Page last updated: 2024-10-18

hydrogen carbonate and Neoplasms

hydrogen carbonate has been researched along with Neoplasms in 64 studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"There were no metastases in 9 cases."2.67[Dynamics of bioelectric activity of the brain and erythrocyte ultrastructure after intravenous infusion of sodium bicarbonate to oncologic patients]. ( Davydova, IG; Filippova, NA; Kassil', VL; Raĭkhlin, NT, 1992)
"The most aggressive and invasive cancers, which are often hypoxic, rely on exacerbated glycolysis to meet the increased demand for ATP and biosynthetic precursors and also rely on robust pH-regulating systems to combat the excessive generation of lactic and carbonic acids."2.49Disrupting proton dynamics and energy metabolism for cancer therapy. ( Chiche, J; Parks, SK; Pouysségur, J, 2013)
"Altering the pH around tumors might represent a way to hamper tumor development as suggested by a recent work demonstrating that bicarbonate, which increases the pH of tumors, prevented spontaneous metastatization."2.46Glucose metabolism in cancer cells. ( Annibaldi, A; Widmann, C, 2010)
"Tumorigenesis and metastasis are associated with metabolic reprogramming, including enhanced glycolysis and glutaminolysis."2.46Dynamic nuclear polarization in metabolic imaging of metastasis: common sense, hypersense and compressed sensing. ( Dafni, H; Ronen, SM, 2010)
"Zoledronic acid (ZA) is an antiresorptive agent typically used for fracture prevention in postmenopausal osteoporosis, malignancy-associated metastatic bone lesions, and as a treatment for hypercalcemia."1.72Zoledronic Acid-Associated Fanconi Syndrome in Patients With Cancer. ( Gupta, S; Mount, DB; Nigwekar, SU; Portales-Castillo, I; Rennke, HG; Yu, EW, 2022)
"After adjusting for respiratory failure, malignant cancer, anticoagulation, liver disease, white blood cell (WBC), red cell distribution width (RDW), glucose, bicarbonate, and temperature, BUN/Cr had week correlation with the increased risk of in-hospital mortality of cerebral infarction patients (RR = 1."1.72The Association of Blood Urea Nitrogen to Creatinine Ratio and the Prognosis of Critically Ill Patients with Cerebral Infarction: A Cohort Study. ( Chen, T; Gong, Q; Li, AP; Zhao, YX; Zhou, L; Zhou, WS; Zhou, ZW, 2022)
" Many synergists such as microbubbles and perfluorocarbon nanoparticles have recently been used to improve HIFU treatment efficiency, but none were determined to be effective and safe in vivo."1.46High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring. ( Cao, Y; Feng, G; Hao, L; Li, P; Ran, H; Wang, Q; Wang, Z; Xia, J; Xu, C; Zheng, Y, 2017)
"In 8 of 10 cancer cell lines, we found that hypoxia induced the expression of at least one bicarbonate transporter."1.43Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth. ( Bridges, E; Harris, AL; Hulikova, A; Jones, D; Ledaki, I; Li, JL; McIntyre, A; Russell, A; Seden, P; Singleton, D; Snell, C; Steers, G; Swietach, P; Wigfield, S, 2016)
"In solid tumors, time-dependence of blood flow can result in fluctuations of CO2 partial pressure (pCO2) that disturb cytoplasmic CO2-HCO3(-)-H(+) equilibrium."1.40Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure. ( Aveyard, N; Harris, AL; Hulikova, A; Swietach, P; Vaughan-Jones, RD, 2014)
"Understanding cancer cell metabolism and targeting associated pathways is a field of increasing interest."1.35Fingerprint of cell metabolism in the experimentally observed interstitial pH and pO2 in solid tumors. ( Kohandel, M; Milosevic, M; Molavian, HR; Sivaloganathan, S, 2009)
"It is suggested that acid conditions in tumors might allow the development of new and relatively specific types of therapy which are directed against mechanisms which regulate pHi under acid conditions."1.28Acid pH in tumors and its potential for therapeutic exploitation. ( Rotin, D; Tannock, IF, 1989)
" No significant relationship was observed between alpha value and total amount of transfusion, of urine or dosage of sodium bicarbonate."1.27[Effect of IV hydration with sodium bicarbonate on high-dose methotrexate disposition kinetics]. ( Goto, M; Konishi, H; Tsuda, N; Yamashina, H, 1984)

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-199023 (35.94)18.7374
1990's5 (7.81)18.2507
2000's7 (10.94)29.6817
2010's20 (31.25)24.3611
2020's9 (14.06)2.80

Authors

AuthorsStudies
Portales-Castillo, I1
Mount, DB1
Nigwekar, SU1
Yu, EW1
Rennke, HG1
Gupta, S1
Feng, Y1
Liu, Y1
Ma, X1
Xu, L1
Ding, D1
Chen, L1
Wang, Z2
Qin, R1
Sun, W1
Chen, H1
Li, Y2
Gao, R1
Zhao, B1
Zhang, Y1
Xiu, M1
Li, L1
Gao, Y1
Chen, T1
Li, AP1
Gong, Q1
Zhou, L1
Zhao, YX1
Zhou, ZW1
Zhou, WS1
Al-Kindi, SG1
Sarode, A1
Zullo, M1
Rajagopalan, S1
Rahman, M1
Hostetter, T1
Dobre, M1
Ramirez, C1
Hauser, AD1
Vucic, EA1
Bar-Sagi, D1
Lee, D1
Hong, JH1
Langella, E1
Buonanno, M1
De Simone, G2
Monti, SM2
Chafe, SC1
Vizeacoumar, FS1
Venkateswaran, G1
Nemirovsky, O1
Awrey, S1
Brown, WS1
McDonald, PC1
Carta, F1
Metcalfe, A1
Karasinska, JM1
Huang, L1
Muthuswamy, SK1
Schaeffer, DF1
Renouf, DJ1
Supuran, CT4
Vizeacoumar, FJ1
Dedhar, S1
Feng, G1
Hao, L1
Xu, C1
Ran, H1
Zheng, Y1
Li, P1
Cao, Y1
Wang, Q1
Xia, J1
Zhang, N1
Li, J1
Hou, R1
Zhang, J1
Wang, P1
Liu, X1
Zhang, Z1
Kondo, A1
Osawa, T1
Hendrie, JD1
Chauhan, A1
Nelson, NR1
Anthony, LB1
Parks, SK1
Chiche, J2
Pouysségur, J2
Hulikova, A5
Aveyard, N1
Harris, AL4
Vaughan-Jones, RD4
Swietach, P5
Alka, K1
Casey, JR1
Nelson, B1
McIntyre, A1
Ledaki, I1
Snell, C1
Singleton, D1
Steers, G1
Seden, P1
Jones, D1
Bridges, E1
Wigfield, S1
Li, JL1
Russell, A1
Galant, NJ1
Wang, H1
Lee, DR1
Mucsi, Z1
Setiadi, DH1
Viskolcz, B1
Csizmadia, IG1
Alterio, V1
Hilvo, M1
Di Fiore, A1
Pan, P1
Parkkila, S1
Scaloni, A1
Pastorek, J2
Pastorekova, S2
Pedone, C1
Scozzafava, A1
Ilc, K1
Brahimi-Horn, MC1
Molavian, HR1
Kohandel, M1
Milosevic, M1
Sivaloganathan, S1
Annibaldi, A1
Widmann, C1
Martin, NK2
Gaffney, EA2
Gatenby, RA2
Gillies, RJ2
Robey, IF2
Maini, PK2
Dafni, H1
Ronen, SM1
Neri, D1
Ditte, P1
Dequiedt, F1
Svastova, E1
Ohradanova-Repic, A1
Zatovicova, M1
Csaderova, L1
Kopacek, J1
Jiang, X1
Zhang, JT1
Chan, HC1
CLINE, JK1
HOWLE, J1
REID, J1
JOHNSON, L1
HEYN, R1
NEWTON, W1
CARTER, R1
BARON, F1
MITARD, JJ1
VALLA, A1
MOINADE, S1
KIMURA, Y1
NIWA, T1
KOMEIJI, T1
Lina, BA2
Kuijpers, MH1
Chauveau, P1
Nguyen, H1
Combe, C1
Chêne, G1
Azar, R1
Cano, N1
Canaud, B1
Fouque, D1
Laville, M1
Leverve, X1
Roth, H1
Aparicio, M1
Wike-Hooley, JL1
Haveman, J1
Reinhold, HS1
Tsuda, N1
Goto, M1
Konishi, H1
Yamashina, H1
Guntupalli, KK1
Sladen, A1
Selker, RG1
Weinstock, E1
Wilks, DH1
Passmore, J1
Guntupalli, JS1
Lieberman, D1
Reshef, A1
Alroy, G1
Freaney, R1
Ryan, E1
Muldowney, FP1
Narins, RG1
Rudnick, MR1
Bastl, CP1
de Groot, AP1
Hagenaars, AJ1
Hollanders, VM1
Andringa, M1
Feron, VJ1
Mercadante, S1
Agaliotis, DP1
Ballester, OF1
Mattox, T1
Hiemenz, JW1
Fields, KK1
Zorsky, PE1
Goldstein, SC1
Perkins, JB1
Rosen, RM1
Elfenbein, GJ1
Nilsson, E1
Fontes, E1
Dreizen, S1
Brown, LR1
Handler, S1
Levy, BM1
Fuchs, D1
Hermann, J1
Zintl, F1
Plenert, W1
Nirenberg, A1
Mosende, C1
Mehta, BM1
Gisolfi, AL1
Rosen, G1
Davydova, IG1
Kassil', VL1
Raĭkhlin, NT1
Filippova, NA1
Conley, BA1
Egorin, MJ1
Sinibaldi, V1
Sewack, G1
Kloc, C1
Roberts, L1
Zuhowski, EG1
Forrest, A1
Van Echo, DA1
Tannock, IF1
Rotin, D1
Poli, S1
Vincent, A1
Perret, C1
Lomanto, C1
Howland, WS2
Light, RW1
MacGregor, MI1
Ball, WC1
Luchsinger, PC1
Gerhard, W1
Wills, MR1
Boyan, CP1
Rauen, HM1
Norpoth, K1
Kramer, KP1

Reviews

14 reviews available for hydrogen carbonate and Neoplasms

ArticleYear
An update regarding the role of WNK kinases in cancer.
    Cell death & disease, 2022, 09-19, Volume: 13, Issue:9

    Topics: Alanine; Animals; Bicarbonates; Mammals; Neoplasms; Neovascularization, Pathologic; Proline; Serine;

2022
The Fundamental Role of Bicarbonate Transporters and Associated Carbonic Anhydrase Enzymes in Maintaining Ion and pH Homeostasis in Non-Secretory Organs.
    International journal of molecular sciences, 2020, Jan-04, Volume: 21, Issue:1

    Topics: Bicarbonates; Carbonic Anhydrases; Gastrointestinal Tract; Humans; Hydrogen-Ion Concentration; Immun

2020
Intrinsically disordered features of carbonic anhydrase IX proteoglycan-like domain.
    Cellular and molecular life sciences : CMLS, 2021, Volume: 78, Issue:5

    Topics: Bicarbonates; Biocatalysis; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Ca

2021
Disrupting proton dynamics and energy metabolism for cancer therapy.
    Nature reviews. Cancer, 2013, Volume: 13, Issue:9

    Topics: Autophagy; Bicarbonates; Carbonic Acid; Carbonic Anhydrases; Cation Transport Proteins; Energy Metab

2013
Bicarbonate transport in health and disease.
    IUBMB life, 2014, Volume: 66, Issue:9

    Topics: Animals; Bicarbonates; Carbon Dioxide; Chloride-Bicarbonate Antiporters; Humans; Mice; Models, Molec

2014
Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration.
    Advances in enzyme regulation, 2010, Volume: 50, Issue:1

    Topics: Animals; Bicarbonates; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Line, Tumor; Cell Me

2010
Glucose metabolism in cancer cells.
    Current opinion in clinical nutrition and metabolic care, 2010, Volume: 13, Issue:4

    Topics: Aerobiosis; Animals; Apoptosis; Bicarbonates; Cell Proliferation; Glucose; Glycolysis; Humans; Hydro

2010
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation.
    Oncogene, 2010, Dec-16, Volume: 29, Issue:50

    Topics: Animals; Antigens, Neoplasm; Bicarbonates; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia;

2010
Dynamic nuclear polarization in metabolic imaging of metastasis: common sense, hypersense and compressed sensing.
    Cancer biomarkers : section A of Disease markers, 2010, Volume: 7, Issue:4

    Topics: Bicarbonates; Diagnostic Imaging; Glutamine; Humans; Magnetic Resonance Spectroscopy; Neoplasm Metas

2010
Interfering with pH regulation in tumours as a therapeutic strategy.
    Nature reviews. Drug discovery, 2011, Sep-16, Volume: 10, Issue:10

    Topics: Acidosis; Animals; Antineoplastic Agents; Bicarbonates; Carbonic Anhydrase Inhibitors; Humans; Hydro

2011
Ion channels/transporters as epigenetic regulators? -a microRNA perspective.
    Science China. Life sciences, 2012, Volume: 55, Issue:9

    Topics: Animals; Bicarbonates; Cystic Fibrosis Transmembrane Conductance Regulator; Embryo, Mammalian; Epige

2012
Regulation of tumor pH and the role of carbonic anhydrase 9.
    Cancer metastasis reviews, 2007, Volume: 26, Issue:2

    Topics: Antigens, Neoplasm; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Humans

2007
The relevance of tumour pH to the treatment of malignant disease.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1984, Volume: 2, Issue:4

    Topics: Animals; Antineoplastic Agents; Bicarbonates; Cell Line; Cell Survival; Combined Modality Therapy; C

1984
[Lactic acidosis].
    Annales francaises d'anesthesie et de reanimation, 1985, Volume: 4, Issue:1

    Topics: Acidosis; Bicarbonates; Biguanides; Diabetes Mellitus; Epilepsy; Ethanol; Fructose; Heart Failure; H

1985

Trials

2 trials available for hydrogen carbonate and Neoplasms

ArticleYear
High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity.
    Cancer treatment reports, 1977, Volume: 61, Issue:5

    Topics: Bicarbonates; Drug Interactions; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neopla

1977
[Dynamics of bioelectric activity of the brain and erythrocyte ultrastructure after intravenous infusion of sodium bicarbonate to oncologic patients].
    Biulleten' eksperimental'noi biologii i meditsiny, 1992, Volume: 113, Issue:4

    Topics: Acidosis; Adolescent; Adult; Bicarbonates; Brain; Electroencephalography; Erythrocytes; Female; Huma

1992

Other Studies

48 other studies available for hydrogen carbonate and Neoplasms

ArticleYear
Zoledronic Acid-Associated Fanconi Syndrome in Patients With Cancer.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2022, Volume: 80, Issue:4

    Topics: Acute Kidney Injury; Amino Acids; Bicarbonates; Bone Density Conservation Agents; Fanconi Syndrome;

2022
Intracellular marriage of bicarbonate and Mn ions as "immune ion reactors" to regulate redox homeostasis and enhanced antitumor immune responses.
    Journal of nanobiotechnology, 2022, Apr-19, Volume: 20, Issue:1

    Topics: Bicarbonates; Cell Line, Tumor; Homeostasis; Humans; Immunity; Neoplasms; Oxidation-Reduction

2022
Low Serum Bicarbonate Levels Increase the Risk of All-Cause, Cardiovascular Disease, and Cancer Mortality in Type 2 Diabetes.
    The Journal of clinical endocrinology and metabolism, 2022, 11-23, Volume: 107, Issue:11

    Topics: Adult; Bicarbonates; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Neoplasms; Nutritio

2022
The Association of Blood Urea Nitrogen to Creatinine Ratio and the Prognosis of Critically Ill Patients with Cerebral Infarction: A Cohort Study.
    Mediators of inflammation, 2022, Volume: 2022

    Topics: Anticoagulants; Bicarbonates; Blood Urea Nitrogen; Cerebral Infarction; Cohort Studies; Creatinine;

2022
Serum Bicarbonate Concentration and Cause-Specific Mortality: The National Health and Nutrition Examination Survey 1999-2010.
    Mayo Clinic proceedings, 2020, Volume: 95, Issue:1

    Topics: Aged; Bicarbonates; Cardiovascular Diseases; Cause of Death; Cohort Studies; Correlation of Data; Fe

2020
Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis.
    Nature, 2019, Volume: 576, Issue:7787

    Topics: Animals; Bicarbonates; Carcinogenesis; Cell Line, Tumor; Cell Membrane; Cholesterol; Cyclic AMP-Depe

2019
Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.
    Science advances, 2021, Volume: 7, Issue:35

    Topics: Bicarbonates; Carbon-Sulfur Lyases; Carbonic Anhydrase IX; Cell Hypoxia; Cell Line, Tumor; Humans; H

2021
High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Animals; Bicarbonates; Cattle; Cell Line, Tumor; High-Intensity Focused Ultrasound Ablation; Liposom

2017
Bubble-generating nano-lipid carriers for ultrasound/CT imaging-guided efficient tumor therapy.
    International journal of pharmaceutics, 2017, Dec-20, Volume: 534, Issue:1-2

    Topics: Bicarbonates; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation;

2017
Establishment of an Extracellular Acidic pH Culture System.
    Journal of visualized experiments : JoVE, 2017, 11-19, Issue:129

    Topics: Bicarbonates; Cell Culture Techniques; Culture Media; Humans; Hydrogen-Ion Concentration; Lactic Aci

2017
Can an amino acid-based oral rehydration solution be effective in managing immune therapy-induced diarrhea?
    Medical hypotheses, 2019, Volume: 127

    Topics: Administration, Oral; Amino Acids; Antineoplastic Agents; Bicarbonates; Clinical Trials as Topic; Co

2019
Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure.
    The Journal of biological chemistry, 2014, Sep-12, Volume: 289, Issue:37

    Topics: Bicarbonates; Carbon Dioxide; Carbonic Anhydrases; Cytoplasm; HCT116 Cells; Humans; Hydrogen-Ion Con

2014
A beam of hope for heavy ion radiotherapy: Promising clinical results and better designs are adding new momentum to the push for more proton and carbon ion radiotherapy centers.
    Cancer cytopathology, 2015, Volume: 123, Issue:8

    Topics: Bicarbonates; Cancer Care Facilities; Forecasting; Heavy Ion Radiotherapy; Humans; Neoplasms; Proton

2015
Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.
    Cancer research, 2016, 07-01, Volume: 76, Issue:13

    Topics: Animals; Antigens, Neoplasm; Apoptosis; Bicarbonates; Blotting, Western; Carbonic Anhydrase IX; Cell

2016
Thermodynamic role of glutathione oxidation by peroxide and peroxybicarbonate in the prevention of Alzheimer's disease and cancer.
    The journal of physical chemistry. A, 2009, Aug-13, Volume: 113, Issue:32

    Topics: Alzheimer Disease; Bicarbonates; Disulfides; Electrons; Gases; Glutathione; Glutathione Disulfide; I

2009
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Sep-22, Volume: 106, Issue:38

    Topics: Amino Acid Sequence; Antigens, Neoplasm; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase IX; Carbon

2009
Fingerprint of cell metabolism in the experimentally observed interstitial pH and pO2 in solid tumors.
    Cancer research, 2009, Dec-01, Volume: 69, Issue:23

    Topics: Bicarbonates; Carbon Dioxide; Computer Simulation; Glycolysis; Hydrogen-Ion Concentration; Lactic Ac

2009
A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system.
    Mathematical biosciences, 2011, Volume: 230, Issue:1

    Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Respiratory; Algorithms; Alkalosis; Alkalosis, Respirator

2011
Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths.
    The Journal of biological chemistry, 2011, Apr-22, Volume: 286, Issue:16

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Bicarbonates; Biological Transport; Buffers; Carbo

2011
Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.
    Cancer research, 2011, Dec-15, Volume: 71, Issue:24

    Topics: Antigens, Neoplasm; Bicarbonates; Carbonic Anhydrase IX; Carbonic Anhydrases; Catalytic Domain; Cell

2011
Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study.
    British journal of cancer, 2012, Mar-27, Volume: 106, Issue:7

    Topics: Alkalosis; Animals; Bicarbonates; Buffers; Humans; Hydrogen-Ion Concentration; Mice; Models, Biologi

2012
Effects of pH and bicarbonate content of serum in reducing methylene blue.
    Public health monograph, 1953, Volume: 12

    Topics: Bicarbonates; Blood; Humans; Methylene Blue; Neoplasms

1953
ELDERFIELD PYRIMIDINE MUSTARD (NSC-23436) IN ACUTE LEUKEMIA IN CHILDREN--A PHASE I STUDY.
    Cancer chemotherapy reports, 1963, Volume: 33

    Topics: Animals; Bicarbonates; Dogs; Hodgkin Disease; Leukemia; Leukemia L1210; Leukopenia; Mice; Mustard Pl

1963
[ANTALGIC EFFECT OF TH-2152 IN CANCER PATIENTS].
    Gazette medicale de France, 1964, Jun-10, Volume: 71

    Topics: Analgesia; Aspirin; Bicarbonates; Biomedical Research; Humans; Neoplasms; Pain Management; Palliativ

1964
[AN ADVANCE IN ANTALGIC THERAPEUTICS: SODIUM ACETYLSALICYLATE MONOSODIUM CARBONATE OR TH-2152].
    Gazette medicale de France, 1964, Jun-10, Volume: 71

    Topics: Analgesia; Aspirin; Bicarbonates; Biomedical Research; Humans; Neoplasms; Pain Management; Palliativ

1964
[EXPERIMENTATION AND ACTION OF TH-2152 IN THE CLINICAL MEDICINE DEPARTMENT].
    Gazette medicale de France, 1964, Jun-10, Volume: 71

    Topics: Arteritis; Aspirin; Bicarbonates; Biomedical Research; Clinical Medicine; Humans; Influenza, Human;

1964
Observations on the crabtree effect in Ehrlich ascites tumor cells, significance of bicarbonate.
    Gan, 1961, Volume: 52

    Topics: Animals; Bicarbonates; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; Glucose; Neoplasms

1961
Toxicity and carcinogenicity of acidogenic or alkalogenic diets in rats; effects of feeding NH(4)Cl, KHCO(3) or KCl.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2004, Volume: 42, Issue:1

    Topics: Acid-Base Equilibrium; Ammonium Chloride; Animals; Bicarbonates; Blood Gas Analysis; Bone and Bones;

2004
Dialyzer membrane permeability and survival in hemodialysis patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:3

    Topics: Aged; Bicarbonates; Body Composition; Body Mass Index; Cardiovascular Diseases; Cause of Death; Chol

2005
[Effect of IV hydration with sodium bicarbonate on high-dose methotrexate disposition kinetics].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Bicarbonates; Bone Neoplasms; Child; Female; Humans; Hydrogen-Ion Concentration;

1984
Effects of induced total-body hyperthermia on phosphorus metabolism in humans.
    The American journal of medicine, 1984, Volume: 77, Issue:2

    Topics: Bicarbonates; Blood Pressure; Cardiac Output; Electrolytes; Evaluation Studies as Topic; Glomerular

1984
[Reduced pH, glucose and bicarbonate in malignant pleural effusions].
    Harefuah, 1984, Dec-16, Volume: 107, Issue:12

    Topics: Bicarbonates; Blood Glucose; Humans; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Neoplasms;

1984
Differentiation of hypercalcaemia due to malignancy from primary hyperparathyroidism: the value of parathyroid hormone and plasma bicarbonate measurements.
    Irish journal of medical science, 1981, Volume: 150, Issue:1

    Topics: Bicarbonates; Calcium; Diagnosis, Differential; Humans; Hypercalcemia; Hyperparathyroidism; Neoplasm

1981
The kidney in health and disease: XVIII: lactic acidosis and the elevated anion gap (II).
    Hospital practice, 1980, Volume: 15, Issue:6

    Topics: Acidosis; Bicarbonates; Blood Chemical Analysis; Diabetes Mellitus; Hemodynamics; Humans; Hydrogen-I

1980
Effects of a dietary load of acid or base on changes induced by lactose in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:1

    Topics: Acid-Base Equilibrium; Alkaline Phosphatase; Ammonium Chloride; Animal Feed; Animals; Bicarbonates;

1995
Alkalinization is troublesome in advanced cancer patients with dyspnea.
    Journal of pain and symptom management, 1997, Volume: 13, Issue:6

    Topics: Acid-Base Equilibrium; Alkalosis; Bicarbonates; Dyspnea; Humans; Hypercapnia; Neoplasms; Respiratory

1997
Nephrotoxicity of high-dose ifosfamide/carboplatin/etoposide in adults undergoing autologous stem cell transplantation.
    The American journal of the medical sciences, 1997, Volume: 314, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Carboplatin; Creati

1997
Mathematical modelling of physicochemical reactions and transport processes occurring around a platinum cathode during the electrochemical treatment of tumours.
    Bioelectrochemistry (Amsterdam, Netherlands), 2001, Volume: 53, Issue:2

    Topics: Animals; Bicarbonates; Buffers; Electrochemistry; Models, Theoretical; Neoplasms; Platinum; Rats; So

2001
Radiation-induced xerostomia in cancer patients. Effect on salivary and serum electrolytes.
    Cancer, 1976, Volume: 38, Issue:1

    Topics: Adolescent; Adult; Aged; Bicarbonates; Calcium; Chlorides; Electrolytes; Female; Humans; Hydrogen-Io

1976
[Basic therapy in children with leukemia and a malignant tumors. II].
    Kinderarztliche Praxis, 1978, Volume: 46, Issue:3

    Topics: Allopurinol; Anaphylaxis; Anemia; Antibiotics, Antineoplastic; Bicarbonates; Blood Transfusion; Chil

1978
Approaches to optimal dosing of hexamethylene bisacetamide.
    Cancer chemotherapy and pharmacology, 1992, Volume: 31, Issue:1

    Topics: Acetamides; Acidosis; Adult; Aged; Bicarbonates; Clinical Trials, Phase I as Topic; Dose-Response Re

1992
Acid pH in tumors and its potential for therapeutic exploitation.
    Cancer research, 1989, Aug-15, Volume: 49, Issue:16

    Topics: Animals; Antineoplastic Agents; Bicarbonates; Carrier Proteins; Cell Division; Cell Survival; DNA, N

1989
A re-evaluation of massive blood replacement.
    Clinical anesthesia, 1972, Volume: 9, Issue:1

    Topics: Acid-Base Equilibrium; Alkalosis; Anesthesia, General; Bicarbonates; Blood Coagulation; Blood Preser

1972
Diagnostic significance of pleural fluid pH and PCO2.
    Chest, 1973, Volume: 64, Issue:5

    Topics: Bicarbonates; Carbon Dioxide; Diagnosis, Differential; Heart Failure; Humans; Hydrogen-Ion Concentra

1973
[Growth of tumor-adapted influenza A 0 virus in suspensions of Ehrlich ascites cells in vitro].
    Pathologia et microbiologia, 1971, Volume: 37, Issue:2

    Topics: Animals; Bicarbonates; Calcium; Carcinoma, Ehrlich Tumor; Cells, Cultured; Culture Media; Glucose; G

1971
Value of plasma chloride concentration and acid-base status in the differential diagnosis of hyperparathyroidism from other causes of hypercalcaemia.
    Journal of clinical pathology, 1971, Volume: 24, Issue:3

    Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Bicarbonates; Calcium; Carbon Dioxide; Chlorides; Humans

1971
Immediate and delayed mortality associated with massive blood transfusions.
    The Surgical clinics of North America, 1969, Volume: 49, Issue:2

    Topics: Acid-Base Equilibrium; Adult; Bicarbonates; Blood Preservation; Blood Transfusion; Buffers; Hemorrha

1969
[Fate of free bis(beta-chloroethyl)-amine in blood serum].
    Arzneimittel-Forschung, 1965, Volume: 15, Issue:9

    Topics: Animals; Antineoplastic Agents; Azirines; Bicarbonates; Blood; Chlorides; Ethylamines; Humans; In Vi

1965