Page last updated: 2024-10-18

hydrogen and Hypertension

hydrogen has been researched along with Hypertension in 39 studies

Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"The study was undertaken to determine the possible effect of an aldosterone antagonist, spironolactone (SP), on red blood cell sodium-hydrogen exchange (NHE) enhancement in primary aldosteronism (PA) and essential hypertension (EH)."9.08Spironolactone prevents Na+/H+ exchange enhancement in primary aldosteronism. ( Koldanov, R; Koren, W; Postnov, IY; Postnov, YV, 1997)
" An association has been described between increased sodium/hydrogen (Na+/H+) exchange rates in various cells and microalbuminuria in type 1 diabetic patients."7.69Characteristics of the sodium/hydrogen exchange in non-insulin-dependent diabetic patients with microalbuminuria and hypertension. ( Yudkin, JS; Zaidi, KF, 1996)
"Hypertension is one of the major issues worldwide and one of the main factors involved in heart and kidney failure."5.72Structural and dynamic investigation of non-synonymous variations in Renin-AGT complex revealed altered binding via hydrogen-bonding network reprogramming to accelerate the hypertension pathway. ( Ahmad, H; Khan, A; Khan, T; Tian, Z; Umbreen, S; Wei, DQ; Xuewei, Z, 2022)
"Hypertension is an important risk factor for death resulting from stroke, myocardial infarction, and end-stage renal failure."5.51Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. ( Hashimoto, K; Ichihara, M; Iwamoto, T; Kato, K; Matsuoka, H; Miyata, S; Nagahara, M; Noda, A; Okumura, N; Sobue, S; Takeda, K; Watanabe, T, 2019)
"In conclusion, HRS treatment attenuates left ventricular hypertrophy through abating oxidative stress, suppressing inflammatory process, preserving mitochondrial function, in which suppression of HRS on angiotensin II in left ventricles locally might be involved."5.38Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. ( Yu, YS; Zheng, H, 2012)
"The study was undertaken to determine the possible effect of an aldosterone antagonist, spironolactone (SP), on red blood cell sodium-hydrogen exchange (NHE) enhancement in primary aldosteronism (PA) and essential hypertension (EH)."5.08Spironolactone prevents Na+/H+ exchange enhancement in primary aldosteronism. ( Koldanov, R; Koren, W; Postnov, IY; Postnov, YV, 1997)
"Using 31-phosphorus magnetic resonance spectroscopy, pHi of the dominant flexor digitorum superficialis was measured in 20 Caucasian subjects (14 male) with essential hypertension and 20 normotensive controls matched for gender, age, race and body mass index."3.71In-vivo intracellular pH at rest and during exercise in patients with essential hypertension. ( Baker, EH; Griffiths, JR; Khong, TK; MacGregor, GA; Markandu, ND; McIntyre, DJ; Miller, MA; Sagnella, GA, 2001)
" An association has been described between increased sodium/hydrogen (Na+/H+) exchange rates in various cells and microalbuminuria in type 1 diabetic patients."3.69Characteristics of the sodium/hydrogen exchange in non-insulin-dependent diabetic patients with microalbuminuria and hypertension. ( Yudkin, JS; Zaidi, KF, 1996)
"Hypertension is one of the major issues worldwide and one of the main factors involved in heart and kidney failure."1.72Structural and dynamic investigation of non-synonymous variations in Renin-AGT complex revealed altered binding via hydrogen-bonding network reprogramming to accelerate the hypertension pathway. ( Ahmad, H; Khan, A; Khan, T; Tian, Z; Umbreen, S; Wei, DQ; Xuewei, Z, 2022)
"Hypertension is an important risk factor for death resulting from stroke, myocardial infarction, and end-stage renal failure."1.51Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. ( Hashimoto, K; Ichihara, M; Iwamoto, T; Kato, K; Matsuoka, H; Miyata, S; Nagahara, M; Noda, A; Okumura, N; Sobue, S; Takeda, K; Watanabe, T, 2019)
"In conclusion, HRS treatment attenuates left ventricular hypertrophy through abating oxidative stress, suppressing inflammatory process, preserving mitochondrial function, in which suppression of HRS on angiotensin II in left ventricles locally might be involved."1.38Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. ( Yu, YS; Zheng, H, 2012)
"Hypertension is an additional factor associated with a high degree of renal involvement in IDDM."1.29Platelet Na+/H+ antiport activity in patients with insulin-dependent diabetes mellitus with and without diabetic nephropathy. ( Düsing, R; Göbel, BO; Hoffmann, G; Mattes, L; Rosskopf, D; Siffert, W; Sorger, M; Vetter, H, 1993)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199015 (38.46)18.7374
1990's15 (38.46)18.2507
2000's2 (5.13)29.6817
2010's4 (10.26)24.3611
2020's3 (7.69)2.80

Authors

AuthorsStudies
Kawakami, K1
Matsuo, H1
Yamada, T1
Matsumoto, KI1
Sasaki, D1
Nomura, M1
Ahmad, H1
Khan, A1
Umbreen, S1
Khan, T1
Xuewei, Z1
Wei, DQ1
Tian, Z1
Yamamoto, H1
Ichikawa, Y1
Hirano, SI1
Sato, B1
Takefuji, Y1
Satoh, F1
Matsuoka, H1
Miyata, S1
Okumura, N1
Watanabe, T1
Hashimoto, K1
Nagahara, M1
Kato, K1
Sobue, S1
Takeda, K1
Ichihara, M1
Iwamoto, T1
Noda, A1
Jin, C1
Sun, J1
Stilphen, CA1
Smith, SM1
Ocasio, H1
Bermingham, B1
Darji, S1
Guha, A1
Patel, R1
Geurts, AM1
Jacob, HJ1
Lambert, NA1
O'Connor, PM1
Takeuchi, S1
Nagatani, K1
Otani, N1
Nawashiro, H1
Sugawara, T1
Wada, K1
Mori, K1
Yu, YS1
Zheng, H1
GERARD, R1
REDON, A1
BENYAMINE, R1
MOLINIER, A1
Navarro-Lopez, F1
Coca, A1
Pare, JC1
De La Sierra, A1
Bosch, X1
Urbano Marquez, A1
Scholz, TD1
Ceckler, TL1
Balaban, RS1
Düsing, R1
Sorger, M1
Mattes, L1
Göbel, BO1
Hoffmann, G1
Rosskopf, D1
Vetter, H1
Siffert, W1
Zaidi, KF1
Yudkin, JS1
Koren, W1
Koldanov, R1
Postnov, IY1
Postnov, YV1
Sakaeda, T1
Fukumura, K1
Takahashi, K1
Matsumura, S1
Matsuura, E1
Hirano, K1
Khong, TK1
McIntyre, DJ1
Sagnella, GA1
Markandu, ND1
Miller, MA1
Baker, EH1
Griffiths, JR1
MacGregor, GA1
Yasuda, T1
Shigematsu, J1
Tobimatsu, S1
Takahashi, S1
Kato, M1
Moggio, RA1
Hammond, GL1
Cloix, JF1
Le Jossec, M1
Baud, O1
Pecquery, R1
Giudicelli, Y1
Dausse, JP1
Acra, S1
Ghishan, FK1
Syme, PD1
Aronson, JK1
Thompson, CH1
Williams, EM1
Green, Y1
Radda, GK2
Semplicini, A1
Ceolotto, G1
Marzola, M1
Delva, P1
Pastori, C1
Degan, M1
Zamboni, M1
Arosio, E1
Lechi, C1
Guzzo, P1
Armellini, F1
Lechi, A1
Strazzullo, P1
de Simone, G1
Celentano, A1
Iacone, R1
Ragone, E1
Pagano, E1
Tammaro, P1
Canessa, M1
Nosadini, R1
Crepaldi, G1
D'Angelo, A1
Kobayashi, A1
Nara, Y1
Nishio, T1
Mori, C1
Yamori, Y1
Dudley, CR1
Taylor, DJ1
Ng, LL1
Kemp, GJ1
Ratcliffe, PJ1
Ledingham, JG1
Astarie, C1
Levenson, J1
Simon, A1
Meyer, P1
Devynck, MA1
Smith, JM1
Cragoe, EJ1
Jones, AW1
Thorén, P1
Westling, H1
Skarphedinsson, JO1
Livne, A2
Balfe, JW1
Veitch, R1
Marquez-Julio, A1
Grinstein, S1
Rothstein, A1
Stokes, GS1
Monaghan, JC1
Marwood, JF1
Aviv, A2
Mahnensmith, RL1
Aronson, PS1
Weissberg, PL1
Little, PJ1
Bobik, A1
Pokudin, NI1
Orlov, SN1
Postnov, IuV1
Meyer, JS1
Welch, KM1
Koberstein, RC1
Pittman, DE1
Klocke, FJ1
Grünfeld, JP1
Raphaël, JC1
Bankir, L1
Kleinknecht, D1
Barger, AC1

Reviews

8 reviews available for hydrogen and Hypertension

ArticleYear
Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases.
    International journal of molecular sciences, 2021, Jul-05, Volume: 22, Issue:13

    Topics: Alzheimer Disease; Animals; Asymptomatic Diseases; Chronic Disease; Diabetes Mellitus, Type 2; Free

2021
[Na+/H+ exchangers, alpha-2-adrenergic receptors, sodium sensitivity and arterial hypertension].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1992, Volume: 186, Issue:4

    Topics: Animals; Drug Resistance; Hydrogen; Hypertension; Ion Transport; Rats; Rats, Inbred Strains; Recepto

1992
[Erythrocyte Na+/H+ exchange and arterial hypertension].
    Giornale italiano di cardiologia, 1991, Volume: 21, Issue:12

    Topics: Bicarbonates; Biochemical Phenomena; Biochemistry; Electrochemistry; Erythrocytes; Humans; Hydrogen;

1991
The link between cytosolic Ca2+ and the Na+-H+ antiport: a unifying factor for essential hypertension.
    Journal of hypertension, 1988, Volume: 6, Issue:9

    Topics: Animals; Atrial Natriuretic Factor; Biological Transport; Calcium; Cytosol; Dopamine; Humans; Hydrog

1988
The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes.
    Circulation research, 1985, Volume: 56, Issue:6

    Topics: Acid-Base Equilibrium; Animals; Biological Transport, Active; Blood Platelets; Calcium; Carrier Prot

1985
The Na+/H+ antiport, cytosolic free Ca2+, and essential hypertension: a hypothesis.
    American journal of hypertension, 1988, Volume: 1, Issue:4 Pt 1

    Topics: Biological Transport; Calcium; Humans; Hydrogen; Hypertension; Models, Biological; Renin; Sodium; So

1988
Relationship of cerebral blood flow and metabolism to neurological symptoms.
    Progress in brain research, 1972, Volume: 35

    Topics: Acetylcholine; Animals; Autoradiography; Blood Flow Velocity; Blood Gas Analysis; Brain; Carbon Diox

1972
Intrarenal distribution of blood flow.
    Advances in nephrology from the Necker Hospital, 1971, Volume: 1

    Topics: Acute Kidney Injury; Aminohippuric Acids; Animals; Blood Flow Velocity; Calorimetry; Dogs; Glomerula

1971

Trials

1 trial available for hydrogen and Hypertension

ArticleYear
Spironolactone prevents Na+/H+ exchange enhancement in primary aldosteronism.
    American journal of hypertension, 1997, Volume: 10, Issue:3

    Topics: Adult; Blood Pressure; Erythrocytes; Female; Humans; Hydrogen; Hyperaldosteronism; Hypertension; Mal

1997

Other Studies

30 other studies available for hydrogen and Hypertension

ArticleYear
Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats.
    Experimental animals, 2022, Aug-05, Volume: 71, Issue:3

    Topics: Animals; Ascorbic Acid; Hydrogen; Hypertension; Rats; Rats, Inbred SHR; Sodium Chloride; Water

2022
Structural and dynamic investigation of non-synonymous variations in Renin-AGT complex revealed altered binding via hydrogen-bonding network reprogramming to accelerate the hypertension pathway.
    Chemical biology & drug design, 2022, Volume: 100, Issue:5

    Topics: Angiotensinogen; Humans; Hydrogen; Hypertension; Renin; Renin-Angiotensin System

2022
Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2019, Volume: 41, Issue:4

    Topics: Animals; Blood Pressure; Echocardiography; Gases; Hydrogen; Hypertension; Hypertrophy, Left Ventricu

2019
HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.
    Hypertension (Dallas, Tex. : 1979), 2014, Volume: 64, Issue:3

    Topics: Animals; Disease Models, Animal; Hydrogen; Hydrogen-Ion Concentration; Hypertension; Ion Channels; K

2014
Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats.
    BMC neuroscience, 2015, Apr-20, Volume: 16

    Topics: Administration, Oral; Albumins; Animals; Blood Pressure; Blood-Brain Barrier; Body Weight; Cerebral

2015
Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats.
    Molecular and cellular biochemistry, 2012, Volume: 365, Issue:1-2

    Topics: Angiotensin II; Animals; Antioxidants; Catalase; Cytokines; Electron Transport Chain Complex Protein

2012
[DETERMINATION OF LEFT-RIGHT SHUNTS BY THE HYDROGEN METHOD].
    Archives des maladies du coeur et des vaisseaux, 1964, Volume: 57

    Topics: Angiocardiography; Cardiac Catheterization; Heart Defects, Congenital; Heart Septal Defects; Humans;

1964
Left ventricular hypertrophy in asymptomatic essential hypertension: its relationship with aldosterone and the increase in sodium-proton exchanger activity.
    European heart journal, 1993, Volume: 14 Suppl J

    Topics: Adult; Age Factors; Aldosterone; Blood Pressure; Case-Control Studies; Erythrocytes; Female; Humans;

1993
Magnetization transfer characterization of hypertensive cardiomyopathy: significance of tissue water content.
    Magnetic resonance in medicine, 1993, Volume: 29, Issue:3

    Topics: Age Factors; Animals; Body Water; Body Weight; Cardiomyopathy, Hypertrophic; Desiccation; Electron S

1993
Platelet Na+/H+ antiport activity in patients with insulin-dependent diabetes mellitus with and without diabetic nephropathy.
    The Clinical investigator, 1993, Volume: 71, Issue:2

    Topics: Adult; Blood Platelets; Blood Pressure; Body Mass Index; Carrier Proteins; Diabetes Mellitus, Type 1

1993
Characteristics of the sodium/hydrogen exchange in non-insulin-dependent diabetic patients with microalbuminuria and hypertension.
    Clinical science (London, England : 1979), 1996, Volume: 90, Issue:1

    Topics: Albuminuria; Blood Platelets; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Hyd

1996
Blood flow rate in normal and tumor-bearing rats in conscious state, under urethane anesthesia, and during systemic hypothermia.
    Journal of drug targeting, 1998, Volume: 6, Issue:4

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Angiotensin II; Animals; Cardiac Output; Ceftazid

1998
In-vivo intracellular pH at rest and during exercise in patients with essential hypertension.
    Journal of hypertension, 2001, Volume: 19, Issue:9

    Topics: Exercise; Female; Humans; Hydrogen; Hydrogen-Ion Concentration; Hypertension; Intracellular Membrane

2001
Persistent hypertension does not alter the cerebral blood flow and glucose utilization in young-adult Dahl salt-sensitive rats.
    Journal of the neurological sciences, 2002, May-15, Volume: 197, Issue:1-2

    Topics: Animals; Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Deoxyglucose; Diet, Sodium-Restri

2002
Distribution of myocardial blood flow measured by hydrogen polarography.
    Annals of surgery, 1976, Volume: 183, Issue:3

    Topics: Animals; Coronary Circulation; Dogs; Hydrogen; Hyperemia; Hypertension; Vectorcardiography

1976
Increased Na(+)-H+ exchange in jejunal brush border membrane vesicles of spontaneously hypertensive rats.
    Gastroenterology, 1991, Volume: 101, Issue:2

    Topics: Amiloride; Animals; Biological Transport, Active; Carrier Proteins; Hydrogen; Hydrogen-Ion Concentra

1991
Na+/H+ and HCO3-/Cl- exchange in the control of intracellular pH in vivo in the spontaneously hypertensive rat.
    Clinical science (London, England : 1979), 1991, Volume: 81, Issue:6

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo

1991
Erythrocyte Na(+)-H+ exchange activity in a group of essential hypertensive patients.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1991, Volume: 9, Issue:6

    Topics: Adult; Carrier Proteins; Erythrocyte Membrane; Humans; Hydrogen; Hypertension; Ion Exchange; Middle

1991
Sodium-hydrogen exchange and cardiac hypertrophy in patients with primary hypertension.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1991, Volume: 9, Issue:6

    Topics: Adult; Cardiomegaly; Carrier Proteins; Female; Humans; Hydrogen; Hypertension; Ion Exchange; Lymphoc

1991
Diabetes mellitus and hypertension: a physiologic basis for a rational therapeutic approach.
    American heart journal, 1991, Volume: 121, Issue:4 Pt 2

    Topics: Antihypertensive Agents; Biological Transport; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2;

1991
Increased Na(+)-H+ exchange activity in cultured vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats.
    Journal of hypertension, 1990, Volume: 8, Issue:2

    Topics: Animals; Cells, Cultured; Cerebrovascular Disorders; Cytoplasm; Fluoresceins; Hydrogen; Hydrogen-Ion

1990
Evidence for abnormal Na+/H+ antiport activity detected by phosphorus nuclear magnetic resonance spectroscopy in exercising skeletal muscle of patients with essential hypertension.
    Clinical science (London, England : 1979), 1990, Volume: 79, Issue:5

    Topics: Biological Transport, Active; Cell Membrane; Cells, Cultured; Female; Forearm; Humans; Hydrogen; Hyd

1990
Platelet cytosolic proton and free calcium concentrations in essential hypertension.
    Journal of hypertension, 1989, Volume: 7, Issue:6

    Topics: Adult; Benzofurans; Blood Platelets; Calcium; Cytosol; Female; Fluoresceins; Fura-2; Humans; Hydroge

1989
Nisoldipine inhibition of sodium influx into aorta from aldosterone-salt-hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1989, Volume: 13, Issue:6 Pt 2

    Topics: Aldosterone; Animals; Aorta; Calcium; Calcium Channel Blockers; Hydrogen; Hypertension; Ion Exchange

1989
Effect of the calcium antagonists felodipine and nimodipine on cortical blood flow in the spontaneously hypertensive rat.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1989, Volume: 7, Issue:4

    Topics: Animals; Blood Pressure; Cerebral Cortex; Felodipine; Homeostasis; Hydrogen; Hypertension; Male; Nim

1989
Increased platelet Na+-H+ exchange rates in essential hypertension: application of a novel test.
    Lancet (London, England), 1987, Mar-07, Volume: 1, Issue:8532

    Topics: Blood Platelets; Evaluation Studies as Topic; Female; Humans; Hydrogen; Hypertension; Ion Exchange;

1987
The Na+-H+ antiport in essential hypertension.
    Lancet (London, England), 1987, Jun-27, Volume: 1, Issue:8548

    Topics: Biological Transport; Blood Platelets; Cations; Erythrocytes; Humans; Hydrogen; Hypertension; Male;

1987
Glimpses of the mechanisms of hypertension.
    British medical journal (Clinical research ed.), 1986, Nov-29, Volume: 293, Issue:6559

    Topics: Humans; Hydrogen; Hypertension; Sodium

1986
[Characteristics of Na+/H+ metabolism in the erythrocytes of rats with spontaneous hypertension].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 104, Issue:10

    Topics: Amiloride; Animals; Erythrocyte Deformability; Erythrocytes; Hydrogen; Hypertension; Male; Potassium

1987
Right atrial admixture in coronary venous blood.
    The American journal of physiology, 1969, Volume: 216, Issue:3

    Topics: Animals; Blood Gas Analysis; Cardiac Catheterization; Chromatography, Gas; Coronary Vessels; Deuteri

1969