hydrogen has been researched along with Hyperoxia in 11 studies
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.
Hyperoxia: An abnormal increase in the amount of oxygen in the tissues and organs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Purpose/Aim: Exposure to hyperoxia leads to lung injury both in vivo and in vitro, molecular hydrogen has been reported to protect against hyperoxia-induced lung injury; however, the underlying molecular mechanisms remain largely unknown." | 7.88 | Quantitative proteomics reveals the mechanisms of hydrogen-conferred protection against hyperoxia-induced injury in type II alveolar epithelial cells. ( Lu, X; Wang, C; Wu, D; Xiao, C; Xu, F; Zhang, C, 2018) |
| "Inhaled hydrogen gas (H2) provides protection in rat models of human acute lung injury (ALI)." | 7.85 | Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging. ( Audi, SH; Camara, AKS; Clough, AV; Jacobs, ER; Medhora, MM; Rizzo, B; Zhang, X; Zhao, M, 2017) |
| "Hydrogen saline may be a potential treatment for hyperoxia-induced retinopathy that acts via the inhibition of oxidative stress and the reduction of VEGF expression." | 7.78 | Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression. ( Huang, L; Sun, X; Zhang, JH; Zhao, S, 2012) |
| "Sepsis is the most common cause of death in intensive care units." | 5.38 | Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. ( Chen, H; Fu, W; Han, H; Li, A; Wang, G; Xie, K; Xing, W; Yu, Y, 2012) |
| "Purpose/Aim: Exposure to hyperoxia leads to lung injury both in vivo and in vitro, molecular hydrogen has been reported to protect against hyperoxia-induced lung injury; however, the underlying molecular mechanisms remain largely unknown." | 3.88 | Quantitative proteomics reveals the mechanisms of hydrogen-conferred protection against hyperoxia-induced injury in type II alveolar epithelial cells. ( Lu, X; Wang, C; Wu, D; Xiao, C; Xu, F; Zhang, C, 2018) |
| "Inhaled hydrogen gas (H2) provides protection in rat models of human acute lung injury (ALI)." | 3.85 | Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging. ( Audi, SH; Camara, AKS; Clough, AV; Jacobs, ER; Medhora, MM; Rizzo, B; Zhang, X; Zhao, M, 2017) |
| " Hypoxia or endotoxin application did not exert any effect, whilst pure oxygen inhalation reduced deuterium oxidation." | 3.81 | The Evaluation and Quantitation of Dihydrogen Metabolism Using Deuterium Isotope in Rats. ( Galkin, A; Hyspler, R; Schierbeek, H; Ticha, A; Zadak, Z, 2015) |
| "Hydrogen saline may be a potential treatment for hyperoxia-induced retinopathy that acts via the inhibition of oxidative stress and the reduction of VEGF expression." | 3.78 | Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression. ( Huang, L; Sun, X; Zhang, JH; Zhao, S, 2012) |
| "The results of this study demonstrate that hydrogen-rich saline ameliorated hyperoxia-induced acute lung injury by reducing oxidative stress and inflammatory cascades in lung tissue." | 3.77 | Hydrogen-rich saline provides protection against hyperoxic lung injury. ( Cai, J; Liu, S; Liu, Y; Sun, Q; Sun, X; Tao, H; Xu, W, 2011) |
| "Hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression." | 1.39 | Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. ( Billiar, TR; Huang, CS; Kawamura, T; Kensler, TW; Masutani, K; Nakao, A; Noda, K; Okumura, M; Peng, X; Shigemura, N; Takahashi, T; Tanaka, Y; Toyoda, Y; Wakabayashi, N, 2013) |
| "Sepsis is the most common cause of death in intensive care units." | 1.38 | Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. ( Chen, H; Fu, W; Han, H; Li, A; Wang, G; Xie, K; Xing, W; Yu, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Q | 2 |
| Han, W | 1 |
| Hu, H | 1 |
| Fan, D | 1 |
| Li, Y | 1 |
| Zhang, Y | 1 |
| Lv, Y | 1 |
| Li, M | 1 |
| Pan, S | 1 |
| Audi, SH | 1 |
| Jacobs, ER | 1 |
| Zhang, X | 1 |
| Camara, AKS | 1 |
| Zhao, M | 1 |
| Medhora, MM | 1 |
| Rizzo, B | 1 |
| Clough, AV | 1 |
| Wu, D | 2 |
| Liang, M | 1 |
| Dang, H | 1 |
| Fang, F | 1 |
| Xu, F | 2 |
| Liu, C | 1 |
| Lu, X | 1 |
| Wang, C | 1 |
| Zhang, C | 1 |
| Xiao, C | 1 |
| Kawamura, T | 1 |
| Wakabayashi, N | 1 |
| Shigemura, N | 1 |
| Huang, CS | 1 |
| Masutani, K | 1 |
| Tanaka, Y | 1 |
| Noda, K | 1 |
| Peng, X | 1 |
| Takahashi, T | 1 |
| Billiar, TR | 1 |
| Okumura, M | 1 |
| Toyoda, Y | 1 |
| Kensler, TW | 1 |
| Nakao, A | 1 |
| Hyspler, R | 1 |
| Ticha, A | 1 |
| Schierbeek, H | 1 |
| Galkin, A | 1 |
| Zadak, Z | 1 |
| Cai, J | 1 |
| Liu, S | 1 |
| Liu, Y | 1 |
| Xu, W | 1 |
| Tao, H | 1 |
| Sun, X | 2 |
| Huang, L | 1 |
| Zhao, S | 1 |
| Zhang, JH | 1 |
| Xie, K | 1 |
| Fu, W | 1 |
| Xing, W | 1 |
| Li, A | 1 |
| Chen, H | 1 |
| Han, H | 1 |
| Yu, Y | 1 |
| Wang, G | 1 |
| Naoki, K | 1 |
| Kudo, H | 1 |
| Suzuki, K | 1 |
| Takeshita, K | 1 |
| Miyao, N | 1 |
| Ishii, M | 1 |
| Sato, N | 1 |
| Suzuki, Y | 1 |
| Tsumura, H | 1 |
| Yamaguchi, K | 1 |
| Kerbaul, F | 1 |
| Bellezza, M | 1 |
| Guidon, C | 1 |
| Roussel, L | 1 |
| Imbert, M | 1 |
| Carpentier, JP | 1 |
| Auffray, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Hydrogen Inhalation on Bronchiectasis (HYBRID): A Randomized, Multi-center, Double-blind, Parallel-group Study[NCT02765295] | 120 participants (Anticipated) | Interventional | 2016-06-01 | Recruiting | |||
| Adjuvant Therapy for Severe COPD Patients in the Stable Phase by an Oxyhydrogen Generator With Nebulizer: A Multi-centric, Randomized, Parallel-control and Double-blinded Clinic Study[NCT02850185] | 170 participants (Anticipated) | Interventional | 2016-07-15 | Recruiting | |||
| Adjuvant Therapy for Severe Asthma by an Oxyhydrogen Generator With Nebulizer: A Multi-centric, Randomized, Parallel-control and Double-blinded Clinic Study on Effectiveness and Safety[NCT02883582] | 150 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | |||
| Evaluation of the Daily Intake of 0.5 L of Water Saturated With Molecular Hydrogen for 21 Days in COVID-19 Patients Treated in Ambulatory Care. Double-blind, Randomized, Comparative Study[NCT04716985] | 700 participants (Actual) | Interventional | 2021-01-22 | Active, not recruiting | |||
| A Randomized Pilot Clinical Trial of the Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction of Sevoflurane in Patient's Whit ARDS Secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2)[NCT04998253] | Early Phase 1 | 24 participants (Actual) | Interventional | 2020-10-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for hydrogen and Hyperoxia
| Article | Year |
|---|---|
Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1.
Topics: Acute Lung Injury; Animals; Apoptosis; Carbazoles; Endoplasmic Reticulum Stress; Enzyme Activation; | 2017 |
Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Bacteriocins; Disease Models, Animal; Hydrog | 2017 |
Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Apoptosis; bcl-2-Associated X Protein; Bcl-2- | 2018 |
Quantitative proteomics reveals the mechanisms of hydrogen-conferred protection against hyperoxia-induced injury in type II alveolar epithelial cells.
Topics: Acute Lung Injury; Animals; Apoptosis; Cell Transdifferentiation; Chromatography, Liquid; Epithelial | 2018 |
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla | 2013 |
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla | 2013 |
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla | 2013 |
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla | 2013 |
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla | 2013 |
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla | 2013 |
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla | 2013 |
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla | 2013 |
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla | 2013 |
The Evaluation and Quantitation of Dihydrogen Metabolism Using Deuterium Isotope in Rats.
Topics: Animals; Antioxidants; Ascitic Fluid; Body Water; Carbon Monoxide; Cattle; Deuterium; Drug Evaluatio | 2015 |
Hydrogen-rich saline provides protection against hyperoxic lung injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj | 2011 |
Hydrogen-rich saline provides protection against hyperoxic lung injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj | 2011 |
Hydrogen-rich saline provides protection against hyperoxic lung injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj | 2011 |
Hydrogen-rich saline provides protection against hyperoxic lung injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj | 2011 |
Hydrogen-rich saline provides protection against hyperoxic lung injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj | 2011 |
Hydrogen-rich saline provides protection against hyperoxic lung injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj | 2011 |
Hydrogen-rich saline provides protection against hyperoxic lung injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj | 2011 |
Hydrogen-rich saline provides protection against hyperoxic lung injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj | 2011 |
Hydrogen-rich saline provides protection against hyperoxic lung injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj | 2011 |
Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression.
Topics: Animals; Antioxidants; Disease Models, Animal; Hydrogen; Hyperoxia; Malondialdehyde; Mice; Oxidative | 2012 |
Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis.
Topics: Alanine Transaminase; Animals; Catalase; Coinfection; Cytokines; Dinoprost; Disease Models, Animal; | 2012 |
NOS and COX isoforms and abnormal microvessel responses to CO2 and H+ in hyperoxia-injured lungs.
Topics: Acidosis, Respiratory; Animals; Carbon Dioxide; Disease Models, Animal; Hydrogen; Hypercapnia; Hyper | 2002 |
Effects of sevoflurane on hypoxic pulmonary vasoconstriction in anaesthetized piglets.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Blood Pressure; Carbon Dioxide; Hydrogen; | 2000 |