Page last updated: 2024-10-18

hydrogen and Chronic Lung Injury

hydrogen has been researched along with Chronic Lung Injury in 12 studies

Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.

Research Excerpts

ExcerptRelevanceReference
" Hydrogen gas provides potent anti-inflammatory and antioxidant effects against ischemia-reperfusion injury (IRI)."7.91Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death. ( Deng, L; Li, W; Liu, J; Meng, C; Zhang, J; Zhou, H, 2019)
"Lung ischemia-reperfusion injury (IRI) may be attenuated through carbon monoxide (CO)'s anti-inflammatory effect or hydrogen (H2)'s anti-oxidant effect."7.83Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats. ( Cui, X; Jiang, C; Kang, J; Liu, J; Liu, R; Ma, L; Meng, C; Niu, L; Xing, J; Zhou, H, 2016)
"High concentrations of hydrogen could ameliorate pulmonary dysfunction, airway mucus hypersecretion, oxidation damage, and inflammation response in rats exposed to concentrated ambient PM2."3.91Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 via Aryl hydrocarbon receptor. ( Chao, L; Duan, E; Feng, S; Li, H; Li, R; Shi, X; Yan, X; Zhang, H; Zhang, W; Zhao, Y; Zhong, X, 2019)
" Hydrogen gas provides potent anti-inflammatory and antioxidant effects against ischemia-reperfusion injury (IRI)."3.91Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death. ( Deng, L; Li, W; Liu, J; Meng, C; Zhang, J; Zhou, H, 2019)
"Lung ischemia-reperfusion injury (IRI) may be attenuated through carbon monoxide (CO)'s anti-inflammatory effect or hydrogen (H2)'s anti-oxidant effect."3.83Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats. ( Cui, X; Jiang, C; Kang, J; Liu, J; Liu, R; Ma, L; Meng, C; Niu, L; Xing, J; Zhou, H, 2016)
"Hydrogen has antioxidant and anti-inflammatory effects on lung ischemia-reperfusion injury when it is inhaled by donor or/and recipient."3.81Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. ( Fang, X; Li, W; Liu, J; Liu, R; Meng, C; Xing, J; Yang, W; Zhou, H, 2015)
"The results of this study demonstrate that hydrogen-rich saline ameliorated hyperoxia-induced acute lung injury by reducing oxidative stress and inflammatory cascades in lung tissue."3.77Hydrogen-rich saline provides protection against hyperoxic lung injury. ( Cai, J; Liu, S; Liu, Y; Sun, Q; Sun, X; Tao, H; Xu, W, 2011)
"Hydrogen has been demonstrated to have effective protection against tissue injuries caused by oxidative stress, inflammation, and apoptosis."1.42Hydrogen water alleviates lung injury induced by one-lung ventilation. ( Fu, J; Liu, C; Song, S; Wan, Y; Wu, Q; Zhang, G; Zhang, J; Zhang, Y, 2015)
"Hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression."1.39Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. ( Billiar, TR; Huang, CS; Kawamura, T; Kensler, TW; Masutani, K; Nakao, A; Noda, K; Okumura, M; Peng, X; Shigemura, N; Takahashi, T; Tanaka, Y; Toyoda, Y; Wakabayashi, N, 2013)
"Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappaB activation and the pro-inflammatory cytokine interleukin IL-1beta and TNF-alpha in the lung tissues compared with those in saline-treated rat."1.35Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. ( Cai, JM; Deng, XM; Jiang, L; Mao, YF; Sun, XJ; You, XM; Zhang, JH; Zheng, XF, 2009)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's8 (66.67)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Ageta, K1
Hirayama, T1
Aokage, T1
Seya, M1
Meng, Y1
Nojima, T1
Yamamoto, H1
Obara, T1
Nakao, A2
Yumoto, T1
Tsukahara, K1
Naito, H1
Wang, Y1
Fan, Y1
Jiang, Y1
Wang, E1
Song, Y1
Chen, H1
Xu, F1
Xie, K1
Yu, Y1
Feng, S1
Duan, E1
Shi, X1
Zhang, H1
Li, H1
Zhao, Y1
Chao, L1
Zhong, X1
Zhang, W1
Li, R1
Yan, X1
Quan, L1
Zheng, B1
Zhou, H4
Zhang, J2
Liu, J3
Meng, C3
Deng, L1
Li, W2
Kawamura, T1
Wakabayashi, N1
Shigemura, N1
Huang, CS1
Masutani, K1
Tanaka, Y1
Noda, K1
Peng, X1
Takahashi, T1
Billiar, TR1
Okumura, M1
Toyoda, Y1
Kensler, TW1
Liu, R2
Fang, X1
Xing, J2
Yang, W1
Wu, Q1
Wan, Y1
Song, S1
Zhang, Y1
Zhang, G1
Liu, C1
Fu, J1
Ma, L1
Niu, L1
Cui, X1
Kang, J1
Jiang, C1
Mao, YF1
Zheng, XF1
Cai, JM1
You, XM1
Deng, XM1
Zhang, JH1
Jiang, L1
Sun, XJ1
Sun, Q1
Cai, J1
Liu, S1
Liu, Y1
Xu, W1
Tao, H1
Sun, X1
Chen, HG1
Xie, KL1
Han, HZ1
Yu, YH1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Hydrogen Inhalation on Bronchiectasis (HYBRID): A Randomized, Multi-center, Double-blind, Parallel-group Study[NCT02765295]120 participants (Anticipated)Interventional2016-06-01Recruiting
Adjuvant Therapy for Severe COPD Patients in the Stable Phase by an Oxyhydrogen Generator With Nebulizer: A Multi-centric, Randomized, Parallel-control and Double-blinded Clinic Study[NCT02850185]170 participants (Anticipated)Interventional2016-07-15Recruiting
Adjuvant Therapy for Severe Asthma by an Oxyhydrogen Generator With Nebulizer: A Multi-centric, Randomized, Parallel-control and Double-blinded Clinic Study on Effectiveness and Safety[NCT02883582]150 participants (Anticipated)Interventional2016-08-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for hydrogen and Chronic Lung Injury

ArticleYear
Protective effects of molecular hydrogen on lung injury from lung transplantation.
    Experimental biology and medicine (Maywood, N.J.), 2021, Volume: 246, Issue:12

    Topics: Animals; Humans; Hydrogen; Inflammation; Lung; Lung Injury; Lung Transplantation; Oxidative Stress

2021
[The mechanisms for the lung tissue protective effects of hydrogen : recent progress in mice study].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2011, Volume: 23, Issue:11

    Topics: Animals; Hydrogen; Lung; Lung Injury; Mice; Oxidative Stress

2011

Other Studies

10 other studies available for hydrogen and Chronic Lung Injury

ArticleYear
Hydrogen inhalation attenuates lung contusion after blunt chest trauma in mice.
    Surgery, 2023, Volume: 174, Issue:2

    Topics: Acute Lung Injury; Animals; Contusions; Hydrogen; Lung; Lung Injury; Male; Mice; Mice, Inbred C57BL;

2023
APOA2: New Target for Molecular Hydrogen Therapy in Sepsis-Related Lung Injury Based on Proteomic and Genomic Analysis.
    International journal of molecular sciences, 2023, Jul-11, Volume: 24, Issue:14

    Topics: Animals; Apolipoprotein A-II; Biomarkers; Diabetes Mellitus, Type 2; Genetic Predisposition to Disea

2023
Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 via Aryl hydrocarbon receptor.
    International immunopharmacology, 2019, Volume: 77

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cytokines; Disease Models, Animal; Hydrogen;

2019
Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death.
    Microvascular research, 2019, Volume: 125

    Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Disease Mode

2019
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla

2013
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla

2013
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla

2013
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla

2013
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla

2013
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla

2013
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla

2013
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla

2013
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Animals; Apoptosis; Cytokines; Epithelial Cells; Gases; Heme Oxygenase-1; Hydrogen; Hyperoxia; Infla

2013
Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats.
    Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:9

    Topics: Animals; Antioxidants; Apoptosis; Cold Ischemia; Hydrogen; Lung Compliance; Lung Injury; Lung Transp

2015
Hydrogen water alleviates lung injury induced by one-lung ventilation.
    The Journal of surgical research, 2015, Volume: 199, Issue:2

    Topics: Animals; Drug Evaluation, Preclinical; Hydrogen; Interleukin-1beta; Interleukin-6; Lung; Lung Injury

2015
Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats.
    Life sciences, 2016, Apr-15, Volume: 151

    Topics: Animals; Apoptosis; Blood Gas Analysis; Carbon Monoxide; Cold Ischemia; Drug Synergism; Hydrogen; In

2016
Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.
    Biochemical and biophysical research communications, 2009, Apr-17, Volume: 381, Issue:4

    Topics: Animals; Cell Membrane; Hydrogen; Interleukin-1beta; Intestines; Lipid Peroxidation; Lung Injury; Ma

2009
Hydrogen-rich saline provides protection against hyperoxic lung injury.
    The Journal of surgical research, 2011, Volume: 165, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj

2011
Hydrogen-rich saline provides protection against hyperoxic lung injury.
    The Journal of surgical research, 2011, Volume: 165, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj

2011
Hydrogen-rich saline provides protection against hyperoxic lung injury.
    The Journal of surgical research, 2011, Volume: 165, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj

2011
Hydrogen-rich saline provides protection against hyperoxic lung injury.
    The Journal of surgical research, 2011, Volume: 165, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj

2011
Hydrogen-rich saline provides protection against hyperoxic lung injury.
    The Journal of surgical research, 2011, Volume: 165, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj

2011
Hydrogen-rich saline provides protection against hyperoxic lung injury.
    The Journal of surgical research, 2011, Volume: 165, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj

2011
Hydrogen-rich saline provides protection against hyperoxic lung injury.
    The Journal of surgical research, 2011, Volume: 165, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj

2011
Hydrogen-rich saline provides protection against hyperoxic lung injury.
    The Journal of surgical research, 2011, Volume: 165, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj

2011
Hydrogen-rich saline provides protection against hyperoxic lung injury.
    The Journal of surgical research, 2011, Volume: 165, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Hydrogen; Hyperoxia; Lung; Lung Inj

2011