Page last updated: 2024-10-18

hydrogen and Brain Edema

hydrogen has been researched along with Brain Edema in 18 studies

Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

ExcerptRelevanceReference
" In contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement of neurology outcome was not obvious."7.78Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. ( Ma, CY; Shi, JX; Sun, XJ; You, WC; Zhou, ML; Zhu, L; Zhuang, Z, 2012)
"Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated blood-brain barrier disruption, and improved neurobehavioral function."5.39Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. ( Lekic, T; Ma, Q; Manaenko, A; Tang, J; Zhang, JH, 2013)
"To investigate the effect of hydrogen-rich water on cerebral edema and aquaporin 1 (AQP1) expression in rats with traumatic brain injury (TBI)."3.83[Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury]. ( Chen, X; Liu, Y; Wang, D; Yuan, J; Zhang, H, 2016)
" In contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement of neurology outcome was not obvious."3.78Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. ( Ma, CY; Shi, JX; Sun, XJ; You, WC; Zhou, ML; Zhu, L; Zhuang, Z, 2012)
"The hydrogen gas treatment had no significant effect on vital signs or CBF values."1.39The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion. ( Fujita, M; Kobayashi, H; Nagatani, K; Nawashiro, H; Otani, N; Shima, K; Tachibana, S; Takeuchi, S; Wada, K, 2013)
"Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated blood-brain barrier disruption, and improved neurobehavioral function."1.39Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. ( Lekic, T; Ma, Q; Manaenko, A; Tang, J; Zhang, JH, 2013)
"Hydrogen gas (H(2)) has been considered as a novel antioxidant to selectively reduce the toxic reactive oxygen species (ROS) such as hydroxyl radical (•OH) without affecting the other signal ROS."1.38Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. ( Fei, Z; Ji, X; Liu, W; Qu, Y; Tian, Y; Xie, K, 2012)
"Hydrogen treatment was given by exposure to 2% H(2) from 5 min to 5h after sham or TBI operation, respectively."1.36Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. ( Chao, X; Chen, T; Fei, Z; Ji, X; Liu, W; Qu, Y; Xie, K; Zhou, J, 2010)
"Choline peak area was increased in tumor, creatine and N-acetyl aspartate were decreased in edema and tumor compared with unaffected brain tissue."1.311H chemical shift imaging characterization of human brain tumor and edema. ( Oudkerk, M; Sijens, PE, 2002)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19904 (22.22)18.7374
1990's2 (11.11)18.2507
2000's1 (5.56)29.6817
2010's9 (50.00)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Li, TT1
Yang, WC1
Wang, YZ1
Sun, T1
Cao, HL1
Chen, JF1
Li, WZ1
Kumagai, K1
Toyooka, T1
Takeuchi, S2
Otani, N2
Wada, K2
Tomiyama, A1
Mori, K1
Chen, X1
Wang, D1
Liu, Y1
Yuan, J1
Zhang, H1
Nagatani, K1
Kobayashi, H1
Fujita, M1
Nawashiro, H1
Tachibana, S1
Shima, K1
Dohi, K1
Kraemer, BC1
Erickson, MA1
McMillan, PJ1
Kovac, A1
Flachbartova, Z1
Hansen, KM1
Shah, GN1
Sheibani, N1
Salameh, T1
Banks, WA1
Shao, A1
Wu, H1
Hong, Y1
Tu, S1
Sun, X1
Wu, Q1
Zhao, Q1
Zhang, J1
Sheng, J1
Ji, X2
Liu, W3
Xie, K2
Qu, Y2
Chao, X1
Chen, T1
Zhou, J1
Fei, Z2
Manaenko, A2
Lekic, T2
Ma, Q2
Ostrowski, RP1
Zhang, JH2
Tang, J2
Tian, Y1
Zhuang, Z1
Zhou, ML1
You, WC1
Zhu, L1
Ma, CY1
Sun, XJ1
Shi, JX1
Sijens, PE1
Oudkerk, M1
Mendelowitsch, A1
Sekhar, LN1
Caputy, AJ1
Shuaib, A1
Iwama, T1
Yamada, H1
Era, S1
Sogami, M1
Andoh, T1
Sakai, N1
Kato, K1
Kuwata, K1
Watari, H1
Higuchi, T1
Naruse, S2
Horikawa, Y1
Tanaka, C1
Ebisu, T1
Yamamoto, K1
Hirakawa, K2
Balouet, G1
Barthelemy, L1
Parc, J1
Michaud, A1
Le Chuiton, J1
Leroy, JP1
Meyer, JS1
Fukuuchi, Y1
Kanda, T1
Shimarzu, K1
Hashi, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Daily Intake of 0.5 L of Water Saturated With Molecular Hydrogen for 21 Days in COVID-19 Patients Treated in Ambulatory Care. Double-blind, Randomized, Comparative Study[NCT04716985]700 participants (Actual)Interventional2021-01-22Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

18 other studies available for hydrogen and Brain Edema

ArticleYear
Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats.
    Brain research, 2020, 03-01, Volume: 1730

    Topics: Animals; Apoptosis; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries, Traum

2020
Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
    Scientific reports, 2020, 07-23, Volume: 10, Issue:1

    Topics: Administration, Inhalation; Animals; Blood Pressure; Brain; Brain Edema; Brain Injuries; Cell Death;

2020
[Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury].
    Zhonghua wei zhong bing ji jiu yi xue, 2016, Volume: 28, Issue:5

    Topics: Animals; Aquaporin 1; Blotting, Western; Brain; Brain Edema; Brain Injuries; Brain Injuries, Traumat

2016
The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion.
    Acta neurochirurgica. Supplement, 2013, Volume: 118

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Analysis of Variance; Animals; Arterial Occlusive Diseases; Brain Edema

2013
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Injuries; Cytokines; Drinking Water; Gene Expressio

2014
Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome.
    Molecular neurobiology, 2016, Volume: 53, Issue:5

    Topics: Animals; Antioxidants; Apoptosis; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Cytokines; Do

2016
Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress.
    Brain research, 2010, Oct-01, Volume: 1354

    Topics: Administration, Inhalation; Analysis of Variance; Animals; Antioxidants; Blood-Brain Barrier; Brain;

2010
Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage.
    Acta neurochirurgica. Supplement, 2011, Volume: 111

    Topics: Administration, Inhalation; Analysis of Variance; Animals; Brain; Brain Edema; Cerebral Hemorrhage;

2011
Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
    The Journal of surgical research, 2012, Volume: 178, Issue:1

    Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Hyd

2012
Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits.
    BMC neuroscience, 2012, May-15, Volume: 13

    Topics: Analysis of Variance; Animals; Brain Edema; Brain Injuries; Caspase 12; Caspase 3; Cell Death; Cereb

2012
Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice.
    Critical care medicine, 2013, Volume: 41, Issue:5

    Topics: Administration, Inhalation; Analysis of Variance; Animals; Blood-Brain Barrier; Blotting, Western; B

2013
1H chemical shift imaging characterization of human brain tumor and edema.
    European radiology, 2002, Volume: 12, Issue:8

    Topics: Aspartic Acid; Brain Edema; Brain Neoplasms; Choline; Creatine; Humans; Hydrogen; Magnetic Resonance

2002
Intraoperative on-line monitoring of cerebral pH by microdialysis in neurosurgical procedures.
    Neurological research, 1998, Volume: 20, Issue:2

    Topics: Adult; Aged; Brain; Brain Edema; Brain Ischemia; Computers; Heart Arrest, Induced; Humans; Hydrogen;

1998
Proton nuclear magnetic resonance studies on water structure in peritumoral edematous brain tissue.
    Magnetic resonance in medicine, 1992, Volume: 24, Issue:1

    Topics: Animals; Astrocytoma; Blood-Brain Barrier; Body Water; Brain Chemistry; Brain Edema; Brain Neoplasms

1992
Pathophysiological investigation of experimental cerebral ischaemia using in vivo 31P-NMR spectroscopy and 1H-MRI.
    Acta neurochirurgica. Supplementum, 1988, Volume: 43

    Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Edema; Brain Ischemia; Carotid Artery Diseases; C

1988
[Methods of imaging brain metabolism and function--b. Magnetic resonance imaging in brain metabolism and function].
    Nihon rinsho. Japanese journal of clinical medicine, 1987, Volume: 45, Issue:9

    Topics: Brain; Brain Edema; Brain Neoplasms; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonanc

1987
[Subclinical lesions in animals subjected to experimental deep diving].
    Pathologie-biologie, 1974, Volume: 22, Issue:1

    Topics: Animals; Brain; Brain Edema; Decompression Sickness; Diving; Guinea Pigs; Helium; Hemorrhage; Hydrog

1974
Regional cerebral blood flow measured by intracarotid injection of hydrogen. Comparison of regional vasomotor capacitance from cerebral infarction versus compression.
    Neurology, 1972, Volume: 22, Issue:6

    Topics: Animals; Brain Edema; Carbon Dioxide; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascula

1972