Page last updated: 2024-10-18

hydrogen and Hepatic Encephalopathy

hydrogen has been researched along with Hepatic Encephalopathy in 8 studies

Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"To investigate the metabolic changes in type C hepatic encephalopathy (CHE) rats after reducing manganese (Mn) intake."8.12Metabolic changes of the reduction of manganese intake in the hepatic encephalopathy rat: NMR- and MS-based metabolomics study. ( Li, Y; Lu, J; Qiang, J; Yang, X; Zhang, C, 2022)
"22 healthy controls and 52 patients with liver cirrhosis (16 with hepatic encephalopathy) were prospectively studied by means of lactulose or lactose hydrogen breath tests and lactose tolerance test."7.68[Lactulose fermentation and lactose absorption in Chilean patients with liver cirrhosis: importance for hepatic encephalopathy therapy]. ( Alegría, S; Antezana, C; Chesta, J, 1993)
"Overt hepatic encephalopathy (HE) is one of the complications of liver cirrhosis (LC), which negatively affects the prognosis and quality of life of patients."7.11Hydrogen-producing small intestinal bacterial overgrowth is associated with hepatic encephalopathy and liver function. ( Abe, H; Kamimura, K; Kawata, Y; Naruse, T; Sakamaki, A; Sato, C; Sato, H; Takahashi, K; Takamura, M; Terai, S; Tominaga, K; Tsuchiya, A; Yokoyama, J; Yokoyama, K, 2022)
"To investigate the metabolic changes in type C hepatic encephalopathy (CHE) rats after reducing manganese (Mn) intake."4.12Metabolic changes of the reduction of manganese intake in the hepatic encephalopathy rat: NMR- and MS-based metabolomics study. ( Li, Y; Lu, J; Qiang, J; Yang, X; Zhang, C, 2022)
"22 healthy controls and 52 patients with liver cirrhosis (16 with hepatic encephalopathy) were prospectively studied by means of lactulose or lactose hydrogen breath tests and lactose tolerance test."3.68[Lactulose fermentation and lactose absorption in Chilean patients with liver cirrhosis: importance for hepatic encephalopathy therapy]. ( Alegría, S; Antezana, C; Chesta, J, 1993)
"Overt hepatic encephalopathy (HE) is one of the complications of liver cirrhosis (LC), which negatively affects the prognosis and quality of life of patients."3.11Hydrogen-producing small intestinal bacterial overgrowth is associated with hepatic encephalopathy and liver function. ( Abe, H; Kamimura, K; Kawata, Y; Naruse, T; Sakamaki, A; Sato, C; Sato, H; Takahashi, K; Takamura, M; Terai, S; Tominaga, K; Tsuchiya, A; Yokoyama, J; Yokoyama, K, 2022)
"Human hepatic encephalopathy (HE) is identified by a new noninvasive test, proton magnetic resonance spectroscopy (1H MRS) applied to the brain in a few minutes."2.39Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy? ( Blüml, S; Danielsen, ER; Ross, BD, 1996)
"This may result in Hepatic Encephalopathy (HE), a spectrum of neuro-psychiatric abnormalities which include changes in cognitive functions, consciousness, and behaviour."1.51An E-Nose for the Monitoring of Severe Liver Impairment: A Preliminary Study. ( Brunetto, M; Colantonio, S; D'Acunto, M; Germanese, D; Romagnoli, V; Salvati, A, 2019)
"In alcoholic patients with hepatic encephalopathy, there was no such correlation."1.331H-MR spectroscopy, magnetization transfer, and diffusion-weighted imaging in alcoholic and nonalcoholic patients with cirrhosis with hepatic encephalopathy. ( Cohnen, M; Häussinger, D; Hemker, J; Kircheis, G; Miese, F; Mödder, U; Wenserski, F; Wittsack, HJ, 2006)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's2 (25.00)18.2507
2000's1 (12.50)29.6817
2010's2 (25.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Yokoyama, K1
Sakamaki, A1
Takahashi, K1
Naruse, T1
Sato, C1
Kawata, Y1
Tominaga, K1
Abe, H1
Sato, H1
Tsuchiya, A1
Kamimura, K1
Takamura, M1
Yokoyama, J1
Terai, S1
Lu, J1
Li, Y1
Zhang, C1
Yang, X1
Qiang, J1
Germanese, D1
Colantonio, S1
D'Acunto, M1
Romagnoli, V1
Salvati, A1
Brunetto, M1
Qu, J1
Lü, X1
Miese, F1
Kircheis, G1
Wittsack, HJ1
Wenserski, F1
Hemker, J1
Mödder, U1
Häussinger, D1
Cohnen, M1
Chesta, J1
Antezana, C1
Alegría, S1
Ross, BD1
Danielsen, ER1
Blüml, S1
Zweig, JI1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205]40 participants (Anticipated)Observational2019-06-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for hydrogen and Hepatic Encephalopathy

ArticleYear
Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy?
    Digestive diseases (Basel, Switzerland), 1996, Volume: 14 Suppl 1

    Topics: Animals; Astrocytes; Brain; Choline; Cognition Disorders; Disease Models, Animal; Glutamine; Hepatic

1996
Effects of lysine on ammonia formation, hydrogen ion, and potassium ion balance: a review and an hypothesis.
    Clinical chemistry, 1973, Volume: 19, Issue:9

    Topics: Acid-Base Equilibrium; Adolescent; Adult; Ammonia; Animals; Arginine; Biological Transport; Cystinur

1973

Trials

1 trial available for hydrogen and Hepatic Encephalopathy

ArticleYear
Hydrogen-producing small intestinal bacterial overgrowth is associated with hepatic encephalopathy and liver function.
    PloS one, 2022, Volume: 17, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Breath Tests; Female; Gastrointestinal Microbiome; Hepatic Encephalo

2022

Other Studies

5 other studies available for hydrogen and Hepatic Encephalopathy

ArticleYear
Metabolic changes of the reduction of manganese intake in the hepatic encephalopathy rat: NMR- and MS-based metabolomics study.
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2022, Volume: 35, Issue:5

    Topics: Amino Acids; Ammonia; Animals; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Hepatic Encephalop

2022
An E-Nose for the Monitoring of Severe Liver Impairment: A Preliminary Study.
    Sensors (Basel, Switzerland), 2019, Aug-22, Volume: 19, Issue:17

    Topics: Breath Tests; Carbon Monoxide; Electronic Nose; Gases; Hepatic Encephalopathy; Humans; Hydrogen; Liv

2019
Hydrogen: a promising novel treatment for hepatic encephalopathy?
    Free radical biology & medicine, 2013, Volume: 63

    Topics: Ammonia; Hepatic Encephalopathy; Humans; Hydrogen; Liver Diseases

2013
1H-MR spectroscopy, magnetization transfer, and diffusion-weighted imaging in alcoholic and nonalcoholic patients with cirrhosis with hepatic encephalopathy.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:5

    Topics: Diffusion Magnetic Resonance Imaging; Female; Hepatic Encephalopathy; Humans; Hydrogen; Liver Cirrho

2006
[Lactulose fermentation and lactose absorption in Chilean patients with liver cirrhosis: importance for hepatic encephalopathy therapy].
    Revista medica de Chile, 1993, Volume: 121, Issue:5

    Topics: Adolescent; Adult; Aged; Case-Control Studies; Child; Chile; Female; Fermentation; Hepatic Encephalo

1993