Page last updated: 2024-10-18

hydrogen and Diarrhea

hydrogen has been researched along with Diarrhea in 100 studies

Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"Dietary fructans exacerbate symptoms in some, but not all, adults with irritable bowel syndrome (IBS)."9.27Fructans Exacerbate Symptoms in a Subset of Children With Irritable Bowel Syndrome. ( Ali, A; Chumpitazi, BP; Elsaadi, A; McMeans, AR; Orlando, S; Shulman, RJ; Vaughan, A, 2018)
"Irritable bowel syndrome patients with diarrhea (IBS-D) and healthy volunteers (HVs) were enrolled and received a 10 g, 20 g, or 40 g dose lactose hydrogen breath test (LHBT) in a randomized, double-blinded, controlled trial."9.20Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea. ( Chu, H; Dai, N; Fox, M; Fried, M; Long, YQ; Pohl, D; Yang, JF; Zheng, X, 2015)
"People who identify themselves as severely lactose-intolerant may mistakenly attribute a variety of abdominal symptoms to lactose intolerance."9.08A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. ( Levitt, MD; Savaiano, DA; Suarez, FL, 1995)
"We investigated the effect of adding psyllium to a standard electrolyte solution in 10 calves with diarrhea."9.08Effect of psyllium on plasma concentration of glucose, breath hydrogen concentration, and fecal composition in calves with diarrhea treated orally with electrolyte solutions. ( Liebel, T; Naylor, JM, 1995)
"Using hydrogen breath testing (HBT) to diagnose small intestinal bacterial overgrowth (SIBO) remains controversial in patients with functional gastrointestinal (GI) disorders, and unknown in those with hypermobility Ehlers-Danlos syndrome (hEDS)."8.31Low prevalence of positive hydrogen breath tests in patients with functional gastrointestinal conditions and hypermobile Ehlers-Danlos syndrome. ( Brugaletta, C; Dervin, H; Emmanuel, A; Fragkos, K; Mensah, A; Raeburn, A; Sweis, R; Zarate-Lopez, N, 2023)
"Symptoms associated with lactose intolerance (LI) and diarrhea-predominant irritable bowel syndrome (IBS-D) are almost the same."7.85Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China. ( Chen, M; Gong, X; Wang, Y; Xiong, L, 2017)
"Lactose-free milk (LFM) is available for nutrient supply for those with lactose intolerance (LI)."7.83[Efficacy of Lactose-free Milk in Korean Adults with Lactose Intolerance]. ( Chang, YW; Chung, JY; Jang, JY; Kim, JW; Kim, SJ; Lee, MH; Nam, JH; Oh, CH; Park, SH; Yang, JO; Yoo, JA, 2016)
"Diarrhea-predominant irritable bowel syndrome patients with abnormal lactose HBTs ingested a test meal containing (99m) Tc and lactose."7.81Small intestinal bacterial overgrowth as an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhea-predominant irritable bowel syndrome in Asia. ( Chen, M; Gong, X; Li, W; Wang, Y; Xiong, L; Zhang, X, 2015)
"Methane excretion is clearly associated with alterations in intestinal motility, particularly favouring those with constipation."7.78Reassessment of the role of methane production between irritable bowel syndrome and functional constipation. ( Bruzzone, L; Dulbecco, P; Furnari, M; Gemignani, L; Giannini, EG; Moscatelli, A; Savarino, E; Savarino, V; Zentilin, P, 2012)
" The first, the maximum permissive dosage of lactose not to induce transitory diarrhea was estimated based on the oral ingestion of lactose at several dose levels in all the subjects, and compared with that of lactitol which is not hydrolyzed by digestive enzymes."7.73Maximum permissive dosage of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults. ( Ichinose, M; Nakamura, S; Oku, T, 2005)
"Abdominal pain and diarrhea are frequent side effects of chronic colchicine therapy."7.69Colchicine-induced lactose malabsorption in patients with familial Mediterranean fever. ( Fradkin, A; Jonas, A; Yahav, J; Zemer, D, 1995)
"Unsuspected bacterial contamination of the small intestine was indicated by breath hydrogen testing in nine patients aged 2 to 34 months during physical examinations for chronic diarrhea and abdominal pain."7.67Bacterial contamination of the small intestine as an important cause of chronic diarrhea and abdominal pain: diagnosis by breath hydrogen test. ( Davidson, GP; Kirubakaran, CP; Robb, TA, 1984)
"Breath hydrogen tests were carried out on 157 children either because they had chronic diarrhea or because they were on disaccharide-free diets."7.67Value of breath hydrogen analysis in management of diarrheal illness in childhood: comparison with duodenal biopsy. ( Davidson, GP; Robb, TA, 1985)
"Dietary fructans exacerbate symptoms in some, but not all, adults with irritable bowel syndrome (IBS)."5.27Fructans Exacerbate Symptoms in a Subset of Children With Irritable Bowel Syndrome. ( Ali, A; Chumpitazi, BP; Elsaadi, A; McMeans, AR; Orlando, S; Shulman, RJ; Vaughan, A, 2018)
"Irritable bowel syndrome patients with diarrhea (IBS-D) and healthy volunteers (HVs) were enrolled and received a 10 g, 20 g, or 40 g dose lactose hydrogen breath test (LHBT) in a randomized, double-blinded, controlled trial."5.20Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea. ( Chu, H; Dai, N; Fox, M; Fried, M; Long, YQ; Pohl, D; Yang, JF; Zheng, X, 2015)
"In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group."5.19Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO)--a pilot study. ( Behdani, R; Esmaeelzadeh, S; Jamali, J; Khalighi, AR; Khalighi, MR; Khalighi, N; Khosravi, A; Kouhestani, Sh; Radmanesh, H, 2014)
"Ten patients with bacterial overgrowth-related diarrhea underwent the following five 7-day treatment periods: untreated (control period), then placebo, and subsequently, in random order and blinded fashion, norfloxacin (800 mg/day), amoxicillin-clavulanic acid (1500 mg/day), and Saccharomyces boulardii (1500 mg/day)."5.09Antibiotic efficacy in small intestinal bacterial overgrowth-related chronic diarrhea: a crossover, randomized trial. ( Attar, A; Bouhnik, Y; Flourié, B; Franchisseur, C; Rambaud, JC; Ruszniewski, P, 1999)
"The purpose of this study was to determine if sacrosidase, a liquid produced from Saccharomyces cerevisiae containing 6000 IU of sucrase activity per mg protein, prevented symptoms of diarrhea, abdominal cramps, gas, and bloating in patients with congenital sucrase-isomaltase deficiency (CSID) consuming a normal sucrose and carbohydrate-containing diet."5.09Sacrosidase therapy for congenital sucrase-isomaltase deficiency. ( Hyams, J; Justinich, C; Kastoff, G; McAdams, L; Stanford, L; Treem, WR, 1999)
"People who identify themselves as severely lactose-intolerant may mistakenly attribute a variety of abdominal symptoms to lactose intolerance."5.08A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. ( Levitt, MD; Savaiano, DA; Suarez, FL, 1995)
"We investigated the effect of adding psyllium to a standard electrolyte solution in 10 calves with diarrhea."5.08Effect of psyllium on plasma concentration of glucose, breath hydrogen concentration, and fecal composition in calves with diarrhea treated orally with electrolyte solutions. ( Liebel, T; Naylor, JM, 1995)
"Using hydrogen breath testing (HBT) to diagnose small intestinal bacterial overgrowth (SIBO) remains controversial in patients with functional gastrointestinal (GI) disorders, and unknown in those with hypermobility Ehlers-Danlos syndrome (hEDS)."4.31Low prevalence of positive hydrogen breath tests in patients with functional gastrointestinal conditions and hypermobile Ehlers-Danlos syndrome. ( Brugaletta, C; Dervin, H; Emmanuel, A; Fragkos, K; Mensah, A; Raeburn, A; Sweis, R; Zarate-Lopez, N, 2023)
"Symptoms associated with lactose intolerance (LI) and diarrhea-predominant irritable bowel syndrome (IBS-D) are almost the same."3.85Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China. ( Chen, M; Gong, X; Wang, Y; Xiong, L, 2017)
"Lactose-free milk (LFM) is available for nutrient supply for those with lactose intolerance (LI)."3.83[Efficacy of Lactose-free Milk in Korean Adults with Lactose Intolerance]. ( Chang, YW; Chung, JY; Jang, JY; Kim, JW; Kim, SJ; Lee, MH; Nam, JH; Oh, CH; Park, SH; Yang, JO; Yoo, JA, 2016)
"Lactulose breath test graphs of 561 patients of all irritable bowel syndrome subtypes were grouped into categories based on their hydrogen + methane levels with respect to time."3.83Predicting a Response to Antibiotics in Patients with the Irritable Bowel Syndrome. ( Adler, M; Dhingra, S; Guttermuth, C; Kasir, R; Lee, A; Zakko, P; Zakko, S, 2016)
"Diarrhea-predominant irritable bowel syndrome patients with abnormal lactose HBTs ingested a test meal containing (99m) Tc and lactose."3.81Small intestinal bacterial overgrowth as an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhea-predominant irritable bowel syndrome in Asia. ( Chen, M; Gong, X; Li, W; Wang, Y; Xiong, L; Zhang, X, 2015)
"Methane excretion is clearly associated with alterations in intestinal motility, particularly favouring those with constipation."3.78Reassessment of the role of methane production between irritable bowel syndrome and functional constipation. ( Bruzzone, L; Dulbecco, P; Furnari, M; Gemignani, L; Giannini, EG; Moscatelli, A; Savarino, E; Savarino, V; Zentilin, P, 2012)
"Fructose absorption was measured using 3-hour breath hydrogen tests and symptom scores were used to rate subjective responses for gas, borborygmus, abdominal pain, and loose stools."3.73Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults. ( Beyer, PL; Caviar, EM; McCallum, RW, 2005)
" The first, the maximum permissive dosage of lactose not to induce transitory diarrhea was estimated based on the oral ingestion of lactose at several dose levels in all the subjects, and compared with that of lactitol which is not hydrolyzed by digestive enzymes."3.73Maximum permissive dosage of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults. ( Ichinose, M; Nakamura, S; Oku, T, 2005)
"We have previously shown that methane on lactulose breath test (LBT) is highly associated with constipation in IBS and that methane gas itself slows small bowel transit in dogs."3.72IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen. ( Kong, Y; Park, S; Pimentel, M, 2004)
"Abdominal pain and diarrhea are frequent side effects of chronic colchicine therapy."3.69Colchicine-induced lactose malabsorption in patients with familial Mediterranean fever. ( Fradkin, A; Jonas, A; Yahav, J; Zemer, D, 1995)
"To reevaluate the timing and level of rise in breath hydrogen (H2) excretion following oral lactose challenge in children with respect to the subsequent development of symptoms consistent with lactose intolerance."3.69Delta 10 ppm versus delta 20 ppm: a reappraisal of diagnostic criteria for breath hydrogen testing in children. ( Burke, G; Hyams, JS; Sullivan, B; Treem, WR; Veligati, LN, 1994)
"Twenty-five patients with chronic diarrhea were studied with a combined glucose-hydrogen breath test (GHBT) and nuclear transit scan to elucidate the role of abnormal transit in the pathogenesis of diarrhea."3.68Glucose malabsorption associated with rapid intestinal transit. ( Hart, R; Sellin, JH, 1992)
" We found a strong association between lactose intolerance and persistent diarrheal disease in this population (p less than 0."3.68Gastrointestinal dysfunction and disaccharide intolerance in children infected with human immunodeficiency virus. ( Greenson, J; Hart, W; Oung, I; Perman, JA; Shiff, C; Yolken, RH, 1991)
"Unsuspected bacterial contamination of the small intestine was indicated by breath hydrogen testing in nine patients aged 2 to 34 months during physical examinations for chronic diarrhea and abdominal pain."3.67Bacterial contamination of the small intestine as an important cause of chronic diarrhea and abdominal pain: diagnosis by breath hydrogen test. ( Davidson, GP; Kirubakaran, CP; Robb, TA, 1984)
"A 13CO2 breath test using naturally enriched 13C-lactose as a substrate was performed in 47 patients with chronic abdominal pain or chronic diarrhea, taken from a population with a low prevalence of primary acquired lactase deficiency."3.6713CO2 breath test using naturally 13C-enriched lactose for detection of lactase deficiency in patients with gastrointestinal symptoms. ( Carchon, H; Eggermont, E; Ghoos, Y; Hiele, M; Rutgeerts, P; Vantrappen, G, 1988)
"Breath hydrogen tests were carried out on 157 children either because they had chronic diarrhea or because they were on disaccharide-free diets."3.67Value of breath hydrogen analysis in management of diarrheal illness in childhood: comparison with duodenal biopsy. ( Davidson, GP; Robb, TA, 1985)
"To evaluate the role of the lactose breath hydrogen test for the detection of lactose malabsorption in children with chronic nonspecific abdominal complaints, breath hydrogen excretion was measured in 131 children with recurrent abdominal pain (n = 75) or chronic nonspecific diarrhea (n = 56) following a lactose load (2 gm/kg; maximum 50 gm)."3.66Mucosal function and breath hydrogen excretion: comparative studies in the clinical evaluation of children with nonspecific abdominal complaints. ( Barr, RG; Perman, JA; Watkins, JB, 1981)
"An oral sucrose tolerance test was performed in a group of 103 children, aged between 3 months and 15 years because of episodic diarrhea and/or abdominal pains."3.66Diagnostic value of sucrose tolerance test in children evaluated by breath hydrogen measurement. ( Douwes, AC; Fernandes, J; Jongbloed, AA, 1980)
"The relation between small intestinal transit time and postgastrectomy diarrhea was investigated with a technique which employs the measurement of pulmonary H2 excretion after ingestion of the nonabsorbable sugar, lactulose."3.65Use of breath hydrogen (H2) to quantitate small bowel transit time following partial gastrectomy. ( Bond, JH; Levitt, MD, 1977)
"Lactose intolerance is caused by lactase enzyme deficiency in the small bowel mucosa leading to lactose malabsorption and symptoms of bloating, gas, and diarrhea."2.82Bacterial overgrowth and lactose intolerance: how to best assess. ( Ghafoor, A; Karunaratne, T; Rao, SSC, 2022)
"Symptoms of bloating and abdominal cramps attributable to gaseousness were also significantly reduced in both groups by activated charcoal."2.66Efficacy of activated charcoal in reducing intestinal gas: a double-blind clinical trial. ( Jain, NK; Patel, VP; Pitchumoni, CS, 1986)
"Lactose malabsorption was present in 27/31 (87%) patients with CFD and 29/32 (91%) healthy controls (P = 0."1.36Lactose intolerance in patients with chronic functional diarrhoea: the role of small intestinal bacterial overgrowth. ( Chu, H; Cong, Y; Dai, N; Fox, M; Fried, M; Shang, Y; Zhao, J, 2010)
"Hydrogen breath test was normal in all of them, none developed abdominal discomfort."1.28[Fructose malabsorption and dysfunctional gastrointestinal manifestations]. ( Götze, H; Mahdi, A, 1992)
"Lactose malabsorption was estimated by integrating the area under the excess H2 curve."1.27Small intestine transit time and lactose absorption during phototherapy. ( Dinari, G; Goodman, C; Merlob, P; Nitzan, M; Sivan, Y, 1985)
"of lactose."1.25Breath hydrogen as a diagnostic method for hypolactasia. ( Blendis, LM; Jenkins, DJ; Metz, G; Newman, A; Peters, TJ, 1975)

Research

Studies (100)

TimeframeStudies, this research(%)All Research%
pre-199033 (33.00)18.7374
1990's32 (32.00)18.2507
2000's11 (11.00)29.6817
2010's15 (15.00)24.3611
2020's9 (9.00)2.80

Authors

AuthorsStudies
Nalyotov, AV1
Svistunova, NA1
Ghafoor, A1
Karunaratne, T1
Rao, SSC1
Muratore, A1
Shah, ED1
Chan, WW1
Sikander, A1
Rana, SV1
Sinha, SK1
Prasad, KK1
Arora, SK1
Bustos Fernández, LM1
Man, F1
Lasa, JS1
Tansel, A1
Levinthal, DJ1
Dervin, H1
Zarate-Lopez, N1
Sweis, R1
Mensah, A1
Fragkos, K1
Brugaletta, C1
Raeburn, A1
Emmanuel, A1
Rezaie, A1
Ortiz-Barrios, M1
Gul, M1
López-Meza, P1
Yucesan, M1
Navarro-Jiménez, E1
Khuntia, HK1
Chanakya, HN1
D'Arienzo, M1
Coniglio, A1
Boag, AM1
Short, A1
Kennedy, LJ1
Syme, H1
Graham, PA1
Catchpole, B1
Tofighi, B1
El Shahawy, O1
Segoshi, A1
Moreno, KP1
Badiei, B1
Sarker, A1
Krawczyk, N1
Zhou, Y1
Li, R1
Guo, B1
Zhang, L1
Zhang, H1
Xia, S1
Liu, Y1
Nielsen, CU1
Pedersen, M1
Müller, S1
Kæstel, T1
Bjerg, M1
Ulaganathan, N1
Nielsen, S1
Carlsen, KL1
Nøhr, MK1
Holm, R1
Dottino, JA1
Zhang, Q2
Loose, DS1
Fellman, B1
Melendez, BD1
Borthwick, MS1
McKenzie, LJ1
Yuan, Y1
Yang, RK1
Broaddus, RR1
Lu, KH1
Soliman, PT1
Yates, MS1
Zhu, Z1
Hasegawa, K1
Ma, B1
Fujiogi, M1
Camargo, CA1
Liang, L1
Sangroula, S1
Baez Vasquez, AY1
Raut, P1
Obeng, B1
Shim, JK1
Bagley, GD1
West, BE1
Burnell, JE1
Kinney, MS1
Potts, CM1
Weller, SR1
Kelley, JB1
Hess, ST1
Gosse, JA1
Breves, JP1
Springer-Miller, RH1
Chenoweth, DA1
Paskavitz, AL1
Chang, AYH1
Regish, AM1
Einarsdottir, IE1
Björnsson, BT1
McCormick, SD1
Villmones, HC1
Halland, A1
Stenstad, T1
Ulvestad, E1
Weedon-Fekjær, H1
Kommedal, Ø1
Nasri, A1
Jaleh, B1
Khazalpour, S1
Nasrollahzadeh, M1
Shokouhimehr, M1
Ferrario, M1
Fenoglio, D1
Chantada, A1
Guerrero, S1
Odetayo, AA1
Reible, DD1
Acevedo-Mackey, D1
Price, C1
Thai, L1
Li, S1
Lin, Y1
Wang, D1
Zhang, C1
Wang, Z1
Li, X1
Chen, Y2
Nie, E1
Huang, L1
Lu, Y1
Gao, X1
Akhtar, K1
Ye, Q1
Wang, H1
Yang, Y2
Li, Y1
Wang, M1
Chen, W1
Dai, Y2
Guo, X1
An, Y1
Chai, C1
Sang, J1
Jiang, L1
Lu, F1
Liu, F1
Pu, Y1
Zhou, B1
Xiang, H1
Wu, W1
Yin, H1
Yue, W1
Yin, Y1
Li, H1
Xu, H1
Shaw, L1
Shaw, D1
Hardisty, M1
Britz-McKibbin, P1
Verma, DK1
Li, W2
Wufuer, R1
Duo, J1
Wang, S1
Luo, Y1
Zhang, D1
Pan, X1
Jones, DL1
Baluja, MQ1
Graham, DW1
Corbishley, A1
McDonald, JE1
Malham, SK1
Hillary, LS1
Connor, TR1
Gaze, WH1
Moura, IB1
Wilcox, MH1
Farkas, K1
Liu, X1
Wang, J2
Shao, X1
Liu, J1
Ji, X1
Tian, G1
Zhang, Y1
Sun, R1
Wang, L1
Zhu, Y1
Tuyiringire, D1
Li, K1
Han, W1
Wang, Y3
Yan, L1
El Hayany, B1
El Fels, L1
Quénéa, K1
Dignac, MF1
Rumpel, C1
Gupta, VK1
Hafidi, M1
de Oliveira, BR1
Bragança, MLBM1
Batalha, MA1
Coelho, CCNDS1
Bettiol, H1
Barbieri, MA1
Saraiva, MDCP1
Kac, G1
da Silva, AAM1
Rather, BA1
Mir, IR1
Sehar, Z1
Anjum, NA1
Masood, A1
Khan, NA1
Songsamoe, S1
Koomhin, P1
Matan, N1
Flögel, F1
Gärtner, S1
Rahimi Khonakdari, M1
Rezadoost, H1
Heydari, R1
Mirjalili, MH1
Kebaili, I1
Boukhris, I1
Sayyed, MI1
Tonguc, B1
Al-Buriahi, MS1
Ganson, KT1
Nagata, JM1
Cole, MA2
Ozgen, C1
Strobl, E1
Coker, ES1
Cavalli, L1
Fabrizi, E1
Guastella, G1
Lippo, E1
Parisi, ML1
Pontarollo, N1
Rizzati, M1
Varacca, A1
Vergalli, S1
Elliott, RJR1
Liu, B1
Bajelan, S1
Bahreini, MS1
Asgari, Q1
Mikaeili, F1
Lakmal, MAC1
Ekanayake, EMDNK1
Kelum, SHP1
Gamage, BD1
Jayasundara, JASB1
Gautam, S1
Gautam, A1
Chhetri, S1
Bhattarai, U1
Acharjee, N1
Patel, AK1
Lodha, D1
Shekhawat, NS1
Zeng, W1
Dong, A1
Chen, X1
Cheng, ZL1
Campo, M1
Amandi, A1
Biset, JC1
Roviello, V1
Roviello, GN1
Chumpitazi, BP1
McMeans, AR1
Vaughan, A1
Ali, A1
Orlando, S1
Elsaadi, A1
Shulman, RJ1
Xiong, L2
Gong, X2
Chen, M2
Ghoshal, UC1
Srivastava, D1
Ghoshal, U1
Misra, A1
Łokieć, K1
Klupińska, G1
Walecka-Kapica, E1
Błońska, A1
Zhang, X1
Khalighi, AR1
Khalighi, MR1
Behdani, R1
Jamali, J1
Khosravi, A1
Kouhestani, Sh1
Radmanesh, H1
Esmaeelzadeh, S1
Khalighi, N1
Yang, JF1
Fox, M2
Chu, H2
Zheng, X1
Long, YQ1
Pohl, D1
Fried, M2
Dai, N2
Kasir, R1
Zakko, S1
Zakko, P1
Adler, M1
Lee, A1
Dhingra, S1
Guttermuth, C1
Park, SH1
Chang, YW1
Kim, SJ1
Lee, MH1
Nam, JH1
Oh, CH1
Kim, JW1
Jang, JY1
Yang, JO1
Yoo, JA1
Chung, JY1
Major, G1
Pritchard, S1
Murray, K1
Alappadan, JP1
Hoad, CL1
Marciani, L1
Gowland, P1
Spiller, R1
Casellas, F1
Varela, E1
Aparici, A1
Casaus, M1
Rodríguez, P1
Mancilla A, C1
Madrid S, AM1
Hurtado H, C1
Orellana B, C1
Peña Z, M1
Tobar A, E1
Berger F, Z1
Zhao, J1
Cong, Y1
Shang, Y1
Schommer, K1
Reljic, D1
Bärtsch, P1
Sauer, P1
Frieling, T1
Kuhlbusch-Zicklam, R1
Kalde, S1
Heise, J1
Hülsdonk, A1
Kreysel, C1
Furnari, M1
Savarino, E1
Bruzzone, L1
Moscatelli, A1
Gemignani, L1
Giannini, EG1
Zentilin, P1
Dulbecco, P1
Savarino, V1
Hammer, HF1
Hammer, J1
Visser, G1
Rake, JP1
Kokke, FT1
Nikkels, PG1
Sauer, PJ1
Smit, GP1
Vonk, RJ1
Priebe, MG1
Koetse, HA1
Stellaard, F1
Lenoir-Wijnkoop, I1
Antoine, JM1
Zhong, Y1
Huang, CY1
Pimentel, M1
Kong, Y1
Park, S1
Oku, T1
Nakamura, S1
Ichinose, M1
Beyer, PL1
Caviar, EM1
McCallum, RW1
Chekhonina, IuG1
Davidson, GP3
Robb, TA3
Kirubakaran, CP1
Perman, JA3
Modler, S1
Barr, RG2
Rosenthal, P1
Barnes, G1
McKellar, W1
Lawrance, S1
Welsh, JD1
Griffiths, WJ1
Saunders, DR1
Sillery, J1
Ruppin, H1
Domschke, W1
Watkins, JB1
Douwes, AC1
Fernandes, J1
Jongbloed, AA1
Isselbacher, KJ1
Ladas, SD1
Haritos, DN1
Raptis, SA1
Hoekstra, JH3
van den Aker, JH1
Ghoos, YF1
Hartemink, R1
Kneepkens, CM3
Carlson, S1
Craig, RM1
Briet, F1
Achour, L1
Flourié, B3
Beaugerie, L1
Pellier, P1
Franchisseur, C2
Bornet, F2
Rambaud, JC2
Fradkin, A1
Yahav, J1
Zemer, D1
Jonas, A1
Naylor, JM1
Liebel, T1
Suarez, FL1
Savaiano, DA1
Levitt, MD3
Smith, MM1
Davis, M1
Chasalow, FI1
Lifshitz, F1
Soergel, KH1
Lifschitz, CH1
Carrazza, FR1
Feste, AS1
Klein, PD1
Tajiri, H1
Hamamoto, T1
Harada, T1
Okada, S1
Veligati, LN1
Treem, WR2
Sullivan, B1
Burke, G1
Hyams, JS2
Turberg, Y1
Dederding, JP1
van Kempen, AA1
Bijl, SB1
Hermans, MM1
Brummer, RJ1
Ruijgers, AM1
Stockbrügger, RW1
McAdams, L1
Stanford, L1
Kastoff, G1
Justinich, C1
Hyams, J1
Attar, A1
Ruszniewski, P1
Bouhnik, Y1
Riordan, SM1
McIver, CJ1
Duncombe, VM2
Thomas, MC1
Bolin, TD2
Gutzwiller, A1
Lin, HC1
van Citters, GW1
Heimer, F1
Bonorris, G1
Hallfrisch, J1
Behall, KM1
Metz, G2
Jenkins, DJ1
Peters, TJ1
Newman, A1
Blendis, LM1
Cook, GC1
Bond, JH2
Maffei, HV1
Bampoe, V1
Shiner, M1
Herman, S1
Brook, CG1
Götze, H1
Mahdi, A1
Sanders, SW1
Tolman, KG1
Reitberg, DP1
Sellin, JH1
Hart, R1
Cloarec, D1
Gouilloud, S1
Bruley des Varannes, S1
Bizais, Y1
Galmiche, JP1
Pereira, SP1
Linklater, JM1
Kemen, M1
Homann, HH1
von Liebe, S1
Zumtobel, V1
Loginov, AS1
Lorie, NIu1
Petrakov, AV1
Parfenov, AI1
Bendikov, EA1
Poleva, NI1
Daletskaia, GV1
Yolken, RH1
Hart, W1
Oung, I1
Shiff, C1
Greenson, J1
Wegener, M1
Schaffstein, J1
Dilger, U1
Coenen, C1
Wedmann, B1
Schmidt, G1
Classen, M1
Medow, MS1
Thek, KD1
Newman, LJ1
Berezin, S1
Glassman, MS1
Schwarz, SM1
Hassan, NA1
al-Ani, MR1
Lafta, AM1
Kassir, ZA1
Badiga, MS1
Jain, NK3
Casanova, C1
Pitchumoni, CS3
Boivin, M1
Rizza, RA1
Go, VL1
DiMagno, EP1
Booth, IW1
Stange, G1
Murer, H1
Fenton, TR1
Milla, PJ1
Littman, A1
Hiele, M1
Ghoos, Y1
Rutgeerts, P1
Vantrappen, G1
Carchon, H1
Eggermont, E1
Patel, VP1
Siegenbeek van Heukelom, J1
Stephensen, CB1
Sack, RB1
Sack, DA1
Washabau, RJ1
Strombeck, DR1
Buffington, CA1
Harrold, D1
Rao, SS1
Read, NW1
Holdsworth, CD1
Keshavarzian, A1
Iber, FL1
Dangleis, MD1
Cornish, R1
Holmberg, C1
Perheentupa, J1
Hayashi, JT1
Wolfe, BM1
Calvert, CC1
Leichtner, AM1
Rosenberg, DB1
Ulahannan, MJ1
Glasser, MJ1
Sivan, Y1
Dinari, G1
Goodman, C1
Merlob, P1
Nitzan, M1
Forgacs, P1
Wright, PH1
Wyatt, AP1
Seldin, DW1
Rector, FC1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intestinal Microbiome Fructan Metabolism and Symptom Generation in Childhood IBS[NCT02842281]55 participants (Actual)Interventional2014-09-30Completed
The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population[NCT01286597]3,000 participants (Anticipated)Interventional2011-01-31Recruiting
Crossover Trial of Gluten and Gluten With Amylase-trypsin Inhibitors as Triggers of Gastrointestinal Symptoms in Patients With Irritable Bowel Syndrome[NCT03664531]34 participants (Anticipated)Interventional2019-01-01Recruiting
Effects of Fibre on Intestinal Volume and Gas in Irritable Bowel Syndrome[NCT03265002]19 participants (Actual)Interventional2018-03-08Completed
Fructose and Fructans and Irritable Bowel Syndrome: MRI Study of Underlying Mechanisms[NCT01776853]69 participants (Actual)Interventional2013-01-31Completed
Evaluation of the Efficacy and Safety of Single, Daily Oral Doses of SYN-010 Compared to Placebo in Adult Patients With Irritable Bowel Syndrome With Constipation (EASE-DO)[NCT03763175]Phase 259 participants (Actual)Interventional2018-12-24Terminated (stopped due to Interim Futility Analysis)
Colonic Microbial and Clinical Adaptation to Large Doses of Fructose[NCT00775567]45 participants (Actual)Interventional2008-01-31Completed
A Multicenter, Double-Blind, Placebo-Controlled Trial to Evaluate the Frequency of Genetic Sucrase-Isomaltase Deficiency Genotypes, and the Efficacy and Safety of Sucraid® (Sacrosidase) Oral Solution in Subjects With Chronic Diarrhea and Sucrase Deficienc[NCT02784067]Phase 40 participants (Actual)Interventional2016-05-31Withdrawn (stopped due to Clinical Trial Material)
Retrospective Analysis of Treatment Outcomes in Patients With Bacterial Overgrowth Syndrome Diagnosed by D-Xylose Breath Testing[NCT01324895]944 participants (Actual)Observational2010-08-31Completed
Gastrointestinal Motility Among Diabetes Patients[NCT02573519]40 participants (Actual)Interventional2015-10-31Terminated (stopped due to Renewal of PET/CT scanners and slow recruitment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Breath Methane Production Based on a Single-point Breath Methane Test

Change in exhaled methane level as a potential predictor of constipation improvement will be evaluated by comparing single-point breath tests pre- and post-treatment. (NCT03763175)
Timeframe: After completing course of SYN-010

Interventionparticles per million (Mean)
SYN-010 21 mg-22.623
SYN-010 42 mg-4.785
Placebo-10.081

Change From Baseline in the Weekly Average Number of Completely Spontaneous Bowel Movements (CSBM) Compared to the 12-week Treatment Period

Subjects will record their daily bowel movements throughout the duration of the study. Change in weekly average number of CSBMs will be evaluated by comparing reported values pre- and post-treatment. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionWeekly average CSBMs (Least Squares Mean)
SYN-010 21 mg1.53
SYN-010 42 mg0.32
Placebo0.51

Mean Change From Baseline in the Area-under-the-curve (AUC) of Breath Methane Production, Based on the 120-minute Lactulose Breath Test.

Change in exhaled methane level as a potential predictor of constipation improvement will be evaluated by comparing lactulose breath tests pre- and post-treatment. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

Interventionparticles per million * min (Mean)
SYN-010 21 mg-18.678
SYN-010 42 mg-20.137
Placebo-39.199

Proportion of Overall Abdominal Pain Intensity Responders During the 12-week Treatment Period

An overall abdominal pain intensity responder is defined as a patient with a weekly abdominal pain intensity response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly response abdominal pain intensity response is defined as a decrease in the patient's weekly average score for worst abdominal pain in the past 24 hours of at least 30% compared to baseline, with stool frequency unchanged or improved compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg4
SYN-010 42 mg4
Placebo7

Proportion of Overall Bloating Responders During the 12-week Treatment Period

An overall bloating responder is defined as a patient with a weekly bloating response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly bloating response is defined as a weekly average bloating score of at least 30% improvement compared to baseline, with stool frequency unchanged or improved compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg3
SYN-010 42 mg3
Placebo1

Proportion of Overall Responders During the 12-week Treatment Period

An overall 12-week responder is defined as a patient with a weekly response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly response is defined as a decrease in the patient's weekly average score for worst abdominal pain in the past 24 hours of at least 30% compared to baseline and a stool frequency increase of 1 or more CSBMs per week compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg1
SYN-010 42 mg2
Placebo6

Proportion of Overall Stool Frequency Responders During the 12-week Treatment Period

An overall stool frequency responder is defined as a patient with a weekly stool frequency response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly stool frequency response is defined as a stool frequency increase of 1 or more CSBMs per week compared with baseline, with abdominal pain unchanged or improved compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg4
SYN-010 42 mg6
Placebo9

Proportion of Patients Using Rescue Medication

Subjects will record their use of rescue medication throughout the study period. Proportion of patients using rescue medication after completing the 12-week course of treatment will be compared to those reporting usage at baseline screening period. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg9
SYN-010 42 mg11
Placebo8

Proportion of Patients With Adequate Relief

Outcome will be assessed by evaluating proportion of patients reporting adequate relief pre- and post-treatment on validated questionnaire. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg1
SYN-010 42 mg2
Placebo6

Reviews

6 reviews available for hydrogen and Diarrhea

ArticleYear
Bacterial overgrowth and lactose intolerance: how to best assess.
    Current opinion in clinical nutrition and metabolic care, 2022, 09-01, Volume: 25, Issue:5

    Topics: Breath Tests; Diarrhea; Humans; Hydrogen; Lactase; Lactose Intolerance; Methane

2022
Understanding Our Tests: Hydrogen-Methane Breath Testing to Diagnose Small Intestinal Bacterial Overgrowth.
    Clinical and translational gastroenterology, 2023, 04-01, Volume: 14, Issue:4

    Topics: Breath Tests; Diarrhea; Humans; Hydrogen; Intestine, Small; Methane

2023
    International journal of disaster risk reduction : IJDRR, 2020, Volume: 49

    Topics: Acyclic Monoterpenes; Adipose Tissue; Adolescent; Adult; Aged; Aged, 80 and over; Air Pollutants; Ai

2020
Diarrhea caused by carbohydrate malabsorption.
    Gastroenterology clinics of North America, 2012, Volume: 41, Issue:3

    Topics: Anti-Bacterial Agents; Bacteria; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Diarrhea; Die

2012
Physiological aspects of absorption and secretion in intestine.
    Veterinary research communications, 1986, Volume: 10, Issue:5

    Topics: Animals; Biological Transport, Active; Body Water; Diarrhea; Epithelium; Hydrogen; Intestinal Absorp

1986
Symposium on acid-base homeostasis. The generation and maintenance of metabolic alkalosis.
    Kidney international, 1972, Volume: 1, Issue:5

    Topics: Alkalosis; Ammonia; Animals; Bicarbonates; Diarrhea; Diet, Sodium-Restricted; Diuretics; Extracellul

1972

Trials

20 trials available for hydrogen and Diarrhea

ArticleYear
Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study.
    Digestive diseases (Basel, Switzerland), 2023, Volume: 41, Issue:5

    Topics: Diarrhea; Gastrointestinal Microbiome; Humans; Hydrogen; Intestine, Small; Irritable Bowel Syndrome;

2023
Fructans Exacerbate Symptoms in a Subset of Children With Irritable Bowel Syndrome.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2018, Volume: 16, Issue:2

    Topics: Adolescent; Breath Tests; Child; Cross-Over Studies; Diarrhea; Dietary Supplements; Double-Blind Met

2018
Breath tests in the diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome in comparison with quantitative upper gut aspirate culture.
    European journal of gastroenterology & hepatology, 2014, Volume: 26, Issue:7

    Topics: Adolescent; Adult; Aged; Blind Loop Syndrome; Breath Tests; Diarrhea; Female; Glucose; Humans; Hydro

2014
Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO)--a pilot study.
    The Indian journal of medical research, 2014, Volume: 140, Issue:5

    Topics: Abdominal Pain; Adult; Bacterial Infections; Breath Tests; Diarrhea; Double-Blind Method; Female; Hu

2014
Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea.
    World journal of gastroenterology, 2015, Jun-28, Volume: 21, Issue:24

    Topics: Biomarkers; Breath Tests; China; Cross-Over Studies; Diarrhea; Double-Blind Method; Genetic Predispo

2015
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid;

2017
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid;

2017
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid;

2017
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid;

2017
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid;

2017
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid;

2017
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid;

2017
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid;

2017
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Case-Control Studies; Colon; Colon, Sigmoid;

2017
Intestinal function in glycogen storage disease type I.
    Journal of inherited metabolic disease, 2002, Volume: 25, Issue:4

    Topics: Adolescent; Adult; alpha 1-Antitrypsin; Child; Child, Preschool; Chronic Disease; Chymotrypsin; Colo

2002
Honey may have a laxative effect on normal subjects because of incomplete fructose absorption.
    The American journal of clinical nutrition, 1995, Volume: 62, Issue:6

    Topics: Absorption; Administration, Oral; Adult; Analysis of Variance; Breath Tests; Cathartics; Diarrhea; D

1995
Fluid intake and industrial processing in apple juice induced chronic non-specific diarrhoea.
    Archives of disease in childhood, 1995, Volume: 73, Issue:2

    Topics: Breath Tests; Child Nutritional Physiological Phenomena; Child, Preschool; Chronic Disease; Cross-Ov

1995
Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly.
    European journal of clinical nutrition, 1995, Volume: 49, Issue:7

    Topics: Adult; Breath Tests; Cross-Over Studies; Diarrhea; Dietary Carbohydrates; Dose-Response Relationship

1995
Effect of psyllium on plasma concentration of glucose, breath hydrogen concentration, and fecal composition in calves with diarrhea treated orally with electrolyte solutions.
    American journal of veterinary research, 1995, Volume: 56, Issue:1

    Topics: Analysis of Variance; Animals; Blood Glucose; Breath Tests; Cattle; Cattle Diseases; Cross-Over Stud

1995
A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance.
    The New England journal of medicine, 1995, Jul-06, Volume: 333, Issue:1

    Topics: Abdominal Pain; Adolescent; Adult; Animals; Breath Tests; Cross-Over Studies; Diarrhea; Double-Blind

1995
Carbohydrate absorption from fruit juice in young children.
    Pediatrics, 1995, Volume: 95, Issue:3

    Topics: Beverages; Breath Tests; Cross-Over Studies; Diarrhea; Dietary Carbohydrates; Double-Blind Method; F

1995
Sacrosidase therapy for congenital sucrase-isomaltase deficiency.
    Journal of pediatric gastroenterology and nutrition, 1999, Volume: 28, Issue:2

    Topics: Animals; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Diarrhea; Do

1999
Antibiotic efficacy in small intestinal bacterial overgrowth-related chronic diarrhea: a crossover, randomized trial.
    Gastroenterology, 1999, Volume: 117, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria;

1999
Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans.
    Digestive diseases and sciences, 2001, Volume: 46, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Case-Control Studies; Chronic Disease; Def

2001
Breath hydrogen and methane responses of men and women to breads made with white flour or whole wheat flours of different particle sizes.
    Journal of the American College of Nutrition, 1999, Volume: 18, Issue:4

    Topics: Adult; Bread; Breath Tests; Diarrhea; Digestion; Female; Flatulence; Flour; Humans; Hydrogen; Male;

1999
Effect of a single dose of lactase on symptoms and expired hydrogen after lactose challenge in lactose-intolerant subjects.
    Clinical pharmacy, 1992, Volume: 11, Issue:6

    Topics: Abdominal Muscles; Adult; beta-Galactosidase; Blood Glucose; Breath Tests; Diarrhea; Double-Blind Me

1992
Beta-galactosidase tablets in the treatment of lactose intolerance in pediatrics.
    American journal of diseases of children (1960), 1990, Volume: 144, Issue:11

    Topics: Abdominal Pain; Adolescent; beta-Galactosidase; Breath Tests; Child; Diarrhea; Double-Blind Method;

1990
Efficacy of activated charcoal in reducing intestinal gas: a double-blind clinical trial.
    The American journal of gastroenterology, 1986, Volume: 81, Issue:7

    Topics: Breath Tests; Charcoal; Clinical Trials as Topic; Colic; Diarrhea; Double-Blind Method; Female; Gase

1986

Other Studies

74 other studies available for hydrogen and Diarrhea

ArticleYear
[Assessment of the state of the small intestine microbiota in children on a long-term dairy-free diet].
    Voprosy pitaniia, 2022, Volume: 91, Issue:2

    Topics: Abdominal Pain; Blind Loop Syndrome; Child; Constipation; Diarrhea; Diet; Humans; Hydrogen; Intestin

2022
Cost-Benefit Analysis of Hydrogen Breath Test-Directed Rifaximin for Treatment of Diarrhea-Predominant Irritable Bowel Syndrome.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2023, Volume: 21, Issue:10

    Topics: Breath Tests; Cost-Benefit Analysis; Diarrhea; Humans; Hydrogen; Irritable Bowel Syndrome; Rifamycin

2023
Association of serotonin transporter promoter polymorphism (5-HTTLPR) with orocecal transit time in irritable bowel syndrome.
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2022, Volume: 41, Issue:6

    Topics: Case-Control Studies; Constipation; Diarrhea; Humans; Hydrogen; Irritable Bowel Syndrome; Lactulose;

2022
Low prevalence of positive hydrogen breath tests in patients with functional gastrointestinal conditions and hypermobile Ehlers-Danlos syndrome.
    Neurogastroenterology and motility, 2023, Volume: 35, Issue:9

    Topics: Adult; Breath Tests; Diarrhea; Ehlers-Danlos Syndrome; Female; Gastrointestinal Diseases; Humans; Hy

2023
Shedding Light on Elevated Baseline Hydrogen and Flat-Line Patterns During Breath Testing.
    The American journal of gastroenterology, 2020, Volume: 115, Issue:6

    Topics: Breath Tests; Diarrhea; Humans; Hydrogen; Irritable Bowel Syndrome; Lactulose; Rifaximin

2020
Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China.
    Journal of health, population, and nutrition, 2017, Nov-21, Volume: 36, Issue:1

    Topics: Adult; Animals; Breath Tests; China; Diarrhea; Female; Humans; Hydrogen; Irritable Bowel Syndrome; L

2017
[Estimation of small intestinal bacterial overgrowth in patients with constipation and diarrhea irritable bowel syndrome].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2014, Volume: 36, Issue:215

    Topics: Adolescent; Adult; Blind Loop Syndrome; Breath Tests; Causality; Comorbidity; Constipation; Diarrhea

2014
Small intestinal bacterial overgrowth as an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhea-predominant irritable bowel syndrome in Asia.
    Journal of gastroenterology and hepatology, 2015, Volume: 30, Issue:6

    Topics: Adult; Asia; Breath Tests; Diarrhea; False Positive Reactions; Female; Gastrointestinal Transit; Hum

2015
Predicting a Response to Antibiotics in Patients with the Irritable Bowel Syndrome.
    Digestive diseases and sciences, 2016, Volume: 61, Issue:3

    Topics: Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Breath Tests; Constipation; Diarrhea; Fema

2016
[Efficacy of Lactose-free Milk in Korean Adults with Lactose Intolerance].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2016, Jan-25, Volume: 67, Issue:1

    Topics: Abdominal Pain; Adult; Aged; Animals; Asian People; Breath Tests; Diarrhea; Female; Humans; Hydrogen

2016
Development, validation, and applicability of a symptoms questionnaire for lactose malabsorption screening.
    Digestive diseases and sciences, 2009, Volume: 54, Issue:5

    Topics: Abdominal Pain; Adult; Breath Tests; Diarrhea; Female; Flatulence; Humans; Hydrogen; Lactose Intoler

2009
[Small intestine bacterial overgrowth in patients with chronic pancreatitis].
    Revista medica de Chile, 2008, Volume: 136, Issue:8

    Topics: Adult; Aged; Bacteria; Bacterial Infections; Breath Tests; Case-Control Studies; Chile; Diarrhea; Di

2008
Lactose intolerance in patients with chronic functional diarrhoea: the role of small intestinal bacterial overgrowth.
    Alimentary pharmacology & therapeutics, 2010, Volume: 31, Issue:8

    Topics: Adult; Bacterial Infections; Breath Tests; Diarrhea; Female; Humans; Hydrogen; Intestine, Small; Irr

2010
Gastrointestinal complaints in runners are not due to small intestinal bacterial overgrowth.
    Journal of negative results in biomedicine, 2011, Jul-27, Volume: 10, Issue:1

    Topics: Adult; Bacterial Infections; Breath Tests; Diarrhea; Female; Flatulence; Gastrointestinal Diseases;

2011
Fructose malabsorption: how much fructose can a healthy subject tolerate?
    Digestion, 2011, Volume: 84, Issue:4

    Topics: Abdominal Pain; Adolescent; Adult; Breath Tests; Diarrhea; Diet Records; Female; Flatulence; Fructos

2011
Reassessment of the role of methane production between irritable bowel syndrome and functional constipation.
    Journal of gastrointestinal and liver diseases : JGLD, 2012, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Bacteria; Breath Tests; Constipation; Defec

2012
Lactose intolerance: analysis of underlying factors.
    European journal of clinical investigation, 2003, Volume: 33, Issue:1

    Topics: Adult; Age Factors; beta-Galactosidase; Breath Tests; Carbon Isotopes; Diarrhea; Digestion; Female;

2003
IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen.
    Digestive diseases and sciences, 2004, Volume: 49, Issue:1

    Topics: Adolescent; Adult; Aged; Breath Tests; Chromatography, High Pressure Liquid; Constipation; Diarrhea;

2004
Maximum permissive dosage of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults.
    Journal of nutritional science and vitaminology, 2005, Volume: 51, Issue:2

    Topics: Adult; Blood Glucose; Breath Tests; Diarrhea; Digestion; Dose-Response Relationship, Drug; Female; F

2005
Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults.
    Journal of the American Dietetic Association, 2005, Volume: 105, Issue:10

    Topics: Abdominal Pain; Adult; Area Under Curve; Breath Tests; Diarrhea; Dietary Carbohydrates; Dose-Respons

2005
[Study of intestinal time in patients with chronic pancreatitis with the help of hydrogen breath test].
    Voprosy pitaniia, 2007, Volume: 76, Issue:4

    Topics: Adolescent; Adult; Bacteria; Breath Tests; Child; Child, Preschool; Diarrhea; Female; Humans; Hydrog

2007
Bacterial contamination of the small intestine as an important cause of chronic diarrhea and abdominal pain: diagnosis by breath hydrogen test.
    Pediatrics, 1984, Volume: 74, Issue:2

    Topics: Abdomen; Administration, Oral; Anti-Bacterial Agents; Bacterial Infections; beta-Galactosidase; Brea

1984
Fasting breath hydrogen concentration: normal values and clinical application.
    Gastroenterology, 1984, Volume: 87, Issue:6

    Topics: Abdomen; Adolescent; Adult; Aged; Bacterial Infections; Breath Tests; Child; Child, Preschool; Chron

1984
Detection of fructose malabsorption by breath hydrogen test in a child with diarrhea.
    The Journal of pediatrics, 1983, Volume: 103, Issue:4

    Topics: Breath Tests; Carbohydrate Metabolism, Inborn Errors; Child; Diarrhea; Female; Fructose Intolerance;

1983
Breath hydrogen test after oral lactose in postgastrectomy patients.
    The American journal of clinical nutrition, 1980, Volume: 33, Issue:11

    Topics: Animals; beta-Galactosidase; Blood Glucose; Breath Tests; Diarrhea; Female; Gastrectomy; Humans; Hyd

1980
Effect of lactate and H+ on structure and function of rat intestine.
    Digestive diseases and sciences, 1982, Volume: 27, Issue:1

    Topics: Animals; Carboxymethylcellulose Sodium; Colon; Diarrhea; Hydrogen; Ileum; Intestinal Mucosa; Ions; L

1982
Excess pulmonary excretion of hydrogen in response to lactulose.
    Acta paediatrica Scandinavica, 1980, Volume: 69, Issue:5

    Topics: Child; Diarrhea; Disaccharides; Humans; Hydrogen; Lactulose; Lung

1980
[Chronic diarrhea. New aspects of diagnosis and therapy].
    Fortschritte der Medizin, 1981, Oct-15, Volume: 99, Issue:39

    Topics: Anti-Bacterial Agents; Breath Tests; Charcoal; Cholestyramine Resin; Chronic Disease; Diarrhea; Gluc

1981
Mucosal function and breath hydrogen excretion: comparative studies in the clinical evaluation of children with nonspecific abdominal complaints.
    Pediatrics, 1981, Volume: 68, Issue:4

    Topics: Abdomen; Adolescent; Adult; Breath Tests; Child; Child, Preschool; Diarrhea; Disaccharidases; Evalua

1981
Diagnostic value of sucrose tolerance test in children evaluated by breath hydrogen measurement.
    Acta paediatrica Scandinavica, 1980, Volume: 69, Issue:1

    Topics: Adolescent; Blood Glucose; Breath Tests; Child; Child, Preschool; Diarrhea; Diarrhea, Infantile; Dis

1980
Malabsorption syndromes including disease of pancreatic and biliary origin.
    Current concepts in nutrition, 1980, Volume: 9

    Topics: Bile Acids and Salts; Breath Tests; Celiac Disease; Diarrhea; Enterobacteriaceae; Exocrine Pancreati

1980
D-xylose hydrogen breath tests compared to absorption kinetics in human patients with and without malabsorption.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:10

    Topics: Administration, Oral; Biopsy; Breath Tests; Diarrhea; Dose-Response Relationship, Drug; Duodenum; Hu

1995
Colchicine-induced lactose malabsorption in patients with familial Mediterranean fever.
    Israel journal of medical sciences, 1995, Volume: 31, Issue:10

    Topics: Abdominal Pain; Adolescent; Adult; Breath Tests; Case-Control Studies; Child; Child, Preschool; Colc

1995
Colonic fermentation: metabolic and clinical implications.
    The Clinical investigator, 1994, Volume: 72, Issue:10

    Topics: Acetates; Acetic Acid; Anaerobiosis; Animals; Butyrates; Butyric Acid; Cell Division; Colitis, Ulcer

1994
In vivo study of colonic fermentation of carbohydrate in infants.
    Journal of pediatric gastroenterology and nutrition, 1995, Volume: 20, Issue:1

    Topics: Acetates; Brazil; Breath Tests; Carbon Isotopes; Colon; Diarrhea; Dietary Carbohydrates; Enteral Nut

1995
Fructose malabsorption in a child with chronic diarrhea.
    Journal of pediatric gastroenterology and nutrition, 1994, Volume: 18, Issue:1

    Topics: Absorption; Biopsy; Child, Preschool; Chronic Disease; Diarrhea; Fructose; Humans; Hydrogen; Intesti

1994
Delta 10 ppm versus delta 20 ppm: a reappraisal of diagnostic criteria for breath hydrogen testing in children.
    The American journal of gastroenterology, 1994, Volume: 89, Issue:5

    Topics: Abdominal Pain; Breath Tests; Child; Child, Preschool; Diarrhea; Flatulence; Humans; Hydrogen; Lacto

1994
[Evaluation of small intestinal motility].
    Schweizerische medizinische Wochenschrift. Supplementum, 1993, Volume: 54

    Topics: Breath Tests; Constipation; Diarrhea; Gastrointestinal Motility; Gastrointestinal Transit; Humans; H

1993
Fructose breath hydrogen tests.
    Archives of disease in childhood, 1993, Volume: 68, Issue:1

    Topics: Breath Tests; Child; Child, Preschool; Diarrhea; Female; Fructose; Glucose; Humans; Hydrogen; Infant

1993
Fruit juice and chronic nonspecific diarrhea.
    The Journal of pediatrics, 1993, Volume: 122, Issue:3

    Topics: Breath Tests; Child; Child, Preschool; Chronic Disease; Diarrhea; Fructose; Fruit; Humans; Hydrogen;

1993
The relationship between lactose tolerance test results and symptoms of lactose intolerance.
    The American journal of gastroenterology, 1997, Volume: 92, Issue:6

    Topics: Adult; Blood Glucose; Diarrhea; Female; Flatulence; Humans; Hydrogen; Intestinal Diseases; Lactose;

1997
Evaluation of the rice breath hydrogen test for small intestinal bacterial overgrowth.
    The American journal of gastroenterology, 2000, Volume: 95, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Colony Count, Microbial; Diarrhea; Enterob

2000
Glucose and galactose absorption after ingestion of milk containing hydrolysed lactose in calves with diarrhoea.
    Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 2000, Volume: 47, Issue:8

    Topics: Animals; Area Under Curve; beta-Galactosidase; Blood Glucose; Cattle; Cattle Diseases; Diarrhea; Fem

2000
Breath hydrogen as a diagnostic method for hypolactasia.
    Lancet (London, England), 1975, May-24, Volume: 1, Issue:7917

    Topics: Biopsy; Blood Glucose; Breath Tests; Diarrhea; Flatulence; Humans; Hydrogen; Jejunum; Lactose; Lacto

1975
Delayed small-intestinal transit in tropical malabsorption.
    British medical journal, 1978, Jul-22, Volume: 2, Issue:6132

    Topics: Administration, Oral; Adult; Breath Tests; Diarrhea; Female; Gastrointestinal Motility; Humans; Hydr

1978
Use of breath hydrogen (H2) in the study of carbohydrate absorption.
    The American journal of digestive diseases, 1977, Volume: 22, Issue:4

    Topics: Diarrhea; Dietary Carbohydrates; Feces; Humans; Hydrogen; Intestinal Absorption; Intestines; Malabso

1977
Use of breath hydrogen (H2) to quantitate small bowel transit time following partial gastrectomy.
    The Journal of laboratory and clinical medicine, 1977, Volume: 90, Issue:1

    Topics: Breath Tests; Diarrhea; Gastrectomy; Gastrointestinal Motility; Glucose; Humans; Hydrogen; Intestina

1977
Lactose intolerance, detected by the hydrogen breath test, in infants and children with chronic diarrhoea.
    Archives of disease in childhood, 1977, Volume: 52, Issue:10

    Topics: Adolescent; Breath Tests; Celiac Disease; Child; Child, Preschool; Chronic Disease; Diarrhea; Humans

1977
[Fructose malabsorption and dysfunctional gastrointestinal manifestations].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1992, Volume: 140, Issue:11

    Topics: Abdominal Pain; Adolescent; Breath Tests; Child; Child, Preschool; Diarrhea; Female; Fructose; Fruct

1992
Glucose malabsorption associated with rapid intestinal transit.
    The American journal of gastroenterology, 1992, Volume: 87, Issue:5

    Topics: Adult; Aged; Breath Tests; Chronic Disease; Diarrhea; Female; Gastrointestinal Transit; Glucose; Hum

1992
[Lactase deficiency and lactose intolerance-related symptoms in adult healthy subjects from western France].
    Gastroenterologie clinique et biologique, 1991, Volume: 15, Issue:8-9

    Topics: Abdominal Pain; Adolescent; Adult; beta-Galactosidase; Diarrhea; Female; Flatulence; France; Humans;

1991
A pattern of breath hydrogen excretion suggesting small bowel bacterial overgrowth in Burmese village children.
    Journal of pediatric gastroenterology and nutrition, 1991, Volume: 13, Issue:1

    Topics: Breath Tests; Child, Preschool; Diarrhea; Female; Humans; Hydrogen; Infant; Intestine, Small; Lactul

1991
[Monitoring of postoperative enteral feeding using the H2 breath test].
    Infusionstherapie (Basel, Switzerland), 1991, Volume: 18, Issue:1

    Topics: Abdomen; Breath Tests; Diarrhea; Enteral Nutrition; Gastrointestinal Transit; Humans; Hydrogen; Jeju

1991
[Diagnostic potential of a new functional test used in intestinal diseases--determination of hydrogen in exhaled air].
    Terapevticheskii arkhiv, 1991, Volume: 63, Issue:2

    Topics: beta-Galactosidase; Breath Tests; Chronic Disease; Diarrhea; Gastrointestinal Transit; Humans; Hydro

1991
Gastrointestinal dysfunction and disaccharide intolerance in children infected with human immunodeficiency virus.
    The Journal of pediatrics, 1991, Volume: 118, Issue:3

    Topics: Breath Tests; Child; Child, Preschool; Diarrhea; Disaccharides; Duodenum; Feces; HIV Infections; Hum

1991
Gastrointestinal transit of solid-liquid meal in chronic alcoholics.
    Digestive diseases and sciences, 1991, Volume: 36, Issue:7

    Topics: Adult; Aged; Alcoholism; Autonomic Nervous System Diseases; Breath Tests; Constipation; Diarrhea; Fe

1991
[Chronic diarrhea in children. Possibilities of differential diagnosis using the hydrogen exhalation test].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 1990, Volume: 9, Issue:12

    Topics: Breath Tests; Chronic Disease; Diagnosis, Differential; Diarrhea; Gastrointestinal Transit; Humans;

1990
Value of breath hydrogen test in detection of hypolactasia in patients with chronic diarrhoea.
    Journal of chromatography, 1990, Aug-24, Volume: 530, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; beta-Galactosidase; Breath Tests; Child; Child, Preschoo

1990
Diarrhea in diabetics: the role of sorbitol.
    Journal of the American College of Nutrition, 1990, Volume: 9, Issue:6

    Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Breath Tests; Diabetes Complications; Diarrhea; Drug

1990
Gastrointestinal and metabolic effects of amylase inhibition in diabetics.
    Gastroenterology, 1988, Volume: 94, Issue:2

    Topics: Aged; Amylases; Blood Glucose; Breath Tests; C-Peptide; Diabetes Mellitus, Type 2; Diarrhea; Dietary

1988
Defective jejunal brush-border Na+/H+ exchange: a cause of congenital secretory diarrhoea.
    Lancet (London, England), 1985, May-11, Volume: 1, Issue:8437

    Topics: Cell Membrane; Child; Child, Preschool; Diarrhea; Female; Humans; Hydrogen; Infant; Infant, Newborn;

1985
Lactase deficiency. Diagnosis and management.
    Hospital practice (Office ed.), 1987, Jan-30, Volume: 22, Issue:1A

    Topics: Adult; beta-Galactosidase; Blood Glucose; Breath Tests; Celiac Disease; Colonic Diseases, Functional

1987
13CO2 breath test using naturally 13C-enriched lactose for detection of lactase deficiency in patients with gastrointestinal symptoms.
    The Journal of laboratory and clinical medicine, 1988, Volume: 112, Issue:2

    Topics: Abdomen; Adolescent; Adult; Aged; Aged, 80 and over; beta-Galactosidase; Breath Tests; Carbon Dioxid

1988
Comparison of noninvasive breath hydrogen test for gastric acid secretion to standard intubation test in infants and young children.
    Digestive diseases and sciences, 1987, Volume: 32, Issue:9

    Topics: Acute Disease; Betazole; Breath Tests; Child, Preschool; Diarrhea; Evaluation Studies as Topic; Fema

1987
Use of pulmonary hydrogen gas excretion to detect carbohydrate malabsorption in dogs.
    Journal of the American Veterinary Medical Association, 1986, Sep-15, Volume: 189, Issue:6

    Topics: Animals; Carbohydrate Metabolism; Chronic Disease; Diarrhea; Dog Diseases; Dogs; Exocrine Pancreatic

1986
Is the diarrhoea in ulcerative colitis related to impaired colonic salvage of carbohydrate?
    Gut, 1987, Volume: 28, Issue:9

    Topics: Adult; Aged; Breath Tests; Colitis, Ulcerative; Colon; Diarrhea; Disaccharides; Feces; Female; Human

1987
Intestinal-transit and lactose intolerance in chronic alcoholics.
    The American journal of clinical nutrition, 1986, Volume: 44, Issue:1

    Topics: Adult; Alcoholism; Breath Tests; Diarrhea; Digestion; Gastrointestinal Motility; Humans; Hydrogen; I

1986
Congenital Na+ diarrhea: a new type of secretory diarrhea.
    The Journal of pediatrics, 1985, Volume: 106, Issue:1

    Topics: Acidosis; Adolescent; Aldosterone; Citrates; Citric Acid; Diarrhea; Electrolytes; Feces; Female; Gas

1985
Limited efficacy of early postoperative jejunal feeding.
    American journal of surgery, 1985, Volume: 150, Issue:1

    Topics: Breath Tests; Diarrhea; Enteral Nutrition; Food Additives; Food, Formulated; Gastrointestinal Diseas

1985
Apple juice. An unappreciated cause of chronic diarrhea.
    American journal of diseases of children (1960), 1985, Volume: 139, Issue:5

    Topics: Breath Tests; Carbohydrates; Child, Preschool; Chromatography, Gas; Chronic Disease; Diarrhea; Fruit

1985
Value of breath hydrogen analysis in management of diarrheal illness in childhood: comparison with duodenal biopsy.
    Journal of pediatric gastroenterology and nutrition, 1985, Volume: 4, Issue:3

    Topics: Biopsy; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Child, Preschool; Diarrhea; Duodenum;

1985
Sorbitol intolerance in adults.
    The American journal of gastroenterology, 1985, Volume: 80, Issue:9

    Topics: Abdomen; Adult; Black People; Breath Tests; Colonic Diseases, Functional; Diagnosis, Differential; D

1985
Small intestine transit time and lactose absorption during phototherapy.
    Biology of the neonate, 1985, Volume: 48, Issue:1

    Topics: Breath Tests; Diarrhea; Gastrointestinal Motility; Humans; Hydrogen; Hyperbilirubinemia; Infant, New

1985
Treatment of intestinal gas cysts by oxygen breathing.
    Lancet (London, England), 1973, Mar-17, Volume: 1, Issue:7803

    Topics: Biopsy; Diarrhea; Humans; Hydrogen; Male; Middle Aged; Oxygen; Oxygen Inhalation Therapy; Pneumatosi

1973