hydrogen has been researched along with Irritable Bowel Syndrome in 71 studies
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.
Irritable Bowel Syndrome: A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dietary fructans exacerbate symptoms in some, but not all, adults with irritable bowel syndrome (IBS)." | 9.27 | Fructans Exacerbate Symptoms in a Subset of Children With Irritable Bowel Syndrome. ( Ali, A; Chumpitazi, BP; Elsaadi, A; McMeans, AR; Orlando, S; Shulman, RJ; Vaughan, A, 2018) |
| "Irritable bowel syndrome patients with diarrhea (IBS-D) and healthy volunteers (HVs) were enrolled and received a 10 g, 20 g, or 40 g dose lactose hydrogen breath test (LHBT) in a randomized, double-blinded, controlled trial." | 9.20 | Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea. ( Chu, H; Dai, N; Fox, M; Fried, M; Long, YQ; Pohl, D; Yang, JF; Zheng, X, 2015) |
| "Whether hydrogen and methane gas produced during lactulose breath test (LBT) are associated with symptoms of irritable bowel syndrome (IBS) is not determined." | 9.17 | Association between symptoms of irritable bowel syndrome and methane and hydrogen on lactulose breath test. ( Choi, HS; Hahm, JS; Jun, DW; Koh, DH; Lee, HL; Lee, KN; Lee, OY; Lee, SP; Sohn, W; Yoon, BC, 2013) |
| "Lactose intolerance is a frequent gastrointestinal disease affecting 47% of the Eastern European population." | 7.96 | The role of small intestinal bacterial overgrowth and false positive diagnosis of lactose intolerance in southwest Hungary-A retrospective observational study. ( Czimmer, J; Gede, N; Hegyi, P; Pécsi, D; Varjú, P; Ystad, B, 2020) |
| "Symptoms associated with lactose intolerance (LI) and diarrhea-predominant irritable bowel syndrome (IBS-D) are almost the same." | 7.85 | Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China. ( Chen, M; Gong, X; Wang, Y; Xiong, L, 2017) |
| "Patients with irritable bowel syndrome (IBS) can be assigned to groups with different gastrointestinal (GI) symptoms based on results from a combined nutrient and lactulose challenge." | 7.83 | Lactulose Challenge Determines Visceral Sensitivity and Severity of Symptoms in Patients With Irritable Bowel Syndrome. ( Brazeilles, R; Derrien, M; Guyonnet, D; Le Nevé, B; Ohman, L; Simrén, M; Tap, J; Törnblom, H, 2016) |
| "Diarrhea-predominant irritable bowel syndrome patients with abnormal lactose HBTs ingested a test meal containing (99m) Tc and lactose." | 7.81 | Small intestinal bacterial overgrowth as an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhea-predominant irritable bowel syndrome in Asia. ( Chen, M; Gong, X; Li, W; Wang, Y; Xiong, L; Zhang, X, 2015) |
| "Among irritable bowel syndrome (IBS) patients, breath methane producers overwhelmingly have constipation predominance (C-IBS)." | 7.78 | Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath. ( Chang, C; Deepinder, F; Gunsalus, R; Hwang, L; Kim, G; Morales, W; Pimentel, M; Weitsman, S, 2012) |
| "Methane excretion is clearly associated with alterations in intestinal motility, particularly favouring those with constipation." | 7.78 | Reassessment of the role of methane production between irritable bowel syndrome and functional constipation. ( Bruzzone, L; Dulbecco, P; Furnari, M; Gemignani, L; Giannini, EG; Moscatelli, A; Savarino, E; Savarino, V; Zentilin, P, 2012) |
| " The present study was designed to evaluate the effect of predominant fasting methane CH(4) or H(2) production on the outcome of lactose HBT, in a large, homogeneous series of adult patients with irritable bowel syndrome (IBS)." | 7.72 | Effect of predominant methanogenic flora on the outcome of lactose breath test in irritable bowel syndrome patients. ( Camillo, MD; Caprilli, R; Marinaro, V; Vernia, P, 2003) |
| "An abnormal lactulose breath test is more common in fibromyalgia than IBS." | 7.72 | A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing. ( Chow, E; Hallegua, D; Kong, Y; Lin, HC; Park, S; Pimentel, M; Wallace, D, 2004) |
| "Dietary fructans exacerbate symptoms in some, but not all, adults with irritable bowel syndrome (IBS)." | 5.27 | Fructans Exacerbate Symptoms in a Subset of Children With Irritable Bowel Syndrome. ( Ali, A; Chumpitazi, BP; Elsaadi, A; McMeans, AR; Orlando, S; Shulman, RJ; Vaughan, A, 2018) |
| " In children with IBS, lactulose breath test hydrogen and methane production did not, however, correlate with abdominal pain, IBS subtype, or psychosocial distress." | 5.24 | Lactulose Breath Test Gas Production in Childhood IBS Is Associated With Intestinal Transit and Bowel Movement Frequency. ( Chumpitazi, BP; Shulman, RJ; Weidler, EM, 2017) |
| "Previous observations suggested that an early rise in breath hydrogen after lactulose (ERBHAL) may identify patients with irritable bowel syndrome (IBS) likely to respond to probiotics." | 5.20 | Poor predictive value of breath hydrogen response for probiotic effects in IBS. ( Barrett, JS; Chung, AR; Garg, M; Gibson, PR; Philpott, H; van Langenberg, D; Yao, CK, 2015) |
| "Irritable bowel syndrome patients with diarrhea (IBS-D) and healthy volunteers (HVs) were enrolled and received a 10 g, 20 g, or 40 g dose lactose hydrogen breath test (LHBT) in a randomized, double-blinded, controlled trial." | 5.20 | Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea. ( Chu, H; Dai, N; Fox, M; Fried, M; Long, YQ; Pohl, D; Yang, JF; Zheng, X, 2015) |
| "Whether hydrogen and methane gas produced during lactulose breath test (LBT) are associated with symptoms of irritable bowel syndrome (IBS) is not determined." | 5.17 | Association between symptoms of irritable bowel syndrome and methane and hydrogen on lactulose breath test. ( Choi, HS; Hahm, JS; Jun, DW; Koh, DH; Lee, HL; Lee, KN; Lee, OY; Lee, SP; Sohn, W; Yoon, BC, 2013) |
| "The determination of breath ammonia may be useful as biomarker of dysbiosis in patients with irritable bowel syndrome, especially in questionable results of hydrogen breath test." | 4.12 | The clinical value of breath ammonia determination in patients with irritable bowel syndrome. ( Błońska, A; Chojnacki, C; Chojnacki, M; Konrad, P; Mędrek-Socha, M, 2022) |
| "Lactose intolerance is a frequent gastrointestinal disease affecting 47% of the Eastern European population." | 3.96 | The role of small intestinal bacterial overgrowth and false positive diagnosis of lactose intolerance in southwest Hungary-A retrospective observational study. ( Czimmer, J; Gede, N; Hegyi, P; Pécsi, D; Varjú, P; Ystad, B, 2020) |
| " In this study, we aimed to analyze the significance of a combined lactulose hydrogen breath test (LHBT) and liquid meal, yet representing a standardized test in irritable bowel syndrome (IBS), in FD." | 3.91 | Differentiation of functional gastrointestinal disorders from healthy volunteers by lactulose hydrogen breath test and test meal. ( Bütikofer, S; Fried, M; Giezendanner, S; Murray, F; Pohl, D; Runggaldier, D; Schindler, V; Schnurre, L; Zweig, A, 2019) |
| "Patients with irritable bowel syndrome (IBS) have an increased response of postprandial symptoms to a combined lactulose nutrient challenge test, compared with healthy volunteers." | 3.88 | Functional Dyspepsia and Severity of Psychologic Symptoms Associate With Postprandial Symptoms in Patients With Irritable Bowel Syndrome. ( Le Nevé, B; Pohl, D; Simrén, M; Tack, J; Törnblom, H; Van Oudenhove, L, 2018) |
| "Symptoms associated with lactose intolerance (LI) and diarrhea-predominant irritable bowel syndrome (IBS-D) are almost the same." | 3.85 | Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China. ( Chen, M; Gong, X; Wang, Y; Xiong, L, 2017) |
| "Lactulose breath test graphs of 561 patients of all irritable bowel syndrome subtypes were grouped into categories based on their hydrogen + methane levels with respect to time." | 3.83 | Predicting a Response to Antibiotics in Patients with the Irritable Bowel Syndrome. ( Adler, M; Dhingra, S; Guttermuth, C; Kasir, R; Lee, A; Zakko, P; Zakko, S, 2016) |
| "Patients with irritable bowel syndrome (IBS) can be assigned to groups with different gastrointestinal (GI) symptoms based on results from a combined nutrient and lactulose challenge." | 3.83 | Lactulose Challenge Determines Visceral Sensitivity and Severity of Symptoms in Patients With Irritable Bowel Syndrome. ( Brazeilles, R; Derrien, M; Guyonnet, D; Le Nevé, B; Ohman, L; Simrén, M; Tap, J; Törnblom, H, 2016) |
| "Diarrhea-predominant irritable bowel syndrome patients with abnormal lactose HBTs ingested a test meal containing (99m) Tc and lactose." | 3.81 | Small intestinal bacterial overgrowth as an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhea-predominant irritable bowel syndrome in Asia. ( Chen, M; Gong, X; Li, W; Wang, Y; Xiong, L; Zhang, X, 2015) |
| "Lactose malabsorption (LM), diagnosed currently using lactose hydrogen breath and tolerance tests (LHBT, LTT) with a high, nonphysiological dose (50-g), may mimic irritable bowel syndrome (IBS)." | 3.79 | Lactose malabsorption diagnosed by 50-g dose is inferior to assess clinical intolerance and to predict response to milk withdrawal than 25-g dose in an endemic area. ( Ghoshal, UC; Kumar, S; Misra, A; Mittal, B, 2013) |
| "Among irritable bowel syndrome (IBS) patients, breath methane producers overwhelmingly have constipation predominance (C-IBS)." | 3.78 | Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath. ( Chang, C; Deepinder, F; Gunsalus, R; Hwang, L; Kim, G; Morales, W; Pimentel, M; Weitsman, S, 2012) |
| "Methane excretion is clearly associated with alterations in intestinal motility, particularly favouring those with constipation." | 3.78 | Reassessment of the role of methane production between irritable bowel syndrome and functional constipation. ( Bruzzone, L; Dulbecco, P; Furnari, M; Gemignani, L; Giannini, EG; Moscatelli, A; Savarino, E; Savarino, V; Zentilin, P, 2012) |
| "Gastrointestinal complaints in patients with persistent or cleared giardiasis were unrelated to hydrogen breath excretion after lactulose challenge." | 3.74 | Lactulose breath test results in patients with persistent abdominal symptoms following Giardia lamblia infection. ( Berstad, A; Hausken, T; Morken, MH; Nysaeter, G; Strand, EA, 2008) |
| "OBJECTIVES Recent reports suggest bacterial overgrowth is commonly associated with irritable bowel syndrome (IBS) when diagnosed using the lactulose hydrogen breath test (LHBT)." | 3.73 | Detection of bacterial overgrowth in IBS using the lactulose H2 breath test: comparison with 14C-D-xylose and healthy controls. ( Vanner, SJ; Walters, B, 2005) |
| " The present study was designed to evaluate the effect of predominant fasting methane CH(4) or H(2) production on the outcome of lactose HBT, in a large, homogeneous series of adult patients with irritable bowel syndrome (IBS)." | 3.72 | Effect of predominant methanogenic flora on the outcome of lactose breath test in irritable bowel syndrome patients. ( Camillo, MD; Caprilli, R; Marinaro, V; Vernia, P, 2003) |
| "We have previously shown that methane on lactulose breath test (LBT) is highly associated with constipation in IBS and that methane gas itself slows small bowel transit in dogs." | 3.72 | IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen. ( Kong, Y; Park, S; Pimentel, M, 2004) |
| "An abnormal lactulose breath test is more common in fibromyalgia than IBS." | 3.72 | A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing. ( Chow, E; Hallegua, D; Kong, Y; Lin, HC; Park, S; Pimentel, M; Wallace, D, 2004) |
| "Reduction of short-chain poorly absorbed carbohydrates (FODMAPs) in the diet reduces symptoms of irritable bowel syndrome (IBS)." | 2.75 | Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome. ( Barrett, JS; Biesiekierski, JR; Gibson, PR; Irving, PM; Mitchell, SB; Muir, JG; Ong, DK; Shepherd, SJ; Smith, S, 2010) |
| "Hydrogen was detected more frequently in patients with diarrhea-predominant IBS (OR, 8; 95% CI, 1." | 1.36 | Small intestinal bacterial overgrowth in irritable bowel syndrome: are there any predictors? ( McCallum, RW; Reddymasu, SC; Sostarich, S, 2010) |
| "The lactose HBT result was abnormal in 78." | 1.36 | Frequency of lactose malabsorption among healthy southern and northern Indian populations by genetic analysis and lactose hydrogen breath and tolerance tests. ( Babu, J; Babu, P; Ghoshal, UC; Kumar, S; Prasad, JH, 2010) |
| "Lactose malabsorption was present in 27/31 (87%) patients with CFD and 29/32 (91%) healthy controls (P = 0." | 1.36 | Lactose intolerance in patients with chronic functional diarrhoea: the role of small intestinal bacterial overgrowth. ( Chu, H; Cong, Y; Dai, N; Fox, M; Fried, M; Shang, Y; Zhao, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (15.49) | 29.6817 |
| 2010's | 45 (63.38) | 24.3611 |
| 2020's | 15 (21.13) | 2.80 |
| Authors | Studies |
|---|---|
| Schindler, V | 3 |
| Hente, J | 2 |
| Murray, FR | 2 |
| Hüllner, M | 1 |
| Becker, AS | 1 |
| Giezendanner, S | 3 |
| Schnurre, L | 2 |
| Bordier, V | 2 |
| Pohl, D | 5 |
| Muratore, A | 1 |
| Shah, ED | 1 |
| Chan, WW | 1 |
| Algera, JP | 1 |
| Colomier, E | 1 |
| Melchior, C | 1 |
| Hreinsson, JP | 1 |
| Midenfjord, I | 1 |
| Clevers, E | 1 |
| Simrén, M | 6 |
| Törnblom, H | 6 |
| Wang, T | 1 |
| van Dijk, L | 1 |
| Rijnaarts, I | 1 |
| Hermes, GDA | 1 |
| de Roos, NM | 1 |
| Witteman, BJM | 1 |
| de Wit, NJW | 1 |
| Govers, C | 1 |
| Smidt, H | 1 |
| Zoetendal, EG | 1 |
| Sikander, A | 1 |
| Rana, SV | 1 |
| Sinha, SK | 1 |
| Prasad, KK | 1 |
| Arora, SK | 1 |
| Bustos Fernández, LM | 2 |
| Man, F | 1 |
| Lasa, JS | 1 |
| Chojnacki, C | 2 |
| Błońska, A | 3 |
| Mędrek-Socha, M | 2 |
| Chojnacki, M | 1 |
| Konrad, P | 2 |
| Ghoshal, UC | 5 |
| Ghoshal, U | 2 |
| Shah, A | 1 |
| Holtmann, G | 1 |
| Rezaie, A | 1 |
| Varjú, P | 1 |
| Ystad, B | 1 |
| Gede, N | 1 |
| Hegyi, P | 1 |
| Pécsi, D | 1 |
| Czimmer, J | 1 |
| Ostojic, SM | 1 |
| Essa, H | 1 |
| Hamdy, S | 1 |
| Green, D | 1 |
| Lal, S | 1 |
| McLaughlin, J | 1 |
| Hoffmann, S | 1 |
| Leitao, E | 1 |
| Paine, P | 1 |
| Tap, J | 4 |
| Störsrud, S | 3 |
| Le Nevé, B | 5 |
| Cotillard, A | 1 |
| Pons, N | 1 |
| Doré, J | 2 |
| Öhman, L | 4 |
| Derrien, M | 4 |
| Van Oudenhove, L | 2 |
| Buehler, J | 1 |
| Gunn, D | 1 |
| Abbas, Z | 1 |
| Harris, HC | 1 |
| Major, G | 2 |
| Hoad, C | 1 |
| Gowland, P | 2 |
| Marciani, L | 2 |
| Gill, SK | 1 |
| Warren, FJ | 1 |
| Rossi, M | 1 |
| Remes-Troche, JM | 1 |
| Whelan, K | 2 |
| Spiller, RC | 1 |
| Jung, SE | 1 |
| Joo, NS | 2 |
| Han, KS | 1 |
| Kim, KN | 2 |
| Chumpitazi, BP | 2 |
| McMeans, AR | 1 |
| Vaughan, A | 1 |
| Ali, A | 1 |
| Orlando, S | 1 |
| Elsaadi, A | 1 |
| Shulman, RJ | 2 |
| Xiong, L | 2 |
| Wang, Y | 2 |
| Gong, X | 2 |
| Chen, M | 2 |
| Chen, AGY | 1 |
| Offereins, MSL | 1 |
| Mulder, CJ | 1 |
| Frampton, CM | 1 |
| Gearry, RB | 1 |
| Tack, J | 1 |
| Bütikofer, S | 1 |
| Murray, F | 1 |
| Runggaldier, D | 1 |
| Zweig, A | 1 |
| Fried, M | 3 |
| Harris, LA | 1 |
| Brazeilles, R | 3 |
| Cools Portier, S | 1 |
| Guyonnet, D | 2 |
| Chojnacki, J | 1 |
| Mikulska, P | 1 |
| Kumar, S | 2 |
| Misra, A | 3 |
| Mittal, B | 1 |
| Lee, KN | 1 |
| Lee, OY | 1 |
| Koh, DH | 1 |
| Sohn, W | 1 |
| Lee, SP | 1 |
| Jun, DW | 1 |
| Lee, HL | 1 |
| Yoon, BC | 1 |
| Choi, HS | 1 |
| Hahm, JS | 1 |
| Berg, LK | 1 |
| Fagerli, E | 1 |
| Martinussen, M | 1 |
| Myhre, AO | 1 |
| Florholmen, J | 1 |
| Goll, R | 1 |
| Staudacher, HM | 1 |
| Irving, PM | 2 |
| Lomer, MC | 1 |
| Srivastava, D | 2 |
| Łokieć, K | 1 |
| Klupińska, G | 1 |
| Walecka-Kapica, E | 1 |
| Sharma, A | 1 |
| Verma, A | 1 |
| Korterink, JJ | 1 |
| Benninga, MA | 1 |
| van Wering, HM | 1 |
| Deckers-Kocken, JM | 1 |
| Li, W | 1 |
| Zhang, X | 1 |
| Di Stefano, M | 1 |
| Mengoli, C | 1 |
| Bergonzi, M | 1 |
| Klersy, C | 1 |
| Pagani, E | 1 |
| Miceli, E | 1 |
| Corazza, GR | 1 |
| Yao, CK | 1 |
| Barrett, JS | 3 |
| Philpott, H | 1 |
| Chung, AR | 1 |
| van Langenberg, D | 1 |
| Garg, M | 1 |
| Gibson, PR | 3 |
| Yang, JF | 1 |
| Fox, M | 2 |
| Chu, H | 2 |
| Zheng, X | 1 |
| Long, YQ | 1 |
| Dai, N | 2 |
| Kasir, R | 1 |
| Zakko, S | 1 |
| Zakko, P | 1 |
| Adler, M | 1 |
| Lee, A | 1 |
| Dhingra, S | 1 |
| Guttermuth, C | 1 |
| Pimentel, M | 5 |
| Long, SK | 1 |
| Di Palma, JA | 1 |
| Weidler, EM | 1 |
| Tuck, CJ | 1 |
| Ross, LA | 1 |
| Muir, JG | 2 |
| Cools-Portier, S | 1 |
| Pritchard, S | 1 |
| Murray, K | 1 |
| Alappadan, JP | 1 |
| Hoad, CL | 1 |
| Spiller, R | 1 |
| Lembcke, B | 1 |
| Law, D | 1 |
| Babu, J | 1 |
| Babu, P | 1 |
| Prasad, JH | 1 |
| Lombardo, L | 1 |
| Foti, M | 1 |
| Ruggia, O | 1 |
| Chiecchio, A | 1 |
| Zhao, J | 1 |
| Cong, Y | 1 |
| Shang, Y | 1 |
| Reddymasu, SC | 1 |
| Sostarich, S | 1 |
| McCallum, RW | 1 |
| Chey, WD | 1 |
| Spiegel, B | 1 |
| Gwee, KA | 1 |
| Ong, DK | 1 |
| Mitchell, SB | 1 |
| Shepherd, SJ | 1 |
| Biesiekierski, JR | 1 |
| Smith, S | 1 |
| Ford, AC | 1 |
| Jones, HF | 1 |
| Davidson, GP | 1 |
| Brooks, DA | 1 |
| Butler, RN | 1 |
| Petrone, P | 1 |
| Sarkisyan, G | 1 |
| Fernández, M | 1 |
| Coloma, E | 1 |
| Akopian, G | 1 |
| Ortega, A | 1 |
| Kaufman, HS | 1 |
| Kim, EJ | 1 |
| Paik, CN | 1 |
| Chung, WC | 1 |
| Lee, KM | 1 |
| Yang, JM | 1 |
| Choi, MG | 1 |
| Kim, KM | 1 |
| Kim, BT | 1 |
| Lee, DJ | 1 |
| Park, SB | 1 |
| Kim, YS | 1 |
| Kim, G | 1 |
| Deepinder, F | 1 |
| Morales, W | 1 |
| Hwang, L | 1 |
| Weitsman, S | 1 |
| Chang, C | 1 |
| Gunsalus, R | 1 |
| Furnari, M | 1 |
| Savarino, E | 1 |
| Bruzzone, L | 1 |
| Moscatelli, A | 1 |
| Gemignani, L | 1 |
| Giannini, EG | 1 |
| Zentilin, P | 1 |
| Dulbecco, P | 1 |
| Savarino, V | 1 |
| Dima, G | 2 |
| Peralta, D | 2 |
| Novillo, A | 1 |
| Lasa, J | 1 |
| Besasso, H | 2 |
| Soifer, L | 1 |
| Vernia, P | 2 |
| Camillo, MD | 1 |
| Marinaro, V | 2 |
| Caprilli, R | 2 |
| Kong, Y | 2 |
| Park, S | 2 |
| Wallace, D | 1 |
| Hallegua, D | 1 |
| Chow, E | 1 |
| Lin, HC | 1 |
| Argnani, F | 1 |
| Di Camillo, M | 1 |
| Dear, KL | 1 |
| Elia, M | 1 |
| Hunter, JO | 1 |
| Walters, B | 1 |
| Vanner, SJ | 1 |
| Lupascu, A | 1 |
| Gabrielli, M | 1 |
| Lauritano, EC | 1 |
| Scarpellini, E | 1 |
| Santoliquido, A | 1 |
| Cammarota, G | 1 |
| Flore, R | 1 |
| Tondi, P | 1 |
| Pola, P | 1 |
| Gasbarrini, G | 1 |
| Gasbarrini, A | 1 |
| Soifer, LO | 1 |
| Iantorno, G | 1 |
| Soifer, G | 1 |
| Morken, MH | 2 |
| Berstad, AE | 1 |
| Nysaeter, G | 2 |
| Berstad, A | 2 |
| Strand, EA | 1 |
| Hausken, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Association Between GI Microbiota, Low-grade Inflammation and Classical Pathophysiological Factors in Patients With Irritable Bowel Syndrome (IBS) and Effect of the Consumption of Activia on GI Symptoms Provoked by a Lactulose Challenge Test in IBS Patien[NCT01252550] | 100 participants (Actual) | Interventional | 2010-05-31 | Completed | |||
| Effect of Modified Cellulose on Colonic Fermentation of Inulin (COCOA2)[NCT05911347] | 30 participants (Anticipated) | Interventional | 2023-05-09 | Recruiting | |||
| Effect of Rate Of Delivery on Colonic Fermentation of inuliN (EON)[NCT05619341] | 18 participants (Anticipated) | Interventional | 2022-10-28 | Recruiting | |||
| Effects of Fibre on Intestinal Volume and Gas in Irritable Bowel Syndrome[NCT03265002] | 19 participants (Actual) | Interventional | 2018-03-08 | Completed | |||
| Intestinal Microbiome Fructan Metabolism and Symptom Generation in Childhood IBS[NCT02842281] | 55 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| Effect of Physical Form of Apples on Gastrointestinal Function and Satiety: a MRI Study[NCT03714464] | 31 participants (Actual) | Interventional | 2016-02-29 | Completed | |||
| The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population[NCT01286597] | 3,000 participants (Anticipated) | Interventional | 2011-01-31 | Recruiting | |||
| Crossover Trial of Gluten and Gluten With Amylase-trypsin Inhibitors as Triggers of Gastrointestinal Symptoms in Patients With Irritable Bowel Syndrome[NCT03664531] | 34 participants (Anticipated) | Interventional | 2019-01-01 | Recruiting | |||
| Fructose and Fructans and Irritable Bowel Syndrome: MRI Study of Underlying Mechanisms[NCT01776853] | 69 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Retrospective Analysis of Treatment Outcomes in Patients With Bacterial Overgrowth Syndrome Diagnosed by D-Xylose Breath Testing[NCT01324895] | 944 participants (Actual) | Observational | 2010-08-31 | Completed | |||
| Randomized Controlled Trial of Food Elimination Based on IgG Antibodies for Treatment of Functional Gastrointestinal Diseases (FGIDs) in Children[NCT02565355] | 60 participants (Actual) | Interventional | 2015-09-30 | Completed | |||
| Effects of FODMAPs (Fermentable Oligo-, Di-, and Mono-saccharides, And Polyols) on Small Bowel Water Content: an MRI Study[NCT01459406] | 17 participants (Actual) | Interventional | 2011-10-31 | Completed | |||
| A Prospective, Randomized, Investigator Blinded, Controlled Trial to Evaluate the Effectiveness of Dietary Modification in Patients With Functional Dyspepsia[NCT02863822] | 0 participants (Actual) | Interventional | 2016-09-30 | Withdrawn (stopped due to no patients enrolled) | |||
| Evaluation of the Efficacy and Safety of Single, Daily Oral Doses of SYN-010 Compared to Placebo in Adult Patients With Irritable Bowel Syndrome With Constipation (EASE-DO)[NCT03763175] | Phase 2 | 59 participants (Actual) | Interventional | 2018-12-24 | Terminated (stopped due to Interim Futility Analysis) | ||
| Evaluation of the Efficacy and Safety of Rifaximin in Combination With N-acetylcysteine (NAC) in Adult Patients With Irritable Bowel Syndrome With Diarrhea[NCT04557215] | Phase 1/Phase 2 | 45 participants (Actual) | Interventional | 2020-11-13 | Completed | ||
| Effects of Rifaximin on Visceral Hypersensitivity in Irritable Bowel Syndrome[NCT03462966] | Phase 2 | 4 participants (Actual) | Interventional | 2018-07-01 | Terminated (stopped due to recruitment challenges) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in exhaled methane level as a potential predictor of constipation improvement will be evaluated by comparing single-point breath tests pre- and post-treatment. (NCT03763175)
Timeframe: After completing course of SYN-010
| Intervention | particles per million (Mean) |
|---|---|
| SYN-010 21 mg | -22.623 |
| SYN-010 42 mg | -4.785 |
| Placebo | -10.081 |
Subjects will record their daily bowel movements throughout the duration of the study. Change in weekly average number of CSBMs will be evaluated by comparing reported values pre- and post-treatment. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010
| Intervention | Weekly average CSBMs (Least Squares Mean) |
|---|---|
| SYN-010 21 mg | 1.53 |
| SYN-010 42 mg | 0.32 |
| Placebo | 0.51 |
Change in exhaled methane level as a potential predictor of constipation improvement will be evaluated by comparing lactulose breath tests pre- and post-treatment. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010
| Intervention | particles per million * min (Mean) |
|---|---|
| SYN-010 21 mg | -18.678 |
| SYN-010 42 mg | -20.137 |
| Placebo | -39.199 |
An overall abdominal pain intensity responder is defined as a patient with a weekly abdominal pain intensity response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly response abdominal pain intensity response is defined as a decrease in the patient's weekly average score for worst abdominal pain in the past 24 hours of at least 30% compared to baseline, with stool frequency unchanged or improved compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010
| Intervention | Participants (Count of Participants) |
|---|---|
| SYN-010 21 mg | 4 |
| SYN-010 42 mg | 4 |
| Placebo | 7 |
An overall bloating responder is defined as a patient with a weekly bloating response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly bloating response is defined as a weekly average bloating score of at least 30% improvement compared to baseline, with stool frequency unchanged or improved compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010
| Intervention | Participants (Count of Participants) |
|---|---|
| SYN-010 21 mg | 3 |
| SYN-010 42 mg | 3 |
| Placebo | 1 |
An overall 12-week responder is defined as a patient with a weekly response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly response is defined as a decrease in the patient's weekly average score for worst abdominal pain in the past 24 hours of at least 30% compared to baseline and a stool frequency increase of 1 or more CSBMs per week compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010
| Intervention | Participants (Count of Participants) |
|---|---|
| SYN-010 21 mg | 1 |
| SYN-010 42 mg | 2 |
| Placebo | 6 |
An overall stool frequency responder is defined as a patient with a weekly stool frequency response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly stool frequency response is defined as a stool frequency increase of 1 or more CSBMs per week compared with baseline, with abdominal pain unchanged or improved compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010
| Intervention | Participants (Count of Participants) |
|---|---|
| SYN-010 21 mg | 4 |
| SYN-010 42 mg | 6 |
| Placebo | 9 |
Subjects will record their use of rescue medication throughout the study period. Proportion of patients using rescue medication after completing the 12-week course of treatment will be compared to those reporting usage at baseline screening period. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010
| Intervention | Participants (Count of Participants) |
|---|---|
| SYN-010 21 mg | 9 |
| SYN-010 42 mg | 11 |
| Placebo | 8 |
Outcome will be assessed by evaluating proportion of patients reporting adequate relief pre- and post-treatment on validated questionnaire. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010
| Intervention | Participants (Count of Participants) |
|---|---|
| SYN-010 21 mg | 1 |
| SYN-010 42 mg | 2 |
| Placebo | 6 |
"Change in severity of abdominal pain from baseline, as determined from weekly average visual analog scale (VAS) scores, relative to Rifaximin alone. VAS scores allows subject to choose 0 for no pain to 100 pain as bad as it could possibly be.~The Visual Analogue Scale (VAS) measures pain intensity. The VAS consists of a 10cm line, with two end points representing 0 no pain and 100 pain as bad as it could possibly be~The change between two time points is reported baseline and 4 weeks after cessation of treatment (at 6 weeks)" (NCT04557215)
Timeframe: value at 6 weeks minus value at baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Rifaximin 550 mg | -5.43 |
| Rifaximin 200 mg + Placebo | -8.90 |
| Rifaximin 200 mg Plus N-acetylcysteine (NAC) 600 mg Days | -5.59 |
"Change in stool form from baseline, as determined from stool diary data comparing Rifaximin alone vs rifaximin and NAC~The Bristol Stool Chart, the minimum value is 1 (means constipation) and maximum value is 7 (means diarrhea).~The change between two time points is reported baseline and 4 weeks after cessation of treatment (at 6 weeks)" (NCT04557215)
Timeframe: value at 6 weeks minus value at baseline
| Intervention | score on a scale (Mean) |
|---|---|
| Rifaximin 550 mg | -0.26 |
| Rifaximin 200 mg + Placebo | -0.45 |
| Rifaximin 200 mg Plus N-acetylcysteine (NAC) 600 mg Days | -0.49 |
"Change in stool frequency from baseline, as determined from diary data comparing Rifaximin alone vs Rifaximin and NAC~determined from daily stool diary data~The change in bowel movements/day between two time points is reported baseline and 4 weeks after cessation of treatment (at 6 weeks)" (NCT04557215)
Timeframe: value at 6 weeks minus value at baseline
| Intervention | number of bowel movements (Mean) |
|---|---|
| Rifaximin 550 mg | -0.04 |
| Rifaximin 200 mg + Placebo | -0.50 |
| Rifaximin 200 mg Plus N-acetylcysteine (NAC) 600 mg Days | -0.24 |
Association of urgency symptom and rectal sensitivity will be evaluated by the mean change in the balloon pressure (measured in mmHg) that leads to first urge sensation to defecate, evaluated based on the visual analogue scale defined in the primary outcome measure. (NCT03462966)
Timeframe: After completing 14-day course of rifaximin.
| Intervention | Millimetre of mercury (Mean) |
|---|---|
| Therapeutic | 106 |
A 100-cubic centimeter visual analogue scale with verbal descriptors (0=no sensation, 20=first sensation, 40=first sense of urge, 60=normal urge to defecate, 80=severe urge to defecate, and 100=discomfort/pain) will be used to score evoked sensations. (NCT03462966)
Timeframe: After completing 14-day course of rifaximin.
| Intervention | volume cubic centimeter (Mean) |
|---|---|
| Therapeutic | 37.5 |
"Normalization of lactulose breath test as a potential predictor of improvement of rectal hypersensitivity will be evaluated by comparing lactulose breath test results pre- and post-treatment.~Normalization of lactulose breath test defined as rise of hydrogen <20 Parts per million within 90 minutes of lactulose ingestion.~patients with positive" (NCT03462966)
Timeframe: After completing 14-day course of rifaximin
| Intervention | Participants (Count of Participants) |
|---|---|
| Therapeutic | 2 |
2 reviews available for hydrogen and Irritable Bowel Syndrome
| Article | Year |
|---|---|
Evaluation of small intestinal bacterial overgrowth.
Topics: Bacterial Infections; Breath Tests; Gastrointestinal Microbiome; Humans; Hydrogen; Intestine, Small; | 2023 |
Mechanisms and efficacy of dietary FODMAP restriction in IBS.
Topics: Contraindications; Diet Therapy; Diet, Carbohydrate-Restricted; Disaccharides; Humans; Hydrogen; Irr | 2014 |
14 trials available for hydrogen and Irritable Bowel Syndrome
| Article | Year |
|---|---|
Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study.
Topics: Diarrhea; Gastrointestinal Microbiome; Humans; Hydrogen; Intestine, Small; Irritable Bowel Syndrome; | 2023 |
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Topics: Breath Tests; Fermentation; Humans; Hydrogen; Inulin; Irritable Bowel Syndrome; Magnetic Resonance I | 2022 |
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Topics: Breath Tests; Fermentation; Humans; Hydrogen; Inulin; Irritable Bowel Syndrome; Magnetic Resonance I | 2022 |
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Topics: Breath Tests; Fermentation; Humans; Hydrogen; Inulin; Irritable Bowel Syndrome; Magnetic Resonance I | 2022 |
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Topics: Breath Tests; Fermentation; Humans; Hydrogen; Inulin; Irritable Bowel Syndrome; Magnetic Resonance I | 2022 |
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Topics: Breath Tests; Fermentation; Humans; Hydrogen; Inulin; Irritable Bowel Syndrome; Magnetic Resonance I | 2022 |
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Topics: Breath Tests; Fermentation; Humans; Hydrogen; Inulin; Irritable Bowel Syndrome; Magnetic Resonance I | 2022 |
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Topics: Breath Tests; Fermentation; Humans; Hydrogen; Inulin; Irritable Bowel Syndrome; Magnetic Resonance I | 2022 |
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Topics: Breath Tests; Fermentation; Humans; Hydrogen; Inulin; Irritable Bowel Syndrome; Magnetic Resonance I | 2022 |
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Topics: Breath Tests; Fermentation; Humans; Hydrogen; Inulin; Irritable Bowel Syndrome; Magnetic Resonance I | 2022 |
Fructans Exacerbate Symptoms in a Subset of Children With Irritable Bowel Syndrome.
Topics: Adolescent; Breath Tests; Child; Cross-Over Studies; Diarrhea; Dietary Supplements; Double-Blind Met | 2018 |
Fasting breath H2 and gut microbiota metabolic potential are associated with the response to a fermented milk product in irritable bowel syndrome.
Topics: Adult; Breath Tests; Cultured Milk Products; Endpoint Determination; Fasting; Female; Gastrointestin | 2019 |
Association between symptoms of irritable bowel syndrome and methane and hydrogen on lactulose breath test.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Female; Flatulence; Gases; Humans; Hydrogen; | 2013 |
Effect of fructose-reduced diet in patients with irritable bowel syndrome, and its correlation to a standard fructose breath test.
Topics: Adolescent; Adult; Aged; Biomarkers; Breath Tests; Dietary Carbohydrates; Female; Fructose; Humans; | 2013 |
Breath tests in the diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome in comparison with quantitative upper gut aspirate culture.
Topics: Adolescent; Adult; Aged; Blind Loop Syndrome; Breath Tests; Diarrhea; Female; Glucose; Humans; Hydro | 2014 |
Poor predictive value of breath hydrogen response for probiotic effects in IBS.
Topics: Adult; Aged; Biomarkers; Breath Tests; Double-Blind Method; Female; Gastric Emptying; Humans; Hydrog | 2015 |
Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea.
Topics: Biomarkers; Breath Tests; China; Cross-Over Studies; Diarrhea; Double-Blind Method; Genetic Predispo | 2015 |
Lactulose Breath Test Gas Production in Childhood IBS Is Associated With Intestinal Transit and Bowel Movement Frequency.
Topics: Abdominal Pain; Adolescent; Biomarkers; Breath Tests; Child; Defecation; Depression; Female; Gastroi | 2017 |
Adding glucose to food and solutions to enhance fructose absorption is not effective in preventing fructose-induced functional gastrointestinal symptoms: randomised controlled trials in patients with fructose malabsorption.
Topics: Adolescent; Adult; Aged; Australia; Breath Tests; Cross-Over Studies; Diet; Double-Blind Method; End | 2017 |
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid; | 2017 |
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid; | 2017 |
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid; | 2017 |
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid; | 2017 |
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid; | 2017 |
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid; | 2017 |
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid; | 2017 |
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid; | 2017 |
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid; | 2017 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Aged; Breath Tests; Cross-Over Studies; Diet Records; Diet, Carbohydrate-Rest | 2010 |
Do interventions which reduce colonic bacterial fermentation improve symptoms of irritable bowel syndrome?
Topics: Adult; Anti-Infective Agents; Bacteria; Breath Tests; Calorimetry; Circadian Rhythm; Colon; Colony C | 2005 |
55 other studies available for hydrogen and Irritable Bowel Syndrome
| Article | Year |
|---|---|
Adding a liquid test meal to a standardized lactulose hydrogen breath test significantly influences abdominal symptom generation and hydrogen values.
Topics: Breath Tests; Humans; Hydrogen; Irritable Bowel Syndrome; Lactulose; Meals | 2021 |
Cost-Benefit Analysis of Hydrogen Breath Test-Directed Rifaximin for Treatment of Diarrhea-Predominant Irritable Bowel Syndrome.
Topics: Breath Tests; Cost-Benefit Analysis; Diarrhea; Humans; Hydrogen; Irritable Bowel Syndrome; Rifamycin | 2023 |
Associations between postprandial symptoms, hydrogen and methane production, and transit time in irritable bowel syndrome.
Topics: Abdominal Pain; Humans; Hydrogen; Irritable Bowel Syndrome; Lactulose; Methane; Nausea | 2023 |
Methanogen Levels Are Significantly Associated with Fecal Microbiota Composition and Alpha Diversity in Healthy Adults and Irritable Bowel Syndrome Patients.
Topics: Adult; Feces; Gastrointestinal Microbiome; Humans; Hydrogen; Irritable Bowel Syndrome; Longitudinal | 2022 |
Association of serotonin transporter promoter polymorphism (5-HTTLPR) with orocecal transit time in irritable bowel syndrome.
Topics: Case-Control Studies; Constipation; Diarrhea; Humans; Hydrogen; Irritable Bowel Syndrome; Lactulose; | 2022 |
The clinical value of breath ammonia determination in patients with irritable bowel syndrome.
Topics: Ammonia; Bacteria; Breath Tests; Humans; Hydrogen; Irritable Bowel Syndrome; Lactulose; Rifaximin | 2022 |
Shedding Light on Elevated Baseline Hydrogen and Flat-Line Patterns During Breath Testing.
Topics: Breath Tests; Diarrhea; Humans; Hydrogen; Irritable Bowel Syndrome; Lactulose; Rifaximin | 2020 |
The role of small intestinal bacterial overgrowth and false positive diagnosis of lactose intolerance in southwest Hungary-A retrospective observational study.
Topics: Adult; Bacterial Infections; Breath Tests; False Positive Reactions; Female; Gastrointestinal Tract; | 2020 |
Letter: balancing gut hydrogen as a proxy for bacteriotherapy benefits in irritable bowel syndrome.
Topics: Clostridium Infections; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Humans; Hydro | 2020 |
Hydrogen and methane breath test results are negatively associated with IBS and may reflect transit time in post-surgical patients.
Topics: Adult; Aged; Body Mass Index; Breath Tests; Digestive System Surgical Procedures; Female; Gastrointe | 2021 |
Diet and gut microbiome interactions of relevance for symptoms in irritable bowel syndrome.
Topics: Animals; Diet; Gastrointestinal Microbiome; Humans; Hydrogen; Irritable Bowel Syndrome; Microbiota | 2021 |
Better response to low FODMAP diet in disorders of gut-brain interaction patients with pronounced hydrogen response to a nutrient challenge test.
Topics: Adolescent; Adult; Aged; Brain-Gut Axis; Breath Tests; Diet, Carbohydrate-Restricted; Dyspepsia; Fem | 2021 |
Obesity Is Inversely Related to Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Non-Constipation Irritable Bowel Syndrome.
Topics: Adult; Bacteria; Body Mass Index; Breath Tests; Female; Humans; Hydrogen; Intestine, Small; Irritabl | 2017 |
Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China.
Topics: Adult; Animals; Breath Tests; China; Diarrhea; Female; Humans; Hydrogen; Irritable Bowel Syndrome; L | 2017 |
A Pilot Study of the Effect of Green Kiwifruit on Human Intestinal Fermentation Measured by Hydrogen and Methane Breath Testing.
Topics: Actinidia; Adolescent; Adult; Breath Tests; Female; Fermentation; Fruit; Humans; Hydrogen; Intestina | 2018 |
Functional Dyspepsia and Severity of Psychologic Symptoms Associate With Postprandial Symptoms in Patients With Irritable Bowel Syndrome.
Topics: Adult; Anxiety; Breath Tests; Depression; Dyspepsia; Female; Humans; Hydrogen; Irritable Bowel Syndr | 2018 |
Differentiation of functional gastrointestinal disorders from healthy volunteers by lactulose hydrogen breath test and test meal.
Topics: Adolescent; Adult; Aged; Biomarkers; Breath Tests; Diagnosis, Differential; Dyspepsia; Female; Human | 2019 |
Rifaximin for Irritable Bowel Syndrome (IBS) in Gulf War Veterans: Losing the Battle but Winning the War?
Topics: Breath Tests; Double-Blind Method; Gulf War; Humans; Hydrogen; Irritable Bowel Syndrome; Lactulose; | 2019 |
[Zaburzenia czynnościowe przewodu pokarmowego u osób z przerostem bakteryjnym jelita cienkiego].
Topics: Adult; Aged; Breath Tests; Constipation; Female; Gastrointestinal Microbiome; Humans; Hydrogen; Inte | 2019 |
Lactose malabsorption diagnosed by 50-g dose is inferior to assess clinical intolerance and to predict response to milk withdrawal than 25-g dose in an endemic area.
Topics: Adult; Animals; Breath Tests; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Genotype; | 2013 |
[Estimation of small intestinal bacterial overgrowth in patients with constipation and diarrhea irritable bowel syndrome].
Topics: Adolescent; Adult; Blind Loop Syndrome; Breath Tests; Causality; Comorbidity; Constipation; Diarrhea | 2014 |
Fructose malabsorption is not uncommon among patients with irritable bowel syndrome in India: a case-control study.
Topics: Adolescent; Adult; Aged; Biomarkers; Breath Tests; Case-Control Studies; Female; Fructose; Humans; H | 2014 |
Glucose hydrogen breath test for small intestinal bacterial overgrowth in children with abdominal pain-related functional gastrointestinal disorders.
Topics: Abdominal Pain; Adolescent; Anorexia; Bacterial Infections; Breath Tests; Child; Defecation; Female; | 2015 |
Small intestinal bacterial overgrowth as an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhea-predominant irritable bowel syndrome in Asia.
Topics: Adult; Asia; Breath Tests; Diarrhea; False Positive Reactions; Female; Gastrointestinal Transit; Hum | 2015 |
Breath Methane Excretion Is not An Accurate Marker of Colonic Methane Production in Irritable Bowel Syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Breath Tests; Case-Control Studies; Cohort S | 2015 |
Predicting a Response to Antibiotics in Patients with the Irritable Bowel Syndrome.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Breath Tests; Constipation; Diarrhea; Fema | 2016 |
Lactulose Challenge Determines Visceral Sensitivity and Severity of Symptoms in Patients With Irritable Bowel Syndrome.
Topics: Adolescent; Adult; Biota; Breath Tests; Feces; Female; Gastrointestinal Transit; Humans; Hydrogen; I | 2016 |
Breath Testing for Small Intestinal Bacterial Overgrowth: Should We Bother?
Topics: Breath Tests; Dimensional Measurement Accuracy; Gastrointestinal Agents; Gastrointestinal Microbiome | 2016 |
Does Carbohydrate Challenge Testing Predict Clinical Response in Small Intestinal Bacterial Overgrowth?
Topics: Anti-Bacterial Agents; Breath Tests; Female; Gastrointestinal Agents; Humans; Hydrogen; Intestine, S | 2016 |
Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome.
Topics: Adult; Bacteroides; Breath Tests; Case-Control Studies; Clostridiales; DNA, Bacterial; Feces; Female | 2017 |
[Irritable bowel disease with flatulence: is the breath test for carbohydrate malabsorption obligatory? Contra].
Topics: Breath Tests; Carbohydrate Metabolism, Inborn Errors; Diagnosis, Differential; False Positive Reacti | 2009 |
Proton pump inhibitor therapy does not affect hydrogen production on lactulose breath test in subjects with IBS.
Topics: Adult; Breath Tests; Female; Humans; Hydrogen; Irritable Bowel Syndrome; Lactulose; Male; Middle Age | 2010 |
Frequency of lactose malabsorption among healthy southern and northern Indian populations by genetic analysis and lactose hydrogen breath and tolerance tests.
Topics: Blood Glucose; Breath Tests; DNA; DNA Primers; Fasting; Genotype; Geography; Humans; Hydrogen; India | 2010 |
Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy.
Topics: Adult; Anti-Bacterial Agents; Bacteria; Blind Loop Syndrome; Breath Tests; Female; Gastroesophageal | 2010 |
Lactose intolerance in patients with chronic functional diarrhoea: the role of small intestinal bacterial overgrowth.
Topics: Adult; Bacterial Infections; Breath Tests; Diarrhea; Female; Humans; Hydrogen; Intestine, Small; Irr | 2010 |
Small intestinal bacterial overgrowth in irritable bowel syndrome: are there any predictors?
Topics: Adult; Aged; Aged, 80 and over; Female; Flatulence; Gases; Humans; Hydrogen; Intestine, Small; Irrit | 2010 |
Proton pump inhibitors, irritable bowel syndrome, and small intestinal bacterial overgrowth: coincidence or Newton's third law revisited?
Topics: Bacteria; Blind Loop Syndrome; Breath Tests; Humans; Hydrogen; Intestine, Small; Irritable Bowel Syn | 2010 |
Fiber, FODMAPs, flora, flatulence, and the functional bowel disorders.
Topics: Abdominal Pain; Diet, Carbohydrate-Restricted; Dietary Carbohydrates; Dietary Fiber; Fermentation; F | 2010 |
Breath testing and antibiotics for possible bacterial overgrowth in irritable bowel syndrome.
Topics: Anti-Bacterial Agents; Bacteria; Breath Tests; Humans; Hydrogen; Intestine, Small; Irritable Bowel S | 2010 |
Is small-bowel bacterial overgrowth an underdiagnosed disorder in children with gastrointestinal symptoms?
Topics: Abdominal Pain; Adolescent; Blind Loop Syndrome; Breath Tests; Child; Child, Preschool; Chronic Dise | 2011 |
Small intestinal bacterial overgrowth in patients with lower gastrointestinal symptoms and a history of previous abdominal surgery.
Topics: Adult; Aged; Anti-Infective Agents; Bacteria; Breath Tests; Diagnosis, Differential; Digestive Syste | 2011 |
The characteristics of the positivity to the lactulose breath test in patients with abdominal bloating.
Topics: Adult; Aged; Aged, 80 and over; Breath Tests; Female; Flatulence; Humans; Hydrogen; Irritable Bowel | 2011 |
Erosive esophagitis may be related to small intestinal bacterial overgrowth.
Topics: Adult; Breath Tests; Chi-Square Distribution; Endoscopy, Digestive System; Esophagitis; Female; Huma | 2012 |
Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath.
Topics: Adult; Breath Tests; Constipation; DNA, Bacterial; Feces; Female; Humans; Hydrogen; Irritable Bowel | 2012 |
Reassessment of the role of methane production between irritable bowel syndrome and functional constipation.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Bacteria; Breath Tests; Constipation; Defec | 2012 |
[Predominance of constipation in subjects with hydrogen-consuming intestinal flora].
Topics: Adult; Aged; Bacteria; Breath Tests; Case-Control Studies; Constipation; Female; Humans; Hydrogen; I | 2012 |
Effect of predominant methanogenic flora on the outcome of lactose breath test in irritable bowel syndrome patients.
Topics: Adolescent; Adult; Aged; Breath Tests; Chromatography, Gas; Female; Humans; Hydrogen; Irritable Bowe | 2003 |
IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen.
Topics: Adolescent; Adult; Aged; Breath Tests; Chromatography, High Pressure Liquid; Constipation; Diarrhea; | 2004 |
A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing.
Topics: Breath Tests; Double-Blind Method; Female; Fibromyalgia; Humans; Hydrogen; Intestine, Small; Irritab | 2004 |
Self-reported milk intolerance in irritable bowel syndrome: what should we believe?
Topics: Adult; Breath Tests; Female; Humans; Hydrogen; Irritable Bowel Syndrome; Lactose Intolerance; Malabs | 2004 |
Detection of bacterial overgrowth in IBS using the lactulose H2 breath test: comparison with 14C-D-xylose and healthy controls.
Topics: Adult; Bacteria; Breath Tests; Carbon Radioisotopes; Case-Control Studies; Female; Humans; Hydrogen; | 2005 |
Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome.
Topics: Adult; Bacterial Infections; Breath Tests; Case-Control Studies; Female; Glucose; Humans; Hydrogen; | 2005 |
Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome.
Topics: Adult; Bacterial Infections; Breath Tests; Case-Control Studies; Female; Glucose; Humans; Hydrogen; | 2005 |
Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome.
Topics: Adult; Bacterial Infections; Breath Tests; Case-Control Studies; Female; Glucose; Humans; Hydrogen; | 2005 |
Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome.
Topics: Adult; Bacterial Infections; Breath Tests; Case-Control Studies; Female; Glucose; Humans; Hydrogen; | 2005 |
[Breath hydrogen levels do not predict fiber intolerance in irritable bowel syndrome with constipation].
Topics: Aged; Breath Tests; Constipation; Dietary Fiber; Female; Fermentation; Humans; Hydrogen; Irritable B | 2007 |
Intestinal gas in plain abdominal radiographs does not correlate with symptoms after lactulose challenge.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Female; Fermentation; Flatulence; Gases; H | 2007 |
Lactulose breath test results in patients with persistent abdominal symptoms following Giardia lamblia infection.
Topics: Abdominal Pain; Adolescent; Adult; Animals; Antiprotozoal Agents; Breath Tests; Female; Giardia lamb | 2008 |