hydrocortisone-21-butyrate has been researched along with Psoriasis* in 1 studies
*Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epider [MeSH]
1 other study(ies) available for hydrocortisone-21-butyrate and Psoriasis
| Article | Year |
|---|---|
Hydrocortisone 17-butyrate degradation in the presence of micro-organisms.
This study compared the degradation of hydrocortisone 17-butyrate (H17B) in the presence of six different bacteria, commonly found on psoriatic skin.. H17B and its degradation products (hydrocortisone and hydrocortisone 21-butyrate (H21B)) were assayed by HPLC.. In the absence of micro-organisms, we observed 16.6 +/- 7.1% degradation. In the presence of micro-organisms and otherwise similar conditions, we noted that H17B degradation was not modified by cocci (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae). Three bacilli increased degradation, Escherichia coli 59.1 +/- 19.4%, Klebsiella oxytoca 62.1 +/- 6.7% and Pseudomonas aeruginosa 56.0 +/- 17.9%.. The degradation of H17B into hydrortisone and H21B may produce a loss of therapeutic activity. Topics: Administration, Topical; Anti-Inflammatory Agents; Bacteria; Biotransformation; Dermatologic Agents; Hydrocortisone; Psoriasis; Skin | 1997 |