hydrogen has been researched along with Brain Injuries in 27 studies
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrogen gas significantly alleviated brain edema and blood-brain barrier disruption, reduced apoptosis, and improved neurologic function at 24 hrs but not 72 hrs after subarachnoid hemorrhage." | 7.78 | Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. ( Chen, C; Hu, Q; Suzuki, H; Zhan, Y; Zhang, JH; Zhi, X, 2012) |
| " In contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement of neurology outcome was not obvious." | 7.78 | Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. ( Ma, CY; Shi, JX; Sun, XJ; You, WC; Zhou, ML; Zhu, L; Zhuang, Z, 2012) |
| "This study aimed to investigate the effects of hydrogen on fetal brain injury during maternal hypoxia." | 7.77 | Protective effects of hydrogen on fetal brain injury during maternal hypoxia. ( Chen, C; Chen, O; Liu, W; Tang, J; Wu, B; Zhang, JH, 2011) |
| "Hydrogen has been reported to alleviate early brain injury (EBI) through oxidative stress injury, reactive oxygen species (ROS), and autophagy." | 5.62 | Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage. ( Dai, W; Jiang, B; Li, Y; Mao, D; Wu, A; Wu, H, 2021) |
| "Hydrogen gas is a new medical gas that exerts anti-inflammation, antioxidation, and anti-apoptotic effects and can effectively protect septic mice." | 5.62 | Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice. ( Chen, H; Mao, X; Wang, G; Wang, Y; Xie, K; Yin, L, 2021) |
| "Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated blood-brain barrier disruption, and improved neurobehavioral function." | 5.39 | Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. ( Lekic, T; Ma, Q; Manaenko, A; Tang, J; Zhang, JH, 2013) |
| "To investigate the effect of hydrogen-rich water on cerebral edema and aquaporin 1 (AQP1) expression in rats with traumatic brain injury (TBI)." | 3.83 | [Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury]. ( Chen, X; Liu, Y; Wang, D; Yuan, J; Zhang, H, 2016) |
| "Hydrogen gas significantly alleviated brain edema and blood-brain barrier disruption, reduced apoptosis, and improved neurologic function at 24 hrs but not 72 hrs after subarachnoid hemorrhage." | 3.78 | Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. ( Chen, C; Hu, Q; Suzuki, H; Zhan, Y; Zhang, JH; Zhi, X, 2012) |
| " In contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement of neurology outcome was not obvious." | 3.78 | Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. ( Ma, CY; Shi, JX; Sun, XJ; You, WC; Zhou, ML; Zhu, L; Zhuang, Z, 2012) |
| "This study aimed to investigate the effects of hydrogen on fetal brain injury during maternal hypoxia." | 3.77 | Protective effects of hydrogen on fetal brain injury during maternal hypoxia. ( Chen, C; Chen, O; Liu, W; Tang, J; Wu, B; Zhang, JH, 2011) |
| "Hydrogen has been reported to alleviate early brain injury (EBI) through oxidative stress injury, reactive oxygen species (ROS), and autophagy." | 1.62 | Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage. ( Dai, W; Jiang, B; Li, Y; Mao, D; Wu, A; Wu, H, 2021) |
| "Hydrogen gas is a new medical gas that exerts anti-inflammation, antioxidation, and anti-apoptotic effects and can effectively protect septic mice." | 1.62 | Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice. ( Chen, H; Mao, X; Wang, G; Wang, Y; Xie, K; Yin, L, 2021) |
| "Hydrogen-rich saline treatment dose dependently improved survival and neurological function after cardiac arrest/resuscitation." | 1.40 | Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats. ( Chen, HG; Dong, HL; Han, HZ; Huang, Y; Huo, TT; Liu, XN; Lu, ZH; Nie, H; Sun, L; Xie, KL; Xiong, LZ; Zeng, Y, 2014) |
| "Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated blood-brain barrier disruption, and improved neurobehavioral function." | 1.39 | Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. ( Lekic, T; Ma, Q; Manaenko, A; Tang, J; Zhang, JH, 2013) |
| "Hydrogen gas (H(2)) has been considered as a novel antioxidant to selectively reduce the toxic reactive oxygen species (ROS) such as hydroxyl radical (•OH) without affecting the other signal ROS." | 1.38 | Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. ( Fei, Z; Ji, X; Liu, W; Qu, Y; Tian, Y; Xie, K, 2012) |
| "Hydrogen treatment was given by exposure to 2% H(2) from 5 min to 5h after sham or TBI operation, respectively." | 1.36 | Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. ( Chao, X; Chen, T; Fei, Z; Ji, X; Liu, W; Qu, Y; Xie, K; Zhou, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 21 (77.78) | 24.3611 |
| 2020's | 4 (14.81) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, B | 1 |
| Li, Y | 4 |
| Dai, W | 1 |
| Wu, A | 1 |
| Wu, H | 3 |
| Mao, D | 1 |
| Ma, L | 1 |
| Tian, S | 1 |
| Zhang, HL | 1 |
| Wang, JY | 1 |
| Wang, JW | 1 |
| Yan, HL | 1 |
| Hu, XG | 1 |
| Shao, Q | 1 |
| Guo, JM | 1 |
| Xie, K | 4 |
| Wang, Y | 2 |
| Yin, L | 1 |
| Chen, H | 2 |
| Mao, X | 2 |
| Wang, G | 2 |
| Kumagai, K | 1 |
| Toyooka, T | 1 |
| Takeuchi, S | 1 |
| Otani, N | 1 |
| Wada, K | 1 |
| Tomiyama, A | 1 |
| Mori, K | 1 |
| Chen, K | 1 |
| Wang, N | 1 |
| Diao, Y | 1 |
| Dong, W | 1 |
| Sun, Y | 1 |
| Liu, L | 2 |
| Wu, X | 1 |
| Chen, X | 2 |
| Wang, D | 2 |
| Liu, Y | 2 |
| Yuan, J | 2 |
| Zhang, H | 2 |
| Wu, G | 1 |
| Chen, Z | 1 |
| Wang, P | 1 |
| Zhao, M | 1 |
| Fujino, M | 1 |
| Zhang, C | 1 |
| Zhou, W | 1 |
| Hirano, SI | 1 |
| Li, XK | 1 |
| Zhao, L | 1 |
| Huo, TT | 1 |
| Zeng, Y | 1 |
| Liu, XN | 1 |
| Sun, L | 1 |
| Han, HZ | 1 |
| Chen, HG | 1 |
| Lu, ZH | 1 |
| Huang, Y | 1 |
| Nie, H | 1 |
| Dong, HL | 1 |
| Xie, KL | 1 |
| Xiong, LZ | 1 |
| Dohi, K | 1 |
| Kraemer, BC | 1 |
| Erickson, MA | 1 |
| McMillan, PJ | 1 |
| Kovac, A | 1 |
| Flachbartova, Z | 1 |
| Hansen, KM | 1 |
| Shah, GN | 1 |
| Sheibani, N | 1 |
| Salameh, T | 1 |
| Banks, WA | 1 |
| Dong, X | 1 |
| Yu, Y | 2 |
| Shao, A | 1 |
| Hong, Y | 1 |
| Tu, S | 1 |
| Sun, X | 3 |
| Wu, Q | 1 |
| Zhao, Q | 1 |
| Zhang, J | 1 |
| Sheng, J | 1 |
| Imai, K | 1 |
| Kotani, T | 1 |
| Tsuda, H | 1 |
| Mano, Y | 1 |
| Nakano, T | 1 |
| Ushida, T | 1 |
| Li, H | 1 |
| Miki, R | 1 |
| Sumigama, S | 1 |
| Iwase, A | 1 |
| Hirakawa, A | 1 |
| Ohno, K | 1 |
| Toyokuni, S | 1 |
| Takeuchi, H | 1 |
| Mizuno, T | 1 |
| Suzumura, A | 1 |
| Kikkawa, F | 1 |
| Tian, R | 1 |
| Hou, Z | 2 |
| Hao, S | 2 |
| Wu, W | 1 |
| Tao, X | 1 |
| Lu, T | 1 |
| Liu, B | 2 |
| Ji, X | 2 |
| Liu, W | 4 |
| Qu, Y | 2 |
| Chao, X | 1 |
| Chen, T | 1 |
| Zhou, J | 1 |
| Fei, Z | 2 |
| Shen, L | 1 |
| Wang, J | 1 |
| Liu, K | 1 |
| Wang, C | 2 |
| Sun, Q | 1 |
| Jing, H | 1 |
| Chen, O | 1 |
| Chen, C | 2 |
| Wu, B | 1 |
| Tang, J | 2 |
| Zhang, JH | 3 |
| Zhan, Y | 1 |
| Suzuki, H | 1 |
| Hu, Q | 1 |
| Zhi, X | 1 |
| Hardeland, R | 1 |
| Tian, Y | 1 |
| Zhuang, Z | 1 |
| Zhou, ML | 1 |
| You, WC | 1 |
| Zhu, L | 1 |
| Ma, CY | 1 |
| Sun, XJ | 1 |
| Shi, JX | 1 |
| Luo, W | 1 |
| Zhang, Y | 1 |
| Xu, F | 1 |
| Wang, Z | 1 |
| Wang, W | 2 |
| Tian, L | 1 |
| Wang, X | 1 |
| Xia, F | 2 |
| Li, L | 1 |
| Li, J | 2 |
| Zhang, Z | 2 |
| Ren, J | 1 |
| Manaenko, A | 1 |
| Lekic, T | 1 |
| Ma, Q | 1 |
| Jorgensen, PB | 1 |
| Karimi-Nejad, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Perioperative Hydrogen Inhalation on Post-operative Pain and Inflammation Cytokines[NCT05476575] | 32 participants (Anticipated) | Interventional | 2021-10-28 | Recruiting | |||
| Evaluation of the Daily Intake of 0.5 L of Water Saturated With Molecular Hydrogen for 21 Days in COVID-19 Patients Treated in Ambulatory Care. Double-blind, Randomized, Comparative Study[NCT04716985] | 700 participants (Actual) | Interventional | 2021-01-22 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
27 other studies available for hydrogen and Brain Injuries
| Article | Year |
|---|---|
Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Autophagy; Brain; Brain Injuries; Hydrogen; Mice; Mice, Inbred C57BL; Neuroprote | 2021 |
Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage.
Topics: Animals; Brain; Brain Injuries; Electromagnetic Phenomena; Hydrogen; Male; Oxidative Stress; Rats; T | 2023 |
Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.
Topics: Animals; Brain Injuries; Disease Models, Animal; DNA-Binding Proteins; High Mobility Group Proteins; | 2021 |
Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
Topics: Administration, Inhalation; Animals; Blood Pressure; Brain; Brain Edema; Brain Injuries; Cell Death; | 2020 |
Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Cardiopulmonary Bypass; Endothelial Cells; Glycogen Synth | 2017 |
[Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury].
Topics: Animals; Aquaporin 1; Blotting, Western; Brain; Brain Edema; Brain Injuries; Brain Injuries, Traumat | 2016 |
Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
Topics: Administration, Inhalation; Animals; Apoptosis; Brain Injuries; Female; Gene Expression Regulation; | 2019 |
Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats.
Topics: Administration, Intravenous; Animals; Antioxidants; Apoptosis; Biomarkers; Blood-Brain Barrier; Brai | 2014 |
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Injuries; Cytokines; Drinking Water; Gene Expressio | 2014 |
Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis.
Topics: Administration, Inhalation; Animals; Apoptosis; Brain Injuries; Cecum; Conditioning, Psychological; | 2014 |
Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome.
Topics: Animals; Antioxidants; Apoptosis; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Cytokines; Do | 2016 |
Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Injuries; Cells, Cultured; Cytokines; Female; Hydrog | 2016 |
Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Blood-Brain Barrier; Brain Injuries; Bra | 2016 |
[Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury].
Topics: Animals; Brain; Brain Injuries; Hydrogen; Male; NF-E2-Related Factor 2; Oxidative Stress; Random All | 2015 |
Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Antioxidants; Blood-Brain Barrier; Brain; | 2010 |
Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest.
Topics: Animals; Apoptosis; Brain Injuries; Caspase 3; Circulatory Arrest, Deep Hypothermia Induced; Hydroge | 2011 |
Protective effects of hydrogen on fetal brain injury during maternal hypoxia.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Animals, Newborn; Body Weight; Brain Injuries; | 2011 |
Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats.
Topics: Administration, Inhalation; Animals; Antioxidants; Apoptosis; Blood-Brain Barrier; Brain; Brain Chem | 2012 |
Hydrogen therapy: a future option in critical care?
Topics: Animals; Antioxidants; Brain Injuries; Hydrogen; Male; Oxidative Stress; Subarachnoid Hemorrhage | 2012 |
Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Hyd | 2012 |
Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits.
Topics: Analysis of Variance; Animals; Brain Edema; Brain Injuries; Caspase 12; Caspase 3; Cell Death; Cereb | 2012 |
Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury.
Topics: Animals; Antioxidants; Brain Injuries; Brain-Derived Neurotrophic Factor; Cognition Disorders; Drug | 2012 |
Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning.
Topics: Animals; Antioxidants; Brain Chemistry; Brain Injuries; Carbon Monoxide Poisoning; Cognition; Copper | 2013 |
Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning.
Topics: Acute Disease; Animals; Brain Injuries; Carbon Monoxide Poisoning; Hydrogen; Male; Neuroprotective A | 2012 |
Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Blood-Brain Barrier; Blotting, Western; B | 2013 |
Brain death. Cerebral appearance of inhaled hydrogen in the diagnosis of cerebral circulatry arrest.
Topics: Adult; Brain Chemistry; Brain Death; Brain Injuries; Brain Neoplasms; Cerebral Angiography; Cerebral | 1974 |
[Prevention and treatment of infectious lung complications in acute and subacute brain injuries. Early breathing exercises; pathogenic contamination of the respiratory tract; antibiotic therapy].
Topics: Anti-Bacterial Agents; Brain Injuries; Breathing Exercises; Carbon Dioxide; Cerebrovascular Circulat | 1974 |