hydrogen has been researched along with Gastric Stasis in 3 studies
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Overall, 79 (39 %) patients with gastroparesis had evidence of SIBO by LBT: 30 (15 %) had positive H2@90min, 53 (26 %) positive DPHBT, and 6 (3 %) positive breath methane test." | 3.80 | Small intestinal bacterial overgrowth in gastroparesis. ( George, NS; Parkman, HP; Sankineni, A, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reddymasu, SC | 1 |
| McCallum, RW | 1 |
| George, NS | 1 |
| Sankineni, A | 1 |
| Parkman, HP | 1 |
| Burge, MR | 1 |
| Tuttle, MS | 1 |
| Violett, JL | 1 |
| Stephenson, CL | 1 |
| Schade, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Autonomic Neuropathy, Gastrointestinal Motility, and Inflammation in HIV[NCT02850276] | Early Phase 1 | 76 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Number of participants with reduction in Small intestinal bacterial overgrowth (SIBO) assessed with breath testing after 8 weeks of treatment.~The hydrogen breath test for the detection of small intestinal bacterial overgrowth (SIBO), obtained by having participants exhale into a plastic bag. the hydrogen content of the samples is measured using a commercially available analyzer." (NCT02850276)
Timeframe: week 8
| Intervention | Participants (Count of Participants) |
|---|---|
| Pyridostigmine | 13 |
Breath Test at week 8 as compared to baseline. Breath test results is the rise in the combined hydrogen and methane during the breath test. (NCT02850276)
Timeframe: baseline and week 8
| Intervention | ppm (Median) | |
|---|---|---|
| Baseline | week 8 | |
| Pyridostigmine | 28 | 14 |
Change in IL-6 plasma level at week 8 as compared to baseline. Plasma interleukin-6 (IL-6), an important inflammatory mediator which predicts mortality in HIV as well as multiple medical co-morbidities, presumably via inflammatory mechanisms. (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | mean florescence intensity (Median) | |
|---|---|---|
| Baseline | Week 8 | |
| Pyridostigmine | 30.5 | 26.5 |
Change in sCD14 level at week 8 as compared to baseline. sCD14 is a marker of macrophage activation commonly used as an indirect measure of translocation (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | mean florescence intensity (Median) | |
|---|---|---|
| Baseline | Week 8 | |
| Pyridostigmine | 2573 | 2095 |
TNFα is a pro-inflammatory cytokine which is induced by components of translocating bacteria. Change in TNFα level at week 8 compared to baseline (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | mean florescence intensity (Median) | |
|---|---|---|
| Baseline | week 8 | |
| Pyridostigmine | 134.0 | 117.5 |
Percent retention of gastric contents on gastric emptying study. GI dysmotility calculated from gastric emptying scintigraphy - measurement of the percent retention of gastric contents at 4 hours. (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | percent retention of gastric contents (Mean) | |
|---|---|---|
| Baseline | week 8 | |
| Pyridostigmine | 3 | 2 |
Medical Outcomes Study (MOS-HIV) quality of life questionnaire. It is a 35 item questionnaire covering 11 dimensions of health including physical functioning, role functioning, pain, social functioning, emotional well-being, energy/fatigue, cognitive functioning, general health, health distress, overall QOL, and health transition. The total scale ranges from 0-100 with a higher score representing better functioning and well-being. (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Week 8 | |
| Pyridostigmine | 66.1 | 65 |
The gastrointestinal domain domain score of the COMPASS contains 12 items which reflect gastrointestinal symptoms of autonomic function. It is scored on a total scale of 0-28, with higher numbers reflecting worse symptoms. (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Week 8 | |
| Pyridostigmine | 8 | 8.6 |
3 other studies available for hydrogen and Gastric Stasis
| Article | Year |
|---|---|
Small intestinal bacterial overgrowth in gastroparesis: are there any predictors?
Topics: Abdominal Pain; Adult; Breath Tests; Cohort Studies; Female; Gastric Emptying; Gastroparesis; Glucos | 2010 |
Small intestinal bacterial overgrowth in gastroparesis.
Topics: Adult; Biomarkers; Breath Tests; Female; Gastroparesis; Humans; Hydrogen; Intestine, Small; Lactulos | 2014 |
Breath hydrogen testing identifies patients with diabetic gastroparesis.
Topics: Biomarkers; Blood Glucose; Breath Tests; Chromatography, Gas; Diabetes Complications; Diabetes Melli | 2000 |