hydrocortisone-valerate and Dermatitis--Atopic

Topics: Administration, Topical; Anti-Inflammatory Agents; Child; Child, Preschool; Dermatitis, Atopic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Resistance; Female; Follow-Up Studies; Humans; Hydrocortisone; Male; Mometasone Furoate; Pregnadienediols; Treatment Outcome

Evaluations of the comparative efficacy and safety of hydrocortisone valerate 0.2% ointment were made in six double-blind, multicenter trials involving a total of 485 patients, 209 with atopic dermatitis and 276 with plaque psoriasis. The vasoconstrictor activity of hydrocortisone valerate 0.2% ointment was also assessed in normal subjects. Hydrocortisone valerate 0.2% ointment displayed therapeutic effects within three days. In terms of global evaluations of efficacy, hydrocortisone valerate was more effective than vehicle and was comparable to other intermediate or moderate potency corticosteroid ointments. The vasoconstrictor activity of hydrocortisone valerate 0.2% ointment was greater than that of other moderate potency ointments.

Topics: Adrenal Cortex Hormones; Adult; Clinical Trials as Topic; Dermatitis, Atopic; Double-Blind Method; Drug Evaluation; Female; Humans; Hydrocortisone; Male; Middle Aged; Ointments; Psoriasis; Vasoconstriction

Evaluations of the comparative efficacy and safety of a newly developed emollient ointment formulation of hydrocortisone valerate 0.2 percent were made in two double-blind, multicenter trials involving 145 patients with atopic dermatitis. Data are presented which indicate that hydrocortisone valerate 0.2 percent ointment is effective in the treatment of mild to moderate atopic dermatitis, has efficacy comparable to that of other intermediate potency corticosteroid ointments, and, moreover, that it is readily accepted by patients.

Topics: Betamethasone Valerate; Clinical Trials as Topic; Dermatitis, Atopic; Fluocinolone Acetonide; Humans; Hydrocortisone; Triamcinolone Acetonide

Therapy with systemic corticosteroids, despite attendant serious risks, is mandatory in diseases such as pemphigus, acute disseminated lupus erythematosus and some cases of exfoliative dermatitis that are ordinarily fatal, for in such cases life may be prolonged and the patients made comfortable. If no contraindications exist, therapy with corticosteroids is desirable, for diseases of short duration-contact dermatitis, serum sickness reactions and drug eruptions of all kinds-provided the causative factors have been removed and the reactions are causing severe distress.On the basis of encouraging reports in the literature corticosteroid therapy may be instituted with justification for a group of unrelated, intractable and discomforting diseases such as maddening pruritus ani, sclerema neonatorum, dermatomyositis, certain cases of sarcoidosis, berylliosis, Behcet's syndrome, universal calcinosis, Reiter's disease and ulcers of sickle-cell anemia. One must always bear in mind the well-defined contraindications to corticosteroid therapy and the hazards of its use, particularly if therapy is to be prolonged. Results from topical hydrocortisone therapy are particularly pleasing in chronic eczematous otitis externa and especially when it is combined with an antibiotic drug. Results are excellent also in nuchal eczema, dermatitis of the eyelids and in pruritus ani. More often than not, hydrocortisone ointment and lotions benefit more than do other standard remedies such diseases as atopic eczema, contact dermatitis, lichen simplex-chronicus and eczematized phases of conditions such as psoriasis and superficial mycotic infections. Preparations containing a combination of hydrocortisone and an antibiotic are more useful than hydrocortisone alone. When used with discrimination, with full attention to the selection of cases and proper concentration in the correct vehicle, hydrocortisone preparations in combination with antibiotics are excellent antieczematous agents.

Topics: Adrenal Cortex; Adrenal Cortex Hormones; Anti-Bacterial Agents; Behcet Syndrome; Dermatitis; Dermatitis, Atopic; Dermatologic Agents; Dermatology; Drug Eruptions; Eczema; Glucocorticoids; Humans; Hydrocortisone; Neurodermatitis; Pruritus Ani; Psoriasis; Skin Diseases