hydrogen carbonate has been researched along with Lesch-Nyhan Syndrome in 3 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gausset, P | 1 |
| Vamos, E | 1 |
| Delespesse, G | 1 |
| Kulakowski, S | 1 |
| Duchateau, J | 1 |
| de Bruyn, C | 1 |
| Shambaugh, GE | 1 |
| Nuki, G | 1 |
| Astrin, K | 1 |
| Brenton, D | 1 |
| Cruikshank, M | 1 |
| Lever, J | 1 |
| Seegmiller, JE | 1 |
1 review available for hydrogen carbonate and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Pyrimidine biosynthesis.
Topics: Animals; Aspartate Carbamoyltransferase; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Carba | 1979 |
2 other studies available for hydrogen carbonate and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Differential responses to mitogen stimulation in lymphocytes from normal individuals and Lesch-Nyhan patients: influence of the bicarbonate buffer system.
Topics: Adolescent; Adult; B-Lymphocytes; Bicarbonates; Child; Humans; Lesch-Nyhan Syndrome; Lymphocyte Acti | 1980 |
Purine and pyrimidine nucleotides in some mutant human lymphoblasts.
Topics: Adenine Nucleotides; Bicarbonates; Guanine Nucleotides; Humans; Hypoxanthine Phosphoribosyltransfera | 1977 |