hydrogen carbonate has been researched along with Airflow Obstruction, Chronic in 20 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effects of a single daily dose of acetazolamide (ACET) on metabolic alkalosis and respiratory parameters in weaning chronic obstructive pulmonary disease (COPD) patients from invasive mechanical ventilation." | 7.76 | Effectiveness of acetazolamide for reversal of metabolic alkalosis in weaning COPD patients from mechanical ventilation. ( Fagon, JY; Faisy, C; Mokline, A; Sanchez, O; Tadié, JM, 2010) |
| "Acetazolamide is commonly given to chronic obstructive pulmonary disease (COPD) patients with metabolic alkalosis." | 3.77 | Population pharmacodynamic model of bicarbonate response to acetazolamide in mechanically ventilated chronic obstructive pulmonary disease patients. ( Faisy, C; Heming, N; Urien, S, 2011) |
| "To evaluate the effects of a single daily dose of acetazolamide (ACET) on metabolic alkalosis and respiratory parameters in weaning chronic obstructive pulmonary disease (COPD) patients from invasive mechanical ventilation." | 3.76 | Effectiveness of acetazolamide for reversal of metabolic alkalosis in weaning COPD patients from mechanical ventilation. ( Fagon, JY; Faisy, C; Mokline, A; Sanchez, O; Tadié, JM, 2010) |
| "Among patients with MA and COPD or OHS, early treatment with ACTZ did not shorten significantly the duration of MV compared with placebo." | 2.84 | Effects of early administration of acetazolamide on the duration of mechanical ventilation in patients with chronic obstructive pulmonary disease or obesity-hypoventilation syndrome with metabolic alkalosis. A randomized trial. ( Heras la Calle, G; Martín Delgado, MC; Mas Serra, A; Morán Chorro, I; Raurich Puigdevall, JM; Rialp Cervera, G; Vallverdú Perapoch, I, 2017) |
| "Acetazolamide has been used for decades as a respiratory stimulant for patients with chronic obstructive pulmonary disease (COPD) and metabolic alkalosis, but no large randomized placebo-controlled trial is available to confirm this approach." | 2.82 | Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial. ( Bornstain, C; Clavel, M; Djibre, M; Duguet, A; Esvan, M; Faisy, C; Gacouin, A; Gibot, S; Heming, N; Katsahian, S; Lerolle, N; Meziani, F; Planquette, B; Rabbat, A; Ricard, JD; Ricome, JL; Sanchez, O; Schneider, F; Urien, S, 2016) |
| "Weight loss in patients with severe chronic obstructive pulmonary disease (COPD) is a prognostic bad factor." | 2.76 | [Low doses of megestrol acetate increase weight and improve nutrition status in patients with severe chronic obstructive pulmonary disease and weight loss]. ( Anguera, A; Bañuls, C; Blanquer, R; Están, N; Hernández, A; Herrejón, A; Inchaurraga, I; López, A; Palop, J, 2011) |
| "Ninety six patients (63% male) with COPD and hypercapnia above 6." | 2.73 | Normocapnia following noninvasive ventilation in acute exacerbations and chronic state of obstructive pulmonary disease. ( Bauer, JU; Gietl, C; Laier-Groeneveld, G, 2007) |
| "Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are often associated with airway fluid acidification." | 1.72 | Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model. ( Csekő, K; Draskóczi, L; Hargitai, D; Helyes, Z; Jaikumpun, P; Kerémi, B; Kéri, A; Zsembery, Á, 2022) |
| "Patients hospitalized for COPD exacerbation have an increased risk of mortality, particularly among those who fail bi-level positive airway pressure (BPAP) for hypercapnic respiratory failure subsequently requiring invasive mechanical ventilation." | 1.72 | Timing of Treatment Outcomes and Risk Factors for Failure of BPAP in Patients Hospitalized for COPD Exacerbation. ( Adagarla, BS; MacIntyre, NR; Mosher, CL; Neely, ML; Palmer, SM; Weber, JM, 2022) |
| "Nearly 25% of patients with COPD die due to cardiovascular diseases." | 1.51 | Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease. ( Arslan, S; Kaysoydu, E; Özdemir, B; Özdemir, L; Yildiz, G, 2019) |
| "Subjects with and without chronic obstructive pulmonary disease (COPD), at the beginning of weaning from mechanical ventilation." | 1.40 | Respiratory CO2 response depends on plasma bicarbonate concentration in mechanically ventilated patients. ( Ayestarán, I; Ibáñez, J; Llompart-Pou, JA; Raurich, JM; Rialp, G, 2014) |
| "We studied thirteen subjects with COPD and thirteen controls (CON)." | 1.37 | Pulmonary gas exchange during hemodialysis: a comparison of subjects with and without COPD on bicarbonate hemodialysis. ( Alfakir, M; Alhatem, E; Ali, MI; Chandran, C; Curran, RD; Debari, VA; Khan, MA; Moammar, MQ; Saoud, RM, 2011) |
| "Exacerbation of chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality, but the effect of metabolic compensation of respiratory acidosis (RA) on mortality is not fully understood." | 1.35 | Relationship of metabolic alkalosis, azotemia and morbidity in patients with chronic obstructive pulmonary disease and hypercapnia. ( Bal, C; Dagli, CE; Oztuna, F; Ucgun, I; Yildirim, H, 2008) |
| "Shock was more frequently present in the low [BE] group (46% versus 24%, P = 0." | 1.35 | Severe hyperlactatemia with normal base excess: a quantitative analysis using conventional and Stewart approaches. ( Dubin, A; Kutscherauer, DO; Masevicius, FD; Pein, MC; Tuhay, G, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Csekő, K | 1 |
| Hargitai, D | 1 |
| Draskóczi, L | 1 |
| Kéri, A | 1 |
| Jaikumpun, P | 1 |
| Kerémi, B | 1 |
| Helyes, Z | 1 |
| Zsembery, Á | 1 |
| Mosher, CL | 1 |
| Weber, JM | 1 |
| Adagarla, BS | 1 |
| Neely, ML | 1 |
| Palmer, SM | 1 |
| MacIntyre, NR | 1 |
| Aritake, H | 1 |
| Tamada, T | 1 |
| Murakami, K | 1 |
| Gamo, S | 1 |
| Nara, M | 1 |
| Kazama, I | 1 |
| Ichinose, M | 1 |
| Sugiura, H | 1 |
| Arslan, S | 1 |
| Yildiz, G | 1 |
| Özdemir, L | 1 |
| Kaysoydu, E | 1 |
| Özdemir, B | 1 |
| Rialp, G | 1 |
| Raurich, JM | 1 |
| Llompart-Pou, JA | 1 |
| Ayestarán, I | 1 |
| Ibáñez, J | 1 |
| Faisy, C | 3 |
| Meziani, F | 1 |
| Planquette, B | 1 |
| Clavel, M | 1 |
| Gacouin, A | 1 |
| Bornstain, C | 1 |
| Schneider, F | 1 |
| Duguet, A | 1 |
| Gibot, S | 1 |
| Lerolle, N | 1 |
| Ricard, JD | 1 |
| Sanchez, O | 2 |
| Djibre, M | 1 |
| Ricome, JL | 1 |
| Rabbat, A | 1 |
| Heming, N | 2 |
| Urien, S | 2 |
| Esvan, M | 1 |
| Katsahian, S | 1 |
| Raveendran, R | 1 |
| Wong, J | 1 |
| Singh, M | 1 |
| Wong, DT | 1 |
| Chung, F | 1 |
| Rialp Cervera, G | 1 |
| Raurich Puigdevall, JM | 1 |
| Morán Chorro, I | 1 |
| Martín Delgado, MC | 1 |
| Heras la Calle, G | 1 |
| Mas Serra, A | 1 |
| Vallverdú Perapoch, I | 1 |
| Manca-Di-Villahermosa, S | 1 |
| Tedesco, M | 1 |
| Lonzi, M | 1 |
| Della-Rovere, FR | 1 |
| Innocenzi, A | 1 |
| Colarieti, G | 1 |
| Favarò, A | 1 |
| Chamoun, GM | 1 |
| Taccone-Gallucci, M | 1 |
| Lim, BL | 1 |
| Kelly, AM | 1 |
| Mokline, A | 1 |
| Tadié, JM | 1 |
| Fagon, JY | 1 |
| Herrejón, A | 1 |
| Palop, J | 1 |
| Inchaurraga, I | 1 |
| López, A | 1 |
| Bañuls, C | 1 |
| Hernández, A | 1 |
| Blanquer, R | 1 |
| Están, N | 1 |
| Anguera, A | 1 |
| Prieto de Paula, JM | 1 |
| Franco Hidalgo, S | 1 |
| Borge Gallardo, L | 1 |
| Mayor Toranzo, E | 1 |
| Alfakir, M | 1 |
| Moammar, MQ | 1 |
| Ali, MI | 1 |
| Alhatem, E | 1 |
| Curran, RD | 1 |
| Saoud, RM | 1 |
| Chandran, C | 1 |
| Khan, MA | 1 |
| Debari, VA | 1 |
| Martinu, T | 1 |
| Menzies, D | 1 |
| Dial, S | 1 |
| Suwabe, A | 1 |
| Laier-Groeneveld, G | 1 |
| Gietl, C | 1 |
| Bauer, JU | 1 |
| Ucgun, I | 1 |
| Oztuna, F | 1 |
| Dagli, CE | 1 |
| Yildirim, H | 1 |
| Bal, C | 1 |
| Tuhay, G | 1 |
| Pein, MC | 1 |
| Masevicius, FD | 1 |
| Kutscherauer, DO | 1 |
| Dubin, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial to Evaluate Effectiveness of Acetazolamide in COPD Patients Developing Metabolic Alkalosis During Invasive Mechanical Ventilation[NCT01627639] | Phase 4 | 380 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Effects of Acetazolamide on the Duration of Mechanical Ventilation in Patients With Metabolic Alkalosis. Phase III Multicenter Double-blinded Clinical Trial.[NCT01499485] | Phase 3 | 140 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| Randomized Trial,Comparative With Placebo, Double Blind, to Evaluate the Effect of the Treatment With 320 mg/d of Megestrol Acetate in Patients With Severe Chronic Obstructive Pulmonary Disease (COPD) and Loss of Body Weight. Pilot Study[NCT00507949] | Phase 2 | 40 participants (Anticipated) | Interventional | 2006-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for hydrogen carbonate and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
Obesity hypoventilation syndrome, sleep apnea, overlap syndrome: perioperative management to prevent complications.
Topics: Anesthesia; Bicarbonates; Elective Surgical Procedures; Humans; Obesity Hypoventilation Syndrome; Pe | 2017 |
A meta-analysis on the utility of peripheral venous blood gas analyses in exacerbations of chronic obstructive pulmonary disease in the emergency department.
Topics: Bicarbonates; Blood Gas Analysis; Carbon Dioxide; Confidence Intervals; Disease Progression; Humans; | 2010 |
[pH, plasma HCO3- in arterial blood].
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Bicarbonates; Biomarkers; Blood Gas Analysis; Diabetes C | 2004 |
4 trials available for hydrogen carbonate and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.
Topics: Acetazolamide; Aged; Alkalosis, Respiratory; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase Inhibi | 2016 |
Effects of early administration of acetazolamide on the duration of mechanical ventilation in patients with chronic obstructive pulmonary disease or obesity-hypoventilation syndrome with metabolic alkalosis. A randomized trial.
Topics: Acetazolamide; Acidosis; Aged; Bicarbonates; Blood Gas Analysis; Double-Blind Method; Female; Follow | 2017 |
[Low doses of megestrol acetate increase weight and improve nutrition status in patients with severe chronic obstructive pulmonary disease and weight loss].
Topics: Adult; Aged; Aged, 80 and over; Appetite; Appetite Stimulants; Bicarbonates; Body Weight; Cachexia; | 2011 |
Normocapnia following noninvasive ventilation in acute exacerbations and chronic state of obstructive pulmonary disease.
Topics: Bicarbonates; Carbon Dioxide; Female; Humans; Hydrogen-Ion Concentration; Hypercapnia; Inhalation; M | 2007 |
13 other studies available for hydrogen carbonate and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model.
Topics: Animals; Bicarbonates; Cigarette Smoking; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2022 |
Timing of Treatment Outcomes and Risk Factors for Failure of BPAP in Patients Hospitalized for COPD Exacerbation.
Topics: Bicarbonates; Creatinine; Hospitalization; Humans; Hypercapnia; Noninvasive Ventilation; Pulmonary D | 2022 |
Effects of indacaterol on the LPS-evoked changes in fluid secretion rate and pH in swine tracheal membrane.
Topics: Acetylcholine; Adrenergic beta-2 Receptor Agonists; Animals; Bicarbonates; Bronchodilator Agents; Ce | 2021 |
Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease.
Topics: Aged; Bicarbonates; Blood Pressure; C-Reactive Protein; Carbon Dioxide; Case-Control Studies; Female | 2019 |
Respiratory CO2 response depends on plasma bicarbonate concentration in mechanically ventilated patients.
Topics: Aged; Bicarbonates; Carbon Dioxide; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; O | 2014 |
Acid-base balance and oxygen tension during dialysis in uremic patients with chronic obstructive pulmonary disease.
Topics: Acid-Base Equilibrium; Adult; Age Factors; Aged; Aged, 80 and over; Bicarbonates; Blood Gas Analysis | 2008 |
Effectiveness of acetazolamide for reversal of metabolic alkalosis in weaning COPD patients from mechanical ventilation.
Topics: Acetazolamide; Aged; Alkalosis; Bicarbonates; Carbonic Anhydrase Inhibitors; Case-Control Studies; F | 2010 |
Population pharmacodynamic model of bicarbonate response to acetazolamide in mechanically ventilated chronic obstructive pulmonary disease patients.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Alkalosis; Bicarbonates; Carbonic Anhydrase Inhibitor | 2011 |
The importance of identifying the association between metabolic alkalosis and respiratory acidosis.
Topics: Acetazolamide; Acidosis, Respiratory; Alkalosis; Bicarbonates; Furosemide; Humans; Obesity Hypoventi | 2012 |
Pulmonary gas exchange during hemodialysis: a comparison of subjects with and without COPD on bicarbonate hemodialysis.
Topics: Acid-Base Equilibrium; Bicarbonates; Female; Humans; Male; Middle Aged; Oxygen; Pulmonary Disease, C | 2011 |
Re-evaluation of acid-base prediction rules in patients with chronic respiratory acidosis.
Topics: Acid-Base Imbalance; Acidosis, Respiratory; Adaptation, Physiological; Adult; Aged; Bicarbonates; Bl | 2003 |
Relationship of metabolic alkalosis, azotemia and morbidity in patients with chronic obstructive pulmonary disease and hypercapnia.
Topics: Aged; Alkalosis, Respiratory; APACHE; Bicarbonates; Creatinine; Female; Humans; Hydrogen-Ion Concent | 2008 |
Severe hyperlactatemia with normal base excess: a quantitative analysis using conventional and Stewart approaches.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Bicarbonates; Blood Gas Analysis; Carbon Dioxide; Chl | 2008 |