hydrogen carbonate has been researched along with Brain Edema in 58 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of cerebral edema includes fluid restriction and administration of mannitol." | 2.44 | Management of diabetic ketoacidosis in children and adolescents. ( Levitsky, LL; Sherry, NA, 2008) |
| "Diabetic ketoacidosis has a mortality of up to 14% in the UK, which could be attributed to varied treatment policies and a lack of a general consensus statement on its management." | 2.44 | Diabetic ketoacidosis: principles of management. ( Hadebe, N; Sharma, V, 2007) |
| "Studies included reports in diabetic ketoacidosis where arterial and CSF acid-base data have been presented." | 2.43 | Hyperventilation in severe diabetic ketoacidosis. ( Lutman, D; Peters, MJ; Tasker, RC, 2005) |
| "This article reviews the pathogenesis of diabetic ketoacidosis (DKA) and provides a rational approach to the management of patients with DKA." | 2.39 | Diabetic ketoacidosis. ( Kitabchi, AE; Wall, BM, 1995) |
| "Special attention is given to brain death and prognostication." | 2.37 | Cardiopulmonary arrest. Pathophysiology and neurologic complications. ( Bass, E, 1985) |
| "Cerebral edema in diabetic ketoacidosis (DKA-CE) occurs primarily in children and can develop during DKA therapy." | 1.34 | Combined insulin and bicarbonate therapy elicits cerebral edema in a juvenile mouse model of diabetic ketoacidosis. ( Fraser, DD; Pin, CL; Rose, KL; Wang, R, 2007) |
| "Diabetic ketoacidosis is an important complication of diabetes in children and is the most frequent diabetes-related cause of death in childhood." | 1.33 | Pediatric diabetic ketoacidosis and hyperglycemic hyperosmolar state. ( Glaser, N, 2005) |
| "A comparison of the children with cerebral edema with those in the matched control group also showed that cerebral edema was associated with lower partial pressures of arterial carbon dioxide and higher serum urea nitrogen concentrations." | 1.31 | Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. ( Barnett, P; Glaser, N; Kaufman, F; Kuppermann, N; Louie, J; Malley, R; McCaslin, I; Nelson, D; Quayle, K; Roback, M; Trainor, J, 2001) |
| "Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies." | 1.30 | Putaminal infarct in methanol intoxication: case report and role of brain imaging studies. ( Frank, LR; Krenzelok, EP; Roberge, RJ; Scorza, L; Srinivasa, NS, 1998) |
| "Tirilazad attenuates cerebral edema and improves somatosensory evoked potential recovery after incomplete ischemia associated with severe acidosis." | 1.29 | Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia. ( Blizzard, KK; Kirsch, JR; Koehler, RC; Maruki, Y; Traystman, RJ, 1993) |
| "Metabolic acidosis in cerebral ischemia is considered deleterious to cell function and neurological outcome." | 1.28 | [Experimental studies on the therapeutic effects of alkalizing agents on acute focal cerebral ischemia]. ( Fujita, K, 1992) |
| "In this age group, cerebral edema, rapid decreases of serum potassium levels and severe hypoglycaemia seem to represent the most frequent complications of therapy which have to be avoided." | 1.27 | [Treatment of diabetic ketoacidosis in children and adolescents]. ( Burger, W; Weber, B, 1983) |
| "Prophylaxis and treatment of cerebral edema with dexamethasone is of equal importance to primary emergency therapy and reanimation." | 1.25 | [Clinic and therapy of the so-called hyperosmolar syndrome in childhood (author's transl)]. ( Emmrich, P; Stechele, U, 1975) |
| "A young man with diabetic ketoacidosis developed the clinical features of cerebral oedema." | 1.25 | Reversible cerebral oedema complicating diabetic ketoacidosis. ( Metzger, AL; Rubenstein, AH, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (60.34) | 18.7374 |
| 1990's | 9 (15.52) | 18.2507 |
| 2000's | 11 (18.97) | 29.6817 |
| 2010's | 3 (5.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamel, KS | 2 |
| Halperin, ML | 2 |
| Sherry, NA | 1 |
| Levitsky, LL | 1 |
| Sivanandan, S | 1 |
| Sinha, A | 1 |
| Jain, V | 1 |
| Lodha, R | 1 |
| Kimura, D | 1 |
| Raszynski, A | 1 |
| Totapally, BR | 1 |
| Glaser, N | 3 |
| Kuppermann, N | 2 |
| Hisatomi, A | 1 |
| Tasker, RC | 1 |
| Lutman, D | 1 |
| Peters, MJ | 1 |
| Turan, S | 1 |
| Guran, T | 1 |
| Topcu, B | 1 |
| Akcay, T | 1 |
| Bereket, A | 1 |
| Maccari, C | 1 |
| Carlotti, AP | 1 |
| Bohn, D | 1 |
| Rose, KL | 1 |
| Pin, CL | 1 |
| Wang, R | 1 |
| Fraser, DD | 1 |
| Sharma, V | 1 |
| Hadebe, N | 1 |
| Foster, DW | 2 |
| McGarry, JD | 2 |
| Burger, W | 1 |
| Weber, B | 1 |
| Sperling, MA | 1 |
| Karch, D | 1 |
| Kitabchi, AE | 1 |
| Wall, BM | 1 |
| Maruki, Y | 1 |
| Koehler, RC | 1 |
| Kirsch, JR | 1 |
| Blizzard, KK | 1 |
| Traystman, RJ | 1 |
| Roberge, RJ | 1 |
| Srinivasa, NS | 1 |
| Frank, LR | 1 |
| Scorza, L | 1 |
| Krenzelok, EP | 1 |
| Barnett, P | 1 |
| McCaslin, I | 1 |
| Nelson, D | 1 |
| Trainor, J | 1 |
| Louie, J | 1 |
| Kaufman, F | 1 |
| Quayle, K | 1 |
| Roback, M | 1 |
| Malley, R | 1 |
| Dunger, DB | 1 |
| Edge, JA | 1 |
| Tertsch, D | 1 |
| Bluhm, H | 1 |
| Seitz, HD | 1 |
| Matakas, F | 1 |
| Birkle, J | 1 |
| Cervós-Navarro, J | 1 |
| Jelen, S | 1 |
| Kaye, R | 1 |
| Moore, J | 1 |
| Schall, WD | 1 |
| Cornelius, LM | 1 |
| Bourke, RS | 1 |
| Kimelberg, HK | 1 |
| Dazé, MA | 1 |
| Frier, BM | 1 |
| Vinik, AI | 1 |
| Golden, FS | 1 |
| Rivers, JF | 1 |
| Emmrich, P | 1 |
| Stechele, U | 1 |
| Fujita, K | 1 |
| Shabbir, N | 1 |
| Oberfield, SE | 1 |
| Corrales, R | 1 |
| Kairam, R | 1 |
| Levine, LS | 1 |
| Durr, JA | 1 |
| Hoffman, WH | 1 |
| Sklar, AH | 1 |
| el Gammal, T | 1 |
| Steinhart, CM | 1 |
| Ishikawa, T | 1 |
| Setoyama, K | 1 |
| Wakitani, K | 1 |
| Kubo, M | 1 |
| Maekawa, T | 1 |
| Sakabe, T | 1 |
| Takeshita, H | 1 |
| Greene, SA | 1 |
| Jefferson, IG | 1 |
| Baum, JD | 1 |
| Brun, TH | 1 |
| Lagier, P | 1 |
| Dejode, JM | 1 |
| Attali, T | 1 |
| Soula, F | 1 |
| Granthil, C | 1 |
| Matz, R | 2 |
| Griffith, DN | 1 |
| Yudkin, JS | 1 |
| Bass, E | 1 |
| Felig, P | 1 |
| Dittmann, J | 2 |
| Herrmann, HD | 2 |
| Loew, F | 2 |
| von Steinäcker, B | 1 |
| Murray, JD | 1 |
| Fleming, P | 1 |
| Weber, J | 1 |
| Hsuen, J | 1 |
| Bannatyne, R | 1 |
| Anglin, C | 1 |
| Pokrovskiĭ, VI | 1 |
| Cherniaeva, TE | 1 |
| Taubin, H | 1 |
| Manigand, G | 1 |
| Auzepy, P | 1 |
| Jan, F | 1 |
| Leguillant, J | 1 |
| Deparis, M | 1 |
| Metzger, AL | 1 |
| Rubenstein, AH | 1 |
| Winegrad, AI | 1 |
| Clements, RS | 1 |
| Zupping, R | 2 |
| Obermann, U | 1 |
| Metzel, E | 1 |
| Zimmermann, WE | 1 |
| Reske-Nielsen, E | 1 |
| Kratholm, S | 1 |
| Gläsel, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 Diabetes.[NCT01477476] | Phase 2 | 0 participants (Actual) | Interventional | 2012-03-31 | Withdrawn (stopped due to funding loss, no data was ever collected) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for hydrogen carbonate and Brain Edema
| Article | Year |
|---|---|
Acid-base problems in diabetic ketoacidosis.
Topics: Acid-Base Equilibrium; Bicarbonates; Brain Edema; Child; Diabetic Ketoacidosis; Fatty Acids; Humans; | 2015 |
Management of diabetic ketoacidosis in children and adolescents.
Topics: Adolescent; Bicarbonates; Brain Edema; Child; Diabetic Ketoacidosis; Electrolytes; Fluid Therapy; Hu | 2008 |
The evaluation and management of children with diabetic ketoacidosis in the emergency department.
Topics: Adolescent; Bicarbonates; Brain Edema; Case Management; Child; Child, Preschool; Combined Modality T | 2004 |
[Progress in diagnosis of and therapy for diabetic ketoacidosis].
Topics: Bicarbonates; Biomarkers; Brain Edema; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Dietary Car | 2004 |
Hyperventilation in severe diabetic ketoacidosis.
Topics: Acid-Base Equilibrium; Bicarbonates; Brain Edema; Carbon Dioxide; Cerebrovascular Circulation; Child | 2005 |
Diabetic ketoacidosis: principles of management.
Topics: Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Diagnosis, Differential; Fluid Therapy; Humans; Hy | 2007 |
The metabolic derangements and treatment of diabetic ketoacidosis.
Topics: Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Fluid Therapy; Glucose; Humans; Infections; Insuli | 1983 |
Diabetic ketoacidosis.
Topics: Bicarbonates; Brain Edema; Child; Child, Preschool; Diabetic Ketoacidosis; Epinephrine; Fluid Therap | 1984 |
[Hypoxia during the perinatal period and the formation of cerebral lesions].
Topics: Acidosis; Animals; Animals, Newborn; Bicarbonates; Brain; Brain Damage, Chronic; Brain Edema; Cerebr | 1982 |
Diabetic ketoacidosis.
Topics: Acidosis; Bicarbonates; Brain Edema; Chlorides; Diabetic Ketoacidosis; Emergencies; Fluid Therapy; H | 1995 |
Diabetes mellitus.
Topics: Animals; Bicarbonates; Blood Glucose; Brain Edema; Cat Diseases; Cats; Diabetes Mellitus; Diabetic C | 1977 |
The immersion incident.
Topics: Acid-Base Equilibrium; Adult; Bicarbonates; Body Temperature; Brain Edema; Child; Cold Temperature; | 1975 |
[Fatal acute cerebral edema in a diabetic child].
Topics: Adolescent; Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Extracellular Space; Fluid Therapy; Hu | 1990 |
Cardiopulmonary arrest. Pathophysiology and neurologic complications.
Topics: Amnesia; Animals; Anticonvulsants; Barbiturates; Bicarbonates; Blindness; Brain Death; Brain Disease | 1985 |
Diabetic ketoacidosis.
Topics: Bicarbonates; Blood Glucose; Brain Edema; Dehydration; Diabetic Ketoacidosis; Glucose; Humans; Infus | 1974 |
The continuing problem of purulent meningitis in infants and children.
Topics: Bacterial Vaccines; Bicarbonates; Brain Edema; Diagnosis, Differential; Diazepam; Digoxin; Fever; Ga | 1974 |
Regulation of ketogenesis and clinical aspects of the ketotic state.
Topics: Bicarbonates; Brain Edema; Citric Acid Cycle; Coenzyme A; Diabetic Ketoacidosis; Fatty Acids; Glycer | 1972 |
Diabetic ketoacidosis.
Topics: Acute Kidney Injury; Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Humans; Hypertension; Insulin | 1971 |
40 other studies available for hydrogen carbonate and Brain Edema
| Article | Year |
|---|---|
Management of diabetic ketoacidosis.
Topics: Bicarbonates; Brain Edema; Child; Diabetic Ketoacidosis; Fluid Therapy; Humans; Hypoglycemic Agents; | 2011 |
Admission and treatment factors associated with the duration of acidosis in children with diabetic ketoacidosis.
Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Bicarbonates; Brain Edema; Child; Child, Preschool; Chl | 2012 |
Pediatric diabetic ketoacidosis and hyperglycemic hyperosmolar state.
Topics: Abdominal Pain; Bicarbonates; Brain Edema; Child; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; | 2005 |
Severe diabetic ketoacidosis: hyperventilation or relative hypoventilation.
Topics: Acid-Base Equilibrium; Bicarbonates; Brain Edema; Carbon Dioxide; Cerebrovascular Circulation; Child | 2006 |
Strategies to diminish the danger of cerebral edema in a pediatric patient presenting with diabetic ketoacidosis.
Topics: Bicarbonates; Brain Edema; Carbon Dioxide; Cell Size; Child; Diabetic Ketoacidosis; Extracellular Sp | 2006 |
Combined insulin and bicarbonate therapy elicits cerebral edema in a juvenile mouse model of diabetic ketoacidosis.
Topics: Animals; Bicarbonates; Brain Edema; Child; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; D | 2007 |
[Treatment of diabetic ketoacidosis in children and adolescents].
Topics: Adult; Bicarbonates; Brain Edema; Child; Diabetic Ketoacidosis; Fluid Therapy; Humans; Hypoglycemia; | 1983 |
Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia.
Topics: Acidosis; Adenosine Triphosphate; Animals; Bicarbonates; Brain; Brain Edema; Brain Ischemia; Cytopla | 1993 |
Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.
Topics: Adult; Basal Ganglia; Bicarbonates; Brain Edema; Cerebral Infarction; Fatal Outcome; Female; Humans; | 1998 |
Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics.
Topics: Age Factors; Bicarbonates; Blood Urea Nitrogen; Brain Edema; Carbon Dioxide; Case-Control Studies; C | 2001 |
Predicting cerebral edema during diabetic ketoacidosis.
Topics: Bicarbonates; Blood Urea Nitrogen; Brain Edema; Carbon Dioxide; Child; Diabetic Ketoacidosis; Humans | 2001 |
[Electrolyte-water balance and acid-base equilibrium in brain tumor patients].
Topics: Acid-Base Imbalance; Bicarbonates; Brain Edema; Brain Neoplasms; Carbon Dioxide; Diuretics; Electrol | 1977 |
[Gas levels and biochemical changes in cerebrospinal fluid after experimental brain injury: its effect on cerebral circulation and cerebral metabolism as well as its management].
Topics: Animals; Bicarbonates; Blood Pressure; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Cerebrova | 1976 |
The effect of prolonged experimental hypercapnia on the brain.
Topics: Animals; Bicarbonates; Blood-Brain Barrier; Body Weight; Brain; Brain Edema; Electroencephalography; | 1978 |
[Lightning injuries: emergency help].
Topics: Acidosis; Bicarbonates; Brain Edema; Dexamethasone; Diuretics; Electric Injuries; Emergencies; Heart | 1979 |
Diabetic ketoacidosis--the bicarbonate controversy.
Topics: Acid-Base Equilibrium; Bicarbonates; Brain Edema; Child; Diabetes Mellitus, Type 1; Diabetic Ketoaci | 1975 |
Letter: Cerebral oedema in diabetic ketoacidosis.
Topics: Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Female; Humans; Hydrogen-Ion Concentration; Myocar | 1975 |
Effects of inhibitors and adenosine on (HCO3-/CO2)-stimulated swelling and Cl- uptake in brain slices and cultured astrocytes.
Topics: Adenosine; Animals; Astrocytes; Bicarbonates; Brain; Brain Edema; Carbon Dioxide; Cats; Chlorides; C | 1978 |
Letter: Cerebral oedema in diabetic ketoacidosis.
Topics: Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Heart Arrest; Humans | 1975 |
Current trends in the management of diabetic keto-acidotic coma.
Topics: Bicarbonates; Brain Edema; Diabetic Coma; Humans; Insulin; Phosphates; Potassium | 1976 |
[Clinic and therapy of the so-called hyperosmolar syndrome in childhood (author's transl)].
Topics: Acidosis; Bicarbonates; Brain Edema; Child, Preschool; Chlorides; Dexamethasone; Dextrans; First Aid | 1975 |
[Experimental studies on the therapeutic effects of alkalizing agents on acute focal cerebral ischemia].
Topics: Acidosis; Animals; Bicarbonates; Blood Pressure; Body Water; Brain; Brain Edema; Brain Ischemia; Cat | 1992 |
Recovery from symptomatic brain swelling in diabetic ketoacidosis.
Topics: Bicarbonates; Brain Edema; Child, Preschool; Dexamethasone; Diabetes Mellitus, Type 1; Diabetic Keto | 1992 |
Correlates of brain edema in uncontrolled IDDM.
Topics: Adolescent; Arginine Vasopressin; Bicarbonates; Blood Glucose; Brain; Brain Edema; Child; Diabetes M | 1992 |
[Effects of ONO-1016, inhibitor of C1-/HCO3- exchange, on the brain water content and local cerebral blood flow following cerebral ischemia in spontaneously hypertensive rats].
Topics: Animals; Bicarbonates; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Cerebrovascular Circulat | 1991 |
Cerebral oedema complicating diabetic ketoacidosis.
Topics: Adolescent; Bicarbonates; Blood Glucose; Brain Edema; Child; Dehydration; Diabetic Coma; Diabetic Ke | 1990 |
Cerebral oedema in diabetic ketoacidosis.
Topics: Adult; Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Female; Humans; Insulin; Sodium; Sodium Bic | 1987 |
Diabetic ketoacidosis.
Topics: Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Humans; Insulin; Phosphates; Respiratory Distress | 1986 |
Examination of the metabolism of oedematous brain tissue. IV. The influence of carbon dioxide, bicarbonate and pH on respiration and aerobic glycolysis of normal and oedematous rabbit brain in vitro.
Topics: Animals; Bicarbonates; Brain; Brain Chemistry; Brain Edema; Carbon Dioxide; Glycolysis; Hydrogen-Ion | 1974 |
Diabetes mellitus--problems of keto-acidosis.
Topics: Adolescent; Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Humans; Infusions, Parenteral; Insulin | 1972 |
[Arterial blood and cerebrospinal fluid acid-base balance in meningococcal meningitis patients with manifestations of cerebral edema].
Topics: Acid-Base Equilibrium; Adolescent; Adult; Alkalosis, Respiratory; Bicarbonates; Blood Gas Analysis; | 1973 |
Cerebral edema, diabetes insipidus, and sudden death during the treatment of diabetic ketoacidosis.
Topics: Adult; Arrhythmias, Cardiac; Bicarbonates; Brain Edema; Death, Sudden; Diabetes Insipidus; Diabetic | 1968 |
[Death due to cerebral edema in the course of severe diabetic acido-ketosis].
Topics: Adolescent; Bicarbonates; Blood Glucose; Blood-Brain Barrier; Brain; Brain Edema; Carbon Dioxide; Ce | 1969 |
Reversible cerebral oedema complicating diabetic ketoacidosis.
Topics: Acetone; Adolescent; Bicarbonates; Blood Glucose; Brain Edema; Diabetic Ketoacidosis; Glucose; Human | 1970 |
Cerebral metabolism in patients with intracranial tumors.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Respiratory; Adolescent; Adult; Aged; Bicarbonates; Brain | 1972 |
Examination of the metabolism of oedematous brain tissue. II. The influence of the glucose concentration on the respiration and the aerobic glycolysis of normal and oedematous rabbit brain in vitro.
Topics: Animals; Bicarbonates; Brain; Brain Edema; Carbon Dioxide; Glucose; Glycolysis; Lactates; Oxygen Con | 1972 |
Changes of oxygen pressure, acid-base balance, metabolites and electrolytes in cerebrospinal fluid and blood after cerebral injury.
Topics: Acid-Base Equilibrium; Bicarbonates; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Chlorides; | 1971 |
Malignant hyperthermia. A fatal case provoked by anaesthesia in asymptomatic encephalitis?
Topics: Acidosis; Anesthesia; Autopsy; Bicarbonates; Brain Edema; Central Nervous System; Child; Fever; Halo | 1971 |
Cerebral acid-base and gas metabolism in brain injury.
Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Blood Gas Analysis; Brain Edema; Brain Injuries; Carb | 1970 |
[Clinical aspect and therapy of a severe acute dinitroorthocresol poisoning].
Topics: Acidosis; Adenosine Triphosphate; Adult; Bicarbonates; Bloodletting; Brain Edema; Carbohydrates; Cre | 1970 |