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hydrogen carbonate and Osteomalacia

hydrogen carbonate has been researched along with Osteomalacia in 41 studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Osteomalacia: Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.

Research Excerpts

ExcerptRelevanceReference
" Furthermore they suggest that a relative native vitamin D deficiency may have a calcitriol independent role in favoring the occurrence of both osteitis fibrosa and osteomalacia."7.69[Relative depletion in native vitamin D: a potential risk factor in Algerian hemodialysis patients with radiological evidence of hyperparathyroidism and osteomalacia independent of calcitriolemia]. ( Achard, JM; Atik, A; Brazier, M; Fournier, A; Ghazali, A; Gueris, J; Leflon, P; Morinière, P; Oprisiu, R; Rida, Z; Sari, Z, 1997)
"The biochemical changes observed in a patient with adult-onset hypophosphataemic osteomalacia after three weeks treatment with 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) followed by dihydrotachysterol (DHT) are reported."7.66The response to 1,25-dihydroxycholecalciferol and to dihydrotachysterol in adult-onset hypophosphataemic osteomalacia. ( Ahmed, KY; Moorhead, JF; Varghese, Z; Wills, MR, 1979)
"This article reviews the clinical, biological, radiological, and pathological procedures and their respective indications for the practical diagnosis of the following various histological patterns of renal osteodystrophy: osteitis fibrosa due to parathyroid hormone (PTH) hypersecretion: osteomalacia or rickets due to native vitamin D deficiency and/or aluminum overload; and adynamic bone disease (ABD) due to aluminum overload and/or PTH secretion oversuppression."4.80Renal osteodystrophy in dialysis patients: diagnosis and treatment. ( Abighanem, O; Achard, JM; Atik, A; Boudailliez, B; El Esper, N; Fournier, A; Ghazali, A; Hedri, H; Hottelart, C; Moriniere, P; Oprisiu, R; Pruna, A; Rasolombololona, M; Said, S; Sarraj, A; Sechet, A; Westeel, PF; Yverneau, PH, 1998)
" Furthermore they suggest that a relative native vitamin D deficiency may have a calcitriol independent role in favoring the occurrence of both osteitis fibrosa and osteomalacia."3.69[Relative depletion in native vitamin D: a potential risk factor in Algerian hemodialysis patients with radiological evidence of hyperparathyroidism and osteomalacia independent of calcitriolemia]. ( Achard, JM; Atik, A; Brazier, M; Fournier, A; Ghazali, A; Gueris, J; Leflon, P; Morinière, P; Oprisiu, R; Rida, Z; Sari, Z, 1997)
"The biochemical changes observed in a patient with adult-onset hypophosphataemic osteomalacia after three weeks treatment with 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) followed by dihydrotachysterol (DHT) are reported."3.66The response to 1,25-dihydroxycholecalciferol and to dihydrotachysterol in adult-onset hypophosphataemic osteomalacia. ( Ahmed, KY; Moorhead, JF; Varghese, Z; Wills, MR, 1979)
"Hyperchloremic metabolic acidosis is a complication of urinary diversion using ileum or colon."2.52Bone and metabolic complications of urinary diversions. ( Cano Megías, M; Muñoz Delgado, EG, 2015)
" Very often, the chronic administration of alkali results in normal growth and development, and greatly reduces the risk of stone formation or nephrocalcinosis."2.38[Renal tubular acidosis in children]. ( Cachat, F; Froidevaux, V; Guignard, JP, 1993)
"The development of renal tubular acidosis in this condition further impairs renal function and we suggest that correction of systemic acidosis might improve renal function and prevent further decline in these patients."2.38Renal failure in adult onset hypophosphatemic osteomalacia with Fanconi syndrome: a family study and review of the literature. ( Bateman, JM; Harrison, NA; Ledingham, JG; Smith, R, 1991)
"Familial distal renal tubular acidosis (dRTA) associated with mutations of solute carrier family 4 membrane - 1 (SLC4A1) gene could co-exist with red cell membrane abnormality, Southeast Asian ovalocytosis (SAO)."1.56A case series of distal renal tubular acidosis, Southeast Asian ovalocytosis and metabolic bone disease. ( Dissanayake, D; Gunaratne, W; Jayaratne, K; Premawardhana, NP; Siribaddana, S, 2020)
"Distal renal tubular acidosis was associated with chronic renal failure of different severity and with tubulointerstitial diseases in the two-third of patients in whom histologic studies were also performed."1.29[Clinical spectrum of distal renal tubular acidosis and its study with bicarbonate loading]. ( Pató, E; Radó, J, 1994)
"Severe renal tubular acidosis associated with massive osteomalacia is described in a patient with Crohn's disease."1.27Severe osteomalacia associated with renal tubular acidosis in Crohn's disease. ( de Moura, MC; Lucas, MB; Victorino, RM, 1986)
"The results show that successful treatment of the osteomalacia of chronic acidosis is not necessarily accompanied by changes in the plasma levels of vitamin D metabolites and that even when marked glomerular dysfunction coexists with acidosis and osteomalacia, treatment with alkali may be more appropriate than the administration of vitamin D analogues."1.26Chronic acidosis with metabolic bone disease. Effect of alkali on bone morphology and vitamin D metabolism. ( Clemens, TL; Cunningham, J; Fraher, LJ; Papapoulos, SE; Revell, PA, 1982)
"Osteomalacia was shown by a radiological bone survey."1.25Fanconi's syndrome in an adult. A case history. ( Naidoo, PM, 1975)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199032 (78.05)18.7374
1990's6 (14.63)18.2507
2000's1 (2.44)29.6817
2010's1 (2.44)24.3611
2020's1 (2.44)2.80

Authors

AuthorsStudies
Gunaratne, W1
Dissanayake, D1
Jayaratne, K1
Premawardhana, NP1
Siribaddana, S1
Cano Megías, M1
Muñoz Delgado, EG1
HENNEMAN, PH1
DEMPSEY, EF1
CARROLL, EL1
HENNEMAN, DH1
FLETCHER, RF1
JONES, JH1
MORGAN, DB1
Wilkins, SA1
Salahudeen, AK1
Elliott, RW1
Ellis, HA1
Justado Ruiz-Capillas, JJ1
García Puig, J1
Molina, F1
García Delgado, E1
Arnalich, F1
Mateos Antón, F1
Vázquez, JJ1
Cunningham, J1
Fraher, LJ1
Clemens, TL1
Revell, PA1
Papapoulos, SE1
Siklos, P1
Davie, M1
Jung, RT1
Chalmers, TM1
Radó, J1
Pató, E1
Radó, JP1
Haris, A1
Cachat, F1
Froidevaux, V1
Guignard, JP1
Atik, A2
Ghazali, A2
Achard, JM2
Rida, Z1
Oprisiu, R2
Brazier, M1
Leflon, P1
Gueris, J1
Morinière, P2
Sari, Z1
Fournier, A2
Hottelart, C1
Yverneau, PH1
Hedri, H1
Said, S1
Sechet, A1
Rasolombololona, M1
Abighanem, O1
Sarraj, A1
El Esper, N1
Boudailliez, B1
Westeel, PF1
Pruna, A1
Lemann, J1
Adams, ND1
Wilz, DR1
Brenes, LG1
Genova, R1
Guerra, A1
Tamburini, P1
Angrisano, A1
Radice, R1
Münch, UH1
Lupi, G1
Kistler, HJ1
Latorzeff, S1
Pujol, M1
Arlet, J1
Naidoo, PM1
Ahmed, KY2
Varghese, Z2
Moorhead, JF2
Wills, MR2
Texter, EC1
Smart, DF1
Butler, RC1
Harrison, NA1
Bateman, JM1
Ledingham, JG1
Smith, R2
Bailey, RR1
Leopolder-Ochsendorf, A1
Holtermüller, KH1
Victorino, RM1
Lucas, MB1
de Moura, MC1
Richards, P2
Chamberlain, MJ1
Wrong, OM2
Baillod, RA1
Tatler, GL1
Knapp, MS1
Gough, KR1
Axelsson, U1
Floyd, M1
Ayyar, DR1
Barwick, DD1
Hudgson, P1
Weightman, D1
Ingham, JP1
Kleerekoper, M1
Stewart, JH1
Posen, S1
Cochran, M1
Bulusu, L1
Horsman, A1
Stasiak, L1
Nordin, BE1
Lee, DB1
Drinkard, JP1
Rosen, VJ1
Gonick, HC1
Lennon, EJ1
Donohoe, JF1
Freaney, R2
Muldowney, FP2
Hossain, M1
Dick, M1
McGeeney, D1
York, SE1
Yendt, ER1
Stanbury, SW1
Lumb, GA1

Reviews

5 reviews available for hydrogen carbonate and Osteomalacia

ArticleYear
Bone and metabolic complications of urinary diversions.
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2015, Volume: 62, Issue:2

    Topics: Acidosis; Alkalosis; Bicarbonates; Bone Diseases, Metabolic; Calcium; Chlorides; Colon; Gastric Muco

2015
[Renal tubular acidosis in children].
    Pediatrie, 1993, Volume: 48, Issue:4

    Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Bicarbonates; Child; Female; Growth Disorders; Human

1993
Renal osteodystrophy in dialysis patients: diagnosis and treatment.
    Artificial organs, 1998, Volume: 22, Issue:7

    Topics: Adult; Alkaline Phosphatase; Aluminum; Bicarbonates; Biopsy; Calcifediol; Calcium; Calcium Carbonate

1998
[Distal tubular acidosis].
    Minerva medica, 1979, Oct-13, Volume: 70, Issue:44

    Topics: Acidosis, Renal Tubular; Adult; Alkalies; Bicarbonates; Body Weight; Citric Acid Cycle; Erythrocytes

1979
Renal failure in adult onset hypophosphatemic osteomalacia with Fanconi syndrome: a family study and review of the literature.
    Clinical nephrology, 1991, Volume: 35, Issue:4

    Topics: Acidosis, Renal Tubular; Adolescent; Adult; Bicarbonates; Child; Child, Preschool; Diabetes Complica

1991

Other Studies

36 other studies available for hydrogen carbonate and Osteomalacia

ArticleYear
A case series of distal renal tubular acidosis, Southeast Asian ovalocytosis and metabolic bone disease.
    BMC nephrology, 2020, 08-05, Volume: 21, Issue:1

    Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Adult; Anion Exchange Protein 1, Erythrocyte; Bicarb

2020
Acquired vitamin D-resistant osteomalacia: a new variety characterized by hypercalcemia, low serum bicarbonate and hyperglycinuria.
    Metabolism: clinical and experimental, 1962, Volume: 11

    Topics: Amino Acid Metabolism, Inborn Errors; Bicarbonates; Calcium; Glycine; Humans; Hypercalcemia; Osteoma

1962
BONE DISEASE IN CHRONIC RENAL FAILURE.
    The Quarterly journal of medicine, 1963, Volume: 32

    Topics: Alkalies; Aluminum; Bicarbonates; Blood Chemical Analysis; Bone Diseases; Calcium; Ergocalciferols;

1963
Management of chronic hyperchloremic acidosis.
    Annals of surgery, 1967, Volume: 165, Issue:6

    Topics: Acidosis; Bicarbonates; Female; Humans; Kidney Diseases; Middle Aged; Osteomalacia; Radiation Injuri

1967
Osteomalacia due to ileal replacement of ureters: report of 2 cases.
    The Journal of urology, 1984, Volume: 131, Issue:2

    Topics: Acidosis; Adolescent; Adult; Bicarbonates; Female; Humans; Hydroxycholecalciferols; Ileum; Osteomala

1984
[Monoclonal IgG lambda paraprotein, Fanconi's syndrome of the adult, and osteomalacia (author's transl)].
    Medicina clinica, 1981, May-10, Volume: 76, Issue:10

    Topics: Aged; Bicarbonates; Fanconi Syndrome; Female; Humans; Immunoglobulin G; Immunoglobulin lambda-Chains

1981
Chronic acidosis with metabolic bone disease. Effect of alkali on bone morphology and vitamin D metabolism.
    The American journal of medicine, 1982, Volume: 73, Issue:2

    Topics: Acidosis; Adult; Bicarbonates; Bone and Bones; Chlorides; Chronic Disease; Female; Humans; Male; Ost

1982
Osteomalacia in ureterosigmoidostomy: healing by correction of the acidosis.
    British journal of urology, 1980, Volume: 52, Issue:1

    Topics: Bicarbonates; Colon, Sigmoid; Humans; Male; Middle Aged; Osteomalacia; Time Factors; Ureter; Urinary

1980
[Clinical spectrum of distal renal tubular acidosis and its study with bicarbonate loading].
    Orvosi hetilap, 1994, Dec-04, Volume: 135, Issue:49

    Topics: Acidosis, Renal Tubular; Adult; Aged; Bicarbonates; Diabetes Insipidus; Female; Humans; Hyperkalemia

1994
Metabolic bone disease (anticonvulsant osteomalacia) and renal tubular acidosis in tuberous sclerosis.
    Internal medicine (Tokyo, Japan), 1993, Volume: 32, Issue:7

    Topics: Acidosis, Renal Tubular; Adult; Back Pain; Bicarbonates; Bone and Bones; Calcitriol; Calcium; Calciu

1993
[Relative depletion in native vitamin D: a potential risk factor in Algerian hemodialysis patients with radiological evidence of hyperparathyroidism and osteomalacia independent of calcitriolemia].
    Nephrologie, 1997, Volume: 18, Issue:2

    Topics: Adult; Algeria; Aluminum; Bicarbonates; Calcifediol; Calcitriol; Calcium; Female; Humans; Hyperparat

1997
Acid and mineral balances and bone in familial proximal renal tubular acidosis.
    Kidney international, 2000, Volume: 58, Issue:3

    Topics: Absorptiometry, Photon; Acid-Base Equilibrium; Acidosis, Renal Tubular; Adult; Bicarbonates; Bone De

2000
[Osteomalacia and antiepileptic drugs: study on the pathogenesis].
    Schweizerische medizinische Wochenschrift, 1975, May-10, Volume: 105, Issue:19

    Topics: Adult; Anticonvulsants; Bicarbonates; Blood Proteins; Calcium; Cholecalciferol; Cholesterol; Creatin

1975
[Osteomalacia of complex etiology revealing a distal tubulopathy in an adult].
    Revue du rhumatisme et des maladies osteo-articulaires, 1975, Volume: 42, Issue:1

    Topics: Acidosis, Renal Tubular; Adult; Alkalies; Alkalosis; Bicarbonates; Calcium; Humans; Hydrogen-Ion Con

1975
Fanconi's syndrome in an adult. A case history.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1975, Jul-19, Volume: 49, Issue:31

    Topics: Adult; Bicarbonates; Fanconi Syndrome; Female; Glycosuria; Humans; Hydrogen-Ion Concentration; Hypok

1975
The response to 1,25-dihydroxycholecalciferol and to dihydrotachysterol in adult-onset hypophosphataemic osteomalacia.
    Clinica chimica acta; international journal of clinical chemistry, 1979, Sep-15, Volume: 97, Issue:1

    Topics: Amino Acids; Bicarbonates; Calcium; Chlorides; Dihydrotachysterol; Dihydroxycholecalciferols; Ergoca

1979
Antacids.
    American family physician, 1975, Volume: 11, Issue:4

    Topics: Alkalosis; Aluminum Hydroxide; Antacids; Bicarbonates; Calcium Carbonate; Constipation; Costs and Co

1975
Chronic acidosis with metabolic bone disease.
    The New Zealand medical journal, 1985, Jun-26, Volume: 98, Issue:781

    Topics: Acidosis; Adult; Bicarbonates; Chlorides; Female; Humans; Osteomalacia; Rectum; Sodium; Sodium Bicar

1985
[Side effects of antacids].
    Deutsche medizinische Wochenschrift (1946), 1985, Aug-02, Volume: 110, Issue:31-32

    Topics: Alkalosis; Aluminum Hydroxide; Antacids; Bicarbonates; Brain Diseases; Calcium; Constipation; Diarrh

1985
Severe osteomalacia associated with renal tubular acidosis in Crohn's disease.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:3

    Topics: Acidosis, Renal Tubular; Administration, Oral; Bicarbonates; Crohn Disease; Gait; Humans; Infusions,

1986
Treatment of osteomalacia of renal tubular acidosis by sodium bicarbonate alone.
    Lancet (London, England), 1972, Nov-11, Volume: 2, Issue:7785

    Topics: Acidosis, Renal Tubular; Adult; Bicarbonates; Ergocalciferols; Female; Humans; Kidney Diseases; Midd

1972
Dominant inheritance in a family with familial renal tubular acidosis.
    Lancet (London, England), 1972, Nov-11, Volume: 2, Issue:7785

    Topics: Acidosis, Renal Tubular; Adult; Bicarbonates; Child; Female; Growth Disorders; Humans; Kidney Concen

1972
Hypophosphataemic osteomalacia after cadaveric renal transplantation.
    Lancet (London, England), 1974, Apr-20, Volume: 1, Issue:7860

    Topics: Acidosis; Alkaline Phosphatase; Azathioprine; Bicarbonates; Cadaver; Calcium; Chlorides; Creatinine;

1974
An unusual neurological manifestation of hypocalcaemia.
    Lancet (London, England), 1967, Mar-04, Volume: 1, Issue:7488

    Topics: Adolescent; Adult; Anemia, Macrocytic; Bicarbonates; Calcium; Ergocalciferols; Female; Folic Acid De

1967
Plasma cell nephropathy with renal tubular acidosis.
    Acta medica Scandinavica, 1969, Volume: 186, Issue:6

    Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Adult; Alkaline Phosphatase; Autoimmune Diseases; Bi

1969
Myopathy in chronic renal failure.
    The Quarterly journal of medicine, 1974, Volume: 43, Issue:172

    Topics: Action Potentials; Adult; Alkaline Phosphatase; Bicarbonates; Calcium; Child; Creatinine; Electromyo

1974
Symptomatic skeletal disease in non-terminal renal failure.
    The Medical journal of Australia, 1974, Jun-01, Volume: 1, Issue:22

    Topics: Adult; Aged; Alkaline Phosphatase; Analgesics; Bicarbonates; Bone Diseases; Calcium; Chronic Kidney

1974
Hypocalcaemia and bone disease in renal failure.
    Nephron, 1973, Volume: 10, Issue:2

    Topics: Absorptiometry, Photon; Acidosis; Adolescent; Adult; Aged; Alkaline Phosphatase; Bicarbonates; Biops

1973
The adult Fanconi syndrome: observations on etiology, morphology, renal function and mineral metabolism in three patients.
    Medicine, 1972, Volume: 51, Issue:2

    Topics: Adult; Bicarbonates; Biological Transport; Calcium; Fanconi Syndrome; Glycosuria; Humans; Ilium; Kid

1972
Metabolic acidosis. A factor in the pathogenesis of azotemic osteodystrophy?
    Archives of internal medicine, 1969, Volume: 124, Issue:5

    Topics: Acidosis; Adult; Ammonium Chloride; Bicarbonates; Bone Diseases; Calcium; Humans; Hydrogen-Ion Conce

1969
Osteomalacia in ureterosigmoidostomy.
    Irish journal of medical science, 1969, Volume: 8, Issue:11

    Topics: Acidosis; Bicarbonates; Colon, Sigmoid; Humans; Male; Middle Aged; Osteomalacia; Phosphates; Postope

1969
The osteomalacia syndrome after colocystoplasty; a cure with sodium bicarbonate alone.
    British journal of urology, 1970, Volume: 42, Issue:2

    Topics: Alkaline Phosphatase; Bicarbonates; Blood Urea Nitrogen; Bone and Bones; Calcium; Chlorides; Colon;

1970
Total urinary hydroxyproline in osteomalacia and the effect upon it of treatment with vitamin D.
    Clinical science, 1968, Volume: 34, Issue:1

    Topics: Acidosis, Renal Tubular; Adult; Aged; Alkaline Phosphatase; Bicarbonates; Bone and Bones; Calcium; F

1968
Renal tubular acidosis and amino-aciduria in osteomalacia of dietary or intestinal origin.
    The Quarterly journal of medicine, 1968, Volume: 37, Issue:148

    Topics: Acidosis, Renal Tubular; Adolescent; Adult; Aged; Ammonium Chloride; Bicarbonates; Blood; Calcium; C

1968
Osteomalacia associated with renal bicarbonate loss.
    Canadian Medical Association journal, 1966, Jun-25, Volume: 94, Issue:26

    Topics: Acidosis; Adult; Bicarbonates; Blood; Female; Humans; Osteomalacia; Vitamin D; Vitamin D Deficiency

1966
Parathyroid function in chronic renal failure. A statistical survey of the plasma biochemistry in azotaemic renal osteodystrophy.
    The Quarterly journal of medicine, 1966, Volume: 35, Issue:137

    Topics: Bicarbonates; Blood Proteins; Blood Urea Nitrogen; Calcium; Chronic Kidney Disease-Mineral and Bone

1966