hydrogen has been researched along with Cerebral Ischemia in 59 studies
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II) trial is an investigator-initiated, randomized, double-blind, placebo-controlled trial designed to enroll 360 adult comatose (Glasgow Coma Scale score < 8) patients who will be resuscitated following an out-of-hospital cardiac arrest of a presumed cardiac cause." | 9.24 | Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial. ( Hayashida, K; Onuki, S; Sano, M; Suzuki, M; Tamura, T, 2017) |
| "Hydrogen treatment could potentially be a future therapeutic strategy for ischemia and its derived neurodegenerative diseases by improving cognitive abilities and inducing antioxidative and antiapoptotic effects." | 8.02 | Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model. ( Choi, JI; Lee, D, 2021) |
| "The aim of this study was to investigate whether a hydrogen administration can produce neuroprotective effects after brain ischemia reperfusion in rats." | 7.83 | The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats. ( Liu, T; Wang, X; Zhang, L; Zhao, W, 2016) |
| "To investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats." | 7.81 | [Role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion injury in rats]. ( Chen, X; Dai, Q; Duan, M; Gao, Y; Wu, L; Xu, J; Yu, P; Zhang, L; Zhao, L, 2015) |
| "Molecular hydrogen has been proven effective in ameliorating cerebral ischemia/reperfusion (I/R) injury by selectively neutralizing reactive oxygen species." | 7.79 | Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. ( Bi, H; Chen, X; Kang, Z; Li, M; Liu, W; Shi, D; Shi, J; Sun, X; Wang, Q; Ye, Z; Zhai, X, 2013) |
| " This study investigates the utilization of glutamate, glutamine, and GABA as fuel by the neuronal and glial tricarboxylic acid cycles of both cerebral hemispheres after partially reversible focal cerebral ischemia (FCI)." | 7.70 | Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. ( Carceller, F; Cerdán, S; Pascual, JM; Roda, JM, 1998) |
| " The aim of this study was to examine the rapid changes in extracellular hydrogen ion activity [( H+]o or pHo) which are associated with depolarization and repolarization subsequent to cerebral ischemia reperfusion." | 7.68 | A rapid redistribution of hydrogen ions is associated with depolarization and repolarization subsequent to cerebral ischemia reperfusion. ( Höller, M; Matsumoto, T; Obrenovitch, TP; Scheller, D; Symon, L; Tegtmeier, F, 1990) |
| "Hydrogen gas has been found to eliminate hydroxyl free radical and peroxynitrite anions as well as producing therapeutic effect in patients with ischemic stroke." | 6.61 | Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence. ( Li, H; Liu, J; Luo, Y; Yang, P, 2019) |
| "Hydrogen is a kind of noble gas with the character to selectively neutralize reactive oxygen species." | 5.43 | Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats - A possible new hydrogen resource for clinical use. ( Cao, L; Chen, X; Cui, J; Gu, Z; Hou, J; Ji, F; Li, X; Shi, D; Su, J; Sun, X; Wang, L; Weng, W; Zhai, X; Zhang, J; Zhang, R; Zhi, X, 2016) |
| "Hydrogen-rich saline treatment significantly improved the amount of surviving cells (P < 0." | 5.40 | Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats. ( Chen, H; Cui, Y; Duan, M; Ji, M; Jia, M; Yang, J; Zhang, H, 2014) |
| "Global cerebral ischemia and reperfusion (I/R) often result in high mortality." | 5.38 | Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia. ( Fujita, M; Kobayashi, H; Nagatani, K; Nawashiro, H; Otani, N; Tachibana, S; Takeuchi, S; Uozumi, Y; Wada, K, 2012) |
| "Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time." | 5.37 | Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. ( Bari, F; Domoki, F; Farkas, E; Hertelendy, P; Hugyecz, M; Mracskó, E, 2011) |
| "The efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II) trial is an investigator-initiated, randomized, double-blind, placebo-controlled trial designed to enroll 360 adult comatose (Glasgow Coma Scale score < 8) patients who will be resuscitated following an out-of-hospital cardiac arrest of a presumed cardiac cause." | 5.24 | Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial. ( Hayashida, K; Onuki, S; Sano, M; Suzuki, M; Tamura, T, 2017) |
| "Hydrogen treatment could potentially be a future therapeutic strategy for ischemia and its derived neurodegenerative diseases by improving cognitive abilities and inducing antioxidative and antiapoptotic effects." | 4.02 | Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model. ( Choi, JI; Lee, D, 2021) |
| "The aim of this study was to investigate whether a hydrogen administration can produce neuroprotective effects after brain ischemia reperfusion in rats." | 3.83 | The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats. ( Liu, T; Wang, X; Zhang, L; Zhao, W, 2016) |
| "To investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats." | 3.81 | [Role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion injury in rats]. ( Chen, X; Dai, Q; Duan, M; Gao, Y; Wu, L; Xu, J; Yu, P; Zhang, L; Zhao, L, 2015) |
| "Molecular hydrogen has been proven effective in ameliorating cerebral ischemia/reperfusion (I/R) injury by selectively neutralizing reactive oxygen species." | 3.79 | Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. ( Bi, H; Chen, X; Kang, Z; Li, M; Liu, W; Shi, D; Shi, J; Sun, X; Wang, Q; Ye, Z; Zhai, X, 2013) |
| "The purpose of this study was to test the hypothesis that the efficacy of 7-nitroindazole (7-NI), a selective neuronal nitric oxide (NO) synthase (NOS) inhibitor, is pH dependent in vivo during focal cerebral ischemia." | 3.72 | Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH? ( Anderson, RE; Coert, BA; Meyer, FB, 2003) |
| " This study investigates the utilization of glutamate, glutamine, and GABA as fuel by the neuronal and glial tricarboxylic acid cycles of both cerebral hemispheres after partially reversible focal cerebral ischemia (FCI)." | 3.70 | Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. ( Carceller, F; Cerdán, S; Pascual, JM; Roda, JM, 1998) |
| " First, in patients with cerebral infarctions, increased concentrations of lactate were found in the majority of patients, and N-acetyl aspartate (NAA) was reduced to a significantly greater extent than choline (Cho) or creatine (Cre)." | 3.68 | Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities. ( Calabrese, G; Deicken, R; Fein, G; Fisher, SN; Hetherington, HP; Sappey-Marinier, D; Van Dyke, C; Weiner, MW, 1992) |
| " The aim of this study was to examine the rapid changes in extracellular hydrogen ion activity [( H+]o or pHo) which are associated with depolarization and repolarization subsequent to cerebral ischemia reperfusion." | 3.68 | A rapid redistribution of hydrogen ions is associated with depolarization and repolarization subsequent to cerebral ischemia reperfusion. ( Höller, M; Matsumoto, T; Obrenovitch, TP; Scheller, D; Symon, L; Tegtmeier, F, 1990) |
| "In 27 cats treated to vary arterial serum glucose concentrations, we measured cerebral high-energy phosphate metabolite concentration and intracellular pH using in vivo phosphorus-31 nuclear magnetic resonance spectroscopy during transient global cerebral ischemia and reperfusion." | 3.67 | Global cerebral ischemia and intracellular pH during hyperglycemia and hypoglycemia in cats. ( Chopp, M; Helpern, JA; Tidwell, CD; Welch, KM, 1988) |
| "Hydrogen gas has been found to eliminate hydroxyl free radical and peroxynitrite anions as well as producing therapeutic effect in patients with ischemic stroke." | 2.61 | Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence. ( Li, H; Liu, J; Luo, Y; Yang, P, 2019) |
| "Two diseases are considered in detail: cerebral ischemia (including stroke and neonatal ischemic/hypoxic injury) and cancer; a further section briefly reviews studies on other diseases." | 2.38 | Proton spectroscopy in vivo. ( Brown, MM; Griffiths, JR; Howe, FA; Maxwell, RJ; Saunders, DE, 1993) |
| "Hydrogen is a kind of noble gas with the character to selectively neutralize reactive oxygen species." | 1.43 | Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats - A possible new hydrogen resource for clinical use. ( Cao, L; Chen, X; Cui, J; Gu, Z; Hou, J; Ji, F; Li, X; Shi, D; Su, J; Sun, X; Wang, L; Weng, W; Zhai, X; Zhang, J; Zhang, R; Zhi, X, 2016) |
| "Focal brain ischemia was induced in male Sprague-Dawley rats by middle cerebral artery occlusion (MCAO)." | 1.42 | Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. ( Han, L; Hao, S; Hou, Z; Li, YV; Liu, B; Pei, L; Tian, Q; Tian, R; Yan, H; Zhang, Q, 2015) |
| "Hydrogen-rich saline treatment significantly improved the amount of surviving cells (P < 0." | 1.40 | Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats. ( Chen, H; Cui, Y; Duan, M; Ji, M; Jia, M; Yang, J; Zhang, H, 2014) |
| "Global cerebral ischemia and reperfusion (I/R) often result in high mortality." | 1.38 | Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia. ( Fujita, M; Kobayashi, H; Nagatani, K; Nawashiro, H; Otani, N; Tachibana, S; Takeuchi, S; Uozumi, Y; Wada, K, 2012) |
| "Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time." | 1.37 | Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. ( Bari, F; Domoki, F; Farkas, E; Hertelendy, P; Hugyecz, M; Mracskó, E, 2011) |
| "Progressive cerebral ischemia was induced in seven anesthetized hyperglycemic rats by carotid artery ligation and hemorrhagic hypotension." | 1.27 | Metabolic changes during experimental cerebral ischemia in hyperglycemic rats, observed by 31P and 1H magnetic resonance spectroscopy. ( Bolas, NM; Mitsumori, F; Radda, GK; Rajagopalan, B, 1988) |
| "In dogs global cerebral ischemia was produced by clamping reversibly the left subclavian and brachiocephalic arteries, supplying the head." | 1.27 | Measurement of ischemic changes in cerebral blood flow by the hydrogen clearance technique and brain cortical temperature. Influence of flunarizine. ( Edmonds, HL; Marrannes, R; Melis, W; Van Loon, J; Wauquier, A, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (23.73) | 18.7374 |
| 1990's | 18 (30.51) | 18.2507 |
| 2000's | 5 (8.47) | 29.6817 |
| 2010's | 18 (30.51) | 24.3611 |
| 2020's | 4 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, D | 1 |
| Choi, JI | 1 |
| Pluta, R | 1 |
| Januszewski, S | 1 |
| Czuczwar, SJ | 1 |
| Hirano, M | 1 |
| Sugai, K | 1 |
| Fujisawa, M | 1 |
| Kobayashi, E | 1 |
| Katsumata, Y | 1 |
| Hakamata, Y | 1 |
| Sano, M | 2 |
| Liu, Y | 2 |
| Chu, M | 1 |
| Wang, D | 1 |
| Luo, Y | 2 |
| Liu, Z | 1 |
| Zhao, J | 1 |
| Li, D | 1 |
| Ai, Y | 1 |
| Tamura, T | 1 |
| Hayashida, K | 1 |
| Onuki, S | 1 |
| Suzuki, M | 1 |
| Jiang, X | 1 |
| Niu, X | 1 |
| Guo, Q | 1 |
| Dong, Y | 2 |
| Xu, J | 2 |
| Yin, N | 1 |
| Qi, Q | 1 |
| Jia, Y | 1 |
| Gao, L | 1 |
| He, Q | 1 |
| Lv, P | 1 |
| Wu, X | 1 |
| Li, X | 2 |
| Yuan, N | 1 |
| Li, C | 1 |
| Kang, Z | 2 |
| Zhang, X | 1 |
| Xia, Y | 1 |
| Hao, Y | 1 |
| Tan, Y | 1 |
| Li, H | 1 |
| Yang, P | 1 |
| Liu, J | 1 |
| Zhai, X | 2 |
| Chen, X | 4 |
| Shi, J | 1 |
| Shi, D | 2 |
| Ye, Z | 1 |
| Liu, W | 1 |
| Li, M | 1 |
| Wang, Q | 1 |
| Bi, H | 1 |
| Sun, X | 3 |
| Cui, Y | 1 |
| Zhang, H | 1 |
| Ji, M | 1 |
| Jia, M | 1 |
| Chen, H | 2 |
| Yang, J | 1 |
| Duan, M | 3 |
| Zhao, L | 1 |
| Dai, Q | 1 |
| Zhang, L | 2 |
| Yu, P | 2 |
| Gao, Y | 1 |
| Wu, L | 1 |
| Han, L | 1 |
| Tian, R | 1 |
| Yan, H | 1 |
| Pei, L | 1 |
| Hou, Z | 1 |
| Hao, S | 1 |
| Li, YV | 1 |
| Tian, Q | 1 |
| Liu, B | 1 |
| Zhang, Q | 1 |
| Li, Q | 1 |
| Zeng, Q | 1 |
| Luo, B | 1 |
| Cai, S | 1 |
| Hui, K | 1 |
| Yu, G | 1 |
| Zhu, C | 1 |
| Cui, J | 1 |
| Zhang, R | 1 |
| Zhi, X | 1 |
| Gu, Z | 1 |
| Cao, L | 1 |
| Weng, W | 1 |
| Zhang, J | 2 |
| Wang, L | 1 |
| Ji, F | 1 |
| Hou, J | 1 |
| Su, J | 1 |
| Wang, X | 2 |
| Zhao, W | 1 |
| Liu, T | 1 |
| Hugyecz, M | 1 |
| Mracskó, E | 1 |
| Hertelendy, P | 1 |
| Farkas, E | 1 |
| Domoki, F | 1 |
| Bari, F | 1 |
| Zhou, J | 1 |
| Wu, PF | 1 |
| Wang, F | 1 |
| Chen, JG | 1 |
| Nagatani, K | 1 |
| Wada, K | 1 |
| Takeuchi, S | 1 |
| Kobayashi, H | 1 |
| Uozumi, Y | 1 |
| Otani, N | 1 |
| Fujita, M | 1 |
| Tachibana, S | 1 |
| Nawashiro, H | 1 |
| Liu, C | 1 |
| Tai, M | 1 |
| Qu, K | 1 |
| Li, J | 1 |
| Han, H | 1 |
| Yu, Y | 1 |
| Wang, G | 1 |
| Zeng, Y | 1 |
| Xie, K | 1 |
| Sutherland, BA | 1 |
| Harrison, JC | 1 |
| Nair, SM | 1 |
| Sammut, IA | 1 |
| Anderson, RE | 3 |
| Meyer, FB | 3 |
| Coert, BA | 1 |
| Rytter, A | 1 |
| Cronberg, T | 1 |
| Asztély, F | 1 |
| Nemali, S | 1 |
| Wieloch, T | 1 |
| Tsuji, K | 1 |
| Aoki, T | 1 |
| Tejima, E | 1 |
| Arai, K | 1 |
| Lee, SR | 1 |
| Atochin, DN | 1 |
| Huang, PL | 1 |
| Montaner, J | 1 |
| Lo, EH | 1 |
| Constans, JM | 1 |
| Meyerhoff, DJ | 1 |
| Gerson, J | 1 |
| MacKay, S | 1 |
| Norman, D | 1 |
| Fein, G | 2 |
| Weiner, MW | 3 |
| Hendrich, K | 1 |
| Hu, X | 1 |
| Menon, RS | 1 |
| Merkle, H | 1 |
| Camarata, P | 1 |
| Heros, R | 1 |
| Uğurbil, K | 1 |
| Howe, FA | 1 |
| Maxwell, RJ | 1 |
| Saunders, DE | 1 |
| Brown, MM | 1 |
| Griffiths, JR | 1 |
| Brulatout, S | 1 |
| Méric, P | 1 |
| Loubinoux, I | 1 |
| Borredon, J | 1 |
| Corrèze, JL | 1 |
| Roucher, P | 1 |
| Gillet, B | 1 |
| Bérenger, G | 1 |
| Beloeil, JC | 1 |
| Tiffon, B | 1 |
| Mispelter, J | 1 |
| Seylaz, J | 1 |
| van der Toorn, A | 1 |
| Syková, E | 1 |
| Dijkhuizen, RM | 1 |
| Vorísek, I | 1 |
| Vargová, L | 1 |
| Skobisová, E | 1 |
| van Lookeren Campagne, M | 1 |
| Reese, T | 1 |
| Nicolay, K | 1 |
| Kramer, MS | 1 |
| Vinall, PE | 1 |
| Katolik, LI | 1 |
| Simeone, FA | 1 |
| Vornov, JJ | 1 |
| Thomas, AG | 1 |
| Jo, D | 1 |
| Tanabe, J | 1 |
| Mendelowitsch, A | 1 |
| Sekhar, LN | 1 |
| Caputy, AJ | 1 |
| Shuaib, A | 1 |
| Pascual, JM | 1 |
| Carceller, F | 1 |
| Roda, JM | 1 |
| Cerdán, S | 1 |
| Charbel, FT | 1 |
| Du, X | 1 |
| Hoffman, WE | 1 |
| Ausman, JI | 1 |
| Wang, Z | 1 |
| Bogdan, AR | 1 |
| Zimmerman, RA | 1 |
| Gusnard, DA | 1 |
| Leigh, JS | 2 |
| Ohene-Frempong, K | 1 |
| Sappey-Marinier, D | 1 |
| Calabrese, G | 1 |
| Hetherington, HP | 1 |
| Fisher, SN | 1 |
| Deicken, R | 1 |
| Van Dyke, C | 1 |
| Hurn, PD | 1 |
| Koehler, RC | 1 |
| Norris, SE | 1 |
| Blizzard, KK | 1 |
| Traystman, RJ | 1 |
| Iwama, T | 1 |
| Andoh, T | 1 |
| Sakai, N | 1 |
| Yamada, H | 1 |
| Era, S | 1 |
| Kuwata, K | 1 |
| Sogami, M | 1 |
| Watari, H | 1 |
| Obrenovitch, TP | 1 |
| Scheller, D | 1 |
| Matsumoto, T | 1 |
| Tegtmeier, F | 1 |
| Höller, M | 1 |
| Symon, L | 2 |
| Sundt, TM | 1 |
| Corbett, RJ | 1 |
| Laptook, AR | 1 |
| Chang, LH | 1 |
| Shirane, R | 1 |
| Weinstein, PR | 1 |
| James, TL | 1 |
| Kraig, RP | 2 |
| Pulsinelli, WA | 2 |
| Plum, F | 2 |
| Chopp, M | 1 |
| Welch, KM | 1 |
| Tidwell, CD | 1 |
| Helpern, JA | 1 |
| Allen, K | 3 |
| Busza, AL | 1 |
| Crockard, HA | 3 |
| Frackowiak, RS | 3 |
| Gadian, DG | 3 |
| Proctor, E | 3 |
| Russell, RW | 3 |
| Williams, SR | 3 |
| Higuchi, T | 1 |
| Naruse, S | 1 |
| Horikawa, Y | 1 |
| Tanaka, C | 1 |
| Ebisu, T | 1 |
| Yamamoto, K | 1 |
| Hirakawa, K | 1 |
| Boris-Möller, F | 1 |
| Drakenberg, T | 1 |
| Elmdén, K | 1 |
| Forsén, S | 1 |
| Siesjö, BK | 2 |
| Bolas, NM | 1 |
| Rajagopalan, B | 1 |
| Mitsumori, F | 1 |
| Radda, GK | 1 |
| Sutton, LN | 1 |
| McLaughlin, AC | 2 |
| Kemp, W | 1 |
| Schnall, MD | 1 |
| Cho, BK | 1 |
| Langfitt, TW | 1 |
| Chance, B | 2 |
| Gyulai, L | 1 |
| Schnall, M | 1 |
| Harris, RJ | 1 |
| Richards, PG | 1 |
| Habib, AH | 1 |
| Rosenstein, J | 1 |
| Marrannes, R | 1 |
| Edmonds, HL | 1 |
| Wauquier, A | 1 |
| Melis, W | 1 |
| Van Loon, J | 1 |
7 reviews available for hydrogen and Cerebral Ischemia
| Article | Year |
|---|---|
Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation-Fantasy or Reality?
Topics: Alzheimer Disease; Amyloid; Amyloidogenic Proteins; Animals; Brain Ischemia; Fantasy; Hydrogen; Isch | 2022 |
Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence.
Topics: Animals; Antioxidants; Brain Ischemia; Humans; Hydrogen; Stroke | 2019 |
Targeting gaseous molecules to protect against cerebral ischaemic injury: mechanisms and prospects.
Topics: Animals; Brain Ischemia; Carbon Monoxide; Cytoprotection; Drug Delivery Systems; Gases; Humans; Hydr | 2012 |
Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia.
Topics: Administration, Inhalation; Animals; Brain Ischemia; Carbon Monoxide; Clinical Trials as Topic; Drug | 2013 |
Proton spectroscopy in vivo.
Topics: Animals; Brain Ischemia; Humans; Hydrogen; Magnetic Resonance Spectroscopy; Neoplasms; Neoplasms, Ex | 1993 |
MRI-MRS of the brain in systemic lupus erythematosus. How do we use it to understand causes of clinical signs?
Topics: Brain; Brain Ischemia; Humans; Hydrogen; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; | 1997 |
Acid-base homeostasis in the brain: physiology, chemistry, and neurochemical pathology.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Bicarbonates; Brain; Brain Damage, Chronic; Brain Ischemia | 1985 |
1 trial available for hydrogen and Cerebral Ischemia
| Article | Year |
|---|---|
Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Brain Ischemia; Clinical Protocols; Comb | 2017 |
51 other studies available for hydrogen and Cerebral Ischemia
| Article | Year |
|---|---|
Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain Ischemia; Cognition; Deuterium Oxi | 2021 |
Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils.
Topics: Animals; Brain; Brain Ischemia; Cell Death; Gerbillinae; Hippocampus; Hydrogen; Ischemia; Ischemic A | 2022 |
Risk factors for small intestinal bacterial overgrowth in patients with acute ischaemic stroke.
Topics: Brain Ischemia; Breath Tests; Humans; Hydrogen; Intestine, Small; Methane; Risk Factors; Stroke | 2023 |
Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen‑activated protein kinase‑caspase‑3 signaling pathway following cerebral ischemia‑reperfusion injury.
Topics: Animals; Apoptosis; Brain Ischemia; Caspase 3; Gene Expression; Hydrogen; Immunohistochemistry; Male | 2017 |
FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia.
Topics: Animals; Apoptosis; Autophagy; Beclin-1; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Cogniti | 2019 |
Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway.
Topics: Animals; Apoptosis; Autophagy; Brain Ischemia; Cell Survival; Hippocampus; Hydrogen; Membrane Potent | 2018 |
Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression.
Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Hydrogen; Immunohistochemistry; In Situ Nick-End | 2013 |
Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats.
Topics: Animals; Antioxidants; Apoptosis; Brain Ischemia; Calcium; Cell Survival; Cytochromes c; Hydrogen; I | 2014 |
[Role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion injury in rats].
Topics: Animals; Brain Ischemia; Forkhead Box Protein O3; Forkhead Transcription Factors; Hippocampus; Hydro | 2015 |
Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins.
Topics: Animals; Brain Ischemia; Calcium; Glutamic Acid; Hippocalcin; Hydrogen; Infarction, Middle Cerebral | 2015 |
Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-κB Expression.
Topics: Animals; Apoptosis; Brain Ischemia; Hippocampus; Hydrogen; Male; MicroRNAs; Neuroprotective Agents; | 2016 |
Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats - A possible new hydrogen resource for clinical use.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Hydrogen; Male; Neurons; Neuroprotective Agents; Rats, Sp | 2016 |
The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats.
Topics: Animals; Brain Ischemia; Heme Oxygenase-1; Hydrogen; Malondialdehyde; Neuroprotective Agents; Rats; | 2016 |
Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Blood Pressure; Brain Ischemia; Connexins | 2011 |
Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Inhalation; Animals; Body Water; Brain; Brain Ischemia; | 2012 |
Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia (Shock 37(6), 645-652, 2012).
Topics: Animals; Brain Ischemia; Free Radical Scavengers; Hydrogen; Male; Mice; Reperfusion Injury | 2012 |
Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines.
Topics: Animals; Brain Ischemia; Cytokines; Disease Models, Animal; Hydrogen; Inflammation Mediators; Male; | 2012 |
Protection of focal cerebral ischemia by alkalinization of systemic pH.
Topics: Alkalies; Animals; Brain; Brain Ischemia; Carbonates; Cerebral Cortex; Cerebral Infarction; Cerebrov | 2002 |
Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH?
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Enzyme Inhibitors; | 2003 |
Mouse hippocampal organotypic tissue cultures exposed to in vitro "ischemia" show selective and delayed CA1 damage that is aggravated by glucose.
Topics: Animals; Brain Ischemia; Calcium; Cerebrospinal Fluid; Culture Techniques; Dizocilpine Maleate; Elec | 2003 |
Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Infarction; Brain Ischemia; Disease Models, Animal; Edema | 2005 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
Spectroscopic imaging of circular voxels with a two-dimensional Fourier-series window technique.
Topics: Adenosine Triphosphate; Animals; Artifacts; Brain Ischemia; Diphosphates; Dogs; Female; Humans; Hydr | 1994 |
A one-dimensional (proton and phosphorus) and two-dimensional (proton) in vivo NMR spectroscopic study of reversible global cerebral ischemia.
Topics: Animals; Brain Ischemia; Hydrogen; Magnetic Resonance Spectroscopy; Male; Phosphorus Isotopes; Prose | 1996 |
Dynamic changes in water ADC, energy metabolism, extracellular space volume, and tortuosity in neonatal rat brain during global ischemia.
Topics: Animals; Animals, Newborn; Body Water; Brain; Brain Ischemia; Diffusion; Energy Metabolism; Extracel | 1996 |
Comparison of cerebral blood flow measured by laser-Doppler flowmetry and hydrogen clearance in cats after cerebral insult and hypervolemic hemodilution.
Topics: Animals; Blood Volume; Brain Ischemia; Cats; Cerebrovascular Circulation; Cisterna Magna; Creatinine | 1996 |
Protective effects of extracellular acidosis and blockade of sodium/hydrogen ion exchange during recovery from metabolic inhibition in neuronal tissue culture.
Topics: Acidosis; Amiloride; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; | 1996 |
Intraoperative on-line monitoring of cerebral pH by microdialysis in neurosurgical procedures.
Topics: Adult; Aged; Brain; Brain Edema; Brain Ischemia; Computers; Heart Arrest, Induced; Humans; Hydrogen; | 1998 |
Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats.
Topics: Acetates; Amino Acids; Animals; Arteries; Blood Pressure; Brain; Brain Ischemia; Carbon Isotopes; Cy | 1998 |
Brain tissue PO(2), PCO(2), and pH during cerebral vasospasm.
Topics: Aged; Brain; Brain Ischemia; Carbon Dioxide; Female; Humans; Hydrogen; Hydrogen-Ion Concentration; I | 2000 |
Investigation of stroke in sickle cell disease by 1H nuclear magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Aspartic Acid; Atrophy; Brain; Brain Ischemia; Cerebral Infa | 1992 |
Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Chemistry; Brain Ischemia; Cerebral Infarction; | 1992 |
Dependence of cerebral energy phosphate and evoked potential recovery on end-ischemic pH.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Differential Threshold; Dogs; Energy Me | 1991 |
1H-NMR studies on water structures in the rat brain tissues with cerebral tumour or ischaemia.
Topics: Animals; Body Water; Brain; Brain Ischemia; Brain Neoplasms; Carotid Arteries; Constriction, Patholo | 1990 |
A rapid redistribution of hydrogen ions is associated with depolarization and repolarization subsequent to cerebral ischemia reperfusion.
Topics: Acidosis; Animals; Brain Chemistry; Brain Ischemia; Carbon Dioxide; Electrophysiology; Glucose; Hydr | 1990 |
The novel dihydronaphthyridine Ca2+ channel blocker CI-951 improves CBF, brain pHi, and EEG recovery in focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Chemical Phenomena; Chemistry; Death; E | 1990 |
Acid homeostasis following partial ischemia in neonatal brain measured in vivo by 31P and 1H nuclear magnetic resonance spectroscopy.
Topics: Acidosis, Respiratory; Acids; Animals; Animals, Newborn; Brain Ischemia; Energy Metabolism; Homeosta | 1990 |
Cerebral metabolite dynamics during temporary complete ischemia in rats monitored by time-shared 1H and 31P NMR spectroscopy.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Hydrogen; Hydrogen-Ion Conc | 1990 |
Carbonic acid buffer changes during complete brain ischemia.
Topics: Animals; Bicarbonates; Brain; Brain Ischemia; Buffers; Carbon Dioxide; Carbonates; Carbonic Acid; Hy | 1986 |
Global cerebral ischemia and intracellular pH during hyperglycemia and hypoglycemia in cats.
Topics: Animals; Brain; Brain Ischemia; Cats; Female; Hydrogen; Hydrogen-Ion Concentration; Hyperglycemia; H | 1988 |
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. III. Changes following ischaemia.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Gerbillinae; Hydroge | 1988 |
Pathophysiological investigation of experimental cerebral ischaemia using in vivo 31P-NMR spectroscopy and 1H-MRI.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Edema; Brain Ischemia; Carotid Artery Diseases; C | 1988 |
Evidence against major compartmentalization of H+ in ischemic rat brain tissue.
Topics: Animals; Brain; Brain Ischemia; Hydrogen; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Magneti | 1988 |
Metabolic changes during experimental cerebral ischemia in hyperglycemic rats, observed by 31P and 1H magnetic resonance spectroscopy.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Animals; Brain Ischemia; Hydrogen; Hydrogen-Ion Concentrat | 1988 |
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. I. Methodology.
Topics: Acute Disease; Animals; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Gerbillinae; | 1987 |
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. II. Changes during ischaemia.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Gerbi | 1987 |
Effects of increased ICP on brain phosphocreatine and lactate determined by simultaneous 1H and 31P NMR spectroscopy.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cats; Female; Hydrogen; Hydrogen-Ion Concentration; | 1987 |
Simultaneous 31P- and 1H-nuclear magnetic resonance studies of hypoxia and ischemia in the cat brain.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cats; Electroencephalography; Hydrogen; Hypo | 1987 |
pH, K+, and PO2 of the extracellular space during ischaemia of primate cerebral cortex.
Topics: Animals; Biological Availability; Brain Ischemia; Cerebral Cortex; Extracellular Space; Female; Home | 1987 |
Measurement of ischemic changes in cerebral blood flow by the hydrogen clearance technique and brain cortical temperature. Influence of flunarizine.
Topics: Animals; Body Temperature; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Cinnarizine | 1986 |
Heterogeneous distribution of hydrogen and bicarbonate ions during complete brain ischemia.
Topics: Animals; Bicarbonates; Brain Ischemia; Hydrogen; Mammals; Tissue Distribution | 1985 |