Page last updated: 2024-10-18

hydrogen and Pancreatitis

hydrogen has been researched along with Pancreatitis in 22 studies

Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.

Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

Research Excerpts

ExcerptRelevanceReference
" Here, we evaluated the protective effects of hydrogen-rich saline on the l-arginine (l-Arg)-induced acute pancreatitis (AP)."7.76Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats. ( Cai, JM; Chen, H; Fan, LY; Li, Y; Liu, WW; Ruan, CP; Su, N; Sun, Q; Sun, XJ; Sun, YP; Wang, Q; Xiang, HG; Xu, XY; Yan, RL, 2010)
"Bentiromide test (BT) has been recently approved in the United States for screening patients with chronic pancreatitis for exocrine insufficiency."7.67Comparison of bentiromide test and rice flour breath hydrogen test in the detection of exocrine pancreatic insufficiency. ( Agarwal, N; GeeVarghese, PJ; Jain, NK; Patel, VP; Pitchumoni, CS, 1986)
"Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS)."6.72Recent advances in studies of molecular hydrogen in the treatment of pancreatitis. ( Li, G; Li, Y; Suo, L; Zhang, J, 2021)
"The hydrogen breath test was performed 7 d after AP onset to detect hydrogen production and evaluate the development of SIBO."5.46Association between acute pancreatitis and small intestinal bacterial overgrowth assessed by hydrogen breath test. ( He, F; Li, BY; Li, XC; Zhang, M; Zhu, HM, 2017)
" Here, we evaluated the protective effects of hydrogen-rich saline on the l-arginine (l-Arg)-induced acute pancreatitis (AP)."3.76Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats. ( Cai, JM; Chen, H; Fan, LY; Li, Y; Liu, WW; Ruan, CP; Su, N; Sun, Q; Sun, XJ; Sun, YP; Wang, Q; Xiang, HG; Xu, XY; Yan, RL, 2010)
"Bentiromide test (BT) has been recently approved in the United States for screening patients with chronic pancreatitis for exocrine insufficiency."3.67Comparison of bentiromide test and rice flour breath hydrogen test in the detection of exocrine pancreatic insufficiency. ( Agarwal, N; GeeVarghese, PJ; Jain, NK; Patel, VP; Pitchumoni, CS, 1986)
"Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS)."2.72Recent advances in studies of molecular hydrogen in the treatment of pancreatitis. ( Li, G; Li, Y; Suo, L; Zhang, J, 2021)
"Hydrogen sulfide displays a dual role in the mechanism of AP according to its concentration in the system."2.50From nitric oxide to hyperbaric oxygen: invisible and subtle but nonnegligible gaseous signaling molecules in acute pancreatitis. ( Dong, DL; Iv, JC; Li, L; Sun, B; Wang, G; Wu, LF, 2014)
"On univariate analysis, only the MPD stenosis was extracted as an independent factor (P = 0."1.48Increase in breath hydrogen concentration was correlated with the main pancreatic duct stenosis. ( Funasaka, K; Furukawa, K; Goto, H; Hirooka, Y; Iida, T; Ishigami, M; Ishikawa, T; Kawashima, H; Koya, T; Matsushita, M; Miyahara, R; Nakamura, M; Nishio, R; Ohno, E; Sakai, D; Shin, W; Suhara, H; Suzuki, H; Takeyama, T; Tanaka, H; Tsuruta, A; Uetsuki, K; Watanabe, O; Yamamura, T, 2018)
"The hydrogen breath test was performed 7 d after AP onset to detect hydrogen production and evaluate the development of SIBO."1.46Association between acute pancreatitis and small intestinal bacterial overgrowth assessed by hydrogen breath test. ( He, F; Li, BY; Li, XC; Zhang, M; Zhu, HM, 2017)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19905 (22.73)18.7374
1990's4 (18.18)18.2507
2000's2 (9.09)29.6817
2010's8 (36.36)24.3611
2020's3 (13.64)2.80

Authors

AuthorsStudies
Kim, DB1
Paik, CN1
Lee, JM1
Kim, YJ1
Li, Y2
Li, G1
Suo, L1
Zhang, J1
Li, K1
Yin, H1
Duan, Y1
Lai, P1
Cai, Y1
Wei, Y1
Zhang, M1
Zhu, HM1
He, F1
Li, BY1
Li, XC1
Sakai, D1
Hirooka, Y1
Kawashima, H1
Ohno, E1
Ishikawa, T1
Suhara, H1
Takeyama, T1
Koya, T1
Tanaka, H1
Iida, T1
Nishio, R1
Suzuki, H1
Uetsuki, K1
Matsushita, M1
Yamamura, T1
Furukawa, K1
Funasaka, K1
Nakamura, M1
Miyahara, R1
Watanabe, O1
Ishigami, M1
Tsuruta, A1
Shin, W1
Goto, H1
Wang, G2
Iv, JC1
Wu, LF1
Li, L1
Dong, DL1
Sun, B3
Shi, Q1
Liao, KS1
Zhao, KL1
Wang, WX1
Zuo, T1
Deng, WH1
Chen, C1
Yu, J1
Guo, WY1
He, XB1
Abliz, A1
Wang, P1
Zhao, L1
Han, B2
Zhou, H1
Jia, G2
Wang, Y1
Song, Z1
Pan, S1
Bai, X1
Lv, J1
Zhou, HX1
Hou, LM1
An, TT1
Cheng, ZX1
Ma, Y1
Zhou, YN1
Kong, R1
Wang, SJ1
Wang, YW1
Sun, XJ2
Pan, SH1
Chen, H1
Sun, YP1
Liu, WW1
Xiang, HG1
Fan, LY1
Sun, Q1
Xu, XY1
Cai, JM1
Ruan, CP1
Su, N1
Yan, RL1
Wang, Q1
Stormon, MO1
Ip, WF1
Ellis, L1
Schibli, S1
Rommens, JM1
Durie, PR1
Casellas, F1
Guarner, L1
Antolín, M1
Malagelada, JR1
Ashley, SW2
Sherman, S2
Reber, HA2
Machens, HG1
Senninger, N1
Runkel, N1
Frank, G1
von Kummer, R1
Herfarth, C1
Liu, X1
Nakano, I1
Ito, T1
Goto, M1
Migita, Y1
Furukawa, M1
Nawata, H1
Lewis, MP1
Lo, SK1
Reber, PU1
Patel, A1
Gloor, B1
Todd, KE1
Toyama, MT1
Nagata, K1
Watanabe, Y1
Adachi, J1
Watanabe, M1
Nohara, A1
Lembcke, B1
Bornholdt, C1
Kirchhoff, S1
Lankisch, PG1
Kushnir, T1
Kaplan, O1
Askenasy, N1
Navon, G1
Patel, VP1
Jain, NK1
Agarwal, N1
GeeVarghese, PJ1
Pitchumoni, CS1
Armbrecht, U1
Svanvik, J1
Ottenjann, R1
Rösch, W1
Deyhle, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Use of Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers[NCT01452217]Phase 112 participants (Actual)Interventional2010-09-30Completed
Study to Assess Pancreatic Blood Flow at Rest and During Stimulation Using Magnetic Resonance Imaging (fMRI) in Patients With Chronic Pancreatitis[NCT02458118]Phase 1/Phase 215 participants (Anticipated)Interventional2012-06-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for hydrogen and Pancreatitis

ArticleYear
Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.
    Life sciences, 2021, Jan-01, Volume: 264

    Topics: Animals; Antioxidants; Apoptosis; Autophagy; Cell Death; Endoplasmic Reticulum Stress; Humans; Hydro

2021
From nitric oxide to hyperbaric oxygen: invisible and subtle but nonnegligible gaseous signaling molecules in acute pancreatitis.
    Pancreas, 2014, Volume: 43, Issue:4

    Topics: Acute Disease; Animals; Carbon Monoxide; Gases; Humans; Hydrogen; Hydrogen Sulfide; Hyperbaric Oxyge

2014
Endoscopic measurement of pancreatic blood flow.
    Gastrointestinal endoscopy clinics of North America, 1994, Volume: 4, Issue:2

    Topics: Animals; Chronic Disease; Endoscopy, Digestive System; Humans; Hydrogen; Methods; Pancreas; Pancreat

1994

Trials

1 trial available for hydrogen and Pancreatitis

ArticleYear
Enzyme substitution in chronic pancreatitis: effects on clinical and functional parameters and on the hydrogen (H2) breath test.
    Scandinavian journal of gastroenterology. Supplement, 1986, Volume: 126

    Topics: Adult; Breath Tests; Carbohydrate Metabolism; Celiac Disease; Chronic Disease; Clinical Trials as To

1986

Other Studies

18 other studies available for hydrogen and Pancreatitis

ArticleYear
Association between increased breath hydrogen methane concentration and prevalence of glucose intolerance in acute pancreatitis.
    Journal of breath research, 2020, 02-14, Volume: 14, Issue:2

    Topics: Bacterial Infections; Blind Loop Syndrome; Breath Tests; Case-Control Studies; Female; Glucose; Gluc

2020
Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis while enhance the pancreatic Hsp60 protein expression.
    BMC gastroenterology, 2021, Apr-19, Volume: 21, Issue:1

    Topics: Administration, Inhalation; Animals; Ceruletide; Chaperonin 60; Disease Models, Animal; Female; Gase

2021
Association between acute pancreatitis and small intestinal bacterial overgrowth assessed by hydrogen breath test.
    World journal of gastroenterology, 2017, Dec-28, Volume: 23, Issue:48

    Topics: Adult; Aged; Bacteria; Bacterial Infections; Breath Tests; Female; Humans; Hydrogen; Incidence; Inte

2017
Increase in breath hydrogen concentration was correlated with the main pancreatic duct stenosis.
    Journal of breath research, 2018, 03-12, Volume: 12, Issue:3

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Breath Tests; Chronic Disease; Constriction, Patholog

2018
Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-κB pathway.
    Mediators of inflammation, 2015, Volume: 2015

    Topics: Acute Disease; Acute Kidney Injury; Amylases; Animals; Cytokines; Hydrogen; Kidney; Male; Neutrophil

2015
MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
    The FEBS journal, 2016, Volume: 283, Issue:4

    Topics: Acute Disease; Animals; Cell Line; Disease Models, Animal; HSC70 Heat-Shock Proteins; Hydrogen; Mice

2016
Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Amylases; Animals; Cell Line; Cell Survival; Ceruletide; Cytokines; Disease Models, Animal; Gene Exp

2016
Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats.
    Biochemical and biophysical research communications, 2010, Mar-05, Volume: 393, Issue:2

    Topics: Animals; Apoptosis; Arginine; Cell Proliferation; Disease Models, Animal; Hydrogen; Pancreas; Pancre

2010
Evidence of a generalized defect of acinar cell function in Shwachman-Diamond syndrome.
    Journal of pediatric gastroenterology and nutrition, 2010, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Bone Marrow Diseases; Breath Tests; Case-Control Studies; Child; Child, Preschool

2010
Hydrogen breath test with low-dose rice flour for assessment of exocrine pancreatic insufficiency.
    Pancreas, 2004, Volume: 29, Issue:4

    Topics: Adult; Breath Tests; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Female; Flour; Humans; Hydr

2004
Is the hydrogen clearance technique a useful tool for measurements of pancreatic blood flow during acute experimental pancreatitis?
    Pancreas, 1993, Volume: 8, Issue:1

    Topics: Acute Disease; Animals; Blood Flow Velocity; Dogs; Evaluation Studies as Topic; Hemodynamics; Hydrog

1993
Measurement of pancreatic blood flow with the intraductal electrode method of the hydrogen clearance technique in acute pancreatitis in rats.
    Pancreas, 1996, Volume: 13, Issue:3

    Topics: Acute Disease; Amylases; Animals; Blood Flow Velocity; Blood Pressure; Ceruletide; Electrodes; Hemat

1996
Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreatitis and control patients.
    Gastrointestinal endoscopy, 2000, Volume: 51, Issue:2

    Topics: Adult; Aged; Blood Flow Velocity; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease;

2000
Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreatitis and control patients.
    Gastrointestinal endoscopy, 2000, Volume: 51, Issue:2

    Topics: Adult; Aged; Blood Flow Velocity; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease;

2000
Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreatitis and control patients.
    Gastrointestinal endoscopy, 2000, Volume: 51, Issue:2

    Topics: Adult; Aged; Blood Flow Velocity; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease;

2000
Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreatitis and control patients.
    Gastrointestinal endoscopy, 2000, Volume: 51, Issue:2

    Topics: Adult; Aged; Blood Flow Velocity; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease;

2000
[Pancreatic local blood flow in experimental acute pancreatitis (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1979, Volume: 76, Issue:10

    Topics: Acute Disease; Animals; Hydrogen; Male; Pancreas; Pancreatitis; Plethysmography; Rats; Regional Bloo

1979
Clinical evaluation of a 25 g D-xylose hydrogen (H2) breath test.
    Zeitschrift fur Gastroenterologie, 1990, Volume: 28, Issue:10

    Topics: Adult; Aged; Breath Tests; Celiac Disease; Chronic Disease; Colonic Diseases, Functional; Digestive

1990
Identification of a characteristic 31P NMR signal in acute experimental pancreatitis with the aid of 1H-31P correlated 2D measurements of intact pancreas.
    Magnetic resonance in medicine, 1989, Volume: 10, Issue:1

    Topics: Animals; Hydrogen; Magnetic Resonance Spectroscopy; Male; Pancreas; Pancreatitis; Phosphorus; Rats;

1989
Comparison of bentiromide test and rice flour breath hydrogen test in the detection of exocrine pancreatic insufficiency.
    Pancreas, 1986, Volume: 1, Issue:2

    Topics: 4-Aminobenzoic Acid; Adult; Alcoholism; Aminobenzoates; Breath Tests; Exocrine Pancreatic Insufficie

1986
[Effect of delayed-action glucagon on stomach secretion in man].
    Medizinische Klinik, 1972, Apr-07, Volume: 67, Issue:14

    Topics: Chlorine; Delayed-Action Preparations; Gastric Juice; Gastric Mucosa; Glucagon; Humans; Hydrogen; Hy

1972