hydrogen carbonate has been researched along with Aura in 34 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy." | 9.15 | The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy. ( Heo, K; Kim, WJ; Lee, BI; Lee, HW; Lee, SA; Rhee, Y; Shin, DJ; Song, HK; Song, K, 2011) |
| "A 3-year-old neutered male golden retriever administered zonisamide for the treatment of seizures showed lethargy and had normal anion gap metabolic acidosis with hypokalaemia, hyperchloremia, and alkaline urine." | 8.12 | Distal renal tubular acidosis and lethargy associated with zonisamide treatment in a dog with idiopathic epilepsy. ( Akashi, N; Hata, A; Itoi, T; Kanda, T; Kutara, K; Miyama, TS; Shimizu, Y; Sugimoto, K, 2022) |
| "Topiramate (TPM) is widely used as add-on therapy for epilepsy." | 7.71 | Concomitant treatment with topiramate and ketogenic diet in pediatric epilepsy. ( Pfeifer, H; Riviello, JJ; Takeoka, M; Thiele, EA, 2002) |
| "Topiramate (TPM) has been widely used as an adjunctive therapy for treating epilepsy." | 7.71 | Topiramate and metabolic acidosis in pediatric epilepsy. ( Bourgeois, BF; Duffy, FH; Helmers, SL; Holmes, GL; Riviello, JJ; Takeoka, M; Thiele, E, 2001) |
| "Two children who presented with symptomatic metabolic acidosis after being put on topiramate (TPM) are reported." | 7.71 | Topiramate-induced metabolic acidosis: report of two cases. ( Ko, CH; Kong, CK, 2001) |
| "Topiramate (TPM) inhibits carbonic anhydrase, with metabolic acidosis as a possible side effect, although this has been reported in only two adult cases." | 7.71 | Topiramate and metabolic acidosis in infants and toddlers. ( Boor, R; Philippi, H; Reitter, B, 2002) |
| "Topiramate is a recently released antiepileptic agent used in the treatment of patients with refractory seizure disorders." | 5.31 | Central hyperventilation related to administration of topiramate. ( Korn, DE; Laskey, AL; Moorjani, BI; Patel, NC; Tobias, JD, 2000) |
| "To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy." | 5.15 | The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy. ( Heo, K; Kim, WJ; Lee, BI; Lee, HW; Lee, SA; Rhee, Y; Shin, DJ; Song, HK; Song, K, 2011) |
| "A 3-year-old neutered male golden retriever administered zonisamide for the treatment of seizures showed lethargy and had normal anion gap metabolic acidosis with hypokalaemia, hyperchloremia, and alkaline urine." | 4.12 | Distal renal tubular acidosis and lethargy associated with zonisamide treatment in a dog with idiopathic epilepsy. ( Akashi, N; Hata, A; Itoi, T; Kanda, T; Kutara, K; Miyama, TS; Shimizu, Y; Sugimoto, K, 2022) |
| "Topiramate, which is commonly prescribed for seizure disorders and migraine prophylaxis, sometimes causes metabolic acidosis and hypokalemia." | 3.76 | Chronic impact of topiramate on acid-base balance and potassium in childhood. ( Belotti, EA; Bianchetti, MG; Pifferini, R; Ragazzi, M; Ramelli, GP; Simonetti, GD; Taddeo, I, 2010) |
| "Topiramate was associated with metabolic acidosis in 48% of the patients studied, which did not result in clinically significant problems." | 3.73 | Impact of topiramate on serum bicarbonate concentrations in adults. ( Garris, SS; Oles, KS, 2005) |
| "Topiramate (TPM) is widely used as add-on therapy for epilepsy." | 3.71 | Concomitant treatment with topiramate and ketogenic diet in pediatric epilepsy. ( Pfeifer, H; Riviello, JJ; Takeoka, M; Thiele, EA, 2002) |
| "Topiramate (TPM) has been widely used as an adjunctive therapy for treating epilepsy." | 3.71 | Topiramate and metabolic acidosis in pediatric epilepsy. ( Bourgeois, BF; Duffy, FH; Helmers, SL; Holmes, GL; Riviello, JJ; Takeoka, M; Thiele, E, 2001) |
| "Two children who presented with symptomatic metabolic acidosis after being put on topiramate (TPM) are reported." | 3.71 | Topiramate-induced metabolic acidosis: report of two cases. ( Ko, CH; Kong, CK, 2001) |
| "Topiramate (TPM) inhibits carbonic anhydrase, with metabolic acidosis as a possible side effect, although this has been reported in only two adult cases." | 3.71 | Topiramate and metabolic acidosis in infants and toddlers. ( Boor, R; Philippi, H; Reitter, B, 2002) |
| "Differentiation between psychogenic nonepileptic seizures (PNES) and generalized convulsive epileptic seizures (ES) is important for appropriate triaging in the emergency department (ED)." | 1.46 | Anion gap can differentiate between psychogenic and epileptic seizures in the emergency setting. ( Li, Y; Maranda, L; Matzka, L; Weber, D, 2017) |
| "Topiramate (TPM) is an anticonvulsant whose impact on firing activity and intracellular pH (pHi) regulation of CA3 neurons was investigated." | 1.32 | Topiramate modulates pH of hippocampal CA3 neurons by combined effects on carbonic anhydrase and Cl-/HCO3- exchange. ( Leniger, T; Thöne, J; Wiemann, M, 2004) |
| "Topiramate is a recently released antiepileptic agent used in the treatment of patients with refractory seizure disorders." | 1.31 | Central hyperventilation related to administration of topiramate. ( Korn, DE; Laskey, AL; Moorjani, BI; Patel, NC; Tobias, JD, 2000) |
| "In patients presenting in an unconscious state, increased lactate levels, even when determined up to 2 hours after venous blood withdrawal, could be a useful parameter for the diagnosis of epileptic seizure." | 1.30 | [Losing consciousness: role of the venous lactate levels in the diagnosis of convulsive crises]. ( Dequin, PF; Ferrandière, M; Hazouard, E; Lanotte, R; Legras, A; Perrotin, D, 1998) |
| "In audiogenic seizure mice, glial CA activity is increased and glial anion transport is reduced." | 1.27 | Ionic and acid-base regulation of neurons and glia during seizures. ( Chen, CF; Chow, SY; Engstrom, FL; Kemp, JW; White, HS; Woodbury, DM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (47.06) | 18.7374 |
| 1990's | 4 (11.76) | 18.2507 |
| 2000's | 9 (26.47) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Itoi, T | 1 |
| Akashi, N | 1 |
| Shimizu, Y | 1 |
| Sugimoto, K | 1 |
| Hata, A | 1 |
| Kutara, K | 1 |
| Miyama, TS | 1 |
| Kanda, T | 1 |
| Li, Y | 1 |
| Matzka, L | 1 |
| Maranda, L | 1 |
| Weber, D | 1 |
| Belotti, EA | 1 |
| Taddeo, I | 1 |
| Ragazzi, M | 1 |
| Pifferini, R | 1 |
| Simonetti, GD | 1 |
| Bianchetti, MG | 1 |
| Ramelli, GP | 1 |
| Viitanen, T | 1 |
| Ruusuvuori, E | 1 |
| Kaila, K | 1 |
| Voipio, J | 1 |
| Heo, K | 1 |
| Rhee, Y | 1 |
| Lee, HW | 1 |
| Lee, SA | 1 |
| Shin, DJ | 1 |
| Kim, WJ | 1 |
| Song, HK | 1 |
| Song, K | 1 |
| Lee, BI | 1 |
| Takeoka, M | 2 |
| Riviello, JJ | 2 |
| Pfeifer, H | 1 |
| Thiele, EA | 1 |
| Perez Velazquez, JL | 1 |
| HAMILTON, RW | 1 |
| SCHOOLMAN, A | 1 |
| Leniger, T | 1 |
| Thöne, J | 1 |
| Wiemann, M | 2 |
| Garris, SS | 1 |
| Oles, KS | 1 |
| Woodbury, DM | 1 |
| Engstrom, FL | 1 |
| White, HS | 1 |
| Chen, CF | 1 |
| Kemp, JW | 1 |
| Chow, SY | 1 |
| de Manueles, J | 2 |
| Macías Núñez, JF | 1 |
| Rodríguez Commes, JL | 2 |
| Blázquez, J | 1 |
| Santos Borbujo, J | 1 |
| Salazar, V | 1 |
| Giesen, H | 1 |
| Tabernero Romo, JM | 1 |
| González Macías, S | 1 |
| Bondía, A | 1 |
| Acosta, A | 1 |
| Marcías Núñez, JF | 1 |
| de Castro del Pozo, S | 1 |
| Radó, JP | 1 |
| Haris, A | 1 |
| Bonnet, U | 2 |
| Bingmann, D | 2 |
| Hazouard, E | 1 |
| Dequin, PF | 1 |
| Lanotte, R | 1 |
| Legras, A | 1 |
| Ferrandière, M | 1 |
| Perrotin, D | 1 |
| Laskey, AL | 1 |
| Korn, DE | 1 |
| Moorjani, BI | 1 |
| Patel, NC | 1 |
| Tobias, JD | 1 |
| Holmes, GL | 1 |
| Thiele, E | 1 |
| Bourgeois, BF | 1 |
| Helmers, SL | 1 |
| Duffy, FH | 1 |
| Ko, CH | 1 |
| Kong, CK | 1 |
| Blüml, S | 1 |
| Moreno-Torres, A | 1 |
| Shic, F | 1 |
| Nguy, CH | 1 |
| Ross, BD | 1 |
| Philippi, H | 1 |
| Boor, R | 1 |
| Reitter, B | 1 |
| Poli, S | 1 |
| Vincent, A | 1 |
| Perret, C | 1 |
| Siesjö, BK | 1 |
| Viukari, NM | 5 |
| Plum, F | 1 |
| Howse, DC | 1 |
| Duffy, TE | 1 |
| Meldrum, BS | 1 |
| Horton, RW | 1 |
| Matti, N | 1 |
| Viukari, A | 1 |
| Tammisto, P | 3 |
| Benn, A | 1 |
| Swan, CH | 1 |
| Cooke, WT | 1 |
| Blair, JA | 1 |
| Matty, AJ | 1 |
| Smith, ME | 1 |
2 reviews available for hydrogen carbonate and Aura
| Article | Year |
|---|---|
[Lactic acidosis].
Topics: Acidosis; Bicarbonates; Biguanides; Diabetes Mellitus; Epilepsy; Ethanol; Fructose; Heart Failure; H | 1985 |
Acid-base homeostasis in the brain: physiology, chemistry, and neurochemical pathology.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Bicarbonates; Brain; Brain Damage, Chronic; Brain Ischemia | 1985 |
1 trial available for hydrogen carbonate and Aura
| Article | Year |
|---|---|
The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Bicarbonates; Bone and Bones; Bone Density; Calcificat | 2011 |
31 other studies available for hydrogen carbonate and Aura
| Article | Year |
|---|---|
Distal renal tubular acidosis and lethargy associated with zonisamide treatment in a dog with idiopathic epilepsy.
Topics: Acidosis, Renal Tubular; Animals; Bicarbonates; Dog Diseases; Dogs; Epilepsy; Lethargy; Male; Zonisa | 2022 |
Anion gap can differentiate between psychogenic and epileptic seizures in the emergency setting.
Topics: Acid-Base Equilibrium; Adult; Bicarbonates; Electroencephalography; Emergency Service, Hospital; Epi | 2017 |
Chronic impact of topiramate on acid-base balance and potassium in childhood.
Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Anticonvulsants; Bicarbonates; Child; Child, Preschool; | 2010 |
The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus.
Topics: Animals; Anticonvulsants; Barium; Bicarbonates; CA1 Region, Hippocampal; Carbonic Anhydrase Inhibito | 2010 |
Concomitant treatment with topiramate and ketogenic diet in pediatric epilepsy.
Topics: Acidosis; Adolescent; Age Factors; Anticonvulsants; Bicarbonates; Child; Child, Preschool; Combined | 2002 |
Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity.
Topics: Animals; Animals, Newborn; Bicarbonates; Bicuculline; Carbonic Anhydrase Inhibitors; Disease Models, | 2003 |
ACID-BASE CHANGES IN CATS FOLLOWING EXPERIMENTAL EPILEPTIC SEIZURES.
Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Blood Chemical Analysis; Cats; Cerebellum; Electric S | 1965 |
Topiramate modulates pH of hippocampal CA3 neurons by combined effects on carbonic anhydrase and Cl-/HCO3- exchange.
Topics: Action Potentials; Ammonium Chloride; Animals; Anticonvulsants; Bicarbonates; Carbon Dioxide; Carbon | 2004 |
Impact of topiramate on serum bicarbonate concentrations in adults.
Topics: Acidosis; Adult; Aged; Aged, 80 and over; Anticonvulsants; Bicarbonates; Cohort Studies; Epilepsy; F | 2005 |
Ionic and acid-base regulation of neurons and glia during seizures.
Topics: Acid-Base Equilibrium; Adenosine Triphosphatases; Animals; Anion Transport Proteins; Bicarbonates; C | 1984 |
[Threshold for bicarbonate in epileptic children in treatment with anticonvulsant drugs (author's transl)].
Topics: Acidosis, Renal Tubular; Adolescent; Anticonvulsants; Bicarbonates; Child; Child, Preschool; Cyclic | 1981 |
[Infusion therapy in infants and small children].
Topics: Acidosis; Bicarbonates; Dehydration; Epilepsy; Fluid Therapy; Humans; Hyponatremia; Infant; Infant, | 1982 |
[A study of the urinary acidifying capacity of patients chronically treated with anticonvulsants (author's transl)].
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Bicarbonates; Calcium; Epilepsy; Female; H | 1981 |
Metabolic bone disease (anticonvulsant osteomalacia) and renal tubular acidosis in tuberous sclerosis.
Topics: Acidosis, Renal Tubular; Adult; Back Pain; Bicarbonates; Bone and Bones; Calcitriol; Calcium; Calciu | 1993 |
GABA-responses of CA3 neurones at epileptogenic threshold concentrations of convulsants.
Topics: Action Potentials; Animals; Bicarbonates; Bicuculline; Caffeine; Chlorides; Convulsants; Epilepsy; g | 1993 |
CO2/HCO3(-)-withdrawal from the bath medium of hippocampal slices: biphasic effect on intracellular pH and bioelectric activity of CA3-neurons.
Topics: Animals; Bicarbonates; Carbon Dioxide; Culture Media; Electrophysiology; Epilepsy; gamma-Aminobutyri | 1998 |
[Losing consciousness: role of the venous lactate levels in the diagnosis of convulsive crises].
Topics: Adult; Aged; Bicarbonates; Diagnosis, Differential; Emergencies; Epilepsy; Female; Humans; Hydrogen- | 1998 |
Central hyperventilation related to administration of topiramate.
Topics: Adolescent; Anticonvulsants; Bicarbonates; Chlorides; Epilepsy; Female; Fructose; Humans; Hyperventi | 2000 |
Topiramate and metabolic acidosis in pediatric epilepsy.
Topics: Acidosis; Adolescent; Adult; Age Factors; Anticonvulsants; Bicarbonates; Carbonic Anhydrase Inhibito | 2001 |
Topiramate-induced metabolic acidosis: report of two cases.
Topics: Acidosis; Anticonvulsants; Bicarbonates; Blood Gas Analysis; Child; Dose-Response Relationship, Drug | 2001 |
Tricarboxylic acid cycle of glia in the in vivo human brain.
Topics: Acetates; Adult; Bicarbonates; Brain; Carbon Isotopes; Citric Acid Cycle; Epilepsy; Female; Glutamic | 2002 |
Topiramate and metabolic acidosis in infants and toddlers.
Topics: Acid-Base Equilibrium; Acidosis; Age Factors; Anticonvulsants; Bicarbonates; Blood Gas Analysis; Chi | 2002 |
Low potassium levels in the cerebrospinal fluid of forty mentally subnormal epileptics.
Topics: Adenosine Triphosphatases; Adolescent; Adult; Bicarbonates; Chlorides; Epilepsy; Glycolysis; Humans; | 1970 |
Metabolic effects of seizures.
Topics: Acidosis; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bicarbonates; Blood Flow Velocity; | 1974 |
Physiology of status epilepticus in primates.
Topics: Alkaloids; Animals; Bicarbonates; Blood Glucose; Blood Pressure; Blood Proteins; Body Temperature; B | 1973 |
Central effects of diphenylhydantoin (dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |
Central effect of diphenylhydantoin (Dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |
Ammonium chloride as an adjuvant to diphenyl-hydantoin therapy, and bulk ions in the CSF and serum in forty mentally subnormal epileptics.
Topics: Ammonium Chloride; Bicarbonates; Calcium; Carbon Dioxide; Chlorides; Epilepsy; Humans; Intellectual | 1970 |
Effects of diphenylhydantoin, pH and total carbon dioxide in the cerebrospinal fluid during sodium bicarbonate and ammonium chloride intake in forty mentally sub-normal epileptics.
Topics: Acid-Base Equilibrium; Adolescent; Adult; Ammonium Chloride; Bicarbonates; Calcium; Carbon Dioxide; | 1970 |
Ammonium chloride as an adjuvant to diphenylhydantoin therapy, and pH, base bicarbonate and sodium in the serum of forty mentally subnormal epileptics.
Topics: Acid-Base Equilibrium; Ammonium Chloride; Bicarbonates; Chlorides; Epilepsy; Humans; Hydrogen-Ion Co | 1970 |
Effect of intraluminal pH on the absorption of pteroylmonoglutamic acid.
Topics: Bicarbonates; Epilepsy; Female; Folic Acid; Humans; Hydrogen-Ion Concentration; Intestinal Absorptio | 1971 |