hydrogen carbonate and Pancreatic Neoplasms studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Research Excerpts

Excerpt	Relevance	Reference
"A patient with severe watery diarrhea and a non-beta islet cell carcinoma of the pancreas producing five hormones (secretin, serotonin, enteroglucagon, vasoactive intestinal polypeptide, and pancreatic glucagon) is described."	3.65	Watery diarrhea associated with pancreatic islet cell carcinoma. ( Chey, WY; Hensley, GT; Schmitt, MG; Soergel, KH, 1975)
" The present results encourage a new study to be undertaken in a larger sample and with a multiple dosing scheme of treatment."	2.70	Evaluation of lanreotide effects on human exocrine pancreatic secretion after a single dose: preliminary study. ( Ballabio, M; Bassi, C; Contro, C; Falconi, M; Pederzoli, P; Salvia, R, 2002)
"In the United States, pancreatic cancer is the fourth most frequent cause of cancer death in males as well as females, after lung, prostate or breast, and colorectal cancer."	2.42	Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. ( Risch, HA, 2003)
"Melatonin was found to improve pancreatic organ function in diseased animals."	1.33	Melatonin modulates acid/base transport in human pancreatic carcinoma cells. ( Aust, S; Brucker, B; Graf, J; Klimpfinger, M; Thalhammer, T, 2006)
"Forty-five patients (17 with pancreatic cancer, 6 pancreatitis, 5 other malignancies, and 17 nonmalignant, nonpancreatic disease found at laparotomy) were studied with a method of duodenal intubation and perfusion with basal saline perfusion alone or with continuous intravenous infusion of secretin or of cholecystokinin-pancreozymin."	1.26	The relationships between pancreatic ductal obstruction and pancreatic secretion in man. ( DiMagno, EP; Go, VL; Malagelada, JR, 1979)
"For detection of pancreatic cancer, enzyme and bicarbonate outputs in response to CCK are more accurate than pancreatic CEA or bicarbonate outputs in response to secretin."	1.26	Prospective evaluation of the pancreatic secretion of immunoreactive carcinoembryonic antigen, enzyme, and bicarbonate in patients suspected of having pancreatic cancer. ( DiMagno, EP; Go, VL; Malagelada, JR; Moertel, CG, 1977)
"Thus, there is fixation of flow in pancreatic cancer and fixation of bicarbonate in pancreatic inflammation."	1.25	Secretion analysis: secretin testing in pancreatic cancer. ( Dreiling, DA, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	56 (77.78)	18.7374
1990's	4 (5.56)	18.2507
2000's	7 (9.72)	29.6817
2010's	1 (1.39)	24.3611
2020's	4 (5.56)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pancreatic Enzyme Replacement Therapy (PERT) for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer[NCT02985801]			Phase 1/Phase 2	16 participants (Actual)	Interventional	2016-12-31	Terminated (stopped due to Study was terminated due to difficulty in recruiting subjects.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. Journal of the National Cancer Institute, 2003, Jul-02, Volume: 95, Issue:13 Topics: Animals; Anticarcinogenic Agents; Bicarbonates; Carotenoids; Diabetes Complications; Duodenal Ulcer;	2003
Vasoactive intestinal polypeptide. Clinics in gastroenterology, 1980, Volume: 9, Issue:3 Topics: Acute Kidney Injury; Adenoma, Islet Cell; Animals; Bicarbonates; Brain; Dehydration; Digestive Syste	1980
Tests of exocrine pancreatic function. Annals of clinical biochemistry, 1977, Volume: 14, Issue:2 Topics: Amylases; Bicarbonates; Biliary Tract Diseases; Carbohydrate Metabolism; Child; Cholecystokinin; Chy	1977
The secretin story: a saga in clinical medicine and gastrointestinal physiology. The American journal of gastroenterology, 1978, Volume: 70, Issue:5 Topics: Amylases; Animals; Bicarbonates; Cholestasis; Digestive System Physiological Phenomena; Gastrointest	1978

Article	Year
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Animals; Bicarbonates; Carcinoma, Pancreatic Ductal; Immune Tolerance; Immunotherapy; Mice; Pancreat	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Bicarbonate transport as a vulnerability in pancreatic cancer. Nature cancer, 2022, Volume: 3, Issue:12 Topics: Bicarbonates; Humans; Ion Transport; Pancreas; Pancreatic Juice; Pancreatic Neoplasms	2022
Synergistic effects of agonists and two-pore-domain potassium channels on secretory responses of human pancreatic duct cells Capan-1. Pflugers Archiv : European journal of physiology, 2023, Volume: 475, Issue:3 Topics: Adenocarcinoma; Adenosine Triphosphatases; Bicarbonates; Epithelial Cells; Humans; Pancreatic Ducts;	2023
Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer. Molecular oncology, 2023, Volume: 17, Issue:4 Topics: Bicarbonates; Carcinoma, Pancreatic Ductal; Humans; Immune Tolerance; Immunotherapy; Pancreatic Neop	2023
Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer. Molecular oncology, 2023, Volume: 17, Issue:4 Topics: Bicarbonates; Carcinoma, Pancreatic Ductal; Humans; Immune Tolerance; Immunotherapy; Pancreatic Neop	2023
Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer. Molecular oncology, 2023, Volume: 17, Issue:4 Topics: Bicarbonates; Carcinoma, Pancreatic Ductal; Humans; Immune Tolerance; Immunotherapy; Pancreatic Neop	2023
Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer. Molecular oncology, 2023, Volume: 17, Issue:4 Topics: Bicarbonates; Carcinoma, Pancreatic Ductal; Humans; Immune Tolerance; Immunotherapy; Pancreatic Neop	2023
Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone. Annals of surgery, 2017, Volume: 266, Issue:2 Topics: Adult; Bicarbonates; Body Water; Female; Humans; Immunohistochemistry; Intestinal Mucosa; Intestine,	2017
CFTR expression but not Cl- transport is involved in the stimulatory effect of bile acids on apical Cl-/HCO3- exchange activity in human pancreatic duct cells. Pancreas, 2009, Volume: 38, Issue:8 Topics: Animals; Bicarbonates; Biological Transport; Calcium; Calcium Signaling; Carcinoma, Pancreatic Ducta	2009
Targeting of carbonic anhydrase IV to plasma membranes is altered in cultured human pancreatic duct cells expressing a mutated (deltaF508) CFTR. European journal of cell biology, 2002, Volume: 81, Issue:8 Topics: Actins; Adult; Bicarbonates; Carbonic Anhydrase IV; Carcinoma; Cell Division; Cell Membrane; Cell Po	2002
[STUDY OF THE EXOCRINE FUNCTION OF THE PANCREAS WITH SECRETIN AND PANCREOZYMIN]. Jornal do medico, 1963, Nov-22, Volume: 52 Topics: Amylases; Bicarbonates; Cholecystokinin; Cystic Fibrosis; Diarrhea; Gastrointestinal Hormones; Hemoc	1963
[STUDY OF THE EXOCRINE FUNCTION OF THE PANCREAS WITH SECRETIN AND PANCREOZYMIN]. Jornal do medico, 1963, Nov-23, Volume: 52 Topics: Amylases; Bicarbonates; Cholecystokinin; Cystic Fibrosis; Diarrhea; Gastrointestinal Hormones; Hemoc	1963
[AN EXPLORATION OF THE EXOCRINE FUNCTION OF THE PANCREAS WITH SECRETIN AND PANCREOZYMIN]. Revista espanola de las enfermedades del aparato digestivo y de la nutricion, 1963, Volume: 22 Topics: Amylases; Bicarbonates; Cholecystokinin; Diarrhea; Gastrointestinal Hormones; Hemochromatosis; Human	1963
SECRETIN TESTS OF PANCREATIC AND BILIARY TRACT DISEASE. Archives of internal medicine, 1964, Volume: 114 Topics: Bicarbonates; Bile Duct Neoplasms; Biliary Tract; Biliary Tract Diseases; Biomedical Research; Cell	1964
[EXAMINATION OF THE FUNCTION OF THE EXOCRINE PANCREAS. VALUE OF THE MAXIMUM CONCENTRATION OF BICARBONATES AND OF THE VOLUME MEASUREMENTS UNDER STIMULATION WITH PURIFIED SECRETIN]. Helvetica medica acta, 1964, Volume: 31 Topics: Bicarbonates; Bodily Secretions; Diagnosis; Gastrointestinal Hormones; Humans; Pancreas, Exocrine; P	1964
Rapid endoscopic secretin stimulation test and discrimination of chronic pancreatitis and pancreatic cancer from disease controls. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:5 Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Bicarbonates; Cholecystokinin; Chronic D	2003
Duodenal acidity may increase the risk of pancreatic cancer in the course of chronic pancreatitis: an etiopathogenetic hypothesis. JOP : Journal of the pancreas, 2005, Mar-10, Volume: 6, Issue:2 Topics: Alcohol Drinking; Bicarbonates; Duodenum; Exocrine Pancreatic Insufficiency; Gastric Acid; Humans; H	2005
Melatonin modulates acid/base transport in human pancreatic carcinoma cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2006, Volume: 18, Issue:1-3 Topics: Acids; Antiporters; Bicarbonates; Biological Transport; Cell Line, Tumor; Colforsin; Cyclic AMP; Gen	2006
The output of protein after pancreozymin. A test of pancreatic function. Annals of internal medicine, 1967, Volume: 66, Issue:4 Topics: Bicarbonates; Cholecystokinin; Duodenum; Humans; Pancreatic Juice; Pancreatic Neoplasms; Pancreatiti	1967
[Evaluation of the exocrine function of the pancreas with the secretin test]. Minerva medica, 1967, Oct-20, Volume: 58, Issue:84 Topics: Bicarbonates; Candidiasis; Cholelithiasis; Colitis, Ulcerative; Diabetes Mellitus; Humans; Malabsorp	1967
Parotid salivary secretion in pancreatic disease. Australian and New Zealand journal of medicine, 1981, Volume: 11, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Amylases; Bicarbonates; Carcinoma; Chronic Disease; Humans;	1981
[Secretin test and its applications]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1984, Volume: 6, Issue:5 Topics: Bicarbonates; Humans; Pancreatic Function Tests; Pancreatic Juice; Pancreatic Neoplasms; Pancreatiti	1984
Diagnosis of pancreatic disease with special reference to the secretin-CCK test. Scandinavian journal of gastroenterology. Supplement, 1980, Volume: 60 Topics: Adult; Aged; Bicarbonates; Carcinoembryonic Antigen; Cholangiography; Cholecystokinin; Duodenum; Fem	1980
The intraductal secretin test: an adjunct to ERCP. Gastrointestinal endoscopy, 1982, Volume: 28, Issue:3 Topics: Bicarbonates; Cholangiopancreatography, Endoscopic Retrograde; Cholecystokinin; Diagnosis, Different	1982
Hypotonic duodenography and secretin-CCK test in the diagnosis of pancreatic disease. Acta radiologica: diagnosis, 1981, Volume: 22, Issue:1 Topics: Adult; Aged; Bicarbonates; Cholecystokinin; Duodenum; Female; Humans; Male; Middle Aged; Pancreatic	1981
The expression of carbonic anhydrases II and IV in the human pancreatic cancer cell line (Capan 1) is associated with bicarbonate ion channels. Biology of the cell, 1994, Volume: 81, Issue:2 Topics: Acetazolamide; Bicarbonates; Carbonic Anhydrases; Cell Division; Humans; Immunohistochemistry; Ion C	1994
Adenylate cyclase activity in human pancreatic adenocarcinoma cell lines. International journal of pancreatology : official journal of the International Association of Pancreatology, 1996, Volume: 19, Issue:1 Topics: Adenocarcinoma; Adenylyl Cyclases; Adrenergic beta-Agonists; Bicarbonates; Colforsin; Dopamine; Huma	1996
[The treatment of pancreatic carcinoma with neocarzinostatin]. Nihon Gan Chiryo Gakkai shi, 1975, Dec-20, Volume: 10, Issue:4 Topics: Aged; Amylases; Animals; Antibiotics, Antineoplastic; Bicarbonates; Humans; Middle Aged; Pancreatic	1975
Watery diarrhea associated with pancreatic islet cell carcinoma. Gastroenterology, 1975, Volume: 69, Issue:1 Topics: Adenoma, Islet Cell; Animals; Autopsy; Bicarbonates; Cats; Diarrhea; Duodenum; Epithelium; Feces; Ga	1975
The relationships between pancreatic ductal obstruction and pancreatic secretion in man. Mayo Clinic proceedings, 1979, Volume: 54, Issue:3 Topics: Adult; Bicarbonates; Humans; Lipase; Pancreas; Pancreatic Diseases; Pancreatic Ducts; Pancreatic Neo	1979
Bicarbonate output for detection of pancreatic cancer. Gastroenterology, 1979, Volume: 76, Issue:5 Pt 1 Topics: Bicarbonates; Humans; Pancreas; Pancreatic Neoplasms	1979
Clinical studies on human pancreatic deoxyribonuclease I. Gastroenterologia Japonica, 1979, Volume: 14, Issue:1 Topics: Amylases; Bicarbonates; Chronic Disease; Deoxyribonucleases; Duodenum; Humans; Pancreas; Pancreatic	1979
Parotid salivary gland function in patients with exocrine pancreatic insufficiency. Acta hepato-gastroenterologica, 1979, Volume: 26, Issue:5 Topics: Bicarbonates; Chronic Disease; Humans; Pancreatic Diseases; Pancreatic Function Tests; Pancreatic Ju	1979
The place of duodenal drainage studies in the diagnosis of pancreatic disease. Surgery, 1978, Volume: 84, Issue:4 Topics: Bicarbonates; Carcinoembryonic Antigen; Cholelithiasis; Chronic Disease; Drainage; Duodenum; Humans;	1978
A comparative evaluation of endoscopic retrograde pancreatography and secretin-CCK test in the diagnosis of pancreatic disease. Scandinavian journal of gastroenterology, 1978, Volume: 13, Issue:7 Topics: Adult; Aged; Bicarbonates; Cholecystokinin; Endoscopy; Evaluation Studies as Topic; Humans; Middle A	1978
The secretin-CCK test and a modified Lundh test. A comparative study. Scandinavian journal of gastroenterology, 1978, Volume: 13, Issue:8 Topics: Adult; Aged; Bicarbonates; Cholecystokinin; Duodenum; Food; Gastrointestinal Diseases; Humans; Intub	1978
Analysis of human pure pancreatic juice in chronic pancreatitis and cancer of the pancreas. Gastroenterologia Japonica, 1978, Volume: 13, Issue:6 Topics: Adult; Aged; Amylases; Bicarbonates; Chronic Disease; Chymotrypsinogen; Female; Humans; Lipase; Male	1978
Prospective evaluation of the pancreatic secretion of immunoreactive carcinoembryonic antigen, enzyme, and bicarbonate in patients suspected of having pancreatic cancer. Gastroenterology, 1977, Volume: 73, Issue:3 Topics: Adult; Bicarbonates; Carcinoembryonic Antigen; Cholecystokinin; Humans; Jaundice; Lipase; Pancreas;	1977
Alcoholism, alcoholic pancreatitis, and pancreatic secretion. Annals of the New York Academy of Sciences, 1975, Apr-25, Volume: 252 Topics: Alcoholism; Amylases; Bicarbonates; Calcinosis; Chronic Disease; Humans; Pancreas; Pancreatic Neopla	1975
Pancreatic secretion in pernicious anemia. The American journal of gastroenterology, 1975, Volume: 63, Issue:6 Topics: Alcoholism; Amylases; Anemia, Pernicious; Atrophy; Bicarbonates; Gastrins; Gastritis; Humans; Pancre	1975
Secretion analysis: secretin testing in pancreatic cancer. Journal of surgical oncology, 1975, Volume: 7, Issue:2 Topics: Amylases; Bicarbonates; Chronic Disease; Diagnostic Errors; Pancreas; Pancreatic Neoplasms; Pancreat	1975
Pancreatic secretory testing in 1974. Gut, 1975, Volume: 16, Issue:8 Topics: Bicarbonates; Chronic Disease; Costs and Cost Analysis; Diagnosis, Differential; Humans; Pancreas; P	1975
Na+/H+ exchange is responsible for intracellular pH regulation in insulin-secreting HIT-T15 cells. Molecular and cellular endocrinology, 1990, May-28, Volume: 71, Issue:1 Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo	1990
[Study of disorders of the exocrine function of the pancreas in various pancreatic diseases based on complex examination]. Klinicheskaia meditsina, 1990, Volume: 68, Issue:5 Topics: Adult; Aged; Bicarbonates; Chronic Disease; Female; Humans; Lipase; Male; Middle Aged; Pancreas; Pan	1990
[Secretory pattern of the pancreas in chronic pancreatitis]. Zeitschrift fur Gastroenterologie, 1989, Volume: 27 Suppl 3 Topics: Amylases; Bicarbonates; Chronic Disease; Humans; Lipase; Pancreas; Pancreatic Function Tests; Pancre	1989
Pancreatic carcinogenesis: effect of secretin in the hamster- nitrosamine model. Journal of the National Cancer Institute, 1987, Volume: 78, Issue:1 Topics: Adenocarcinoma; Animals; Bicarbonates; Cricetinae; Drug Synergism; Infusions, Intravenous; Injection	1987
Pancreatic tumor with intractable watery diarrhea, hypokalemia and hypercalcemia electrolyte balance studies. Scandinavian journal of gastroenterology, 1967, Volume: 2, Issue:4 Topics: Adenoma, Islet Cell; Alkaline Phosphatase; Bicarbonates; Calcium; Creatinine; Diarrhea; Humans; Hype	1967
Bio-assay evidence of abnormal secretin-like and gastrin-like activity in tumour and blood in cases of "choleraic diarrhoea". Gut, 1970, Volume: 11, Issue:3 Topics: Adenoma, Islet Cell; Animals; Bicarbonates; Biological Assay; Cats; Diarrhea; Dogs; Gastrins; Humans	1970
Pancreatic islet cell tumour with watery diarrhoea and hypokalaemia. Gut, 1970, Volume: 11, Issue:11 Topics: Adenoma, Islet Cell; Bicarbonates; Chlorides; Diarrhea; Feces; Female; Hematocrit; Humans; Hypokalem	1970
Watery diarrhea and hypokalemia due to nonbeta-islet cell hyperplasia of the pancreas. The American journal of gastroenterology, 1972, Volume: 57, Issue:4 Topics: Adenoma, Islet Cell; Bicarbonates; Celiac Disease; Diarrhea; Duodenum; Feces; Female; Gastric Juice;	1972
Ulcer disease, metabolic alkalosis and hyperparathyroidism: A mechanism of interrelationship? Annals of surgery, 1974, Volume: 180, Issue:4 Topics: Adult; Aged; Alkalosis; Bicarbonates; Calcium; Female; Gastric Juice; Gastrins; Humans; Hypercalcemi	1974
[Experiences in the biochemical diagnosis of the pancreatic diseases]. Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1974, Volume: 34, Issue:2-4 Topics: Amylases; Bicarbonates; Bile Pigments; Blood Glucose; Blood Protein Electrophoresis; Chymotrypsin; D	1974
Alimentary hypoglycemia associated with the Zollinger-Ellison syndrome. The American journal of medicine, 1973, Volume: 54, Issue:5 Topics: Adult; Bicarbonates; Biopsy; Blood Glucose; Duodenum; Female; Humans; Hyperparathyroidism; Hypoglyce	1973
An evaluation of 75 Se selenomethionine scanning as a test of pancreatic function compared with the secretin-pancreozymin test. Gut, 1973, Volume: 14, Issue:5 Topics: Bicarbonates; Celiac Disease; Cholecystokinin; Chronic Disease; Humans; Jaundice; Liver Cirrhosis; L	1973
Pancreatic exocrine function in maturity onset diabetes mellitus. British medical journal, 1973, Oct-06, Volume: 4, Issue:5883 Topics: Adult; Aged; Amylases; Bicarbonates; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Fatty	1973
Maximum bicarbonate response to intravenous infusion of 'GIH' secretin in man. Clinical science and molecular medicine, 1973, Volume: 45, Issue:6 Topics: Bicarbonates; Duodenum; Humans; Inhalation; Intubation, Gastrointestinal; Pancreas; Pancreatic Neopl	1973
[Diagnostic value of measurement of pancreatic function after stimulation with cholecystokinin-pancreozymin, secretin and bile (author's transl)]. Klinische Wochenschrift, 1973, Sep-15, Volume: 51, Issue:18 Topics: Amylases; Bicarbonates; Bile Acids and Salts; Bilirubin; Carcinoma; Cholecystokinin; Chronic Disease	1973
Simultaneous combined pancreatic test. British medical journal, 1974, Jan-19, Volume: 1, Issue:5898 Topics: Acute Disease; Bicarbonates; Chronic Disease; Diagnosis, Differential; Drainage; Duodenum; Humans; I	1974
Necrolytic migratory erythema with carcinoma of pancreas. Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:1 Topics: Aged; Bicarbonates; Body Weight; Cholecystokinin; Eczema; Erythema; Female; Humans; Pancreatic Neopl	1974
[Pancreatic intubation and scanning. Comparative study]. La Nouvelle presse medicale, 1974, Mar-23, Volume: 3, Issue:12 Topics: Bicarbonates; Exocrine Glands; Female; Humans; Intubation, Gastrointestinal; Lipase; Male; Pancreas;	1974
[The secretin-pancreozymin test in the diagnosis of pancreatic insufficiency]. Der Internist, 1970, Volume: 11, Issue:3 Topics: Adult; Bicarbonates; Cholecystokinin; Endopeptidases; Female; Humans; Lipase; Male; Middle Aged; Pan	1970
An evaluation of the secretin test in chronic pancreatic disease. The Medical journal of Australia, 1972, Apr-22, Volume: 1, Issue:17 Topics: Bicarbonates; Chronic Disease; Cytodiagnosis; Duodenum; Evaluation Studies as Topic; Humans; Hydroge	1972
An appraisal of 75 Se-selenomethionine scanning as a test of pancreatic function: a comparison with the secretin-pancreozymin test. Gut, 1972, Volume: 13, Issue:10 Topics: Amylases; Bicarbonates; Cholecystokinin; Humans; Methionine; Pancreas; Pancreatic Neoplasms; Pancrea	1972
Pancreatic extracts. British medical journal, 1970, Apr-18, Volume: 2, Issue:5702 Topics: Adult; Aged; Bicarbonates; Bile Acids and Salts; Cystic Fibrosis; Humans; Infant; Lipase; Malabsorpt	1970
[Value of secretin test in the diagnosis of pancreatic diseases]. Lyon medical, 1970, Mar-29, Volume: 223, Issue:13 Topics: Adolescent; Adult; Aged; Bicarbonates; Humans; Middle Aged; Pancreatic Diseases; Pancreatic Neoplasm	1970
Tests of pancreatic function. Proceedings of the Royal Society of Medicine, 1970, Volume: 63, Issue:5 Topics: Bicarbonates; Cholecystokinin; Duodenum; Humans; Pancreas; Pancreatic Diseases; Pancreatic Neoplasms	1970
Bicarbonate and acid secretion in the diagnosis of pancreatic disease. Scandinavian journal of gastroenterology, 1970, Volume: 5, Issue:6 Topics: Adolescent; Adult; Aged; Bicarbonates; Duodenum; Female; Gastric Acidity Determination; Gastric Juic	1970
Tests of pancreatic function. The British journal of clinical practice, 1970, Volume: 24, Issue:7 Topics: Bicarbonates; Humans; Methods; Pancreas; Pancreatic Diseases; Pancreatic Neoplasms; Pancreatitis; Tr	1970
Clinical correlations with pancreatic function tests. Canadian Medical Association journal, 1968, Jan-27, Volume: 98, Issue:4 Topics: Adolescent; Adult; Aged; Amylases; Bicarbonates; Bile Duct Neoplasms; Biliary Tract Diseases; Biliru	1968
[Metabolic studies in a clinical case after total pancreatectomy]. Wiener klinische Wochenschrift, 1968, Nov-01, Volume: 80, Issue:44 Topics: Aged; Amylases; Bicarbonates; Blood Glucose; Blood Proteins; Cholecystokinin; Chymotrypsin; Diet The	1968

hydrogen carbonate and Pancreatic Neoplasms

Research Excerpts

Research

Studies (72)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Cappellesso, F	2
Orban, MP	2
Shirgaonkar, N	2
Berardi, E	2
Serneels, J	2
Neveu, MA	2
Di Molfetta, D	2
Piccapane, F	2
Caroppo, R	2
Debellis, L	2
Ostyn, T	2
Joudiou, N	2
Mignion, L	2
Richiardone, E	2
Jordan, BF	2
Gallez, B	2
Corbet, C	2
Roskams, T	2
DasGupta, R	2
Tejpar, S	2
Di Matteo, M	2
Taverna, D	2
Reshkin, SJ	2
Topal, B	2
Virga, F	2
Mazzone, M	2
Qiang, L	2
Dougan, SK	2
Sørensen, CE	1
Trauzold, A	1
Christensen, NM	1
Tawfik, D	1
Szczepanowski, M	1
Novak, I	1
Kay, EJ	1
Zanivan, S	1
Chey, WY	2
Frankel, WL	1
Roy, S	1
Datta, S	1
Sen, CK	1
Dillhoff, M	1
Muscarella, P	1
Soergel, KH	2
Tompkins, RK	1
Chang, TM	1
Bradley, EL	1
Ellison, EC	1
Ignáth, I	1
Hegyi, P	1
Venglovecz, V	1
Székely, CA	1
Carr, G	1
Hasegawa, M	1
Inoue, M	1
Takács, T	1
Argent, BE	2
Gray, MA	1
Rakonczay, Z	1
Fanjul, M	1
Salvador, C	1
Alvarez, L	1
Cantet, S	1
Hollande, E	2
Risch, HA	1
CORREIA, JP	2
BARROS, F	3
PINTOCORREIA, J	1
GOLDSTEIN, F	1
WIRTS, CW	1
COZZOLINO, HJ	1
MENDUKE, H	1
PERRIER, CV	1
DESBAILLETS, LG	1
DUCKERT, A	1
PERRIER, C	1
Raimondo, M	1
Imoto, M	1
DiMagno, EP	3
Talamini, G	1
Aust, S	1
Brucker, B	1
Graf, J	1
Klimpfinger, M	1
Thalhammer, T	1
Hanscom, DH	1
Jacobson, BM	1
Littman, A	1
Bertero, R	1
Saracco, C	1
Bruno, G	1
De la Pierre, M	1
Fahrenkrug, J	1
Slavotinek, AH	1
Frissell, AE	1
Deakin, EJ	1
Elmslie, RG	1
Lu, XH	1
Chen, MZ	1
Bi, ZH	1
Lu, GJ	1
Fan, J	1
Wen, SH	1
Rolny, P	4
Gregg, JA	1
Lukes, PJ	2
Nilson, AE	1
Gamklou, R	2
Mahieu, I	1
Becq, F	1
Wolfensberger, T	1
Gola, M	1
Carter, N	1
al-Nakkash, L	1
Simmons, NL	1
Lingard, JM	1
Falconi, M	1
Contro, C	1
Ballabio, M	1
Bassi, C	1
Salvia, R	1
Pederzoli, P	1
Kinami, Y	1
Miyazaki, H	1
Koyama, F	1
Noguchi, M	1
Konishi, K	1
Schmitt, MG	1
Hensley, GT	1
Gowenlock, AH	1
Dreiling, DA	5
Messer, J	1
Malagelada, JR	2
Go, VL	2
Gullo, L	1
Funakoshi, A	1
Tsubota, Y	1
Wakasugi, H	1
Ibayashi, H	1
Takagi, Y	1
McColl, KE	1
Brodie, MJ	1
Whitesmith, R	1
Gray, KF	1
Thomson, TJ	1
Cooper, MJ	1
Moossa, DE	1
Cockerham, L	1
Hall, TJ	1
Levin, B	1
Moossa, AR	1
Jagenburg, R	2
Nilson, A	1
Harada, H	1
Hayashi, T	1
Ono, A	1
Yamamoto, N	1
Ikubo, I	1
Shundo, T	1
Negron, A	1
Mishima, K	1
Kimura, I	1
Moertel, CG	1
Greenstein, AJ	1
Trebilcock, R	1
Lynch, A	1
Tomlinson, S	1
Best, L	1
Timoshenko, GD	1
Otte, M	2
Thurmayr, GR	1
Thurmayr, R	1
Howatson, AG	1
Carter, DC	1
Kofstad, J	1
Froyshov, I	1
Gjone, E	1
Blix, S	1
Cleator, IG	1
Thomson, CG	1
Sircus, W	1
Coombes, M	1
Stoker, DJ	1
Wynn, V	1
Jacobs, WH	1
Halperin, P	1
Mantz, FA	1
Kaplan, EL	1
Peskin, GW	1
Deveney, C	1
Way, L	1
Jaffe, B	1
Friĕ, P	1
O'Brien, TK	1
Tijtgat, G	1
Ensinck, JW	1
Braganza, J	2
Critchley, M	2
Howat, HT	2
Testa, HJ	2
Torrance, HB	2
Baron, JH	3
Nabarro, JD	1
Gutierrez, LV	1
Stahlheber, H	1
Lehnert, P	1
Forell, MM	1
Nundy, S	1
Shirley, D	1
Beales, JS	1
O'Higgins, N	1
Heaf, R	1
Pearse, EE	1
Lavender, JP	1
Warin, AP	1
Quinton, A	1
Tamarelle, C	1
Dubarry, JJ	1
Blanquet, P	1
Rick, W	1
Thomas, E	1
Hackett, E	1
O'Halloran, MW	1
Hislop, IG	1
Grant, AK	1
Descos, L	1
Vagne, M	1
Wormsley, KG	2
Petersen, H	1
Hershfield, NB	1
Lind, JF	1
Hildes, JA	1
Brunner, E	1
Frischauf, H	1
Kühlmayer, R	1