hydrogen carbonate and Hypernatremia studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Research Excerpts

Excerpt	Relevance	Reference
"A patient who attempted suicide by ingesting a large amount of phenformin developed a severe lactic acidosis."	7.66	Hemodialysis for phenformin associated lactic acidosis. ( Mookerjee, BK; Tobin, M, 1978)
" Twenty infants (77%) had severe metabolic acidosis and were treated with a combination of sodium bicarbonate and 5% glucose in water until the acidosis was corrected after which a solution of sodium chloride replaced the use of sodium bicarbonate."	3.67	Hypernatraemic dehydration in infants in Kuwait with special reference to therapy of associated metabolic acidosis. ( Fedeczko, D; Fernando, NP; John, AI, 1984)
"To examine the effect of selective rise of plasma NaCl concentration (hypernatremia) on NaHCO3 reabsorption and associated NaCl reabsorption remaining during continuous ethacrynic acid infusion, hypertonic NaCl solution was infused in three groups of anesthetized volume-expanded dogs."	3.67	Hypernatremia inhibits NaHCO3 reabsorption and associated NaCl reabsorption in dogs. ( Hartmann, A; Kiil, F; Langberg, H; Mathisen, O; Ostensen, J, 1986)
"A patient who attempted suicide by ingesting a large amount of phenformin developed a severe lactic acidosis."	3.66	Hemodialysis for phenformin associated lactic acidosis. ( Mookerjee, BK; Tobin, M, 1978)
"Hyperkalemia is produced by redistribution of cellular and extracellular potassium or by increased body potassium."	2.36	Diagnostic strategies in disorders of fluid, electrolyte and acid-base homeostasis. ( Bastl, CP; Jones, ER; Narins, RG; Rudnick, MR; Stom, MC, 1982)
"Her hypernatremia was treated exclusively with oral rehydration salt solution."	1.42	Extreme hypernatremic dehydration due to potential sodium intoxication: consequences and management for an infant with diarrhea at an urban intensive care unit in Bangladesh: a case report. ( Afroze, F; Ahmed, T; Chisti, MJ; Das, SK; Faruque, AS; Huq, S; Islam, MM; Matin, FB; Sarker, SA; Shahrin, L, 2015)
"Two patients with lactic acidosis are described, along with our experience using CAVHD and citrate in other clinical settings."	1.28	Lactic acidosis treated with continuous hemodiafiltration and regional citrate anticoagulation. ( Galishoff, M; Kirschbaum, B; Reines, HD, 1992)
" Maximum serum-sodium concentrations correlated with sodium-bicarbonate dosage but not I."	1.26	Hyaline-membrane disease, alkaline buffer treatment, and cerebral intraventricular halphaemorrhage. ( Anderson, JM; Bain, AD; Brown, JK; Cockburn, F; Forfar, JO; Machin, GA; Turner, TL, 1976)
"Severe dehydration in infants is a common life threatening condition."	1.25	[Infusion treatment in severe dehydration (infantile toxicosis)]. ( Egli, F; Stalder, G; Wyss, P, 1975)
"Prophylaxis and treatment of cerebral edema with dexamethasone is of equal importance to primary emergency therapy and reanimation."	1.25	[Clinic and therapy of the so-called hyperosmolar syndrome in childhood (author's transl)]. ( Emmrich, P; Stechele, U, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (77.78)	18.7374
1990's	3 (6.67)	18.2507
2000's	3 (6.67)	29.6817
2010's	4 (8.89)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Goldwasser, P	1
Ayoub, I	1
Barth, RH	1
Bhosale, GP	1
Shah, VR	1
Das, SK	1
Afroze, F	1
Ahmed, T	1
Faruque, AS	1
Sarker, SA	1
Huq, S	1
Islam, MM	1
Shahrin, L	1
Matin, FB	1
Chisti, MJ	1
Ekpebegh, C	1
Longo-Mbenza, B	1
Coulthard, MG	1
Haycock, GB	1
BOEN, ST	1
Feldman, M	1
Soni, NJ	1
Dickson, B	1
John, AI	1
Fedeczko, D	1
Fernando, NP	1
Lacroix, J	1
Chicoine, L	1
Puczynski, MS	1
Cunningham, DG	1
Mortimer, JC	1
Narins, RG	1
Jones, ER	1
Stom, MC	1
Rudnick, MR	1
Bastl, CP	1
Yilmaz, K	1
Karaböcüoglu, M	1
Citak, A	1
Uzel, N	1
White, BC	1
Tintinalli, JE	1
Tobin, M	1
Mookerjee, BK	1
Anderson, JM	1
Bain, AD	1
Brown, JK	1
Cockburn, F	1
Forfar, JO	1
Machin, GA	1
Turner, TL	1
Webb, AK	1
Phillips, MJ	1
Hanson, GC	1
Huntington, RW	1
Weisberg, HF	1
Oh, W	1
Cockington, RA	1
Gold, H	1
Vonwiller, JB	1
Turbeville, DF	1
Bowen, FW	1
Killam, AP	1
Whang, R	2
Banister, A	1
Matin-Siddiqi, SA	1
Hatcher, GW	1
Egli, F	1
Wyss, P	1
Stalder, G	1
Malpuech, G	1
Godeneche, P	1
Meyer, M	1
Raynaud, EJ	1
Emmrich, P	1
Stechele, U	1
Kirschbaum, B	1
Galishoff, M	1
Reines, HD	1
Raya, A	1
Giner, P	1
Aranegui, P	1
Guerrero, F	1
Vazquez, G	1
Nose, H	1
Takamata, A	1
Mack, GW	1
Oda, Y	1
Okuno, T	1
Kang, DH	1
Morimoto, T	1
Fuchs, S	1
Listernick, R	1
Langberg, H	1
Hartmann, A	1
Ostensen, J	1
Mathisen, O	2
Kiil, F	1
Schindler, AM	1
Hiner, LB	1
Schistad, O	1
Strand, M	1
Copeland, JG	1
Channick, JM	1
Gittes, RF	1
Volpe, J	1
Simmons, MA	1
Adcock, EW	1
Bard, H	1
Battaglia, FC	1
Joly, JB	1
Bouhanna, A	1
Boigne, N	1
Huault, G	1
Kachaner, J	1
Saint-Martin, J	1
Solymoss, B	1
Classen, HG	1
Varga, S	1
Makoff, DL	1
da Silva, JA	1
Rosenbaum, BJ	1
Levy, SE	1
Maxwell, MH	1
Shuck, JM	1
Kempers, GR	1
Ahmed, I	1
Agusto-Odutola, TB	1
Landsberg, L	1
Gault, MH	1
Ferguson, EL	1
Sidhu, JS	1
Corbin, RP	1
Nitzan, M	1
Zelmanovsky, S	1
Tikva, P	1
Forbes, GB	1
McCoord, A	1
Brown, J	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia[NCT04744987]				122 participants (Actual)	Observational	2019-07-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Distinguishing between salt poisoning and hypernatraemic dehydration in children. BMJ (Clinical research ed.), 2003, Jan-18, Volume: 326, Issue:7381 Topics: Bicarbonates; Body Weight; Child; Dehydration; Diagnosis, Differential; Humans; Hypernatremia; Male;	2003
Diagnostic strategies in disorders of fluid, electrolyte and acid-base homeostasis. The American journal of medicine, 1982, Volume: 72, Issue:3 Topics: Acid-Base Imbalance; Acidosis; Alkalosis; Bicarbonates; Calcium Metabolism Disorders; Humans; Hyperk	1982
Disorder of fluid and electrolytes in newborn infants. Pediatric clinics of North America, 1976, Volume: 23, Issue:4 Topics: Bicarbonates; Dehydration; Female; Glomerular Filtration Rate; Humans; Hypernatremia; Hyponatremia;	1976

Article	Year
Pseudohypernatremia and pseudohyponatremia: a linear correction. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2015, Volume: 30, Issue:2 Topics: Albumins; Bicarbonates; Blood Proteins; Glucose; Humans; Hypernatremia; Hyponatremia; Retrospective	2015
Successful recovery from iatrogenic severe hypernatremia and severe metabolic acidosis resulting from accidental use of inappropriate bicarbonate concentrate for hemodialysis treatment. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2015, Volume: 26, Issue:1 Topics: Acidosis; Bicarbonates; Buffers; Dialysis Solutions; Humans; Hypernatremia; Male; Middle Aged; Renal	2015
Extreme hypernatremic dehydration due to potential sodium intoxication: consequences and management for an infant with diarrhea at an urban intensive care unit in Bangladesh: a case report. Journal of medical case reports, 2015, Jun-02, Volume: 9 Topics: Anticonvulsants; Bangladesh; Bicarbonates; Dehydration; Diarrhea, Infantile; Female; Fluid Therapy;	2015
Determinants of altered sensorium at presentation with diabetic ketoacidosis. Minerva endocrinologica, 2011, Volume: 36, Issue:4 Topics: Adult; Bicarbonates; Communicable Diseases; Consciousness Disorders; Diabetic Ketoacidosis; Emergenc	2011
[CLINICAL SIGNIFICANCE OF VARIATIONS IN THE ELECTROLYTE CONCENTRATION OF THE SERUM]. Nederlands tijdschrift voor geneeskunde, 1964, Feb-15, Volume: 108 Topics: Bicarbonates; Calcium; Calcium, Dietary; Carbon Dioxide; Chlorides; Electrolytes; Humans; Hypercalce	1964
Use of sodium concentration and anion gap to improve correlation between serum chloride and bicarbonate concentrations. Journal of clinical laboratory analysis, 2006, Volume: 20, Issue:4 Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Bicarbonates; Female; Humans; Hypernatremia; Hyponatremi	2006
Hypernatraemic dehydration in infants in Kuwait with special reference to therapy of associated metabolic acidosis. Annals of tropical paediatrics, 1984, Volume: 4, Issue:4 Topics: Acidosis; Bicarbonates; Dehydration; Female; Fluid Therapy; Glucose; Humans; Hypernatremia; Infant;	1984
[Metabolic alkalosis in a newborn infant caused by topical application of bicarbonate]. L'union medicale du Canada, 1982, Volume: 111, Issue:11 Topics: Administration, Topical; Alkalosis; Bicarbonates; Diaper Rash; Gastroenteritis; Humans; Hypernatremi	1982
Sodium intoxication caused by use of baking soda as a home remedy. Canadian Medical Association journal, 1983, Apr-01, Volume: 128, Issue:7 Topics: Bicarbonates; Child, Preschool; Female; Humans; Hypernatremia; Self Medication; Sodium; Sodium Bicar	1983
Evaluation of laboratory tests in dehydrated children with acute gastroenteritis. Journal of paediatrics and child health, 2002, Volume: 38, Issue:3 Topics: Acute Disease; Bicarbonates; Blood Chemical Analysis; Clinical Laboratory Techniques; Diarrhea, Infa	2002
Hemodialysis for phenformin associated lactic acidosis. Journal of dialysis, 1978, Volume: 2, Issue:3 Topics: Acid-Base Imbalance; Acidosis; Adult; Bicarbonates; Female; Humans; Hydrogen-Ion Concentration; Hype	1978
Hyaline-membrane disease, alkaline buffer treatment, and cerebral intraventricular halphaemorrhage. Lancet (London, England), 1976, Jan-17, Volume: 1, Issue:7951 Topics: Bicarbonates; Birth Weight; Blood Coagulation; Buffers; Carbon Dioxide; Cerebral Hemorrhage; Female;	1976
Iatrogenic nondiabetic hyperosmolar states. Journal of the Royal Society of Medicine, 1979, Volume: 72, Issue:8 Topics: Acid-Base Imbalance; Adult; Aged; Bicarbonates; Cerebral Hemorrhage; Citrates; Female; Glucose Solut	1979
Unusual form of child abuse. Journal of forensic sciences, 1977, Volume: 22, Issue:1 Topics: Bicarbonates; Child; Child Abuse; Homicide; Humans; Hypernatremia; Male; Sodium; Sodium Bicarbonate;	1977
Hypernatraemia in childhood. The Medical journal of Australia, 1977, Jun-25, Volume: 1, Issue:26 Topics: Bicarbonates; Child; Child, Preschool; Humans; Hypernatremia; Infant; Plasma Substitutes; Potassium;	1977
Intracranial hemorrhages in kittens: hypernatremia versus hypoxia. The Journal of pediatrics, 1976, Volume: 89, Issue:2 Topics: Animals; Animals, Newborn; Bicarbonates; Carbon Dioxide; Cats; Cerebral Hemorrhage; Hypernatremia; H	1976
'Bicarbonate overshot": an indication for acetazolamide therapy. Southern medical journal, 1975, Volume: 68, Issue:6 Topics: Acetazolamide; Alkalosis; Bicarbonates; Humans; Hypernatremia; Hypertonic Solutions; Male; Middle Ag	1975
Treatment of hypernatraemic dehydration in infancy. Archives of disease in childhood, 1975, Volume: 50, Issue:3 Topics: Bicarbonates; Body Weight; Dehydration; Gastroenteritis; Humans; Hyperglycemia; Hypernatremia; Hypoc	1975
[Infusion treatment in severe dehydration (infantile toxicosis)]. Infusionstherapie und klinische Ernahrung, 1975, Volume: 2, Issue:1 Topics: Alkalosis; Bicarbonates; Body Weight; Cerebrospinal Fluid Proteins; Child, Preschool; Dehydration; D	1975
[Renal papillary necrosis in an infant]. Archives francaises de pediatrie, 1975, Volume: 32, Issue:5 Topics: Acidosis; Bicarbonates; Dehydration; Diuresis; Gluconates; Glucose; Hematoma, Subdural; Humans; Hype	1975
[Clinic and therapy of the so-called hyperosmolar syndrome in childhood (author's transl)]. Medizinische Klinik, 1975, Sep-12, Volume: 70, Issue:37 Topics: Acidosis; Bicarbonates; Brain Edema; Child, Preschool; Chlorides; Dexamethasone; Dextrans; First Aid	1975
Lactic acidosis treated with continuous hemodiafiltration and regional citrate anticoagulation. Critical care medicine, 1992, Volume: 20, Issue:3 Topics: Acidosis, Lactic; Adult; Aged; Bicarbonates; Chlorides; Citrates; Citric Acid; Female; Hemofiltratio	1992
Fatal acute hypernatremia caused by massive intake of salt. Archives of internal medicine, 1992, Volume: 152, Issue:3 Topics: Acute Disease; Adult; Bicarbonates; Female; Humans; Hypernatremia; Sodium; Sodium Bicarbonate; Sodiu	1992
Water and electrolyte balance in the vascular space during graded exercise in humans. Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 70, Issue:6 Topics: Adult; Bicarbonates; Exercise; Humans; Hypernatremia; Lactates; Lactic Acid; Male; Osmolar Concentra	1991
Hypernatremia and metabolic alkalosis as a consequence of the therapeutic misuse of baking soda. Pediatric emergency care, 1987, Volume: 3, Issue:4 Topics: Alkalosis; Bicarbonates; Female; Fluid Therapy; Hospitalization; Humans; Hypernatremia; Infant; Sodi	1987
Hypernatremia inhibits NaHCO3 reabsorption and associated NaCl reabsorption in dogs. Kidney international, 1986, Volume: 29, Issue:4 Topics: Acetazolamide; Acid-Base Equilibrium; Animals; Bicarbonates; Carbon Dioxide; Dogs; Ethacrynic Acid;	1986
Hypernatremic metabolic alkalosis in a two-month-old infant. Hospital practice (Office ed.), 1988, May-30, Volume: 23, Issue:5A Topics: Administration, Oral; Alkalosis; Bicarbonates; Fluid Therapy; Humans; Hypernatremia; Infant; Male; M	1988
Role of osmosis in biliary NaCl secretion and bile formation. Scandinavian journal of gastroenterology, 1985, Volume: 20, Issue:8 Topics: Animals; Bicarbonates; Bile; Bile Acids and Salts; Hydrogen-Ion Concentration; Hypernatremia; Infusi	1985
Complications of a "Mayo enema". Treatment of resulting hypernatremia and alkalosis. California medicine, 1972, Volume: 116, Issue:5 Topics: Adult; Alkalosis; Bicarbonates; Enema; Humans; Hypernatremia; Male; Renal Dialysis; Sodium	1972
Editorial: Neonatal intracranial hemorrhage--iatrogenic etiology? The New England journal of medicine, 1974, Jul-04, Volume: 291, Issue:1 Topics: Bicarbonates; Cerebral Hemorrhage; Cerebral Ventricles; Humans; Hypernatremia; Iatrogenic Disease; I	1974
Hypernatremia and intracranial hemorrhage in neonates. The New England journal of medicine, 1974, Jul-04, Volume: 291, Issue:1 Topics: Bicarbonates; Cerebral Hemorrhage; Colorado; Humans; Hypernatremia; Infant, Newborn; Infant, Newborn	1974
[Results of 62 peritoneal dialyses in the newborn, infants and children. Application in pediatric emergencies]. Archives francaises de pediatrie, 1970, Volume: 27, Issue:3 Topics: Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Anuria; Bicarbonates; Blood Glucose; Blood Pro	1970
The role of electrolyte disturbances and extracellular alkalosis in metabolic cardiac necrosis and the preventive effect of amiloride. The American journal of cardiology, 1970, Volume: 26, Issue:1 Topics: Acid-Base Equilibrium; Alkalosis; Animals; Bicarbonates; Carbon Dioxide; Chlorides; Electrolytes; Fe	1970
Hypertonic expansion: acid-base and electrolyte changes. The American journal of physiology, 1970, Volume: 218, Issue:4 Topics: Acidosis; Animals; Bicarbonates; Carbon Isotopes; Chlorides; Dogs; Extracellular Space; Hydrogen-Ion	1970
A hazard of peritoneal dialysis in burned patients: hyperosmolar coma. The Journal of trauma, 1970, Volume: 10, Issue:4 Topics: Alkalosis; Bicarbonates; Burns, Chemical; Coma; Edema; Humans; Hyperglycemia; Hypernatremia; Infant;	1970
Hypernatraemia in diarrhoeal infants in Lagos. Archives of disease in childhood, 1970, Volume: 45, Issue:239 Topics: Bicarbonates; Blood Urea Nitrogen; Cerebrospinal Fluid Proteins; Child, Preschool; Chlorides; Dehydr	1970
Hypernatremia complicating partial urinary-tract obstruction. The New England journal of medicine, 1970, Oct-01, Volume: 283, Issue:14 Topics: Aged; Bicarbonates; Blood Urea Nitrogen; Chlorides; Dehydration; Diabetes Insipidus; Humans; Hydrone	1970
Fluid and electrolyte complications of peritoneal dialysis. Choice of dialysis solutions. Annals of internal medicine, 1971, Volume: 75, Issue:2 Topics: Acute Kidney Injury; Adult; Alkalosis; Bicarbonates; Blood; Blood Glucose; Blood Pressure; Blood Ure	1971
Glucose intolerance in hypernatremic rats. Diabetes, 1968, Volume: 17, Issue:9 Topics: Animals; Bicarbonates; Blood Glucose; Carbohydrate Metabolism; Chlorides; Glucose; Hypernatremia; Ma	1968
Bone sodium as a function of serum sodium in rats. The American journal of physiology, 1965, Volume: 209, Issue:4 Topics: Acidosis; Alkalosis; Ammonium Chloride; Animals; Bicarbonates; Blood; Blood Gas Analysis; Bone and B	1965
Iatrogenic alkalosis in childhood. The Medical journal of Australia, 1965, Oct-23, Volume: 2, Issue:17 Topics: Alkalosis; Bicarbonates; Child, Preschool; Female; Gastroenteritis; Humans; Hypernatremia; Iatrogeni	1965

hydrogen carbonate and Hypernatremia

Research Excerpts

Research

Studies (45)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies