hydrogen carbonate has been researched along with Hemangiosarcoma in 1 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Hemangiosarcoma: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In carcinogenicity studies, pregabalin increased hemangiosarcoma incidence in mice but not in rats." | 7.78 | Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats. ( Albassam, M; Anderson, T; Bailie, M; Criswell, KA; Duddy, S; Foote, S; Olsen, E; Pegg, D; Wojcinski, Z, 2012) |
| "In carcinogenicity studies, pregabalin increased hemangiosarcoma incidence in mice but not in rats." | 3.78 | Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats. ( Albassam, M; Anderson, T; Bailie, M; Criswell, KA; Duddy, S; Foote, S; Olsen, E; Pegg, D; Wojcinski, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Criswell, KA | 1 |
| Wojcinski, Z | 1 |
| Pegg, D | 1 |
| Albassam, M | 1 |
| Duddy, S | 1 |
| Olsen, E | 1 |
| Bailie, M | 1 |
| Foote, S | 1 |
| Anderson, T | 1 |
1 other study available for hydrogen carbonate and Hemangiosarcoma
| Article | Year |
|---|---|
Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats.
Topics: Animals; Bicarbonates; Blood Gas Analysis; Erythropoiesis; Female; Fibroblast Growth Factor 2; gamma | 2012 |