Page last updated: 2024-10-18

hydrogen and Injury, Ischemia-Reperfusion

hydrogen has been researched along with Injury, Ischemia-Reperfusion in 96 studies

Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.

Research Excerpts

ExcerptRelevanceReference
" A recent study provided evidence that hydrogen inhalation exerted antioxidant and anti-apoptotic effects and protected the brain against ischemia-reperfusion injury by selectively reducing hydroxyl radical and peroxynitrite."8.86Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. ( Cai, J; He, J; Huo, Z; Shen, M; Sun, Q; Sun, X, 2010)
"The increase in extracellular glutamate induced by spinal ischemia was significantly suppressed by 3% hydrogen gas inhalation (P < ."8.12Protective effects of hydrogen gas against spinal cord ischemia-reperfusion injury. ( Fujimoto, Y; Funao, T; Kimura, A; Mori, T; Mukai, A; Suehiro, K; Yamada, T, 2022)
"Hydrogen treatment could potentially be a future therapeutic strategy for ischemia and its derived neurodegenerative diseases by improving cognitive abilities and inducing antioxidative and antiapoptotic effects."8.02Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model. ( Choi, JI; Lee, D, 2021)
"Taken together, these results revealed the protective effect of hydrogen gas on hind limb ischemia reperfusion injury on mice by attenuating oxidative stress, impairing ER stress and apoptosis, and its ability to modulate JNK signaling pathway."8.02Protective Effect of Hydrogen Gas on Mouse Hind Limb Ischemia-Reperfusion Injury. ( Liu, J; Mei, X; Meng, J; Tong, J; Yu, P; Zhang, Y, 2021)
"To investigate the effects of hydrogen-rich saline (HRS) on intestinal epithelial tight junction (TJ) barrier in rats with intestinal ischemia-reperfusion injury (IIRI)."7.96Hydrogen-rich saline protects intestinal epithelial tight junction barrier in rats with intestinal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-induced apoptosis pathway. ( Cheng, F; Ding, G; Fan, Q; Fu, T; Geng, L; Jiang, S; Li, Z; Xu, M, 2020)
"Forty-five adult male Sprague Dawley rats (body weight 220-250 g) were randomly divided into three groups: (1) Sham operation group (SH), (2) Ischemia-reperfusion injury group (IR), and (3) Ischemia-reperfusion injury with preconditioning hydrogen group (PRH)."7.91Preconditioning with one-time hydrogen gas does not attenuate skin flap ischemia-reperfusion injury in rat models. ( Dong, X; Hao, Y; Liu, H; Wang, Y, 2019)
" Hydrogen gas provides potent anti-inflammatory and antioxidant effects against ischemia-reperfusion injury (IRI)."7.91Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death. ( Deng, L; Li, W; Liu, J; Meng, C; Zhang, J; Zhou, H, 2019)
" The hypothesis of this study is that hydrogen-rich solution could attenuateacute lung injury and improve mortality via chemerin and NLRP3 after LI/R in rats."7.91Hydrogen-Rich Saline Attenuates Acute Lung Injury Induced by Limb Ischemia/Reperfusion via Down-Regulating Chemerin and NLRP3 in Rats. ( Chen, Y; Du, J; Fan, X; Liu, KX; Wang, MH; Wang, XB; Yang, B; Zhou, J; Zou, R, 2019)
"Anti-oxidant effects of hydrogen have been reported in studies examining ischaemia-reperfusion injury (IRI)."7.85Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injury. ( Aoyama, A; Chen-Yoshikawa, TF; Date, H; Hijiya, K; Kondo, T; Miyamoto, E; Motoyama, H; Ohata, K; Saito, M; Takahashi, M; Tanaka, S, 2017)
"Lung ischemia-reperfusion injury (IRI) may be attenuated through carbon monoxide (CO)'s anti-inflammatory effect or hydrogen (H2)'s anti-oxidant effect."7.83Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats. ( Cui, X; Jiang, C; Kang, J; Liu, J; Liu, R; Ma, L; Meng, C; Niu, L; Xing, J; Zhou, H, 2016)
"Hydrogen significantly alleviated brain tissue histological damage, promoted HO-1 expression, upregulated levels of SOD, and decreased the levels of MDA in brain tissue after the ischemia reperfusion injury."7.83The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats. ( Liu, T; Wang, X; Zhang, L; Zhao, W, 2016)
"Luminal injection of hydrogen-rich solution can reduce oxidative stress and consequently ameliorate ischemic-reperfusion injury."7.81Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats. ( Cai, S; Kasahara, M; Kurokawa, R; Li, XK; Liu, C; Nakazawa, A; Sakamoto, S; Shigeta, T; Uemoto, S, 2015)
"To investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats."7.81[Role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion injury in rats]. ( Chen, X; Dai, Q; Duan, M; Gao, Y; Wu, L; Xu, J; Yu, P; Zhang, L; Zhao, L, 2015)
"The results indicate that hydrogen-rich saline could ameliorate ischemia/reperfusion injury and improve flap survival rate by inhibiting the apoptosis factor and, at the same time, promoting the expression of anti-apoptosis factor."7.81Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. ( Cheng, AX; Li, JL; Liu, YF; Liu, YQ; Ma, XM; Wang, TT; Wang, YB; Xiao, YD; Xie, F; Zhang, MZ; Zhang, X; Zhao, PX, 2015)
"Inhalation of hydrogen could attenuate renal ischemic/reperfusion injury in rats by decreasing the content of MDA."7.80[Protective effects of hydrogen on renal ischemia/reperfusion injury in rats]. ( Chen, XJ; Huang, H; Huang, W; Jiang, XQ; Zeng, K, 2014)
"These results suggest that, in our model, hydrogen enriched saline treatment is protective against liver ischemia-reperfusion injury."7.80Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. ( Irwin, MG; Liu, Y; Lloyd, DM; Ma, D; Sun, X; Tao, K; Vizcaychipi, MP; Yang, L; Yu, W, 2014)
"Molecular hydrogen has been proven effective in ameliorating cerebral ischemia/reperfusion (I/R) injury by selectively neutralizing reactive oxygen species."7.79Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. ( Bi, H; Chen, X; Kang, Z; Li, M; Liu, W; Shi, D; Shi, J; Sun, X; Wang, Q; Ye, Z; Zhai, X, 2013)
"Results provide a biochemical and histopathological basis for the action of hydrogen rich saline solution as a therapeutic agent for testicular damage induced by ischemia/reperfusion injury."7.78Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. ( Jiang, D; Li, Z; Sun, X; Wu, D; Xu, B; Zhang, Y, 2012)
"This study evaluated whether 2% hydrogen (H(2)) gas therapy protects against testicular ischemia/reperfusion injury which results in increased formation of reactive oxygen species and/or reactive nitrogen species, leading to testicular apoptosis and impaired spermatogenesis."7.78Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats. ( Cho, YJ; Han, JS; Kim, JI; Lee, DH; Lee, JW; Lee, YA; Song, CS, 2012)
"Inhalation of hydrogen gas has been proved to be an effective treatment for ischemia-reperfusion injury."7.76Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury. ( Liu, S; Sun, Q; Sun, X; Tao, H, 2010)
"Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS)."6.72Recent advances in studies of molecular hydrogen in the treatment of pancreatitis. ( Li, G; Li, Y; Suo, L; Zhang, J, 2021)
"Intestinal volvulus can cause morbidity and mortality."5.72Protective Effects of Hydrogen-Rich Saline on Experimental Intestinal Volvulus in Rats. ( Dayanır, D; Karabulut, R; Karakaya, C; Kaya, C; Oral, H; Sonmez, K; Türkyılmaz, Z, 2022)
"Hydrogen could inhibit the upregulation of autophagy in the present rodent model."5.62Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice. ( Liu, B; Liu, L; Qi, X; Qiu, T; Shen, X; Song, G; Yang, C, 2021)
"In renal transplantation, ischemia reperfusion injury impairs early graft function and can reduce long term graft survival."5.48Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model. ( Adams, T; Hosgood, SA; Moore, T; Nicholson, ML; Qurashi, M, 2018)
"Rat livers were harvested after 30-min cardiac arrest and stored for 4 h in University of Wisconsin solution."5.48Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study. ( Fujiyoshi, M; Fujiyoshi, S; Fukai, M; Hayasaka, T; Ishikawa, T; Kawamura, N; Kimura, T; Kobayashi, N; Shibata, K; Shimada, S; Shimamura, T; Taketomi, A; Umemoto, K, 2018)
"Ischemia-reperfusion injury is one of the leading causes of tissue damage and dysfunction, in particular, free tissue transfer, traumatically amputated extremity, and prolonged tourniquet application during extremity surgery."5.46Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model. ( Iuchi, K; Kamimura, N; Nishimaki, K; Ogawa, R; Ohta, S; Watanabe, M; Yokota, T, 2017)
"Hydrogen is a kind of noble gas with the character to selectively neutralize reactive oxygen species."5.43Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats - A possible new hydrogen resource for clinical use. ( Cao, L; Chen, X; Cui, J; Gu, Z; Hou, J; Ji, F; Li, X; Shi, D; Su, J; Sun, X; Wang, L; Weng, W; Zhai, X; Zhang, J; Zhang, R; Zhi, X, 2016)
"Hydrogen-rich saline treatment significantly improved the amount of surviving cells (P < 0."5.40Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats. ( Chen, H; Cui, Y; Duan, M; Ji, M; Jia, M; Yang, J; Zhang, H, 2014)
"Spinal cord ischemia was induced by infrarenal aortic occlusion for 20min in male New Zealand white rabbits."5.39Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. ( Chen, H; Gong, G; Huang, Y; Wang, X; Xie, K; Xue, W; Zeng, Y; Zhou, L, 2013)
"Hydrogen gas has been reported to alleviate cerebral I/R injury by acting as a free radical scavenger."5.39Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. ( Ma, XM; Qin, SR; Sun, XJ; Wang, ML; Wang, YB; Zhao, L; Zhong, RG, 2013)
"Global cerebral ischemia and reperfusion (I/R) often result in high mortality."5.38Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia. ( Fujita, M; Kobayashi, H; Nagatani, K; Nawashiro, H; Otani, N; Tachibana, S; Takeuchi, S; Uozumi, Y; Wada, K, 2012)
"Spinal cord ischemia was induced by infrarenal aortic occlusion for 20 min in male New Zealand white rabbits."5.37Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. ( Dong, H; Gong, G; Huang, Y; Li, J; Wang, G; Xie, K; Xiong, L; Xu, N; Yu, Y, 2011)
"Hydrogen gas has potent antioxidant and antiapoptotic properties and has been recently used in number of experimental and clinical studies."5.36Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. ( Billiar, TR; Huang, CS; Kawamura, T; Lee, S; Nakao, A; Okumura, M; Shigemura, N; Tochigi, N; Toyoda, Y, 2010)
"Hydrogen gas was reported to reduce reactive oxygen species and alleviate cerebral, myocardial and hepatic ischemia/reperfusion (I/R) injuries."5.35Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. ( Cai, J; Li, Y; Liu, W; Mao, Y; Sun, P; Sun, X; Yuan, H; Zhang, JH; Zheng, X, 2009)
" A recent study provided evidence that hydrogen inhalation exerted antioxidant and anti-apoptotic effects and protected the brain against ischemia-reperfusion injury by selectively reducing hydroxyl radical and peroxynitrite."4.86Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. ( Cai, J; He, J; Huo, Z; Shen, M; Sun, Q; Sun, X, 2010)
"Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Lung inflation using hydrogen during CIP may improve donor lung quality by mitigating mitochondrial structural anomalies, enhancing mitochondrial function, and alleviating oxidative stress, inflammation, and apoptosis, which may be achieved through activation of the Nrf2/HO-1 pathway."4.31Inflation using hydrogen improves donor lung quality by regulating mitochondrial function during cold ischemia phase. ( Duan, L; Li, Z; Quan, L; Zhang, G; Zhang, M; Zheng, B; Zhou, H, 2023)
"The increase in extracellular glutamate induced by spinal ischemia was significantly suppressed by 3% hydrogen gas inhalation (P < ."4.12Protective effects of hydrogen gas against spinal cord ischemia-reperfusion injury. ( Fujimoto, Y; Funao, T; Kimura, A; Mori, T; Mukai, A; Suehiro, K; Yamada, T, 2022)
"Taken together, these results revealed the protective effect of hydrogen gas on hind limb ischemia reperfusion injury on mice by attenuating oxidative stress, impairing ER stress and apoptosis, and its ability to modulate JNK signaling pathway."4.02Protective Effect of Hydrogen Gas on Mouse Hind Limb Ischemia-Reperfusion Injury. ( Liu, J; Mei, X; Meng, J; Tong, J; Yu, P; Zhang, Y, 2021)
"Hydrogen treatment could potentially be a future therapeutic strategy for ischemia and its derived neurodegenerative diseases by improving cognitive abilities and inducing antioxidative and antiapoptotic effects."4.02Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model. ( Choi, JI; Lee, D, 2021)
"To investigate the effects of hydrogen-rich saline (HRS) on intestinal epithelial tight junction (TJ) barrier in rats with intestinal ischemia-reperfusion injury (IIRI)."3.96Hydrogen-rich saline protects intestinal epithelial tight junction barrier in rats with intestinal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-induced apoptosis pathway. ( Cheng, F; Ding, G; Fan, Q; Fu, T; Geng, L; Jiang, S; Li, Z; Xu, M, 2020)
"Molecular hydrogen can reduce the oxidative stress of ischemia-reperfusion injury in various organs for transplantation and potentially improve survival rates in recipients."3.96Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation. ( Chen-Yoshikawa, TF; Date, H; Hirano, SI; Kayawake, H; Kurokawa, R; Saito, M; Takahashi, M; Yokoyama, Y, 2020)
"Forty-five adult male Sprague Dawley rats (body weight 220-250 g) were randomly divided into three groups: (1) Sham operation group (SH), (2) Ischemia-reperfusion injury group (IR), and (3) Ischemia-reperfusion injury with preconditioning hydrogen group (PRH)."3.91Preconditioning with one-time hydrogen gas does not attenuate skin flap ischemia-reperfusion injury in rat models. ( Dong, X; Hao, Y; Liu, H; Wang, Y, 2019)
" Hydrogen gas provides potent anti-inflammatory and antioxidant effects against ischemia-reperfusion injury (IRI)."3.91Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death. ( Deng, L; Li, W; Liu, J; Meng, C; Zhang, J; Zhou, H, 2019)
" The hypothesis of this study is that hydrogen-rich solution could attenuateacute lung injury and improve mortality via chemerin and NLRP3 after LI/R in rats."3.91Hydrogen-Rich Saline Attenuates Acute Lung Injury Induced by Limb Ischemia/Reperfusion via Down-Regulating Chemerin and NLRP3 in Rats. ( Chen, Y; Du, J; Fan, X; Liu, KX; Wang, MH; Wang, XB; Yang, B; Zhou, J; Zou, R, 2019)
"The present study aimed to investigate the effects of hydrogen rich saline solution (HRSS) in a rat model of ovarian ischemia-reperfusion injury."3.85Protective effect of hydrogen rich saline solution on experimental ovarian ischemia reperfusion model in rats. ( Basaklar, AC; Gokalp, N; Gulbahar, O; Karabulut, R; Poyraz, A; Sonmez, K; Turkyilmaz, Z, 2017)
"Anti-oxidant effects of hydrogen have been reported in studies examining ischaemia-reperfusion injury (IRI)."3.85Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injury. ( Aoyama, A; Chen-Yoshikawa, TF; Date, H; Hijiya, K; Kondo, T; Miyamoto, E; Motoyama, H; Ohata, K; Saito, M; Takahashi, M; Tanaka, S, 2017)
"Hydrogen significantly alleviated brain tissue histological damage, promoted HO-1 expression, upregulated levels of SOD, and decreased the levels of MDA in brain tissue after the ischemia reperfusion injury."3.83The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats. ( Liu, T; Wang, X; Zhang, L; Zhao, W, 2016)
"Lung ischemia-reperfusion injury (IRI) may be attenuated through carbon monoxide (CO)'s anti-inflammatory effect or hydrogen (H2)'s anti-oxidant effect."3.83Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats. ( Cui, X; Jiang, C; Kang, J; Liu, J; Liu, R; Ma, L; Meng, C; Niu, L; Xing, J; Zhou, H, 2016)
"Luminal injection of hydrogen-rich solution can reduce oxidative stress and consequently ameliorate ischemic-reperfusion injury."3.81Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats. ( Cai, S; Kasahara, M; Kurokawa, R; Li, XK; Liu, C; Nakazawa, A; Sakamoto, S; Shigeta, T; Uemoto, S, 2015)
"The results indicate that hydrogen-rich saline could ameliorate ischemia/reperfusion injury and improve flap survival rate by inhibiting the apoptosis factor and, at the same time, promoting the expression of anti-apoptosis factor."3.81Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. ( Cheng, AX; Li, JL; Liu, YF; Liu, YQ; Ma, XM; Wang, TT; Wang, YB; Xiao, YD; Xie, F; Zhang, MZ; Zhang, X; Zhao, PX, 2015)
"Hydrogen has antioxidant and anti-inflammatory effects on lung ischemia-reperfusion injury when it is inhaled by donor or/and recipient."3.81Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. ( Fang, X; Li, W; Liu, J; Liu, R; Meng, C; Xing, J; Yang, W; Zhou, H, 2015)
"To investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats."3.81[Role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion injury in rats]. ( Chen, X; Dai, Q; Duan, M; Gao, Y; Wu, L; Xu, J; Yu, P; Zhang, L; Zhao, L, 2015)
"Inhalation of hydrogen could attenuate renal ischemic/reperfusion injury in rats by decreasing the content of MDA."3.80[Protective effects of hydrogen on renal ischemia/reperfusion injury in rats]. ( Chen, XJ; Huang, H; Huang, W; Jiang, XQ; Zeng, K, 2014)
"These results suggest that, in our model, hydrogen enriched saline treatment is protective against liver ischemia-reperfusion injury."3.80Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. ( Irwin, MG; Liu, Y; Lloyd, DM; Ma, D; Sun, X; Tao, K; Vizcaychipi, MP; Yang, L; Yu, W, 2014)
"Molecular hydrogen has been proven effective in ameliorating cerebral ischemia/reperfusion (I/R) injury by selectively neutralizing reactive oxygen species."3.79Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. ( Bi, H; Chen, X; Kang, Z; Li, M; Liu, W; Shi, D; Shi, J; Sun, X; Wang, Q; Ye, Z; Zhai, X, 2013)
"This study evaluated whether 2% hydrogen (H(2)) gas therapy protects against testicular ischemia/reperfusion injury which results in increased formation of reactive oxygen species and/or reactive nitrogen species, leading to testicular apoptosis and impaired spermatogenesis."3.78Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats. ( Cho, YJ; Han, JS; Kim, JI; Lee, DH; Lee, JW; Lee, YA; Song, CS, 2012)
"Results provide a biochemical and histopathological basis for the action of hydrogen rich saline solution as a therapeutic agent for testicular damage induced by ischemia/reperfusion injury."3.78Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. ( Jiang, D; Li, Z; Sun, X; Wu, D; Xu, B; Zhang, Y, 2012)
"Inhalation of hydrogen gas has been proved to be an effective treatment for ischemia-reperfusion injury."3.76Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury. ( Liu, S; Sun, Q; Sun, X; Tao, H, 2010)
"Ischemia reperfusion injury (IRI) in organ transplantation has always been an important hotspot in organ protection."2.72Hydrogen: Potential Applications in Solid Organ Transplantation. ( Huang, X; Lan, Y; Lei, Y; Li, J; Liu, R; Lu, S; Luo, X; Yang, F; Zeng, F, 2021)
"Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS)."2.72Recent advances in studies of molecular hydrogen in the treatment of pancreatitis. ( Li, G; Li, Y; Suo, L; Zhang, J, 2021)
"Hydrogen gas has been reported to have medical efficacy since the 1880s."2.61Medical Application of Hydrogen in Hematological Diseases. ( Cen, J; Pasca, S; Qian, L; Tomuleasa, C; Wu, Z, 2019)
"1."2.47Hydrogen resuscitation, a new cytoprotective approach. ( Sun, XJ; Xia, ZF; Zheng, XF, 2011)
"Intestinal volvulus can cause morbidity and mortality."1.72Protective Effects of Hydrogen-Rich Saline on Experimental Intestinal Volvulus in Rats. ( Dayanır, D; Karabulut, R; Karakaya, C; Kaya, C; Oral, H; Sonmez, K; Türkyılmaz, Z, 2022)
"Hydrogen could inhibit the upregulation of autophagy in the present rodent model."1.62Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice. ( Liu, B; Liu, L; Qi, X; Qiu, T; Shen, X; Song, G; Yang, C, 2021)
"When hydrogen gas was infused into a bag containing cold ETK organ preservation solution at a pressure of 0."1.51Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs. ( Kobayashi, E; Sano, M, 2019)
"Rat livers were harvested after 30-min cardiac arrest and stored for 4 h in University of Wisconsin solution."1.48Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study. ( Fujiyoshi, M; Fujiyoshi, S; Fukai, M; Hayasaka, T; Ishikawa, T; Kawamura, N; Kimura, T; Kobayashi, N; Shibata, K; Shimada, S; Shimamura, T; Taketomi, A; Umemoto, K, 2018)
"In renal transplantation, ischemia reperfusion injury impairs early graft function and can reduce long term graft survival."1.48Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model. ( Adams, T; Hosgood, SA; Moore, T; Nicholson, ML; Qurashi, M, 2018)
"Hepatic ischemia reperfusion injury (HIRI) occurs commonly in liver surgery and liver transplantation."1.48Effect of hydrogen-rich saline on apoptosis induced by hepatic ischemia reperfusion upon laparoscopic hepatectomy in miniature pigs. ( Bai, G; Ge, Y; Jiao, Z; Kong, X; Li, H; Meng, W; Wang, H; Zhang, Q, 2018)
"Ischemia-reperfusion injury is one of the leading causes of tissue damage and dysfunction, in particular, free tissue transfer, traumatically amputated extremity, and prolonged tourniquet application during extremity surgery."1.46Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model. ( Iuchi, K; Kamimura, N; Nishimaki, K; Ogawa, R; Ohta, S; Watanabe, M; Yokota, T, 2017)
"Hydrogen is a kind of noble gas with the character to selectively neutralize reactive oxygen species."1.43Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats - A possible new hydrogen resource for clinical use. ( Cao, L; Chen, X; Cui, J; Gu, Z; Hou, J; Ji, F; Li, X; Shi, D; Su, J; Sun, X; Wang, L; Weng, W; Zhai, X; Zhang, J; Zhang, R; Zhi, X, 2016)
"Hydrogen-rich saline treatment significantly improved the amount of surviving cells (P < 0."1.40Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats. ( Chen, H; Cui, Y; Duan, M; Ji, M; Jia, M; Yang, J; Zhang, H, 2014)
"Hydrogen gas has been reported to alleviate cerebral I/R injury by acting as a free radical scavenger."1.39Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. ( Ma, XM; Qin, SR; Sun, XJ; Wang, ML; Wang, YB; Zhao, L; Zhong, RG, 2013)
"Spinal cord ischemia was induced by infrarenal aortic occlusion for 20min in male New Zealand white rabbits."1.39Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. ( Chen, H; Gong, G; Huang, Y; Wang, X; Xie, K; Xue, W; Zeng, Y; Zhou, L, 2013)
"The process of brain death induces acute lung injury in donors and aggravates ischemia-reperfusion injury (IRI) in grafts."1.39Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. ( Cui, X; Ding, W; Fu, Z; Li, W; Liu, J; Pan, P; Wei, Y; Yang, W; Zhou, H, 2013)
"Global cerebral ischemia and reperfusion (I/R) often result in high mortality."1.38Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia. ( Fujita, M; Kobayashi, H; Nagatani, K; Nawashiro, H; Otani, N; Tachibana, S; Takeuchi, S; Uozumi, Y; Wada, K, 2012)
"Hydrogen treatment induced several lung surfactant-related genes, ATP synthase genes and stress-response genes."1.38Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. ( Bermudez, CA; Billiar, TR; Isse, K; Kawamura, T; Lyons-Weiler, J; Nakao, A; Noda, K; Shigemura, N; Stolz, DB; Tanaka, Y; Toyoda, Y, 2012)
"Hydrogen has been considered as a novel antioxidant that prevents injuries resulted from ischemia-reperfusion (I/R) injury in various tissues."1.37The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. ( Chen, H; Hu, PF; Li, Y; Liu, WW; Ruan, CP; Su, N; Sun, XJ; Sun, YP; Wang, Q; Xiang, HG; Yan, RL, 2011)
"Spinal cord ischemia was induced by infrarenal aortic occlusion for 20 min in male New Zealand white rabbits."1.37Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. ( Dong, H; Gong, G; Huang, Y; Li, J; Wang, G; Xie, K; Xiong, L; Xu, N; Yu, Y, 2011)
"Malondialdehyde (MDA) was measured to quantify the oxidative stress."1.37The effect of hydrogen-rich saline on the brain of rats with transient ischemia. ( Duan, M; Hui, K; Ji, Q; Li, W; Sun, X; Zhang, L, 2011)
"Hydrogen gas has potent antioxidant and antiapoptotic properties and has been recently used in number of experimental and clinical studies."1.36Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. ( Billiar, TR; Huang, CS; Kawamura, T; Lee, S; Nakao, A; Okumura, M; Shigemura, N; Tochigi, N; Toyoda, Y, 2010)
"Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappaB activation and the pro-inflammatory cytokine interleukin IL-1beta and TNF-alpha in the lung tissues compared with those in saline-treated rat."1.35Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. ( Cai, JM; Deng, XM; Jiang, L; Mao, YF; Sun, XJ; You, XM; Zhang, JH; Zheng, XF, 2009)
"Hydrogen gas was reported to reduce reactive oxygen species and alleviate cerebral, myocardial and hepatic ischemia/reperfusion (I/R) injuries."1.35Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. ( Cai, J; Li, Y; Liu, W; Mao, Y; Sun, P; Sun, X; Yuan, H; Zhang, JH; Zheng, X, 2009)
"Hydrogen treatment resulted in significantly improved gastrointestinal transit, as well as jejunal smooth muscle contractility in response to bethanechol."1.35Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. ( Bauer, AJ; Billiar, TR; Buchholz, BM; Kaczorowski, DJ; McCurry, KR; Nakao, A; Sugimoto, R; Wang, Y; Yang, R, 2008)
" The aim of this study was the validation of thermodiffusion in a new modification allowing long-term use in the clinical setting."1.30Thermodiffusion for continuous quantification of hepatic microcirculation--validation and potential in liver transplantation. ( Bleyl, J; Bowman, HF; Bredt, M; Herfarth, C; Hofmann, WJ; Klar, E; Kraus, T; Kummer, R; Newman, WH, 1999)

Research

Studies (96)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (3.13)18.2507
2000's8 (8.33)29.6817
2010's69 (71.88)24.3611
2020's16 (16.67)2.80

Authors

AuthorsStudies
Lee, D1
Choi, JI1
Yang, F3
Lei, Y1
Liu, R3
Luo, X2
Li, J9
Zeng, F1
Lu, S1
Huang, X3
Lan, Y1
Oral, H1
Türkyılmaz, Z2
Karabulut, R2
Kaya, C1
Dayanır, D1
Karakaya, C1
Sonmez, K2
Otani, N2
Tomita, K1
Kobayashi, Y1
Kuroda, K1
Koyama, Y1
Kobayashi, H2
Kubo, T1
Fukai, M3
Sakamoto, S4
Bochimoto, H2
Zin, NKM1
Shibata, K3
Ishikawa, T3
Shimada, S3
Kawamura, N3
Fujiyoshi, M3
Fujiyoshi, S3
Nakamura, K2
Shimamura, T3
Taketomi, A3
Duan, L1
Quan, L1
Zheng, B1
Li, Z6
Zhang, G2
Zhang, M2
Zhou, H6
Zhang, Q7
Piao, C1
Xu, J4
Jiao, Z2
Ge, Y3
Liu, X4
Ma, Y2
Wang, H6
Kobayashi, E1
Sano, M2
Saito, M2
Chen-Yoshikawa, TF2
Takahashi, M2
Kayawake, H1
Yokoyama, Y1
Kurokawa, R2
Hirano, SI1
Date, H2
Qian, L1
Wu, Z1
Cen, J1
Pasca, S1
Tomuleasa, C1
Jiang, S1
Fan, Q1
Xu, M1
Cheng, F1
Ding, G1
Geng, L1
Fu, T1
Halim, AA1
Alsayed, B1
Embarak, S1
Yaseen, T1
Dabbous, S1
Fontaine, O1
Dueluzeau, R1
Raibaud, P1
Chabanet, C1
Popoff, MR1
Badoual, J1
Gabilan, JC1
Andremont, A1
Gómez, L1
Andrés, S1
Sánchez, J1
Alonso, JM1
Rey, J1
López, F1
Jiménez, A1
Yan, Z1
Zhou, L2
Zhao, Y3
Wang, J6
Huang, L2
Hu, K1
Liu, H6
Guo, Z1
Song, Y1
Huang, H5
Yang, R2
Owen, TW1
Al-Kaysi, RO1
Bardeen, CJ1
Cheng, Q1
Wu, S1
Cheng, T1
Zhou, X1
Wang, B4
Wu, X3
Yao, Y3
Ochiai, T1
Ishiguro, H2
Nakano, R2
Kubota, Y2
Hara, M1
Sunada, K1
Hashimoto, K1
Kajioka, J1
Fujishima, A1
Jiao, J3
Gai, QY3
Wang, W3
Zang, YP2
Niu, LL2
Fu, YJ3
Wang, X6
Yao, LP1
Qin, QP1
Wang, ZY1
Liu, J10
Aleksic Sabo, V1
Knezevic, P1
Borges-Argáez, R1
Chan-Balan, R1
Cetina-Montejo, L1
Ayora-Talavera, G1
Sansores-Peraza, P1
Gómez-Carballo, J1
Cáceres-Farfán, M1
Jang, J1
Akin, D1
Bashir, R1
Yu, Z1
Zhu, J2
Jiang, H1
He, C2
Xiao, Z1
Sun, Q6
Han, D1
Lei, H1
Zhao, K2
Zhu, L1
Li, X6
Fu, H2
Wilson, BK1
Step, DL1
Maxwell, CL1
Gifford, CA1
Richards, CJ1
Krehbiel, CR1
Warner, JM1
Doerr, AJ1
Erickson, GE1
Guretzky, JA1
Rasby, RJ1
Watson, AK1
Klopfenstein, TJ1
Sun, Y4
Liu, Z3
Pham, TD1
Lee, BK1
Yang, FC1
Wu, KH1
Lin, WP1
Hu, MK1
Lin, L3
Shao, J1
Sun, M1
Xu, G1
Zhang, X8
Xu, N2
Wang, R3
Liu, S2
He, H1
Dong, X3
Yang, M2
Yang, Q1
Duan, S1
Yu, Y4
Han, J2
Zhang, C3
Chen, L3
Yang, X1
Li, W7
Wang, T2
Campbell, DA1
Gao, K1
Zager, RA1
Johnson, ACM1
Guillem, A1
Keyser, J1
Singh, B1
Steubl, D1
Schneider, MP1
Meiselbach, H1
Nadal, J1
Schmid, MC1
Saritas, T1
Krane, V1
Sommerer, C1
Baid-Agrawal, S1
Voelkl, J1
Kotsis, F1
Köttgen, A1
Eckardt, KU1
Scherberich, JE1
Li, H7
Yao, L2
Sun, L3
Zhu, Z1
Naren, N1
Zhang, XX2
Gentile, GL1
Rupert, AS1
Carrasco, LI1
Garcia, EM1
Kumar, NG1
Walsh, SW1
Jefferson, KK1
Guest, RL1
Samé Guerra, D1
Wissler, M1
Grimm, J1
Silhavy, TJ1
Lee, JH2
Yoo, JS1
Kim, Y1
Kim, JS2
Lee, EJ1
Roe, JH1
Delorme, M1
Bouchard, PA1
Simon, M1
Simard, S1
Lellouche, F1
D'Urzo, KA1
Mok, F1
D'Urzo, AD1
Koneru, B1
Lopez, G1
Farooqi, A1
Conkrite, KL1
Nguyen, TH1
Macha, SJ1
Modi, A1
Rokita, JL1
Urias, E1
Hindle, A1
Davidson, H1
Mccoy, K1
Nance, J1
Yazdani, V1
Irwin, MS1
Yang, S1
Wheeler, DA1
Maris, JM1
Diskin, SJ1
Reynolds, CP1
Abhilash, L1
Kalliyil, A1
Sheeba, V1
Hartley, AM2
Meunier, B2
Pinotsis, N1
Maréchal, A2
Xu, JY1
Genko, N1
Haraux, F1
Rich, PR1
Kamalanathan, M1
Doyle, SM1
Xu, C1
Achberger, AM1
Wade, TL1
Schwehr, K1
Santschi, PH1
Sylvan, JB1
Quigg, A1
Leong, W1
Xu, W2
Gao, S1
Zhai, X3
Wang, C2
Gilson, E1
Ye, J1
Lu, Y1
Yan, R1
Zhang, Y8
Hu, Z1
You, Q1
Cai, Q1
Yang, D2
Gu, S1
Dai, H1
Zhao, X1
Gui, C1
Gui, J1
Wu, PK1
Hong, SK1
Starenki, D1
Oshima, K1
Shao, H1
Gestwicki, JE1
Tsai, S1
Park, JI1
Wang, Y9
Zhao, R1
Gu, Z2
Dong, C2
Guo, G1
Li, L4
Barrett, HE1
Meester, EJ1
van Gaalen, K1
van der Heiden, K1
Krenning, BJ1
Beekman, FJ1
de Blois, E1
de Swart, J1
Verhagen, HJ1
Maina, T1
Nock, BA1
Norenberg, JP1
de Jong, M1
Gijsen, FJH1
Bernsen, MR1
Martínez-Milla, J1
Galán-Arriola, C1
Carnero, M1
Cobiella, J1
Pérez-Camargo, D1
Bautista-Hernández, V1
Rigol, M1
Solanes, N1
Villena-Gutierrez, R1
Lobo, M1
Mateo, J1
Vilchez-Tschischke, JP1
Salinas, B1
Cussó, L1
López, GJ1
Fuster, V1
Desco, M1
Sanchez-González, J1
Ibanez, B1
van den Berg, P1
Schweitzer, DH1
van Haard, PMM1
Geusens, PP1
van den Bergh, JP1
Zhu, X1
Xu, H2
Yang, G2
Lin, Z1
Salem, HF1
Nafady, MM1
Kharshoum, RM1
Abd El-Ghafar, OA1
Farouk, HO1
Domiciano, D1
Nery, FC1
de Carvalho, PA1
Prudente, DO1
de Souza, LB1
Chalfun-Júnior, A1
Paiva, R1
Marchiori, PER1
Lu, M2
An, Z1
Jiang, J2
Du, S1
Cui, J3
Wu, W1
Liu, Y9
Song, J1
Lian, Q1
Uddin Ahmad, Z1
Gang, DD1
Konggidinata, MI1
Gallo, AA1
Zappi, ME1
Yang, TWW1
Johari, Y1
Burton, PR1
Earnest, A1
Shaw, K1
Hare, JL1
Brown, WA1
Kim, GA1
Han, S1
Choi, GH1
Choi, J1
Lim, YS1
Gallo, A1
Cancelli, C1
Ceron, E1
Covino, M1
Capoluongo, E1
Pocino, K1
Ianiro, G1
Cammarota, G1
Gasbarrini, A1
Montalto, M1
Somasundar, Y1
Lu, IC1
Mills, MR1
Qian, LY1
Olivares, X1
Ryabov, AD1
Collins, TJ1
Zhao, L3
Doddipatla, S1
Thomas, AM1
Nikolayev, AA1
Galimova, GR1
Azyazov, VN1
Mebel, AM1
Kaiser, RI1
Guo, S1
Yang, P1
Yu, X2
Wu, Y2
Zhang, H2
Yu, B2
Han, B1
George, MW1
Moor, MB1
Bonny, O1
Langenberg, E1
Paik, H1
Smith, EH1
Nair, HP1
Hanke, I1
Ganschow, S1
Catalan, G1
Domingo, N1
Schlom, DG1
Assefa, MK1
Wu, G2
Hayton, TW1
Becker, B1
Enikeev, D1
Netsch, C1
Gross, AJ1
Laukhtina, E1
Glybochko, P1
Rapoport, L1
Herrmann, TRW1
Taratkin, M1
Dai, W1
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Carreno, J1
Kloner, RA1
Pickersgill, NA1
Vetter, JM1
Kim, EH1
Cope, SJ1
Du, K1
Venkatesh, R1
Giardina, JD1
Saad, NES1
Bhayani, SB1
Figenshau, RS1
Eriksson, J1
Landfeldt, E1
Ireland, S1
Jackson, C1
Wyatt, E1
Gaudig, M1
Stancill, JS1
Happ, JT1
Broniowska, KA1
Hogg, N1
Corbett, JA1
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Bi, YL1
Fan, Y2
Sun, YB1
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Qiu, SW1
Guo, SW1
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Sun, J2
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Pan, Q1
Li, D3
Zheng, S2
Ma, L2
Wang, L4
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Lennerz, JK1
Sadow, PM1
Frazier, RP1
Govinda Raju, S1
Henry, D1
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Marti, CN1
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Bae, SJ1
Ni, L1
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Lee, R1
Fleischer, AS1
Wemhoff, AP1
Ford, CR1
Kleppinger, EL1
Helms, K1
Bush, AA1
Luna-Abanto, J1
García Ruiz, L1
Laura Martinez, J1
Álvarez Larraondo, M1
Villoslada Terrones, V1
Dukic, L1
Maric, N1
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Kalthur, SG1
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El Massoudi, S1
El Ghadraoui, L1
Lazraq, A1
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Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hydrogen-Rich Celsior Solution Improve the Quality of Aging DBD Grafts in Liver/Kidney Transplantation: Prospective, Randomized Clinical Trial[NCT02613195]Phase 320 participants (Anticipated)Interventional2016-01-31Not yet recruiting
The Effect of Perioperative Hydrogen Inhalation on Post-operative Pain and Inflammation Cytokines[NCT05476575]32 participants (Anticipated)Interventional2021-10-28Recruiting
Efficacy and Safety of Hydrogen Inhalation on Bronchiectasis (HYBRID): A Randomized, Multi-center, Double-blind, Parallel-group Study[NCT02765295]120 participants (Anticipated)Interventional2016-06-01Recruiting
Evaluation of the Daily Intake of 0.5 L of Water Saturated With Molecular Hydrogen for 21 Days in COVID-19 Patients Treated in Ambulatory Care. Double-blind, Randomized, Comparative Study[NCT04716985]700 participants (Actual)Interventional2021-01-22Active, not recruiting
Adjuvant Therapy for Severe COPD Patients in the Stable Phase by an Oxyhydrogen Generator With Nebulizer: A Multi-centric, Randomized, Parallel-control and Double-blinded Clinic Study[NCT02850185]170 participants (Anticipated)Interventional2016-07-15Recruiting
Adjuvant Therapy for Severe Asthma by an Oxyhydrogen Generator With Nebulizer: A Multi-centric, Randomized, Parallel-control and Double-blinded Clinic Study on Effectiveness and Safety[NCT02883582]150 participants (Anticipated)Interventional2016-08-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for hydrogen and Injury, Ischemia-Reperfusion

ArticleYear
Hydrogen: Potential Applications in Solid Organ Transplantation.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Humans; Hydrogen; Organ Transplantation; Reperfusion Injury

2021
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Medical Application of Hydrogen in Hematological Diseases.
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Disease Models, Animal; Humans; Hydrogen

2019
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.
    Life sciences, 2021, Jan-01, Volume: 264

    Topics: Animals; Antioxidants; Apoptosis; Autophagy; Cell Death; Endoplasmic Reticulum Stress; Humans; Hydro

2021
Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.
    Current pharmaceutical design, 2021, Volume: 27, Issue:5

    Topics: Anti-Inflammatory Agents; COVID-19; Humans; Hydrogen; Reperfusion Injury; SARS-CoV-2

2021
[Initiation, development and potential of hydrogen medicine: Toward therapeutic and preventive applications of molecular hydrogen against a variety of diseases].
    Seikagaku. The Journal of Japanese Biochemical Society, 2015, Volume: 87, Issue:1

    Topics: Animals; Antioxidants; Gene Expression; Humans; Hydrogen; Neurodegenerative Diseases; Oxidative Stre

2015
Hydrogen, a potential safeguard for graft-versus-host disease and graft ischemia-reperfusion injury?
    Clinics (Sao Paulo, Brazil), 2016, Volume: 71, Issue:9

    Topics: Animals; Antioxidants; Cytokines; Graft vs Host Disease; Hydrogen; Organ Transplantation; Oxidative

2016
Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.
    Medical hypotheses, 2010, Volume: 75, Issue:2

    Topics: Antioxidants; Brain; Carbon Monoxide Poisoning; Cell Death; Free Radical Scavengers; Free Radicals;

2010
Hydrogen resuscitation, a new cytoprotective approach.
    Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:3

    Topics: Animals; Antioxidants; Apoptosis; Cytoprotection; Humans; Hydrogen; Reperfusion Injury

2011
[Hydrogen and oxidative stress injury--from an inert gas to a medical gas].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2011, Apr-18, Volume: 43, Issue:2

    Topics: Antioxidants; Humans; Hydrogen; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury

2011

Trials

2 trials available for hydrogen and Injury, Ischemia-Reperfusion

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016

Other Studies

85 other studies available for hydrogen and Injury, Ischemia-Reperfusion

ArticleYear
Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model.
    BioMed research international, 2021, Volume: 2021

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain Ischemia; Cognition; Deuterium Oxi

2021
Protective Effects of Hydrogen-Rich Saline on Experimental Intestinal Volvulus in Rats.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2022, Volume: 35, Issue:7

    Topics: Animals; Antioxidants; Hydrogen; Intestinal Volvulus; Oxidative Stress; Rats; Reperfusion Injury; Sa

2022
Hydrogen-generating Si-based agent protects against skin flap ischemia-reperfusion injury in rats.
    Scientific reports, 2022, 04-13, Volume: 12, Issue:1

    Topics: Animals; Disease Models, Animal; Hydrogen; Inflammation; Rats; Rats, Sprague-Dawley; Reperfusion Inj

2022
Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to Restore Organ Function.
    Transplantation proceedings, 2023, Volume: 55, Issue:4

    Topics: Animals; Hydrogen; Liver; Liver Transplantation; Organ Preservation; Perfusion; Rats; Reperfusion In

2023
Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers.
    Transplantation proceedings, 2023, Volume: 55, Issue:4

    Topics: Animals; Deuterium Oxide; Glutathione; Hydrogen; Insulin; Liver; Organ Preservation; Organ Preservat

2023
Inflation using hydrogen improves donor lung quality by regulating mitochondrial function during cold ischemia phase.
    BMC pulmonary medicine, 2023, Jun-17, Volume: 23, Issue:1

    Topics: Apoptosis; Cold Ischemia; Heme Oxygenase-1; Humans; Hydrogen; Inflammation; Lung; NF-E2-Related Fact

2023
Comparative study on protective effect of hydrogen rich saline and adipose-derived stem cells on hepatic ischemia-reperfusion and hepatectomy injury in swine.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 120

    Topics: Adipocytes; Animals; Apoptosis; Hepatectomy; Hydrogen; Inflammation; Liver; Liver Function Tests; Li

2019
Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs.
    PloS one, 2019, Volume: 14, Issue:10

    Topics: Alloys; Animals; Disease Models, Animal; Gases; Graft Survival; Humans; Hydrogen; Ischemia; Kidney;

2019
Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation.
    The Journal of thoracic and cardiovascular surgery, 2020, Volume: 159, Issue:5

    Topics: Animals; Cold Ischemia; Cytokines; Disease Models, Animal; Hydrogen; Lung; Lung Transplantation; Mal

2020
Hydrogen-rich saline protects intestinal epithelial tight junction barrier in rats with intestinal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-induced apoptosis pathway.
    Journal of pediatric surgery, 2020, Volume: 55, Issue:12

    Topics: Animals; Apoptosis; Endoplasmic Reticulum Stress; Hydrogen; Male; Rats; Rats, Sprague-Dawley; Reperf

2020
Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats.
    Life sciences, 2021, May-01, Volume: 272

    Topics: Administration, Inhalation; Animals; Cell Survival; Hydrogen; Inflammasomes; Male; Myocardial Infarc

2021
Protective Effect of Hydrogen Gas on Mouse Hind Limb Ischemia-Reperfusion Injury.
    The Journal of surgical research, 2021, Volume: 266

    Topics: Administration, Inhalation; Animals; Apoptosis; Biomarkers; Endoplasmic Reticulum Stress; Hindlimb;

2021
Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice.
    Life sciences, 2021, Aug-15, Volume: 279

    Topics: Acute Lung Injury; Animals; Extremities; Heme Oxygenase-1; Hydrogen; Male; Malondialdehyde; Mice; Mi

2021
Protective effects of hydrogen gas against spinal cord ischemia-reperfusion injury.
    The Journal of thoracic and cardiovascular surgery, 2022, Volume: 164, Issue:6

    Topics: Amino Acid Transport System X-AG; Animals; Disease Models, Animal; Glutamates; Hydrogen; Ischemia; M

2022
Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injury.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2017, 03-01, Volume: 51, Issue:3

    Topics: Animals; Antioxidants; Cytokines; Hydrogen; Inflammation Mediators; Lung; Lung Compliance; Organ Pre

2017
Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen‑activated protein kinase‑caspase‑3 signaling pathway following cerebral ischemia‑reperfusion injury.
    Molecular medicine reports, 2017, Volume: 16, Issue:4

    Topics: Animals; Apoptosis; Brain Ischemia; Caspase 3; Gene Expression; Hydrogen; Immunohistochemistry; Male

2017
Hydrogen-Rich Saline Ameliorates Hepatic Ischemia-Reperfusion Injury Through Regulation of Endoplasmic Reticulum Stress and Apoptosis.
    Digestive diseases and sciences, 2017, Volume: 62, Issue:12

    Topics: Animals; Apoptosis; Endoplasmic Reticulum Stress; Hepatic Insufficiency; Hydrogen; Liver; Male; Malo

2017
Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress.
    Life sciences, 2018, Feb-01, Volume: 194

    Topics: Animals; Apoptosis; Endoplasmic Reticulum Stress; Hydrogen; Liver; Liver Diseases; Protective Agents

2018
Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway.
    Biochemical and biophysical research communications, 2018, 01-22, Volume: 495, Issue:4

    Topics: Administration, Inhalation; Animals; Cell Survival; Hydrogen; Male; Phosphatidylinositol 3-Kinases;

2018
Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model.
    Artificial organs, 2018, Volume: 42, Issue:7

    Topics: Animals; Cold Ischemia; Disease Models, Animal; Hydrogen; Kidney; Kidney Transplantation; Oxidative

2018
Hydrogen-Rich Saline Attenuates Acute Lung Injury Induced by Limb Ischemia/Reperfusion via Down-Regulating Chemerin and NLRP3 in Rats.
    Shock (Augusta, Ga.), 2019, Volume: 52, Issue:1

    Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Chemokines; Enzyme-Linked Immunosorbent Assay; Hydro

2019
Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway.
    Brain research, 2018, 11-01, Volume: 1698

    Topics: Animals; Apoptosis; Autophagy; Brain Ischemia; Cell Survival; Hippocampus; Hydrogen; Membrane Potent

2018
Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study.
    Surgery today, 2018, Volume: 48, Issue:12

    Topics: Animals; Cell Death; Cold Temperature; Cytoplasm; Death; Gases; Graft Survival; Heart Arrest; Hydrog

2018
Effect of hydrogen-rich saline on apoptosis induced by hepatic ischemia reperfusion upon laparoscopic hepatectomy in miniature pigs.
    Research in veterinary science, 2018, Volume: 119

    Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Hepatectomy; Hydrogen; Laparo

2018
Hydrogen-rich saline protects rat from oxygen glucose deprivation and reperusion-induced apoptosis through VDAC1 via Bcl-2.
    Brain research, 2019, 03-01, Volume: 1706

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 9; Cell Death; Cell Hypoxia; Cell Survival;

2019
Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.
    BMC gastroenterology, 2019, Feb-08, Volume: 19, Issue:1

    Topics: Adenosine; Allopurinol; Animals; Apoptosis; Cold Temperature; Glutathione; Hepatocytes; Hydrogen; Hy

2019
Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model.
    Plastic and reconstructive surgery, 2017, Volume: 140, Issue:6

    Topics: Administration, Inhalation; Animals; Disease Models, Animal; Hindlimb; Humans; Hydrogen; Male; Mice;

2017
Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death.
    Microvascular research, 2019, Volume: 125

    Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Disease Mode

2019
UPLC-QTOF/MS-Based Metabolomics Reveals the Protective Mechanism of Hydrogen on Mice with Ischemic Stroke.
    Neurochemical research, 2019, Volume: 44, Issue:8

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Energy Metabolism; Glutathione; Hydrogen; Infa

2019
Preconditioning with one-time hydrogen gas does not attenuate skin flap ischemia-reperfusion injury in rat models.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2019, Volume: 72, Issue:10

    Topics: Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Epigastric Arteries; Graft Re

2019
Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits.
    Brain research, 2013, Jun-23, Volume: 1517

    Topics: Acyl Coenzyme A; Animals; Caspase 3; Catalase; Cytokines; Dinoprost; Disease Models, Animal; Dose-Re

2013
Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap.
    Journal of Zhejiang University. Science. B, 2013, Volume: 14, Issue:5

    Topics: Animals; Hydrogen; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Skin;

2013
Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression.
    Free radical biology & medicine, 2013, Volume: 65

    Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Hydrogen; Immunohistochemistry; In Situ Nick-End

2013
Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release.
    BMC gastroenterology, 2014, Jan-12, Volume: 14

    Topics: Alanine Transaminase; Animals; Down-Regulation; Guanosine; HMGB1 Protein; Hydrogen; Interleukin-6; L

2014
Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.
    Free radical biology & medicine, 2014, Volume: 69

    Topics: Animals; Female; Hippocampus; Humans; Hydrogen; Infant, Newborn; Lipid Peroxidation; Maternal-Fetal

2014
[Protective effects of hydrogen on renal ischemia/reperfusion injury in rats].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2014, Volume: 45, Issue:1

    Topics: Animals; Blood Urea Nitrogen; Creatinine; Hydrogen; Kidney; Male; Malondialdehyde; Nephrectomy; Rats

2014
Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass.
    Transplantation proceedings, 2014, Volume: 46, Issue:4

    Topics: Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Disease Models, Animal; Female; Gase

2014
Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats.
    The Journal of surgical research, 2014, Volume: 192, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Brain Ischemia; Calcium; Cell Survival; Cytochromes c; Hydrogen; I

2014
Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats.
    Transplantation, 2015, Volume: 99, Issue:3

    Topics: Administration, Inhalation; Administration, Oral; Animals; Antioxidants; Apoptosis; Cytokines; Gluco

2015
Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle.
    The Journal of surgical research, 2015, Volume: 194, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Autophagy; Drug Evaluation, Preclinical; Edema; Hydrogen; Male; Mu

2015
Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats.
    Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:9

    Topics: Animals; Antioxidants; Apoptosis; Cold Ischemia; Hydrogen; Lung Compliance; Lung Injury; Lung Transp

2015
[Role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion injury in rats].
    Zhonghua yi xue za zhi, 2015, Feb-10, Volume: 95, Issue:6

    Topics: Animals; Brain Ischemia; Forkhead Box Protein O3; Forkhead Transcription Factors; Hippocampus; Hydro

2015
Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury.
    Molecular medicine reports, 2015, Volume: 12, Issue:2

    Topics: Animals; Apoptosis; Caspase 3; DNA Fragmentation; Eosine Yellowish-(YS); Gene Expression Regulation;

2015
Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2015, Volume: 68, Issue:7

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Free Tissue Flaps; Hydrogen; Ischemia; Male; MAP Kin

2015
Antioxidants and K+ channel agonists versus hydrogen therapy during ex vivo lung perfusion†.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2016, Volume: 49, Issue:1

    Topics: Antioxidants; Extracorporeal Circulation; Humans; Hydrogen; Ischemic Preconditioning; Lung Transplan

2016
Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression.
    Toxicology letters, 2015, Nov-04, Volume: 238, Issue:3

    Topics: Animals; Apoptosis; Bile Ducts, Intrahepatic; Gene Silencing; Hydrogen; Liver Diseases; Male; NF-E2-

2015
Effects of intraperitoneal hydrogen injection on nitric oxide synthase mRNA and malondialdehyde following limb ischemia-reperfusion in rabbits.
    Acta orthopaedica et traumatologica turcica, 2015, Volume: 49, Issue:5

    Topics: Animals; Disease Models, Animal; Extremities; Hydrogen; Injections, Intraperitoneal; Male; Malondial

2015
Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia/reperfusion injury.
    Brain research, 2016, Feb-01, Volume: 1632

    Topics: Animals; Cell Survival; Disease Models, Animal; Hydrogen; Ischemic Postconditioning; Male; Rats; Rat

2016
Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats.
    Life sciences, 2016, Apr-15, Volume: 151

    Topics: Animals; Apoptosis; Blood Gas Analysis; Carbon Monoxide; Cold Ischemia; Drug Synergism; Hydrogen; In

2016
Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-κB Expression.
    Neurochemical research, 2016, Volume: 41, Issue:10

    Topics: Animals; Apoptosis; Brain Ischemia; Hippocampus; Hydrogen; Male; MicroRNAs; Neuroprotective Agents;

2016
Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats - A possible new hydrogen resource for clinical use.
    Neuroscience, 2016, Oct-29, Volume: 335

    Topics: Animals; Apoptosis; Brain; Brain Ischemia; Hydrogen; Male; Neurons; Neuroprotective Agents; Rats, Sp

2016
Protective effect of hydrogen rich saline solution on experimental ovarian ischemia reperfusion model in rats.
    Journal of pediatric surgery, 2017, Volume: 52, Issue:3

    Topics: Animals; Chi-Square Distribution; Female; Glutathione; Glutathione Transferase; Hydrogen; Male; Malo

2017
The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats.
    Turkish journal of medical sciences, 2016, Nov-17, Volume: 46, Issue:5

    Topics: Animals; Brain Ischemia; Heme Oxygenase-1; Hydrogen; Malondialdehyde; Neuroprotective Agents; Rats;

2016
Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2008, Volume: 8, Issue:10

    Topics: Administration, Inhalation; Animals; Antioxidants; Gases; Hydrogen; Inflammation; Intestines; Male;

2008
Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.
    Biochemical and biophysical research communications, 2009, Apr-17, Volume: 381, Issue:4

    Topics: Animals; Cell Membrane; Hydrogen; Interleukin-1beta; Intestines; Lipid Peroxidation; Lung Injury; Ma

2009
Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.
    Free radical research, 2009, Volume: 43, Issue:5

    Topics: Animals; Cytokines; Hydrogen; Inflammation; Inflammation Mediators; Infusions, Intravenous; Intestin

2009
Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.
    Medical hypotheses, 2010, Volume: 74, Issue:1

    Topics: Acute Radiation Syndrome; Antioxidants; Apoptosis; Free Radicals; Gases; Humans; Hydrogen; Hydroxyl

2010
Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Apoptosis; Biomarkers; Deoxyguanosine; Diffusion; D

2010
The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats.
    The Journal of surgical research, 2011, May-15, Volume: 167, Issue:2

    Topics: Animals; Apoptosis; Cell Proliferation; Hydrogen; Jejunum; Male; Models, Animal; Muscle Contraction;

2011
Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury.
    Journal of anesthesia, 2010, Volume: 24, Issue:4

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; Hydrogen; Kidney; Male; Rats; Rats, Wistar; Re

2010
Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury.
    Medical hypotheses, 2010, Volume: 75, Issue:6

    Topics: Administration, Oral; Bacteria; Humans; Hydrogen; Intestines; Mannitol; Reperfusion Injury

2010
Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats.
    Transplantation, 2010, Dec-27, Volume: 90, Issue:12

    Topics: Administration, Inhalation; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting,

2010
Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits.
    Brain research, 2011, Mar-10, Volume: 1378

    Topics: Animals; Antioxidants; Apoptosis; Cytokines; Hydrogen; In Situ Nick-End Labeling; Inflammation; Male

2011
Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats.
    The Journal of surgical research, 2011, May-15, Volume: 167, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cytokines; Deoxyguanosine; Disease Models, Animal; Hydrogen; K

2011
The effect of hydrogen-rich saline on the brain of rats with transient ischemia.
    The Journal of surgical research, 2011, Jun-01, Volume: 168, Issue:1

    Topics: Animals; Antioxidants; Caspase 3; Hippocampus; Hydrogen; Injections, Intraperitoneal; Interleukin-6;

2011
Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats.
    The British journal of nutrition, 2012, Volume: 107, Issue:4

    Topics: Amylose; Animals; Cecum; Fermentation; Glutathione; Hepatic Veno-Occlusive Disease; Hydrogen; Ischem

2012
Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits.
    The Journal of surgical research, 2012, May-01, Volume: 174, Issue:1

    Topics: Animals; Hydrogen; Interleukin-8; Lung; Male; Oxidative Stress; Pulmonary Edema; Pulmonary Gas Excha

2012
Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia.
    Shock (Augusta, Ga.), 2012, Volume: 37, Issue:6

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Inhalation; Animals; Body Water; Brain; Brain Ischemia;

2012
The potential benefits of hydrogen-rich saline in ischemia and reperfusion injury.
    The Journal of surgical research, 2013, Volume: 180, Issue:2

    Topics: Animals; Hydrogen; Lung; Male; Reperfusion Injury; Sodium Chloride

2013
Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats.
    Journal of pediatric surgery, 2012, Volume: 47, Issue:4

    Topics: Administration, Inhalation; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Biomarkers

2012
Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats.
    The Journal of urology, 2012, Volume: 187, Issue:6

    Topics: Animals; Antioxidants; Apoptosis; Hydrogen; Male; Protective Agents; Rats; Rats, Sprague-Dawley; Rep

2012
Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury.
    Transplantation, 2012, Jul-15, Volume: 94, Issue:1

    Topics: Adenosine; Allopurinol; Animals; Apoptosis; Cold Temperature; Glutathione; Graft Survival; Hydrogen;

2012
Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats.
    Heart, lung & circulation, 2012, Volume: 21, Issue:9

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Lung Injury; Animals; Biomarkers; Deoxyguanosine; Hydrogen; Male;

2012
Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement.
    Biochemical and biophysical research communications, 2012, Sep-07, Volume: 425, Issue:4

    Topics: Animals; CCAAT-Enhancer-Binding Proteins; Hydrogen; Lung; Lung Transplantation; Male; Pulmonary Surf

2012
Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia (Shock 37(6), 645-652, 2012).
    Shock (Augusta, Ga.), 2012, Volume: 38, Issue:4

    Topics: Animals; Brain Ischemia; Free Radical Scavengers; Hydrogen; Male; Mice; Reperfusion Injury

2012
Letter to the editor on "Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement".
    Biochemical and biophysical research communications, 2012, Oct-12, Volume: 427, Issue:1

    Topics: Animals; Hydrogen; Lung; Lung Transplantation; Male; Pulmonary Surfactant-Associated Proteins; Reper

2012
Hydrogen inhalation decreases lung graft injury in brain-dead donor rats.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2013, Volume: 32, Issue:2

    Topics: Acute Lung Injury; Animals; Antioxidants; Apoptosis; Brain Death; Caspase 1; Hydrogen; In Situ Nick-

2013
Role of Na+-H+ and Na+-Ca2+ exchange in hypoxia-related acute astrocyte death.
    Glia, 2005, Jan-01, Volume: 49, Issue:1

    Topics: Acute Disease; Animals; Astrocytes; Brain; Calcium; Calcium Signaling; Cell Death; Cell Hypoxia; Cel

2005
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Antioxidants; Cerebral Infarction; Disease Models, Animal; Huma

2007
The hydrogen highway to reperfusion therapy.
    Nature medicine, 2007, Volume: 13, Issue:6

    Topics: Animals; Antioxidants; Cells, Cultured; Disease Models, Animal; Humans; Hydrogen; Membrane Potential

2007
Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress.
    Biochemical and biophysical research communications, 2007, Sep-28, Volume: 361, Issue:3

    Topics: Administration, Inhalation; Animals; Hydrogen; Liver; Male; Mice; Oxidation-Reduction; Oxidative Str

2007
Impact of female sex hormones on liver tissue lactic acidosis during ischemia.
    Transplantation, 2007, Sep-27, Volume: 84, Issue:6

    Topics: Acidosis, Lactic; Animals; Estradiol; Female; Gonadal Steroid Hormones; Hydrogen; Lactic Acid; Liver

2007
A one-dimensional (proton and phosphorus) and two-dimensional (proton) in vivo NMR spectroscopic study of reversible global cerebral ischemia.
    Journal of neurochemistry, 1996, Volume: 66, Issue:6

    Topics: Animals; Brain Ischemia; Hydrogen; Magnetic Resonance Spectroscopy; Male; Phosphorus Isotopes; Prose

1996
Thermodiffusion for continuous quantification of hepatic microcirculation--validation and potential in liver transplantation.
    Microvascular research, 1999, Volume: 58, Issue:2

    Topics: Animals; Diffusion; Evaluation Studies as Topic; Hepatic Artery; Humans; Hydrogen; Liver; Liver Circ

1999
Actions of adenosine on nitro blue tetrazolium deposition and surface pH during intestinal reperfusion injury.
    Circulation research, 1990, Volume: 66, Issue:6

    Topics: Adenosine; Animals; Catalase; Hydrogen; Hydrogen-Ion Concentration; Intestines; Male; Nitroblue Tetr

1990