Page last updated: 2024-10-18

hydrogen and Malabsorption Syndromes

hydrogen has been researched along with Malabsorption Syndromes in 149 studies

Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.

Malabsorption Syndromes: General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.

Research Excerpts

ExcerptRelevanceReference
"In a randomized, double-blind, cross-over study, 27 consecutive patients with unexplained, self-reported food hypersensitivity were given 10 g lactulose and 10 g glucose (placebo)."9.14Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose. ( Berstad, A; Midtvedt, T; Morken, MH; Norin, E; Valeur, J, 2009)
"Using hydrogen breath testing (HBT) to diagnose small intestinal bacterial overgrowth (SIBO) remains controversial in patients with functional gastrointestinal (GI) disorders, and unknown in those with hypermobility Ehlers-Danlos syndrome (hEDS)."8.31Low prevalence of positive hydrogen breath tests in patients with functional gastrointestinal conditions and hypermobile Ehlers-Danlos syndrome. ( Brugaletta, C; Dervin, H; Emmanuel, A; Fragkos, K; Mensah, A; Raeburn, A; Sweis, R; Zarate-Lopez, N, 2023)
" This study was designed to test the hypothesis that chemotherapy produces lactose intolerance which could have an adverse effect on the nutritional status of patients receiving cytotoxic drugs."7.69Chemotherapy-induced lactose intolerance in adults. ( Fung, E; Parnes, HL; Schiffer, CA, 1994)
"In a randomized, double-blind, cross-over study, 27 consecutive patients with unexplained, self-reported food hypersensitivity were given 10 g lactulose and 10 g glucose (placebo)."5.14Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose. ( Berstad, A; Midtvedt, T; Morken, MH; Norin, E; Valeur, J, 2009)
"Evaluation of symptoms developed in response to the ingestion of 50 g lactose could represent a simple screening test to select patients for lactose intolerance testing."4.88Reliability of symptom analysis during carbohydrate hydrogen-breath tests. ( Fernández-Bañares, F, 2012)
"Using hydrogen breath testing (HBT) to diagnose small intestinal bacterial overgrowth (SIBO) remains controversial in patients with functional gastrointestinal (GI) disorders, and unknown in those with hypermobility Ehlers-Danlos syndrome (hEDS)."4.31Low prevalence of positive hydrogen breath tests in patients with functional gastrointestinal conditions and hypermobile Ehlers-Danlos syndrome. ( Brugaletta, C; Dervin, H; Emmanuel, A; Fragkos, K; Mensah, A; Raeburn, A; Sweis, R; Zarate-Lopez, N, 2023)
"The measurement of hydrogen-methane breath gases is widely used in gastroenterology to evaluate malabsorption syndromes and bacterial overgrowth."4.02Hydrogen-methane breath testing results influenced by oral hygiene. ( Erdrich, S; Harnett, JE; Hawrelak, JA; Myers, SP; Tan, ECK, 2021)
"The purpose of the present study was to ascertain whether pediatric patients with chronic abdominal pain had concurrent fructose intolerance as determined by a standardized dose breath hydrogen test (BHT), and whether symptoms would improve with a low-fructose diet."3.80Fructose intolerance/malabsorption and recurrent abdominal pain in children. ( Abdullah, B; Amoroso, PJ; Escobar, MA; Lustig, D; Pflugeisen, BM; Saeed, R; Shamdeen, S; Sherif, D; Tuider, J, 2014)
" Overall, 79 (39 %) patients with gastroparesis had evidence of SIBO by LBT: 30 (15 %) had positive H2@90min, 53 (26 %) positive DPHBT, and 6 (3 %) positive breath methane test."3.80Small intestinal bacterial overgrowth in gastroparesis. ( George, NS; Parkman, HP; Sankineni, A, 2014)
"Fructose absorption was measured using 3-hour breath hydrogen tests and symptom scores were used to rate subjective responses for gas, borborygmus, abdominal pain, and loose stools."3.73Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults. ( Beyer, PL; Caviar, EM; McCallum, RW, 2005)
"After sorbitol ingestion, celiac disease patients showed a significantly higher breath H(2) excretion than did healthy volunteers."3.72Mixing of the intestinal content and variations of fermentation capacity do not affect the results of hydrogen breath test. ( Corazza, GR; Di Stefano, M; Malservisi, S; Miceli, E; Missanelli, A; Strocchi, A, 2003)
"To investigate the prevalence of carbohydrate malabsorption and bacterial overgrowth in children with cystic fibrosis (CF) and abnormal stool pattern referred for breath hydrogen testing."3.70Bowel dysfunction in cystic fibrosis: importance of breath testing. ( Davidson, GP; Lewindon, PJ; Martin, AJ; Moore, DJ; Robb, TA, 1998)
" This study was designed to test the hypothesis that chemotherapy produces lactose intolerance which could have an adverse effect on the nutritional status of patients receiving cytotoxic drugs."3.69Chemotherapy-induced lactose intolerance in adults. ( Fung, E; Parnes, HL; Schiffer, CA, 1994)
" We found a strong association between lactose intolerance and persistent diarrheal disease in this population (p less than 0."3.68Gastrointestinal dysfunction and disaccharide intolerance in children infected with human immunodeficiency virus. ( Greenson, J; Hart, W; Oung, I; Perman, JA; Shiff, C; Yolken, RH, 1991)
"Erythritol is a nonglycemic sugar alcohol, and it has been suggested that erythritol is absorbed paracellularly."2.76Combination of erythritol and fructose increases gastrointestinal symptoms in healthy adults. ( Hertzler, SR; Kim, Y; Park, SC; Wolf, BW, 2011)
" We performed a dose-response study of fructose absorption in healthy subjects to develop a breath test to distinguish normal from abnormal fructose absorption capacity."2.73Ability of the normal human small intestine to absorb fructose: evaluation by breath testing. ( Anderson, L; Attaluri, A; Rao, SS; Stumbo, P, 2007)
"To determine whether infantile colic (IC) is associated with malabsorption of carbohydrates present in fruit juices."2.70Association between infantile colic and carbohydrate malabsorption from fruit juices in infancy. ( Cedillo, M; Duro, D; Lifshitz, F; Rising, R, 2002)
" In both cases no dose-response relation was observed."2.69Variations in colonic H2 and CO2 production as a cause of inadequate diagnosis of carbohydrate maldigestion in breath tests. ( de Bruijn, S; Koetse, HA; Pal, J; Pasterkamp, S; Stellaard, F; Vonk, RJ, 2000)
"Lactose malabsorption was diagnosed in 157 patients (68."2.68Lactose malabsorption and irritable bowel syndrome. Effect of a long-term lactose-free diet. ( Bilotta, T; Frandina, C; Frieri, G; Ricciardi, MR; Vernia, P, 1995)
"While lactose malabsorption is a well-investigated condition, few epidemiologic data are available for fructose and sorbitol malabsorption."1.42Carbohydrate Malabsorption and Putative Carbohydrate-Specific Small Intestinal Bacterial Overgrowth: Prevalence and Diagnostic Overlap Observed in an Austrian Outpatient Center. ( Enko, D; Halwachs-Baumann, G; Kimbacher, C; Kriegshäuser, G; Mangge, H; Stolba, R, 2015)
"In consecutive Caucasian patients with Crohn's disease (n = 87), ulcerative colitis (59), functional gastrointestinal disorders (FGID) (162), and healthy controls (76), area under the curve was calculated for lactulose (15 g)."1.39Semiquantitative assessment of breath hydrogen testing. ( Barrett, JS; Gibson, PR; Irving, PM; Kalubovila, U, 2013)
"omeprazole does not cause increased bacterial shall bowel overgrowth in elderly subjects."1.30The effect of long-term omeprazole on the glucose-hydrogen breath test in elderly patients. ( Hutchinson, S; Logan, R, 1997)
"The hydrogen breath test has been used to investigate the incidence of small-bowel bacterial overgrowth in 45 chronic alcoholics and in 60 controls with no history of alcohol abuse."1.29Breath hydrogen excretion in patients with alcoholic liver disease--evidence of small intestinal bacterial overgrowth. ( Bode, C; Bode, JC; Kolepke, R; Schäfer, K, 1993)
" Administration of lactulose at an increased dosage resulted in further significant (P less than 0."1.28Evaluation of carbohydrate malassimilation and intestinal transit time in cats by measurement of breath hydrogen excretion. ( Cripps, PJ; Gruffydd-Jones, TJ; Harbour, DA; Muir, P; Papassouliotis, K, 1991)
"Hydrogen production was higher in patients with sucrase-isomaltase deficiency (mean, 96 ppm; range, 20 ppm to 432ppm) than in those with secondary sucrose malabsorption (mean, 21 ppm; range, 12ppm to 51ppm)."1.27Detection of primary and secondary sucrose malabsorption in children by means of the breath hydrogen technique. ( Davidson, GP; Robb, TA, 1983)
"Lactose malabsorption was determined by breath H2 analyses after subjects drank four different test doses on 4 different days."1.26Effectiveness of milk products in dietary management of lactose malabsorption. ( Herd, LD; Manion, CV; Payne, DL; Tsegaye, A; Welsh, JD, 1981)

Research

Studies (149)

TimeframeStudies, this research(%)All Research%
pre-199062 (41.61)18.7374
1990's37 (24.83)18.2507
2000's15 (10.07)29.6817
2010's27 (18.12)24.3611
2020's8 (5.37)2.80

Authors

AuthorsStudies
Alegre, E1
Sandúa, A1
Calleja, S1
Deza, S1
González, Á1
Dervin, H1
Zarate-Lopez, N1
Sweis, R1
Mensah, A1
Fragkos, K1
Brugaletta, C1
Raeburn, A1
Emmanuel, A1
Helwig, U2
Koch, AK2
Reichel, C1
Jessen, P1
Büning, J1
Schreiber, S1
Langhorst, J2
Erdrich, S1
Tan, ECK1
Hawrelak, JA1
Myers, SP1
Harnett, JE1
Hammer, K3
Hasanagic, H1
Memaran, N2
Huber, WD2
Hammer, J4
Usai-Satta, P1
Oppia, F1
Lai, M1
Cabras, F1
Hammer, HF2
Fox, MR1
Keller, J1
Salvatore, S1
Basilisco, G1
Lopetuso, L1
Benninga, M1
Borrelli, O1
Dumitrascu, D1
Hauser, B1
Herszenyi, L1
Nakov, R1
Pohl, D1
Thapar, N1
Sonyi, M1
Kwiecień, J1
Hajzler, W1
Kosek, K1
Balcerowicz, S1
Grzanka, D1
Gościniak, W1
Górowska-Kowolik, K1
Hammer, V1
Koppka, N1
Holtmann, S1
Barrett, JS2
Kalubovila, U1
Irving, PM1
Gibson, PR2
Berg, LK1
Fagerli, E1
Martinussen, M1
Myhre, AO1
Florholmen, J1
Goll, R1
Däbritz, J1
Mühlbauer, M1
Domagk, D1
Voos, N1
Henneböhl, G1
Siemer, ML1
Foell, D1
Escobar, MA1
Lustig, D1
Pflugeisen, BM1
Amoroso, PJ1
Sherif, D1
Saeed, R1
Shamdeen, S1
Tuider, J1
Abdullah, B1
Sharma, A1
Srivastava, D1
Verma, A1
Misra, A1
Ghoshal, UC1
Huamán, JW1
Felip, A1
Guedea, E1
Jansana, M1
Videla, S1
Saperas, E1
Hanf, S1
Bögözi, T1
Keiner, R1
Frosch, T1
Popp, J1
Enko, D2
Kriegshäuser, G2
Kimbacher, C1
Stolba, R1
Mangge, H2
Halwachs-Baumann, G2
Andalib, I1
Shah, H1
Bal, BS1
Shope, TR1
Finelli, FC1
Koch, TR1
Stathopoulos, L1
King, SK1
Southwell, BR1
Hutson, JM1
Tuck, CJ2
Ross, LA1
Muir, JG1
Meinitzer, A1
Reininghaus, EZ1
Bengesser, SA1
Schnedl, WJ1
Yao, CK1
Valeur, J1
Morken, MH1
Norin, E1
Midtvedt, T1
Berstad, A1
Casellas, F3
Torrejón, A1
Vilaseca, J1
Aparici, A1
Casaus, M1
Rodríguez, P1
Guarner, F1
Odstrcil, EA1
Martinez, JG1
Santa Ana, CA1
Xue, B1
Schneider, RE1
Steffer, KJ1
Porter, JL1
Asplin, J1
Kuhn, JA1
Fordtran, JS1
Jones, HF3
Butler, RN3
Brooks, DA3
Davidson, GP5
Burt, E1
Dowling, K1
Davidson, G1
Frieling, T1
Kuhlbusch-Zicklam, R1
Kalde, S1
Heise, J1
Hülsdonk, A1
Kreysel, C1
Kim, Y1
Park, SC1
Wolf, BW1
Hertzler, SR1
Casterton, PL1
Verbeke, KA1
Brouns, F1
Dammann, KW1
Knudsen, CD1
Di Palma, JA1
Fernández-Bañares, F2
George, NS1
Sankineni, A1
Parkman, HP1
Mitsui, T1
Kagami, H1
Kinomoto, H1
Ito, A1
Kondo, T2
Shimaoka, K1
Di Stefano, M1
Miceli, E1
Malservisi, S2
Missanelli, A1
Strocchi, A4
Corazza, GR2
Mishkin, DS1
Mishkin, S1
Blank, D1
Yalovsky, M1
Vernia, P2
Marinaro, V1
Argnani, F1
Di Camillo, M1
Caprilli, R1
Beyer, PL1
Caviar, EM1
McCallum, RW1
Simrén, M1
Stotzer, PO1
Rao, SS1
Attaluri, A1
Anderson, L1
Stumbo, P1
Ojetti, V1
Gabrielli, M1
Migneco, A1
Lauritano, C1
Zocco, MA1
Scarpellini, E1
Nista, EC1
Gasbarrini, G4
Gasbarrini, A1
Almeida, JA1
Kim, R1
Stoita, A1
McIver, CJ2
Kurtovic, J1
Riordan, SM2
Flourie, B2
Florent, C2
Rambaud, JC2
King, CE1
Toskes, PP1
Piqué Badía, JM1
Griffin, GC1
Kwong, LK1
Morrill, JS1
Vreman, HJ1
Stevenson, DK1
Newcomer, AD1
van der Klei-van Moorsel, JM1
Douwes, AC3
van Oeveren, JP1
Kerlin, P1
Wong, L1
Harris, B1
Capra, S1
Welsh, JD2
Griffiths, WJ1
Shermeta, DW1
Ruaz, E1
Fink, BB1
MacLean, WC1
Payne, DL1
Manion, CV1
Tsegaye, A2
Herd, LD1
Lifschitz, CH1
Irving, CS1
Gopalakrishna, GS1
Evans, K1
Nichols, BL1
Beró, T1
Past, T1
Tapsonyi, Z1
Mózsik, G1
Jávor, T1
Caspary, WF4
Robb, TA3
Kotler, DP1
Holt, PR2
Rosensweig, NS1
Lembcke, B2
Fölsch, UR2
Ebert, R1
Creutzfeldt, W2
Feibusch, JM1
Lo, CW1
Carter, EA2
Walker, WA3
Anderson, IH1
Levine, AS1
Levitt, MD6
Solomons, NW2
Bloch, KJ1
Cohen, S1
Isselbacher, KJ2
Ruppin, H1
Domschke, W1
van Caillie, M1
Fernandes, J3
Bijleveld, CM2
Desjeux, JF1
Nakajima, T1
Saiki, Y1
Kaneko, M1
Takahashi, T1
Ishikawa, M1
Oosterkamp, RF1
Los, T1
Jongbloed, AA1
Bartlett, K1
Dobson, JV1
Eastham, E1
Ricciardi, MR1
Frandina, C1
Bilotta, T1
Frieri, G1
Carlson, S1
Craig, RM1
Hoekstra, JH3
Rumessen, JJ3
Nordgaard-Andersen, I1
Gudmand-Høyer, E3
Soergel, KH1
Malagelada, JR2
Benati, G1
Gassull, MA1
Parnes, HL1
Fung, E1
Schiffer, CA1
Tajiri, H1
Hamamoto, T1
Harada, T1
Okada, S1
O'Brien, S1
Mulcahy, H1
Fenlon, H1
O'Broin, A1
Casey, M1
Burke, A1
FitzGerald, MX1
Hegarty, JE1
Corazza, G2
Sorge, M1
Bentai, G1
Ellis, CJ1
Chicharro, L1
van Kempen, AA1
Kneepkens, CM3
Bode, C1
Kolepke, R1
Schäfer, K1
Bode, JC1
Ouwendijk, J1
Moolenaar, CE1
Peters, WJ1
Hollenberg, CP1
Ginsel, LA1
Fransen, JA1
Naim, HY1
Bolin, TD3
Genge, JR1
Duncombe, VM3
Hutchinson, S1
Logan, R1
Lewindon, PJ1
Moore, DJ1
Martin, AJ1
Sobajima, H1
Mori, M1
Niwa, T1
Muramatsu, M1
Sugimoto, Y1
Kato, K1
Naruse, S1
Hayakawa, T1
Ledochowski, M3
Sperner-Unterweger, B2
Widner, B2
Fuchs, D3
Propst-Braunsteiner, T1
Vogel, W1
Koetse, HA1
Vonk, RJ2
Pasterkamp, S1
Pal, J1
de Bruijn, S1
Stellaard, F1
Thomas, MC1
Ladas, SD1
Grammenos, I1
Tassios, PS1
Raptis, SA1
Murr, C1
Lass-Flörl, C1
Duro, D1
Rising, R1
Cedillo, M1
Lifshitz, F1
Cook, GC1
Barr, RG2
Perman, JA4
Schoeller, DA1
Watkins, JB2
Prins, RA1
Viteri, F1
Rosenberg, IH1
Payne-Bose, D1
Morrison, RD1
Waller, GR1
Bond, JH4
Metz, G1
Blendis, LM1
Jenkins, DJ2
Zuin, G1
Fontana, M1
Monti, S1
Marchisio, P1
Beretta, P1
Principi, N1
Vantrappen, G1
Ghoos, Y1
Andriulli, A1
Donald, IP1
Kitchingmam, G1
Donald, F1
Kupfer, RM1
Muir, P1
Papassouliotis, K1
Gruffydd-Jones, TJ1
Cripps, PJ1
Harbour, DA1
Akanji, AO1
Hockaday, TD1
Pereira, SP1
Linklater, JM1
Yolken, RH1
Hart, W1
Oung, I1
Shiff, C1
Greenson, J1
Diederich, M1
Hamberg, O1
Nelis, GF1
Vermeeren, MA1
Jansen, W1
Davies, AG1
Fitzgerald, A1
Holland, RE2
Herdt, TH2
Refsal, KR2
Wolever, TM1
Cohen, Z1
Thompson, LU1
Thorne, MJ1
Jenkins, MJ1
Prokipchuk, EJ1
Ford, RP1
Barnes, GL1
Hill, DJ1
Winter, HS1
Leblond, A1
Rautureau, M1
Bisalli, A1
Levine, JJ1
Seidman, E1
Bodánszky, H2
Horváth, K2
Bata, A2
Horn, G2
Simon, K2
Washabau, RJ2
Strombeck, DR2
Buffington, CA2
Harrold, D2
Kien, CL1
Liechty, EA1
Myerberg, DZ1
Mullett, MD1
Mikó, P1
Farsang, C1
Kiss, R1
Arányi, I1
Fehér, J1
Coyne, MJ1
Rodriguez, H1
Batt, RM1
Hayashi, JT1
Wolfe, BM1
Calvert, CC1
Hyams, JS1
Leichtner, AM1
Sarles, J1
Collard, Y1
Arnaud-Battandier, F1
Bresson, JL1
Schmitz, J1
Ricour, C1
Rey, J1
Berggren, T1
Hastings, J1
Olsen, WA1
Rasmussen, HK1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Autonomic Neuropathy, Gastrointestinal Motility, and Inflammation in HIV[NCT02850276]Early Phase 176 participants (Actual)Interventional2015-11-30Completed
Evaluation of the Therapeutic Effect of Rifaximin on Covert Hepatic Encephalopathy With Underlying Small Intestinal Bacterial Overgrowth and Gastrointestinal Dysmotility in Liver Cirrhosis Patients[NCT04244877]Phase 30 participants (Actual)Interventional2021-09-15Withdrawn (stopped due to Study was unable to recruit participants..)
Colonic Microbial and Clinical Adaptation to Large Doses of Fructose[NCT00775567]45 participants (Actual)Interventional2008-01-31Completed
The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION Trial): Protocol of a Multicentre Randomized Controlled Clinical Trial[NCT05100719]200 participants (Anticipated)Interventional2022-09-30Not yet recruiting
Evaluation of the Impact of LacTEST on Diagnostic Thinking and on Patient Management, and of the Reproducibility (Test-Retest), for the Diagnosis of Hypolactasia in Adults and Elderly Patients Presenting With Clinical Symptoms of Lactose Intolerance[NCT02636413]Phase 41 participants (Actual)Interventional2015-10-31Completed
Effects of FODMAPs (Fermentable Oligo-, Di-, and Mono-saccharides, And Polyols) on Small Bowel Water Content: an MRI Study[NCT01459406]17 participants (Actual)Interventional2011-10-31Completed
Fructose and Fructans and Irritable Bowel Syndrome: MRI Study of Underlying Mechanisms[NCT01776853]69 participants (Actual)Interventional2013-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Reduction in Small Intestinal Bacterial Overgrowth (SIBO)

"Number of participants with reduction in Small intestinal bacterial overgrowth (SIBO) assessed with breath testing after 8 weeks of treatment.~The hydrogen breath test for the detection of small intestinal bacterial overgrowth (SIBO), obtained by having participants exhale into a plastic bag. the hydrogen content of the samples is measured using a commercially available analyzer." (NCT02850276)
Timeframe: week 8

InterventionParticipants (Count of Participants)
Pyridostigmine13

Change in Breath Test

Breath Test at week 8 as compared to baseline. Breath test results is the rise in the combined hydrogen and methane during the breath test. (NCT02850276)
Timeframe: baseline and week 8

Interventionppm (Median)
Baselineweek 8
Pyridostigmine2814

Change in IL-6 Plasma Level

Change in IL-6 plasma level at week 8 as compared to baseline. Plasma interleukin-6 (IL-6), an important inflammatory mediator which predicts mortality in HIV as well as multiple medical co-morbidities, presumably via inflammatory mechanisms. (NCT02850276)
Timeframe: Baseline and week 8

Interventionmean florescence intensity (Median)
BaselineWeek 8
Pyridostigmine30.526.5

Change in sCD14 Level

Change in sCD14 level at week 8 as compared to baseline. sCD14 is a marker of macrophage activation commonly used as an indirect measure of translocation (NCT02850276)
Timeframe: Baseline and week 8

Interventionmean florescence intensity (Median)
BaselineWeek 8
Pyridostigmine25732095

Change in TNFα Level

TNFα is a pro-inflammatory cytokine which is induced by components of translocating bacteria. Change in TNFα level at week 8 compared to baseline (NCT02850276)
Timeframe: Baseline and week 8

Interventionmean florescence intensity (Median)
Baselineweek 8
Pyridostigmine134.0117.5

Mean Percent Retention of Gastric Contents on Gastric Emptying Study

Percent retention of gastric contents on gastric emptying study. GI dysmotility calculated from gastric emptying scintigraphy - measurement of the percent retention of gastric contents at 4 hours. (NCT02850276)
Timeframe: Baseline and week 8

Interventionpercent retention of gastric contents (Mean)
Baselineweek 8
Pyridostigmine32

Medical Outcomes Study Questionnaire

Medical Outcomes Study (MOS-HIV) quality of life questionnaire. It is a 35 item questionnaire covering 11 dimensions of health including physical functioning, role functioning, pain, social functioning, emotional well-being, energy/fatigue, cognitive functioning, general health, health distress, overall QOL, and health transition. The total scale ranges from 0-100 with a higher score representing better functioning and well-being. (NCT02850276)
Timeframe: Baseline and week 8

Interventionscore on a scale (Mean)
BaselineWeek 8
Pyridostigmine66.165

The Composite Autonomic Symptom Score (COMPASS)

The gastrointestinal domain domain score of the COMPASS contains 12 items which reflect gastrointestinal symptoms of autonomic function. It is scored on a total scale of 0-28, with higher numbers reflecting worse symptoms. (NCT02850276)
Timeframe: Baseline and week 8

Interventionscore on a scale (Mean)
BaselineWeek 8
Pyridostigmine88.6

Reviews

14 reviews available for hydrogen and Malabsorption Syndromes

ArticleYear
Hydrogen Breath Tests: Are They Really Useful in the Nutritional Management of Digestive Disease?
    Nutrients, 2021, Mar-17, Volume: 13, Issue:3

    Topics: Breath Tests; Carbohydrate Metabolism; Humans; Hydrogen; Malabsorption Syndromes

2021
European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Neurogastroenterology and Mot
    United European gastroenterology journal, 2022, Volume: 10, Issue:1

    Topics: Adult; Breath Tests; Carbohydrate Metabolism; Child; Consensus; Dietary Carbohydrates; Dysbiosis; En

2022
The clinical value of breath hydrogen testing.
    Journal of gastroenterology and hepatology, 2017, Volume: 32 Suppl 1

    Topics: Biomarkers; Breath Tests; Dietary Carbohydrates; Fermentation; Gastrointestinal Microbiome; Humans;

2017
Intestinal fructose transport and malabsorption in humans.
    American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 300, Issue:2

    Topics: Absorption; Aging; Animals; Biological Transport; Breath Tests; Exhalation; Fructose; Glucose; Gluco

2011
Reliability of symptom analysis during carbohydrate hydrogen-breath tests.
    Current opinion in clinical nutrition and metabolic care, 2012, Volume: 15, Issue:5

    Topics: Breath Tests; Diet; Dietary Sucrose; Fructose; Humans; Hydrogen; Intestinal Diseases; Lactose; Lacto

2012
Diarrhea caused by carbohydrate malabsorption.
    Gastroenterology clinics of North America, 2012, Volume: 41, Issue:3

    Topics: Anti-Bacterial Agents; Bacteria; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Diarrhea; Die

2012
Use and abuse of hydrogen breath tests.
    Gut, 2006, Volume: 55, Issue:3

    Topics: Bacteria; Bacterial Infections; Breath Tests; Dietary Carbohydrates; Gastrointestinal Diseases; Huma

2006
[Hydrogen breath tests].
    Gastroenterologie clinique et biologique, 1984, Volume: 8, Issue:2

    Topics: Breath Tests; Glucose; Humans; Hydrogen; Lactose; Lactulose; Malabsorption Syndromes; Polysaccharide

1984
The use of breath tests in the study of malabsorption.
    Clinics in gastroenterology, 1983, Volume: 12, Issue:2

    Topics: Bile Acids and Salts; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Glucose; Humans; Hydrogen;

1983
[Use of breath tests in gastroenterology].
    Medicina clinica, 1983, Apr-23, Volume: 80, Issue:14

    Topics: Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Gastrointestinal Motility; Humans; Hydrogen; Int

1983
Breath tests in pediatric gastrointestinal disorders: new diagnostic opportunities.
    Pediatrics, 1978, Volume: 62, Issue:3

    Topics: Bacterial Infections; Breath Tests; Carbohydrate Metabolism; Carbon Isotopes; Carbon Radioisotopes;

1978
Co2- and H2 breath tests in the diagnosis of intestinal malabsorption.
    The Italian journal of gastroenterology, 1992, Volume: 24, Issue:4

    Topics: Breath Tests; Carbon Dioxide; Diagnosis, Differential; Humans; Hydrogen; Malabsorption Syndromes

1992
Clinical application of breath hydrogen measurements.
    Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:1

    Topics: Breath Tests; Dietary Carbohydrates; Humans; Hydrogen; Malabsorption Syndromes

1991
Breath tests as a diagnostic technique for malabsorption.
    Pediatric annals, 1987, Volume: 16, Issue:3

    Topics: Breath Tests; Gases; Humans; Hydrogen; Infant; Infant, Newborn; Intestines; Lactose; Malabsorption S

1987

Trials

17 trials available for hydrogen and Malabsorption Syndromes

ArticleYear
Relationship Between Abdominal Symptoms and Fructose Ingestion in Children with Chronic Abdominal Pain.
    Digestive diseases and sciences, 2018, Volume: 63, Issue:5

    Topics: Abdominal Pain; Adolescent; Biomarkers; Breath Tests; Child; Chronic Pain; Dietary Sugars; Female; F

2018
Effect of fructose-reduced diet in patients with irritable bowel syndrome, and its correlation to a standard fructose breath test.
    Scandinavian journal of gastroenterology, 2013, Volume: 48, Issue:8

    Topics: Adolescent; Adult; Aged; Biomarkers; Breath Tests; Dietary Carbohydrates; Female; Fructose; Humans;

2013
[The diet low in fermentable carbohydrates short chain and polyols improves symptoms in patients with functional gastrointestinal disorders in Spain].
    Gastroenterologia y hepatologia, 2015, Volume: 38, Issue:3

    Topics: Adult; Breath Tests; Comorbidity; Dietary Carbohydrates; Female; Fermentation; Gastrointestinal Dise

2015
Adding glucose to food and solutions to enhance fructose absorption is not effective in preventing fructose-induced functional gastrointestinal symptoms: randomised controlled trials in patients with fructose malabsorption.
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2017, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Aged; Australia; Breath Tests; Cross-Over Studies; Diet; Double-Blind Method; End

2017
Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose.
    Scandinavian journal of gastroenterology, 2009, Volume: 44, Issue:12

    Topics: Adolescent; Adult; Breath Tests; Carbohydrates; Cross-Over Studies; Dinoprostone; Double-Blind Metho

2009
Combination of erythritol and fructose increases gastrointestinal symptoms in healthy adults.
    Nutrition research (New York, N.Y.), 2011, Volume: 31, Issue:11

    Topics: Adult; Beverages; Breath Tests; Cross-Over Studies; Dietary Carbohydrates; Double-Blind Method; Drug

2011
Evaluation of sucromalt digestion in healthy children using breath hydrogen as a biomarker of carbohydrate malabsorption.
    Food & function, 2012, Volume: 3, Issue:4

    Topics: Biomarkers; Breath Tests; Child; Dietary Carbohydrates; Digestion; Disaccharides; Female; Fructose;

2012
Ability of the normal human small intestine to absorb fructose: evaluation by breath testing.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007, Volume: 5, Issue:8

    Topics: Adult; Aged; Air; Breath Tests; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follo

2007
Influence of metronidazole on the breath hydrogen response and symptoms in acarbose-induced malabsorption of sucrose.
    Digestion, 1982, Volume: 25, Issue:3

    Topics: Acarbose; Adolescent; Adult; Air; Double-Blind Method; Humans; Hydrogen; Intestinal Absorption; Mala

1982
Lactose malabsorption and irritable bowel syndrome. Effect of a long-term lactose-free diet.
    The Italian journal of gastroenterology, 1995, Volume: 27, Issue:3

    Topics: Adult; Breath Tests; Chi-Square Distribution; Colonic Diseases, Functional; Diet; Female; Humans; Hy

1995
Carbohydrate malabsorption: quantification by methane and hydrogen breath tests.
    Scandinavian journal of gastroenterology, 1994, Volume: 29, Issue:9

    Topics: Adult; Breath Tests; Female; Humans; Hydrogen; Intestinal Absorption; Lactulose; Malabsorption Syndr

1994
Fructans of chicory: intestinal transport and fermentation of different chain lengths and relation to fructose and sorbitol malabsorption.
    The American journal of clinical nutrition, 1998, Volume: 68, Issue:2

    Topics: Acetates; Adolescent; Adult; Biological Transport; Blood Glucose; Cross-Over Studies; Female; Fermen

1998
Variations in colonic H2 and CO2 production as a cause of inadequate diagnosis of carbohydrate maldigestion in breath tests.
    Scandinavian journal of gastroenterology, 2000, Volume: 35, Issue:6

    Topics: Adult; Breath Tests; Carbohydrate Metabolism; Carbon Dioxide; Colon; Female; Humans; Hydrogen; Intes

2000
Association between infantile colic and carbohydrate malabsorption from fruit juices in infancy.
    Pediatrics, 2002, Volume: 109, Issue:5

    Topics: Analysis of Variance; Beverages; Breath Tests; Carbohydrate Metabolism; Colic; Crying; Double-Blind

2002
Effect of short-term intermittent antibiotic treatment on growth of Burmese (Myanmar) village children.
    Lancet (London, England), 1990, Nov-03, Volume: 336, Issue:8723

    Topics: Age Factors; Amoxicillin; Bacterial Infections; Body Height; Body Weight; Breath Tests; Child, Presc

1990
Postprandial glycemic control, hormonal effects and carbohydrate malabsorption during long-term administration of the alpha-glucosidase inhibitor miglitol.
    Digestion, 1990, Volume: 47, Issue:1

    Topics: 1-Deoxynojirimycin; Adult; Blood Glucose; Breath Tests; Dietary Carbohydrates; Double-Blind Method;

1990
Dietary carbohydrate assimilation in the premature infant: evidence for a nutritionally significant bacterial ecosystem in the colon.
    The American journal of clinical nutrition, 1987, Volume: 46, Issue:3

    Topics: Bacteria; Breath Tests; Colon; Dietary Carbohydrates; Humans; Hydrogen; Infant Nutritional Physiolog

1987

Other Studies

118 other studies available for hydrogen and Malabsorption Syndromes

ArticleYear
Modification of baseline status to improve breath tests performance.
    Scientific reports, 2022, 06-13, Volume: 12, Issue:1

    Topics: Breath Tests; Carbohydrates; Humans; Hydrogen; Malabsorption Syndromes; Retrospective Studies

2022
Low prevalence of positive hydrogen breath tests in patients with functional gastrointestinal conditions and hypermobile Ehlers-Danlos syndrome.
    Neurogastroenterology and motility, 2023, Volume: 35, Issue:9

    Topics: Adult; Breath Tests; Diarrhea; Ehlers-Danlos Syndrome; Female; Gastrointestinal Diseases; Humans; Hy

2023
A Prospective Multicenter Study on the Prevalence of Fructose Malabsorption in Patients with Chronic Inflammatory Bowel Disease.
    Digestion, 2021, Volume: 102, Issue:3

    Topics: Breath Tests; Fructose; Humans; Hydrogen; Inflammatory Bowel Diseases; Lactose Intolerance; Malabsor

2021
Hydrogen-methane breath testing results influenced by oral hygiene.
    Scientific reports, 2021, 01-08, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Breath Tests; Dysbiosis; Exhalation; Female; Gases; Gastrointestinal Diseas

2021
Relevance of Methane and Carbon Dioxide Evaluation in Breath Tests for Carbohydrate Malabsorption in a Paediatric Cohort.
    Journal of pediatric gastroenterology and nutrition, 2021, 03-01, Volume: 72, Issue:3

    Topics: Adolescent; Breath Tests; Carbon Dioxide; Child; Fructose; Humans; Hydrogen; Lactose Intolerance; Ma

2021
No Correlation between Positive Fructose Hydrogen Breath Test and Clinical Symptoms in Children with Functional Gastrointestinal Disorders: A Retrospective Single-Centre Study.
    Nutrients, 2021, Aug-23, Volume: 13, Issue:8

    Topics: Adolescent; Age Factors; Breath Tests; Child; Child, Preschool; Dietary Sugars; Female; Fructose; Ga

2021
The Predictive Value of the Hydrogen Breath Test in the Diagnosis of Fructose Malabsorption.
    Digestion, 2019, Volume: 99, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Child; Female; Fructose; Humans; Hydrogen;

2019
Semiquantitative assessment of breath hydrogen testing.
    Journal of gastroenterology and hepatology, 2013, Volume: 28, Issue:9

    Topics: Adult; Breath Tests; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Female; Fructose; Gas

2013
Significance of hydrogen breath tests in children with suspected carbohydrate malabsorption.
    BMC pediatrics, 2014, Feb-27, Volume: 14

    Topics: Adolescent; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Female; F

2014
Fructose intolerance/malabsorption and recurrent abdominal pain in children.
    Journal of pediatric gastroenterology and nutrition, 2014, Volume: 58, Issue:4

    Topics: Abdominal Pain; Adolescent; Breath Tests; Child; Child, Preschool; Dietary Carbohydrates; Female; Fr

2014
Fructose malabsorption is not uncommon among patients with irritable bowel syndrome in India: a case-control study.
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2014, Volume: 33, Issue:5

    Topics: Adolescent; Adult; Aged; Biomarkers; Breath Tests; Case-Control Studies; Female; Fructose; Humans; H

2014
Fast and highly sensitive fiber-enhanced Raman spectroscopic monitoring of molecular H2 and CH4 for point-of-care diagnosis of malabsorption disorders in exhaled human breath.
    Analytical chemistry, 2015, Jan-20, Volume: 87, Issue:2

    Topics: Bacterial Infections; Breath Tests; Exhalation; Fiber Optic Technology; Humans; Hydrogen; Intestines

2015
Carbohydrate Malabsorption and Putative Carbohydrate-Specific Small Intestinal Bacterial Overgrowth: Prevalence and Diagnostic Overlap Observed in an Austrian Outpatient Center.
    Digestion, 2015, Volume: 92, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Austria; Blind Loop Syndrome

2015
Breath Hydrogen as a Biomarker for Glucose Malabsorption after Roux-en-Y Gastric Bypass Surgery.
    Disease markers, 2015, Volume: 2015

    Topics: Adult; Biomarkers; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Female; Gastric Bypass; Hum

2015
Nuclear transit study in children with chronic faecal soiling after Hirschsprung disease (HSCR) surgery has revealed a group with rapid proximal colonic treatment and possible adverse reactions to food.
    Pediatric surgery international, 2016, Volume: 32, Issue:8

    Topics: Adolescent; Breath Tests; Child; Child, Preschool; Fecal Incontinence; Food Hypersensitivity; Fructo

2016
Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption.
    Canadian journal of gastroenterology & hepatology, 2016, Volume: 2016

    Topics: Abdominal Pain; Adult; Amine Oxidase (Copper-Containing); Breath Tests; Carbohydrates; Diet; Female;

2016
Influence of colectomy on hydrogen excretion in breath.
    International journal of colorectal disease, 2010, Volume: 25, Issue:4

    Topics: Adult; Aged; Breath Tests; Carbohydrate Metabolism; Chromatography, Gas; Colectomy; Exhalation; Fema

2010
The contribution of malabsorption to the reduction in net energy absorption after long-limb Roux-en-Y gastric bypass.
    The American journal of clinical nutrition, 2010, Volume: 92, Issue:4

    Topics: Adult; Barium Sulfate; Body Mass Index; Body Size; Diabetes Mellitus; Dietary Proteins; Duodenum; Ea

2010
Is small-bowel bacterial overgrowth an underdiagnosed disorder in children with gastrointestinal symptoms?
    Journal of pediatric gastroenterology and nutrition, 2011, Volume: 52, Issue:5

    Topics: Abdominal Pain; Adolescent; Blind Loop Syndrome; Breath Tests; Child; Child, Preschool; Chronic Dise

2011
Effect of age on fructose malabsorption in children presenting with gastrointestinal symptoms.
    Journal of pediatric gastroenterology and nutrition, 2011, Volume: 52, Issue:5

    Topics: Adolescent; Adult; Age Factors; Aged; Breath Tests; Child; Dietary Carbohydrates; Female; Fructose;

2011
Fructose malabsorption: how much fructose can a healthy subject tolerate?
    Digestion, 2011, Volume: 84, Issue:4

    Topics: Abdominal Pain; Adolescent; Adult; Breath Tests; Diarrhea; Diet Records; Female; Flatulence; Fructos

2011
Carbohydrate challenge tests: do you need to measure methane?
    Southern medical journal, 2012, Volume: 105, Issue:5

    Topics: Breath Tests; Carbohydrate Metabolism; Female; Humans; Hydrogen; Lactose Intolerance; Malabsorption

2012
Small intestinal bacterial overgrowth in gastroparesis.
    Digestive diseases and sciences, 2014, Volume: 59, Issue:3

    Topics: Adult; Biomarkers; Breath Tests; Female; Gastroparesis; Humans; Hydrogen; Intestine, Small; Lactulos

2014
Small bowel bacterial overgrowth and rice malabsorption in healthy and physically disabled older adults.
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2003, Volume: 16, Issue:2

    Topics: Aged; Aging; Breath Tests; Disabled Persons; Enterobacteriaceae; Exercise; Fasting; Female; Gastroin

2003
Mixing of the intestinal content and variations of fermentation capacity do not affect the results of hydrogen breath test.
    The American journal of gastroenterology, 2003, Volume: 98, Issue:7

    Topics: Adult; Artifacts; Breath Tests; Carbohydrate Metabolism; Case-Control Studies; Celiac Disease; Colon

2003
Does the addition of methane determinations increase the yield of hydrogen breath tests for sugar malabsorption?
    The American journal of gastroenterology, 2004, Volume: 99, Issue:4

    Topics: Breath Tests; Carbohydrate Metabolism; Humans; Hydrogen; Malabsorption Syndromes; Methane; Reproduci

2004
Self-reported milk intolerance in irritable bowel syndrome: what should we believe?
    Clinical nutrition (Edinburgh, Scotland), 2004, Volume: 23, Issue:5

    Topics: Adult; Breath Tests; Female; Humans; Hydrogen; Irritable Bowel Syndrome; Lactose Intolerance; Malabs

2004
Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults.
    Journal of the American Dietetic Association, 2005, Volume: 105, Issue:10

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Diarrhea; Dietary Carbohydrates; Dose-Respons

2005
Regression of lactose malabsorption in coeliac patients after receiving a gluten-free diet.
    Scandinavian journal of gastroenterology, 2008, Volume: 43, Issue:2

    Topics: Adult; Atrophy; Biopsy; Breath Tests; Celiac Disease; Duodenum; Endoscopy, Digestive System; Female;

2008
Lactose malabsorption in the elderly: role of small intestinal bacterial overgrowth.
    Scandinavian journal of gastroenterology, 2008, Volume: 43, Issue:2

    Topics: Age Distribution; Aged; Aged, 80 and over; Breath Tests; Female; Humans; Hydrogen; Intestinal Mucosa

2008
Hydrogen gas excretion after sucrose gavage in the fasted rat.
    The American journal of clinical nutrition, 1984, Volume: 40, Issue:4

    Topics: Animals; Chromatography, Gas; Dietary Carbohydrates; Fasting; Female; Hydrogen; Lactulose; Malabsorp

1984
Screening tests for carbohydrate malabsorption.
    Journal of pediatric gastroenterology and nutrition, 1984, Volume: 3, Issue:1

    Topics: Adult; Breath Tests; Child; Dietary Carbohydrates; Humans; Hydrogen; Intestinal Mucosa; Malabsorptio

1984
New principle for estimation of hydrogen in expired air.
    European journal of pediatrics, 1984, Volume: 141, Issue:4

    Topics: Adult; Breath Tests; Carbohydrate Metabolism; Child; Chromatography, Gas; Humans; Hydrogen; Lactose

1984
Rice flour, breath hydrogen, and malabsorption.
    Gastroenterology, 1984, Volume: 87, Issue:3

    Topics: Adult; Breath Tests; Celiac Disease; Crohn Disease; Dietary Carbohydrates; Exocrine Pancreatic Insuf

1984
Breath hydrogen test after oral lactose in postgastrectomy patients.
    The American journal of clinical nutrition, 1980, Volume: 33, Issue:11

    Topics: Animals; beta-Galactosidase; Blood Glucose; Breath Tests; Diarrhea; Female; Gastrectomy; Humans; Hyd

1980
Respiratory hydrogen secretion: a simple test of bowel adaptation in infants with short gut syndrome.
    Journal of pediatric surgery, 1981, Volume: 16, Issue:3

    Topics: Adaptation, Physiological; Breath Tests; Enteral Nutrition; Humans; Hydrogen; Infant, Newborn; Infan

1981
Effectiveness of milk products in dietary management of lactose malabsorption.
    The American journal of clinical nutrition, 1981, Volume: 34, Issue:12

    Topics: Adult; Animals; beta-Galactosidase; Breath Tests; Cattle; Female; Galactosidases; Humans; Hydrogen;

1981
Carbohydrate malabsorption in infants with diarrhea studied with the breath hydrogen test.
    The Journal of pediatrics, 1983, Volume: 102, Issue:3

    Topics: Breath Tests; Carbohydrate Metabolism; Colon; Diarrhea, Infantile; Feces; Fermentation; Glucose; Hum

1983
[Clinical significance of H2 determination in breath. A new method for the detection of carbohydrate malabsorption (preliminary report)].
    Orvosi hetilap, 1983, Jan-09, Volume: 124, Issue:2

    Topics: Breath Tests; Carbohydrate Metabolism, Inborn Errors; Humans; Hydrogen; Intestinal Absorption; Malab

1983
[Importance of the colon as a utilizer of energy].
    Deutsche medizinische Wochenschrift (1946), 1983, May-06, Volume: 108, Issue:18

    Topics: Breath Tests; Carbohydrate Metabolism; Colon; Energy Metabolism; Fermentation; Humans; Hydrogen; Mal

1983
Detection of primary and secondary sucrose malabsorption in children by means of the breath hydrogen technique.
    The Medical journal of Australia, 1983, Jul-09, Volume: 2, Issue:1

    Topics: Breath Tests; Carbohydrate Metabolism, Inborn Errors; Child; Humans; Hydrogen; Malabsorption Syndrom

1983
Modification of the breath hydrogen test: increased sensitivity for the detection of carbohydrate malabsorption.
    The Journal of laboratory and clinical medicine, 1982, Volume: 100, Issue:5

    Topics: Breath Tests; Carbohydrate Metabolism; Humans; Hydrogen; Lactulose; Malabsorption Syndromes; Time Fa

1982
Impaired absorptive capacity for carbohydrate in the aging human.
    Digestive diseases and sciences, 1982, Volume: 27, Issue:12

    Topics: Aged; Aging; Breath Tests; Dietary Carbohydrates; Humans; Hydrogen; Intestinal Absorption; Malabsorp

1982
Breath tests: principles, problems, and promise.
    Advances in pediatrics, 1982, Volume: 29

    Topics: Bile Acids and Salts; Breath Tests; Child; Dietary Carbohydrates; Dietary Fats; Gases; Humans; Hydro

1982
Incomplete absorption of the carbohydrate in all-purpose wheat flour.
    The New England journal of medicine, 1981, Apr-09, Volume: 304, Issue:15

    Topics: Adolescent; Adult; Bread; Breath Tests; Dietary Carbohydrates; Flour; Glutens; Humans; Hydrogen; Int

1981
The hydrogen breath test and gastrointestinal disorders.
    Comprehensive therapy, 1981, Volume: 7, Issue:8

    Topics: Adult; Breath Tests; Child, Preschool; Gastrointestinal Diseases; Gastrointestinal Motility; Humans;

1981
Use of hydrogen gas (H2) analysis to assess intestinal absorption. Studies in normal rats and in rats infected with the nematode, Nippostrongylus brasiliensis.
    Gastroenterology, 1981, Volume: 81, Issue:6

    Topics: Animals; Carbohydrate Metabolism; Hookworm Infections; Hydrogen; Intestinal Absorption; Malabsorptio

1981
[Chronic diarrhea. New aspects of diagnosis and therapy].
    Fortschritte der Medizin, 1981, Oct-15, Volume: 99, Issue:39

    Topics: Anti-Bacterial Agents; Breath Tests; Charcoal; Cholestyramine Resin; Chronic Disease; Diarrhea; Gluc

1981
Interval breath hydrogen test in glucose-galactose malabsorption.
    European journal of pediatrics, 1981, Volume: 137, Issue:3

    Topics: Air; Female; Galactose; Glucose; Humans; Hydrogen; Infant, Newborn; Malabsorption Syndromes

1981
[Breath hydrogen measurement by our apparatus with a closed system after administration of D-xylose (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1980, Volume: 77, Issue:7

    Topics: Adult; Breath Tests; Humans; Hydrogen; Malabsorption Syndromes; Male; Xylose

1980
Sugar malabsorption in healthy neonates estimated by breath hydrogen.
    Archives of disease in childhood, 1980, Volume: 55, Issue:7

    Topics: Bottle Feeding; Breast Feeding; Breath Tests; Dietary Carbohydrates; Humans; Hydrogen; Infant, Newbo

1980
A new method for the detection of hydrogen in breath and its application to acquired and inborn sugar malabsorption.
    Clinica chimica acta; international journal of clinical chemistry, 1980, Dec-08, Volume: 108, Issue:2

    Topics: Aged; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Female; Gastroi

1980
Malabsorption syndromes including disease of pancreatic and biliary origin.
    Current concepts in nutrition, 1980, Volume: 9

    Topics: Bile Acids and Salts; Breath Tests; Celiac Disease; Diarrhea; Enterobacteriaceae; Exocrine Pancreati

1980
D-xylose hydrogen breath tests compared to absorption kinetics in human patients with and without malabsorption.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:10

    Topics: Administration, Oral; Biopsy; Breath Tests; Diarrhea; Dose-Response Relationship, Drug; Duodenum; Hu

1995
Fructose breath hydrogen tests in infants with chronic non-specific diarrhoea.
    European journal of pediatrics, 1995, Volume: 154, Issue:5

    Topics: Beverages; Breath Tests; Case-Control Studies; Chi-Square Distribution; Child, Preschool; Chronic Di

1995
Colonic fermentation: metabolic and clinical implications.
    The Clinical investigator, 1994, Volume: 72, Issue:10

    Topics: Acetates; Acetic Acid; Anaerobiosis; Animals; Butyrates; Butyric Acid; Cell Division; Colitis, Ulcer

1994
Clinical applicability of shortened D-xylose breath test for diagnosis of intestinal malabsorption.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:11

    Topics: Adolescent; Adult; Aged; Breath Tests; Colonic Diseases, Functional; Female; Humans; Hydrogen; Intes

1994
The possible role of breath methane measurement in detecting carbohydrate malabsorption.
    The Journal of laboratory and clinical medicine, 1994, Volume: 124, Issue:5

    Topics: Adult; Breath Tests; Carbohydrates; Electrolytes; Fasting; Female; Humans; Hydrogen; Lactose; Malabs

1994
Accuracy of breath H2 criteria to detect carbohydrate malabsorption.
    Gastroenterology, 1994, Volume: 107, Issue:1

    Topics: Breath Tests; Carbohydrate Metabolism; Humans; Hydrogen; Malabsorption Syndromes

1994
Chemotherapy-induced lactose intolerance in adults.
    Cancer, 1994, Sep-01, Volume: 74, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bacteria; Breath Tes

1994
Fructose malabsorption in a child with chronic diarrhea.
    Journal of pediatric gastroenterology and nutrition, 1994, Volume: 18, Issue:1

    Topics: Absorption; Biopsy; Child, Preschool; Chronic Disease; Diarrhea; Fructose; Humans; Hydrogen; Intesti

1994
Intestinal bile acid malabsorption in cystic fibrosis.
    Gut, 1993, Volume: 34, Issue:8

    Topics: Adolescent; Adult; Bile Acids and Salts; Breath Tests; Cystic Fibrosis; Feces; Female; Humans; Hydro

1993
Prevalence and consistency of low breath H2 excretion following lactulose ingestion. Possible implications for the clinical use of the H2 breath test.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:11

    Topics: Adult; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Female; Humans; Hydrogen; Lactulose; Ma

1993
Detection of malabsorption of low doses of carbohydrate: accuracy of various breath H2 criteria.
    Gastroenterology, 1993, Volume: 105, Issue:5

    Topics: Adult; Aged; Anti-Bacterial Agents; Breath Tests; Carbohydrate Metabolism; Female; Humans; Hydrogen;

1993
Potential usefulness of hydrogen breath test with D-xylose in clinical management of intestinal malabsorption.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:2

    Topics: Adult; Analysis of Variance; Breath Tests; Colonic Diseases, Functional; Female; Humans; Hydrogen; I

1993
Apple juice malabsorption: fructose or sorbitol?
    Journal of pediatric gastroenterology and nutrition, 1993, Volume: 16, Issue:1

    Topics: Adult; Breath Tests; Child; Child, Preschool; Female; Fructose; Fruit; Humans; Hydrogen; Infant; Mal

1993
Fruit juice and chronic nonspecific diarrhea.
    The Journal of pediatrics, 1993, Volume: 122, Issue:3

    Topics: Breath Tests; Child; Child, Preschool; Chronic Disease; Diarrhea; Fructose; Fruit; Humans; Hydrogen;

1993
Breath hydrogen excretion in patients with alcoholic liver disease--evidence of small intestinal bacterial overgrowth.
    Zeitschrift fur Gastroenterologie, 1993, Volume: 31, Issue:1

    Topics: Adult; Breath Tests; Colony Count, Microbial; Female; Humans; Hydrogen; Intestine, Small; Liver Dise

1993
Congenital sucrase-isomaltase deficiency. Identification of a glutamine to proline substitution that leads to a transport block of sucrase-isomaltase in a pre-Golgi compartment.
    The Journal of clinical investigation, 1996, Feb-01, Volume: 97, Issue:3

    Topics: Amino Acid Sequence; Base Sequence; Biological Transport; Biopsy; Breath Tests; Cell Compartmentatio

1996
Correlation of hydrogen and methane production to rice carbohydrate malabsorption in Burmese (Myanmar) children.
    Journal of pediatric gastroenterology and nutrition, 1996, Volume: 22, Issue:2

    Topics: Adult; Aging; Anthropometry; Body Height; Breath Tests; Child; Child, Preschool; Colon; Dietary Carb

1996
The effect of long-term omeprazole on the glucose-hydrogen breath test in elderly patients.
    Age and ageing, 1997, Volume: 26, Issue:2

    Topics: Aged; Aged, 80 and over; Anthropometry; Anti-Ulcer Agents; Bacteria; Breath Tests; Female; Glucose S

1997
[The H2 breath test].
    Deutsche medizinische Wochenschrift (1946), 1997, Aug-22, Volume: 122, Issue:34-35

    Topics: Breath Tests; Humans; Hydrogen; Lactose Tolerance Test; Malabsorption Syndromes; Sensitivity and Spe

1997
Bowel dysfunction in cystic fibrosis: importance of breath testing.
    Journal of paediatrics and child health, 1998, Volume: 34, Issue:1

    Topics: Breath Tests; Carbohydrate Metabolism; Child; Child, Preschool; Cystic Fibrosis; Digestive System; G

1998
Carbohydrate malabsorption following acarbose administration.
    Diabetic medicine : a journal of the British Diabetic Association, 1998, Volume: 15, Issue:5

    Topics: Acarbose; Adolescent; Adult; Aged; Breath Tests; Diabetes Mellitus, Type 2; Dietary Carbohydrates; E

1998
Fructose malabsorption is associated with early signs of mental depression.
    European journal of medical research, 1998, Jun-17, Volume: 3, Issue:6

    Topics: Adult; Aged; Depression; Female; Fructose; Humans; Hydrogen; Malabsorption Syndromes; Male; Middle A

1998
Fructose malabsorption is associated with decreased plasma tryptophan.
    Advances in experimental medicine and biology, 1999, Volume: 467

    Topics: Adolescent; Adult; Breath Tests; Depression; Female; Fructose; Humans; Hydrogen; Intestinal Absorpti

1999
Evaluation of the rice breath hydrogen test for small intestinal bacterial overgrowth.
    The American journal of gastroenterology, 2000, Volume: 95, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Colony Count, Microbial; Diarrhea; Enterob

2000
Coincidental malabsorption of lactose, fructose, and sorbitol ingested at low doses is not common in normal adults.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:12

    Topics: Adult; Breath Tests; Female; Fructose; Fructose Intolerance; Humans; Hydrogen; Lactose; Lactose Into

2000
Increased serum amylase and lipase in fructose malabsorbers.
    Clinica chimica acta; international journal of clinical chemistry, 2001, Sep-25, Volume: 311, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amylases; Breath Tests; Female; Fructose; Humans; Hydrog

2001
Editorial: Breath tests in gastroenterology.
    Lancet (London, England), 1975, Jul-26, Volume: 2, Issue:7926

    Topics: Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Humans; Hydrogen; Intestinal Absorption; Intesti

1975
Breath hydrogen concentrations after oral lactose and lactulose in tropical malabsorption and adult hypolactasia.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1978, Volume: 72, Issue:3

    Topics: Adult; beta-Galactosidase; Breath Tests; Disaccharides; Female; Galactosidases; Humans; Hydrogen; La

1978
Methanogenesis in the gastrointestinal tract of ruminants and man.
    Antonie van Leeuwenhoek, 1979, Volume: 45, Issue:3

    Topics: Animals; Carbohydrate Metabolism; Cattle; Colon; Ethanol; Euryarchaeota; Fatty Acids, Volatile; Huma

1979
Sucrose malabsorption in children: noninvasive diagnosis by interval breath hydrogen determination.
    The Journal of pediatrics, 1978, Volume: 93, Issue:1

    Topics: Adolescent; Breath Tests; Child; Child, Preschool; Chromatography, Gas; Humans; Hydrogen; Infant; Ma

1978
Breath tests.
    Clinics in gastroenterology, 1978, Volume: 7, Issue:2

    Topics: Bile Acids and Salts; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Dietary Carbohydrates; Die

1978
Development of an interval sampling hydrogen (H2) breath test for carbohydrate malabsorption in children: evidence for a circadian pattern of breath H2 concentration.
    Pediatric research, 1978, Volume: 12, Issue:8

    Topics: Anti-Bacterial Agents; Breath Tests; Carbohydrate Metabolism; Child, Preschool; Circadian Rhythm; Hu

1978
An improved method for determining breath H2 as an indicator of carbohydrate malabsorption.
    Analytical biochemistry, 1978, Aug-01, Volume: 88, Issue:2

    Topics: Adult; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Chromatography, Gas; Female; Humans; Hy

1978
Use of breath hydrogen (H2) in the study of carbohydrate absorption.
    The American journal of digestive diseases, 1977, Volume: 22, Issue:4

    Topics: Diarrhea; Dietary Carbohydrates; Feces; Humans; Hydrogen; Intestinal Absorption; Intestines; Malabso

1977
Tests for lactose malabsorption in adults.
    British medical journal, 1975, Jun-28, Volume: 2, Issue:5973

    Topics: Adult; Breath Tests; Chromatography, Gas; Humans; Hydrogen; Intestinal Absorption; Lactose; Malabsor

1975
Quantitative measurement of lactose absorption.
    Gastroenterology, 1976, Volume: 70, Issue:6

    Topics: Carbon Dioxide; Carbon Radioisotopes; Colon; Feces; Humans; Hydrogen; Ileum; Intestinal Absorption;

1976
Malabsorption of different lactose loads in children with human immunodeficiency virus infection.
    Journal of pediatric gastroenterology and nutrition, 1992, Volume: 15, Issue:4

    Topics: Breath Tests; Child; Child, Preschool; HIV Infections; Humans; Hydrogen; Infant; Lactose; Malabsorpt

1992
The diagnosis of small bowel bacterial overgrowth in elderly patients.
    Journal of the American Geriatrics Society, 1992, Volume: 40, Issue:7

    Topics: Aged; Aged, 80 and over; Bacterial Infections; Bacteriological Techniques; Blood Chemical Analysis;

1992
Evaluation of carbohydrate malassimilation and intestinal transit time in cats by measurement of breath hydrogen excretion.
    American journal of veterinary research, 1991, Volume: 52, Issue:7

    Topics: Animals; Breath Tests; Cat Diseases; Cats; Dietary Carbohydrates; Female; Hydrogen; Intestinal Absor

1991
Breath hydrogen excretion or plasma acetate levels during the lactulose tolerance test?
    African journal of medicine and medical sciences, 1991, Volume: 20, Issue:2

    Topics: Acetates; Administration, Oral; Adult; Aged; Breath Tests; Carbohydrates; Evaluation Studies as Topi

1991
Gastrointestinal dysfunction and disaccharide intolerance in children infected with human immunodeficiency virus.
    The Journal of pediatrics, 1991, Volume: 118, Issue:3

    Topics: Breath Tests; Child; Child, Preschool; Diarrhea; Disaccharides; Duodenum; Feces; HIV Infections; Hum

1991
Interval sampling of end-expiratory hydrogen (H2) concentrations to quantify carbohydrate malabsorption by means of lactulose standards.
    Gut, 1990, Volume: 31, Issue:1

    Topics: Adult; Breath Tests; Carbohydrate Metabolism; Disaccharides; Female; Humans; Hydrogen; Lactulose; Ma

1990
Role of fructose-sorbitol malabsorption in the irritable bowel syndrome.
    Gastroenterology, 1990, Volume: 99, Issue:4

    Topics: Adult; Breath Tests; Colonic Diseases, Functional; Female; Fructose; Humans; Hydrogen; Intestinal Ab

1990
Development of hydrogen excretion between feeds in breast and artificially fed full-term normal neonates.
    Australian paediatric journal, 1989, Volume: 25, Issue:2

    Topics: Breast Feeding; Breath Tests; Humans; Hydrogen; Infant Food; Infant, Newborn; Malabsorption Syndrome

1989
Pulmonary excretion of H2 in calves with Cryptosporidium-induced malabsorption.
    Digestive diseases and sciences, 1989, Volume: 34, Issue:9

    Topics: Animals; Breath Tests; Cattle; Cattle Diseases; Cryptosporidiosis; Feces; Hydrogen; Malabsorption Sy

1989
Ileal loss of available carbohydrate in man: comparison of a breath hydrogen method with direct measurement using a human ileostomy model.
    The American journal of gastroenterology, 1986, Volume: 81, Issue:2

    Topics: Adult; Blood Glucose; Breath Tests; Dietary Carbohydrates; Dietary Fiber; Female; Humans; Hydrogen;

1986
Gastrointestinal hypersensitivity to cow's milk protein: the diagnostic value of gut function tests.
    Australian paediatric journal, 1986, Volume: 22, Issue:1

    Topics: beta-Galactosidase; Biopsy; Breath Tests; Child, Preschool; Food Hypersensitivity; Humans; Hydrogen;

1986
The breath hydrogen test: an evaluation.
    Australian paediatric journal, 1988, Volume: 24, Issue:1

    Topics: Breath Tests; Carbohydrates; Child; Humans; Hydrogen; Intestinal Absorption; Malabsorption Syndromes

1988
Starch malabsorption and breath gas excretion in healthy humans consuming low- and high-starch diets.
    Gastroenterology, 1988, Volume: 95, Issue:2

    Topics: Adult; Breath Tests; Colon; Dietary Carbohydrates; Feces; Humans; Hydrogen; Ileum; Intestinal Absorp

1988
Screening tests for enteropathy in children.
    American journal of diseases of children (1960), 1987, Volume: 141, Issue:4

    Topics: Adolescent; Biopsy; Breath Tests; Child; Child, Preschool; Fats; Feces; Female; Humans; Hydrogen; In

1987
Hydrogen breath test in small intestinal malabsorption.
    Acta paediatrica Hungarica, 1987, Volume: 28, Issue:1

    Topics: Adolescent; Breath Tests; Celiac Disease; Child; Child, Preschool; Diagnosis, Differential; Humans;

1987
Use of pulmonary hydrogen gas excretion to detect carbohydrate malabsorption in dogs.
    Journal of the American Veterinary Medical Association, 1986, Sep-15, Volume: 189, Issue:6

    Topics: Animals; Carbohydrate Metabolism; Chronic Disease; Diarrhea; Dog Diseases; Dogs; Exocrine Pancreatic

1986
[Expiratory H2 studies in absorption disorders of the small intestine].
    Orvosi hetilap, 1986, Apr-20, Volume: 127, Issue:16

    Topics: Biopsy; Celiac Disease; Child; Child, Preschool; Humans; Hydrogen; Intestine, Small; Lactose Intoler

1986
Evaluation of intestinal carbohydrate malabsorption in the dog by pulmonary hydrogen gas excretion.
    American journal of veterinary research, 1986, Volume: 47, Issue:6

    Topics: Animals; Breath Tests; Dietary Carbohydrates; Dogs; Female; Hydrogen; Intestinal Absorption; Lactulo

1986
[Diagnosis of contaminated small bowel syndrome, causing severe malabsorption, by H2 breath analysis].
    Orvosi hetilap, 1986, Jul-27, Volume: 127, Issue:30

    Topics: Bacterial Infections; Breath Tests; Humans; Hydrogen; Hydrogen-Ion Concentration; Intestinal Disease

1986
Carbohydrate malabsorption in black and Hispanic dialysis patients.
    The American journal of gastroenterology, 1986, Volume: 81, Issue:8

    Topics: Adult; Aged; Black or African American; Breath Tests; Dietary Carbohydrates; Female; Fructose; Hispa

1986
Breath hydrogen concentration and small intestinal malabsorption in calves.
    American journal of veterinary research, 1986, Volume: 47, Issue:9

    Topics: Animals; Breath Tests; Carbohydrate Metabolism; Cattle; Cattle Diseases; Hydrogen; Malabsorption Syn

1986
Comments on carbohydrate malabsorption.
    Journal of the American Veterinary Medical Association, 1987, Jan-01, Volume: 190, Issue:1

    Topics: Animals; Breath Tests; Carbohydrate Metabolism; Dog Diseases; Dogs; Hydrogen; Malabsorption Syndrome

1987
Limited efficacy of early postoperative jejunal feeding.
    American journal of surgery, 1985, Volume: 150, Issue:1

    Topics: Breath Tests; Diarrhea; Enteral Nutrition; Food Additives; Food, Formulated; Gastrointestinal Diseas

1985
Apple juice. An unappreciated cause of chronic diarrhea.
    American journal of diseases of children (1960), 1985, Volume: 139, Issue:5

    Topics: Breath Tests; Carbohydrates; Child, Preschool; Chromatography, Gas; Chronic Disease; Diarrhea; Fruit

1985
The daytime breath hydrogen profile: technical aspects and normal pattern.
    Clinica chimica acta; international journal of clinical chemistry, 1985, Apr-30, Volume: 147, Issue:3

    Topics: Adolescent; Breath Tests; Carbohydrate Metabolism; Child; Child, Preschool; Humans; Hydrogen; Malabs

1985
[Acid fermentation and hydrogen production by colonic flora in a case of malabsorption of glucose and galactose].
    Gastroenterologie clinique et biologique, 1985, Volume: 9, Issue:11

    Topics: Colon; Female; Galactose; Glucose; Humans; Hydrogen; Infant, Newborn; Lactates; Malabsorption Syndro

1985
Hydrogen (H2) catabolism in the colon of the rat.
    The Journal of laboratory and clinical medicine, 1974, Volume: 84, Issue:2

    Topics: Animals; Bacteria; Bile Acids and Salts; Carbon Monoxide; Cecum; Chromatography, Gas; Colon; Depress

1974
Effect of phenformin on carbohydrate absorption in man.
    Diabetes, 1974, Volume: 23, Issue:8

    Topics: Adult; Bacteria; Chromatography, Gas; Colon; Female; Fermentation; Glucose; Glucose Tolerance Test;

1974
Use of pulmonary hydrogen (H 2 ) measurements to quantitate carbohydrate absorption. Study of partially gastrectomized patients.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:5

    Topics: Carbohydrate Metabolism; Disaccharides; Fructose; Galactose; Gastrectomy; Humans; Hydrogen; Intestin

1972