hydrogen has been researched along with Brain Edema in 18 studies
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement of neurology outcome was not obvious." | 7.78 | Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. ( Ma, CY; Shi, JX; Sun, XJ; You, WC; Zhou, ML; Zhu, L; Zhuang, Z, 2012) |
| "Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated blood-brain barrier disruption, and improved neurobehavioral function." | 5.39 | Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. ( Lekic, T; Ma, Q; Manaenko, A; Tang, J; Zhang, JH, 2013) |
| "To investigate the effect of hydrogen-rich water on cerebral edema and aquaporin 1 (AQP1) expression in rats with traumatic brain injury (TBI)." | 3.83 | [Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury]. ( Chen, X; Liu, Y; Wang, D; Yuan, J; Zhang, H, 2016) |
| " In contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement of neurology outcome was not obvious." | 3.78 | Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. ( Ma, CY; Shi, JX; Sun, XJ; You, WC; Zhou, ML; Zhu, L; Zhuang, Z, 2012) |
| "The hydrogen gas treatment had no significant effect on vital signs or CBF values." | 1.39 | The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion. ( Fujita, M; Kobayashi, H; Nagatani, K; Nawashiro, H; Otani, N; Shima, K; Tachibana, S; Takeuchi, S; Wada, K, 2013) |
| "Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated blood-brain barrier disruption, and improved neurobehavioral function." | 1.39 | Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. ( Lekic, T; Ma, Q; Manaenko, A; Tang, J; Zhang, JH, 2013) |
| "Hydrogen gas (H(2)) has been considered as a novel antioxidant to selectively reduce the toxic reactive oxygen species (ROS) such as hydroxyl radical (•OH) without affecting the other signal ROS." | 1.38 | Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. ( Fei, Z; Ji, X; Liu, W; Qu, Y; Tian, Y; Xie, K, 2012) |
| "Hydrogen treatment was given by exposure to 2% H(2) from 5 min to 5h after sham or TBI operation, respectively." | 1.36 | Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. ( Chao, X; Chen, T; Fei, Z; Ji, X; Liu, W; Qu, Y; Xie, K; Zhou, J, 2010) |
| "Choline peak area was increased in tumor, creatine and N-acetyl aspartate were decreased in edema and tumor compared with unaffected brain tissue." | 1.31 | 1H chemical shift imaging characterization of human brain tumor and edema. ( Oudkerk, M; Sijens, PE, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Li, TT | 1 |
| Yang, WC | 1 |
| Wang, YZ | 1 |
| Sun, T | 1 |
| Cao, HL | 1 |
| Chen, JF | 1 |
| Li, WZ | 1 |
| Kumagai, K | 1 |
| Toyooka, T | 1 |
| Takeuchi, S | 2 |
| Otani, N | 2 |
| Wada, K | 2 |
| Tomiyama, A | 1 |
| Mori, K | 1 |
| Chen, X | 1 |
| Wang, D | 1 |
| Liu, Y | 1 |
| Yuan, J | 1 |
| Zhang, H | 1 |
| Nagatani, K | 1 |
| Kobayashi, H | 1 |
| Fujita, M | 1 |
| Nawashiro, H | 1 |
| Tachibana, S | 1 |
| Shima, K | 1 |
| Dohi, K | 1 |
| Kraemer, BC | 1 |
| Erickson, MA | 1 |
| McMillan, PJ | 1 |
| Kovac, A | 1 |
| Flachbartova, Z | 1 |
| Hansen, KM | 1 |
| Shah, GN | 1 |
| Sheibani, N | 1 |
| Salameh, T | 1 |
| Banks, WA | 1 |
| Shao, A | 1 |
| Wu, H | 1 |
| Hong, Y | 1 |
| Tu, S | 1 |
| Sun, X | 1 |
| Wu, Q | 1 |
| Zhao, Q | 1 |
| Zhang, J | 1 |
| Sheng, J | 1 |
| Ji, X | 2 |
| Liu, W | 3 |
| Xie, K | 2 |
| Qu, Y | 2 |
| Chao, X | 1 |
| Chen, T | 1 |
| Zhou, J | 1 |
| Fei, Z | 2 |
| Manaenko, A | 2 |
| Lekic, T | 2 |
| Ma, Q | 2 |
| Ostrowski, RP | 1 |
| Zhang, JH | 2 |
| Tang, J | 2 |
| Tian, Y | 1 |
| Zhuang, Z | 1 |
| Zhou, ML | 1 |
| You, WC | 1 |
| Zhu, L | 1 |
| Ma, CY | 1 |
| Sun, XJ | 1 |
| Shi, JX | 1 |
| Sijens, PE | 1 |
| Oudkerk, M | 1 |
| Mendelowitsch, A | 1 |
| Sekhar, LN | 1 |
| Caputy, AJ | 1 |
| Shuaib, A | 1 |
| Iwama, T | 1 |
| Yamada, H | 1 |
| Era, S | 1 |
| Sogami, M | 1 |
| Andoh, T | 1 |
| Sakai, N | 1 |
| Kato, K | 1 |
| Kuwata, K | 1 |
| Watari, H | 1 |
| Higuchi, T | 1 |
| Naruse, S | 2 |
| Horikawa, Y | 1 |
| Tanaka, C | 1 |
| Ebisu, T | 1 |
| Yamamoto, K | 1 |
| Hirakawa, K | 2 |
| Balouet, G | 1 |
| Barthelemy, L | 1 |
| Parc, J | 1 |
| Michaud, A | 1 |
| Le Chuiton, J | 1 |
| Leroy, JP | 1 |
| Meyer, JS | 1 |
| Fukuuchi, Y | 1 |
| Kanda, T | 1 |
| Shimarzu, K | 1 |
| Hashi, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Daily Intake of 0.5 L of Water Saturated With Molecular Hydrogen for 21 Days in COVID-19 Patients Treated in Ambulatory Care. Double-blind, Randomized, Comparative Study[NCT04716985] | 700 participants (Actual) | Interventional | 2021-01-22 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for hydrogen and Brain Edema
| Article | Year |
|---|---|
Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats.
Topics: Animals; Apoptosis; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries, Traum | 2020 |
Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
Topics: Administration, Inhalation; Animals; Blood Pressure; Brain; Brain Edema; Brain Injuries; Cell Death; | 2020 |
[Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury].
Topics: Animals; Aquaporin 1; Blotting, Western; Brain; Brain Edema; Brain Injuries; Brain Injuries, Traumat | 2016 |
The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Analysis of Variance; Animals; Arterial Occlusive Diseases; Brain Edema | 2013 |
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Injuries; Cytokines; Drinking Water; Gene Expressio | 2014 |
Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome.
Topics: Animals; Antioxidants; Apoptosis; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Cytokines; Do | 2016 |
Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Antioxidants; Blood-Brain Barrier; Brain; | 2010 |
Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Brain; Brain Edema; Cerebral Hemorrhage; | 2011 |
Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Hyd | 2012 |
Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits.
Topics: Analysis of Variance; Animals; Brain Edema; Brain Injuries; Caspase 12; Caspase 3; Cell Death; Cereb | 2012 |
Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Blood-Brain Barrier; Blotting, Western; B | 2013 |
1H chemical shift imaging characterization of human brain tumor and edema.
Topics: Aspartic Acid; Brain Edema; Brain Neoplasms; Choline; Creatine; Humans; Hydrogen; Magnetic Resonance | 2002 |
Intraoperative on-line monitoring of cerebral pH by microdialysis in neurosurgical procedures.
Topics: Adult; Aged; Brain; Brain Edema; Brain Ischemia; Computers; Heart Arrest, Induced; Humans; Hydrogen; | 1998 |
Proton nuclear magnetic resonance studies on water structure in peritumoral edematous brain tissue.
Topics: Animals; Astrocytoma; Blood-Brain Barrier; Body Water; Brain Chemistry; Brain Edema; Brain Neoplasms | 1992 |
Pathophysiological investigation of experimental cerebral ischaemia using in vivo 31P-NMR spectroscopy and 1H-MRI.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Edema; Brain Ischemia; Carotid Artery Diseases; C | 1988 |
[Methods of imaging brain metabolism and function--b. Magnetic resonance imaging in brain metabolism and function].
Topics: Brain; Brain Edema; Brain Neoplasms; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonanc | 1987 |
[Subclinical lesions in animals subjected to experimental deep diving].
Topics: Animals; Brain; Brain Edema; Decompression Sickness; Diving; Guinea Pigs; Helium; Hemorrhage; Hydrog | 1974 |
Regional cerebral blood flow measured by intracarotid injection of hydrogen. Comparison of regional vasomotor capacitance from cerebral infarction versus compression.
Topics: Animals; Brain Edema; Carbon Dioxide; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascula | 1972 |