hydrogen carbonate has been researched along with Disease Models, Animal in 176 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "St Thomas cardioplegia solution supplemented with emulsified isoflurane enhanced its cardioprotection in an isolated heart ischemia reperfusion injury model in rats." | 7.76 | Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats. ( Huang, H; Li, T; Liu, J; Liu, S; Yanfang, C; Zhang, W, 2010) |
| "Tenidap is a novel antirheumatic agent that causes a mild, reversible proteinuria in human clinical trials." | 7.69 | Model development and analysis of tenidap-induced proteinuria in the rat. ( Aleo, MD; Giebisch, G; Lopez-Anaya, A; Sanders, MJ; Walsh, AH; Wang, T, 1996) |
| "Two experimental studies were carried out upon dogs to clarify the efficacy of peritoneal povidone-iodine lavage in peritonitis." | 7.66 | Peritoneal lavage with povidone-iodine solution in experimentally induced peritonitis. ( Lores, ME; Ortíz, JR; Rosselló, PJ, 1981) |
| "Ouabain-induced tachyarrhythmias in cats can be abolished by bolus injection of NaHCO3 solution." | 7.65 | Antiarrhythmic effect of hypertonic sodium bicarbonate and sodium chloride in ouabain-induced arrhythmias. ( Aryanpur, I; Paydar, M; Reyhani, F; Shakibi, JG; Siassi, B, 1976) |
| "We used myocytes from Wistar, SHR, losartan-treated SHR (Los-SHR), and Angiotensin II (Ang II)-induced cardiac hypertrophy." | 3.80 | Reduced sarcolemmal expression and function of the NBCe1 isoform of the Na⁺-HCO₃⁻ cotransporter in hypertrophied cardiomyocytes of spontaneously hypertensive rats: role of the renin-angiotensin system. ( Aiello, EA; Caldiz, CI; Ciancio, MC; De Giusti, VC; Orlowski, A, 2014) |
| " We investigated the effect of the LXRα agonist, T0901317, on lung inflammation in a rodent model of hemorrhagic shock." | 3.77 | Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway. ( Denenberg, A; Hake, PW; Lentsch, A; O'Connor, M; Piraino, G; Solan, PD; Zingarelli, B, 2011) |
| "We have identified a novel homozygous nonsense mutation (W516X) in the kidney-type electrogenic sodium bicarbonate cotransporter 1 (NBC1) in a patient with isolated proximal renal tubular acidosis (pRTA)." | 3.77 | Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis. ( Fujita, T; Horita, S; Lin, SH; Lin, SW; Lo, YF; Seki, G; Tsai, JD; Usui, T; Yamada, H; Yamazaki, O; Yang, SS; Yu, IS, 2011) |
| "St Thomas cardioplegia solution supplemented with emulsified isoflurane enhanced its cardioprotection in an isolated heart ischemia reperfusion injury model in rats." | 3.76 | Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats. ( Huang, H; Li, T; Liu, J; Liu, S; Yanfang, C; Zhang, W, 2010) |
| " We have conducted studies to determine whether the protection afforded by the administration of sodium bicarbonate is sustained and prevents development of uremia during chronic administration and whether the effects of the administration of ammonium chloride and sodium bicarbonate are also observed in a different model of polycystic kidney disease, the CD1-pcy/pcy mouse." | 3.71 | Long-term ammonium chloride or sodium bicarbonate treatment in two models of polycystic kidney disease. ( Branden, MG; Cowley, BD; Gattone, VH; Torres, VE; Yoshida, I, 2001) |
| "Tenidap is a novel antirheumatic agent that causes a mild, reversible proteinuria in human clinical trials." | 3.69 | Model development and analysis of tenidap-induced proteinuria in the rat. ( Aleo, MD; Giebisch, G; Lopez-Anaya, A; Sanders, MJ; Walsh, AH; Wang, T, 1996) |
| "3 alpha,7 beta-Dihydroxy-23-methyl-5 beta-cholan-24-oic acid (MUDCA) and its two diastereoisomers, alpha- and beta-MUDCA, were infused intraduodenally in biliary fistula hamsters in order to evaluate the effect on bile flow and their hepatic biotransformation processes compared with the natural analog ursodeoxycholic acid (UDCA)." | 3.68 | Effect of intraduodenal administration of 23-methyl-UDCA diastereoisomers on bile flow in hamsters. ( Clerici, C; Distrutti, E; Dozzini, G; Gentili, G; Natalini, B; Pelli, MA; Pellicciari, R; Rizzoli, R; Roda, A; Sadeghpour, BM, 1992) |
| "Gastric ulceration has been induced after stress, combining 24 h of fasting and 48 h of restraint in 9 groups of 20 rats with or without a pyloroplasty or a pylorojejunostomy combined with atropine and gastric infusion of NaHCO3 or taurocholic acid." | 3.67 | Gastric stress ulcer of the rat: relative contribution of the pyloric sphincter, HCO3- bile reflux and mucosal blood flow. ( Bénichoux, R; Durlik, M; Mainard, D, 1986) |
| "Two experimental studies were carried out upon dogs to clarify the efficacy of peritoneal povidone-iodine lavage in peritonitis." | 3.66 | Peritoneal lavage with povidone-iodine solution in experimentally induced peritonitis. ( Lores, ME; Ortíz, JR; Rosselló, PJ, 1981) |
| "Ouabain-induced tachyarrhythmias in cats can be abolished by bolus injection of NaHCO3 solution." | 3.65 | Antiarrhythmic effect of hypertonic sodium bicarbonate and sodium chloride in ouabain-induced arrhythmias. ( Aryanpur, I; Paydar, M; Reyhani, F; Shakibi, JG; Siassi, B, 1976) |
| "In this model of cardiac arrest, carbicarb was not superior to sodium bicarbonate in the correction of metabolic acidosis during CPR." | 2.67 | Correction of metabolic acidosis in experimental CPR: a comparative study of sodium bicarbonate, carbicarb, and dextrose. ( Blecic, S; De Backer, D; Deleuze, M; Vachiery, JL; Vincent, JL, 1991) |
| "Pretreatment with diminazene aceturate, a small molecule with ability to inhibit acid detection through blockade of the acid-sensing ion channel (ASIC) at the doses provided, did not prevent acid-induced pathologic mucus or transport defects but did mitigate airway obstruction." | 1.56 | Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways. ( Atanasova, KR; Bravo, L; Collins, EN; Dadural, JS; Eken, E; Guevara, MV; Kuan, SP; Liao, YSJ; Reznikov, LR; Schurmann, V; Sponchiado, M; Vogt, K, 2020) |
| "Hypoxic lactic acidosis was efficiently reversed in group PR, instead of group CR, (pH 7." | 1.48 | Pyruvate in reduced osmolarity oral rehydration salt corrected lactic acidosis in sever scald rats. ( Li, ZY; Liu, R; Wang, SM; Yu, W; Zhang, HP; Zhou, FQ, 2018) |
| "Metabolic acidosis is the most common acid-base disorder in septic patients and is associated with increased mortality." | 1.48 | Monophosphoryl lipid A prevents impairment of medullary thick ascending limb [Formula: see text] absorption and improves plasma [Formula: see text] concentration in septic mice. ( George, T; Good, DW; Sherwood, ER; Watts, BA, 2018) |
| " Other two groups were the intravenous (IV) resuscitation (group VR) with lactated Ringer's solution with the same dosage and no fluid rehydration (group NR)." | 1.43 | Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs. ( Bai, XD; Guo, SJ; Hu, S; Hu, XH; Li, ZY; Liu, R; Wang, SM; Zhou, FQ, 2016) |
| "Hypoxic lactic acidosis was fully corrected in group PORS in 4 h, whereas it worsened in group BORS, and the 24-h survival rate was twice higher in group PORS than in group BORS (45." | 1.42 | Pyruvate oral rehydration solution improved visceral function and survival in shock rats. ( He, ZJ; Hu, S; Lin, HY; Luo, HM; Sheng, ZY; Xie, ZY; Yu, W; Zhou, FQ, 2015) |
| "Using our mouse model for metastatic breast cancer (MDA-MB-231), we designed an interventional survival study where tumor bearing mice received bicarbonate, DCA, or DCA-bicarbonate (DB) therapies chronically." | 1.37 | Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer. ( Martin, NK; Robey, IF, 2011) |
| "The symptoms of Dent disease are replicated in Clcn5 knock-out mice." | 1.37 | Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3). ( Cha, B; Donowitz, M; Duan, X; Guggino, SE; Hubbard, A; Hulamm, P; Jin, S; Lin, Z; Martini, S; Wang, T, 2011) |
| "We induced carious lesions in CF and wildtype mice by infecting their oral cavity with S." | 1.37 | Elevated incidence of dental caries in a mouse model of cystic fibrosis. ( Bowen, WH; Catalán, MA; Klein, MI; Koo, H; Melvin, JE; Scott-Anne, K, 2011) |
| "Pretreatment with propranolol prevented the decrease in blood glutamate concentrations seen in mild hyperthermia and did not affect the increase in blood glutamate levels seen at temperatures of 41°C and 42°C (P < 0." | 1.36 | The effect of hyperthermia on blood glutamate levels. ( Artru, AA; Dubilet, M; Gruenbaum, SE; Gurevich, B; Leibowitz, A; Ohayon, S; Shaked, G; Shapira, Y; Teichberg, VI; Zlotnik, A, 2010) |
| "Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (encoded by Cftr) that impair its role as an apical chloride channel that supports bicarbonate transport." | 1.36 | Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. ( Barrett, KE; Dennis, EA; Dong, H; Dumlao, DS; Glass, CK; Harmon, GS; Ng, DT, 2010) |
| "The appropriate treatment of acute metabolic acidosis has been very controversial." | 1.35 | Ionized alkaline water: new strategy for management of metabolic acidosis in experimental animals. ( Abol-Enein, H; Barakat, N; Gheith, OA; Nour, E; Sharaf, AE, 2009) |
| "Colitis was induced by 2,4-dinitrobenzenesulfonic acid (DNBS) or acetic acid." | 1.35 | Effects of a bicarbonate-alkaline mineral water on digestive motility in experimental models of functional and inflammatory gastrointestinal disorders. ( Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Gori, G; Tuccori, M, 2008) |
| "Cerebral edema in diabetic ketoacidosis (DKA-CE) occurs primarily in children and can develop during DKA therapy." | 1.34 | Combined insulin and bicarbonate therapy elicits cerebral edema in a juvenile mouse model of diabetic ketoacidosis. ( Fraser, DD; Pin, CL; Rose, KL; Wang, R, 2007) |
| "Here we show that hyperthermia causes respiratory alkalosis in the immature brain, with a threshold of 0." | 1.33 | Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. ( Kaila, K; Mackie, K; Rivera, C; Salmen, B; Schmitz, D; Schuchmann, S; Sipilä, ST; Vanhatalo, S; Voipio, J, 2006) |
| " Mesothelial damage, angiogenesis, and fibrosis of mesentery and parietal peritoneum as well as glucose absorption rate and ultrafiltration capacity proved to be mast cell independent." | 1.33 | Novel role for mast cells in omental tissue remodeling and cell recruitment in experimental peritoneal dialysis. ( Beelen, RH; Fabbrini, P; Hekking, LH; Keuning, ED; Ter Wee, PM; van den Born, J; Zareie, M, 2006) |
| "Administration of alkali, a treatment for rhabdomyolysis, improved renal function and significantly reduced the urinary excretion of F2-isoprostanes by approximately 80%." | 1.30 | A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. ( Anand, R; Clozel, M; Cooper, CE; Darley-Usmar, V; Goodier, D; Holt, SG; Moore, KP; Morrow, JD; Patel, RP; Reeder, BJ; Roberts, LJ; Svistunenko, DA; Wilson, MT; Zackert, W, 1998) |
| "Carbon tetrachloride (CCl4) was fed by gavage to rats, and 2, 7, 14, and 28 days later, small and large cholangiocytes were isolated." | 1.30 | Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver. ( Alpini, G; Baiocchi, L; Benedetti, A; Caligiuri, A; Francis, H; Glaser, S; Lasater, J; LeSage, GD; Marucci, L; Phinizy, JL; Rodgers, R; Tretjak, Z; Ugili, L, 1999) |
| "We conclude that untreated cardiac arrest may be accompanied by normal arterial and mixed venous blood gas levels." | 1.29 | Changes in arterial and mixed venous blood gases during untreated ventricular fibrillation and cardiopulmonary resuscitation. ( Idris, AH; Orban, DJ; Tucker, KJ; Wenzel, V, 1994) |
| "Systemic acidosis occurs during cardiac arrest and cardiopulmonary resuscitation (CPR)." | 1.28 | Effects of different dosages and modes of sodium bicarbonate administration during cardiopulmonary resuscitation. ( Bleske, BE; Chow, MS; Fieldman, A; Kluger, J; Zhao, H, 1992) |
| "An experimental model of hypertrophic pyloric stenosis was made by suture of the pyloric wall and gastrostomy in 10 rabbits under general anesthesia." | 1.28 | Hemoperfusion with a new anion exchange resin corrects the metabolic alkalosis in pyloric stenosis: an experimental demonstration. ( Balestri, M; Bonomini, V; Cianciolo, G; Colì, L; Faenza, S; Fini, M; Giardino, R; Martinelli, G; Spighi, M; Stefoni, S, 1992) |
| "We induced severe hypothermia and cardiac arrest in 15 mongrel dogs." | 1.27 | A model for the treatment of accidental severe hypothermia. ( Haklin, M; Moss, JF; Roseman, DL; Southwick, HW, 1986) |
| "Distal renal tubular acidosis has been thought to be the consequence of an impaired ability to maintain a large pH gradient between distal nephron urine and blood." | 1.26 | Mechanisms and classification of deranged distal urinary acidification. ( Arruda, JA; Kurtzman, NA, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 54 (30.68) | 18.7374 |
| 1990's | 35 (19.89) | 18.2507 |
| 2000's | 30 (17.05) | 29.6817 |
| 2010's | 50 (28.41) | 24.3611 |
| 2020's | 7 (3.98) | 2.80 |
| Authors | Studies |
|---|---|
| Berg, P | 1 |
| Andersen, JF | 1 |
| Sørensen, MV | 1 |
| Wang, T | 3 |
| Malte, H | 1 |
| Leipziger, J | 1 |
| Woodman, R | 1 |
| Miller, C | 1 |
| Student, J | 1 |
| Freeman, K | 1 |
| Perl, D | 1 |
| Lockette, W | 1 |
| Fan, SH | 1 |
| Ebner, P | 1 |
| Reichert, S | 1 |
| Hertlein, T | 1 |
| Zabel, S | 1 |
| Lankapalli, AK | 1 |
| Nieselt, K | 1 |
| Ohlsen, K | 1 |
| Götz, F | 1 |
| Liao, YSJ | 1 |
| Kuan, SP | 1 |
| Guevara, MV | 1 |
| Collins, EN | 1 |
| Atanasova, KR | 1 |
| Dadural, JS | 1 |
| Vogt, K | 1 |
| Schurmann, V | 1 |
| Bravo, L | 1 |
| Eken, E | 1 |
| Sponchiado, M | 1 |
| Reznikov, LR | 1 |
| Hyacinthe, JN | 1 |
| Buscemi, L | 1 |
| Lê, TP | 1 |
| Lepore, M | 1 |
| Hirt, L | 1 |
| Mishkovsky, M | 1 |
| Raigani, S | 1 |
| Carroll, C | 1 |
| Griffith, S | 1 |
| Pendexter, C | 1 |
| Rosales, I | 1 |
| Deirawan, H | 1 |
| Beydoun, R | 1 |
| Yarmush, M | 1 |
| Uygun, K | 1 |
| Yeh, H | 1 |
| Quade, BN | 2 |
| Marshall, A | 2 |
| Parker, MD | 3 |
| Bertelsen, LB | 2 |
| Hansen, ESS | 1 |
| Sadowski, T | 1 |
| Ruf, S | 1 |
| Laustsen, C | 3 |
| Naumann, J | 1 |
| Biehler, D | 1 |
| Lüty, T | 1 |
| Sadaghiani, C | 1 |
| Deutschmann, K | 1 |
| Reich, M | 1 |
| Klindt, C | 1 |
| Dröge, C | 1 |
| Spomer, L | 1 |
| Häussinger, D | 1 |
| Keitel, V | 1 |
| Birket, SE | 1 |
| Davis, JM | 1 |
| Fernandez, CM | 1 |
| Tuggle, KL | 1 |
| Oden, AM | 1 |
| Chu, KK | 1 |
| Tearney, GJ | 1 |
| Fanucchi, MV | 1 |
| Sorscher, EJ | 1 |
| Rowe, SM | 1 |
| Markovic, S | 1 |
| Fages, A | 1 |
| Roussel, T | 1 |
| Hadas, R | 1 |
| Brandis, A | 1 |
| Neeman, M | 1 |
| Frydman, L | 1 |
| Liu, R | 2 |
| Wang, SM | 2 |
| Li, ZY | 2 |
| Yu, W | 2 |
| Zhang, HP | 1 |
| Zhou, FQ | 3 |
| Vila Cuenca, M | 1 |
| Keuning, ED | 3 |
| Talhout, W | 1 |
| Paauw, NJ | 1 |
| van Ittersum, FJ | 1 |
| Ter Wee, PM | 3 |
| Beelen, RHJ | 1 |
| Vervloet, MG | 1 |
| Ferrantelli, E | 1 |
| Watts, BA | 2 |
| George, T | 1 |
| Sherwood, ER | 2 |
| Good, DW | 2 |
| Sun, A | 1 |
| Tang, X | 1 |
| Nie, D | 1 |
| Fan, Y | 1 |
| Tang, G | 1 |
| Abou Alaiwa, MH | 2 |
| Launspach, JL | 1 |
| Grogan, B | 1 |
| Carter, S | 1 |
| Zabner, J | 2 |
| Stoltz, DA | 2 |
| Singh, PK | 1 |
| McKone, EF | 1 |
| Welsh, MJ | 2 |
| Miszczuk, GS | 1 |
| Banales, JM | 1 |
| Zucchetti, AE | 1 |
| Pisani, GB | 1 |
| Boaglio, AC | 1 |
| Saez, E | 1 |
| Medina, JF | 1 |
| Roma, MG | 2 |
| Crocenzi, FA | 1 |
| Salerno, EE | 1 |
| Patel, SP | 1 |
| Marshall, J | 1 |
| Alsufayan, T | 1 |
| Mballo, CSA | 1 |
| Tamayo, E | 1 |
| Wilschanski, M | 1 |
| Novak, I | 1 |
| Ball, DR | 1 |
| Cruickshank, R | 1 |
| Carr, CA | 1 |
| Stuckey, DJ | 1 |
| Lee, P | 1 |
| Clarke, K | 2 |
| Tyler, DJ | 2 |
| De Lisle, RC | 1 |
| Borowitz, D | 1 |
| Orlowski, A | 1 |
| Ciancio, MC | 1 |
| Caldiz, CI | 1 |
| De Giusti, VC | 1 |
| Aiello, EA | 1 |
| Lycke, S | 1 |
| Palm, F | 1 |
| Østergaard, JA | 1 |
| Bibby, BM | 1 |
| Nørregaard, R | 2 |
| Flyvbjerg, A | 1 |
| Pedersen, M | 1 |
| Ardenkjaer-Larsen, JH | 1 |
| Song, P | 1 |
| Du, Y | 1 |
| Song, W | 1 |
| Liu, X | 2 |
| Hong, L | 1 |
| Li, H | 1 |
| Xie, H | 1 |
| Zhou, L | 1 |
| Tuo, B | 2 |
| Zheng, S | 1 |
| Hu, S | 2 |
| Xie, ZY | 1 |
| He, ZJ | 1 |
| Luo, HM | 1 |
| Lin, HY | 1 |
| Sheng, ZY | 1 |
| Bürki, R | 1 |
| Mohebbi, N | 1 |
| Bettoni, C | 1 |
| Wang, X | 1 |
| Serra, AL | 1 |
| Wagner, CA | 1 |
| Yoshihara, HA | 1 |
| Bastiaansen, JA | 1 |
| Berthonneche, C | 1 |
| Comment, A | 1 |
| Schwitter, J | 1 |
| Jin, Y | 1 |
| Bai, Y | 1 |
| Li, Q | 1 |
| Bhugul, PA | 1 |
| Huang, X | 1 |
| Liu, L | 1 |
| Pan, L | 1 |
| Ni, H | 1 |
| Chen, B | 1 |
| Sun, H | 1 |
| Zhang, Q | 1 |
| Hehir, M | 1 |
| Zhou, M | 1 |
| Boedtkjer, E | 1 |
| Bentzon, JF | 1 |
| Dam, VS | 1 |
| Aalkjaer, C | 1 |
| Hu, XH | 1 |
| Guo, SJ | 1 |
| Bai, XD | 1 |
| Nielsen, PM | 1 |
| Qi, H | 1 |
| Mikkelsen, E | 1 |
| Kristensen, ML | 1 |
| Stødkilde-Jørgensen, H | 1 |
| Fornai, M | 1 |
| Colucci, R | 1 |
| Antonioli, L | 1 |
| Ghisu, N | 1 |
| Tuccori, M | 1 |
| Gori, G | 1 |
| Blandizzi, C | 1 |
| Del Tacca, M | 1 |
| Seidler, U | 2 |
| Singh, A | 1 |
| Chen, M | 1 |
| Cinar, A | 1 |
| Bachmann, O | 1 |
| Zheng, W | 1 |
| Wang, J | 1 |
| Yeruva, S | 1 |
| Riederer, B | 2 |
| Caples, SM | 1 |
| Rasmussen, DL | 1 |
| Lee, WY | 1 |
| Wolfert, MZ | 1 |
| Hubmayr, RD | 1 |
| Tang, L | 1 |
| Fatehi, M | 1 |
| Linsdell, P | 1 |
| Wilson, AC | 1 |
| Soyer, M | 1 |
| Hoch, JA | 1 |
| Perego, M | 1 |
| Abol-Enein, H | 1 |
| Gheith, OA | 1 |
| Barakat, N | 1 |
| Nour, E | 1 |
| Sharaf, AE | 1 |
| Aarsaether, E | 1 |
| Stenberg, TA | 1 |
| Jakobsen, Ø | 1 |
| Busund, R | 1 |
| Huang, H | 1 |
| Zhang, W | 1 |
| Liu, S | 1 |
| Yanfang, C | 1 |
| Li, T | 1 |
| Liu, J | 1 |
| Harmon, GS | 1 |
| Dumlao, DS | 1 |
| Ng, DT | 1 |
| Barrett, KE | 1 |
| Dennis, EA | 1 |
| Dong, H | 1 |
| Glass, CK | 1 |
| Lee, HW | 1 |
| Verlander, JW | 1 |
| Bishop, JM | 1 |
| Nelson, RD | 1 |
| Handlogten, ME | 1 |
| Weiner, ID | 1 |
| Xing, T | 1 |
| Pilowsky, PM | 1 |
| Crajoinas, RO | 1 |
| Lessa, LM | 1 |
| Carraro-Lacroix, LR | 1 |
| Davel, AP | 1 |
| Pacheco, BP | 1 |
| Rossoni, LV | 1 |
| Malnic, G | 1 |
| Girardi, AC | 1 |
| Romero, MF | 1 |
| Nassini, R | 1 |
| Andrè, E | 1 |
| Gazzieri, D | 1 |
| De Siena, G | 1 |
| Zanasi, A | 1 |
| Geppetti, P | 1 |
| Materazzi, S | 1 |
| Twombley, K | 1 |
| Gattineni, J | 1 |
| Bobulescu, IA | 1 |
| Dwarakanath, V | 1 |
| Baum, M | 1 |
| Wesson, DE | 2 |
| Simoni, J | 1 |
| Solan, PD | 1 |
| Piraino, G | 1 |
| Hake, PW | 1 |
| Denenberg, A | 1 |
| O'Connor, M | 1 |
| Lentsch, A | 1 |
| Zingarelli, B | 1 |
| Zlotnik, A | 1 |
| Gurevich, B | 1 |
| Artru, AA | 1 |
| Gruenbaum, SE | 1 |
| Dubilet, M | 1 |
| Leibowitz, A | 1 |
| Shaked, G | 1 |
| Ohayon, S | 1 |
| Shapira, Y | 1 |
| Teichberg, VI | 1 |
| Hall, RA | 1 |
| De Sordi, L | 1 |
| Maccallum, DM | 1 |
| Topal, H | 1 |
| Eaton, R | 1 |
| Bloor, JW | 1 |
| Robinson, GK | 1 |
| Levin, LR | 1 |
| Buck, J | 1 |
| Wang, Y | 1 |
| Gow, NA | 1 |
| Steegborn, C | 1 |
| Mühlschlegel, FA | 1 |
| Lo, YF | 1 |
| Yang, SS | 1 |
| Seki, G | 1 |
| Yamada, H | 1 |
| Horita, S | 1 |
| Yamazaki, O | 1 |
| Fujita, T | 1 |
| Usui, T | 1 |
| Tsai, JD | 1 |
| Yu, IS | 1 |
| Lin, SW | 1 |
| Lin, SH | 1 |
| Catalán, MA | 1 |
| Scott-Anne, K | 1 |
| Klein, MI | 1 |
| Koo, H | 1 |
| Bowen, WH | 1 |
| Melvin, JE | 2 |
| Lin, Z | 1 |
| Jin, S | 1 |
| Duan, X | 1 |
| Martini, S | 1 |
| Hulamm, P | 1 |
| Cha, B | 1 |
| Hubbard, A | 1 |
| Donowitz, M | 1 |
| Guggino, SE | 1 |
| Xu, WM | 1 |
| Chen, J | 1 |
| Chen, H | 1 |
| Diao, RY | 1 |
| Fok, KL | 1 |
| Dong, JD | 1 |
| Sun, TT | 1 |
| Chen, WY | 1 |
| Yu, MK | 1 |
| Zhang, XH | 1 |
| Tsang, LL | 1 |
| Lau, A | 1 |
| Shi, QX | 1 |
| Shi, QH | 1 |
| Huang, PB | 1 |
| Chan, HC | 1 |
| Robey, IF | 1 |
| Martin, NK | 1 |
| Aubertin, G | 1 |
| Choquet, P | 1 |
| Dheu, C | 1 |
| Constantinesco, A | 1 |
| Ratomponirina, C | 1 |
| Zaloszyc, A | 1 |
| Passlick-Deetjen, J | 1 |
| Fischbach, M | 1 |
| Maruyama, Y | 1 |
| Chambers, DJ | 1 |
| Pezzulo, AA | 1 |
| Tang, XX | 1 |
| Hoegger, MJ | 1 |
| Ramachandran, S | 1 |
| Moninger, TO | 1 |
| Karp, PH | 1 |
| Wohlford-Lenane, CL | 1 |
| Haagsman, HP | 1 |
| van Eijk, M | 1 |
| Bánfi, B | 1 |
| Horswill, AR | 1 |
| McCray, PB | 1 |
| Song, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095] | Phase 2 | 110 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| Hyperpolarized MRSI in Ischemic Heart Disease: Metabolic Profiling of the Myocardium[NCT06054516] | 15 participants (Anticipated) | Observational | 2023-10-13 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 20 |
| Cold Blood Cardioplegia | 24 |
CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 6.0 |
| Cold Blood Cardioplegia | 7.8 |
CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 1.9 |
| Cold Blood Cardioplegia | 2.6 |
Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 24 |
| Cold Blood Cardioplegia | 30 |
Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 5.7 |
| Cold Blood Cardioplegia | 7.8 |
Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3.0 |
| Cold Blood Cardioplegia | 4.8 |
Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | .03 |
| Cold Blood Cardioplegia | .03 |
Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 18.8 |
| Cold Blood Cardioplegia | 22.2 |
Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 9.65 |
| Cold Blood Cardioplegia | 10.15 |
LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery
| Intervention | % LV volume (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | -0.06 |
| Cold Blood Cardioplegia | 1.9 |
Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | minutes (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 340 |
| Cold Blood Cardioplegia | 582 |
Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission
| Intervention | days (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3 |
| Cold Blood Cardioplegia | 3 |
Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 47 |
| Cold Blood Cardioplegia | 43 |
time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | hours (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 10.5 |
| Cold Blood Cardioplegia | 11.4 |
11 reviews available for hydrogen carbonate and Disease Models, Animal
| Article | Year |
|---|---|
Prevention and Therapy of Type 2 Diabetes-What Is the Potential of Daily Water Intake and Its Mineral Nutrients?
Topics: Adolescent; Adult; Aged; Animals; Bicarbonates; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2 | 2017 |
Bile acid receptors in the biliary tree: TGR5 in physiology and disease.
Topics: Animals; Bicarbonates; Bile Acids and Salts; Bile Ducts; Cell Proliferation; Cholangitis; Cysts; Dis | 2018 |
Mouse models of SLC4-linked disorders of HCO
Topics: Acid-Base Equilibrium; Animals; Bicarbonates; Disease Models, Animal; Genetic Predisposition to Dise | 2018 |
The cystic fibrosis of exocrine pancreas.
Topics: Animals; Bicarbonates; Chloride Channels; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2013 |
The cystic fibrosis intestine.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease | 2013 |
Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension.
Topics: Animals; Bicarbonates; Biological Transport; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conducta | 2009 |
[Experimental provocation of panic attacks as a human experimental model for anxiety].
Topics: Anxiety Disorders; Atrial Natriuretic Factor; Bicarbonates; Caffeine; Disease Models, Animal; Lactat | 2003 |
Chloride channels and cystic fibrosis of the pancreas.
Topics: Animals; Bicarbonates; Chloride Channels; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 1995 |
A reconsideration of the evidence for Escherichia coli STa (heat stable) enterotoxin-driven fluid secretion: a new view of STa action and a new paradigm for fluid absorption.
Topics: Animals; Anti-Bacterial Agents; Bacterial Toxins; Bicarbonates; Biological Transport; Carbon Dioxide | 2001 |
Bicarbonate secretion in the murine gallbladder--lessons for the treatment of cystic fibrosis.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease | 2001 |
New concepts in experimental peptic ulceration.
Topics: Animals; Bicarbonates; Disease Models, Animal; Duodenal Ulcer; Gastric Acid | 1991 |
1 trial available for hydrogen carbonate and Disease Models, Animal
| Article | Year |
|---|---|
Correction of metabolic acidosis in experimental CPR: a comparative study of sodium bicarbonate, carbicarb, and dextrose.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Blood Gas Analysis; Carbonates; Clinical Protocols; Disease | 1991 |
164 other studies available for hydrogen carbonate and Disease Models, Animal
| Article | Year |
|---|---|
Alkalosis-induced hypoventilation in cystic fibrosis: The importance of efficient renal adaptation.
Topics: Acid-Base Equilibrium; Alkalosis; Animals; Bicarbonates; Chloride-Bicarbonate Antiporters; Cystic Fi | 2022 |
Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury.
Topics: alpha-Methyltyrosine; Animals; Bicarbonates; Brain Injuries, Traumatic; Catecholamines; Chlorides; D | 2023 |
MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO
Topics: Animals; Bacterial Proteins; Bicarbonates; Carbon Dioxide; Carbonic Anhydrases; Disease Models, Anim | 2019 |
Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Airway Obstruction; Anima | 2020 |
Evaluating the potential of hyperpolarised [1-
Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis | 2020 |
Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content.
Topics: Animals; Bicarbonates; Cytokines; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; L | 2020 |
pH dependence of the Slc4a11-mediated H
Topics: Animals; Animals, Genetically Modified; Anion Transport Proteins; Bicarbonates; Biological Transport | 2020 |
Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney.
Topics: Alanine; Animals; Bicarbonates; Disease Models, Animal; Enzyme Activation; Glucose; Glycolysis; Hema | 2021 |
Development of an airway mucus defect in the cystic fibrosis rat.
Topics: Animals; Bicarbonates; Biological Transport; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conducta | 2018 |
Placental physiology monitored by hyperpolarized dynamic
Topics: Animals; Bicarbonates; Carbon Isotopes; Disease Models, Animal; Female; Humans; Lactic Acid; Magneti | 2018 |
Pyruvate in reduced osmolarity oral rehydration salt corrected lactic acidosis in sever scald rats.
Topics: Acidosis, Lactic; Administration, Oral; Animals; Bicarbonates; Burns; Citric Acid; Disease Models, A | 2018 |
Differences in peritoneal response after exposure to low-GDP bicarbonate/lactate-buffered dialysis solution compared to conventional dialysis solution in a uremic mouse model.
Topics: Actins; Animals; Bicarbonates; Buffers; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Chemokine | 2018 |
Monophosphoryl lipid A prevents impairment of medullary thick ascending limb [Formula: see text] absorption and improves plasma [Formula: see text] concentration in septic mice.
Topics: Acid-Base Equilibrium; Acidosis; Adaptor Proteins, Vesicular Transport; Animals; Bicarbonates; Disea | 2018 |
Positron Emission Tomography Imaging of Lesions pH Using
Topics: Acetazolamide; Animals; Bicarbonates; Carbon Radioisotopes; Carbonic Anhydrase Inhibitors; Cell Line | 2018 |
Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis.
Topics: Adult; Aminophenols; Animals; Bicarbonates; Biological Transport, Active; Bronchoalveolar Lavage Flu | 2018 |
Adaptive downregulation of Cl-/HCO3- exchange activity in rat hepatocytes under experimental obstructive cholestasis.
Topics: Animals; Bicarbonates; Chloride-Bicarbonate Antiporters; Chlorides; Cholestasis; Disease Models, Ani | 2019 |
Extrarenal Signs of Proximal Renal Tubular Acidosis Persist in Nonacidemic Nbce1b/c-Null Mice.
Topics: Acidosis; Acidosis, Renal Tubular; Acidosis, Respiratory; Analysis of Variance; Animals; Bicarbonate | 2019 |
Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through induction of Tollip and negative regulation of IRAK-1.
Topics: Adaptor Proteins, Vesicular Transport; Adjuvants, Immunologic; Animals; Bicarbonates; Cytoprotection | 2019 |
Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13C]pyruvate.
Topics: Animals; Bicarbonates; Carbon Isotopes; Disease Models, Animal; Energy Metabolism; Heart; In Vitro T | 2013 |
Reduced sarcolemmal expression and function of the NBCe1 isoform of the Na⁺-HCO₃⁻ cotransporter in hypertrophied cardiomyocytes of spontaneously hypertensive rats: role of the renin-angiotensin system.
Topics: Ammonium Compounds; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensi | 2014 |
High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-(13)C]pyruvate magnetic resonance imaging.
Topics: Alanine; Altitude; Altitude Sickness; Animals; Atmospheric Pressure; Bicarbonates; Blood Glucose; Di | 2014 |
Bile deficiency induces changes in intestinal Cl(-) and HCO3 (-) secretions in mice.
Topics: Animals; Bicarbonates; Blotting, Western; Chlorides; Cholestasis; Cystic Fibrosis Transmembrane Cond | 2014 |
Pyruvate oral rehydration solution improved visceral function and survival in shock rats.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Disease Models, Animal; Fluid Therapy; Glucose; Lipid Perox | 2015 |
Impaired expression of key molecules of ammoniagenesis underlies renal acidosis in a rat model of chronic kidney disease.
Topics: Acidosis; Amino Acid Transport Systems, Neutral; Ammonia; Animals; Bicarbonates; Creatinine; Disease | 2015 |
An intact small animal model of myocardial ischemia-reperfusion: Characterization of metabolic changes by hyperpolarized 13C MR spectroscopy.
Topics: Alanine; Animals; Bicarbonates; Carbon Isotopes; Disease Models, Animal; Hemodynamics; Inflammation; | 2015 |
Reduced Pancreatic Exocrine Function and Organellar Disarray in a Canine Model of Acute Pancreatitis.
Topics: Acute Disease; Amylases; Animals; Bicarbonates; Disease Models, Animal; Dogs; Extracellular Fluid; L | 2016 |
Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling.
Topics: Animals; Bicarbonates; Carbon Dioxide; Carotid Artery Injuries; Carotid Artery, Common; Cell Movemen | 2016 |
Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs.
Topics: Animals; Bicarbonates; Burns; Capillary Permeability; Disease Models, Animal; Dogs; Fluid Therapy; F | 2016 |
In situ lactate dehydrogenase activity: a novel renal cortical imaging biomarker of tubular injury?
Topics: Acute Kidney Injury; Alanine; Animals; Bicarbonates; Biomarkers; Carbon Isotopes; Disease Models, An | 2017 |
Effects of a bicarbonate-alkaline mineral water on digestive motility in experimental models of functional and inflammatory gastrointestinal disorders.
Topics: Animals; Benzodiazepinones; Bicarbonates; Colitis; Constipation; Diarrhea; Disease Models, Animal; G | 2008 |
Impact of buffering hypercapnic acidosis on cell wounding in ventilator-injured rat lungs.
Topics: Acidosis; Acute Lung Injury; Animals; Bicarbonates; Buffers; Cell Membrane; Cells, Cultured; Disease | 2009 |
Mechanism of direct bicarbonate transport by the CFTR anion channel.
Topics: Animals; Bicarbonates; Chlorides; Cricetinae; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduct | 2009 |
The bicarbonate transporter is essential for Bacillus anthracis lethality.
Topics: Animals; Anthrax; ATP-Binding Cassette Transporters; Bacillus anthracis; Bacterial Proteins; Bicarbo | 2008 |
Ionized alkaline water: new strategy for management of metabolic acidosis in experimental animals.
Topics: Acidosis; Administration, Oral; Animals; Bicarbonates; Carbon Dioxide; Disease Models, Animal; Dogs; | 2009 |
Mechanoenergetic function and troponin T release following cardioplegic arrest induced by St Thomas' and histidine-tryptophan-ketoglutarate cardioplegia--an experimental comparative study in pigs.
Topics: Animals; Bicarbonates; Biomarkers; Calcium Chloride; Cardioplegic Solutions; Cardiopulmonary Bypass; | 2009 |
Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats.
Topics: Anesthetics, Inhalation; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine K | 2010 |
Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice.
Topics: Animals; Bicarbonates; Carbonic Anhydrase II; Carbonic Anhydrase IV; Colon; Cystic Fibrosis; Cystic | 2010 |
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.
Topics: Acidosis; Adaptation, Physiological; Ammonia; Animals; Bicarbonates; Cation Transport Proteins; Dise | 2010 |
Acute intermittent hypoxia in rat in vivo elicits a robust increase in tonic sympathetic nerve activity that is independent of respiratory drive.
Topics: Action Potentials; Acute Disease; Animals; Baroreflex; Bicarbonates; Blood Pressure; Carbon Dioxide; | 2010 |
Posttranslational mechanisms associated with reduced NHE3 activity in adult vs. young prehypertensive SHR.
Topics: Absorption; Aging; Animals; Bicarbonates; Blood Pressure; Dipeptidyl Peptidase 4; Disease Models, An | 2010 |
SNPs of metabolism, not stones.
Topics: Absorption; Animals; Bicarbonates; Dicarboxylic Acid Transporters; Disease Models, Animal; Humans; K | 2010 |
A bicarbonate-alkaline mineral water protects from ethanol-induced hemorrhagic gastric lesions in mice.
Topics: Aldehydes; Animals; Bicarbonates; Dinoprostone; Disease Models, Animal; Ethanol; Gastric Mucosa; Gas | 2010 |
Effect of metabolic acidosis on neonatal proximal tubule acidification.
Topics: Acidosis; Adaptation, Physiological; Amiloride; Animals; Animals, Newborn; Bicarbonates; Disease Mod | 2010 |
Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet.
Topics: Acid-Base Equilibrium; Acidosis; Administration, Oral; Aldosterone; Animals; Bicarbonates; Calcium G | 2010 |
Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.
Topics: Animals; Bicarbonates; Chemokine CCL2; Chemokine CCL3; Cholesterol; Disease Models, Animal; Hydrocar | 2011 |
The effect of hyperthermia on blood glutamate levels.
Topics: Adrenergic beta-Antagonists; Animals; Autonomic Nervous System; Bicarbonates; Blood Glucose; Body Te | 2010 |
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
Topics: Adenylyl Cyclases; Animals; Bicarbonates; Biomass; Blotting, Southern; Blotting, Western; Candida al | 2010 |
Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis.
Topics: Acidosis; Acidosis, Renal Tubular; Age Factors; Aging; Analysis of Variance; Anemia; Animals; Aquapo | 2011 |
Elevated incidence of dental caries in a mouse model of cystic fibrosis.
Topics: Animals; Bicarbonates; Carbohydrate Metabolism; Cystic Fibrosis; Dental Caries; Disease Models, Anim | 2011 |
Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).
Topics: Animals; Bicarbonates; Cell Line; Chloride Channels; Dent Disease; Disease Models, Animal; Endocytos | 2011 |
Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia.
Topics: Adenylyl Cyclases; Adult; Animals; Azoospermia; Bicarbonates; Blotting, Western; Cyclic AMP; Cyclic | 2011 |
Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Bicarbonates; Breast Neoplasms; Cell Hypoxia; | 2011 |
The impact of dialysis solution biocompatibility on ultrafiltration and on free water transport in rats.
Topics: Animals; Bicarbonates; Biocompatible Materials; Biological Transport; Dialysis Solutions; Disease Mo | 2012 |
Ischaemic postconditioning: does cardioplegia influence protection?
Topics: Animals; Bicarbonates; Calcium Chloride; Coronary Circulation; Disease Models, Animal; Heart Arrest, | 2012 |
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.
Topics: Animals; Animals, Newborn; Anti-Infective Agents; Bicarbonates; Body Fluids; Cystic Fibrosis; Cystic | 2012 |
Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct.
Topics: Animals; Antiporters; Bicarbonates; Chlorides; Cystic Fibrosis; Disease Models, Animal; Gene Deletio | 2012 |
Bicarbonate modulates oxidative and functional damage in ischemia-reperfusion.
Topics: Animals; Bicarbonates; Buffers; Caenorhabditis elegans; Carbon Dioxide; Cell Survival; Cells, Cultur | 2013 |
Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Carbon Isotopes; Cardiac Pacing, Artificial; Cardiac | 2013 |
Buffer administration during CPR promotes cerebral reperfusion after return of spontaneous circulation and mitigates post-resuscitation cerebral acidosis.
Topics: Acidosis; Animals; Bicarbonates; Brain; Buffers; Carbon Dioxide; Cardiopulmonary Resuscitation; Cere | 2002 |
Attenuation of ischemia/reperfusion injury by N-acetylcysteine in a rat hind limb model.
Topics: Acetylcysteine; Animals; Bicarbonates; Constriction; Creatine Kinase; Dimethyl Sulfoxide; Disease Mo | 2003 |
Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity.
Topics: Animals; Animals, Newborn; Bicarbonates; Bicuculline; Carbonic Anhydrase Inhibitors; Disease Models, | 2003 |
The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium.
Topics: Animals; Bicarbonates; Carbon Dioxide; Coronary Circulation; Disease Models, Animal; In Vitro Techni | 2004 |
Anti-inflammatory effects of topical ocular MAXIDEX administration to rabbits following vitrectomy or lensectomy.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Bicarbonates; Blood-Aqueous Barrier; Corneal Edema; Dex | 2004 |
Carbon dioxide pneumoperitoneum causes severe peritoneal acidosis, unaltered by heating, humidification, or bicarbonate in a porcine model.
Topics: Acidosis; Animals; Bicarbonates; Carbon Dioxide; Disease Models, Animal; Hot Temperature; Humidity; | 2004 |
Improved biocompatibility of bicarbonate/lactate-buffered PDF is not related to pH.
Topics: Animals; Bicarbonates; Buffers; Dialysis Solutions; Disease Models, Animal; Hydrogen-Ion Concentrati | 2006 |
Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion.
Topics: Animals; Antiporters; Bicarbonates; Carbachol; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmemb | 2006 |
Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis.
Topics: Acclimatization; Acidosis; Animals; Bicarbonates; Biological Transport; Cell Polarity; Chlorides; Di | 2006 |
Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis.
Topics: Alkalosis, Respiratory; Animals; Bicarbonates; Body Temperature; Brain; Carbon Dioxide; Disease Mode | 2006 |
Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Bicarbonates; Disease Models, Animal; Humans; Hydrogen Peroxide; Models, B | 2006 |
Serotonin increases protective duodenal bicarbonate secretion via enteric ganglia and a 5-HT4-dependent pathway.
Topics: Animals; Bicarbonates; Buffers; Calcium Signaling; Disease Models, Animal; Duodenum; Enterocytes; Hu | 2006 |
Novel role for mast cells in omental tissue remodeling and cell recruitment in experimental peritoneal dialysis.
Topics: Angiogenesis Inhibitors; Animals; Bicarbonates; Cromolyn Sodium; Dialysis Solutions; Disease Models, | 2006 |
Effects of 5-hydroxytryptamine on the short-circuit current across the small intestine of the gerbil (Gerbillus cheesmani) in different dietary states.
Topics: Animal Nutritional Physiological Phenomena; Animals; Bicarbonates; Chlorides; Disease Models, Animal | 2007 |
Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model.
Topics: Absorption; Acids; Animals; Anion Transport Proteins; Bicarbonates; Calcium; Cochlea; Deafness; Dise | 2007 |
Combined insulin and bicarbonate therapy elicits cerebral edema in a juvenile mouse model of diabetic ketoacidosis.
Topics: Animals; Bicarbonates; Brain Edema; Child; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; D | 2007 |
Acute inflammation alters bicarbonate transport in mouse ileum.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acute Disease; Adenylyl Cyclases; Animals; Antibod | 2007 |
Exocrine pancreatic secretion in rats treated with reserpine after stimulation with pilocarpine, dopamine, and caerulein.
Topics: Amylases; Animals; Bicarbonates; Ceruletide; Chlorides; Cystic Fibrosis; Disease Models, Animal; Dop | 1980 |
Secondary hypocapnia fails to protect "whole body" intracellular pH during chronic HCl-acidosis in the dog.
Topics: Acidosis; Animals; Bicarbonates; Body Fluids; Body Water; Body Weight; Carbon Dioxide; Chlorides; Di | 1983 |
Relative effects of systemic pH, PCO2, and bicarbonate concentration on ileal ion transport.
Topics: Acid-Base Imbalance; Animals; Bicarbonates; Biological Transport, Active; Carbon Dioxide; Disease Mo | 1983 |
Tubular handling of bicarbonate in dogs with experimental renal failure.
Topics: Acute Kidney Injury; Animals; Bicarbonates; Chlorides; Disease Models, Animal; Dogs; Female; Kidney | 1984 |
Hypophosphaturia impairs the renal defense against metabolic acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Bicarbonates; Chlorides; Creatinine; Disease Models, Anima | 1984 |
Altered bicarbonate reabsorption in the pancreas of reserpine-treated rabbits--a model for cystic fibrosis.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Disease Models, Animal; Male; Pancreatic Juice; Rabbits; Res | 1983 |
Peritoneal lavage with povidone-iodine solution in experimentally induced peritonitis.
Topics: Acidosis; Animals; Bicarbonates; Disease Models, Animal; Dogs; Female; Humans; Ileum; Ligation; Peri | 1981 |
Experimental urolithiasis: Part V-Role of dietary carbonate in the etiology of the disease using radioactive 14C-potassium bicarbonate.
Topics: Administration, Oral; Animals; Bicarbonates; Carbon Radioisotopes; Disease Models, Animal; Kidney; M | 1980 |
Mechanisms and classification of deranged distal urinary acidification.
Topics: Acidosis, Renal Tubular; Aldosterone; Animals; Bicarbonates; Disease Models, Animal; Electrolytes; H | 1980 |
Canine model of chronic pancreatitis due to chronic ischemia.
Topics: Amylases; Animals; Bicarbonates; Chronic Disease; Disease Models, Animal; Dogs; Fibrosis; Ischemia; | 1994 |
Colchicine does not inhibit secretin-induced choleresis in rats exhibiting hyperplasia of bile ductules: evidence against a pivotal role of exocytic vesicle insertion.
Topics: Animals; Bicarbonates; Bile; Bile Ducts; Colchicine; Disease Models, Animal; Epithelium; Exocytosis; | 1995 |
Failure of prophylactic and therapeutic use of a murine anti-tumor necrosis factor monoclonal antibody in Escherichia coli sepsis in the rabbit.
Topics: Animals; Antibodies, Monoclonal; Bicarbonates; Blood Pressure; Disease Models, Animal; Drug Evaluati | 1995 |
Changes in arterial and mixed venous blood gases during untreated ventricular fibrillation and cardiopulmonary resuscitation.
Topics: Acid-Base Equilibrium; Animals; Arteries; Bicarbonates; Blood Gas Analysis; Cardiopulmonary Resuscit | 1994 |
Continuous arteriovenous hemofiltration does not improve survival in a canine model of septic shock.
Topics: Animals; Bicarbonates; Blood Pressure; Cardiac Output; Disease Models, Animal; Dogs; Escherichia col | 1995 |
Tolerance of the developing heart to ischemia: impact of hypoxemia from birth.
Topics: Age Factors; Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Crea | 1995 |
Time course of perfusion-induced myocardial edema resolution in rats.
Topics: Animals; Bicarbonates; Body Water; Calcium Chloride; Disease Models, Animal; Edema, Cardiac; Magnesi | 1994 |
Asynchrony in circadian rhythms of gastric function in the rat. A model for gastric mucosal injury.
Topics: Animals; Aspirin; Bicarbonates; Cimetidine; Circadian Rhythm; Disease Models, Animal; Epoprostenol; | 1994 |
The effect of sodium bicarbonate administration on the vasopressor effect of high-dose epinephrine during cardiopulmonary resuscitation in swine.
Topics: Acidosis; Animals; Aorta; Bicarbonates; Blood Gas Analysis; Blood Pressure; Cardiopulmonary Resuscit | 1993 |
Intracerebroventricular neuropeptide Y increases gastric and pancreatic secretion in the dog.
Topics: Analysis of Variance; Animals; Bicarbonates; Disease Models, Animal; Dogs; Eating; Female; Gastric A | 1993 |
Bicarbonate and citrate in oral rehydration therapy: studies in a model of secretory diarrhea.
Topics: Animals; Antacids; Bicarbonates; Cholera Toxin; Citrates; Citric Acid; Diarrhea; Disease Models, Ani | 1993 |
Acid-base disturbances in the rabbit during experimental hepatic parasitosis.
Topics: Acid-Base Imbalance; Animals; Bicarbonates; Blood Gas Monitoring, Transcutaneous; Coccidiosis; Disea | 1996 |
Importance of gastrin-releasing peptide on acid-induced secretin release and pancreaticobiliary and duodenal bicarbonate secretion.
Topics: Animals; Bicarbonates; Bombesin; Disease Models, Animal; Drug Interactions; Duodenum; Female; Gastri | 1996 |
Model development and analysis of tenidap-induced proteinuria in the rat.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicarbonates; Disease Models, Animal; Do | 1996 |
Characterization of a sterile soft-tissue inflammation model in thoroughbred horses.
Topics: Animals; Bicarbonates; Carbon Dioxide; Diffusion Chambers, Culture; Dinoprostone; Disease Models, An | 1996 |
Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice.
Topics: Animals; Bicarbonates; Biological Transport, Active; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 1997 |
Advantages of continuous hyperpolarized arrest with pinacidil over St. Thomas' Hospital solution during prolonged ischemia.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Body Water; Calcium Chloride; Cardioplegic Solutions; C | 1998 |
Function of adult pig hearts after 2 and 12 hours of cold cardioplegic preservation.
Topics: Animals; Bicarbonates; Blood; Calcium Chloride; Cardiac Catheterization; Cardiac Output; Cardioplegi | 1998 |
Experimental study on the scavenging effects of ginsenosides on oxygen free radicals using model of heterotopic heart transplantation in rats.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Disease Models, Animal; Female; Fre | 1998 |
A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure.
Topics: Animals; Bicarbonates; Dinoprost; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Glyc | 1998 |
Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver.
Topics: Animals; Apoptosis; Bicarbonates; Bile; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Cell Divisio | 1999 |
Low-potassium University of Wisconsin solution for cardioplegia: improved protection of the isolated ischemic neonatal rabbit heart.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Animals, Newborn; Bicarbonates; Calcium Chl | 1999 |
The effect of sodium bicarbonate on propranolol-induced cardiovascular toxicity in a canine model.
Topics: Animals; Bicarbonates; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Dogs; Electr | 2000 |
Short sequence repeat polymorphism in the mouse slc4al gene encoding the AE1 Cl-/HCO3-exchanger.
Topics: Acidosis, Renal Tubular; Animals; Antiporters; Bicarbonates; Chloride-Bicarbonate Antiporters; Chlor | 2000 |
Long-term ammonium chloride or sodium bicarbonate treatment in two models of polycystic kidney disease.
Topics: Ammonia; Ammonium Chloride; Animals; Bicarbonates; Disease Models, Animal; Female; Fibrosis; Inflamm | 2001 |
Calcium metabolism of brain in acute renal failure. Effects of uremia, hemodialysis, and parathyroid hormone.
Topics: Acute Disease; Acute Kidney Injury; Animals; Bicarbonates; Brain; Calcium; Citric Acid; Creatinine; | 1974 |
Metabolic studies in experimental renal dysfunction resulting from maleate administration.
Topics: Acetoacetates; Animals; Bicarbonates; Calcium; Coenzyme A; Disease Models, Animal; Fanconi Syndrome; | 1975 |
Lactic acidosis: an experimental model.
Topics: Acidosis; Animals; Bicarbonates; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Disease Mod | 1976 |
[Influence of metabolic alkalosis on adrenaline hyperglycemia of the dog].
Topics: Alkalosis; Animals; Bicarbonates; Depression, Chemical; Disease Models, Animal; Dogs; Epinephrine; H | 1976 |
Cerebral hemodynamic and metabolic alterations in stroke.
Topics: Animals; Basal Ganglia; Bicarbonates; Brain; Carbon Dioxide; Cats; Cerebrovascular Disorders; Diseas | 1977 |
Methyl alcohol poisoning. II. Development of a model for ocular toxicity in methyl alcohol poisoning using the rhesus monkey.
Topics: Acidosis; Animals; Bicarbonates; Carbon Dioxide; Disease Models, Animal; Eye Diseases; Formates; Hap | 1977 |
Acute response to acid-base stress.
Topics: Acid-Base Imbalance; Animals; Bicarbonates; Carbon Dioxide; Cardiopulmonary Bypass; Disease Models, | 1978 |
[Analysis of the mechanism of action of carbonic acid on tissue chemoreceptors].
Topics: Acid-Base Imbalance; Acidosis; Acidosis, Respiratory; Animals; Bicarbonates; Blood Pressure; Carbona | 1978 |
pH and bicarbonate effects on mitochondrial anion accumulation. Proposed mechanism for changes in renal metabolite levels in acute acid-base disturbances.
Topics: Acid-Base Imbalance; Animals; Bicarbonates; Citrates; Disease Models, Animal; Dogs; Formates; Hydrog | 1979 |
Intestinal absorption and electrolyte absorption.
Topics: Animals; Bicarbonates; Biological Transport, Active; Chlorides; Disease Models, Animal; Dogs; Humans | 1975 |
Cerebrospinal fluid acidosis complicating therapy of experimental cardiopulmonary arrest.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Bicarbonates; Blood Pressure; Blood-Brain Barrier; Brain D | 1975 |
Antiarrhythmic effect of hypertonic sodium bicarbonate and sodium chloride in ouabain-induced arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Cats; Disease Models, Animal; Electrocardiography; Mann | 1976 |
A new model of stress ulcer in the rat with pylorus ligation and its pathogenesis.
Topics: Amylopectin; Animals; Atropine; Bicarbonates; Chlorpromazine; Disease Models, Animal; Gastric Mucosa | 1976 |
Effect of irradiation on the canine exocrine pancreas.
Topics: Animals; Bicarbonates; Cholecystokinin; Disease Models, Animal; Dogs; Female; Male; Pancreas; Pancre | 1976 |
Exocrine pancreatic dysfunction in guinea pigs with diabetes mellitus.
Topics: Amylases; Animals; Bicarbonates; Blood Glucose; Cholecystokinin; Diabetes Mellitus; Disease Models, | 1975 |
The mechanism of myocardial protection from ischemic arrest by intracoronary tetrodotoxin administration.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Buffers; Coronary Disease; Disease Models, Animal; He | 1975 |
Steroid-induced polycystic kidneys in the newborn rat.
Topics: Animals; Animals, Newborn; Bicarbonates; Disease Models, Animal; Electrolytes; Female; Kidney Diseas | 1976 |
Effects of different dosages and modes of sodium bicarbonate administration during cardiopulmonary resuscitation.
Topics: Acidosis; Animals; Bicarbonates; Blood; Carbon Dioxide; Cardiopulmonary Resuscitation; Disease Model | 1992 |
Bile salt-associated electrolyte secretion. A study following a short-term biliary obstruction in the rat.
Topics: Animals; Bicarbonates; Bile; Bile Acids and Salts; Cholestasis; Disease Models, Animal; Male; Rats; | 1992 |
Hemoperfusion with a new anion exchange resin corrects the metabolic alkalosis in pyloric stenosis: an experimental demonstration.
Topics: Alkalosis; Animals; Anion Exchange Resins; Bicarbonates; Chlorides; Disease Models, Animal; Electrol | 1992 |
Limulus antilipopolysaccharide factor protects rabbits from meningococcal endotoxin shock.
Topics: Animals; Anti-Infective Agents; Anticoagulants; Antimicrobial Cationic Peptides; Arthropod Proteins; | 1992 |
Effect of intraduodenal administration of 23-methyl-UDCA diastereoisomers on bile flow in hamsters.
Topics: Acute Disease; Animals; Bicarbonates; Bile; Biliary Fistula; Biotransformation; Cricetinae; Disease | 1992 |
Initial pathophysiological changes in chronic pancreatitis induced by pancreatic ductular obstruction model.
Topics: Amylases; Animals; Bicarbonates; Chronic Disease; Constriction, Pathologic; Disease Models, Animal; | 1991 |
Long-term local effects of intraosseous infusion on tibial bone marrow in the weanling pig model.
Topics: Animals; Bicarbonates; Blood Cell Count; Bone and Bones; Bone Marrow; Bone Marrow Cells; Disease Mod | 1992 |
Buffer agents do not reverse intramyocardial acidosis during cardiac resuscitation.
Topics: Acidosis; Animals; Bicarbonates; Blood; Buffers; Carbon Dioxide; Carbonates; Disease Models, Animal; | 1990 |
Chronic hypoxia in neuronal cell culture: metabolic consequences.
Topics: Alanine; Animals; Bicarbonates; Binding, Competitive; Brain Chemistry; Cell Hypoxia; Cells, Cultured | 1990 |
Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation.
Topics: Acetylcholine; Animals; Atropine; Bethanechol Compounds; Bicarbonates; Chlorides; Diarrhea; Disease | 1990 |
Effect of aortic balloon inflation on ventilation and brain stem blood flow in piglets.
Topics: Animals; Animals, Newborn; Aorta; Bicarbonates; Blood Pressure; Brain Stem; Carbon Dioxide; Denervat | 1989 |
Augmented bicarbonate reabsorption by both the proximal and distal nephron maintains chloride-deplete metabolic alkalosis in rats.
Topics: Absorption; Acid-Base Equilibrium; Alkalosis; Animals; Arteries; Bicarbonates; Blood Pressure; Chlor | 1989 |
Experimental folic acid nephropathy.
Topics: Ammonium Chloride; Animals; Bicarbonates; Disease Models, Animal; Female; Folic Acid; Kidney; Kidney | 1987 |
Acute intestinal infarction or obstruction: search for better laboratory tests in an animal model.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Glucosidases; Animals; Aspartate Aminotransferases | 1988 |
A model for the treatment of accidental severe hypothermia.
Topics: Accidents; Animals; Bicarbonates; Body Temperature; Cardiac Output; Crystalloid Solutions; Disease M | 1986 |
Gastric stress ulcer of the rat: relative contribution of the pyloric sphincter, HCO3- bile reflux and mucosal blood flow.
Topics: Animals; Atropine; Bicarbonates; Bile Reflux; Biliary Tract Diseases; Blood Flow Velocity; Disease M | 1986 |
[Effects of KT1-32 on acute gastric lesions and duodenal ulcers induced in rats].
Topics: Animals; Anti-Ulcer Agents; Azulenes; Bicarbonates; Disease Models, Animal; Duodenal Ulcer; Gastric | 1986 |
Prostaglandin synthetase inhibition in group B streptococcal shock: hematologic and hemodynamic effects.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bicarbonates; Blood Gas Analysis; Blood Platelets; Blood Pres | 1986 |
Acid-base balance in a canine model of cardiac arrest.
Topics: Acidosis; Animals; Bicarbonates; Blood; Carbon Dioxide; Cerebrospinal Fluid; Coronary Circulation; D | 1988 |
[The effect of secretin on the cysteamine induced inhibition of alkaline secretion by the duodenal mucosa].
Topics: Animals; Bicarbonates; Cysteamine; Disease Models, Animal; Duodenal Ulcer; Duodenum; Intestinal Muco | 1986 |
Induction of duodenal ulcers in rats under water-immersion stress conditions. Influence of stress on gastric acid and duodenal alkaline secretion.
Topics: Animals; Bicarbonates; Disease Models, Animal; Duodenal Ulcer; Duodenum; Gastric Acid; Immersion; Ma | 1986 |
Validation of the difference in urine and blood carbon dioxide tension during bicarbonate loading as an index of distal nephron acidification in experimental models of distal renal tubular acidosis.
Topics: Absorption; Acid-Base Equilibrium; Acidosis, Renal Tubular; Amphotericin B; Animals; Bicarbonates; C | 1985 |
Evidence for a detrimental effect of bicarbonate therapy in hypoxic lactic acidosis.
Topics: Acidosis; Animals; Bicarbonates; Disease Models, Animal; Dogs; Hemodynamics; Hydrogen-Ion Concentrat | 1985 |
Study of pathogenesis of enteric Escherichia coli infection in model experiments on rabbits.
Topics: Animals; Bacillus; Bicarbonates; Cecum; Cell Count; Clostridium; Disease Models, Animal; Enteritis; | 1972 |
Relation between changes in the acid-base and the energy metabolism of the brain in hepatic coma.
Topics: Acid-Base Equilibrium; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anima | 1971 |
Physiology of status epilepticus in primates.
Topics: Alkaloids; Animals; Bicarbonates; Blood Glucose; Blood Pressure; Blood Proteins; Body Temperature; B | 1973 |
Recent advances in the understanding of anaesthetic-induced malignant hyperpyrexia.
Topics: Acidosis; Anesthetics; Animals; Anura; Bicarbonates; Caffeine; Calcium; Cold Temperature; Disease Mo | 1973 |
Effects of isoproterenol during hemorrhagic shock in the rat.
Topics: Animals; Behavior, Animal; Bicarbonates; Blood Pressure; Body Temperature; Disease Models, Animal; D | 1973 |
[Blood gas analysis and enzyme findings in tourniquet-induced ischemia].
Topics: Adult; Aged; Animals; Aspartate Aminotransferases; Bicarbonates; Blood Gas Analysis; Carbon Dioxide; | 1973 |
Acute renal failure in the rat after folate intoxication: diagnostic value of lactate dehydrogenase and alkaline phosphatase measurements in serum and urine.
Topics: Acute Kidney Injury; Alkaline Phosphatase; Animals; Bicarbonates; Disease Models, Animal; Electropho | 1974 |
[Antibacterial action of erythromycin on experimental E. coli cystitis during alkalinization of the urine in rats].
Topics: Ammonium Chloride; Animals; Bacteriuria; Bicarbonates; Cystitis; Disease Models, Animal; Erythromyci | 1970 |
[Antibacterial action of erythromycin on experimental E. coli cystitis during alkalinization of the urine in rats].
Topics: Ammonium Chloride; Animals; Bacteriuria; Bicarbonates; Cystitis; Disease Models, Animal; Erythromyci | 1970 |
Response of the subhuman primate in gram-negative septicemia induced by live Escherichia coli.
Topics: Animals; Anuria; Bicarbonates; Blood Glucose; Blood Pressure; Brain; Cardiovascular System; Disease | 1971 |
Acute response to acid-base stress in the dog.
Topics: Acidosis; Alkalosis; Ammonium Chloride; Animals; Bicarbonates; Blood; Carbon Dioxide; Computers; Dis | 1972 |
An experimental model of amphotericin B nephrotoxicity with renal tubular acidosis.
Topics: Acidosis, Renal Tubular; Ammonium Chloride; Amphotericin B; Animals; Bicarbonates; Bile Acids and Sa | 1971 |
Small bowel morphology in experimental canine cholera. A light and electron microscopic study.
Topics: Acid-Base Equilibrium; Animals; Bicarbonates; Carbon Dioxide; Cholera; Diarrhea; Disease Models, Ani | 1970 |
Experimental diarrhea. I. Intestinal water and electrolyte transport in rat salmonella enterocolitis.
Topics: Animals; Bicarbonates; Biological Transport, Active; Colon; Diarrhea; Disease Models, Animal; Entero | 1971 |
Experimental diarrhea. 3. Bicarbonate transport in rat salmonella enterocolitis.
Topics: Acid-Base Equilibrium; Alkalosis; Animals; Bicarbonates; Biological Transport, Active; Carbon Dioxid | 1971 |