito, T	1
Kawabe, K	1
Arita, Y	1
Hisano, T	1
Igarashi, H	1
Funakoshi, A	1
Sumii, T	1
Yamanaka, T	1
Takayanagi, R	1
Fein, S	2
VanLente, F	1
Trolli, P	1
Van Lente, F	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Magnetic Resonance Cholangiopancreatography (MRCP): A Reliable, Non Invasive Method for Staging Chronic Pancreatitis From Minimal Change Disease to the Advanced Stages in Pediatrics[NCT02869893]		57 participants (Actual)	Interventional	2016-08-10	Completed
A Phase II Study to Establish the Efficacy of Synthetic Human SecretiN in Human Acute Pancreatitis (SNAP) Study[NCT03686618]	Phase 2	40 participants (Anticipated)	Interventional	2018-10-01	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Healthy controls underwent 3D MRE on a 1.5T scanner. Regions of interest for measurement of pancreatic stiffness were drawn by two blinded readers and statistical analysis were performed for comparisons between the 2 groups. (NCT02869893)
Timeframe: Single time point, pre-secretin

Total Secreted Fluid Volume as Measured by MR-PFT

Intervention	kPa (Mean)
Healthy Participants	1.7

"Participants underwent MR imaging prior to and following secretin administration. Pre-secretin imaging lasts approximately 20 minutes. Post-secretin images were acquired at 1 minute, 5 minutes and 15 minutes following completion of secretin injection. Pre-secretin enteric fluid volumes were subtracted from post-secretin enteric fluid volumes for each participant to determine volume secreted in response to secretin administration at each time point.~A commercially available software package determines the area of fluid signal on the MR images. The fluid signal from the pre-secretin images is then subtracted from the each post-secretin image (1, 5 and 15 minutes images) to determine the amount of fluid produced by the introduction of secretin." (NCT02869893)
Timeframe: 35 minutes (20 min pre-secretin, 15 minutes post-secretin)

Volumetric Measurement of Pancreatic Parenchymal Volume

Intervention	mL (Median)
Healthy Participants	79

Pancreatic parenchymal volume by manual segmentation (tracing) of pancreas contours on magnetic resonance imaging (MRI) (NCT02869893)
Timeframe: Single time point, pre-secretin

Article	Year
Pancreatic Dysfunction and Duodenal Inflammatory Responses Coordinate with Refractory Epigastric Pain Including Functional Dyspepsia: A Narrative Review. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2022, Jun-28, Volume: 89, Issue:3 Topics: Bicarbonates; Duodenum; Dyspepsia; Humans; Inflammation; Pain; Pancreatitis, Chronic	2022
Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis. PloS one, 2022, Volume: 17, Issue:10 Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Human	2022
[Latest advances in chronic pancreatitis]. Gastroenterologia y hepatologia, 2015, Volume: 38 Suppl 1 Topics: Autoimmune Diseases; Bicarbonates; Early Diagnosis; Elasticity Imaging Techniques; Endoscopic Ultras	2015

Article	Year
Pancreatic Elastography Predicts Endoscopic Secretin-Pancreatic Function Test Result in Patients With Early Changes of Chronic Pancreatitis: A Prospective, Cross-Sectional, Observational Study. The American journal of gastroenterology, 2022, 08-01, Volume: 117, Issue:8 Topics: Bicarbonates; Cross-Sectional Studies; Elasticity Imaging Techniques; Endosonography; Fibrosis; Huma	2022
Endoscopic ultrasound-based multimodal evaluation of the pancreas in patients with suspected early chronic pancreatitis. United European gastroenterology journal, 2020, Volume: 8, Issue:7 Topics: Adolescent; Adult; Aged; Bicarbonates; Cross-Sectional Studies; Early Diagnosis; Elasticity Imaging	2020
A study of the clinical utility of a 20-minute secretin-stimulated endoscopic pancreas function test and performance according to clinical variables. Gastrointestinal endoscopy, 2017, Volume: 86, Issue:6 Topics: Adult; Age Factors; Bicarbonates; Body Mass Index; Cholangiopancreatography, Endoscopic Retrograde;	2017
The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing: Results of a 20-Year Study. Pancreas, 2017, Volume: 46, Issue:7 Topics: Administration, Intravenous; Adult; Bicarbonates; Body Fluids; Duodenum; Female; Gastrointestinal Ag	2017
Quantification of pancreatic function using a clinically feasible short endoscopic secretin test. Pancreas, 2013, Volume: 42, Issue:7 Topics: Adult; Aged; Bicarbonates; Case-Control Studies; Endoscopy, Digestive System; Feces; Female; Humans;	2013
Diagnostic accuracy of secretin-stimulated ultrasonography of the pancreas assessing exocrine pancreatic failure in cystic fibrosis and chronic pancreatitis. Scandinavian journal of gastroenterology, 2015, Volume: 50, Issue:5 Topics: Adolescent; Adult; Aged; Bicarbonates; Case-Control Studies; Cystic Fibrosis; Duodenum; Exocrine Pan	2015
Evaluation of Qualitative Magnetic Resonance Imaging Features for Diagnosis of Chronic Pancreatitis. Pancreas, 2015, Volume: 44, Issue:8 Topics: Adolescent; Adult; Aged; Bicarbonates; Cohort Studies; Endoscopy; Female; Humans; Magnetic Resonance	2015
Detection of exocrine dysfunction by MRI in patients with early chronic pancreatitis. Abdominal radiology (New York), 2017, Volume: 42, Issue:2 Topics: Adult; Aged; Bicarbonates; Cholangiopancreatography, Magnetic Resonance; Female; Humans; Male; Middl	2017
A rapid, endoscopic exocrine pancreatic function test and the Lundh test: a comparative study. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2008, Volume: 8, Issue:6 Topics: Adult; Aged; Bicarbonates; Duodenoscopes; Duodenum; Female; Humans; Lipase; Male; Middle Aged; Pancr	2008
Evaluation of duct-cell and acinar-cell function and endosonographic abnormalities in patients with suspected chronic pancreatitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009, Volume: 7, Issue:1 Topics: Adult; Aged; Bicarbonates; Cholecystokinin; Endoscopy, Digestive System; Endosonography; Female; Hum	2009
Combined endoscopic ultrasound and secretin endoscopic pancreatic function test in patients evaluated for chronic pancreatitis. Digestive diseases and sciences, 2010, Volume: 55, Issue:9 Topics: Adult; Bicarbonates; Duodenoscopy; Duodenum; Endosonography; Feasibility Studies; Female; Humans; In	2010
Magnetic resonance cholangiopancreatography reports in the evaluation of chronic pancreatitis: a need for quality improvement. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2009, Volume: 9, Issue:6 Topics: Adult; Bicarbonates; Cholangiopancreatography, Magnetic Resonance; Cross-Sectional Studies; Endoscop	2009
Comparison of autoanalyzer and back titration for measurement of bicarbonate concentration in endoscopically collected pancreatic fluid. Pancreas, 2011, Volume: 40, Issue:2 Topics: Autoanalysis; Bicarbonates; Endoscopy; Endosonography; Humans; Ohio; Pancreatic Function Tests; Panc	2011
Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis. Gastroenterology, 2011, Volume: 140, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Base Sequence; Bicarbonates; Carrier Proteins; Child; Ch	2011
An automated analyzer provides clinically concordant results to manual back titration for quantitation of bicarbonate in pancreatic juice. Pancreas, 2011, Volume: 40, Issue:3 Topics: Adult; Autoanalysis; Bicarbonates; Exocrine Pancreatic Insufficiency; Female; Humans; Male; Middle A	2011
Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers. Gastroenterology, 2011, Volume: 141, Issue:6 Topics: Animals; Anion Exchange Resins; Bicarbonates; Cystic Fibrosis Transmembrane Conductance Regulator; E	2011
Pancreatic duct compliance after secretin stimulation: a novel endoscopic ultrasound diagnostic tool for chronic pancreatitis. Pancreas, 2012, Volume: 41, Issue:2 Topics: Adult; Bicarbonates; Chi-Square Distribution; Compliance; Duodenum; Endosonography; Feasibility Stud	2012
Abnormal duodenal [HCO3-] following secretin stimulation develops sooner than endocrine insufficiency in minimal change chronic pancreatitis. Pancreas, 2012, Volume: 41, Issue:3 Topics: Adult; Bicarbonates; Chi-Square Distribution; Disease Progression; Duodenum; Endosonography; Exocrin	2012
Endoscopic pancreatic function test using combined secretin and cholecystokinin stimulation for the evaluation of chronic pancreatitis. Gastrointestinal endoscopy, 2012, Volume: 75, Issue:4 Topics: Acinar Cells; Adult; Amylases; Area Under Curve; Bicarbonates; Chi-Square Distribution; Cholecystoki	2012
The significance of the volume of pancreatic juice measured at secretin stimulation testing: a single-center evaluation of 224 classical secretin stimulation tests. Pancreas, 2012, Volume: 41, Issue:7 Topics: Adult; Bicarbonates; Female; Humans; Male; Middle Aged; Pancreatic Juice; Pancreatitis, Chronic; Ret	2012
Cigarette smoking impairs pancreatic duct cell bicarbonate secretion. JOP : Journal of the pancreas, 2013, Jan-10, Volume: 14, Issue:1 Topics: Adult; Alcohol Drinking; Bicarbonates; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; M	2013
[ROENTGEN DIAGNOSTIC FINDINGS, ENZYME DISTURBANCE, EXRETORY AND INTERNAL SECRETORY FUNCTION DISORDER OF THE PANCREAS IN CHRONIC PANCREATITIS]. Gastroenterologia, 1964, Volume: 101 Topics: Amylases; Bicarbonates; Clinical Enzyme Tests; Enzymes; Glycogen; Humans; Hydrolases; Lipase; Pancre	1964
Dissociation of secretion of pancreatic enzymes and bicarbonate in patients with chronic pancreatitis. Gastroenterology, 1950, Volume: 15, Issue:2 Topics: Bicarbonates; Humans; Pancreas; Pancreatitis; Pancreatitis, Chronic	1950
Duodenal acidity may increase the risk of pancreatic cancer in the course of chronic pancreatitis: an etiopathogenetic hypothesis. JOP : Journal of the pancreas, 2005, Mar-10, Volume: 6, Issue:2 Topics: Alcohol Drinking; Bicarbonates; Duodenum; Exocrine Pancreatic Insufficiency; Gastric Acid; Humans; H	2005
Where have all the dreiling tubes gone? The American journal of gastroenterology, 2006, Volume: 101, Issue:2 Topics: Bicarbonates; Humans; Intestinal Secretions; Intubation, Gastrointestinal; Pancreas; Pancreatic Func	2006
Evaluation of pancreatic endocrine and exocrine function in patients with autoimmune pancreatitis. Pancreas, 2007, Volume: 34, Issue:2 Topics: Adult; Aged; Autoimmune Diseases; Bicarbonates; Constriction, Pathologic; Diabetes Mellitus; Female;	2007
Comparison of endoscopic ultrasound chronic pancreatitis criteria to the endoscopic secretin-stimulated pancreatic function test. Digestive diseases and sciences, 2007, Volume: 52, Issue:5 Topics: Adult; Bicarbonates; Cross-Sectional Studies; Duodenoscopy; Duodenum; Endosonography; Female; Humans	2007

hydrogen carbonate and Pancreatitis, Chronic