hydrogen carbonate and Embryopathies studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Research Excerpts

Excerpt	Relevance	Reference
"To investigate whether fetal acidosis increases the placental transfer of lidocaine, resulting in higher fetal blood levels of the drug, lidocaine was infused intravenously into ten pregnant ewes to maintain plasma levels of 2-4 microgram/ml."	7.66	Placental transfer of lidocaine: effects of fetal acidosis. ( Biehl, D; Callender, K; Levinson, G; Shnider, SM, 1978)
"Our purpose was to determine whether the fetal acidosis and hypoxia previously demonstrated in animal models with maternal nifedipine infusion is the result of a decrease in uteroplacental or fetoplacental blood flow and whether this effect is exacerbated by a higher drug concentration and duration of infusion."	3.69	Effect of nifedipine on fetal and maternal hemodynamics and blood gases in the pregnant ewe. ( Barnard, JM; Blea, CW; Hendricks, SK; Magness, RR; Phernetton, TM, 1997)
"To investigate whether fetal acidosis increases the placental transfer of lidocaine, resulting in higher fetal blood levels of the drug, lidocaine was infused intravenously into ten pregnant ewes to maintain plasma levels of 2-4 microgram/ml."	3.66	Placental transfer of lidocaine: effects of fetal acidosis. ( Biehl, D; Callender, K; Levinson, G; Shnider, SM, 1978)
"Severe preeclampsia affects placental function and causes fetal compromise."	1.28	The value of cordocentesis in management of patients with severe preeclampsia. ( Chiu, TH; Hsieh, TT; Kuo, DM; Lo, LM, 1991)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (87.80)	18.7374
1990's	4 (9.76)	18.2507
2000's	1 (2.44)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
ROOTH, G	1
HELLEGERS, AE	1
TUNSTALL, ME	1
Wiberg, N	1
Källén, K	1
Olofsson, P	1
Blechner, JN	2
Stenger, VG	1
Eitzman, DV	1
Prystowsky, H	1
Sabik, JF	1
Heinemann, MK	1
Assad, RS	1
Hanley, FL	1
Blea, CW	1
Barnard, JM	1
Magness, RR	1
Phernetton, TM	1
Hendricks, SK	1
Andres, RL	1
Saade, G	1
Gilstrap, LC	1
Wilkins, I	1
Witlin, A	1
Zlatnik, F	1
Hankins, GV	1
Biehl, D	1
Shnider, SM	1
Levinson, G	1
Callender, K	1
Kastendieck, E	1
Künzel, W	1
Caspi, E	1
Ron-El, R	1
Modai, D	1
Boog, G	1
Marzolf, G	1
Gandar, R	1
De Grandi, P	1
Hsieh, TT	1
Kuo, DM	1
Lo, LM	1
Chiu, TH	1
Symonds, EM	5
Barrie, H	1
Seeds, AE	1
Escarcena, L	1
Chernukha, EA	1
Fefilov, AI	1
Johnson, GH	1
Brinkman, CR	1
Assali, NS	1
Stulc, JJ	1
Rietveld, WJ	1
Soeteman, DW	1
Versprille, A	1
Dellenbach, P	1
Marianowski, L	2
Hamilton, LA	2
Behrman, RE	2
Folger, GM	1
Singh, HA	1
Williams, SS	1
Cellier, KM	1
Cohen, H	1
Brown, WU	1
DeVore, J	1
James, LS	1
Martin, K	1
Rathgen, GH	1
Schwethelm, R	1
Beck, L	1
Gazárek, F	1
Skácel, K	1
Podivínský, R	1
Lhoták, J	1
Sklenárová, L	1
Lubusský, D	1
Krikal, Z	1
Horská, S	1
Stembera, ZK	1
Vondrácek, J	1
Savel'eva, GM	2
Clayton, SG	1
MacRae, DJ	1
Kittrich, M	1
Krause, W	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia[NCT00482573]			Phase 1	31 participants (Actual)	Interventional	2004-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
PLACENTAL EXCHANGE OF OXYGEN AND CARBON DIOXIDE. Modern trends in human reproductive physiology, 1963, Volume: 15 Topics: Bicarbonates; Blood Gas Analysis; Carbon Dioxide; Female; Fetal Diseases; Fetal Hemoglobin; Humans;	1963
NEONATAL RESUSCITATION. British journal of anaesthesia, 1964, Volume: 36 Topics: Asphyxia Neonatorum; Bicarbonates; Blood Transfusion; Fetal Diseases; Heart Massage; Humans; Hyperba	1964
Prevention and correction of fetal acidosis and hypoxia. Clinical obstetrics and gynecology, 1974, Volume: 17, Issue:3 Topics: Acidosis; Amniotic Fluid; Bicarbonates; Birth Weight; Carbon Dioxide; Estriol; Female; Fetal Disease	1974
[Determination of fetal maturity by amniotic fluid (literature survey)]. Voprosy okhrany materinstva i detstva, 1972, Volume: 17, Issue:6 Topics: Alkaline Phosphatase; Amine Oxidase (Copper-Containing); Amniotic Fluid; Bicarbonates; Bilirubin; Ca	1972

Article	Year
EARLY DETECTION AND PREVENTION OF FOETAL ACIDOSIS. Lancet (London, England), 1964, Feb-08, Volume: 1, Issue:7328 Topics: Acidosis; Asphyxia Neonatorum; Bicarbonates; Blood Chemical Analysis; Blood Gas Analysis; Female; Fe	1964
Physiological development of a mixed metabolic and respiratory umbilical cord blood acidemia with advancing gestational age. Early human development, 2006, Volume: 82, Issue:9 Topics: Acidosis; Age Factors; Bicarbonates; Birth Weight; Blood Gas Analysis; Carbon Dioxide; Cohort Studie	2006
Effects of maternal metabolic acidosis on the human fetus and newborn infant. American journal of obstetrics and gynecology, 1967, Sep-01, Volume: 99, Issue:1 Topics: Acid-Base Equilibrium; Acidosis; Adult; Ammonium Chloride; Bicarbonates; Blood Gas Analysis; Carbon	1967
High-dose steroids prevent placental dysfunction after fetal cardiac bypass. The Journal of thoracic and cardiovascular surgery, 1994, Volume: 107, Issue:1 Topics: Animals; Bicarbonates; Blood Flow Velocity; Carbon Dioxide; Cardiac Output; Cardiopulmonary Bypass;	1994
Effect of nifedipine on fetal and maternal hemodynamics and blood gases in the pregnant ewe. American journal of obstetrics and gynecology, 1997, Volume: 176, Issue:4 Topics: Acidosis; Animals; Bicarbonates; Female; Fetal Blood; Fetal Diseases; Fetus; Half-Life; Hemodynamics	1997
Association between umbilical blood gas parameters and neonatal morbidity and death in neonates with pathologic fetal acidemia. American journal of obstetrics and gynecology, 1999, Volume: 181, Issue:4 Topics: Acidosis; Adolescent; Adult; Apgar Score; Bicarbonates; Carbon Dioxide; Cardiopulmonary Resuscitatio	1999
Placental transfer of lidocaine: effects of fetal acidosis. Anesthesiology, 1978, Volume: 48, Issue:6 Topics: Acidosis; Animals; Bicarbonates; Blood Pressure; Female; Fetal Diseases; Heart Rate; Hydrogen-Ion Co	1978
[The effect of placental transfer of bicarbonate on fetal metabolic acidosis. Experimental results and clinical aspects for the diagnosis and treatment of fetal acidosis (author's transl)]. Zeitschrift fur Geburtshilfe und Perinatologie, 1979, Volume: 183, Issue:1 Topics: Acidosis; Bicarbonates; Female; Fetal Diseases; Fetal Hypoxia; Humans; Hydrogen-Ion Concentration; I	1979
Controlled intravenous bicarbonate and fetal-maternal acid-base balance. I. The primipara. Obstetrics and gynecology, 1979, Volume: 54, Issue:5 Topics: Acid-Base Equilibrium; Acidosis; Adult; Apgar Score; Bicarbonates; Carbon Dioxide; Female; Fetal Blo	1979
[Intra-uterine resuscitation]. Gynakologische Rundschau, 1976, Volume: 16 Suppl 1 Topics: Bicarbonates; Female; Fetal Diseases; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; R	1976
The value of cordocentesis in management of patients with severe preeclampsia. Asia-Oceania journal of obstetrics and gynaecology, 1991, Volume: 17, Issue:1 Topics: Acidosis; Bicarbonates; Carbon Dioxide; Female; Fetal Blood; Fetal Diseases; Humans; Hydrogen-Ion Co	1991
Fetal cardiac arrhythmias and fetal acid-base status. The Australian & New Zealand journal of obstetrics & gynaecology, 1972, Volume: 12, Issue:3 Topics: Acidosis; Adult; Arrhythmias, Cardiac; Atrial Flutter; Bicarbonates; Blood; Carbon Dioxide; Cardiac	1972
Neonatal resuscitation. Acta anaesthesiologica Scandinavica. Supplementum, 1966, Volume: 25 Topics: Acidosis; Asphyxia Neonatorum; Bicarbonates; Blood Specimen Collection; Central Nervous System Stimu	1966
Response of the hypoxic fetal and neonatal lamb to administration of base solution. American journal of obstetrics and gynecology, 1972, Dec-01, Volume: 114, Issue:7 Topics: Animals; Animals, Newborn; Bicarbonates; Blood Pressure; Carbon Dioxide; Carotid Arteries; Ductus Ar	1972
The transplacental potential difference in guinea-pigs. Biology of the neonate, 1972, Volume: 21, Issue:1 Topics: Animals; Bicarbonates; Blood Pressure; Carbon Dioxide; Electrocardiography; Female; Fetal Diseases;	1972
[Emergency metabolic resuscitation of newborn infants in the delivery room. A simplified method]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1972, Volume: 1, Issue:6 Topics: Acidosis; Bicarbonates; Female; Fetal Diseases; Glucose; Humans; Infant, Newborn; Injections, Intrav	1972
[Treatment of fetal hypoxia based on gas and acid-base patterns in the amniotic fluid]. Ginekologia polska, 1974, Volume: 45, Issue:2 Topics: Acid-Base Equilibrium; Amniotic Fluid; Asphyxia Neonatorum; Bicarbonates; Female; Fetal Diseases; Ge	1974
Intra-amniotic infusion of bicarbonate in the treatment of human fetal acidosis. The Proceedings of the Institute of Medicine of Chicago, 1972, Volume: 29, Issue:2 Topics: Acidosis; Amnion; Bicarbonates; Female; Fetal Diseases; Humans; Infant, Newborn; Methods; Pregnancy	1972
Intra-amniotic infusion of bicarbonate in the treatment of human fetal acidosis. American journal of obstetrics and gynecology, 1972, Mar-15, Volume: 112, Issue:6 Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Adult; Amniotic Fluid; Anesthesia, Spinal; Apgar Score	1972
Vectorcardiography and acid-base balance in the human fetus. The Journal of obstetrics and gynaecology of the British Commonwealth, 1972, Volume: 79, Issue:5 Topics: Acid-Base Equilibrium; Acidosis; Apgar Score; Bicarbonates; Blood; Electrocardiography; Female; Feta	1972
Acidemia of cardiogenic origin in young infants with cyanotic congenital heart abnormalities. Pathogenesis, diagnosis and treatment, with particular emphasis on neonatal acid-base disturbance. Clinical pediatrics, 1972, Volume: 11, Issue:10 Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Cardiac Catheterization; Female; Fetal Diseases; Hear	1972
Red-cell potassium in chronic fetal asphyxia. The Journal of obstetrics and gynaecology of the British Commonwealth, 1972, Volume: 79, Issue:10 Topics: Acid-Base Equilibrium; Acidosis; Apgar Score; Asphyxia; Bicarbonates; Blood Gas Analysis; Carbon Dio	1972
Maternal and fetal influences on the acid-base balance of human amniotic fluid. Obstetrics and gynecology, 1971, Volume: 37, Issue:5 Topics: Acid-Base Equilibrium; Air; Amniotic Fluid; Apgar Score; Asphyxia; Bicarbonates; Buffers; Carbon Dio	1971
Configuration of the fetal electrocardiogram in relation to fetal acid-base balance and plasma electrolytes. The Journal of obstetrics and gynaecology of the British Commonwealth, 1971, Volume: 78, Issue:11 Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Blood; Computers; Electrocardiography; Female; Fetal	1971
Simultaneous electrophysical and biochemical monitoring of the fetus in labor. Southern medical journal, 1971, Volume: 64, Issue:11 Topics: Apgar Score; Bicarbonates; Cesarean Section; Electrocardiography; Female; Fetal Diseases; Fetal Hear	1971
[Blood level of mepivacaine (scandicaine) following paracervical block]. Geburtshilfe und Frauenheilkunde, 1969, Volume: 29, Issue:8 Topics: Anesthesia, Obstetrical; Autonomic Nerve Block; Bicarbonates; Blood; Bradycardia; Carbon Dioxide; Fe	1969
[Possibilities to affect the acid-base equilibrium in the parturient and the fetus]. Ceskoslovenska gynekologie, 1969, Volume: 34, Issue:9 Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Female; Fetal Diseases; Glucose; Humans; Infant, Newb	1969
The effect of ATP on the fetus in danger during labour. The Journal of obstetrics and gynaecology of the British Commonwealth, 1970, Volume: 77, Issue:11 Topics: Adenosine Triphosphate; Bicarbonates; Blood Glucose; Carbon Dioxide; Delivery, Obstetric; Female; Fe	1970
Fetal acid-base homeostasis. Clinical obstetrics and gynecology, 1970, Volume: 13, Issue:3 Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Alkalosis; Ammonium Chloride; Animals; Bicarbonates; C	1970
The usefulness of determination of acid-base balance parameters in the amniotic fluid. Polish medical journal, 1971, Volume: 10, Issue:1 Topics: Acid-Base Equilibrium; Amniotic Fluid; Bicarbonates; Carbon Dioxide; Female; Fetal Diseases; Fetal H	1971
[Administration of alkaline solutions to the mother with the aim of decreasing pathological metabolic acidosis in the blood of the fetus]. Akusherstvo i ginekologiia, 1967, Volume: 43, Issue:11 Topics: Acidosis; Bicarbonates; Female; Fetal Diseases; Humans; Maternal-Fetal Exchange; Pregnancy; Sodium	1967
Theoretical background to foetal acid-base balance. Proceedings of the Royal Society of Medicine, 1968, Volume: 61, Issue:5 Topics: Acid-Base Equilibrium; Bicarbonates; Blood Gas Analysis; Female; Fetal Diseases; Humans; Maternal-Fe	1968
Maternal influence on foetal acid-base balance. Proceedings of the Royal Society of Medicine, 1968, Volume: 61, Issue:5 Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Bicarbonates; Carbon Dioxide; Female; Fetal Diseases; Ho	1968
Changes in the acid-base balance of amniotic fluid during labour. The Journal of obstetrics and gynaecology of the British Commonwealth, 1968, Volume: 75, Issue:11 Topics: Acid-Base Equilibrium; Acidosis; Amniotic Fluid; Bicarbonates; Carbon Dioxide; Catheterization; Deli	1968
[Diagnosis of fetal diseases and amniotic fluid gas analysis]. Medizinische Klinik, 1969, Aug-01, Volume: 64, Issue:31 Topics: Amniotic Fluid; Bicarbonates; Carbon Dioxide; Erythroblastosis, Fetal; Female; Fetal Death; Fetal Di	1969
[The use of alkaline solutions in the treatment of asphyxia of the fetus and the newborn]. Akusherstvo i ginekologiia, 1969, Volume: 45, Issue:5 Topics: Alkalies; Asphyxia Neonatorum; Bicarbonates; Female; Fetal Diseases; Humans; Hydrogen-Ion Concentrat	1969

hydrogen carbonate and Embryopathies

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