hydrogen carbonate and Complications, Pregnancy studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Research Excerpts

Excerpt	Relevance	Reference
"We report a case of baking powder pica during pregnancy that was associated with maternal hypertension, hypokalemia, and elevated liver function tests."	7.68	Baking powder pica mimicking preeclampsia. ( Barton, JR; Riely, CA; Sibai, BM, 1992)
"We report a case of baking powder pica during pregnancy that was associated with maternal hypertension, hypokalemia, and elevated liver function tests."	3.68	Baking powder pica mimicking preeclampsia. ( Barton, JR; Riely, CA; Sibai, BM, 1992)
"During a 3 1/2-year period, cardiac arrhythmias were identified in 6 of 67 horses diagnosed with duodenitis/proximal jejunitis (DPJ)."	1.28	Cardiac arrhythmias identified in horses with duodenitis/proximal jejunitis: six cases (1985-1988). ( Cornick, JL; Seahorn, TL, 1990)
"Patients with chronic renal failure requiring maintenance hemodialysis at the end of pregnancy are not as uncommon as pregnant women previously treated by this therapy."	1.27	[Preventive hemodialysis using a bath rich in bicarbonates in a pregnant woman with chronic kidney failure]. ( André, M; Beuve Méry, P; Muller, G; Ryckelynck, JP, 1983)

Research

Studies (38)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Mean Umbilical Artery Lactate at Delivery

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (78.95)	18.7374
1990's	6 (15.79)	18.2507
2000's	1 (2.63)	29.6817
2010's	1 (2.63)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Bulaeva, OA	1
Abramicheva, PA	1
Balakina, TA	1
Smirnova, OV	1
ASTRUP, A	1
HELD, HR	1
APTHORP, GH	1
MEASDAY, B	1
LEHMANN, H	2
APTHROP, GH	1
Morton, AP	1
Ryckelynck, JP	1
André, M	1
Muller, G	1
Beuve Méry, P	1
Goldfarb, JM	1
Eckel, RE	1
Merkatz, IR	1
Westgren, M	1
Divon, M	1
Horal, M	1
Ingemarsson, I	1
Kublickas, M	1
Shimojo, N	1
Nordström, L	1
Jauniaux, E	1
Jurkovic, D	1
Gulbis, B	1
Zaidi, J	1
Meuris, S	1
Campbell, S	1
Narbaitz, R	1
Kapal, VK	1
Levine, DZ	1
Margaria, E	1
Palieri Furlan, L	1
Marioni, A	1
Magro, M	1
Lovera, C	1
Atlay, RD	1
Weekes, AR	1
Entwistle, GD	1
Parkinson, DJ	1
Oh, W	1
Rawat, AK	1
Dreiling, DA	1
Bordalo, O	1
Rosenberg, V	1
Rudick, J	1
Barton, JR	1
Riely, CA	1
Sibai, BM	1
Cornick, JL	1
Seahorn, TL	1
Hutt, HJ	1
Tauber, O	1
Flach, D	1
Lang, GD	1
Dougall, A	1
Ziemer, EL	1
Parker, HR	1
Carlson, GP	1
Smith, BP	1
Narins, RG	1
Goldberg, M	1
Khatri, CK	1
Khar, DK	1
Singh, J	1
Luthra, RA	1
Vestweber, JG	1
Leipold, HW	1
Smith, JE	1
Chernukha, EA	1
Fefilov, AI	1
Unzelman, RF	1
Alderfer, GR	1
Chojnacki, RE	1
Cooperman, MT	1
Davidoff, F	1
Spark, R	1
Pallotta, J	1
Johnell, HE	1
Nilsson, BA	1
Hamilton, LA	1
Behrman, RE	1
Dayal, P	1
Murata, Y	1
Takamura, H	1
Ellison, AC	1
Maren, TH	1
Teyssou, R	1
Morin, P	1
Besan con, F	1
Wójcicka, J	1
Roszkowski, I	1
Wichrzycki, A	1
Frydrychowska, T	1
Klaus, D	1
Klumpp, F	1
Rössler, R	1
Hytten, FE	1
Robertson, EG	1
Gazárek, F	1
Skácel, K	1
Podivínský, R	1
Lhoták, J	1
Sklenárová, L	1
Lubusský, D	1
Krikal, Z	1
Marchal, C	1
Leveau, P	1
Leblanc, G	1
Heisel, J	1
Wiener, M	1
Alaoui, T	1
Birks, DA	1
Prior, VJ	1
Silk, E	1
Whittaker, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Oxygen for Category II Intrauterine Fetal Resuscitation: A Randomized, Noninferiority Trial[NCT02741284]		114 participants (Actual)	Interventional	2016-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Determined by umbilical artery cord gas collected at time of delivery and only in patients with paired (umbilical artery and umbilical vein) cord gases. (NCT02741284)
Timeframe: At delivery

Number of Patients With Resolved Recurrent Decelerations

Intervention	mmol/L (Mean)
Room Air	3.5
Oxygen	3.4

Number of patients with resolution of recurrent variable or recurrent late decelerations within 60 minutes of randomization (NCT02741284)
Timeframe: 60 minutes after randomization

Umbilical Artery Base Deficit

Intervention	Participants (Count of Participants)
No Oxygen	49
Oxygen	43

As determined by cord gas collection at time of delivery (NCT02741284)
Timeframe: At time of delivery

Umbilical Artery pCO2

Intervention	meq/L (Mean)
Room Air	-3.6
Oxygen	-3.6

Partial pressure of carbon dioxide as collected on cord gases at time of delivery (NCT02741284)
Timeframe: At time of delivery

Umbilical Artery pH

Intervention	mmHg (Mean)
Room Air	55.9
Oxygen	57.4

Determined by umbilical artery cord gas collected at time of delivery and only in patients with paired (umbilical artery and umbilical vein) cord gases. (NCT02741284)
Timeframe: At time of delivery

Umbilical Artery pO2

Intervention	pH units (Mean)
Room Air	7.26
Oxygen	7.25

Partial pressure of oxygen as collected on cord gases at time of delivery (NCT02741284)
Timeframe: Time of delivery

Mode of Delivery

Intervention	mm Hg (Mean)
Room Air	19.7
Oxygen	24.4

Delivery via Cesarean section, operative vaginal delivery (forceps or vacuum), or spontaneous vaginal delivery (NCT02741284)
Timeframe: At delivery

Article	Year
Disorder of fluid and electrolytes in newborn infants. Pediatric clinics of North America, 1976, Volume: 23, Issue:4 Topics: Bicarbonates; Dehydration; Female; Glomerular Filtration Rate; Humans; Hypernatremia; Hyponatremia;	1976
[Determination of fetal maturity by amniotic fluid (literature survey)]. Voprosy okhrany materinstva i detstva, 1972, Volume: 17, Issue:6 Topics: Alkaline Phosphatase; Amine Oxidase (Copper-Containing); Amniotic Fluid; Bicarbonates; Bilirubin; Ca	1972

Article	Year
Treating heartburn in pregnancy: comparison of acid and alkali mixtures. British medical journal, 1978, Sep-30, Volume: 2, Issue:6142 Topics: Bicarbonates; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Heartburn; H	1978
Comparative study of Algicon suspension and magnesium trisilicate mixture in the treatment of reflux dyspepsia of pregnancy. British journal of clinical practice. Supplement, 1989, Volume: 66 Topics: Adult; Alginates; Aluminum Hydroxide; Antacids; Bicarbonates; Carbonates; Female; Gastroesophageal R	1989

Article	Year
Role of Prolactin in the Regulation of Bicarbonates Biodynamics in Female Rat Model of Cholestasis of Pregnancy. Bulletin of experimental biology and medicine, 2017, Volume: 162, Issue:5 Topics: Animals; Animals, Outbred Strains; Bicarbonates; Bile; Cholestasis, Intrahepatic; Female; Glomerular	2017
[Experience with rexit suppositories in an obstetric department]. Ugeskrift for laeger, 1953, Apr-16, Volume: 115, Issue:16 Topics: Bicarbonates; Female; Humans; Potassium; Pregnancy; Pregnancy Complications; Suppositories	1953
[Prevention and treatment of gingivitis in the pregnant woman and of hypersensitivity of tooth crowns with the aid of a medicated dentifrice: anesticol]. Praxis, 1955, Dec-08, Volume: 44, Issue:49 Topics: Aluminum; Bicarbonates; Crowns; Dentifrices; Disease; Female; Gingivitis; Glycerol; Humans; Pregnanc	1955
Pregnancy in sickle-cell anaemia. Lancet (London, England), 1963, Jun-22, Volume: 1, Issue:7295 Topics: Anemia; Anemia, Sickle Cell; Bicarbonates; Female; Humans; Pregnancy; Pregnancy Complications	1963
SICKLE-CELL ANAEMIA. Proceedings of the Royal Society of Medicine, 1964, Volume: 57 Topics: Anemia, Sickle Cell; Bicarbonates; Blood Protein Electrophoresis; Cesarean Section; Female; Humans;	1964
Life-threatening milk-alkali syndrome resulting from antacid ingestion during pregnancy. The Medical journal of Australia, 2005, Jun-20, Volume: 182, Issue:12 Topics: Alkalosis; Antacids; Bicarbonates; Calcium Carbonate; Drug Labeling; Female; Histamine H2 Antagonist	2005
[Preventive hemodialysis using a bath rich in bicarbonates in a pregnant woman with chronic kidney failure]. Nephrologie, 1983, Volume: 4, Issue:4-5 Topics: Adult; Bicarbonates; Female; Humans; Kidney Failure, Chronic; Pregnancy; Pregnancy Complications; Re	1983
Salt therapy in pregnancy complicated by chronic renal disease. Obstetrics and gynecology, 1980, Volume: 56, Issue:2 Topics: Adult; Bicarbonates; Chronic Disease; Female; Humans; Nephritis, Interstitial; Pregnancy; Pregnancy	1980
Routine measurements of umbilical artery lactate levels in the prediction of perinatal outcome. American journal of obstetrics and gynecology, 1995, Volume: 173, Issue:5 Topics: Bicarbonates; Carbon Dioxide; Cesarean Section; Delivery, Obstetric; Female; Fetal Blood; Humans; Hy	1995
Biochemical composition of the coelomic fluid in anembryonic pregnancy. American journal of obstetrics and gynecology, 1994, Volume: 171, Issue:3 Topics: Bicarbonates; Body Fluids; Chorionic Gonadotropin; Female; Humans; Hydrogen-Ion Concentration; Phosp	1994
Induction of intercalated cell changes in rat pups from acid- and alkali-loaded mothers. The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 2 Topics: Acid-Base Imbalance; Alkalosis; Ammonium Chloride; Animals; Animals, Newborn; Bicarbonates; Cell Cou	1993
[Endogenous intoxications of pregnancy: jaundice of pregnancy]. Minerva anestesiologica, 1979, Volume: 45, Issue:3 Topics: Adult; Arginine; Bicarbonates; Cholestasis; Cholestyramine Resin; Dextrans; Fatty Liver; Female; Glu	1979
Effect of maternal ethanol consumption of fetal hepatic metabolism in the rat. Annals of the New York Academy of Sciences, 1976, Volume: 273 Topics: Alanine; Alcohol Oxidoreductases; Alcoholic Intoxication; Animals; Bicarbonates; Carbon Dioxide; Eth	1976
Pregnancy and Pancreatitis. The American journal of gastroenterology, 1975, Volume: 64, Issue:1 Topics: Animals; Bicarbonates; Cholecystokinin; Dogs; Female; Pancreas; Pancreatic Juice; Pancreatitis; Post	1975
Baking powder pica mimicking preeclampsia. American journal of obstetrics and gynecology, 1992, Volume: 167, Issue:1 Topics: Adult; Alum Compounds; Aspartate Aminotransferases; Bicarbonates; Bilirubin; Black People; Blood Pre	1992
Cardiac arrhythmias identified in horses with duodenitis/proximal jejunitis: six cases (1985-1988). Journal of the American Veterinary Medical Association, 1990, Oct-15, Volume: 197, Issue:8 Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Creatine Kinase; Duodenitis; Electrocardiography; Enter	1990
[Gaviscon in reflux symptoms. Results of a drug monitoring study]. Fortschritte der Medizin, 1990, Oct-30, Volume: 108, Issue:31 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alginates; Aluminum Hydroxide; Antacids; Bicarbonates; C	1990
Clinical features and treatment of renal tubular acidosis in two horses. Journal of the American Veterinary Medical Association, 1987, Feb-01, Volume: 190, Issue:3 Topics: Acidosis, Renal Tubular; Animals; Bicarbonates; Combined Modality Therapy; Female; Fluid Therapy; Ho	1987
Worsening hypokalemia and an acid-base abnormality in a pregnant woman. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1987, Volume: 9, Issue:6 Topics: Adult; Alkalosis; Bicarbonates; Carbon Dioxide; Female; Humans; Hypokalemia; Potassium; Pregnancy; P	1987
Changes in biochemical blood constituents of buffaloes with uterine torsion and the effect of caesarean section and certain post-operative therapeutic measures. Archiv fur experimentelle Veterinarmedizin, 1986, Volume: 40, Issue:3 Topics: Animals; Bicarbonates; Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Buffaloes; Calcium; Cesar	1986
Ovine ruminal acidosis: clinical studies. American journal of veterinary research, 1974, Volume: 35, Issue:12 Topics: Acidosis; Animal Feed; Animals; Bicarbonates; Blood Glucose; Body Temperature; Carbohydrates; Female	1974
Pregnancy and chronic hemodialysis. Transactions - American Society for Artificial Internal Organs, 1973, Volume: 19 Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bicarbonates; Bile A	1973
Clinical studies of alcoholic ketoacidosis. Diabetes, 1974, Volume: 23, Issue:5 Topics: Acetoacetates; Acidosis; Adult; Alcoholic Intoxication; Alcoholism; Antigens; Bicarbonates; Blood Gl	1974
Oxygen tension, acid-base status and electrolytes in human amniotic fluid. Acta obstetricia et gynecologica Scandinavica, 1971, Volume: 50, Issue:2 Topics: Acid-Base Equilibrium; Amniotic Fluid; Bicarbonates; Blood; Blood Proteins; Calcium; Carbon Dioxide;	1971
Intra-amniotic infusion of bicarbonate in the treatment of human fetal acidosis. American journal of obstetrics and gynecology, 1972, Mar-15, Volume: 112, Issue:6 Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Adult; Amniotic Fluid; Anesthesia, Spinal; Apgar Score	1972
Antepartum and postpartum acid-base changes in maternal blood in normal and complicated pregnancies. The Journal of obstetrics and gynaecology of the British Commonwealth, 1972, Volume: 79, Issue:7 Topics: Acid-Base Equilibrium; Acidosis; Alkalosis, Respiratory; Arteries; Bicarbonates; Capillaries; Carbon	1972
The effect of potassium metabolism on acetazolamide-induced teratogenesis. The Johns Hopkins medical journal, 1972, Volume: 130, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Acidosis; Administration, Oral; Amiloride; Animals; Bica	1972
[Treatment of pyrosis in pregnant women with 3 sodium bicarbonated mineral waters]. La Presse thermale et climatique, 1972, Volume: 109, Issue:1 Topics: Bicarbonates; Female; Gastrointestinal Motility; Heartburn; Humans; Mineral Waters; Pregnancy; Pregn	1972
Acid-base balance in women with jaundice in late pregnancy. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 32, Issue:1 Topics: Acid-Base Equilibrium; Alkaline Phosphatase; Bicarbonates; Bilirubin; Carbon Dioxide; Cholestasis; F	1971
[Influence of pregnancy on the Bartter syndrome]. Klinische Wochenschrift, 1971, Dec-01, Volume: 49, Issue:23 Topics: Adult; Alkalosis; Bicarbonates; Body Weight; Estrogens; Female; Gestational Age; Humans; Hyperaldost	1971
Maternal water metabolism in pregnancy. Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:10 Topics: Bicarbonates; Connective Tissue; Diuresis; Edema; Extracellular Space; Female; Humans; Osmolar Conce	1971
[Possibilities to affect the acid-base equilibrium in the parturient and the fetus]. Ceskoslovenska gynekologie, 1969, Volume: 34, Issue:9 Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Female; Fetal Diseases; Glucose; Humans; Infant, Newb	1969
[Prophylaxis of idiopathic neonatal respiratory distress (I.R.D.). Influence of alkalinization in the delivery room]. Annales de pediatrie, 1970, Mar-02, Volume: 17, Issue:3 Topics: Acidosis; Age Factors; Bicarbonates; Delivery, Obstetric; Female; Humans; Infant, Newborn; Infant, P	1970
Echothiophate iodide treatment of glaucoma in pregnancy. Archives of ophthalmology (Chicago, Ill. : 1960), 1968, Volume: 79, Issue:3 Topics: Acetazolamide; Adult; Betamethasone; Bicarbonates; Cholinesterase Inhibitors; Cholinesterases; Echot	1968

hydrogen carbonate and Complications, Pregnancy