hydrogen carbonate and Hypocalcemia studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"Hypocalcemia is not commonly observed following ethylene glycol poisoning, even in acidotic patients."	7.85	Serum Calcium Concentration in Ethylene Glycol Poisoning. ( Grant, W; Hodgman, M; Marraffa, JM; Wojcik, S, 2017)
"Hypocalcemia was believed to be the result of aggressive sodium bicarbonate treatment for a cat with aspirin intoxication."	7.67	Hypocalcemia associated with administration of sodium bicarbonate for salicylate intoxication in a cat. ( Abrams, KL, 1987)
"Hypocalcemia has been suggested as a clue supporting the diagnosis of EG poisoning in patients presenting with an unexplained high anion gap metabolic acidosis (HAGMA)."	5.91	Assessing the Role of Initial Serum Calcium Concentration in Patients with Ethylene Glycol Poisoning. ( Hodgman, MJ; Howland, MA; Marraffa, JM; Mercurio-Zappala, M; Stork, C; Su, M; Wiener, BG, 2023)
"Patients with acute renal failure or chronic renal failure treated with renal replacement therapy were excluded from this study."	5.32	[Prevalence of anemia, calcium-phosphorus abnormalities and metabolic acidosis in different stages of chronic renal failure]. ( Chudek, J; Kokot, F; Kopeć, P; Kukla, M; Mamcarz, E; Wiecek, A; Wnuk, Z; Zarzecki, M, 2004)
"Hypocalcemia is not commonly observed following ethylene glycol poisoning, even in acidotic patients."	3.85	Serum Calcium Concentration in Ethylene Glycol Poisoning. ( Grant, W; Hodgman, M; Marraffa, JM; Wojcik, S, 2017)
"Hypocalcemia was believed to be the result of aggressive sodium bicarbonate treatment for a cat with aspirin intoxication."	3.67	Hypocalcemia associated with administration of sodium bicarbonate for salicylate intoxication in a cat. ( Abrams, KL, 1987)
"Using predictive Q(Ca) dosing and integrating control of the infusion pumps with the dialysis machine, SLED-RCA can be near-automated today to provide a user-friendly and safe system."	2.46	Automated regional citrate anticoagulation: technological barriers and possible solutions. ( Frinak, S; Szamosfalvi, B; Yee, J, 2010)
"Hypocalcemia has been suggested as a clue supporting the diagnosis of EG poisoning in patients presenting with an unexplained high anion gap metabolic acidosis (HAGMA)."	1.91	Assessing the Role of Initial Serum Calcium Concentration in Patients with Ethylene Glycol Poisoning. ( Hodgman, MJ; Howland, MA; Marraffa, JM; Mercurio-Zappala, M; Stork, C; Su, M; Wiener, BG, 2023)
"Patients with acute renal failure or chronic renal failure treated with renal replacement therapy were excluded from this study."	1.32	[Prevalence of anemia, calcium-phosphorus abnormalities and metabolic acidosis in different stages of chronic renal failure]. ( Chudek, J; Kokot, F; Kopeć, P; Kukla, M; Mamcarz, E; Wiecek, A; Wnuk, Z; Zarzecki, M, 2004)
"Hypocalcemia is common and hypophosphatemia is not infrequent."	1.26	The metabolic and respiratory alterations of heat stroke. ( Fernaine, AV; Portocarrero, CJ; Sprung, CL; Weinberg, PF, 1980)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (73.47)	18.7374
1990's	1 (2.04)	18.2507
2000's	4 (8.16)	29.6817
2010's	6 (12.24)	24.3611
2020's	2 (4.08)	2.80

Authors	Studies
Hodgman, MJ	1
Marraffa, JM	2
Wiener, BG	1
Howland, MA	1
Stork, C	1
Mercurio-Zappala, M	1
Su, M	1
Boisen, IM	1
Rehfeld, A	1
Mos, I	1
Poulsen, NN	1
Nielsen, JE	1
Schwarz, P	1
Rejnmark, L	1
Dissing, S	1
Bach-Mortensen, P	1
Juul, A	1
Bräuner-Osborne, H	1
Lanske, B	1
Blomberg Jensen, M	1
Chazot, C	1
Jean, G	1
Joly, D	1
Wilson, FP	1
Berns, JS	1
Hodgman, M	1
Wojcik, S	1
Grant, W	1
Szamosfalvi, B	1
Frinak, S	1
Yee, J	1
Ho, KM	1
Leonard, A	1
Morris, LF	1
Loh, C	1
Ro, K	1
Wiseman, JE	1
Gomes, AS	1
Asandra, A	1
Wariri, S	1
Yeh, MW	1
BOEN, ST	1
FUJITA, T	1
ORIMO, H	1
YOSHIKAWA, M	1
MORIL, H	1
NAKAO, K	1
Qunibi, WY	1
Hootkins, RE	1
McDowell, LL	1
Meyer, MS	1
Simon, M	1
Garza, RO	1
Pelham, RW	1
Cleveland, MV	1
Muenz, LR	1
He, DY	1
Nolan, CR	1
Zarzecki, M	1
Chudek, J	1
Kukla, M	1
Kopeć, P	1
Mamcarz, E	1
Wnuk, Z	1
Kokot, F	1
Wiecek, A	1
Remer, T	1
Berkemeyer, S	1
Fox, GN	1
Stevens, JB	1
Olson, WG	1
Caprilli, R	1
Vernia, P	1
Colaneri, O	1
Frieri, G	1
Rouse, D	1
Sessoms, S	1
Stinebaugh, BJ	1
Suki, WN	1
Agus, ZS	1
Goldfarb, S	1
Sprung, CL	1
Portocarrero, CJ	1
Fernaine, AV	1
Weinberg, PF	1
Ten Harkel, AD	1
Kist-Van Holthe, JE	1
Van Weel, M	1
Van der Vorst, MM	1
Ringe, JD	1
Nervez, CT	1
Shott, RJ	1
Bergstrom, WH	1
Williams, ML	1
Eckart, J	1
Schaaf, H	1
Wiberg, JJ	1
Turner, GG	1
Nuttall, FQ	1
Madsen, S	1
Olgaard, K	1
Ladefoged, J	1
Torelli, M	1
Masciale, A	1
Pisano, R	1
Tsang, RC	2
Gigger, M	1
Oh, W	1
Brown, DR	1
Banister, A	1
Matin-Siddiqi, SA	1
Hatcher, GW	1
Boles, C	1
Di Lorenzo, R	1
Bernardi, M	1
Genedani, S	1
Zirilli, E	1
Grossi, G	1
Guaraldi, GP	1
Bertolini, A	1
Patel, R	1
Benjamin, J	1
Abrams, KL	1
Rocher, LL	1
Tannen, RL	1
Abitbol, A	1
Abate, CD	1
Arias, A	1
Cusimano, L	1
Guzzo, C	1
Knapp, MS	1
Gough, KR	1
Newman, CG	1
Wilson, BD	1
Callaghan, P	1
Young, L	1
Cortese, AF	1
Glenn, F	1
Kleeman, CR	1
Better, OS	1
Hotz, J	1
Minne, H	1
Ziegler, R	1
Cochran, M	2
Bulusu, L	1
Horsman, A	1
Stasiak, L	1
Nordin, BE	2
Lieberman, E	1
Chen, I	1
Hayes, W	1
Atkinson, W	1
Atherton, H	1
Edwards, N	1
Hallauer, W	1
Schirmeister, J	1
Radde, IC	1
Parkinson, DK	1
Höffken, B	1
Appiah, KE	1
Hanley, WB	1
Heidbreder, E	1
Hennemann, H	1
Krempien, B	1
Heidland, A	1
Emerson, TE	1
Scott, JB	1
Haddy, FJ	1
Rampini, S	1
Fanconi, A	1
Illig, R	1
Prader, A	1
Kaplan, SA	1

Article	Year
[Metabolic complications of chronic kidney disease]. Nephrologie & therapeutique, 2017, Volume: 13, Issue:6S Topics: Acidosis; Aged; Aged, 80 and over; Bicarbonates; Bradycardia; Calcium; Calcium, Dietary; Comorbidity	2017
Tumor lysis syndrome: new challenges and recent advances. Advances in chronic kidney disease, 2014, Volume: 21, Issue:1 Topics: Acute Kidney Injury; Allopurinol; Bicarbonates; Buffers; Calcium; Diuretics; Enzyme Inhibitors; Febu	2014
Automated regional citrate anticoagulation: technological barriers and possible solutions. Blood purification, 2010, Volume: 29, Issue:2 Topics: Anticoagulants; Automation; Bicarbonates; Calcium; Chelating Agents; Citric Acid; Equipment Design;	2010
[Problems in massive transfusion]. Infusionstherapie und klinische Ernahrung, 1978, Volume: 5, Issue:6 Topics: Acid-Base Imbalance; Bicarbonates; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Pre	1978
The clinical spectrum of renal tubular acidosis. Annual review of medicine, 1986, Volume: 37 Topics: Acidosis, Renal Tubular; Adult; Aldosterone; Ammonium Chloride; Animals; Bicarbonates; Bone Diseases	1986
Disordered divalent ion metabolism in kidney disease: comments on pathogenesis and treatment. Kidney international, 1973, Volume: 4, Issue:2 Topics: Bicarbonates; Bone Resorption; Calcium; Cholecalciferol; Chronic Kidney Disease-Mineral and Bone Dis	1973
[Disorders of water-electrolyte blaance in kidney diseases]. Der Landarzt, 1968, Oct-20, Volume: 44, Issue:29 Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Acute Kidney Injury; Anuria; Bicarbonates; Chlorides	1968

Article	Year
Assessing the Role of Initial Serum Calcium Concentration in Patients with Ethylene Glycol Poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2023, Volume: 19, Issue:4 Topics: Acidosis; Bicarbonates; Calcium; Creatinine; Ethylene Glycol; Humans; Hypocalcemia; Poisoning; Retro	2023
The Calcium-Sensing Receptor Is Essential for Calcium and Bicarbonate Sensitivity in Human Spermatozoa. The Journal of clinical endocrinology and metabolism, 2021, 03-25, Volume: 106, Issue:4 Topics: Acrosome Reaction; Adult; Bicarbonates; Calcium; Calcium Signaling; Case-Control Studies; Female; Hu	2021
Serum Calcium Concentration in Ethylene Glycol Poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2017, Volume: 13, Issue:2 Topics: Acid-Base Equilibrium; Acidosis; Adult; Bicarbonates; Biomarkers; Blood Gas Analysis; Calcium; Down-	2017
Risk factors and outcome associated with hypomagnesemia in massive transfusion. Transfusion, 2011, Volume: 51, Issue:2 Topics: Adult; Aged; APACHE; Bicarbonates; Blood Transfusion; Burns; Confounding Factors, Epidemiologic; Ery	2011
Non-super-selective venous sampling for persistent hyperparathyroidism using a systemic hypocalcemic challenge. Journal of vascular and interventional radiology : JVIR, 2012, Volume: 23, Issue:9 Topics: Adenoma; Adolescent; Adult; Aged; Aged, 80 and over; Bicarbonates; Biomarkers; Calcium; Catheterizat	2012
[CLINICAL SIGNIFICANCE OF VARIATIONS IN THE ELECTROLYTE CONCENTRATION OF THE SERUM]. Nederlands tijdschrift voor geneeskunde, 1964, Feb-15, Volume: 108 Topics: Bicarbonates; Calcium; Calcium, Dietary; Carbon Dioxide; Chlorides; Electrolytes; Humans; Hypercalce	1964
EFFECT OF ACIDOSIS AND ALKALOSIS ON RECOVERY FROM HYPOCALCEMIA. Endocrinology, 1965, Volume: 76 Topics: Acidosis; Alkalosis; Animals; Bicarbonates; Dogs; Endocrinology; Hypocalcemia; Oxalates; Parathyroid	1965
[Prevalence of anemia, calcium-phosphorus abnormalities and metabolic acidosis in different stages of chronic renal failure]. Polskie Archiwum Medycyny Wewnetrznej, 2004, Volume: 112, Issue:4 Topics: Acidosis; Acidosis, Renal Tubular; Adult; Aged; Anemia, Hypochromic; Bicarbonates; Biomarkers; Calci	2004
Letter re: Persistent hypocalciuric effect of potassium bicarbonate in postmenopausal women. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:8 Topics: Bicarbonates; Calcium; Female; Humans; Hypocalcemia; Middle Aged; Postmenopause; Potassium Compounds	2005
Hypocalcemia complicating bicarbonate therapy for salicylate poisoning. The Western journal of medicine, 1984, Volume: 141, Issue:1 Topics: Acid-Base Equilibrium; Adolescent; Aspirin; Bicarbonates; Calcium; Humans; Hypocalcemia; Male; Sodiu	1984
Free fatty acid-induced hypocalcemia in food-deprived dairy cattle. American journal of veterinary research, 1984, Volume: 45, Issue:11 Topics: Animals; Bicarbonates; Calcium; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female; Food De	1984
Risk factors in toxic megacolon. Digestive diseases and sciences, 1980, Volume: 25, Issue:11 Topics: Adult; Beta-Globulins; Bicarbonates; Colitis, Ulcerative; Humans; Hypocalcemia; Hypokalemia; Hypopro	1980
The effect of hypocalcemia on renal bicarbonate absorption. Mineral and electrolyte metabolism, 1984, Volume: 10, Issue:1 Topics: Animals; Bicarbonates; Calcium; Dogs; Egtazic Acid; Female; Hypocalcemia; Kidney; Male; Parathyroid	1984
Clinical disorders of calcium and phosphate. The Medical clinics of North America, 1981, Volume: 65, Issue:2 Topics: Bicarbonates; Biological Transport; Calcitonin; Humans; Hypercalcemia; Hypocalcemia; Kidney; Phospha	1981
The metabolic and respiratory alterations of heat stroke. Archives of internal medicine, 1980, Volume: 140, Issue:5 Topics: Acidosis; Adult; Aged; Bicarbonates; Calcium; Female; Heat Exhaustion; Humans; Hypocalcemia; Lactate	1980
Alkalinization and the tumor lysis syndrome. Medical and pediatric oncology, 1998, Volume: 31, Issue:1 Topics: Adolescent; Bicarbonates; Fluid Therapy; Furosemide; Humans; Hypocalcemia; Lymphoma, Non-Hodgkin; Ma	1998
[Risk of osteoporosis by over-acidification of the organism and possible treatment by alkalizing therapy?]. Deutsche medizinische Wochenschrift (1946), 2001, Mar-16, Volume: 126, Issue:11 Topics: Acidosis; Bicarbonates; Calcium, Dietary; Female; Humans; Hypocalcemia; Male; Osteoporosis; Osteopor	2001
Prophylaxis against hypocalcemia in low-birth-weight infants requiring bicarbonate infusion. The Journal of pediatrics, 1975, Volume: 87, Issue:3 Topics: Bicarbonates; Birth Weight; Calcium; Female; Glucose; Humans; Hydrogen-Ion Concentration; Hypocalcem	1975
Effect of phosphate or magnesium cathartics on serum calcium: observations in normocalcemic patients. Archives of internal medicine, 1978, Volume: 138, Issue:7 Topics: Barium Sulfate; Bicarbonates; Calcium; Cathartics; Chlorides; Enema; Humans; Hypocalcemia; Magnesium	1978
Renal handling of phosphate in relation to serum parathyroid hormone levels. Acta medica Scandinavica, 1976, Volume: 200, Issue:1-2 Topics: Adult; Bicarbonates; Female; Glomerular Filtration Rate; Humans; Hypercalcemia; Hypocalcemia; Kidney	1976
[Hypocalcemia in newborn infants with respiratory syndrome treated with sodium bicarbonate. Therapeutic considerations]. La Pediatria, 1976, Sep-30, Volume: 84, Issue:3 Topics: Acidosis, Respiratory; Bicarbonates; Gluconates; Humans; Hypocalcemia; Infant, Newborn; Infant, Newb	1976
Studies in calcium metabolism in infants with intrauterine growth retardation. The Journal of pediatrics, 1975, Volume: 86, Issue:6 Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Asphyxia Neonatorum; Bicarbonates; Birth Weight; Blood	1975
Treatment of hypernatraemic dehydration in infancy. Archives of disease in childhood, 1975, Volume: 50, Issue:3 Topics: Bicarbonates; Body Weight; Dehydration; Gastroenteritis; Humans; Hyperglycemia; Hypernatremia; Hypoc	1975
Post-operative management of equine abdominal patients. Journal of the South African Veterinary Association, 1975, Volume: 46, Issue:1 Topics: Abdomen; Animals; Bicarbonates; Blood Proteins; Drainage; Gastrointestinal Motility; Hematocrit; Hor	1975
Acute alkalosis, but not acute hypocalcemia, increases panic behavior in an animal model. Physiology & behavior, 1987, Volume: 41, Issue:4 Topics: Alkalosis; Animals; Behavior, Animal; Bicarbonates; Fear; Female; Hypocalcemia; Lactates; Lactic Aci	1987
Renal disease associated with toluene inhalation. Journal of toxicology. Clinical toxicology, 1986, Volume: 24, Issue:3 Topics: Acidosis, Renal Tubular; Adhesives; Adolescent; Adult; Bicarbonates; Calcium Gluconate; Female; Huma	1986
Hypocalcemia associated with administration of sodium bicarbonate for salicylate intoxication in a cat. Journal of the American Veterinary Medical Association, 1987, Jul-15, Volume: 191, Issue:2 Topics: Animals; Aspirin; Bicarbonates; Cat Diseases; Cats; Hypocalcemia; Male; Sodium; Sodium Bicarbonate	1987
Phosphate-induced hypocalcaemia and experimental digitalis intoxication. Cardiovascular research, 1974, Volume: 8, Issue:1 Topics: Animals; Bicarbonates; Calcium; Cardiac Complexes, Premature; Digitalis; Dogs; Electrocardiography;	1974
An unusual neurological manifestation of hypocalcaemia. Lancet (London, England), 1967, Mar-04, Volume: 1, Issue:7488 Topics: Adolescent; Adult; Anemia, Macrocytic; Bicarbonates; Calcium; Ergocalciferols; Female; Folic Acid De	1967
Neonatal death associated with isovalericacidaemia. Lancet (London, England), 1967, Aug-26, Volume: 2, Issue:7513 Topics: Acidosis; Bicarbonates; Chromatography; Chromatography, Gas; Coenzyme A; Electrolytes; Fatty Acids;	1967
Hypocalcemia and tetany with steroid-induced acute pancreatitis. Archives of surgery (Chicago, Ill. : 1960), 1968, Volume: 96, Issue:1 Topics: Acidosis; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Bicarbonates; Calcium; Hemorr	1968
The influences of acute hyper- and hypocalcemia and of calcitonin on exocrine pancreatic function in man. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1973, Volume: 160, Issue:2 Topics: Acute Disease; Adult; Amylases; Bicarbonates; Calcitonin; Cholecystokinin; Female; Humans; Hypercalc	1973
Hypocalcaemia and bone disease in renal failure. Nephron, 1973, Volume: 10, Issue:2 Topics: Absorptiometry, Photon; Acidosis; Adolescent; Adult; Aged; Alkaline Phosphatase; Bicarbonates; Biops	1973
Management of acute renal failure in infants and children. Nephron, 1973, Volume: 11, Issue:2 Topics: Acidosis; Acute Kidney Injury; Anemia; Bicarbonates; Calcium; Child, Preschool; Dehydration; Furosem	1973
Neonatal hypocalcemia in infants with birth asphyxia. The Journal of pediatrics, 1974, Volume: 84, Issue:3 Topics: Apgar Score; Asphyxia Neonatorum; Bicarbonates; Blood; Calcium; Female; Gestational Age; Humans; Hyp	1974
Calcium ion activity in the sick neonate: effect of bicarbonate administration and exchange transfusion. Pediatric research, 1972, Volume: 6, Issue:1 Topics: Acidosis; Bicarbonates; Blood; Blood Proteins; Calcium; Exchange Transfusion, Whole Blood; Humans; H	1972
[Salidiuretic therapy of renal tubular acidosis and its complications]. Deutsche medizinische Wochenschrift (1946), 1972, Oct-06, Volume: 97, Issue:40 Topics: Acidosis, Renal Tubular; Bicarbonates; Biopsy; Blood Chemical Analysis; Blood Gas Analysis; Bone and	1972
Effects of acute multiple changes in plasma electrolyte levels on dog blood pressure. The American journal of physiology, 1970, Volume: 218, Issue:1 Topics: Animals; Bicarbonates; Blood Pressure; Chlorides; Dogs; Female; Heart Rate; Hematocrit; Hydrogen-Ion	1970
The causes of hypocalcaemia in chronic renal failure. Clinical science, 1971, Volume: 40, Issue:4 Topics: Acidosis; Adolescent; Adult; Aged; Bicarbonates; Calcium; Creatinine; Female; Glomerular Filtration	1971
Effect of hydrochlorothiazide on proximal renal tubular acidosis in a patient with idiopathic "de toni-debré-fanconi syndrome". Helvetica paediatrica acta, 1968, Volume: 23, Issue:1 Topics: Acidosis; Adolescent; Bicarbonates; Calcium; Fanconi Syndrome; Female; Humans; Hydrochlorothiazide;	1968
Fluid and electrolyte therapy: maintenance, abnormal states, methods of administration. Pediatric clinics of North America, 1969, Volume: 16, Issue:3 Topics: Acidosis; Bicarbonates; Burns; Child; Child, Preschool; Chlorides; Deficiency Diseases; Homeostasis;	1969

hydrogen carbonate and Hypocalcemia

Research Excerpts

Research

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