Page last updated: 2024-10-18

hydrogen and Hypoxia-Ischemia, Brain

hydrogen has been researched along with Hypoxia-Ischemia, Brain in 19 studies

Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.

Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"Hydrogen has neuroprotective effects against brain-related diseases."5.72Hydrogen Attenuated Inflammation Response and Oxidative in Hypoxic Ischemic Encephalopathy via Nrf2 Mediated the Inhibition of NLRP3 and NF-κB. ( Han, K; Hu, Y; Wang, P, 2022)
"Hydrogen has neuroprotective effects against brain-related diseases."1.72Hydrogen Attenuated Inflammation Response and Oxidative in Hypoxic Ischemic Encephalopathy via Nrf2 Mediated the Inhibition of NLRP3 and NF-κB. ( Han, K; Hu, Y; Wang, P, 2022)
"Hydrogen gas (H(2)) has been shown to ameliorate brain injury in experimental adult rat focal ischemia and in a mild neonatal hypoxia-ischemia (HI, 90 min hypoxia) rat model."1.35Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. ( Dorotta, IR; Fathali, N; Hasegawa, Y; Jadhav, V; Martin, RD; Matchett, GA; Ostrowski, RP; Sun, X; Zhang, JH, 2009)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (42.11)29.6817
2010's4 (21.05)24.3611
2020's7 (36.84)2.80

Authors

AuthorsStudies
Hu, Y1
Wang, P2
Han, K1
Nakamura, S4
Nakao, Y3
Htun, Y4
Mitsuie, T3
Koyano, K3
Morimoto, A2
Konishi, Y2
Arioka, M2
Kondo, S2
Kato, I2
Ohta, KI1
Yasuda, S2
Miki, T3
Ueno, M3
Kusaka, T4
Ohta, K2
Yokota, T1
Inoue, E1
Inoue, K1
Tsuchiya, T1
Kovács, V1
Remzső, G1
Tóth-Szűki, V2
Varga, V1
Németh, J1
Domoki, F3
Ke, H1
Liu, D1
Li, T1
Chu, X1
Xin, D1
Han, M1
Wang, S1
Wang, Z1
Nakamura, M1
Yamato, S1
Jinnai, W1
Wakabayashi, T1
Sugino, M1
Fujioka, K1
Wu, G1
Chen, Z1
Zhao, M1
Fujino, M1
Zhang, C1
Zhou, W1
Hirano, SI1
Li, XK1
Zhao, L1
Oláh, O1
Temesvári, P1
Bari, F1
Cai, J2
Kang, Z2
Liu, WW1
Luo, X2
Qiang, S1
Zhang, JH3
Ohta, S1
Sun, X3
Xu, W1
Tao, H1
Li, R2
Liu, K1
Liu, W1
Liu, L1
He, L1
Zheng, CX1
Matchett, GA1
Fathali, N1
Hasegawa, Y1
Jadhav, V1
Ostrowski, RP1
Martin, RD1
Dorotta, IR1
Alderliesten, T1
de Vries, LS1
Benders, MJ1
Koopman, C1
Groenendaal, F1
Vial, F1
Serriere, S1
Barantin, L1
Montharu, J1
Nadal-Desbarats, L1
Pourcelot, L1
Seguin, F1
Bondarenko, A1
Svichar, N1
Chesler, M1
Cheong, JL1
Cady, EB2
Penrice, J1
Wyatt, JS1
Cox, IJ1
Robertson, NJ1

Reviews

2 reviews available for hydrogen and Hypoxia-Ischemia, Brain

ArticleYear
Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.
    Pediatric research, 2021, Volume: 89, Issue:4

    Topics: Animals; Animals, Newborn; Antioxidants; Argon; Free Radicals; Gases; Humans; Hydrogen; Hypothermia,

2021
Hydrogen-induced Neuroprotection in Neonatal Hypoxic-ischemic Encephalopathy.
    Current pharmaceutical design, 2021, Volume: 27, Issue:5

    Topics: Animals; Humans; Hydrogen; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Neuroprot

2021

Trials

1 trial available for hydrogen and Hypoxia-Ischemia, Brain

ArticleYear
[Application of hydrogen proton magnetic resonance spectrum in hypoxic-ischemic encephalopathy in full-term neonates].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2008, Volume: 46, Issue:5

    Topics: Female; Humans; Hydrogen; Hypoxia-Ischemia, Brain; Infant, Newborn; Magnetic Resonance Spectroscopy;

2008

Other Studies

16 other studies available for hydrogen and Hypoxia-Ischemia, Brain

ArticleYear
Hydrogen Attenuated Inflammation Response and Oxidative in Hypoxic Ischemic Encephalopathy via Nrf2 Mediated the Inhibition of NLRP3 and NF-κB.
    Neuroscience, 2022, 03-01, Volume: 485

    Topics: Animals; Hydrogen; Hypoxia-Ischemia, Brain; Inflammation; Mice; NF-E2-Related Factor 2; NF-kappa B;

2022
Impact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and oxygenation in the asphyxiated piglet.
    Scientific reports, 2023, 01-28, Volume: 13, Issue:1

    Topics: Animals; Animals, Newborn; Hemodynamics; Hydrogen; Hypothermia; Hypothermia, Induced; Hypoxia-Ischem

2023
Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model.
    Scientific reports, 2023, 06-28, Volume: 13, Issue:1

    Topics: Albumins; Animals; Blood-Brain Barrier; Hydrogen; Hypoxia; Hypoxia-Ischemia, Brain; Swine

2023
Inhaled H
    International journal of molecular sciences, 2020, Sep-16, Volume: 21, Issue:18

    Topics: Acidosis; Administration, Inhalation; Animals; Animals, Newborn; Apoptosis Inducing Factor; Asphyxia

2020
Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Female; Hydrogen; Hypoxia-Ischemia, Br

2020
Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.
    Scientific reports, 2019, 03-11, Volume: 9, Issue:1

    Topics: Animals; Animals, Newborn; Antioxidants; Asphyxia Neonatorum; Brain; Disease Models, Animal; Humans;

2019
Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
    Experimental biology and medicine (Maywood, N.J.), 2019, Volume: 244, Issue:12

    Topics: Administration, Inhalation; Animals; Apoptosis; Brain Injuries; Female; Gene Expression Regulation;

2019
Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs.
    Neonatology, 2013, Volume: 104, Issue:2

    Topics: Animals; Animals, Newborn; Arterioles; Asphyxia Neonatorum; Blood Gas Analysis; Brain Waves; Disease

2013
Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model.
    Neuroscience letters, 2008, Aug-22, Volume: 441, Issue:2

    Topics: Animals; Animals, Newborn; Apoptosis; Caspase 12; Caspase 3; Cell Count; Cerebral Cortex; Disease Mo

2008
Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model.
    Brain research, 2009, Feb-23, Volume: 1256

    Topics: Animals; Animals, Newborn; Body Weight; Brain; Calcium-Binding Proteins; Caspase 3; Cell Death; Dise

2009
Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models.
    Brain research, 2009, Mar-09, Volume: 1259

    Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Brain; Disease Models, Animal; Hydroge

2009
MR imaging and outcome of term neonates with perinatal asphyxia: value of diffusion-weighted MR imaging and ¹H MR spectroscopy.
    Radiology, 2011, Volume: 261, Issue:1

    Topics: Asphyxia Neonatorum; Brain; Diffusion Magnetic Resonance Imaging; Female; Humans; Hydrogen; Hypoxia-

2011
A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI.
    Magnetic resonance imaging, 2004, Volume: 22, Issue:4

    Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cerebrovascular Circulatio

2004
Role of Na+-H+ and Na+-Ca2+ exchange in hypoxia-related acute astrocyte death.
    Glia, 2005, Jan-01, Volume: 49, Issue:1

    Topics: Acute Disease; Animals; Astrocytes; Brain; Calcium; Calcium Signaling; Cell Death; Cell Hypoxia; Cel

2005
Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7

    Topics: Aspartic Acid; Birth Injuries; Body Water; Brain; Brain Chemistry; Child Development; Choline; Creat

2006
Magnetic resonance spectroscopy in neonatal hypoxic-ischaemic insults.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2001, Volume: 17, Issue:3

    Topics: Brain; Developmental Disabilities; Humans; Hydrogen; Hypoxia-Ischemia, Brain; Infant, Newborn; Leuko

2001