Page last updated: 2024-10-18

hydrogen carbonate and Anemia

hydrogen carbonate has been researched along with Anemia in 37 studies

Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.

Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

Research Excerpts

ExcerptRelevanceReference
"We have identified a novel homozygous nonsense mutation (W516X) in the kidney-type electrogenic sodium bicarbonate cotransporter 1 (NBC1) in a patient with isolated proximal renal tubular acidosis (pRTA)."3.77Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis. ( Fujita, T; Horita, S; Lin, SH; Lin, SW; Lo, YF; Seki, G; Tsai, JD; Usui, T; Yamada, H; Yamazaki, O; Yang, SS; Yu, IS, 2011)
" Two sets of experimental data, derived from two different methods of inducing anemia, were used: repetitive doses of phenylhydrazine (PHZ) and bleeding (BL)."3.70Acid-base analysis during experimental anemia in rats. ( Alfaro, V; Palacios, L; Pesquero, J, 2000)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199020 (54.05)18.7374
1990's8 (21.62)18.2507
2000's1 (2.70)29.6817
2010's7 (18.92)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Meremo, A1
Paget, G1
Duarte, R1
Dickens, C1
Dix-Peek, T1
Bintabara, D1
Naicker, S1
Peng, Z1
Wang, J1
Yuan, Q1
Xiao, X1
Xu, H1
Xie, Y1
Wang, W1
Huang, L1
Zhong, Y1
Ao, X1
Zhang, L1
Zhao, M1
Tao, L1
Zhou, Q1
Maruta, Y1
Hasegawa, T1
Yamakoshi, E1
Nishiwaki, H1
Koiwa, F1
Imai, E1
Hishida, A1
Pruthi, R1
Maxwell, H1
Casula, A1
Braddon, F1
Lewis, M1
O'Brien, C1
Stojanovic, J1
Tse, Y1
Inward, C1
Sinha, MD1
Panichi, V1
Scatena, A1
Rosati, A1
Giusti, R1
Ferro, G1
Malagnino, E1
Capitanini, A1
Piluso, A1
Conti, P1
Bernabini, G1
Migliori, M1
Caiani, D1
Tetta, C1
Casani, A1
Betti, G1
Pizzarelli, F1
Chase, HS1
Hirsch, JS1
Mohan, S1
Rao, MK1
Radhakrishnan, J1
Djuric, PS1
Jankovic, A1
Popovic, J1
Tosic Dragovic, J1
Bulatovic, A1
Djuric, Z1
Mitrovic, M1
Dimkovic, N1
Lo, YF1
Yang, SS1
Seki, G1
Yamada, H1
Horita, S1
Yamazaki, O1
Fujita, T1
Usui, T1
Tsai, JD1
Yu, IS1
Lin, SW1
Lin, SH1
APTHORP, GH1
MEASDAY, B1
LEHMANN, H1
SCHWARTZ, E1
MCELFRESH, AE1
SCHREINER, GE1
BARRERAS, L1
DIGGS, LW1
FINNEY, RA1
HATCH, FE1
Andriessen, P1
Kollée, LA1
van Dijk, BA1
Lewis, NP1
Macdougall, IC1
Willis, N1
Coles, GA1
Williams, JD1
Henderson, AH1
Siggaard-Andersen, O1
Fogh-Andersen, N1
Wühl, E1
Haffner, D1
Nissel, R1
Schaefer, F1
Mehls, O1
Ifudu, O1
Dawood, M1
Homel, P1
Friedman, EA1
Wiecek, A1
Franek, E1
Kokot, F1
Rudka, R1
Mazouz, H1
Kacso, I1
Ghazali, A1
El Esper, N1
Moriniere, P1
Makdassi, R1
Hardy, P1
Westeel, PF1
Achard, JM1
Pruna, A1
Fournier, A1
Pesquero, J1
Alfaro, V1
Palacios, L1
Yamada, T1
Meldon, JH1
Garby, L1
Fuchs, D1
Hermann, J1
Zintl, F1
Plenert, W1
Wagstaff, KE1
Woodhouse, CR1
Rose, GA1
Duffy, PG1
Ransley, PG1
Pootrakul, P1
Yansukon, P1
Thongmee, A1
Finch, CA1
Lichtman, MA1
Miller, DR1
Freeman, RB1
Ninness, JR1
Kimber, RW1
McDonald, JW1
Gollan, F2
Aono, M1
McDermott, J1
Dugger, A1
Musil, G1
Lieberman, E1
Gulyi, MF1
Mikhailovskaia, LM1
Zhurbin, GI1
Gruzova, LM1
Stognii, NA1
Oliva, PB1
Marver, D1
Gurney, CW1
Tatibana, M1
Ito, K1
Moore, WE1
Otto, W1
Binder, E1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Chinese Cohort Study of Chronic Kidney Disease[NCT03041987]5,000 participants (Anticipated)Observational2012-01-01Active, not recruiting
Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933]Phase 234 participants (Actual)Interventional2019-06-18Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Diastolic Blood Pressure

(NCT03923933)
Timeframe: Change from Basal to day 28

InterventionmmHg (Mean)
Placebo-3.4
Treatment Grup-13.5

Change in Extracellular Water

Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Interventionlitres (Mean)
Placebo-0.15
Treatment Grup2.55

Change in Extracellular Water / Total Body Water Ratio

Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Interventionpercentage of ECW/TBW (Mean)
Placebo-0.24
Treatment Grup-2.92

Change in Mean Arterial Pressure

decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28

InterventionmmHg (Mean)
Placebo-5.4
Treatment Grup-18.1

Change in Systolic Blood Pressure

(NCT03923933)
Timeframe: Change from Basal to day 28

InterventionmmHg (Mean)
Placebo-10
Treatment Grup-26.1

Change in the Fractional Excretion of Sodium

Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28

Interventionpercentage of sodium excreted (Mean)
Placebo-0.348
Treatment Grup0.598

Change in Total Body Water

Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28

Interventionlitres (Mean)
Placebo-0.075
Treatment Grup-4.36

Reviews

2 reviews available for hydrogen carbonate and Anemia

ArticleYear
[Studies on extracorporeal circulation with large volume hemodilution using lactate ringer's solution and low molecular weight dextran: alterations of acid-base balance associated with intentional hemodilution (author's transl)].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1975, Volume: 50, Issue:2

    Topics: Acid-Base Equilibrium; Acidosis; Anemia; Animals; Bicarbonates; Blood Volume; Dextrans; Dogs; Electr

1975
Lactic acidosis.
    The American journal of medicine, 1970, Volume: 48, Issue:2

    Topics: Acidosis; Alcoholic Intoxication; Anemia; Animals; Bicarbonates; Cardiac Output; Diabetes Mellitus;

1970

Trials

2 trials available for hydrogen carbonate and Anemia

ArticleYear
High-volume online haemodiafiltration improves erythropoiesis-stimulating agent (ESA) resistance in comparison with low-flux bicarbonate dialysis: results of the REDERT study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2015, Volume: 30, Issue:4

    Topics: Aged; Anemia; Bicarbonates; C-Reactive Protein; Cross-Over Studies; Drug Resistance; Erythropoiesis;

2015
Short dialyzed children respond less to growth hormone than patients prior to dialysis. German Study Group for Growth Hormone Treatment in Chronic Renal Failure.
    Pediatric nephrology (Berlin, Germany), 1996, Volume: 10, Issue:3

    Topics: Acidosis; Anemia; Anthropometry; Bicarbonates; Buffers; Child; Female; Glomerular Filtration Rate; G

1996

Other Studies

33 other studies available for hydrogen carbonate and Anemia

ArticleYear
Demographic and clinical profile of black patients with chronic kidney disease attending a tertiary hospital in Johannesburg, South Africa.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Acidosis; Aged; Allopurinol; Anemia; Bicarbonates; Cross-Sectional Studies; Diabetes Mellitus; Doxaz

2022
Clinical features and CKD-related quality of life in patients with CKD G3a and CKD G3b in China: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE).
    BMC nephrology, 2017, Oct-13, Volume: 18, Issue:1

    Topics: Adult; Anemia; Bicarbonates; Blood Pressure; China; Cholesterol, HDL; Cost of Illness; Female; Glome

2017
Association between serum Na-Cl level and renal function decline in chronic kidney disease: results from the chronic kidney disease Japan cohort (CKD-JAC) study.
    Clinical and experimental nephrology, 2019, Volume: 23, Issue:2

    Topics: Acidosis; Aged; Anemia; Bicarbonates; Biomarkers; Disease Progression; Down-Regulation; Female; Glom

2019
UK Renal Registry 16th annual report: chapter 13 clinical, haematological and biochemical parameters in patients receiving renal replacement therapy in paediatric centres in the uk in 2012: national and centre-specific analyses.
    Nephron. Clinical practice, 2013, Volume: 125, Issue:1-4

    Topics: Adolescent; Anemia; Annual Reports as Topic; Bicarbonates; Blood Pressure; Body Height; Body Mass In

2013
Presence of early CKD-related metabolic complications predict progression of stage 3 CKD: a case-controlled study.
    BMC nephrology, 2014, Nov-27, Volume: 15

    Topics: Acidosis; Aged; Aged, 80 and over; Anemia; Bicarbonates; Calcium; Case-Control Studies; Creatine; Di

2014
Survival Benefit of Hemodiafiltration Compared With Prolonged High-flux Hemodialysis.
    Iranian journal of kidney diseases, 2016, Volume: 10, Issue:6

    Topics: Aged; Anemia; Bicarbonates; Calcium; Cardiovascular Diseases; Cause of Death; Erythropoietin; Female

2016
Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis.
    Kidney international, 2011, Volume: 79, Issue:7

    Topics: Acidosis; Acidosis, Renal Tubular; Age Factors; Aging; Analysis of Variance; Anemia; Animals; Aquapo

2011
Pregnancy in sickle-cell anaemia.
    Lancet (London, England), 1963, Jun-22, Volume: 1, Issue:7295

    Topics: Anemia; Anemia, Sickle Cell; Bicarbonates; Female; Humans; Pregnancy; Pregnancy Complications

1963
TREATMENT OF PAINFUL CRISES OF SICKLE CELL DISEASE. A DOUBLE BLIND STUDY.
    The Journal of pediatrics, 1964, Volume: 64

    Topics: Anemia; Anemia, Sickle Cell; Bicarbonates; Child; Double-Blind Method; Erythrocytes, Abnormal; Human

1964
TREATMENT OF CHRONIC RENAL FAILURE.
    Modern treatment, 1964, Volume: 1

    Topics: Acidosis; Anemia; Anti-Bacterial Agents; Bicarbonates; Chloramphenicol; Classification; Diet; Diet T

1964
BICARBONATES, PH AND PERCENTAGE OF SICKLED CELLS IN VENOUS BLOOD OF PATIENTS IN SICKLE CELL CRISIS.
    The American journal of the medical sciences, 1964, Volume: 247

    Topics: Anemia; Anemia, Sickle Cell; Bicarbonates; Blood; Erythrocyte Count; Hemoglobins; Hemoglobins, Abnor

1964
EFFECT OF A CARBONIC ANHYDRASE INHIBITOR (DICHLORPHENAMIDE) ON SICKLE CELL ANEMIA.
    The American journal of the medical sciences, 1965, Volume: 250

    Topics: Acidosis; Anemia; Anemia, Sickle Cell; Bicarbonates; Carbonic Anhydrase Inhibitors; Dichlorphenamide

1965
[Effect of age of erythrocyte concentration administered to premature infants: a retrospective study].
    Tijdschrift voor kindergeneeskunde, 1993, Volume: 61, Issue:3

    Topics: Anemia; Bicarbonates; Erythrocyte Aging; Erythrocyte Transfusion; Hemoglobins; Humans; Infant, Newbo

1993
Effects of the correction of renal anaemia by erythropoietin on physiological changes during exercise.
    European journal of clinical investigation, 1993, Volume: 23, Issue:7

    Topics: Adolescent; Adult; Aged; Anemia; Bicarbonates; Erythropoietin; Exercise Tolerance; Female; Humans; K

1993
Base excess or buffer base (strong ion difference) as measure of a non-respiratory acid-base disturbance.
    Acta anaesthesiologica Scandinavica. Supplementum, 1995, Volume: 107

    Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis; Alkalosis; Anemia; Bicarbonates; Blood Gas Ana

1995
Excess morbidity in patients starting uremia therapy without prior care by a nephrologist.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 28, Issue:6

    Topics: Anemia; Bicarbonates; Blood Urea Nitrogen; Catheters, Indwelling; Creatinine; Female; Humans; Insura

1996
Influence of acetate and bicarbonate hemodialysis on the plasma erythropoietin concentration in patients with chronic renal failure.
    The International journal of artificial organs, 1997, Volume: 20, Issue:2

    Topics: Acetates; Adult; Anemia; Bicarbonates; Biocompatible Materials; Blood Gas Analysis; Cellulose; Dialy

1997
Risk factors of renal failure progression two years prior to dialysis.
    Clinical nephrology, 1999, Volume: 51, Issue:6

    Topics: Anemia; Bicarbonates; Blood Proteins; Calcium; Cholesterol; Creatinine; Diabetic Nephropathies; Dise

1999
Acid-base analysis during experimental anemia in rats.
    Canadian journal of physiology and pharmacology, 2000, Volume: 78, Issue:10

    Topics: Acid-Base Imbalance; Alkalosis, Respiratory; Anemia; Animals; Bicarbonates; Carbon Dioxide; Erythroc

2000
A theoretical model of the respiratory function of blood.
    Advances in experimental medicine and biology, 1976, Volume: 75

    Topics: Anemia; Bicarbonates; Blood Flow Velocity; Carbon Dioxide; Chlorides; Diphosphoglyceric Acids; Hydro

1976
[Basic therapy in children with leukemia and a malignant tumors. II].
    Kinderarztliche Praxis, 1978, Volume: 46, Issue:3

    Topics: Allopurinol; Anaphylaxis; Anemia; Antibiotics, Antineoplastic; Bicarbonates; Blood Transfusion; Chil

1978
Blood and urine analysis in patients with intestinal bladders.
    British journal of urology, 1991, Volume: 68, Issue:3

    Topics: Adolescent; Anemia; Bacteriuria; Bicarbonates; Body Height; Child; Child, Preschool; Chlorides; Foli

1991
A mild uncompensated alkalosis in anemia.
    The American journal of the medical sciences, 1987, Volume: 294, Issue:6

    Topics: Adolescent; Adult; Alkalosis; Anemia; Anemia, Aplastic; Anemia, Hypochromic; Bicarbonates; Carbon Di

1987
Erythrocyte adenosine triphosphate depletion during hypophosphatemia in a uremic subject.
    The New England journal of medicine, 1969, Jan-30, Volume: 280, Issue:5

    Topics: Acidosis; Adenosine Triphosphatases; Adenosine Triphosphate; Adult; Aluminum; Anemia; Antacids; Bica

1969
Erythrocyte 2,3-DPG, ATP and oxygen affinity in hemodialysis patients.
    Canadian Medical Association journal, 1974, Oct-05, Volume: 111, Issue:7

    Topics: Adenosine Triphosphate; Administration, Oral; Adult; Aluminum Hydroxide; Anemia; Bicarbonates; Dipho

1974
The effect of temperature on asanguineous rabbits.
    Cryobiology, 1973, Volume: 10, Issue:4

    Topics: Anemia; Animals; Bicarbonates; Blood Pressure; Blood Viscosity; Body Temperature; Carbon Dioxide; Ca

1973
Experimental study of perfusion of rabbits with fluorocarbon fluid in the acute asanguineous state.
    Resuscitation, 1972, Volume: 1, Issue:3

    Topics: Acute Disease; Anemia; Animals; Bicarbonates; Blood Pressure; Blood Volume; Body Temperature; Carbon

1972
Management of acute renal failure in infants and children.
    Nephron, 1973, Volume: 11, Issue:2

    Topics: Acidosis; Acute Kidney Injury; Anemia; Bicarbonates; Calcium; Child, Preschool; Dehydration; Furosem

1973
[CO2 fixation (carboxylation) and blood regeneration in rabbits with experimental posthemorrhagic anemia].
    Voprosy meditsinskoi khimii, 1973, Volume: 19, Issue:6

    Topics: Acid-Base Equilibrium; Anemia; Animals; Bicarbonates; Blood Proteins; Bone Marrow; Carbon Dioxide; E

1973
Renal erythropoietin excretion as a function of acid base balance.
    Annals of the New York Academy of Sciences, 1968, Mar-29, Volume: 149, Issue:1

    Topics: Acid-Base Equilibrium; Adolescent; Anemia; Anemia, Aplastic; Animals; Bicarbonates; Biological Assay

1968
Control of pyrimidine biosynthesis in mammalian tissues. I. Partial purification and characterization of glutamine-utilizing carbamyl phosphate synthetase of mouse spleen and its tissue distribution.
    The Journal of biological chemistry, 1969, Oct-10, Volume: 244, Issue:19

    Topics: Adenosine Triphosphate; Anemia; Animals; Anura; Bicarbonates; Carbamates; Carbon Isotopes; Cattle; C

1969
Metabolic acidosis in bovine erythropoietic porphyria during the neonatal period.
    American journal of veterinary research, 1970, Volume: 31, Issue:9

    Topics: Acid-Base Equilibrium; Acidosis; Anemia; Animals; Animals, Newborn; Bicarbonates; Blood Cell Count;

1970
[Clinical aspects of chronic gout].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1966, Sep-15, Volume: 21, Issue:18

    Topics: Adult; Aged; Allopurinol; Anemia; Arthritis; Bicarbonates; Blood Sedimentation; Chronic Disease; Fem

1966