hydrogen carbonate has been researched along with Brain Ischemia in 17 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum lactic acidosis is characterized by a pH less than 7." | 5.27 | Comparison of sodium bicarbonate with dichloroacetate treatment of hyperlactatemia and lactic acidosis in the ischemic rat. ( Biros, MH; Dimlich, RV; Kaplan, J; Widman, DW, 1988) |
| "Ischemic stroke is a prevalent, devastating disease with high morbidity and mortality." | 3.11 | Alterations in Local Peri-Infarct Blood Gases in Stroke Patients Undergoing Thrombectomy. ( Frank, JA; Fraser, JF; Maglinger, B; Martha, S; McLouth, CJ; Pahwa, S; Pennypacker, KR; Roberts, J; Sheikhi, L; Spears, RC; Stowe, AM; Trout, AL, 2022) |
| "Special attention is given to brain death and prognostication." | 2.37 | Cardiopulmonary arrest. Pathophysiology and neurologic complications. ( Bass, E, 1985) |
| "Tirilazad attenuates cerebral edema and improves somatosensory evoked potential recovery after incomplete ischemia associated with severe acidosis." | 1.29 | Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia. ( Blizzard, KK; Kirsch, JR; Koehler, RC; Maruki, Y; Traystman, RJ, 1993) |
| "Metabolic acidosis in cerebral ischemia is considered deleterious to cell function and neurological outcome." | 1.28 | [Experimental studies on the therapeutic effects of alkalizing agents on acute focal cerebral ischemia]. ( Fujita, K, 1992) |
| "Serum lactic acidosis is characterized by a pH less than 7." | 1.27 | Comparison of sodium bicarbonate with dichloroacetate treatment of hyperlactatemia and lactic acidosis in the ischemic rat. ( Biros, MH; Dimlich, RV; Kaplan, J; Widman, DW, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (41.18) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Spears, RC | 1 |
| McLouth, CJ | 1 |
| Pennypacker, KR | 1 |
| Frank, JA | 1 |
| Maglinger, B | 1 |
| Martha, S | 1 |
| Trout, AL | 1 |
| Roberts, J | 1 |
| Stowe, AM | 1 |
| Sheikhi, L | 1 |
| Pahwa, S | 1 |
| Fraser, JF | 1 |
| Hyacinthe, JN | 1 |
| Buscemi, L | 1 |
| Lê, TP | 1 |
| Lepore, M | 1 |
| Hirt, L | 1 |
| Mishkovsky, M | 1 |
| Bulli, I | 1 |
| Dettori, I | 1 |
| Coppi, E | 1 |
| Cherchi, F | 1 |
| Venturini, M | 1 |
| Di Cesare Mannelli, L | 1 |
| Ghelardini, C | 1 |
| Nocentini, A | 1 |
| Supuran, CT | 1 |
| Pugliese, AM | 1 |
| Pedata, F | 1 |
| Kozlova, EM | 1 |
| Remizova, NV | 1 |
| Khaletskaia, OV | 1 |
| Hertz, L | 1 |
| Mercier, JC | 1 |
| Bompard, Y | 1 |
| Beaufils, F | 1 |
| Puka, M | 1 |
| Lehmann, A | 1 |
| Eleff, SM | 2 |
| Kim, H | 1 |
| Shaffner, DH | 1 |
| Traystman, RJ | 3 |
| Koehler, RC | 3 |
| Maruki, Y | 2 |
| Kirsch, JR | 1 |
| Blizzard, KK | 1 |
| Fujita, K | 1 |
| Siesjö, BK | 2 |
| Ekholm, A | 1 |
| Katsura, K | 1 |
| Theander, S | 1 |
| Dimlich, RV | 1 |
| Biros, MH | 1 |
| Widman, DW | 1 |
| Kaplan, J | 1 |
| Kraig, RP | 2 |
| Pulsinelli, WA | 2 |
| Plum, F | 2 |
| Bass, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Brain, Blood And Clot or Tissue Registry And Collaboration (BACTRAC)[NCT03153683] | 1,000 participants (Anticipated) | Observational | 2017-05-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for hydrogen carbonate and Brain Ischemia
| Article | Year |
|---|---|
Role of Carbonic Anhydrase in Cerebral Ischemia and Carbonic Anhydrase Inhibitors as Putative Protective Agents.
Topics: Bicarbonates; Brain; Brain Ischemia; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydra | 2021 |
Features of astrocytic function apparently involved in the response of central nervous tissue to ischemia-hypoxia.
Topics: Animals; Astrocytes; Bicarbonates; Biological Transport, Active; Brain Ischemia; Carbon Dioxide; Cel | 1981 |
[Cardiopulmonary resuscitation. Current findings].
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bicarbonates; Blood Circulation; Brain Ischemia | 1983 |
Acid-base changes during complete brain ischemia.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Adenosine Triphosphate; Bicarbonates; Brain Ische | 1990 |
Cardiopulmonary arrest. Pathophysiology and neurologic complications.
Topics: Amnesia; Animals; Anticonvulsants; Barbiturates; Bicarbonates; Blindness; Brain Death; Brain Disease | 1985 |
Acid-base homeostasis in the brain: physiology, chemistry, and neurochemical pathology.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Bicarbonates; Brain; Brain Damage, Chronic; Brain Ischemia | 1985 |
1 trial available for hydrogen carbonate and Brain Ischemia
| Article | Year |
|---|---|
Alterations in Local Peri-Infarct Blood Gases in Stroke Patients Undergoing Thrombectomy.
Topics: Animals; Bicarbonates; Brain Ischemia; Female; Gases; Humans; Infarction; Male; Oxygen; Stroke; Thro | 2022 |
10 other studies available for hydrogen carbonate and Brain Ischemia
| Article | Year |
|---|---|
Evaluating the potential of hyperpolarised [1-
Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis | 2020 |
[Hydrocephaly in newborns with perinatal brain damage of moderate severity].
Topics: Acetazolamide; Bicarbonates; Brain Ischemia; Cerebral Ventricles; Cerebrovascular Circulation; Creat | 2009 |
In vivo acidosis reduces extracellular concentrations of taurine and glutamate in the rat hippocampus.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acidosis; Animals; Antiporters; Bicarbonates; Brai | 1994 |
Effect of cerebral blood flow generated during cardiopulmonary resuscitation in dogs on maintenance versus recovery of ATP and pH.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Blood Pressure; Brain; Brain Ischemia; Cardiopulmonar | 1993 |
Intracellular pH during reperfusion influences evoked potential recovery after complete cerebral ischemia.
Topics: Acetazolamide; Acidosis; Animals; Bicarbonates; Brain Ischemia; Carbon Dioxide; Cytoplasm; Dogs; Evo | 1993 |
Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia.
Topics: Acidosis; Adenosine Triphosphate; Animals; Bicarbonates; Brain; Brain Edema; Brain Ischemia; Cytopla | 1993 |
[Experimental studies on the therapeutic effects of alkalizing agents on acute focal cerebral ischemia].
Topics: Acidosis; Animals; Bicarbonates; Blood Pressure; Body Water; Brain; Brain Edema; Brain Ischemia; Cat | 1992 |
Comparison of sodium bicarbonate with dichloroacetate treatment of hyperlactatemia and lactic acidosis in the ischemic rat.
Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Blood Glucose; Brain Chemistry; Brain Ischemia; D | 1988 |
Carbonic acid buffer changes during complete brain ischemia.
Topics: Animals; Bicarbonates; Brain; Brain Ischemia; Buffers; Carbon Dioxide; Carbonates; Carbonic Acid; Hy | 1986 |
Heterogeneous distribution of hydrogen and bicarbonate ions during complete brain ischemia.
Topics: Animals; Bicarbonates; Brain Ischemia; Hydrogen; Mammals; Tissue Distribution | 1985 |