hydrogen carbonate has been researched along with Exocrine Pancreatic Insufficiency in 24 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Exocrine Pancreatic Insufficiency: A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 9.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 5.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "A quantitative correlation between computer-tomographic (CT) findings and exocrine pancreatic function following secretin-ceruletide stimulation was performed in 48 patients with chronic pancreatitis; thereby a significant correlation between the degree of morphological changes in CT and the stage of functional impairment was found (r = 0,7841, p less than 0,001)." | 3.66 | [Ct-morphology and exocrine function in chronic pancreatitis]. ( Büchler, M; Ditschuneit, H; Maier, W; Malfertheiner, P; Walliser, A, 1983) |
| "The effect of the addition of sodium bicarbonate, aluminum hydroxide, magnesium hydroxide, calcium carbonate, or cimetidine to supplemental pancreatic enzyme therapy was investigated in patients with severe exocrine pancreatic insufficiency." | 3.66 | Pancreatic enzyme replacement: the effect of antacids or cimetidine. ( Graham, DY, 1982) |
| "Cystic fibrosis is a monogenic disease considered to affect at least 100 000 people worldwide." | 2.72 | Cystic fibrosis. ( Davies, JC; Haq, IJ; Polineni, D; Shteinberg, M, 2021) |
| "Among the 36 patients with alcoholic pancreatitis, most had impaired pancreatic function at both duodenal intubation (8/8, 100%) and at AACT (22/28, 78." | 1.32 | Exocrine pancreatic function after alcoholic or biliary acute pancreatitis. ( Gullo, L; Migliori, M; Pezzilli, R; Tomassetti, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (45.83) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Shteinberg, M | 1 |
| Haq, IJ | 1 |
| Polineni, D | 1 |
| Davies, JC | 1 |
| Engjom, T | 2 |
| Erchinger, F | 2 |
| Tjora, E | 2 |
| Lærum, BN | 2 |
| Georg, D | 1 |
| Gilja, OH | 2 |
| Aksnes, L | 1 |
| Dimcevski, G | 1 |
| Domínguez Muñoz, JE | 1 |
| Zhong, N | 1 |
| Saenger, AK | 1 |
| Topazian, M | 1 |
| Gleeson, FC | 1 |
| Chari, ST | 1 |
| Clain, JE | 1 |
| Levy, MJ | 1 |
| Rajan, E | 1 |
| Enders, FT | 1 |
| Pelley, JR | 1 |
| Gordon, SR | 1 |
| Gardner, TB | 1 |
| Migliori, M | 1 |
| Pezzilli, R | 1 |
| Tomassetti, P | 1 |
| Gullo, L | 2 |
| Talamini, G | 1 |
| Kalnins, D | 1 |
| Ellis, L | 1 |
| Corey, M | 1 |
| Pencharz, PB | 1 |
| Stewart, C | 1 |
| Tullis, E | 1 |
| Durie, PR | 2 |
| Malfertheiner, P | 1 |
| Maier, W | 1 |
| Walliser, A | 1 |
| Büchler, M | 1 |
| Ditschuneit, H | 1 |
| Graham, DY | 2 |
| Adelson, JW | 1 |
| Pidgeon, G | 1 |
| Strombeck, DR | 1 |
| Bell, L | 1 |
| Linton, W | 1 |
| Corey, ML | 1 |
| Forstner, GG | 1 |
| Bozkurt, T | 1 |
| Braun, U | 1 |
| Leferink, S | 1 |
| Gilly, G | 1 |
| Lux, G | 1 |
| Bovo, P | 1 |
| Cataudella, G | 1 |
| Di Francesco, V | 1 |
| Vaona, B | 1 |
| Filippini, M | 1 |
| Marcori, M | 1 |
| Montesi, G | 1 |
| Rigo, L | 1 |
| Frulloni, L | 1 |
| Brunori, MP | 1 |
| D'Ambrosi, A | 1 |
| Verzola, A | 1 |
| Gennaro, P | 1 |
| Gatto, S | 1 |
| Catellani, M | 1 |
| La Corte, R | 1 |
| Borgo, G | 1 |
| Mastella, G | 1 |
| Gasparini, P | 1 |
| Zorzanello, A | 1 |
| Doro, R | 1 |
| Pignatti, PF | 1 |
| Chen, WL | 1 |
| Morishita, R | 1 |
| Eguchi, T | 1 |
| Kawai, T | 1 |
| Uchino, H | 1 |
| Gerber, B | 1 |
| Gerber, S | 1 |
| Arendt, R | 1 |
| Lankisch, PG | 1 |
| Otto, J | 1 |
| Santini, B | 1 |
| Dell'Olio, D | 1 |
| Robazza, PV | 1 |
| Fantino, N | 1 |
| Ansaldi, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development a Core Set for Adults With Cystic Fibrosis Based on the International Classification of Functioning, Disability, and Health (ICF)[NCT06128499] | 30 participants (Anticipated) | Observational | 2023-12-20 | Not yet recruiting | |||
| Magnetic Resonance Cholangiopancreatography (MRCP): A Reliable, Non Invasive Method for Staging Chronic Pancreatitis From Minimal Change Disease to the Advanced Stages in Pediatrics[NCT02869893] | 57 participants (Actual) | Interventional | 2016-08-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Healthy controls underwent 3D MRE on a 1.5T scanner. Regions of interest for measurement of pancreatic stiffness were drawn by two blinded readers and statistical analysis were performed for comparisons between the 2 groups. (NCT02869893)
Timeframe: Single time point, pre-secretin
| Intervention | kPa (Mean) |
|---|---|
| Healthy Participants | 1.7 |
"Participants underwent MR imaging prior to and following secretin administration. Pre-secretin imaging lasts approximately 20 minutes. Post-secretin images were acquired at 1 minute, 5 minutes and 15 minutes following completion of secretin injection. Pre-secretin enteric fluid volumes were subtracted from post-secretin enteric fluid volumes for each participant to determine volume secreted in response to secretin administration at each time point.~A commercially available software package determines the area of fluid signal on the MR images. The fluid signal from the pre-secretin images is then subtracted from the each post-secretin image (1, 5 and 15 minutes images) to determine the amount of fluid produced by the introduction of secretin." (NCT02869893)
Timeframe: 35 minutes (20 min pre-secretin, 15 minutes post-secretin)
| Intervention | mL (Median) |
|---|---|
| Healthy Participants | 79 |
Pancreatic parenchymal volume by manual segmentation (tracing) of pancreas contours on magnetic resonance imaging (MRI) (NCT02869893)
Timeframe: Single time point, pre-secretin
| Intervention | mL (Mean) |
|---|---|
| Healthy Participants | 46 |
3 reviews available for hydrogen carbonate and Exocrine Pancreatic Insufficiency
| Article | Year |
|---|---|
Cystic fibrosis.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disea | 2021 |
[Latest advances in chronic pancreatitis].
Topics: Autoimmune Diseases; Bicarbonates; Early Diagnosis; Elasticity Imaging Techniques; Endoscopic Ultras | 2015 |
Pathophysiology of the pancreas in cystic fibrosis.
Topics: Animals; Bicarbonates; Biological Transport; Chlorides; Cystic Fibrosis; Exocrine Pancreatic Insuffi | 1984 |
3 trials available for hydrogen carbonate and Exocrine Pancreatic Insufficiency
| Article | Year |
|---|---|
Enteric-coated pancreatic enzyme with bicarbonate is equal to standard enteric-coated enzyme in treating malabsorption in cystic fibrosis.
Topics: Adolescent; Adult; Bicarbonates; Child; Cross-Over Studies; Cystic Fibrosis; Double-Blind Method; Ex | 2006 |
Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.
Topics: Adolescent; Bicarbonates; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Dietary Fats; Drug The | 1980 |
Maximal effective dose of cerulein in the secretin-cerulein test.
Topics: Adult; Bicarbonates; Ceruletide; Chronic Disease; Chymotrypsin; Clinical Trials as Topic; Exocrine P | 1988 |
18 other studies available for hydrogen carbonate and Exocrine Pancreatic Insufficiency
| Article | Year |
|---|---|
Diagnostic accuracy of secretin-stimulated ultrasonography of the pancreas assessing exocrine pancreatic failure in cystic fibrosis and chronic pancreatitis.
Topics: Adolescent; Adult; Aged; Bicarbonates; Case-Control Studies; Cystic Fibrosis; Duodenum; Exocrine Pan | 2015 |
Diagnostic Accuracy of a Short Endoscopic Secretin Test in Patients With Cystic Fibrosis.
Topics: Adolescent; Adult; Aged; Bicarbonates; Cystic Fibrosis; Duodenum; Endoscopy; Exocrine Pancreatic Ins | 2015 |
An automated analyzer provides clinically concordant results to manual back titration for quantitation of bicarbonate in pancreatic juice.
Topics: Adult; Autoanalysis; Bicarbonates; Exocrine Pancreatic Insufficiency; Female; Humans; Male; Middle A | 2011 |
Abnormal duodenal [HCO3-] following secretin stimulation develops sooner than endocrine insufficiency in minimal change chronic pancreatitis.
Topics: Adult; Bicarbonates; Chi-Square Distribution; Disease Progression; Duodenum; Endosonography; Exocrin | 2012 |
Exocrine pancreatic function after alcoholic or biliary acute pancreatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Amino Acids; Bicarbonates; Ceruletide; Cholelithiasis; Chymo | 2004 |
Duodenal acidity may increase the risk of pancreatic cancer in the course of chronic pancreatitis: an etiopathogenetic hypothesis.
Topics: Alcohol Drinking; Bicarbonates; Duodenum; Exocrine Pancreatic Insufficiency; Gastric Acid; Humans; H | 2005 |
[Ct-morphology and exocrine function in chronic pancreatitis].
Topics: Adult; Aged; Amylases; Bicarbonates; Ceruletide; Chronic Disease; Chymotrypsin; Exocrine Pancreatic | 1983 |
Pancreatic enzyme replacement: the effect of antacids or cimetidine.
Topics: Adult; Aluminum Hydroxide; Antacids; Bicarbonates; Calcium Carbonate; Celiac Disease; Cimetidine; Ex | 1982 |
Ins and outs of pancreatic enzymes and adjuvant therapies.
Topics: Bicarbonates; Celiac Disease; Enzyme Therapy; Exocrine Pancreatic Insufficiency; Humans; Lipase; Pan | 1984 |
Evaluation of treatment for pancreatic exocrine insufficiency in dogs with ligated pancreatic ducts.
Topics: Animals; Bicarbonates; Bile Acids and Salts; Cimetidine; Dog Diseases; Dogs; Exocrine Pancreatic Ins | 1982 |
Comparison of pancreatic morphology and exocrine functional impairment in patients with chronic pancreatitis.
Topics: Adult; Aged; Amylases; Bicarbonates; Chronic Disease; Exocrine Pancreatic Insufficiency; Female; Hum | 1994 |
Intraluminal gastric pH in chronic pancreatitis.
Topics: Bicarbonates; Chronic Disease; Circadian Rhythm; Digestion; Exocrine Pancreatic Insufficiency; Femal | 1995 |
[Functional reserve of the exocrine pancreas in Sjögren's syndrome].
Topics: Adult; Aged; Arthritis, Rheumatoid; Bicarbonates; Ceruletide; Exocrine Pancreatic Insufficiency; Fem | 1997 |
Pancreatic function and gene deletion F508 in cystic fibrosis.
Topics: Adolescent; Adult; Bicarbonates; Child; Child, Preschool; Chromosome Deletion; Chromosomes, Human, P | 1990 |
The absorption of free vitamin B12 and R protein-bound vitamin B12 in the diagnosis of pancreatic exocrine insufficiency in rats.
Topics: Animals; Bicarbonates; Bile Ducts; Exocrine Pancreatic Insufficiency; Intestinal Absorption; Ligatio | 1987 |
[Interdigestive and postprandial duodenal pH in healthy probands, in patients with ulcer and in chronic pancreatitis].
Topics: Acid-Base Equilibrium; Bicarbonates; Chronic Disease; Duodenal Ulcer; Duodenum; Eating; Exocrine Pan | 1987 |
Salivary isoamylase in duodenal aspirates.
Topics: Adolescent; Adult; Aged; Bicarbonates; Cholecystokinin; Duodenum; Exocrine Pancreatic Insufficiency; | 1986 |
[Evaluation of the function of the exocrine pancreas in childhood by stimulation with ceruletide and secretin].
Topics: Bicarbonates; Ceruletide; Child; Child, Preschool; Cystic Fibrosis; Exocrine Pancreatic Insufficienc | 1985 |