hydrogen carbonate has been researched along with Alloxan Diabetes in 53 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metabolic alkalosis was induced in starved mice by treatment with NaHCO3, which did not significantly alter the blood glucose concentration, but protected against the diabetogenic effect of subsequently given alloxan." | 7.66 | Effect of metabolic alkalosis on the B-cell sensitivity to alloxan in vivo. ( Boquist, L, 1978) |
| "Metabolic alkalosis was induced in starved mice by treatment with NaHCO3, which did not significantly alter the blood glucose concentration, but protected against the diabetogenic effect of subsequently given alloxan." | 3.66 | Effect of metabolic alkalosis on the B-cell sensitivity to alloxan in vivo. ( Boquist, L, 1978) |
| "Cerebral edema in diabetic ketoacidosis (DKA-CE) occurs primarily in children and can develop during DKA therapy." | 1.34 | Combined insulin and bicarbonate therapy elicits cerebral edema in a juvenile mouse model of diabetic ketoacidosis. ( Fraser, DD; Pin, CL; Rose, KL; Wang, R, 2007) |
| "Diarrhea was noted in rats with streptozocin-induced chronic diabetes." | 1.27 | Diarrhea in streptozocin-treated rats. Loss of adrenergic regulation of intestinal fluid and electrolyte transport. ( Bergenstal, RM; Chang, EB; Field, M, 1985) |
| "It is concluded that NaHCO3 therapy in diabetic ketoacidosis decreases the cerebral O2 availability and that cerebral hypoxia contributes to the brain dysfunction encountered after the initiation of such therapy in acidemia." | 1.26 | Cerebral hypoxia from bicarbonate infusion in diabetic acidosis. ( Bégin, R; Berthiaume, Y; Bureau, MA; Gagnon, N; Khoury, K; Shapcott, D, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (69.81) | 18.7374 |
| 1990's | 7 (13.21) | 18.2507 |
| 2000's | 6 (11.32) | 29.6817 |
| 2010's | 3 (5.66) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ekperikpe, US | 1 |
| Owolabi, OJ | 1 |
| Olapeju, BI | 1 |
| Adewoye, EO | 1 |
| Ige, AO | 1 |
| Prat, ML | 1 |
| López-Gonzálvez, A | 1 |
| Ruiz, MA | 1 |
| Barbas, C | 1 |
| Futakuchi, S | 1 |
| Ishiguro, H | 1 |
| Naruse, S | 1 |
| Ko, SB | 1 |
| Fujiki, K | 1 |
| Yamamoto, A | 1 |
| Nakakuki, M | 1 |
| Song, Y | 1 |
| Steward, MC | 1 |
| Kondo, T | 1 |
| Goto, H | 1 |
| Laustsen, C | 1 |
| Østergaard, JA | 1 |
| Lauritzen, MH | 1 |
| Nørregaard, R | 1 |
| Bowen, S | 1 |
| Søgaard, LV | 1 |
| Flyvbjerg, A | 1 |
| Pedersen, M | 1 |
| Ardenkjaer-Larsen, JH | 1 |
| FROHMAN, CE | 1 |
| ORTEN, JM | 1 |
| HAUGAARD, ES | 1 |
| HAUGAARD, N | 1 |
| Ramakrishnan, R | 1 |
| Prabhakaran, K | 1 |
| Jayakumar, AR | 1 |
| Gunasekaran, P | 1 |
| Sheeladevi, R | 1 |
| Suthanthirarajan, N | 1 |
| Rose, KL | 1 |
| Pin, CL | 1 |
| Wang, R | 1 |
| Fraser, DD | 1 |
| Hermansen, K | 1 |
| Arieff, AI | 2 |
| Leach, W | 1 |
| Park, R | 1 |
| Lazarowitz, VC | 1 |
| Dodi, G | 1 |
| Militello, C | 1 |
| Pedrazzoli, S | 1 |
| Zannini, G | 1 |
| Lise, M | 1 |
| Hutson, JC | 1 |
| Hern, EP | 1 |
| Varandani, PT | 1 |
| Bureau, MA | 1 |
| Bégin, R | 1 |
| Berthiaume, Y | 1 |
| Shapcott, D | 1 |
| Khoury, K | 1 |
| Gagnon, N | 1 |
| Bond, JS | 1 |
| Reach, G | 1 |
| Poussier, P | 1 |
| Sausse, A | 1 |
| Assan, R | 1 |
| Itoh, M | 1 |
| Gerich, JE | 1 |
| Hetenyi, G | 1 |
| Khandoudi, N | 1 |
| Bernard, M | 1 |
| Cozzone, P | 1 |
| Feuvray, D | 2 |
| Takehara, K | 2 |
| Tashima, K | 2 |
| Takeuchi, K | 2 |
| Kato, S | 1 |
| Le Prigent, K | 1 |
| Lagadic-Gossmann, D | 1 |
| Mongodin, E | 1 |
| Kusuoka, H | 1 |
| Matsuda, S | 1 |
| Ishikawa, M | 1 |
| Koga, K | 1 |
| Mori, T | 1 |
| Yamaguchi, H | 1 |
| Nishimura, T | 1 |
| Levine, DZ | 1 |
| Iacovitti, M | 1 |
| Burns, KD | 1 |
| Goralski, KB | 1 |
| Stupack, DG | 1 |
| Hatch, GM | 1 |
| Sitar, DS | 1 |
| Kerian, A | 1 |
| Boquist, L | 2 |
| López-Moratalla, N | 1 |
| Franch, V | 1 |
| Paniagua, R | 1 |
| Santiago, E | 1 |
| Iynedjian, PB | 1 |
| Ballard, FJ | 1 |
| Hanson, RW | 1 |
| Okajima, F | 1 |
| Ui, M | 1 |
| Beech, JS | 1 |
| Williams, SC | 1 |
| Cohen, RD | 1 |
| Iles, RA | 1 |
| Bank, N | 2 |
| Aynedjian, HS | 2 |
| Källén, R | 1 |
| Borgström, A | 1 |
| Fält, K | 1 |
| Mapes, RE | 1 |
| Watford, M | 1 |
| Chang, EB | 1 |
| Bergenstal, RM | 1 |
| Field, M | 1 |
| Lahorra, MA | 1 |
| Williams, ME | 1 |
| Spokes, K | 1 |
| Silva, P | 1 |
| Numa, S | 1 |
| Hashimoto, T | 1 |
| Nakanishi, S | 1 |
| Okazaki, T | 1 |
| Buniatian, GK | 1 |
| Egian, VB | 1 |
| Turshian, GA | 1 |
| Akopian, GE | 1 |
| Safrazian, SS | 1 |
| L'Age, M | 1 |
| Fechner, W | 1 |
| Langholz, J | 1 |
| Salzmann, H | 1 |
| Sitt, R | 1 |
| Senft, G | 1 |
| Losert, W | 1 |
| Bartelheimer, HK | 1 |
| Nordlie, RC | 1 |
| Benke, A | 2 |
| Suki, WN | 1 |
| Herbert, CS | 1 |
| Stinebaugh, BJ | 1 |
| Martinez-Maldonado, M | 1 |
| Eknoyan, G | 1 |
| Hohenegger, M | 1 |
| Rudas, B | 1 |
| Shimizu, S | 2 |
| Brech, W | 1 |
| Shrago, E | 1 |
| Wilken, D | 1 |
| Johnson, DC | 1 |
| Ebert, KA | 1 |
| Ray, PD | 1 |
| Mehlman, MA | 1 |
| Tobin, RB | 1 |
| Johnston, JB | 1 |
| Cahill, GF | 1 |
| Tiscornia, OM | 1 |
| Janowitz, HD | 1 |
| Dreiling, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double Blind, Placebo Controlled, Cross Over Study to Investigate the Effectiveness and Safety of Eluxadoline in the Treatment of Diabetic Diarrhea[NCT04313088] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2022-07-01 | Withdrawn (stopped due to This study did not enroll any subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
53 other studies available for hydrogen carbonate and Alloxan Diabetes
| Article | Year |
|---|---|
Effects of Parkia biglobosa aqueous seed extract on some biochemical, haematological and histopathological parameters in streptozotocin induced diabetic rats.
Topics: Animals; Bicarbonates; Chlorides; Diabetes Mellitus, Experimental; Erythrocytes; Fabaceae; Female; K | 2019 |
Lipid Profile and Electrolyte Composition in Diabetic Rats Treated With Leaf Extract of Musa sapientum.
Topics: Animals; Bicarbonates; Calcium; Chlorides; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes | 2016 |
Ultrasound-assisted extraction for rapid determination of Zn, Cu, Fe, Mg and Mn in liver of diabetic rats under different antioxidant treatments.
Topics: Acids; Animals; Antioxidants; Ascorbic Acid; Bicarbonates; Buffers; Cattle; Chlorophyta; Diabetes Me | 2009 |
High glucose inhibits HCO3(-) and fluid secretion in rat pancreatic ducts.
Topics: Animals; Bicarbonates; Diabetes Mellitus, Experimental; Glucose; Male; Membrane Potentials; Pancreat | 2009 |
Assessment of early diabetic renal changes with hyperpolarized [1-(13) C]pyruvate.
Topics: Animals; Bicarbonates; Carbon Isotopes; Diabetes Mellitus, Experimental; Female; Kidney; L-Lactate D | 2013 |
Tracer studies of acids of the tricarboxylic acid cycle. II. Effect of fructose and bicarbonate on acetate metabolism in livers of diabetic rats.
Topics: Acetates; Acids; Animals; Bicarbonates; Catabolite Repression; Citrates; Citric Acid Cycle; Diabetes | 1956 |
DIABETIC METABOLISM. II. THE EFFECT OF IONS ON GLUCOSE UTILIZATION AND HIGH ENERGY PHOSPHATE FORMATION IN HEART HOMOGENATES FROM NORMAL AND ALLOXAN-DIABETIC RATS.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alloxan; Animals; Bicarbonates; Carbohydrate Meta | 1965 |
Involvement of Ca2+/calmodulin-dependent protein kinase II in the modulation of indolamines in diabetic and hyperglycemic rats.
Topics: Acidosis; Alloxan; Ammonium Chloride; Analysis of Variance; Animals; Bicarbonates; Blood Glucose; Bl | 2005 |
Combined insulin and bicarbonate therapy elicits cerebral edema in a juvenile mouse model of diabetic ketoacidosis.
Topics: Animals; Bicarbonates; Brain Edema; Child; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; D | 2007 |
Stimulatory effect of beta-hydroxybutyrate on the release of somatostatin from the isolated pancreas of normal and streptozotocin-diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Animals; Bicarbonates; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; | 1982 |
Systemic effects of NaHCO3 in experimental lactic acidosis in dogs.
Topics: Acidosis; Animals; Bicarbonates; Blood Pressure; Cardiac Output; Diabetes Mellitus, Experimental; Do | 1982 |
Exocrine pancreatic function in diabetic rats treated with intraportal islet transplantation.
Topics: Animals; Bicarbonates; Diabetes Mellitus, Experimental; Insulin; Insulin Secretion; Islets of Langer | 1984 |
Altered biochemical responses by rat Sertoli cells and peritubular cells cultured under simulated diabetic conditions.
Topics: 3-Hydroxybutyric Acid; Androgen-Binding Protein; Animals; Bicarbonates; Carrier Proteins; Cells, Cul | 1984 |
Turnover of hepatic glutathione-insulin transhydrogenase (disulfide interchange enzyme) in normal and diabetic rats utilizing a new simplified isolation procedure.
Topics: Animals; Bicarbonates; Diabetes Mellitus, Experimental; Immunodiffusion; Liver; Male; Methods; Micro | 1980 |
Cerebral hypoxia from bicarbonate infusion in diabetic acidosis.
Topics: Acidosis; Animals; Bicarbonates; Carbon Dioxide; Cisterna Magna; Diabetes Mellitus, Experimental; Di | 1980 |
Failure to demonstrate increased protein turnover and intracellular proteinase activity in livers of mice with streptozotocin-induced diabetes.
Topics: Animals; Bicarbonates; Cytosol; Diabetes Mellitus, Experimental; Kinetics; Leucine; Liver; Male; Mic | 1980 |
Functional evaluation of a bioartificial pancreas using isolated islets perifused with blood ultrafiltrate.
Topics: Animals; Bicarbonates; Bioprosthesis; Blood; Blood Glucose; Buffers; Diabetes Mellitus, Experimental | 1981 |
Correction for the metabolic exchange of 14C for 12C atoms in the pathway of gluconeogenesis in vivo.
Topics: Alanine; Animals; Bicarbonates; Blood Glucose; Carbon; Carbon Radioisotopes; Citric Acid Cycle; Diab | 1982 |
Mechanisms of intracellular pH regulation during postischemic reperfusion of diabetic rat hearts.
Topics: Amiloride; Animals; Bicarbonates; Diabetes Mellitus, Experimental; HEPES; Hydrogen-Ion Concentration | 1995 |
Alterations in duodenal bicarbonate secretion and mucosal susceptibility to acid in diabetic rats.
Topics: Animals; Bicarbonates; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Resistance; | 1997 |
Failure of the nitric oxide synthase inhibitor to stimulate duodenal bicarbonate secretion in streptozotocin-diabetic rats.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Ulcer Agents; Bicarbonates; Blood Glucose; Blood Press | 1997 |
HCO3(-)-dependent alkalinizing transporter in adult rat ventricular myocytes: characterization and modulation.
Topics: Amiloride; Animals; Bicarbonates; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calci | 1997 |
Difference in the mechanisms for compensating ischemic acidosis in diabetic rat hearts.
Topics: Acidosis; Animals; Bicarbonates; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Myocard | 1998 |
Distal tubule bicarbonate reabsorption in intact and remnant diabetic kidneys.
Topics: Absorption; Acid-Base Equilibrium; Acidosis; Aldosterone; Animals; Bicarbonates; Biological Transpor | 2000 |
Perturbation of rat renal tubule transport of the organic cation amantadine in recent onset streptozotocin-induced diabetes and in uninephrectomy.
Topics: Amantadine; Animals; Bicarbonates; Carrier Proteins; Diabetes Mellitus, Experimental; Dopamine Agent | 2001 |
Lactic acidosis: an experimental model.
Topics: Acidosis; Animals; Bicarbonates; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Disease Mod | 1976 |
Effect of metabolic alkalosis on the B-cell sensitivity to alloxan in vivo.
Topics: Alkalosis; Alloxan; Animals; Bicarbonates; Blood Glucose; Carbon Dioxide; Diabetes Mellitus, Experim | 1978 |
Changes in bicarbonate stimulation of rat liver mitochondrial ATPase under different metabolic situations.
Topics: Adenosine Triphosphatases; Animals; Bicarbonates; Cold Temperature; Diabetes Mellitus, Experimental; | 1977 |
The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids.
Topics: Acidosis; Adrenalectomy; Ammonium Chloride; Animals; Bicarbonates; Cyclic AMP; Cycloheximide; Cytoso | 1975 |
Metabolism of glucose in hyper- and hypo-thyroid rats in vivo. Minor role of endogenous insulin in thyroid-dependent changes in glucose turnover.
Topics: Animals; Bicarbonates; Blood Glucose; Diabetes Mellitus, Experimental; Hyperthyroidism; Hypothyroidi | 1979 |
Differences in the blood glucose response of mice to alloxan and alloxan-inhibiting compounds.
Topics: Acetazolamide; Alloxan; Animals; Bicarbonates; Blood Glucose; Deoxy Sugars; Diabetes Mellitus, Exper | 1979 |
Measurement of skeletal muscle pH using 1H and 31P NMR spectroscopy in vivo.
Topics: Animals; Bicarbonates; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Hydrogen; Hydrogen-Io | 1992 |
Progressive increases in luminal glucose stimulate proximal sodium absorption in normal and diabetic rats.
Topics: Acetates; Animals; Bicarbonates; Blood Glucose; Diabetes Mellitus, Experimental; Kidney Tubules, Pro | 1990 |
Pancreatic enzymes in serum and urine as indicators of pancreatic allograft rejection in the pig.
Topics: Amylases; Animals; Bicarbonates; Diabetes Mellitus, Experimental; Graft Rejection; Pancreas Transpla | 1989 |
Effects of metabolic acidosis and diabetes on the abundance of specific renal mRNAs.
Topics: Acidosis; Animals; Bicarbonates; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Electrophor | 1989 |
Diarrhea in streptozocin-treated rats. Loss of adrenergic regulation of intestinal fluid and electrolyte transport.
Topics: Animals; Bicarbonates; Biological Transport; Chlorides; Colon; Diabetes Mellitus, Experimental; Diar | 1985 |
Acute effect of calcium and insulin on hyperfiltration of early diabetes.
Topics: Animals; Bicarbonates; Blood Pressure; Calcium; Carbon Dioxide; Diabetes Mellitus, Experimental; Dia | 1987 |
Role of alpha-adrenergic hormones in potassium homeostasis in the rat.
Topics: Adrenalectomy; Animals; Bicarbonates; Blood Glucose; Diabetes Mellitus, Experimental; Homeostasis; H | 1987 |
Regulatory mechanisms for liver acetyl coenzyme A carboxylase.
Topics: Acetyl-CoA Carboxylase; Animals; Bicarbonates; Diabetes Mellitus, Experimental; Fasting; Kinetics; K | 1972 |
[Glutamine synthetase and glutaminase activity in the brain and liver homogenates and subcellular fractions of rats with alloxan diabetes (3)].
Topics: Animals; Aspartic Acid; Bicarbonates; Brain; Diabetes Mellitus, Experimental; Glutamate-Ammonia Liga | 1974 |
Relationship between plasma corticosterone and the development of ketoacidosis in the alloxan diabetic rat.
Topics: Adrenal Glands; Adrenalectomy; Animals; Bicarbonates; Blood; Blood Glucose; Corticosterone; Diabetes | 1974 |
[Effect of an negative potassium balance on hormonal and enzymatic regulation of carbohydrate metabolism].
Topics: Animals; Bicarbonates; Diabetes Mellitus, Experimental; Glucose-6-Phosphatase; Glycogen; Insulin; Ki | 1967 |
Some properties and possible physiological functions of phosphotransferase activities of microsomal glucose-6-phosphatase.
Topics: Alcohols; Amino Acids; Animals; Bicarbonates; Bile Acids and Salts; Carbohydrates; Citric Acid Cycle | 1969 |
[Effect of various intravenous anesthetics on glucose levels and acid-base status of the blood in alloxan diabetic rats].
Topics: Acid-Base Equilibrium; Anesthetics; Animals; Bicarbonates; Blood Glucose; Carbon Dioxide; Diabetes M | 1971 |
Effects of glucose on bicarbonate reabsorption in the dog kidney.
Topics: Analysis of Variance; Animals; Bicarbonates; Carbon Dioxide; Diabetes Mellitus, Experimental; Dogs; | 1974 |
[Behavior of serum electrolytes in alloxan diabetes in rats].
Topics: Acid-Base Equilibrium; Animals; Bicarbonates; Blood Glucose; Blood Urea Nitrogen; Chlorides; Chronic | 1971 |
[Studies on the aqueous humour dynamics of pH and P CO2 in experimental diabetic cataract of rabbit. The aqueous humour dynamics of pH in process of cataract formation].
Topics: Animals; Aqueous Humor; Bicarbonates; Carbon Dioxide; Cataract; Diabetes Mellitus, Experimental; Hyd | 1971 |
[Studies of aqueous humour dynamics in Pco2 and pH on the experimental diabetes of rabbits. On blood sugar level and cataract formation].
Topics: Animals; Aqueous Humor; Bicarbonates; Blood Glucose; Carbon Dioxide; Cataract; Diabetes Mellitus; Di | 1969 |
Studies on pyruvate carboxylase in rat and human liver.
Topics: Adipose Tissue; Animals; Aspartic Acid; Autoradiography; Bicarbonates; Carbon Isotopes; Carboxy-Lyas | 1970 |
Hepatic gluconeogenesis of the rabbit.
Topics: Animals; Aspartic Acid; Bicarbonates; Carboxy-Lyases; Citrates; Diabetes Mellitus, Experimental; Fas | 1970 |
Metabolic control of enzymes in normal, diabetic, and diabetic insulin-treated rats utilizing 1,3 butanediol.
Topics: Adipose Tissue; Animals; Aspartic Acid; Bicarbonates; Blood Glucose; Body Weight; Carbon Dioxide; Ca | 1971 |
Enzyme regulation in kidney. General discussion.
Topics: Acidosis; Alkalosis; Animals; Bicarbonates; Diabetes Mellitus, Experimental; Fasting; Gluconeogenesi | 1967 |
The effect of alloxan upon canine exocrine pancreatic secretion.
Topics: Alloxan; Amylases; Animals; Bicarbonates; Cholecystokinin; Diabetes Mellitus, Experimental; Dogs; Fe | 1968 |