hydrogen carbonate has been researched along with Injury, Myocardial Reperfusion in 92 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In study 1 (constant flow perfusion) 8 groups (n = 6 hearts per group) were studied: (1) 40 minutes of global ischemia; (2) 2 minutes of St Thomas' Hospital infusion and 40 minutes of ischemia; (3) multidose (every 10 minutes) infusions of St Thomas' Hospital solution during 40 minutes of ischemia; (4) 2 minutes of esmolol infusion and 40 minutes of ischemia; (5) multidose (every 10 minutes) esmolol infusions during 40 minutes of ischemia; (6) continuous infusion of esmolol for 40 minutes during coronary perfusion; (7) intermittent (4 x 10 minutes) ischemia with ventricular fibrillation; and (8) intermittent (4 x 10 minutes) ischemia preceded by intermittent esmolol administration." | 3.71 | Myocardial protection: the efficacy of an ultra-short-acting beta-blocker, esmolol, as a cardioplegic agent. ( Bessho, R; Chambers, DJ, 2001) |
| "The effects of 5-(N,N-dimethyl)amiloride, a potent and specific Na(+)-H+ exchange inhibitor, were investigated in isolated perfused rabbit hearts subjected to ischemia and reperfusion." | 3.69 | Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy. ( Abe, T; Akita, T; Hotta, Y; Kodama, I; Koike, A; Murase, M; Takeya, K; Toyama, J, 1996) |
| "Pinacidil-treated hearts had significantly better recovery of left ventricular developed pressure (47 +/- 3." | 1.32 | K(ATP) channel opener protects neonatal rabbit heart better than St. Thomas' solution. ( Feng, J; Li, H; Rosenkranz, ER, 2003) |
| "Treatment with diltiazem improved the recovery of left ventricular developed pressure to 96." | 1.29 | Protective effects of diltiazem and ryanodine against ischemia-reperfusion injury in neonatal rabbit hearts. ( Abe, T; Akita, T; Kato, S; Kodama, I; Toyama, J, 1993) |
| "Pretreatment with coenzyme Q10 given intraperitoneally improved aortic flow, cardiac output, stroke volume, coronary flow, and heart rate." | 1.29 | Improvement of cardiac function impaired by repeated ischemic arrests in isolated rat hearts. ( Ali, K; Fukaya, Y; Furukawa, Y; Morimoto, M, 1993) |
| " Post-ischemic recovery of AoF (%AoF) showed the bell-shaped dose-response curve, and the optimal dose was 3 microM (Exp." | 1.28 | [The effects of protease inhibitor upon the ischemia-reperfusion injury]. ( Kawashima, Y; Kinoshita, H; Nakajima, N; Ohashi, T; Shibata, T; Shimada, Y; Yamamoto, F, 1992) |
| "When acadesine was given as an in vivo pretreatment (100 mg/kg i." | 1.28 | Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat. ( Bullough, D; Galiñanes, M; Hearse, DJ; Mullane, KM, 1992) |
| " In dose-response studies (with 0, 3,000, 6,000, 12,000, 30,000, or 60,000 units/kg; n = 8 per group), maximum recovery of LVDP was obtained with the administration of 12,000 units/kg of PEG-SOD." | 1.28 | PEG-SOD and myocardial protection. Studies in the blood- and crystalloid-perfused rabbit and rat hearts. ( Ezrin, A; Galiñanes, M; Hearse, DJ; Qiu, Y, 1992) |
| " Furthermore, a dose-response curve showed that a glucose concentration of 20 mmol/L gave no better recovery than 0 mmol/L, and glucose in St." | 1.28 | St. Thomas' Hospital cardioplegic solution. Beneficial effect of glucose and multidose reinfusions of cardioplegic solution. ( Du Toit, EF; Dunne, T; King, LM; Opie, LH; Owen, P; Reichart, B; von Oppell, UO, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (6.52) | 18.7374 |
| 1990's | 63 (68.48) | 18.2507 |
| 2000's | 17 (18.48) | 29.6817 |
| 2010's | 5 (5.43) | 24.3611 |
| 2020's | 1 (1.09) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, M | 1 |
| Jia, M | 1 |
| Wang, Q | 1 |
| Guo, Y | 1 |
| Li, C | 1 |
| Ren, B | 1 |
| Qian, F | 1 |
| Wu, J | 1 |
| Yoshihara, HA | 1 |
| Bastiaansen, JA | 1 |
| Berthonneche, C | 1 |
| Comment, A | 1 |
| Schwitter, J | 1 |
| Maruyama, Y | 2 |
| Chambers, DJ | 11 |
| Bockeria, LA | 1 |
| Movsesyan, RR | 1 |
| Ryabtsev, DV | 1 |
| Grigoryants, TR | 1 |
| Aarsaether, E | 1 |
| Stenberg, TA | 1 |
| Jakobsen, Ø | 1 |
| Busund, R | 1 |
| Xue, HM | 1 |
| He, GW | 2 |
| Huang, JH | 1 |
| Yang, Q | 1 |
| Vinten-Johansen, J | 1 |
| Lima, ML | 1 |
| Fiorelli, AI | 1 |
| Vassallo, DV | 1 |
| Batista, PR | 1 |
| Simoes, FV | 1 |
| Fiorim, J | 1 |
| Stefanon, I | 1 |
| Pinheiro, BB | 1 |
| Stolf, NA | 1 |
| Gomes, OM | 1 |
| Fuchs, F | 1 |
| Messmer, K | 1 |
| Kuppe, H | 1 |
| Habazettl, H | 2 |
| Bessho, R | 2 |
| Köksal, C | 1 |
| Süzer, O | 3 |
| Bozkurt, AK | 1 |
| Köseoğlu, S | 3 |
| Bull, DA | 1 |
| Maurer, J | 1 |
| Feng, J | 1 |
| Li, H | 1 |
| Rosenkranz, ER | 1 |
| Dobson, GP | 1 |
| Jones, MW | 1 |
| Dong, YY | 1 |
| Wu, M | 1 |
| Yim, AP | 1 |
| Saini, HK | 1 |
| Elimban, V | 1 |
| Ozcelikay, AT | 1 |
| Dhalla, NS | 1 |
| Pisarenko, OI | 1 |
| Studneva, IM | 1 |
| Lakomkin, VL | 1 |
| Timoshin, AA | 1 |
| Kapelko, VI | 1 |
| Kato, H | 1 |
| Galiñanes, M | 8 |
| Elliott, MJ | 1 |
| de Leval, MR | 1 |
| Hearse, DJ | 16 |
| Yuan, S | 1 |
| You, L | 1 |
| Zhu, L | 1 |
| Li, G | 1 |
| Liu, M | 1 |
| Dong, C | 2 |
| Tian, X | 1 |
| Liu, H | 1 |
| Karck, M | 2 |
| Ziemer, G | 1 |
| Zoeller, M | 1 |
| Schulte, S | 2 |
| Juergens, KD | 1 |
| Weisser, H | 1 |
| Haverich, A | 2 |
| Kolocassides, KG | 1 |
| Baker, EJ | 1 |
| Boerboom, LE | 3 |
| Olinger, GN | 3 |
| Baker, JE | 4 |
| Bolling, SF | 5 |
| Olszanski, DA | 2 |
| Childs, KF | 2 |
| Gallagher, KP | 4 |
| Ning, XH | 1 |
| Yuan, SM | 1 |
| Zhu, LB | 1 |
| Li, GS | 1 |
| Liu, MH | 1 |
| Yu, YF | 1 |
| Wang, DQ | 1 |
| Li, JC | 1 |
| Luo, J | 1 |
| Menasché, P | 1 |
| Termignon, JL | 1 |
| Pradier, F | 1 |
| Grousset, C | 1 |
| Mouas, C | 1 |
| Alberici, G | 1 |
| Weiss, M | 1 |
| Piwnica, A | 1 |
| Bloch, G | 1 |
| Görge, G | 1 |
| Erbel, R | 1 |
| Dobbertin, A | 1 |
| Hänggi, M | 1 |
| Hake, U | 1 |
| Meyer, J | 1 |
| Chong, YS | 1 |
| Cottier, DS | 1 |
| Gavin, JB | 2 |
| Aoki, M | 1 |
| Nomura, F | 1 |
| Mayer, JE | 1 |
| Konorev, EA | 1 |
| Struck, AT | 1 |
| Ramanujam, S | 1 |
| Thomas, JP | 1 |
| Radi, R | 1 |
| Kalyanaraman, B | 1 |
| Akita, T | 2 |
| Abe, T | 3 |
| Kato, S | 1 |
| Kodama, I | 2 |
| Toyama, J | 2 |
| Amrani, M | 4 |
| Allen, NJ | 2 |
| O'Shea, J | 1 |
| Corbett, J | 1 |
| Dunn, MJ | 1 |
| Tadjkarimi, S | 1 |
| Theodoropoulos, S | 1 |
| Pepper, J | 1 |
| Yacoub, MH | 3 |
| Ibuki, C | 1 |
| Avkiran, M | 2 |
| Ali, K | 1 |
| Morimoto, M | 1 |
| Fukaya, Y | 1 |
| Furukawa, Y | 1 |
| Powell, SR | 1 |
| Aiuto, L | 1 |
| Hall, D | 1 |
| Tortolani, AJ | 1 |
| Lawton, JS | 1 |
| Sepic, JD | 1 |
| Allen, CT | 1 |
| Hsia, PW | 1 |
| Damiano, RJ | 1 |
| Choong, YS | 1 |
| Shimada, Y | 3 |
| Schnabel, PA | 3 |
| Kilkowski, A | 1 |
| Koike, A | 1 |
| Hotta, Y | 1 |
| Takeya, K | 1 |
| Murase, M | 1 |
| Bical, OM | 1 |
| Gerhardt, MF | 1 |
| Paumier, D | 1 |
| Gaillard, D | 1 |
| Landais, P | 1 |
| Fromes, Y | 1 |
| Foiret, JC | 1 |
| Trivin, F | 1 |
| Vanetti, A | 1 |
| Irtun, O | 1 |
| Sørlie, D | 1 |
| Suleiman, MS | 2 |
| Moffatt, AC | 1 |
| Dihmis, WC | 2 |
| Caputo, M | 2 |
| Hutter, JA | 1 |
| Angelini, GD | 2 |
| Bryan, AJ | 2 |
| Katayama, O | 2 |
| Ledingham, S | 2 |
| Jayakumar, J | 2 |
| Smolenski, RT | 1 |
| Severs, N | 2 |
| Rothery, S | 2 |
| Goodwin, AT | 1 |
| Gray, CC | 1 |
| Chester, AH | 1 |
| Meiltz, A | 1 |
| Kucera, P | 1 |
| de Ribaupierre, Y | 1 |
| Raddatz, E | 1 |
| Yotsumoto, G | 1 |
| Moriyama, Y | 1 |
| Yamaoka, A | 1 |
| Taira, A | 1 |
| Ozüner, Z | 1 |
| Doğan, R | 3 |
| Sarigül, A | 2 |
| Isbir, S | 2 |
| Farsak, B | 3 |
| Tuncer, M | 2 |
| Kilinç, K | 2 |
| Demircin, M | 1 |
| Liu, K | 1 |
| Sekine, S | 1 |
| Goto, Y | 1 |
| Iijima, K | 1 |
| Kondon, K | 1 |
| Matsukawa, M | 1 |
| Tian, J | 1 |
| Wu, W | 1 |
| Zhang, B | 1 |
| Chen, L | 1 |
| Zhang, H | 1 |
| Zhang, X | 1 |
| Zhao, H | 1 |
| Song, X | 1 |
| Han, G | 1 |
| Cisowski, M | 1 |
| Bochenek, A | 1 |
| Kucewicz, E | 1 |
| Wnuk-Wojnar, AM | 1 |
| Morawski, W | 1 |
| Skalski, J | 1 |
| Grzybek, H | 1 |
| Voigtländer, J | 1 |
| Mühlbayer, D | 1 |
| Bernard, M | 1 |
| Caus, T | 1 |
| Sciaky, M | 1 |
| Lan, C | 1 |
| Cozzone, PJ | 1 |
| Schäfer, C | 1 |
| Ladilov, YV | 1 |
| Siegmund, B | 1 |
| Piper, HM | 1 |
| Isbir, CS | 1 |
| Ayd1n, M | 1 |
| Stowe, DF | 1 |
| Heisner, JS | 1 |
| An, J | 1 |
| Camara, A | 1 |
| Varadarajan, SG | 1 |
| Novalija, E | 1 |
| Chen, Q | 1 |
| Schelling, P | 1 |
| Schmiedl, A | 2 |
| Richter, J | 2 |
| Yacoub, M | 2 |
| Shibata, T | 2 |
| Yamamoto, F | 2 |
| Ohashi, T | 2 |
| Nakajima, N | 1 |
| Kinoshita, H | 1 |
| Kawashima, Y | 2 |
| Yamamoto, H | 1 |
| Ichikawa, H | 1 |
| Ishikawa, T | 1 |
| Kagisaki, K | 1 |
| Kumada, Y | 1 |
| Iannettoni, MD | 2 |
| Bove, EL | 4 |
| Fox, MH | 2 |
| Groh, MA | 1 |
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| Braimbridge, MV | 7 |
| Qiu, Y | 2 |
| Breda, MA | 1 |
| Drinkwater, DC | 1 |
| Laks, H | 1 |
| Bhuta, S | 1 |
| Ho, B | 1 |
| Kaczer, E | 1 |
| Sebastian, JL | 1 |
| Chang, P | 1 |
| Bullough, D | 2 |
| Mullane, KM | 2 |
| Ezrin, A | 1 |
| Hori, M | 1 |
| Kitakaze, M | 1 |
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| Takashima, S | 1 |
| Iwakura, K | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095] | Phase 2 | 110 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 20 |
| Cold Blood Cardioplegia | 24 |
CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 6.0 |
| Cold Blood Cardioplegia | 7.8 |
CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 1.9 |
| Cold Blood Cardioplegia | 2.6 |
Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 24 |
| Cold Blood Cardioplegia | 30 |
Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 5.7 |
| Cold Blood Cardioplegia | 7.8 |
Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3.0 |
| Cold Blood Cardioplegia | 4.8 |
Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | .03 |
| Cold Blood Cardioplegia | .03 |
Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 18.8 |
| Cold Blood Cardioplegia | 22.2 |
Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 9.65 |
| Cold Blood Cardioplegia | 10.15 |
LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery
| Intervention | % LV volume (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | -0.06 |
| Cold Blood Cardioplegia | 1.9 |
Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | minutes (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 340 |
| Cold Blood Cardioplegia | 582 |
Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission
| Intervention | days (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3 |
| Cold Blood Cardioplegia | 3 |
Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 47 |
| Cold Blood Cardioplegia | 43 |
time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | hours (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 10.5 |
| Cold Blood Cardioplegia | 11.4 |
2 reviews available for hydrogen carbonate and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
The electrogenic sodium bicarbonate cotransporter and its roles in the myocardial ischemia-reperfusion induced cardiac diseases.
Topics: Acidosis; Animals; Astrocytes; Bicarbonates; Coronary Artery Disease; Heart; Heart Diseases; Humans; | 2021 |
Aprotinin and preservation of myocardial function after ischemia-reperfusion injury.
Topics: Animals; Aprotinin; Bicarbonates; Calcium Chloride; Coronary Artery Bypass; Fibrinolysis; Humans; Ma | 2003 |
7 trials available for hydrogen carbonate and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Morphometric evaluation on myocardial protection of cold crystalloid versus warm blood cardioplegia.
Topics: Bicarbonates; Blood; Body Temperature; Calcium Chloride; Cardioplegic Solutions; Cardiopulmonary Byp | 1995 |
Myocardial protection of cold crystalloid and warm blood cardioplegia. A comparative study.
Topics: Adult; Aortic Valve; Bicarbonates; Blood; Body Temperature; Calcium Chloride; Cardiopulmonary Bypass | 1994 |
Effects of two different crystalloid cardioplegic solutions assessed by myocardial pH, tissue lactate content and energy metabolism.
Topics: Acid-Base Equilibrium; Aged; Bicarbonates; Biopsy; Calcium Chloride; Cardioplegic Solutions; Energy | 1996 |
Warm blood hyperkalaemic reperfusion ('hot shot') prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgery.
Topics: Adenosine Triphosphate; Amino Acids; Bicarbonates; Blood; Calcium Chloride; Cardioplegic Solutions; | 1998 |
The use of exogenous creatine phosphate for myocardial protection in patients undergoing coronary artery bypass surgery.
Topics: Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardiotonic Agents; Coronary Artery Bypass; | 1996 |
Creatine phosphate (Neoton) as an additive to St. Thomas' Hospital cardioplegic solution (Plegisol). Results of a clinical study.
Topics: Adult; Aged; Aorta; Arrhythmias, Cardiac; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Co | 1991 |
Comparison of standard (non-oxygenated) vs. oxygenated St. Thomas' Hospital cardioplegic solution No. 2 (Plegisol).
Topics: Adolescent; Adult; Aged; Bicarbonates; Biopsy; Calcium Chloride; Coronary Artery Bypass; Creatine Ki | 1990 |
83 other studies available for hydrogen carbonate and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
An intact small animal model of myocardial ischemia-reperfusion: Characterization of metabolic changes by hyperpolarized 13C MR spectroscopy.
Topics: Alanine; Animals; Bicarbonates; Carbon Isotopes; Disease Models, Animal; Hemodynamics; Inflammation; | 2015 |
Myocardial protection: efficacy of a novel magnesium-based cardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dose-Response Relationship, Drug; D | 2008 |
eComment: myocardial protection: efficacy of a novel magnesium-basedcardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dose-Response Relationship, Drug; D | 2008 |
Mechanoenergetic function and troponin T release following cardioplegic arrest induced by St Thomas' and histidine-tryptophan-ketoglutarate cardioplegia--an experimental comparative study in pigs.
Topics: Animals; Bicarbonates; Biomarkers; Calcium Chloride; Cardioplegic Solutions; Cardiopulmonary Bypass; | 2009 |
New strategy of endothelial protection in cardiac surgery: use of enhancer of endothelial nitric oxide synthase.
Topics: Animals; Arginine; Benzodioxoles; Bicarbonates; Blotting, Western; Bradykinin; Calcium Chloride; Car | 2010 |
Ischaemic postconditioning: does cardioplegia influence protection?
Topics: Animals; Bicarbonates; Calcium Chloride; Coronary Circulation; Disease Models, Animal; Heart Arrest, | 2012 |
Editorial comment: myocardial protection with postconditioning in cardiac surgery: the importance of the model.
Topics: Animals; Bicarbonates; Calcium Chloride; Heart Arrest, Induced; Ischemic Postconditioning; Magnesium | 2012 |
Deleterious effect of hypothermia in myocardial protection against cold ischemia: a comparative study in isolated rat hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cold Ischemia; Disaccharides; Edema | 2012 |
Initial reperfusion with magnesium after cardioplegic arrest attenuates myocardial reperfusion injury.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine Kinase; Glucose; Guinea Pi | 2002 |
Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Bicarbonates; Cardioplegic Solutions; He | 2002 |
Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas' hospital cardioplegic solutions used for myocardial preservation in isolated guinea pig hearts.
Topics: Amrinone; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardiotonic Agents; Enoxi | 2002 |
K(ATP) channel opener protects neonatal rabbit heart better than St. Thomas' solution.
Topics: Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulat | 2003 |
Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation.
Topics: Adenosine; Animals; Bicarbonates; Blood Flow Velocity; Body Water; Calcium Chloride; Cardioplegic So | 2004 |
Effect of hypoxia-reoxygenation on endothelial function in porcine cardiac microveins.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bicarbonates; Biologica | 2006 |
Mechanisms of cardiodepression by an Na+-H+ exchange inhibitor methyl-N-isobutyl amiloride (MIA) on the heart: lack of beneficial effects in ischemia-reperfusion injury.
Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Bicarbonates; Calcium; Calcium-Transporting ATPases; Car | 2007 |
Human recombinant extracellular-superoxide dismutase type C improves cardioplegic protection against ischemia/reperfusion injury in isolated rat heart.
Topics: Animals; Bicarbonates; Calcium Chloride; Cattle; Hemodynamics; Humans; In Vitro Techniques; Ischemia | 1994 |
Comparison of single- and multi-dose crystalloid cardioplegia to protect the immature myocardium.
Topics: Analysis of Variance; Animals; Animals, Newborn; Bicarbonates; Cardioplegic Solutions; Coronary Circ | 1994 |
Protection of the chronic hypoxic immature rat heart during global ischemia.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Blood Gas Analysis; Calcium Chloride; Cardioplegic So | 1995 |
Ischemic preconditioning, cardioplegia or both?
Topics: Animals; Bicarbonates; Calcium Chloride; Coronary Circulation; Heart Arrest, Induced; Magnesium; Mal | 1994 |
Tolerance of the developing heart to ischemia: impact of hypoxemia from birth.
Topics: Age Factors; Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Crea | 1995 |
Stunning, preconditioning, and functional recovery after global myocardial ischemia.
Topics: Animals; Bicarbonates; Blood Pressure; Calcium Chloride; Cardioplegic Solutions; Heart Arrest, Induc | 1994 |
Experimental evaluation of Celsior, a new heart preservation solution.
Topics: Abdomen; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cold Temperature; Disaccha | 1994 |
Isolated in-vitro perfusion of pig hearts obtained from the abattoir: an alternative to animal experiments?
Topics: Abattoirs; Animal Testing Alternatives; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Soluti | 1994 |
Myocardial protection during prolonged ischaemic cardiac arrest: experimental evaluation of three crystalloid cardioplegic solutions.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Electrolytes; Evaluation Studies as | 1994 |
Interactions between preischemic hypothermia and cardioplegic solutions in the neonatal lamb heart.
Topics: Animals; Animals, Newborn; Bicarbonates; Calcium; Calcium Chloride; Cardioplegic Solutions; Glucose; | 1994 |
Intracellular catalase inhibition does not predispose rat heart to ischemia-reperfusion and hydrogen peroxide-induced injuries.
Topics: Amitrole; Animals; Bicarbonates; Cardiomyopathies; Cardioplegic Solutions; Catalase; Coronary Circul | 1993 |
Protective effects of diltiazem and ryanodine against ischemia-reperfusion injury in neonatal rabbit hearts.
Topics: Animals; Animals, Newborn; Bicarbonates; Blood Pressure; Calcium Chloride; Cardioplegic Solutions; C | 1993 |
Role of catalase and heat shock protein on recovery of cardiac endothelial and mechanical function after ischemia.
Topics: Amitrole; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Catalase; Endothelium, Va | 1993 |
Mechanisms of antifibrillatory effect of acidic reperfusion: role of perfusate bicarbonate concentration.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Buffers; Coronary Circulation; Heart Rate; Heart Ventri | 1993 |
Improvement of cardiac function impaired by repeated ischemic arrests in isolated rat hearts.
Topics: Animals; Aorta; Bicarbonates; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Coenzymes; C | 1993 |
Zinc supplementation enhances the effectiveness of St. Thomas' Hospital No. 2 cardioplegic solution in an in vitro model of hypothermic cardiac arrest.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Heart Arrest, Induced; Hypothermia, | 1995 |
Myocardial protection with potassium-channel openers is as effective as St. Thomas' solution in the rabbit heart.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Ci | 1996 |
Functional, metabolic and ultrastructure evidence for improved myocardial protection during severe ischaemic stress with MBS, a new crystalloid cardioplegic solution.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Bicarbonates; Calcium Chloride; Cardioplegic Solutio | 1996 |
Impact of extracellular buffer composition on cardioprotective efficacy of Na+/H+ exchanger inhibitors.
Topics: Amiloride; Animals; Bicarbonates; Buffers; Dose-Response Relationship, Drug; Extracellular Space; Gu | 1996 |
Adverse effects of crystalloid cardioplegia and slow cooling for protection of immature rat hearts.
Topics: Adenosine Triphosphate; Age Factors; Animals; Bicarbonates; Calcium Chloride; Cardiomegaly; Cardiopl | 1996 |
Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy.
Topics: Acidosis; Adenosine Triphosphate; Amiloride; Animals; Bicarbonates; Calcium; Calcium Chloride; Cardi | 1996 |
High cardioplegic perfusion pressure entails reduced myocardial recovery.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardiopulmo | 1997 |
Effect of ischaemia and reperfusion on the intracellular concentration of taurine and glutamine in the hearts of patients undergoing coronary artery surgery.
Topics: Adenosine Triphosphate; Aged; Bicarbonates; Biomarkers; Blood; Calcium Chloride; Cardioplegic Soluti | 1997 |
Effect of cardioplegia infusion pressure on coronary artery endothelium and cardiac mechanical function.
Topics: Animals; Barotrauma; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Vessels; Endot | 1997 |
Inhibition of endogenous endothelin during cardioplegia improves low coronary reflow following prolonged hypothermic arrest.
Topics: Animals; Bicarbonates; Bosentan; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; End | 1997 |
Inhibition of bicarbonate transport protects embryonic heart against reoxygenation-induced dysfunction.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acidosis; Amiloride; Animals; Arrhythmias, Cardiac | 1998 |
Experimental study of cardiac lymph dynamics and edema formation in ischemia/reperfusion injury--with reference to the effect of hyaluronidase.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Body Temperature; Body Water; Calcium Chloride; Cardi | 1998 |
Human albumin enriched St. Thomas Hospital cardioplegic solution increases reperfusion injury in isolated perfused rat hearts.
Topics: Albumins; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Fem | 1998 |
Beneficial effect of captopril against ischaemia-reperfusion injury in isolated guinea pig hearts.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chlor | 1998 |
Experimental study on the scavenging effects of ginsenosides on oxygen free radicals using model of heterotopic heart transplantation in rats.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Disease Models, Animal; Female; Fre | 1998 |
No beneficial effects of isocolloidoosmotic synthetic colloid addition to St. Thomas Hospital cardioplegic solution in ischemia-reperfusion injury in isolated perfused rat hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Colloids; Female; Magnesium; Male; | 1999 |
Efficacy of contraction uncoupling by 2,3-butanedione monoxime during initial reperfusion versus cardioplegic arrest for protection of isolated hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Diacetyl; Gui | 1999 |
Optimized cardiac graft preservation: a comparative experimental study using P-31 magnetic resonance spectroscopy and biochemical analyses.
Topics: Acid-Base Equilibrium; Adenosine; Adenosine Triphosphate; Allopurinol; Amino Acids; Animals; Bicarbo | 1999 |
Importance of bicarbonate transport for protection of cardiomyocytes against reoxygenation injury.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anti-Arrhythmia Agents; Bicarbonates; Cal | 2000 |
The effect of captopril on membrane bound enzymes in ischemia-reperfusion injury.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chloride; Captopril; Cardio | 2000 |
Protective effect of lisinopril against ischemia-reperfusion injury in isolated guinea pig hearts.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chlor | 2001 |
Myocardial protection: the efficacy of an ultra-short-acting beta-blocker, esmolol, as a cardioplegic agent.
Topics: Adrenergic beta-Antagonists; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Constr | 2001 |
Inhibition of Na(+)/H(+) isoform-1 exchange protects hearts perfused after 6-hour cardioplegic cold storage.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Guanidines; G | 2002 |
Different preservation of myocardial capillary endothelial cells and cardiomyocytes during and after cardioplegic ischemia (25 degrees C) of canine hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Endothelium, Vascular; Female | 2002 |
Detrimental effects of temperature on the efficacy of the University of Wisconsin solution when used for cardioplegia at moderate hypothermia. Comparison with the St. Thomas Hospital solution at 4 degrees C and 20 degrees C.
Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Endothelium | 1992 |
[The effects of protease inhibitor upon the ischemia-reperfusion injury].
Topics: Animals; Benzamidines; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Guanidines; Magnesium | 1992 |
[The effects of potassium concentration in reperfusion solution upon myocardial protection].
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine Kinase; Dose-Response Rela | 1992 |
The effect of intramyocardial pH on functional recovery in neonatal hearts receiving St. Thomas' Hospital cardioplegic solution during global ischemia.
Topics: Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Hemodynamics; His | 1992 |
Transient hypocalcemic reperfusion does not improve postischemic recovery in the rat heart after preservation with St. Thomas' Hospital cardioplegic solution.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium; Calcium Chloride; Cardioplegic Solutions; Cr | 1992 |
Comparison of ischemic vulnerability and responsiveness to cardioplegic protection in crystalloid-perfused versus blood-perfused hearts.
Topics: Animals; Bicarbonates; Blood; Calcium Chloride; Cardioplegic Solutions; Female; Magnesium; Male; Myo | 1992 |
Successful long-term preservation of the neonatal heart with a modified intracellular solution.
Topics: Adenosine; Allopurinol; Animals; Animals, Newborn; Bicarbonates; Cardioplegic Solutions; Glucose; Gl | 1992 |
Exogenous adenosine accelerates recovery of cardiac function and improves coronary flow after long-term hypothermic storage and transplantation.
Topics: Abdomen; Adenosine; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circul | 1992 |
Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart.
Topics: Abdomen; Adenine Nucleotides; Adenosine; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium | 1992 |
Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat.
Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium Chloride; Cardiopleg | 1992 |
PEG-SOD and myocardial protection. Studies in the blood- and crystalloid-perfused rabbit and rat hearts.
Topics: Animals; Bicarbonates; Blood; Calcium Chloride; Cardioplegic Solutions; Crystalloid Solutions; Dose- | 1992 |
Staged reperfusion attenuates myocardial stunning in dogs. Role of transient acidosis during early reperfusion.
Topics: Acidosis; Adenosine Triphosphate; Animals; Bicarbonates; Calcium; Dogs; Hydrochloric Acid; Hydrogen- | 1991 |
Protection of immature myocardium by the addition of mannitol to crystalloid cardioplegic solution.
Topics: Adenosine Triphosphate; Adult; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs | 1991 |
Enhanced myocardial protection during global ischemia with 5'-nucleotidase inhibitors.
Topics: 5'-Nucleotidase; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dimethyl Sulfoxide | 1992 |
Perfusate calcium: effect on cardiac stability and response to ischemia and reperfusion.
Topics: Animals; Bicarbonates; Buffers; Calcium; Calcium Chloride; Cardioplegic Solutions; Magnesium; Male; | 1991 |
The effect of high buffer cardioplegia and secondary cardioplegia on cardiac preservation and postischemic functional recovery: a 31P NMR and functional study in Langendorff perfused pig hearts.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Buffers; Calcium; Calcium Chloride; Cardioplegic Solu | 1991 |
St. Thomas' Hospital cardioplegic solution. Beneficial effect of glucose and multidose reinfusions of cardioplegic solution.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dose-Response Relationship, Drug; G | 1991 |
Patterns of structural deterioration due to ischemia in Purkinje fibres and different layers of the working myocardium.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Endocardium; Glucose; Heart A | 1991 |
Species differences in susceptibility to ischemic injury and responsiveness to myocardial protection.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine Kinase; Energy Metabolism; | 1990 |
Prolonged cardiac preservation. Evaluation of the University of Wisconsin preservation solution by comparison with the St. Thomas' Hospital cardioplegic solutions in the rat.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cardioplegi | 1990 |
Cardioplegia-induced damage to ischemic immature myocardium is independent of oxygen availability.
Topics: Animals; Bicarbonates; Buffers; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Coronary C | 1990 |
Assessment of ischemic injury and protective interventions: the Langendorff versus the working rat heart preparation.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Disease; Heart; Magnesium; | 1990 |
The concentration of calcium in neonatal cardioplegia.
Topics: Animals; Animals, Newborn; Bicarbonates; Calcium; Calcium Chloride; Cardioplegic Solutions; Heart Ar | 1990 |
Free radicals and cardioplegia: organic anti-oxidants as additives to the St Thomas' Hospital cardioplegic solution.
Topics: Animals; Antioxidants; Ascorbic Acid; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardio | 1989 |
[Ischemic-reperfusion injury of the heart: comparison of intra- and extracellular types of cardioplegic solutions].
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Glucose; In Vitro Techniques; Magne | 1989 |
Cardioplegia: relation of myocardial protection to infusion volume and duration.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Heart; Heart Arrest | 1989 |
Enhanced myocardial protection with adenosine.
Topics: Adenosine; Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; | 1989 |
Age-related changes in the ability of hypothermia and cardioplegia to protect ischemic rabbit myocardium.
Topics: Aging; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Heart; | 1988 |
Optimal myocardial protection during crystalloid cardioplegia. Interrelationship between volume and duration of infusion.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Heart Arrest, Induc | 1988 |