hydrogen carbonate has been researched along with Cystic Fibrosis in 182 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 9.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "To determine whether recombinant human growth hormone (rhGH), glutamine (GLN) or a combination of both agents can enhance protein synthesis in cystic fibrosis (CF) patients, six 9." | 7.71 | Can glutamine and growth hormone promote protein anabolism in children with cystic fibrosis? ( Darmaun, D; Hayes, V; Mauras, N; Punati, J; Schaeffer, D, 2002) |
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 5.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "To determine whether recombinant human growth hormone (rhGH), glutamine (GLN) or a combination of both agents can enhance protein synthesis in cystic fibrosis (CF) patients, six 9." | 3.71 | Can glutamine and growth hormone promote protein anabolism in children with cystic fibrosis? ( Darmaun, D; Hayes, V; Mauras, N; Punati, J; Schaeffer, D, 2002) |
| "Cystic fibrosis is a monogenic disease considered to affect at least 100 000 people worldwide." | 2.72 | Cystic fibrosis. ( Davies, JC; Haq, IJ; Polineni, D; Shteinberg, M, 2021) |
| "Cystic fibrosis (CF, mucoviscidosis) is caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), which is a chloride and bicarbonate channel necessary for fluid secretion and extracellular alkalization." | 2.55 | Bicarbonate in cystic fibrosis. ( Hadorn, HB; Kunzelmann, K; Schreiber, R, 2017) |
| "Furthermore, peptic ulcers are rare in cystic fibrosis (CF), although, with impaired HCO(3)(-) secretion, increased ulcer prevalence is predicted, giving rise to the 'CF Paradox'." | 2.41 | Duodenal intracellular bicarbonate and the 'CF paradox'. ( Akiba, Y; Kaunitz, JD, 2001) |
| "Metabolic alkalosis is defined as a primary increase in plasma bicarbonate concentration." | 2.38 | [Water-electrolyte and acid-base disorders. VII. Metabolic alkalosis]. ( Velásquez-Jones, L, 1990) |
| "Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are often associated with airway fluid acidification." | 1.72 | Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model. ( Csekő, K; Draskóczi, L; Hargitai, D; Helyes, Z; Jaikumpun, P; Kerémi, B; Kéri, A; Zsembery, Á, 2022) |
| "Cystic fibrosis is a genetic disease caused by mutation of the CFTR gene, which encodes a chloride and bicarbonate transporter in epithelial cells." | 1.72 | Complementary Dual Approach for In Silico Target Identification of Potential Pharmaceutical Compounds in Cystic Fibrosis. ( Hafkemeyer, S; Nietert, MM; Stanke, F; Vinhoven, L, 2022) |
| "Cystic fibrosis is a genetic disorder that results in a multi-organ disease with progressive respiratory decline which leads to premature death." | 1.62 | Mesenchymal Stem Cell exosome delivered Zinc Finger Protein activation of cystic fibrosis transmembrane conductance regulator. ( Grepo, N; Jaffe, A; Morris, KV; Scott, T; Villamizar, O; Waters, SA, 2021) |
| "Pretreatment with diminazene aceturate, a small molecule with ability to inhibit acid detection through blockade of the acid-sensing ion channel (ASIC) at the doses provided, did not prevent acid-induced pathologic mucus or transport defects but did mitigate airway obstruction." | 1.56 | Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways. ( Atanasova, KR; Bravo, L; Collins, EN; Dadural, JS; Eken, E; Guevara, MV; Kuan, SP; Liao, YSJ; Reznikov, LR; Schurmann, V; Sponchiado, M; Vogt, K, 2020) |
| "Dental caries is the single most prevalent and costly infectious disease worldwide, affecting more than 90% of the population in the U." | 1.37 | Elevated incidence of dental caries in a mouse model of cystic fibrosis. ( Bowen, WH; Catalán, MA; Klein, MI; Koo, H; Melvin, JE; Scott-Anne, K, 2011) |
| "Rosiglitazone has no effect on chloride secretion in the colon, but it increases expression of the genes encoding carbonic anhydrases 4 and 2 (Car4 and Car2), increases bicarbonate secretion and reduces mucus retention." | 1.36 | Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. ( Barrett, KE; Dennis, EA; Dong, H; Dumlao, DS; Glass, CK; Harmon, GS; Ng, DT, 2010) |
| " Results showed that a conventional powdered pancreatic extract (Pancrex V) required a high dosage to achieve reasonable improvement in fat and nitrogen absorption (200 mg/kg body weight/day on average) and rarely restored digestion to normal." | 1.27 | Influence of antacid and formulation on effectiveness of pancreatic enzyme supplementation in cystic fibrosis. ( Borgo, G; Braggion, C; Faggionato, P; Mastella, G, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (24.18) | 18.7374 |
| 1990's | 16 (8.79) | 18.2507 |
| 2000's | 47 (25.82) | 29.6817 |
| 2010's | 44 (24.18) | 24.3611 |
| 2020's | 31 (17.03) | 2.80 |
| Authors | Studies |
|---|---|
| Larsen, MB | 1 |
| Choi, JJ | 1 |
| Wang, X | 1 |
| Myerburg, MM | 1 |
| Frizzell, RA | 1 |
| Bertrand, CA | 1 |
| Bijvelds, MJC | 2 |
| Roos, FJM | 1 |
| Meijsen, KF | 1 |
| Roest, HP | 1 |
| Verstegen, MMA | 1 |
| Janssens, HM | 1 |
| van der Laan, LJW | 1 |
| de Jonge, HR | 3 |
| Ferrera, L | 2 |
| Cappiello, F | 1 |
| Loffredo, MR | 1 |
| Puglisi, E | 1 |
| Casciaro, B | 1 |
| Botta, B | 1 |
| Galietta, LJV | 2 |
| Mori, M | 1 |
| Mangoni, ML | 1 |
| Angyal, D | 1 |
| Bruno, MJ | 1 |
| Peppelenbosch, MP | 1 |
| Berg, P | 3 |
| Andersen, JF | 1 |
| Sørensen, MV | 1 |
| Wang, T | 1 |
| Malte, H | 1 |
| Leipziger, J | 3 |
| Pankonien, I | 1 |
| Quaresma, MC | 1 |
| Rodrigues, CS | 1 |
| Amaral, MD | 1 |
| Csekő, K | 1 |
| Hargitai, D | 1 |
| Draskóczi, L | 1 |
| Kéri, A | 1 |
| Jaikumpun, P | 2 |
| Kerémi, B | 1 |
| Helyes, Z | 1 |
| Zsembery, Á | 3 |
| Mathiaparanam, S | 1 |
| de Macedo, AN | 1 |
| Gill, B | 1 |
| Keenan, K | 1 |
| Gonska, T | 1 |
| Pedder, L | 1 |
| Hill, S | 1 |
| Britz-McKibbin, P | 1 |
| Saint-Criq, V | 2 |
| Guequén, A | 1 |
| Philp, AR | 1 |
| Villanueva, S | 1 |
| Apablaza, T | 1 |
| Fernández-Moncada, I | 1 |
| Mansilla, A | 1 |
| Delpiano, L | 1 |
| Ruminot, I | 1 |
| Carrasco, C | 1 |
| Gray, MA | 7 |
| Flores, CA | 1 |
| Ash, JJ | 1 |
| Hilkin, BM | 1 |
| Gansemer, ND | 1 |
| Hoffman, EA | 1 |
| Zabner, J | 6 |
| Stoltz, DA | 8 |
| Abou Alaiwa, MH | 4 |
| Ozsin-Ozler, C | 1 |
| Duruel, O | 1 |
| Pinar, A | 1 |
| Özbek, B | 1 |
| Yaz, İ | 1 |
| Ataman-Duruel, ET | 1 |
| Uzamis-Tekcicek, M | 1 |
| Gunes-Yalcın, E | 1 |
| Dogru-Ersoz, D | 1 |
| Kiper, N | 1 |
| Tezcan, İ | 1 |
| Berker, E | 1 |
| Ludovico, A | 2 |
| Moran, O | 4 |
| Baroni, D | 3 |
| Berke, G | 1 |
| Gede, N | 1 |
| Szadai, L | 1 |
| Ocskay, K | 1 |
| Hegyi, P | 2 |
| Sahin-Tóth, M | 1 |
| Hegyi, E | 1 |
| Scull, CE | 1 |
| Luo, M | 1 |
| Jennings, S | 1 |
| Taylor, CM | 1 |
| Wang, G | 1 |
| Vinhoven, L | 1 |
| Stanke, F | 1 |
| Hafkemeyer, S | 1 |
| Nietert, MM | 1 |
| Sorensen, MV | 1 |
| Rousing, AQ | 1 |
| Vebert Olesen, H | 1 |
| Jensen-Fangel, S | 1 |
| Jeppesen, M | 2 |
| Patel, D | 1 |
| Mathews, S | 1 |
| van Unen, V | 1 |
| Chan, JE | 1 |
| Al-Hammadi, N | 1 |
| Borowitz, D | 3 |
| Gelfond, D | 1 |
| Sellers, ZM | 3 |
| Liao, YSJ | 2 |
| Kuan, SP | 1 |
| Guevara, MV | 2 |
| Collins, EN | 2 |
| Atanasova, KR | 2 |
| Dadural, JS | 1 |
| Vogt, K | 1 |
| Schurmann, V | 2 |
| Bravo, L | 2 |
| Eken, E | 1 |
| Sponchiado, M | 2 |
| Reznikov, LR | 2 |
| Adewale, AT | 1 |
| Falk Libby, E | 1 |
| Fu, L | 1 |
| Lenzie, A | 1 |
| Boitet, ER | 1 |
| Birket, SE | 2 |
| Petty, CF | 1 |
| Johns, JD | 1 |
| Mazur, M | 1 |
| Tearney, GJ | 2 |
| Copeland, D | 1 |
| Durham, C | 1 |
| Rowe, SM | 2 |
| Fiore, M | 2 |
| Picco, C | 2 |
| Hoegger, MJ | 3 |
| Ruksakiet, K | 1 |
| Stercz, B | 1 |
| Pállinger, É | 1 |
| Steward, M | 1 |
| Lohinai, Z | 1 |
| Dobay, O | 1 |
| Parker, MD | 1 |
| Villamizar, O | 1 |
| Waters, SA | 1 |
| Scott, T | 1 |
| Grepo, N | 1 |
| Jaffe, A | 1 |
| Morris, KV | 1 |
| Kim, D | 1 |
| Liao, J | 2 |
| Scales, NB | 1 |
| Martini, C | 1 |
| Luan, X | 1 |
| Abu-Arish, A | 1 |
| Robert, R | 1 |
| Luo, Y | 1 |
| McKay, GA | 1 |
| Nguyen, D | 1 |
| Tewfik, MA | 1 |
| Poirier, CD | 1 |
| Matouk, E | 1 |
| Ianowski, JP | 1 |
| Frenkiel, S | 1 |
| Hanrahan, JW | 1 |
| Li, X | 2 |
| Villacreses, R | 1 |
| Thornell, IM | 3 |
| Noriega, J | 1 |
| Mather, S | 1 |
| Brommel, CM | 1 |
| Lu, L | 1 |
| Zabner, A | 1 |
| Ehler, A | 1 |
| Meyerholz, DK | 3 |
| Giorgetti, M | 1 |
| Klymiuk, N | 1 |
| Bähr, A | 1 |
| Hemmerling, M | 1 |
| Jinton, L | 1 |
| Tarran, R | 1 |
| Malmgren, A | 1 |
| Åstrand, A | 1 |
| Hansson, GC | 3 |
| Ermund, A | 3 |
| Shteinberg, M | 1 |
| Haq, IJ | 2 |
| Polineni, D | 1 |
| Davies, JC | 1 |
| Rehman, T | 1 |
| Karp, PH | 7 |
| Tan, P | 1 |
| Goodell, BJ | 1 |
| Pezzulo, AA | 2 |
| Thurman, AL | 1 |
| Durfey, SL | 1 |
| Duffey, ME | 1 |
| McKone, EF | 2 |
| Singh, PK | 2 |
| Welsh, MJ | 9 |
| Morrison, CB | 1 |
| Shaffer, KM | 1 |
| Araba, KC | 1 |
| Markovetz, MR | 1 |
| Wykoff, JA | 1 |
| Quinney, NL | 1 |
| Hao, S | 1 |
| Delion, MF | 1 |
| Flen, AL | 1 |
| Morton, LC | 1 |
| Hill, DB | 1 |
| Drumm, ML | 1 |
| O'Neal, WK | 2 |
| Kesimer, M | 1 |
| Gentzsch, M | 1 |
| Ehre, C | 1 |
| Kunzelmann, K | 1 |
| Schreiber, R | 1 |
| Hadorn, HB | 1 |
| Illek, B | 3 |
| Figueira, MF | 1 |
| Hari, G | 1 |
| Joo, NS | 2 |
| Sibley, E | 1 |
| Souza-Menezes, J | 1 |
| Morales, MM | 1 |
| Fischer, H | 3 |
| Wine, JJ | 4 |
| Davis, JM | 1 |
| Fernandez, CM | 1 |
| Tuggle, KL | 1 |
| Oden, AM | 1 |
| Chu, KK | 1 |
| Fanucchi, MV | 1 |
| Sorscher, EJ | 1 |
| Varasteh Kia, M | 1 |
| Barone, S | 1 |
| McDonough, AA | 1 |
| Zahedi, K | 1 |
| Xu, J | 1 |
| Soleimani, M | 7 |
| Rubenstein, RC | 1 |
| Launspach, JL | 1 |
| Grogan, B | 1 |
| Carter, S | 1 |
| Button, B | 1 |
| Goodell, HP | 1 |
| Atieh, E | 1 |
| Chen, YC | 1 |
| Williams, R | 1 |
| Shenoy, S | 1 |
| Lackey, E | 1 |
| Shenkute, NT | 1 |
| Cai, LH | 1 |
| Dennis, RG | 1 |
| Boucher, RC | 3 |
| Rubinstein, M | 1 |
| Cossu, C | 1 |
| Capurro, V | 1 |
| Mielczarek, M | 1 |
| Carreira-Barral, I | 1 |
| Caci, E | 1 |
| Quesada, R | 1 |
| Muraglia, KA | 1 |
| Chorghade, RS | 1 |
| Kim, BR | 1 |
| Tang, XX | 6 |
| Shah, VS | 3 |
| Grillo, AS | 1 |
| Daniels, PN | 1 |
| Cioffi, AG | 1 |
| Zhu, L | 1 |
| Burke, MD | 1 |
| Simonin, J | 1 |
| Bille, E | 1 |
| Crambert, G | 1 |
| Noel, S | 1 |
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| Edwards, A | 1 |
| Hatton, A | 1 |
| Pranke, I | 1 |
| Villeret, B | 1 |
| Cottart, CH | 1 |
| Vrel, JP | 1 |
| Urbach, V | 1 |
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| Jung, J | 1 |
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| Lewis, MD | 2 |
| Park, HW | 2 |
| Brand, RE | 2 |
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| Abou Alaiwa, M | 1 |
| Ernst, SE | 1 |
| Wohlford-Lenane, CL | 2 |
| Heilmann, KP | 1 |
| Leidinger, MR | 1 |
| Allen, PD | 1 |
| McCray, PB | 2 |
| Randak, CO | 1 |
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| Parker, CP | 1 |
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| Galietta, LJ | 1 |
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| van Eijk, M | 1 |
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| Schaeffer, D | 1 |
| Mauras, N | 1 |
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| Shcheynikov, N | 3 |
| Choi, JY | 2 |
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| Ishibashi, K | 1 |
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| Ho, LS | 1 |
| Lo, PS | 1 |
| Liu, Y | 1 |
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| Chung, YW | 1 |
| Sutton, KA | 1 |
| Jungnickel, MK | 1 |
| Florman, HM | 1 |
| Martinu, T | 1 |
| Menzies, D | 1 |
| Dial, S | 1 |
| Grubb, BR | 2 |
| Gatzy, JT | 1 |
| Johnson, LG | 1 |
| Kreda, SM | 1 |
| Zeng, W | 2 |
| Dorwart, MR | 2 |
| Millen, L | 1 |
| Goto, H | 1 |
| Soyombo, A | 1 |
| Hirokawa, M | 1 |
| Takeuchi, T | 1 |
| Chu, S | 1 |
| Wu, V | 1 |
| Guth, PH | 1 |
| Engel, E | 1 |
| Montrose, MH | 1 |
| Childs, D | 1 |
| Chow, JY | 1 |
| Smith, AJ | 1 |
| Hogan, DL | 3 |
| Isenberg, JI | 3 |
| Pratha, VS | 2 |
| Simpson, JE | 1 |
| Gawenis, LR | 2 |
| Walker, NM | 3 |
| Boyle, KT | 1 |
| Clarke, LL | 4 |
| Salinas, D | 1 |
| Nielson, DW | 1 |
| Verkman, AS | 3 |
| Wang, Z | 1 |
| Colledge, WH | 2 |
| Kalnins, D | 1 |
| Ellis, L | 1 |
| Corey, M | 4 |
| Pencharz, PB | 1 |
| Stewart, C | 1 |
| Tullis, E | 1 |
| Durie, PR | 3 |
| Wang, Y | 2 |
| Soyombo, AA | 1 |
| Dorwart, M | 1 |
| Marino, CR | 1 |
| Stippec, S | 1 |
| Morton, D | 1 |
| Parker, A | 1 |
| Estrada, P | 1 |
| Martinez, JR | 1 |
| Shiffman, ML | 2 |
| Gillon, MJ | 1 |
| Galey, WR | 2 |
| Adelson, JW | 1 |
| Anderson, CM | 4 |
| Applegarth, DA | 1 |
| Davidson, AG | 2 |
| Sorenson, P | 1 |
| Wong, LT | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cystic Fibrosis in the Kidney: Monitoring the Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in Urine After a Short Pause of Therapy[NCT05818319] | 30 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| Development a Core Set for Adults With Cystic Fibrosis Based on the International Classification of Functioning, Disability, and Health (ICF)[NCT06128499] | 30 participants (Anticipated) | Observational | 2023-12-20 | Not yet recruiting | |||
| Symptom Based Performance of Airway Clearance Therapy After Starting Highly Effective CFTR Modulator Therapy for Cystic Fibrosis[NCT05392855] | 30 participants (Anticipated) | Interventional | 2023-09-05 | Recruiting | |||
| Phase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CF[NCT00406536] | Phase 2 | 110 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
34 reviews available for hydrogen carbonate and Cystic Fibrosis
| Article | Year |
|---|---|
Bicarbonate Transport in Cystic Fibrosis and Pancreatitis.
Topics: Animals; Bicarbonates; Biological Transport; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conducta | 2021 |
CFTR, Cell Junctions and the Cytoskeleton.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytos | 2022 |
Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Human | 2022 |
Cystic fibrosis in the kidney: new lessons from impaired renal HCO3- excretion.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; | 2021 |
Cystic fibrosis.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disea | 2021 |
Bicarbonate in cystic fibrosis.
Topics: Bicarbonates; Chloride-Bicarbonate Antiporters; Cystic Fibrosis; Cystic Fibrosis Transmembrane Condu | 2017 |
The cystic fibrosis of exocrine pancreas.
Topics: Animals; Bicarbonates; Chloride Channels; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2013 |
The cystic fibrosis intestine.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease | 2013 |
CFTR, bicarbonate, and the pathophysiology of cystic fibrosis.
Topics: Animals; Bicarbonates; Body Fluids; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduc | 2015 |
The Physiology and Pathophysiology of Pancreatic Ductal Secretion: The Background for Clinicians.
Topics: Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Pancreas | 2015 |
Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets.
Topics: Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Manageme | 2016 |
CFTR pharmacology.
Topics: Animals; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulat | 2017 |
Role of CFTR in epithelial physiology.
Topics: Animals; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulat | 2017 |
Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis.
Topics: Bicarbonates; Cystic Fibrosis; Humans; Mucins; Mucus; Pancreas | 2008 |
Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension.
Topics: Animals; Bicarbonates; Biological Transport; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conducta | 2009 |
Purinergic regulation of duodenal surface pH and ATP concentration: implications for mucosal defence, lipid uptake and cystic fibrosis.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduc | 2011 |
Role of epithelial HCO3⁻ transport in mucin secretion: lessons from cystic fibrosis.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; | 2010 |
Physiology and pathophysiology of bicarbonate secretion by pancreatic duct epithelium.
Topics: Animals; Bicarbonates; Biological Transport, Active; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 2012 |
Mechanisms of bicarbonate secretion: lessons from the airways.
Topics: Benzimidazoles; Bicarbonates; Bronchi; Calcium; Calcium Channel Agonists; Calcium Channels; Cell Lin | 2012 |
Too much salt, too little soda: cystic fibrosis.
Topics: Anions; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; | 2007 |
Pathophysiology of the pancreas in cystic fibrosis.
Topics: Animals; Bicarbonates; Biological Transport; Chlorides; Cystic Fibrosis; Exocrine Pancreatic Insuffi | 1984 |
Chloride channels and cystic fibrosis of the pancreas.
Topics: Animals; Bicarbonates; Chloride Channels; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 1995 |
Genetic disorders of membrane transport. II. Regulation of CFTR by small molecules including HCO3-.
Topics: Bicarbonates; Chloride Channels; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulato | 1998 |
Bicarbonate secretion and CFTR: continuing the paradigm shift.
Topics: Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans | 2000 |
How cystic fibrosis affects pancreatic ductal bicarbonate secretion.
Topics: Acid-Base Equilibrium; Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduct | 2000 |
Pharmacological treatment of the ion transport defect in cystic fibrosis.
Topics: Amiloride; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Genis | 2001 |
150 mM HCO3(-)--how does the pancreas do it? Clues from computer modelling of the duct cell.
Topics: Animals; Bicarbonates; Computer Simulation; Cystic Fibrosis; Humans; Models, Biological; Pancreatic | 2001 |
Selective activation of cystic fibrosis transmembrane conductance regulator Cl- and HCO3- conductances.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epith | 2001 |
Bicarbonate secretion in the murine gallbladder--lessons for the treatment of cystic fibrosis.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease | 2001 |
Duodenal intracellular bicarbonate and the 'CF paradox'.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Duodenal Ulcer; Duodenum; Humans; Hydrogen-Ion Concentration | 2001 |
HCO3- transport in relation to mucus secretion from submucosal glands.
Topics: Animals; Bicarbonates; Biological Transport, Active; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 2001 |
Relationship between bile acid malabsorption and pancreatic insufficiency in cystic fibrosis.
Topics: Adolescent; Adult; Bicarbonates; Bile Acids and Salts; Child; Child, Preschool; Cystic Fibrosis; Fec | 1976 |
[Water-electrolyte and acid-base disorders. VII. Metabolic alkalosis].
Topics: Alkalosis; Bartter Syndrome; Bicarbonates; Chlorides; Cystic Fibrosis; Diuretics; Gastrointestinal D | 1990 |
Current concepts: pancreatic extracts.
Topics: Adolescent; Adult; Animals; Bicarbonates; Cattle; Celiac Disease; Child; Cystic Fibrosis; Dietary Fa | 1969 |
2 trials available for hydrogen carbonate and Cystic Fibrosis
| Article | Year |
|---|---|
Enteric-coated pancreatic enzyme with bicarbonate is equal to standard enteric-coated enzyme in treating malabsorption in cystic fibrosis.
Topics: Adolescent; Adult; Bicarbonates; Child; Cross-Over Studies; Cystic Fibrosis; Double-Blind Method; Ex | 2006 |
Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.
Topics: Adolescent; Bicarbonates; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Dietary Fats; Drug The | 1980 |
146 other studies available for hydrogen carbonate and Cystic Fibrosis
| Article | Year |
|---|---|
Separating the contributions of SLC26A9 and CFTR to anion secretion in primary human bronchial epithelia.
Topics: Antiporters; Bicarbonates; Biological Transport; Bronchi; Cells, Cultured; Chlorides; Cystic Fibrosi | 2021 |
Rescue of chloride and bicarbonate transport by elexacaftor-ivacaftor-tezacaftor in organoid-derived CF intestinal and cholangiocyte monolayers.
Topics: Aminophenols; Benzodioxoles; Bicarbonates; Chloride Channel Agonists; Chloride-Bicarbonate Antiporte | 2022 |
Esc peptides as novel potentiators of defective cystic fibrosis transmembrane conductance regulator: an unprecedented property of antimicrobial peptides.
Topics: Animals; Anti-Bacterial Agents; Antimicrobial Peptides; Bicarbonates; Chlorides; Cystic Fibrosis; Cy | 2021 |
Alkalosis-induced hypoventilation in cystic fibrosis: The importance of efficient renal adaptation.
Topics: Acid-Base Equilibrium; Alkalosis; Animals; Bicarbonates; Chloride-Bicarbonate Antiporters; Cystic Fi | 2022 |
Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model.
Topics: Animals; Bicarbonates; Cigarette Smoking; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2022 |
Rapid chloride and bicarbonate determination by capillary electrophoresis for confirmatory testing of cystic fibrosis infants with volume-limited sweat specimens.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Electrophoresis, Capillary; Humans; Infant; Infant, Newbor | 2023 |
Inhibition of the sodium-dependent HCO
Topics: Animals; Anion Exchange Protein 1, Erythrocyte; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fib | 2022 |
Tromethamine improves mucociliary clearance in cystic fibrosis pigs.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Mucociliary Clearance; Respiratory Mucosa; Swine; Tromethami | 2022 |
Dental caries and associated salivary biomarkers in patients with cystic fibrosis.
Topics: Adolescent; alpha-Defensins; beta-Defensins; Bicarbonates; Biomarkers; Calcium; Child; Chlorides; Cr | 2022 |
Modulator Combination Improves In Vitro the Microrheological Properties of the Airway Surface Liquid of Cystic Fibrosis Airway Epithelia.
Topics: Aminophenols; Benzodioxoles; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 2022 |
Cftr deletion in mouse epithelial and immune cells differentially influence the intestinal microbiota.
Topics: Animals; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulat | 2022 |
Complementary Dual Approach for In Silico Target Identification of Potential Pharmaceutical Compounds in Cystic Fibrosis.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Human | 2022 |
Challenged Urine Bicarbonate Excretion as a Measure of Cystic Fibrosis Transmembrane Conductance Regulator Function in Cystic Fibrosis.
Topics: Adult; Bicarbonates; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Condu | 2022 |
Impaired distal colonic pH in adults with cystic fibrosis.
Topics: Adult; Bicarbonates; Colon; Cystic Fibrosis; Gastrointestinal Motility; Humans; Hydrogen-Ion Concent | 2023 |
Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Airway Obstruction; Anima | 2020 |
Novel Therapy of Bicarbonate, Glutathione, and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport.
Topics: Ascorbic Acid; Bicarbonates; Cells, Cultured; Cystic Fibrosis; Epithelial Cells; Glutathione; Humans | 2020 |
Correctors modify the bicarbonate permeability of F508del-CFTR.
Topics: Aminopyridines; Animals; Benzodioxoles; Bicarbonates; Cell Membrane; Cell Membrane Permeability; Cel | 2020 |
Airway cholinergic history modifies mucus secretion properties to subsequent cholinergic challenge in diminished chloride and bicarbonate conditions.
Topics: Airway Resistance; Animals; Bethanechol; Bicarbonates; Biological Transport; Chlorides; Cholinergic | 2020 |
Antibacterial Effects of Bicarbonate in Media Modified to Mimic Cystic Fibrosis Sputum.
Topics: Anti-Bacterial Agents; Bicarbonates; Culture Media; Cystic Fibrosis; Humans; Pseudomonas aeruginosa; | 2020 |
Soda stream modifies airway fluid.
Topics: Bicarbonates; Cystic Fibrosis; Humans; Hydrogen-Ion Concentration; Respiratory System; Rivers | 2020 |
Mesenchymal Stem Cell exosome delivered Zinc Finger Protein activation of cystic fibrosis transmembrane conductance regulator.
Topics: Bicarbonates; Cell Membrane; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance R | 2021 |
Large pH oscillations promote host defense against human airways infection.
Topics: Adult; Bicarbonates; Bronchi; Carbonic Anhydrases; Case-Control Studies; Cells, Cultured; Cystic Fib | 2021 |
V-Type ATPase Mediates Airway Surface Liquid Acidification in Pig Small Airway Epithelial Cells.
Topics: Animals; Animals, Genetically Modified; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 2021 |
New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition.
Topics: Animals; Animals, Newborn; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2021 |
Inflammatory cytokines TNF-α and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators.
Topics: Aminophenols; Benzodioxoles; Bicarbonates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transme | 2021 |
Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties
Topics: Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Ion Tran | 2022 |
Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease.
Topics: Animals; Bicarbonates; Bronchi; Cells, Cultured; Chlorides; Cystic Fibrosis; Dinoprostone; Humans; I | 2017 |
Development of an airway mucus defect in the cystic fibrosis rat.
Topics: Animals; Bicarbonates; Biological Transport; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conducta | 2018 |
Downregulation of the Cl-/HCO3-Exchanger Pendrin in Kidneys of Mice with Cystic Fibrosis: Role in the Pathogenesis of Metabolic Alkalosis.
Topics: Alkalosis; Animals; Anion Transport Proteins; Bicarbonates; Blood Gas Analysis; Chlorides; Cystic Fi | 2018 |
Editorial Focus: CFTR-dependent bicarbonate secretion by Calu-3 cells.
Topics: Bicarbonates; Cell Line, Tumor; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator | 2018 |
Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis.
Topics: Adult; Aminophenols; Animals; Bicarbonates; Biological Transport, Active; Bronchoalveolar Lavage Flu | 2018 |
Roles of mucus adhesion and cohesion in cough clearance.
Topics: Bicarbonates; Cell Adhesion; Cough; Cystic Fibrosis; Epithelial Cells; Humans; Hydrogen-Ion Concentr | 2018 |
Lumacaftor-rescued F508del-CFTR has a modified bicarbonate permeability.
Topics: Aminopyridines; Anion Transport Proteins; Benzodioxoles; Bicarbonates; Cell Membrane Permeability; C | 2019 |
Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis.
Topics: Animals; Bicarbonates; Cell Line; Cell Survival; Chlorides; Cricetulus; Cystic Fibrosis; Cystic Fibr | 2019 |
Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia.
Topics: Amphotericin B; Animals; Bicarbonates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembra | 2019 |
Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis.
Topics: Antimicrobial Cationic Peptides; Bicarbonates; Bronchi; Cathelicidins; Cell Line; Cells, Cultured; C | 2019 |
Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport.
Topics: Animals; Anion Transport Proteins; Aquaporin 5; Bicarbonates; Biological Transport; Brunner Glands; | 2013 |
Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO3(-) transport and reduces survival in CFTR-deficient mice.
Topics: Animals; Antiporters; Bicarbonates; Cell Proliferation; Cystic Fibrosis; Cystic Fibrosis Transmembra | 2015 |
Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis.
Topics: Bicarbonates; Cell Membrane Permeability; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 2014 |
Chemical rescue of ΔF508-CFTR in C127 epithelial cells reverses aberrant extracellular pH acidification to wild-type alkalization as monitored by microphysiometry.
Topics: Animals; Bicarbonates; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulat | 2014 |
Composition of mineralizing incisor enamel in cystic fibrosis transmembrane conductance regulator-deficient mice.
Topics: Ameloblasts; Amelogenesis; Animals; Bicarbonates; Buffers; Calcium; Cariostatic Agents; Chlorides; C | 2015 |
Diagnostic accuracy of secretin-stimulated ultrasonography of the pancreas assessing exocrine pancreatic failure in cystic fibrosis and chronic pancreatitis.
Topics: Adolescent; Adult; Aged; Bicarbonates; Case-Control Studies; Cystic Fibrosis; Duodenum; Exocrine Pan | 2015 |
Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus.
Topics: Animals; Bicarbonates; Calcium Chelating Agents; Cystic Fibrosis; Cystic Fibrosis Transmembrane Cond | 2015 |
Diagnostic Accuracy of a Short Endoscopic Secretin Test in Patients With Cystic Fibrosis.
Topics: Adolescent; Adult; Aged; Bicarbonates; Cystic Fibrosis; Duodenum; Endoscopy; Exocrine Pancreatic Ins | 2015 |
Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense.
Topics: Alveolar Epithelial Cells; Animals; Bicarbonates; Biological Transport; Cells, Cultured; Cystic Fibr | 2016 |
Acidic pH increases airway surface liquid viscosity in cystic fibrosis.
Topics: Alveolar Epithelial Cells; Animals; Bicarbonates; Carbohydrate Sequence; Cells, Cultured; Cystic Fib | 2016 |
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
Topics: Acids; Animals; Bicarbonates; Cystic Fibrosis; H(+)-K(+)-Exchanging ATPase; Humans; Hydrogen-Ion Con | 2016 |
Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies.
Topics: Animals; Animals, Newborn; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2016 |
Mechanism of direct bicarbonate transport by the CFTR anion channel.
Topics: Animals; Bicarbonates; Chlorides; Cricetinae; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduct | 2009 |
Pass the bicarb: the importance of HCO3- for mucin release.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Exocyto | 2009 |
Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicarbonates; Bumetanide; Cystic Fibrosis | 2009 |
Birth of mucus.
Topics: Animals; Bicarbonates; Biological Transport; Calcium; Cystic Fibrosis; Fetus; Humans; Mucins; Mucus | 2010 |
Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice.
Topics: Animals; Bicarbonates; Carbonic Anhydrase II; Carbonic Anhydrase IV; Colon; Cystic Fibrosis; Cystic | 2010 |
Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Bicarbonates; Cilia; Cyclic AMP; Cystic Fibrosis; Cy | 2010 |
Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Base Sequence; Bicarbonates; Carrier Proteins; Child; Ch | 2011 |
Elevated incidence of dental caries in a mouse model of cystic fibrosis.
Topics: Animals; Bicarbonates; Carbohydrate Metabolism; Cystic Fibrosis; Dental Caries; Disease Models, Anim | 2011 |
Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia.
Topics: Adenylyl Cyclases; Adult; Animals; Azoospermia; Bicarbonates; Blotting, Western; Cyclic AMP; Cyclic | 2011 |
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Re | 2012 |
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.
Topics: Animals; Animals, Newborn; Anti-Infective Agents; Bicarbonates; Body Fluids; Cystic Fibrosis; Cystic | 2012 |
Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct.
Topics: Animals; Antiporters; Bicarbonates; Chlorides; Cystic Fibrosis; Disease Models, Animal; Gene Deletio | 2012 |
Transepithelial bicarbonate secretion: lessons from the pancreas.
Topics: Bicarbonates; Biological Transport; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regul | 2012 |
Oxidant stress stimulates anion secretion from the human airway epithelial cell line Calu-3: implications for cystic fibrosis lung disease.
Topics: Anions; Bicarbonates; Cell Line; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductan | 2002 |
Targeting of carbonic anhydrase IV to plasma membranes is altered in cultured human pancreatic duct cells expressing a mutated (deltaF508) CFTR.
Topics: Actins; Adult; Bicarbonates; Carbonic Anhydrase IV; Carcinoma; Cell Division; Cell Membrane; Cell Po | 2002 |
Can glutamine and growth hormone promote protein anabolism in children with cystic fibrosis?
Topics: Bicarbonates; Carbon Isotopes; Child; Cystic Fibrosis; Female; Glutamine; Human Growth Hormone; Huma | 2002 |
A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibros | 2002 |
Polarized distribution of HCO3- transport in human normal and cystic fibrosis nasal epithelia.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adult; Amiloride; Barium; Bicarbonates; Biological | 2003 |
Disruptive effects of anion secretion inhibitors on airway mucus morphology in isolated perfused pig lung.
Topics: Adrenergic beta-Agonists; Algorithms; Amiloride; Animals; Anions; Bethanechol; Bicarbonates; Bronchi | 2003 |
Rules of conduct for the cystic fibrosis anion channel.
Topics: Adenosine Triphosphate; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Cond | 2003 |
Abnormal passive chloride absorption in cystic fibrosis jejunum functionally opposes the classic chloride secretory defect.
Topics: Adult; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator | 2003 |
[STUDY OF THE EXOCRINE FUNCTION OF THE PANCREAS WITH SECRETIN AND PANCREOZYMIN].
Topics: Amylases; Bicarbonates; Cholecystokinin; Cystic Fibrosis; Diarrhea; Gastrointestinal Hormones; Hemoc | 1963 |
[STUDY OF THE EXOCRINE FUNCTION OF THE PANCREAS WITH SECRETIN AND PANCREOZYMIN].
Topics: Amylases; Bicarbonates; Cholecystokinin; Cystic Fibrosis; Diarrhea; Gastrointestinal Hormones; Hemoc | 1963 |
Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm.
Topics: Animals; Bicarbonates; Cells, Cultured; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Tran | 2003 |
Of fertility, cystic fibrosis and the bicarbonate ion.
Topics: Bicarbonates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Fertiliz | 2003 |
Re-evaluation of acid-base prediction rules in patients with chronic respiratory acidosis.
Topics: Acid-Base Imbalance; Acidosis, Respiratory; Adaptation, Physiological; Adult; Aged; Bicarbonates; Bl | 2003 |
Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium.
Topics: Bicarbonates; Bronchi; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Ex | 2003 |
Gating of CFTR by the STAS domain of SLC26 transporters.
Topics: Antiporters; Bicarbonates; Carrier Proteins; Cell Line; Cell Membrane; Chloride-Bicarbonate Antiport | 2004 |
Bicarbonate secretion: it takes two to tango.
Topics: Animals; Antiporters; Bicarbonates; Carrier Proteins; Cell Membrane; Chloride-Bicarbonate Antiporter | 2004 |
Cystic fibrosis gene mutation reduces epithelial cell acidification and injury in acid-perfused mouse duodenum.
Topics: Animals; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulat | 2004 |
Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway.
Topics: Animals; Bacterial Toxins; Benzoquinones; Bicarbonates; Cell Membrane; Chloride-Bicarbonate Antiport | 2005 |
Chloride conductance of CFTR facilitates basal Cl-/HCO3- exchange in the villous epithelium of intact murine duodenum.
Topics: Animals; Antiporters; Bicarbonates; Chlorine; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduct | 2005 |
Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis.
Topics: Adolescent; Adult; Animals; Bicarbonates; Body Fluids; Child; Child, Preschool; Cystic Fibrosis; Cys | 2006 |
Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion.
Topics: Animals; Antiporters; Bicarbonates; Carbachol; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmemb | 2006 |
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis.
Topics: Animals; Antiporters; Bicarbonates; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduc | 2006 |
SLC26A9 is a Cl(-) channel regulated by the WNK kinases.
Topics: Animals; Antiporters; Bicarbonates; Cell Line; Chlorides; Cystic Fibrosis; Epithelial Cells; Female; | 2007 |
Exocrine pancreatic secretion in rats treated with reserpine after stimulation with pilocarpine, dopamine, and caerulein.
Topics: Amylases; Animals; Bicarbonates; Ceruletide; Chlorides; Cystic Fibrosis; Disease Models, Animal; Dop | 1980 |
Pancreatic function in the reserpinized rabbit--a model for cystic fibrosis. I. Effect of secretin.
Topics: Amylases; Animals; Bicarbonates; Calcium; Cystic Fibrosis; Male; Pancreatic Juice; Proteins; Rabbits | 1982 |
Hypothesis revisited: cystic fibrosis: a disturbance of water and electrolyte movement in exocrine secretory tissue associated with altered prostaglandin (PGE2) metabolism?
Topics: Bicarbonates; Body Water; Cell Membrane Permeability; Chlorides; Cystic Fibrosis; Dinoprostone; Exoc | 1984 |
Abnormal anion exchange mechanism operates in the sweat glands of cystic fibrosis patients.
Topics: Adolescent; Bicarbonates; Child; Chlorides; Cystic Fibrosis; Female; Humans; Male; Pancreatic Juice; | 1984 |
Altered bicarbonate reabsorption in the pancreas of reserpine-treated rabbits--a model for cystic fibrosis.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Disease Models, Animal; Male; Pancreatic Juice; Rabbits; Res | 1983 |
Secretin pancreozymin stimulation test and confirmation of the diagnosis of cystic fibrosis.
Topics: Adolescent; Adult; Bicarbonates; Child; Child, Preschool; Cholecystokinin; Cystic Fibrosis; Female; | 1982 |
Evidence for a primary defect of pancreatic HCO3-secretion in cystic fibrosis.
Topics: Adolescent; Adult; Bicarbonates; Body Water; Child; Child, Preschool; Cystic Fibrosis; Humans; Infan | 1982 |
Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.
Topics: 3T3 Cells; Animals; Bicarbonates; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conducta | 1994 |
Ion transport across the jejunum in normal and cystic fibrosis mice.
Topics: Animals; Bicarbonates; Bumetanide; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Electric Condu | 1995 |
Evidence against defective trans-Golgi acidification in cystic fibrosis.
Topics: 3T3 Cells; Animals; Bicarbonates; Cattle; Cell Compartmentation; Cells, Cultured; Chloride Channels; | 1996 |
CFTR is required for cAMP inhibition of intestinal Na+ absorption in a cystic fibrosis mouse model.
Topics: Animals; Bicarbonates; Bumetanide; Calcium; Calcium Channel Blockers; Chlorides; Cyclic AMP; Cystic | 1996 |
In vivo measurement of chloride and water secretion in the jejunum of cystic fibrosis patients.
Topics: Adolescent; Adult; Bicarbonates; Body Water; Catheterization; Chlorides; Cystic Fibrosis; Electrophy | 1996 |
Angiotensin II receptor type I-regulated anion secretion in cystic fibrosis pancreatic duct cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Angiotensin II; Angiotensin Receptor Antagonists; | 1997 |
Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice.
Topics: Animals; Bicarbonates; Biological Transport, Active; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 1997 |
Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus.
Topics: Acetylcholine; Animals; Bicarbonates; Bronchi; Chemical Phenomena; Chemistry, Physical; Chlorides; C | 1998 |
Restoration by intratracheal gene transfer of bicarbonate secretion in cystic fibrosis mouse gallbladder.
Topics: Animals; beta-Galactosidase; Bicarbonates; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis T | 1998 |
CFTR drives Na+-nHCO-3 cotransport in pancreatic duct cells: a basis for defective HCO-3 secretion in CF.
Topics: Amino Acid Sequence; Bicarbonates; Carrier Proteins; Cell Line; Cell Membrane; Cyclic AMP; Cystic Fi | 1999 |
Formal analysis of electrogenic sodium, potassium, chloride and bicarbonate transport in mouse colon epithelium.
Topics: Acetazolamide; Amiloride; Animals; Bicarbonates; Biological Transport; Chlorides; Colforsin; Colon; | 1999 |
Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis.
Topics: Acid-Base Equilibrium; Acids; Adult; Alkalies; Ammonium Chloride; Antiporters; Bacterial Toxins; Bic | 2000 |
Cystic fibrosis transmembrane conductance regulator currents in guinea pig pancreatic duct cells: inhibition by bicarbonate ions.
Topics: Animals; Anions; Bicarbonates; Carbon Dioxide; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; | 2000 |
Extracellular UTP stimulates electrogenic bicarbonate secretion across CFTR knockout gallbladder epithelium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Age Factors; Animals; Bicarbonates; Biological Tra | 2000 |
Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis.
Topics: Bicarbonates; Biological Transport; Cell Line; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmemb | 2001 |
Gastric secretion in cystic fibrosis in relation to the migrating motor complex.
Topics: Adult; Aged; Bicarbonates; Bilirubin; Cystic Fibrosis; Female; Gastric Acid; Gastric Juice; Gastroin | 2001 |
Cystic fibrosis: the 'bicarbonate before chloride' hypothesis.
Topics: Bicarbonates; Biological Transport; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduc | 2001 |
Correction of CFTR malfunction and stimulation of Ca-activated Cl channels restore HCO3- secretion in cystic fibrosis bile ductular cells.
Topics: Anti-Bacterial Agents; Bicarbonates; Bile Ducts, Intrahepatic; Calcium; Cells, Cultured; Chloride Ch | 2002 |
Proceedings of the International Symposium on HCO3- and Cystic Fibrosis. San Diego, California, USA. March 3-5, 2001.
Topics: Bicarbonates; Cystic Fibrosis; Humans | 2001 |
Impaired pancreatic ductal bicarbonate secretion in cystic fibrosis.
Topics: Bicarbonates; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Human | 2001 |
Na+/HCO3- cotransport in normal and cystic fibrosis intestine.
Topics: Animals; Bicarbonates; Colon; Cystic Fibrosis; Duodenum; Humans; Intestines; Rabbits; Sodium-Bicarbo | 2001 |
Intestinal bicarbonate secretion in cystic fibrosis mice.
Topics: Animals; Bicarbonates; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regula | 2001 |
pH of sweat of patients with cystic fibrosis.
Topics: Bicarbonates; Cystic Fibrosis; Humans; Hydrogen-Ion Concentration; Sweat; Sweating | 1976 |
Does that child really have cystic fibrosis?
Topics: Amylases; Bicarbonates; Child; Child, Preschool; Chlorides; Cholecystokinin; Cystic Fibrosis; Evalua | 1978 |
[Crenotherapy in the treatment of nasal polyposis; its administration in a chlorobicarbonated, non-sulfur hot spring and in a sulfur hot spring].
Topics: Adolescent; Agammaglobulinemia; Balneology; Bicarbonates; Child; Child, Preschool; Chlorides; Cystic | 1979 |
Negative sweat tests and cystic fibrosis.
Topics: Amylases; Bicarbonates; Child; Child, Preschool; Chronic Disease; Cystic Fibrosis; Female; Humans; L | 1975 |
[Therapy of cystic fibrosis].
Topics: Anti-Bacterial Agents; Arginine; Bicarbonates; Cysteine; Cystic Fibrosis; Humans; Infant | 1976 |
cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia.
Topics: Animals; Bicarbonates; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Dogs; Epi | 1992 |
Pancreatic function and gene deletion F508 in cystic fibrosis.
Topics: Adolescent; Adult; Bicarbonates; Child; Child, Preschool; Chromosome Deletion; Chromosomes, Human, P | 1990 |
Cl- conductance and acid secretion in the human sweat duct.
Topics: Bicarbonates; Biological Transport; Chlorides; Cystic Fibrosis; Humans; Potassium; Protons; Sweat Gl | 1989 |
Origins of chloride and bicarbonate secretory defects in the cystic fibrosis pancreas, as suggested by pancreatic function studies on control and CF subjects with preserved pancreatic function.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Humans; Pancreas; Pancreatic Function Tests; Trypsin | 1989 |
Influence of antacid and formulation on effectiveness of pancreatic enzyme supplementation in cystic fibrosis.
Topics: Antacids; Bicarbonates; Cystic Fibrosis; Digestive System; Fats; Food, Formulated; Humans; Pancreati | 1987 |
Increased sulfate uptake in skin fibroblasts isolated from cystic fibrosis patients.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Bicarbonates; Biological Transport; Cell | 1988 |
Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas.
Topics: Bicarbonates; Child; Chlorides; Cystic Fibrosis; Humans; Pancreas; Pancreatic Function Tests; Pancre | 1988 |
Chloride to bicarbonate ratio in cystic fibrosis.
Topics: Bicarbonates; Child; Chlorides; Cystic Fibrosis; Humans | 1987 |
Lactate and bicarbonate uptake in the sweat duct of cystic fibrosis and normal subjects.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Humans; Hydrogen-Ion Concentration; Lactates; Lactic Acid; | 1987 |
The role of the small intestine in cystic fibrosis patients.
Topics: Bicarbonates; Biopsy; Child; Chlorides; Cystic Fibrosis; Disaccharidases; Enteropeptidase; Fatty Aci | 1985 |
Problems in the treatment of malabsorption in CF.
Topics: Bicarbonates; Bile Acids and Salts; Child; Cystic Fibrosis; Dietary Fats; Enzyme Therapy; Enzymes; G | 1985 |
Abnormal pancreatic electrolyte secretion in cystic fibrosis. Reliability as a diagnostic marker.
Topics: Adolescent; Bicarbonates; Child; Child, Preschool; Cholecystokinin; Cystic Fibrosis; Duodenum; Elect | 1986 |
[Evaluation of the function of the exocrine pancreas in childhood by stimulation with ceruletide and secretin].
Topics: Bicarbonates; Ceruletide; Child; Child, Preschool; Cystic Fibrosis; Exocrine Pancreatic Insufficienc | 1985 |
Stimulation of pancreatic secretion in man by secretin snuff.
Topics: Adolescent; Adult; Bicarbonates; Cystic Fibrosis; Duodenal Ulcer; Female; Gastric Juice; Humans; Mal | 1973 |
Diminished excretion of bicarbonate from the single sweat gland of patients with cystic fibrosis of the pancreas.
Topics: Adult; Bicarbonates; Biological Transport; Body Water; Cell Membrane Permeability; Child; Child, Pre | 1974 |
[Anion and cation elimination by the parotid gland as a function of flow rate in patients with mucoviscidosis and in healthy persons].
Topics: Bicarbonates; Calcium; Child; Child, Preschool; Cystic Fibrosis; Humans; Hydrogen-Ion Concentration; | 1974 |
[Tracheo-bronchial lavage. Pathophysiology-methods-indications-results].
Topics: Adolescent; Adult; Aged; Asthma; Bicarbonates; Bronchial Diseases; Bronchopneumonia; Child; Child, P | 1972 |
Malabsorption of crystalline vitamin B 12 in cystic fibrosis.
Topics: Adolescent; Adult; Bicarbonates; Child; Cobalt Isotopes; Crystallization; Cystic Fibrosis; Fats; Fec | 1973 |
Direct measurement of chloride in sweat with an ion-selective electrode.
Topics: Adolescent; Bicarbonates; Child; Child, Preschool; Chlorides; Cystic Fibrosis; Diagnosis, Differenti | 1973 |
[Exocrine pancreatic secretion in children. Study methods and results].
Topics: Amylases; Bicarbonates; Child; Child, Preschool; Cystic Fibrosis; Female; Humans; Infant; Infant, Ne | 1973 |
The use of L-arginine and sodium bicarbonate in the treatment of malabsorption due to cystic fibrosis.
Topics: Adolescent; Adult; Arginine; Bicarbonates; Body Weight; Carotenoids; Child; Cystic Fibrosis; Duodenu | 1972 |
Metabolic alkalosis in cystic fibrosis.
Topics: Alkalosis; Bicarbonates; Birth Weight; Cystic Fibrosis; Diet Therapy; Diseases in Twins; Female; Hum | 1971 |
[Study of exocrine pancreatic function in mucoviscidosis].
Topics: Adolescent; Amylases; Bicarbonates; Child; Child, Preschool; Cholecystokinin; Chymotrypsin; Cystic F | 1969 |
Pancreatic extracts.
Topics: Adult; Aged; Bicarbonates; Bile Acids and Salts; Cystic Fibrosis; Humans; Infant; Lipase; Malabsorpt | 1970 |
[Hypercapnia in childhood].
Topics: Age Factors; Bicarbonates; Child; Child, Preschool; Cystic Fibrosis; Female; Heart Defects, Congenit | 1970 |
The electrolyte and protein contents and outputs in duodenal juice after pancreozymin and secretin stimulation in normal children and in patients with cystic fibrosis.
Topics: Adolescent; Bicarbonates; Calcium; Child; Child, Preschool; Cholecystokinin; Cystic Fibrosis; Duoden | 1970 |
Pancreozymin secretin test of exocrine pancreatic funtion in cystic fribrosis and the significance of the result for the pathogenesis of the disease.
Topics: Adolescent; Adult; Amylases; Bicarbonates; Carboxypeptidases; Child; Child, Preschool; Chlorides; Ch | 1968 |
Quantitative assessment of exocrine pancreatic function in infants and children.
Topics: Adolescent; Age Factors; Amylases; Bicarbonates; Body Weight; Child; Child, Preschool; Cholecystokin | 1968 |